The principles and embodiments of the present disclosure relate to a composition for improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function. The composition includes terlipressin acetate having a formula of C52H74N16O15S2·(C2H4O2)n, where n is 2.8.
Provided herein are methods of administering a repository corticotropin pharmaceutical composition in a pre-filled manual apparatus for an adult patient ≥18 years old or a pediatric patient ≥2 years of age by an adult of at least 18 years of age to deliver a one-time use dose only. The manual injector apparatus is capable of being stored at room temperature for up to 24 hours prior to administration and the repository corticotropin pharmaceutical composition is a naturally sourced complex mixture comprising N-25 deamidated porcine ACTH (1-39).
A removable gas sensor module is provided for a therapeutic gas delivery device. The gas sensor module includes a sample chamber which receives a sample gas from the therapeutic gas delivery device. A gas detection unit includes a plurality of sensors operable to measure at least one property of the sample gas. The sensors include two or more of a gas detection sensor, a humidity sensor, a temperature sensor, or a combination thereof. The gas sensor module is self-contained within the therapeutic gas delivery device and swappable with another gas sensor module.
The present disclosure provides methods to improve the viability of an organ, or organs, by continuously administering a composition comprising NOx gas directly to the organ(s).
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparation, namely, nitric oxide for inhalation. Apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparation, namely, nitric oxide for inhalation. Apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparation, namely, nitric oxide for inhalation. Apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations, namely, nitric oxide for inhalation for treating pulmonary hypertension and conditions associated with pulmonary hypertension Apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations, namely, nitric oxide for inhalation for treating pulmonary hypertension and conditions associated with pulmonary hypertension Apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations, namely, nitric oxide for inhalation for treating pulmonary hypertension and conditions associated with pulmonary hypertension Apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
06 - Common metals and ores; objects made of metal
Goods & Services
Support bracket made of metal for securing a medical device to a bed frame, a stretcher, a gurney, transport equipment, or other patient adjacent fixture; metal mounting brackets for general use
Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises a display that provides a visual and/or numeric indication of the calculated dose of nitric oxide. Also described is a method of monitoring nitric oxide delivery, wherein the breathing gas flow rate and therapeutic gas flow rate are measured and used to determine the calculated dose of nitric oxide, which is then displayed. In some embodiments, an alert is provided when the calculated dose rises above or falls below a predetermined level or range.
Disclosed are methods of treatment that permit a reduction of risk of mortality in infants who are candidates for treatment with inhaled nitric oxide, by identifying a subset of such infants who are at an increased risk of mortality upon treatment with inhaled nitric oxide; also disclosed are related systems for use in administering inhaled nitric oxide and methods of distributing a pharmaceutical product.
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
A61K 33/00 - Medicinal preparations containing inorganic active ingredients
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
A61M 16/10 - Preparation of respiratory gases or vapours
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
25.
METHOD OF TREATING PATIENTS WITH HEPATORENAL SYNDROME TYPE 1
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of treating an adult patient with type 1 hepatorenal syndrome (HRS-1) may include administering a dose of terlipressin to the patient if the patient has a baseline model end stage liver disease (MELD) score <35, the patient has a serum creatinine (SCr) <5 mg/dl, the patient has an ACLF Grade <3, or a combination thereof and/or monitoring the patient's oxygenation level (SpO2) before and during treatment with the terlipressin.
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61M 27/00 - Drainage appliances for wounds, or the like
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of treating an adult patient with type 1 hepatorenal syndrome (HRS-1) may include administering a dose of terlipressin to the patient if the patient has a baseline model end stage liver disease (MELD) score <35, the patient has a serum creatinine (SCr)<5 mg/dl, the patient has an ACLF Grade <3, or a combination thereof and/or monitoring the patient's oxygenation level (SpO2) before and during treatment with the terlipressin.
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61M 27/00 - Drainage appliances for wounds, or the like
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of treating an adult patient with type 1 hepatorenal syndrome (HRS-1) may include administering a dose of terlipressin to the patient if the patient has a baseline model end stage liver disease (MELD) score <35, the patient has a serum creatinine (SCr) <5 mg/dl, the patient has an ACLF Grade <3, or a combination thereof and/or monitoring the patient's oxygenation level (SpO2) before and during treatment with the terlipressin.
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61M 27/00 - Drainage appliances for wounds, or the like
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of treating an adult patient with type 1 hepatorenal syndrome (HRS-1) may include administering a dose of terlipressin to the patient if the patient has a baseline model end stage liver disease (MELD) score <35, the patient has a serum creatinine (SCr)<5 mg/dl, the patient has an ACLF Grade <3, or a combination thereof and/or monitoring the patient's oxygenation level (SpO2) before and during treatment with the terlipressin.
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61M 27/00 - Drainage appliances for wounds, or the like
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
Medical and therapeutic apparatus and instruments related to gas applications, namely, nitric oxide machines for use in inhaled nitric oxide therapy, and structural parts and fittings therefor; apparatus and instruments for administering gas to patients for medical and therapeutic purposes
A gas sensor module is provided for a therapeutic gas delivery device. The gas sensor module includes a sample inlet and a sample chamber forming a flow passage fluidly connected with the sample inlet and operable to receive sample gas, where the sample chamber includes a plurality of sensor chambers in communication with one or more corresponding sensors operable to measure at least one property of the sample gas. The flow passage directs a flow of the sample gas through the gas sensor module and includes one or more turns prior to each of the plurality of sensor chambers, each turn having an angle operable to promote mixing of the sample gas and promote diffusion of the sample gas onto each of the plurality of sensors.
A gas sensor module (600) is provided for a therapeutic gas delivery device. The gas sensor module includes a sample inlet (119) and a sample chamber (140) forming a flow passage (144) fluidly connected with the sample inlet and operable to receive sample gas, where the sample chamber includes a plurality of sensor chambers (600, 602, 630) in communication with one or more corresponding sensors (118, 122) operable to measure at least one property of the sample gas. The flow passage directs a flow of the sample gas through the gas sensor module and includes one or more turns (604, 606, 608, 610, 612) prior to each of the plurality of sensor chambers, each turn having an angle operable to promote mixing of the sample gas and promote diffusion of the sample gas onto each of the plurality of sensors.
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
34.
COMPOSITIONS FOR IMPROVING KIDNEY FUNCTION IN PATIENTS WITH HEPATORENAL SYNDROME
The principles and embodiments of the present disclosure relate to a composition for improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function. The composition includes terlipressin acetate having a formula of C52H74N16O15S2·(C2H4O2)n, where n is 2.8.
A method is provided for managing a gas delivery device by a server. The method includes receiving a request to provision a serial number of a PCB from a manufacturing application executing at a manufacturer; providing the serial number and a test firmware to the manufacturer; providing a product firmware to the manufacturing application for installation into the gas delivery device; receiving encrypted data from a gas delivery gateway that is configured to receive performance information from the gas delivery device; decrypting the encrypted data to yield the performance information and storing the performance information in a historical repository; receiving one or more actions that are performed at a servicing application; logging each of the one or more actions in the historical repository; and providing at least one token or data to the servicing application for each of the one or more actions.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G06Q 10/20 - Administration of product repair or maintenance
36.
FILTER ASSEMBLY FOR A THERAPEUTIC GAS DELIVERY DEVICE
Disclosed herein is a sample gas filter assembly (100) for a therapeutic gas delivery device. The filter assembly comprises: - a filter apparatus (106) comprising an inlet (102), an outlet (124), and at least one reservoir (118) and at least one filter membrane (316) between the inlet and the outlet, wherein the filter apparatus is operable to remove water vapor from a sample gas and collect a condensate in the at least one reservoir; - a water-permeable tubular membrane (300) fluidly connected to the outlet of the filter apparatus, and - a ventilated cap (114) connected to the filter apparatus and surrounding the outlet, the ventilated cap comprising a ventilation aperture (116). The sample gas filter assembly is configured for maintaining a condensate pH from an assembly for humidity conditioning and filtering a sample gas in a therapeutic gas delivery device.
Disclosed herein is a sample gas filter for a therapeutic gas delivery device. The sample gas filter can include a housing having a sample gas inlet, which can receive a sample gas from a sample line connected to an inspiratory line of the therapeutic gas delivery device, and a sample gas outlet. The housing can include a first chamber having a first filter membrane and a first reservoir between the sample gas inlet and the first filter membrane. The housing can include a second chamber having a second filter membrane and a second reservoir between the first filter membrane and the sample gas outlet. The first reservoir and the second reservoir can be oriented axially so that the sample gas filter is operable in any axial orientation. The sample gas filter can remove water vapor from the sample gas and collect water in the first and/or second reservoir.
A method is provided for managing a gas delivery device by a server. The method includes receiving a request to provision a serial number of a PCB from a manufacturing application executing at a manufacturer; providing the serial number and a test firmware to the manufacturer; providing a product firmware to the manufacturing application for installation into the gas delivery device; receiving encrypted data from a gas delivery gateway that is configured to receive performance information from the gas delivery device; decrypting the encrypted data to yield the performance information and storing the performance information in a historical repository; receiving one or more actions that are performed at a servicing application; logging each of the one or more actions in the historical repository; and providing at least one token or data to the servicing application for each of the one or more actions.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
39.
FILTER ASSEMBLY FOR A THERAPEUTIC GAS DELIVERY DEVICE
Disclosed herein is a sample gas filter assembly for a therapeutic gas delivery device. The sample gas filter assembly can have a filter apparatus, a water-permeable tubular membrane, and a ventilated cap. The sample gas filter assembly may be configured for maintaining a condensate pH from an assembly for humidity conditioning and filtering a sample gas in a therapeutic gas delivery device.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
Disclosed herein is a sample gas filter for a therapeutic gas delivery device. The sample gas filter can include a housing having a sample gas inlet, which can receive a sample gas from a sample line connected to an inspiratory line of the therapeutic gas delivery device, and a sample gas outlet. The housing can include a first chamber having a first filter membrane and a first reservoir between the sample gas inlet and the first filter membrane. The housing can include a second chamber having a second filter membrane and a second reservoir between the first filter membrane and the sample gas outlet. The first reservoir and the second reservoir can be oriented axially so that the sample gas filter is operable in any axial orientation. The sample gas filter can remove water vapor from the sample gas and collect water in the first and/or second reservoir.
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of treating an adult patient with type 1 hepatorenal syndrome (HRS-1) may include administering a dose of terlipressin to the patient if the patient has a baseline model end stage liver disease (MELD) score<35, the patient has a serum creatinine (SCr)<5 mg/dl, the patient has an ACLF Grade<3, or a combination thereof and/or monitoring the patient's oxygenation level (SpO2) before and during treatment with the terlipressin.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
42.
ADIPONECTIN ALONE OR IN COMBINATION WITH EXTRACORPOREAL PHOTOPHERESIS (ECP) FOR IMMUNE RELATED ADVERSE EVENTS OF IMMUNE CHECKPOINT INHIBITORS
The disclosure relates to a substance adiponectin and/or adiponectin receptor agonist (ARA) for use in the treatment of immune checkpoint blockade (ICB)-induced immune related adverse events (irAEs) in a subject, wherein the subject is preferably receiving checkpoint blockade therapy as a cancer therapy. As well as to a combination medication comprising adiponectin and/or adiponectin receptor agonist (ARA) and a photosensitizing agent for combined use in the treatment of immune checkpoint blockade (ICB)-induced immune related adverse events (irAEs) in a subject, wherein the treatment further comprises the extracorporeal irradiation of a blood sample of the subject with ultraviolet A (UVA), preferably extracorporeal photopheresis (ECP) therapy.
The principles and embodiments of the present disclosure relate to a composition for improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function. The composition includes terlipressin acetate having a formula of C52H74N16O15S2·(C2H4O2)n, where n is 2.8.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations, namely, nitric oxide for inhalation for treating pulmonary hypertension and conditions associated with pulmonary hypertension; Pharmaceutical preparations, namely, inhaled pharmaceutical preparations for treating pulmonary hypertension and conditions associated with pulmonary hypertension. Apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations, namely, nitric oxide for inhalation for treating pulmonary hypertension and conditions associated with pulmonary hypertension; Pharmaceutical preparations, namely, inhaled pharmaceutical preparations for treating pulmonary hypertension and conditions associated with pulmonary hypertension. Apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients
Provided herein is a pre-filled manual apparatus and methods of use thereof. The pre-filled manual apparatus includes a repository corticotropin pharmaceutical composition for an adult patient ≥18 years old in need thereof to deliver a one-time use dose only. The manual injector apparatus is capable of being stored at room temperature for up to 24 hours prior to administration and the repository corticotropin pharmaceutical composition is a naturally sourced complex mixture comprising N-25 deamidated porcine ACTH (1-39).
A trap bowl is provided to accumulate liquid droplets from a filter, as a liquid content. The trap bowl includes a transparent vertical prism. The transparent vertical prism includes a face that forms a vertical transparent surface facing against a content of the section. The face can provide a first angle of total reflection when content of the section is a type of gas, and a second angle of total reflection when the content of the section is the liquid content. A light source may emit a light beam incident on the face at an angle of incidence. The angle of incidence results in reflection of the light beam, striking the light receiver, when the face has the first angle of total reflection, and results in refraction of the light beam, missing the light receiver, when the face has the second angle of total reflection.
B01D 46/62 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition connected in series
A61M 16/10 - Preparation of respiratory gases or vapours
B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
50.
SYSTEMS AND METHODS FOR DELIVERY OF THERAPEUTIC GAS
A therapeutic gas delivery system with at least one gas supply subsystem is disclosed. The at least one gas supply subsystem may include a gas source coupling configured to receive a therapeutic gas source and form a fluid flow connection with the therapeutic gas source, a therapeutic gas delivery system controller, and one or more display(s) configured to be in communication over a communication path with the therapeutic gas delivery system controller. The display may be configured to display a graphical, illustrative, or numerical indicator of one or more flow or system parameters.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
A61M 16/20 - Valves specially adapted to medical respiratory devices
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
A61M 16/10 - Preparation of respiratory gases or vapours
51.
SYSTEMS AND METHODS FOR INTELLIGENT GAS SOURCE MANAGEMENT
A therapeutic gas source and cart and methods thereof for use with a therapeutic gas delivery system is disclosed. The therapeutic gas source may include a cylinder operable to contain a therapeutic gas that includes a body and a gas source valve body. In some examples, the gas source valve body has a valve and a coupling member.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
A61M 16/20 - Valves specially adapted to medical respiratory devices
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
A61M 16/10 - Preparation of respiratory gases or vapours
52.
SYSTEMS AND METHOD FOR DELIVERY OF THERAPEUTIC GAS TO PATIENTS, IN NEED THEREOF, RECEIVING BREATHING GAS FROM A VENTILATOR THAT VARIES AT LEAST PRESSURE AND/OR FLOW USING ENHANCED THERAPEUTIC GAS (NO) FLOW MEASUREMENT
The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a high frequency ventilator using at least enhanced therapeutic gas (e.g., nitric oxide, NO, etc.) flow measurement. At least some of these enhanced therapeutic gas flow measurements can be used to address some surprising phenomenon that may, at times, occur when wild stream blending therapeutic gas into breathing gas a patient receives from a breathing circuit affiliated with a high frequency ventilator. Utilizing at least some of these enhanced therapeutic gas flow measurements the dose of therapeutic gas wild stream blended into breathing gas that the patient receives can at least be more accurate and/or under delivery of therapeutic gas into the breathing gas can be avoided and/or reduced.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations, namely, nitric oxide for inhalation for treating pulmonary hypertension and conditions associated with pulmonary hypertension; Pharmaceutical preparations, namely, inhaled pharmaceutical preparations for treating pulmonary hypertension and conditions associated with pulmonary hypertension Medical apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function may include determining the patient's acute-on-chronic liver failure (ACLF) grade and baseline serum creatinine level; obtaining a baseline oxygenation saturation (SpO2) of the patient; administering a dose of terlipressin acetate to the patient by intravenous (IV) injection; and monitoring the patient's oxygenation saturation with pulse oximetry.
A trap bowl is provided to accumulate liquid droplets from a filter, as a liquid content. The trap bowl includes a transparent vertical prism. The transparent vertical prism includes a face that forms a vertical transparent surface facing against a content of the section. The face can provide a first angle of total reflection when content of the section is a type of gas, and a second angle of total reflection when the content of the section is the liquid content. A light source may emit a light beam incident on the face at an angle of incidence. The angle of incidence results in reflection of the light beam, striking the light receiver, when the face has the first angle of total reflection, and results in refraction of the light beam, missing the light receiver, when the face has the second angle of total reflection.
B01D 46/62 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition connected in series
A61M 16/10 - Preparation of respiratory gases or vapours
B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
57.
2-to-NO reactor cartridge used to deliver no for inhalation therapy to a patient
A61M 16/20 - Valves specially adapted to medical respiratory devices
B01J 8/02 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds
G01F 1/34 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure
58.
METHODS AND COMPOSITIONS FOR IMPROVING KIDNEY FUNCTION IN PATIENTS WITH HEPATORENAL SYNDROME
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function may include determining the patient's acute-on-chronic liver failure (ACLF) grade and baseline serum creatinine level; obtaining a baseline oxygenation saturation (SpO2) of the patient; administering a dose of terlipressin acetate to the patient by intravenous (IV) injection; and monitoring the patient's oxygenation saturation with pulse oximetry.
01 - Chemical and biological materials for industrial, scientific and agricultural use
10 - Medical apparatus and instruments
11 - Environmental control apparatus
Goods & Services
Calibration gases for industrial use Medical apparatus for the administration of gases to human beings for medical and therapeutic purposes; Medical apparatus, namely, precalibrated modules consisting of gases for administering a fixed flow rate of gases for therapeutic and medical use Regulating and safety accessories, namely, gas regulators for the monitoring of gases for industrial uses
60.
Systems and methods for delivery of therapeutic gas
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations, namely, nitric oxide for inhalation for treating pulmonary hypertension and conditions associated with pulmonary hypertension; Pharmaceutical preparations, namely, inhaled pharmaceutical preparations for treating pulmonary hypertension and conditions associated with pulmonary hypertension Medical apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients
62.
METHODS AND COMPOSITIONS FOR IMPROVING KIDNEY FUNCTION IN PATIENTS WITH HEPATORENAL SYNDROME
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function may include determining the patient’s acute-on-chronic liver failure (ACLF) grade and baseline serum creatinine level; obtaining a baseline oxygenation saturation (SpO2) of the patient; administering a dose of terlipressin acetate to the patient by intravenous (IV) injection; and monitoring the patient’s oxygenation saturation with pulse oximetry.
Methods for identifying premature infants at risk for developing bronchopulmonary dysplasia and/or most likely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia (BPD). Methods for treating premature infants identified as at risk and/or likely to benefit are provided. also provided are methods for identifying premature infants that are not at risk for developing bronchopulmonary dysplasia and/or unlikely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia, and methods for avoiding risks of toxicity and undesirable side effects associated with inhaled nitric oxide therapy comprising administering only non-iNO treatment modalities to these infants.
A61K 33/00 - Medicinal preparations containing inorganic active ingredients
A61K 9/00 - Medicinal preparations characterised by special physical form
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH
64.
METHOD OF TREATING PATIENTS WITH HEPATORENAL SYNDROME TYPE 1
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
65.
Administration and monitoring of nitric oxide in ex vivo fluids
Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations, namely, nitric oxide for inhalation for treating pulmonary hypertension and conditions associated with pulmonary hypertension
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for use in extracorporeal photopheresis, extracorporeal photo immune therapy, extracorporeal photo chemotherapy and cellular therapies.
68.
COMPENSATING FOR DISRUPTIONS IN BREATHING GAS FLOW MEASUREMENT
The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, using techniques to compensate for disruptions in breathing gas flow measurement, such as when breathing gas flow measurement is unavailable or unreliable. Such techniques include using historical breathing gas flow rate data, such as moving average flow rates, moving median flow rates and/or flow waveforms. At least some of these techniques can be used to ensure that interruption in therapeutic gas delivery is minimized or eliminated.
A gas delivery system is provided. The gas delivery system includes a pump operable to receive blood from a patient. A gas transfer unit is in fluid communication with the pump and operable to receive the blood from the pump and deliver a therapeutic amount of xenon gas to the blood. A patient connector withdraws and/or infuses the blood into the patient.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
71.
Apparatus and method for filtering liquid particles from inspiratory gas flow of a patient breathing circuit affiliated with a ventilator and/or nitric oxide delivery system
The present disclosure relates to a filter apparatus for filtering liquid from a gas, the apparatus having a first housing having a gas inlet and a gas outlet; a first filter media disposed in the first housing; a second filter media disposed in the housing; and a second housing forming a first collection basin disposed in the flow path between the first filter media and the second filter media, so that a path is defined for the gas flowing from the inlet, through the first filter media, past the collection basin, through the second filter media, and to the outlet. The present disclosure also relates to a method of passing a gas through a coalescing filter media and through a hydrophobic filter media.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
A61M 16/10 - Preparation of respiratory gases or vapours
B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
B01D 46/10 - Particle separators, e.g. dust precipitators, using filter plates, sheets or pads having plane surfaces
B01D 46/42 - Auxiliary equipment or operation thereof
B01D 46/62 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition connected in series
72.
METHOD OF TREATING PATIENTS WITH HEPATORENAL SYNDROME TYPE 1
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A patient identified as suffering from HRS-1 is tested to determine if the patient meets at least two out of three criteria, wherein the three criteria include a WBC<4 or >12 cells/4; HR>90 bpm; and any one of HCO3<21 mmol/L or PaCO2<32 mmHg or >20 breaths per minute. If the patient meets at least two of the criteria, he or she is administered terlipressin in an amount effective to produce a reduction in serum creatinine of at least 1.0 mg/dL.
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
A removable gas sensor module is provided for a therapeutic gas delivery device. The gas sensor module includes a sample chamber which receives a sample gas from the therapeutic gas delivery device. A gas detection unit includes a plurality of sensors operable to measure at least one property of the sample gas. The sensors include two or more of a gas detection sensor, a humidity sensor, a temperature sensor, or a combination thereof. The gas sensor module is self-contained within the therapeutic gas delivery device and swappable with another gas sensor module.
Described are systems and methods for administration of nitric oxide (NO) with use of left ventricular assists devices (LVADs), as well as systems and methods for monitoring the NO delivery devices and/or the LVAD.
A61M 60/148 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
A61M 60/538 - Regulation using real-time blood pump operational parameter data, e.g. motor current
A61M 60/515 - Regulation using real-time patient data
A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
A61B 5/08 - Measuring devices for evaluating the respiratory organs
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of treating an adult patient with type 1 hepatorenal syndrome (HRS-1) may include administering a dose of terlipressin to the patient if the patient has a baseline model end stage liver disease (MELD) score <35, the patient has a serum creatinine (SCr) <5 mg/dl, the patient has an ACLF Grade <3, or a combination thereof and/or monitoring the patient's oxygenation level (SpO2) before and during treatment with the terlipressin.
Apparatus and instruments for use in connection with the administration of gases to patients for medical and therapeutic purposes, namely, medical and therapeutic gas delivery systems comprised primarily of gas cylinders, valves, regulators, flow meters, delivery hoses and apparatus and instruments for setting, measuring and regulating the mixture of medical and therapeutic gases delivered to patients
80.
Systems and method for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a ventilator that varies at least pressure and/or flow using enhanced therapeutic gas (NO) flow measurement
Provided herein are systems and methods for delivery of therapeutic gas to patients, in need thereof, by receiving breathing gas from a high frequency ventilator using at least enhanced therapeutic gas (e.g., nitric oxide, NO, etc.) flow measurement. At least some of these enhanced therapeutic gas flow measurements can be used to address some surprising phenomenon that may, at times, occur when wild stream blending therapeutic gas into breathing gas a patient receives from a breathing circuit affiliated with a high frequency ventilator. Utilizing at least some of these enhanced therapeutic gas flow measurements the dose of therapeutic gas wild stream blended into breathing gas that the patient receives can at least be more accurate and/or under delivery of therapeutic gas into the breathing gas can be avoided and/or reduced.
A61M 16/20 - Valves specially adapted to medical respiratory devices
81.
Apparatus and method for filtering liquid particles from inspiratory gas flow of a patient breathing circuit affiliated with a ventilator and/or nitric oxide delivery system
The present disclosure relates to a filter apparatus for filtering liquid from a gas, the apparatus having a first housing having a gas inlet and a gas outlet; a first filter media disposed in the first housing; a second filter media disposed in the housing; and a second housing forming a first collection basin disposed in the flow path between the first filter media and the second filter media, so that a path is defined for the gas flowing from the inlet, through the first filter media, past the collection basin, through the second filter media, and to the outlet. The present disclosure also relates to a method of passing a gas through a coalescing filter media and through a hydrophobic filter media.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
A61M 16/20 - Valves specially adapted to medical respiratory devices
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
A61M 16/10 - Preparation of respiratory gases or vapours
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
A61M 16/20 - Valves specially adapted to medical respiratory devices
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
A61M 16/10 - Preparation of respiratory gases or vapours
Methods for identifying premature infants at risk for developing bronchopulmonary dysplasia and/or most likely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia (BPD). Methods for treating premature infants identified as at risk and/or likely to benefit are provided. also provided are methods for identifying premature infants that are not at risk for developing bronchopulmonary dysplasia and/or unlikely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia, and methods for avoiding risks of toxicity and undesirable side effects associated with inhaled nitric oxide therapy comprising administering only non-iNO treatment modalities to these infants.
A61K 33/00 - Medicinal preparations containing inorganic active ingredients
G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
A61K 9/00 - Medicinal preparations characterised by special physical form
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
86.
Systems and methods for delivery of therapeutic gas
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
A61M 16/20 - Valves specially adapted to medical respiratory devices
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
A61M 16/10 - Preparation of respiratory gases or vapours
The present invention provides clinical decision support that can be used with non-portable and portable systems when delivering and/or monitoring delivery of a therapeutic gas comprising nitric oxide to a patient. Further, clinical decision support can be used with non-portable and portable systems during delivery and/or monitoring of delivery of therapeutic gas when nebulized drugs may and/or may not be being delivered to a patient (e.g., when nebulizers are delivered upstream in the inspiratory limb of the breathing circuit, into a breathing gas delivery system, etc.).
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
A61M 16/10 - Preparation of respiratory gases or vapours
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
A trap bowl is provided to accumulate liquid droplets from a filter, as a liquid content. The trap bowl includes a transparent vertical prism. The transparent vertical prism includes a face that forms a vertical transparent surface facing against a content of the section. The face can provide a first angle of total reflection when content of the section is a type of gas, and a second angle of total reflection when the content of the section is the liquid content. A light source may emit a light beam incident on the face at an angle of incidence. The angle of incidence results in reflection of the light beam, striking the light receiver, when the face has the first angle of total reflection, and results in refraction of the light beam, missing the light receiver, when the face has the second angle of total reflection.
B01D 46/62 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition connected in series
A61M 16/10 - Preparation of respiratory gases or vapours
B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
90.
Compensating for disruptions in breathing gas flow measurement
The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, using techniques to compensate for disruptions in breathing gas flow measurement, such as when breathing gas flow measurement is unavailable or unreliable. Such techniques include using historical breathing gas flow rate data, such as moving average flow rates, moving median flow rates and/or flow waveforms. At least some of these techniques can be used to ensure that interruption in therapeutic gas delivery is minimized or eliminated.
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
A61M 16/20 - Valves specially adapted to medical respiratory devices
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
A61M 16/10 - Preparation of respiratory gases or vapours
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations; pharmaceutical preparations for
the treatment of neurological diseases and disorders,
nephrotic diseases, endocrine disorders, rheumatic
disorders, collagen diseases, dermatologic diseases and
disorders, allergic states, ophthalmic diseases, respiratory
diseases, hematologic disorders, neoplastic diseases,
edematous state, gastrointestinal diseases, hepatic diseases
and disorders, biliary diseases and disorders, renal
disorders, cardiovascular and lipid-related diseases and
disorders, inflammatory and autoimmune diseases and
disorders, intravenous analgesics and antipyretics; medical
gases for inhalation; bioengineered living tissues for
surgical implantation; devices incorporating prefilled
syringes containing injectable pharmaceuticals for manual
injection. Medical devices; medical apparatus; medical apparatus and
instruments for use in connection with the administration of
gases to patients for medical and therapeutic purposes and
accessories and parts thereof, namely, medical and
therapeutic gas delivery systems comprised primarily of gas
cylinders, valves, regulators, flow meters, delivery hoses
and apparatus and instruments for setting, measuring and
regulating the mixture of medical and therapeutic gases
delivered to patients; therapeutic medical device and
accessories and parts thereof for extracting blood from the
body, separating blood, treating it extracorporally, and
returning it to the body used for extracorporeal
photopheresis, extracorporeal photo immune therapy,
extracorporeal photo chemotherapy, and cellular therapies. Custom manufacturing services for pharmaceuticals and active
pharmaceutical ingredients. Training services and educational support in the fields of
pharmaceuticals and medical devices. Scientific research services for medical purposes.
94.
Apparatus and method for humidity conditioning sample gas of a patient breathing circuit affiliated with a ventilator and/or nitric oxide delivery system
A therapeutic gas is administered to a patient. A sample gas is drawn from the therapeutic gas supply, and passed through a water-permeable tubular membrane. Concurrently, a section of the water permeable tubular membrane is maintained as a ventilated water permeable tubular membrane, by exposing outer surfaces of the ventilated water permeable tubular membrane to an ambient air flow. The ambient air flow may in some examples be moved over the tubular membrane via forced air such as for example via a fan associated with a housing surrounding the tubular membrane.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations; pharmaceutical preparations for
the treatment of neurological diseases and disorders,
nephrotic diseases, endocrine disorders, rheumatic
disorders, collagen diseases, dermatologic diseases and
disorders, allergic states, ophthalmic diseases, respiratory
diseases, hematologic disorders, neoplastic diseases,
edematous state, gastrointestinal diseases, hepatic diseases
and disorders, biliary diseases and disorders, renal
disorders, cardiovascular and lipid-related diseases and
disorders, inflammatory and autoimmune diseases and
disorders; intravenous analgesics and antipyretics; medical
gases for inhalation; bioengineered tissues for surgical
implantation. Medical devices; medical apparatus; medical apparatus and
instruments for use in connection with the administration of
gases to patients for medical and therapeutic purposes and
accessories and parts thereof, namely, medical and
therapeutic gas delivery systems comprised primarily of gas
cylinders, valves, regulators, flow meters, delivery hoses
and apparatus and instruments for setting, measuring and
regulating the mixture of medical and therapeutic gases
delivered to patients; therapeutic medical device and
accessories and parts thereof for extracting blood from the
body, separating blood, treating it extracorporally, and
returning it to the body used for extracorporeal
photopheresis, extracorporeal photo immune therapy,
extracorporeal photo chemotherapy, and cellular therapies;
devices incorporating prefilled syringes containing
injectable pharmaceuticals for manual injection. Custom manufacturing services for pharmaceuticals and active
pharmaceutical ingredients. Training services and educational support in the fields of
pharmaceuticals and medical devices. Scientific research services for medical purposes.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations; pharmaceutical preparations for
the treatment of neurological diseases and disorders,
nephrotic diseases, endocrine disorders, rheumatic
disorders, collagen diseases, dermatologic diseases and
disorders, allergic states, ophthalmic diseases, respiratory
diseases, hematologic disorders, neoplastic diseases,
edematous state, gastrointestinal diseases, hepatic diseases
and disorders, biliary diseases and disorders, renal
disorders, cardiovascular and lipid-related diseases and
disorders, inflammatory and autoimmune diseases and
disorders; intravenous analgesics and antipyretics; medical
gases for inhalation; bioengineered tissues for surgical
implantation. Medical devices; medical apparatus; medical apparatus and
instruments for use in connection with the administration of
gases to patients for medical and therapeutic purposes and
accessories and parts thereof, namely, medical and
therapeutic gas delivery systems comprised primarily of gas
cylinders, valves, regulators, flow meters, delivery hoses
and apparatus and instruments for setting, measuring and
regulating the mixture of medical and therapeutic gases
delivered to patients; therapeutic medical device and
accessories and parts thereof for extracting blood from the
body, separating blood, treating it extracorporally, and
returning it to the body used for extracorporeal
photopheresis, extracorporeal photo immune therapy,
extracorporeal photo chemotherapy, and cellular therapies;
devices incorporating prefilled syringes containing
injectable pharmaceuticals for manual injection. Custom manufacturing services for pharmaceuticals and active
pharmaceutical ingredients. Training services and educational support in the fields of
pharmaceuticals and medical devices. Scientific research services for medical purposes.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations; pharmaceutical preparations for
the treatment of neurological diseases and disorders,
nephrotic diseases, endocrine disorders, rheumatic
disorders, collagen diseases, dermatologic diseases and
disorders, allergic states, ophthalmic diseases, respiratory
diseases, hematologic disorders, neoplastic diseases,
edematous state, gastrointestinal diseases, hepatic diseases
and disorders, biliary diseases and disorders, renal
disorders, cardiovascular and lipid-related diseases and
disorders, inflammatory and autoimmune diseases and
disorders; intravenous analgesics and antipyretics; medical
gases for inhalation; bioengineered tissues for surgical
implantation. Medical devices; medical apparatus; medical apparatus and
instruments for use in connection with the administration of
gases to patients for medical and therapeutic purposes and
accessories and parts thereof, namely, medical and
therapeutic gas delivery systems comprised primarily of gas
cylinders, valves, regulators, flow meters, delivery hoses
and apparatus and instruments for setting, measuring and
regulating the mixture of medical and therapeutic gases
delivered to patients; therapeutic medical device and
accessories and parts thereof for extracting blood from the
body, separating blood, treating it extracorporally, and
returning it to the body used for extracorporeal
photopheresis, extracorporeal photo immune therapy,
extracorporeal photo chemotherapy, and cellular therapies;
devices incorporating prefilled syringes containing
injectable pharmaceuticals for manual injection. Custom manufacturing services for pharmaceuticals and active
pharmaceutical ingredients. Training services and educational support in the fields of
pharmaceuticals and medical devices. Scientific research services for medical purposes.
98.
Apparatus and method for monitoring nitric oxide delivery
Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises a display that provides a visual and/or numeric indication of the calculated dose of nitric oxide. Also described is a method of monitoring nitric oxide delivery, wherein the breathing gas flow rate and therapeutic gas flow rate are measured and used to determine the calculated dose of nitric oxide, which is then displayed. In some embodiments, an alert is provided when the calculated dose rises above or falls below a predetermined level or range.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations; pharmaceutical preparations for
the treatment of neurological diseases and disorders,
nephrotic diseases, endocrine disorders, rheumatic
disorders, collagen diseases, dermatologic diseases and
disorders, allergic states, ophthalmic diseases, respiratory
diseases, hematologic disorders, neoplastic diseases,
edematous state, gastrointestinal diseases, hepatic diseases
and disorders, biliary diseases and disorders, renal
disorders, cardiovascular and lipid-related diseases and
disorders, inflammatory and autoimmune diseases and
disorders; intravenous analgesics and antipyretics; medical
gases for inhalation; bioengineered tissues for surgical
implantation. Medical devices; medical apparatus; medical apparatus and
instruments for use in connection with the administration of
gases to patients for medical and therapeutic purposes and
accessories and parts thereof, namely, medical and
therapeutic gas delivery systems comprised primarily of gas
cylinders, valves, regulators, flow meters, delivery hoses
and apparatus and instruments for setting, measuring and
regulating the mixture of medical and therapeutic gases
delivered to patients; therapeutic medical device and
accessories and parts thereof for extracting blood from the
body, separating blood, treating it extracorporally, and
returning it to the body used for extracorporeal
photopheresis, extracorporeal photo immune therapy,
extracorporeal photo chemotherapy, and cellular therapies;
device with prefilled syringe containing injectable
pharmaceuticals for manual injection.
100.
Therapeutic gas delivery device with pulsed and continuous flow control
Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve and at least one binary control valve. The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths.
