Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In one embodiment, an apparatus to generate a test result from an assay, when contacted with a sample, includes a non-planar optics module, an imaging device, and a direct, dynamically-controlled lighting assembly. The assembly may include an aperture carrier heat block having a plurality of optical windows and enhancing manipulation of an assay about the assembly.
A leak detection system and assembly. In one embodiment, a refrigeration system includes a non-invasive ultrasonic flowmeter to monitor an ultrasonic signal. The result is a refrigeration system to trigger a leak detection alert.
G01M 3/26 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
F25B 49/02 - Arrangement or mounting of control or safety devices for compression type machines, plants or systems
G01F 1/66 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters
Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In a lateral flow reader to generate a test result from an assay when contacted with a sample and having a camera multiplexer circuit and a host controller. An assembly includes an interface connector; a self-contained optics module having a microcontroller in electrical communication with the interface connector and a host controller. Typically, an optical imaging device being in communication with an interface connector but independent of a microcontroller.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/84 - Systems specially adapted for particular applications
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
4.
Handheld luminometer and front end platform assembly
A handheld luminometer system and assembly are shown and described. In one embodiment, an assembly includes a portable luminometer and a front end platform having a microcontroller circuit to communicate with a host device. Typically, the portable luminometer includes a sample port to accept a test sample holder, a photomultiplier assembly with at least one photomultiplier tube, and a base. The result is a luminometer assembly for use with a single-use test sample holder in communication with a host device.
Sample preparation and detection devices, methods, and assemblies are shown and described. In one embodiment, an assembly for preparing a sample for predicting a bacterial presence includes a compartmentalized container having a sample collector reservoir, a first storage compartment, and a second storage compartment. The result is improved efficient and effective predicting of a bacterial presence.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In one embodiment, an apparatus to generate a test result from an assay, when contacted with a sample, includes a non-planaroptics module, an imaging device, and a direct, dynamically-controlled lighting assembly. The assembly may include an aperture carrier heat block having a plurality of optical windows and enhancing manipulation of an assay about the assembly.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/84 - Systems specially adapted for particular applications
Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In one embodiment, an apparatus to generate a test result from an assay, when contacted with a sample, includes a non-planar optics module, an imaging device, and a direct, dynamically-controlled lighting assembly. The assembly may include an aperture carrier heat block having a plurality of optical windows and enhancing manipulation of an assay about the assembly.
G01N 21/84 - Systems specially adapted for particular applications
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
A method of preparing for analysis of a sample is shown and described. In one embodiment, the method includes soaking at least one sample collector in an apyrase solution, and removing the apyrase solution. The result is preparing the sample collector by removing adenosine triphosphate from the sample collector.
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
A leak detection system and assembly. In one embodiment, a refrigeration system includes a non-invasive ultrasonic flowmeter to monitor an ultrasonic signal. The result is a refrigeration system to trigger a leak detection alert.
G01F 23/02 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by gauge glasses or other apparatus involving a window or transparent tube for directly observing the level to be measured or the level of a liquid column in free communication with the main body of the liquid
G01F 1/86 - Indirect mass flowmeters, e.g. measuring volume flow and density, temperature, or pressure
09 - Scientific and electric apparatus and instruments
Goods & Services
Diagnostic instruments, not for medical purposes, for use in the analysis of milk and other foods and food products, for the detection of antibiotics, toxins, and other contaminating residues, namely, incubators for incubating cultures, data processors, optical sensors, computer chips, light emitting diodes (LEDs), light emitting diode (LED) displays, electronic luminescent display panels, computer memory, micro-processors, micro-computers, optical mirrors
Reader and plate methods, operations, and systems for observing a biological sample are shown and described. In one embodiment, a device for observing biological growth, when present, on a growth plate, includes an imaging device and a variable positioning nest. The nest may include a first sunken frame to receive a first growth plate, and an offset second sunken frame to receive a distinct second growth plate in an operating position offset about the first operating position.
Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In one embodiment, an apparatus to generate a test result from an assay when contacted with a sample includes a non-planar optics module to align the assay in an offset testing position. A modular interface assembly may support a motherboard and at least one non-planar optics module.
G01N 21/84 - Systems specially adapted for particular applications
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
A method for extracting a mycotoxin, when present, from a sample. Compositions and methods include the use of high ionic strength compositions including compositions that include many amine and/or carboxyl groups such as protein based, amino acid based and polyethylene glycol based composition.
Sample preparation and detection devices, methods, and assemblies are shown and described. In one embodiment, an assembly for preparing a sample for predicting a bacterial presence includes a compartmentalized container having a sample collector reservoir, a first storage compartment, and a second storage compartment. The result is improved efficient and effective predicting of a bacterial presence.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
A method of preparing for analysis of a sample is shown and described. In one embodiment, the method includes soaking at least one sample collector in an apyrase solution, and removing the apyrase solution. The result is preparing the sample collector by removing adenosine triphosphate from the sample collector.
A61B 50/37 - Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments for collecting or disposing of used articles for absorbent articles, e.g. bandages, garments, swabs or towels
A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
Sample collection and analysis devices, methods, and assemblies are shown and described. In one embodiment, an assembly includes a sample collection device and a removable vial having a penetrable barrier seal to prevent access to the vial until at least one penetrable activation. The result is improved efficient and effective sample collection and analysis.
Sample collection and analysis devices, methods, and assemblies are shown and described. In one embodiment, an assembly includes a sample collection device and a removable vial having a penetrable barrier seal to prevent access to the vial until at least one penetrable activation. The result is improved efficient and effective sample collection and analysis.
Test strip devices, assemblies, systems, and methods for the analysis of a sample are shown and described. In one embodiment, a test strip includes a nitrocellulose membrane, a filtration conjugate pad with a fibrous labeled receptor bottom side, and an overlay tape enclosing the nitrocellulose membrane and a portion of the filtration conjugate pad. An assembly may include a delivery device for delivering sample to the test strip.
Embodiments described herein include detecting an analyte in a low pH sample. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone.
Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/84 - Systems specially adapted for particular applications
Reader and plate methods, operations, and systems for observing a biological sample are shown and described. In one embodiment, a device for observing biological growth, when present, on a growth plate, includes an imaging device and a variable positioning nest. The nest may include a first sunken frame to receive a first growth plate, and an offset second sunken frame to receive a distinct second growth plate in an operating position offset about the first operating position.
Reader observation and monitoring of the imaging of biological development is shown and described. In one embodiment, a method for monitoring biological growth includes identifying an alert from comparing a background value identified on a plate to a non-background value identified on a plate. In particular examples, a pre-filter, threshold, and histogram analysis identifies an alert count.
Peel plates and plate assemblies are shown and described. In one embodiment, a peel plate assembly includes a semi-rigid plate, a removable cover seal, and an adhesive to provide a moisture vapor barrier. In particular embodiments, the moisture vapor barrier provides less than about one pound peel adhesion and a stiffness for reapplication without wrinkling. The result is a peel plate, assembly, and method for the enumerating a microorganism, when present, in a sample.
Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In one embodiment, an apparatus to generate a test result from an assay when contacted with a sample includes a non-planar optics module to align the assay in an offset testing position. A modular interface assembly may support a motherboard and at least one nonplanar optics module.
G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/84 - Systems specially adapted for particular applications
Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In one embodiment, an apparatus to generate a test result from an assay when contacted with a sample includes a non-planar optics module to align the assay in an offset testing position. A modular interface assembly may support a motherboard and at least one nonplanar optics module.
G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/84 - Systems specially adapted for particular applications
In-line testing and product delivery assemblies, methods, operations, and systems are shown and described. In one embodiment, an in-line testing and product delivery system includes a supply of product having at least one outlet with a valve closure and a downstream delivery line, a recirculation closed loop in fluid communication with the outlet and supply, and a reader to generate a rapid test result from a single use assay for detection of a presence or an absence of an analyte in the supply. The result provides monitoring of a detection of the analyte to block release of product supply into the delivery line.
A single unit assay device, method, and assembly is shown and described. In one embodiment, a self-contained assembly and method analyze a sample for a presence of one or more analytes, residues, and may include comparing visual intensity of a detectable signal of a test area to a visual intensity of a control area. The result is an improved field test for efficient and effective qualitative analysis.
System, apparatus, and assemblies for the detection of at least one analyte in a sample are shown and described. The system may be an onboard vehicle system to generate an antibiotic test result from an antibiotic analyte assay.
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 21/84 - Systems specially adapted for particular applications
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
Reader and plate methods, operations, and systems for observing a biological sample are shown and described. In one embodiment, a reader device includes selecting a plate type between at least two plate type selections on a user interface. One embodiment includes aligning a peel plate within a tray holder nest to define a semi-fixed processing position. One embodiment includes transporting a peel plate from a loading position into a focal alignment with an imaging device for monitoring biological growth, when present.
Reader observation and monitoring of the imaging of biological development is shown and described. In one embodiment, a method for monitoring biological growth includes identifying an alert from comparing a background value identified on a plate to a non-background value identified on a plate. In particular examples, a pre-filter, threshold, and histogram analysis identifies an alert count.
Culture medium devices and systems are shown and described. In one embodiment a growth plate includes an upper surface, a recessed well, a raised platform having an opposing cavity, and raised extensions having an opposing receiving aperture. Typically, the well is recessed below the top surface and the platform is above the upper surface. A growth plate assembly typically includes at least a first growth plate's raised stacking surfaces being temporarily received by a second growth plate's receiving surfaces, thereby temporarily securing growth plates together.
In-line testing and product delivery assemblies, methods, operations, and systems are shown and described. In one embodiment, an in-line testing and product delivery system includes a supply of product having at least one outlet with a valve closure and a downstream delivery line, a recirculation closed loop in fluid communication with the outlet and supply, and a reader to generate a rapid test result from a single use assay for detection of a presence or an absence of an analyte in the supply. The result provides monitoring of a detection of the analyte to block release of product supply into the delivery line.
Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 21/84 - Systems specially adapted for particular applications
A single unit assay device, method, and assembly is shown and described. In one embodiment, a method for analyzing a sample for a presence of one or more analytes, residues, and the like includes comparing visual intensity of a detectable signal of a test area to a visual intensity of a control area. The result is an improved field test for efficient and effective qualitative analysis.
Embodiments described herein include detecting an analyte in a low pH sample. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone.
Culture medium devices and systems are shown and described. In one embodiment, a peel plate includes a recessed well, a raised platform, and a removable adhesive cover. In certain examples, the recessed well receives a sample on a dried media culture disc. The removable cover may have a first end secured adjacent to the raised platform and a second removable end removably enclosing the recessed well. The result is a peel plate, assembly, and methods for the enumerating a microorganism, when present, in a sample.
Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/84 - Systems specially adapted for particular applications
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 21/84 - Systems specially adapted for particular applications
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
39.
PLATE READER CALIBRATION, SECURE OPERATION, AND IMPROVED PEEL PLATE
Reader and plate methods, operations, and systems for imaging/counting biological development on plates are shown and described. One embodiment Includes calibrating a plate reader. Calibration may be triggered by detecting a quality control event or the like. The calibration process may include receiving a low and/or high calibrator, counting objects on. The calibrator(s)s and comparing objects on the calibrator(s) to a predetermined limit. The result is an improved plate reader for observing biological growth, when present, on a growth plate.
Assessing test results development during assay analysis is shown and described. In one embodiment, an apparatus generates an assessment of diagnostic test development from an assay. The apparatus may include an optical detector aligned in an optical path with the assay. Further, the optical detector may perform continuous image detection of the assay to generate an assessment testing development. In some examples, the assessment is a graphical display of diagnostic development. In yet other embodiments, a method of assessing diagnostic test development may include signaling the optical detector to perform continuing image detection of the assay and generating an assessment of said diagnostic test development. The assessment may include graphing a reflectance detected on the assay on a display board.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemically treated non-medical diagnostic test strips comprising biological and chemical reagents for detecting microorganisms or chemicals in various environments
Hygiene control stations and methods are shown and described. In one embodiment, the control station includes picking compartments with corresponding automated inventory control. Further, the control stations may include user instructions and best hygiene practices. In particular examples, the control stations include sensors and alarms to ensure proper usage. The result is control systems and methods to improve hygiene care, infection control, inventory management, and the like.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemically treated non-medical diagnostic test strips comprising biological and chemical reagents for detecting microorganisms or chemicals in various environments
An improved luminometer, chamber insert, and deactivator is shown and described. In one embodiment, the device comprises a luminometer for use with a test sample holder and is configured to determine the emitted light from the test sample holder. Typically, the luminometer includes a housing having a sample port, a photomultiplier assembly, and a chamber having a mirrored inner side face. In certain examples, an improved chamber for a luminometer comprises an insert portion, a photomultiplier portion, and a deactivator.
Embodiments described herein include methods and assays for detecting beta-lactam analytes and mycotoxin analytes in a sample. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.
G01N 33/558 - ImmunoassayBiospecific binding assayMaterials therefor using diffusion or migration of antigen or antibody
G01N 33/544 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
Culture medium devices and systems are shown and described. In one embodiment, a peel plate includes a recessed well, a raised platform, and a removable adhesive cover. In certain examples, the recessed well receives a sample on a dried media culture disc. The removable cover may have a first end secured adjacent to the raised platform and a second removable end removably enclosing the recessed well. The result is a peel plate, assembly, and methods for the enumerating a microorganism, when present, in a sample.
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
B01L 99/00 - Subject matter not provided for in other groups of this subclass
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
Culture medium devices and systems are shown and described. In one embodiment, the device comprises a culture medium adapted for test fluid inoculation without the concerns associated with a spreading step. In particular examples, a printed grid on the outer surface of a culture device is visible on the inner surface for colony counting after a test has been developed. The result is a device that allows for detection, identification, and transportation of various microorganisms without preparation or spreading steps, and more particularly to a culture medium in which a test fluid inoculated thereto diffuses rapidly.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
A method and test strip for detecting one or more analytes in a test solution. The method and test strip include a detectable component, such as a gold particle, that is linked to a binder, such as an antibody, through a linkage. The linkage can include an antibody binding protein and an antispecies antibody.
G01N 33/537 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
Detecting a definitive presence or absence of an analyte from a borderline test is shown and described. In one embodiment, a method of generating a definitive test result includes continuously incubating the assay concurrently with continuously reading a diagnostic test on the assay. In particular examples, reading the diagnostic test on the assay includes performing a one minute diagnostic reading. Typically, when a borderline test result is detected, further development of the assay is performed. In most examples, detecting a definitive presence or absence test result deactivates the testing sequence.
A method and composition for extracting an analyte from a test sample such as grain, so as to determine whether the test sample is contaminated with a toxin. The method is particularly useful for detecting the presence in a batch of grain of a mycotoxin, such as for example aflatoxin, ochratoxin, T2, zearalanone, vomitoxin (deoxynivalenol a/k/a DON), patulin and fumonisin. Extraction is performed with use of a composition that includes a proteinaceous material, such as albumin, as an extraction agent.
Analyte detection systems and devices are provided. In one embodiment, a sensor initially reviews an assay, for instance a test strip, to designate a particular testing sequence. The sensor may calibrate the unit and then identify the particular testing sequence by identifying a color indicator on the test strip. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.
Assessing test results development during assay analysis is shown and described. In one embodiment, an apparatus generates an assessment of diagnostic test development from an assay. The apparatus may include an optical detector aligned in an optical path with the assay. Further, the optical detector may perform continuous image detection of the assay to generate an assessment testing development. In some examples, the assessment is a graphical display of diagnostic development. In yet other embodiments, a method of assessing diagnostic test development may include signaling the optical detector to perform continuing image detection of the assay and generating an assessment of said diagnostic test development. The assessment may include graphing a reflectance detected on the assay on a display board.
Label complexes, lateral flow apparatus and methods of detecting a high molecular weight substance are shown and described. In one embodiment, the label complex includes an antispecies antibody and another antibody having sensitivity to both the antispecies antibody and to a control line capture agent, an antibody binding protein and a detectable component. Typically, the antibody binding protein may bind to a receptor for the analyte or to the anti-species antibody. In yet other embodiments, a lateral flow test strip includes the label complex and a solid support that traverses lateral flow of a liquid sample and provides a detectable signal.
Detecting a definitive presence or absence of an analyte from a borderline test is shown and described. In one embodiment, a method of generating a definitive test result includes continuously incubating the assay concuiTently with continuously reading a diagnostic test on the assay. In particular examples, reading the diagnostic test on the assay includes performing a one minute diagnostic reading. Typically, when a borderline test result is detected, further development of the assay is performed. In most examples, detecting a definitive presence or absence test result deactivates the testing sequence.
Culture medium devices and systems are shown and described. In one embodiment, the device comprises a culture medium adapted for test fluid inoculation without the concerns associated with a spreading step. In particular examples, a printed grid on the outer surface of a culture device is visible on the inner surface for colony counting after a test has been developed. The result is a device that allows for detection, identification, and transportation of various microorganisms without preparation or spreading steps, and more particularly to a culture medium in which a test fluid inoculated thereto diffuses rapidly.
Lateral flow assay analysis is shown and described. In one embodiment, the lateral flow assay comprises a surface having a reflectance profile that is adapted to enable monitoring of the assay continuously until the detection of an analyte. In other embodiments, a lateral flow assay system includes an incubator and a reader, wherein the incubator incubates the assay concurrently as the reader generates a test result. Further, an assay measurement apparatus may include an optical detector to perform continuous image detection of the assay to generate a diagnostic test result.
A method and composition for extracting an analyte from a test sample such as grain, so as to determine whether the test sample is contaminated with a toxin. The method is particularly useful for detecting the presence in a batch of grain of a mycotoxin, such as for example aflatoxin, ochratoxin, T2, zearalanone, vomitoxin (deoxynivalenol a/k/a DON), patulin and fumonisin. Extraction is performed with use of a composition that includes a proteinaceous material, such as albumin, as an extraction agent.
Disclosed herein is a method and device for testing an agricultural product for the presence of an unwanted residue including a reader-incubator combination that can utilize onboard motor vehicle systems, such as an onboard microprocessor and onboard power supply.
A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.
Label complexes, lateral flow apparatus and methods of detecting a high molecular weight substance are shown and described. In one embodiment, the label complex includes an antispecies antibody and another antibody having sensitivity to both the antispecies antibody and to a control line capture agent, an antibody binding protein and a detectable component. Typically, the antibody binding protein may bind to a receptor for the analyte or to the anti-species antibody. In yet other embodiments, a lateral flow test strip includes the label complex and a solid support that traverses lateral flow of a liquid sample and provides a detectable signal.
This application involves detecting luminescence. Various methods and devices are described that reduce interference of ambient light, including UV radiation, on test results. Such methods and devices include using UV blocking material and covering test components prior to use.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
assay diagnostic kits comprising powder reagents and/or test strips for use in detecting toxins, antibiotics and other contaminates in commodities and food products
A method, test strip and method of manufacturing a test strip useful for detecting one or more analytes, such as an antibiotic, in a test sample such as a milk sample. The test strip and method include a labeled specific binder and test capture agent for the specific binder that increases test sensitivity to the analyte for which the specific binder has affinity while decreasing test sensitivity to an analyte for which a multianalyte binder has affinity.
Lateral flow assay analysis is shown and described. In one embodiment, the lateral flow assay comprises a surface having a reflectance profile that is adapted to enable monitoring of the assay continuously until the detection of an analyte. In other embodiments, a lateral flow assay system includes an incubator and a reader, wherein the incubator incubates the assay concurrently as the reader generates a test result. Further, an assay measurement apparatus may include an optical detector to perform continuous image detection of the assay to generate a diagnostic test result.
Disclosed herein is a method and device for testing an agricultural product for the presence of an unwanted residue including a reader-incubator combination that can utilize onboard motor vehicle systems, such as an onboard microprocessor and onboard power supply?
09 - Scientific and electric apparatus and instruments
Goods & Services
Diagnostic instruments for use in the analysis of milk and other foods and food products, for the detection of antibiotics, toxins, and other contaminating residues, namely, incubators for incubating cultures, data processors, optical sensors, computer chips, light emitting diodes (LEDs), light emitting diode (LED) displays, electronic luminescent display panels, computer memory, micro-processors, micro-computers, optical mirrors, computer operating systems, computer software, computer programs, power supplies, signal processors, thermometers, and thermostats and computer printers
A method, test strip and method of manufacturing a test strip useful for detecting one or more analytes, such as an antibiotic, in a test sample such as a milk sample. The test strip and method include a labeled specific binder and test capture agent for the specific binder that increases test sensitivity to the analyte for which the specific binder has affinity while decreasing test sensitivity to an analyte for which a multianalyte binder has affinity.
An assay reader system incorporating a conventional assay reader, for example a lateral flow reader, and an insert aligned with the reader's sensor to detect an assay result. The insert may include a housing which defines a cavity to receive a removable barrier, wherein the removable barrier can be aligned between the sensor and the test strip. The barrier may include an optical window, and may be cleanable and/or disposable to maintain the accuracy of the reader. Test strips are introduced into the reader through a receiving port within the insert's housing. An air inlet on the insert further maintains the reader's accuracy by allowing air to be tunneled over the housing to remove excess dust, debris, or the like.
An aspect of the disclosure is a method and device for the detection of antibiotics in a sample. Embodiments include a microbial culture with growth indicators and sensitivity adjustment reagents. Adjustment reagents include a variety of antibiotic binders that can be added to microbial culture to reduce sensitivity to certain antibiotics. Some embodiments include multiple buffers with a variety of pKa ranges. Some embodiments also include a complete self-contained apparatus for sampling and testing.
Phages can be detected as rapid indicators of the hygienic quality of a sample. Both continuous flow methods and devices, single sample methods and devices, of various volumes, can be used. Single samples may be tested by single or multi-step testing methods. Test kits can be provided in easy-to-use formats. Certain phages, such as coliphage, are useful as indicators of fecal contamination.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
A substantially moisture-tight unit for packaging moisture-sensitive items. The unit includes a container and cap. The container has a closed container bottom, a container top, a sidewall extending upwardly from the container bottom to the container top and a fixed surface at, or near, the container top. The unit also includes a cap. The cap has a lid and a moisture impervious layer attached to an inside portion of the lid. The lid can snap onto the container to hold the moisture impervious layer against a fixed surface forming a moisture barrier.
An assay reader system incorporating a conventional assay reader, for example a lateral flow reader, and an insert aligned with the reader's sensor to detect an assay result. The insert may include a housing which defines a cavity to receive a removable barrier, wherein the removable barrier can be aligned between the sensor and the test strip. The barrier may include an optical window, and may be cleanable and/or disposable to maintain the accuracy of the reader. Test strips are introduced into the reader through a receiving port within the insert's housing. An air inlet on the insert further maintains the reader's accuracy by allowing air to be tunneled over the housing to remove excess dust, debris, or the like.
A method and apparatus for controlled concentration of an analyte containing liquid sample. Embodiments include using microwave energy to heat a sample while reducing pressure in a chamber. The combination of reduced pressure and microwave energy can provide sufficient heat to vaporize a portion of the liquid while maintaining analyte integrity. The method and apparatus can increase speed and sensitivity of analyte detection.
Phage can be detected as rapid indicators of the hygienic quality of a sample. Both continuous flow methods and devices and single sample methods and devices, of various volumes, can be used. Test kits can be provided in easy-to-use formats. Certain phage, such as coliphage, are useful as indicators of fecal contamination.
A test device configured for obtaining a sample from within a tube such as the one or more channels of an endoscope. The device can include an elongate sample probe and light blocking material.
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.
Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.
A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.
A substantially moisture-tight unit for packaging moisture-sensitive items. The unit includes a container and cap. The container has a closed container bottom, a container top, a sidewall extending upwardly from the container bottom to the container top and a fixed surface at, or near, the container top. The unit also includes a cap. The cap has a lid and a moisture impervious layer attached to an inside portion of the lid. The lid can snap onto the container to hold the moisture impervious layer against a fixed surface forming a moisture barrier.
This application involves detecting luminescence. Various methods and devices are described that reduce interference of ambient light, including UV radiation, on test results. Such methods and devices include using UV blocking material and covering test components prior to use.
The present invention relates to a method for adjusting the sensitivity of a microbial culture to an antibiotic. The method employs a substance derived from a bacterial species with sensitivity to the antibiotic. Such bacterial species include the same species used in the culture or a different species.
An antibody and immunogen for generating an antibody to nitrofuran and/or nitrofuran metabolite such as tissue or protein bound nitrofuran metabolites. Nitrofurans and and/or nitrofuran metabolites in a biological sample can be detected by contacting the sample with the antibodies to form a complex that can be detected. The antibodies may also be incorporated into test kits for the detection of nitrofuran and/or nitrofuran metabolites.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
Diagnostic kits comprising biological or chemical reagents
for detecting microorganisms or chemicals in various
environments. Scientific instruments, software and computers for use in
detecting microorganisms or chemicals in various
environments.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
Diagnostic kits comprising biological or chemical reagents for detecting microorganisms or chemicals in various environments for non-medical purposes Diagnostic kits comprising biological or chemical reagents for detecting microorganisms or chemicals in various environments for medical or veterinary purposes Scientific instruments, namely radiation detectors, namely scintillation counters; electrical adapters; bar code readers; bar code scanners; battery cases; battery chargers; chromatography columns; wireless communication devices; laboratory apparatuses namely centrifuges and pipette tips; laboratory equipment and supplies namely incubators, test tubes and thermometers; laboratory equipment namely pipette racks; optical readers; photometers; printers; timers; computer software and computer hardware for use in detecting chemicals or microorganisms in various environments
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
Diagnostic kits comprising biological or chemical reagents for detecting microorganisms or chemicals in various environments Scientific instruments, namely radiation detectors, namely scintillation counters; electrical adapters; bar code readers; bar code scanners; battery cases; battery chargers; chromatography columns; interfaces for detectors; laboratory apparatuses namely centrifuges and pipette tips; laboratory equipment and supplies namely incubators, test tubes and thermometers; laboratory equipment namely pipette racks; optical readers; photometers; printers; timers; computer software and computer hardware for use in detecting chemicals or microorganisms in various environments
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Kit for use in detecting biological or chemical residue on a surface the test kit composed of a container with test reagents therein for use in detecting said biological or chemical residues, and a swab to obtain a test sample
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Assay for analyte detection and reagents therefor.
(2) Instruments for use in the analysis of milk and other foods and food products, for the detection of antibiotics, toxins, and other contaminating residues, namely, incubators, data processors, optical scanners, computer chips, light emitting diodes, luminescent display panels, computer memory, micro-processors, micro-computers, optical mirrors, computer operating systems, computer software, computer programs, power supplies, signal processors, thermometers, and thermostats and printers.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
assay kits comprising reagents and/or test strips for use in detecting antibiotics, toxins, and other contaminates in milk and other foods and food products instruments for use in the analysis of milk and other foods and food products, for the detection of antibiotics, toxins, and other contaminating residues, namely, incubators, data processors, optical scanners, computer chips, light emitting diodes, luminescent display panels, computer memory, micro-processors, micro-computers, optical mirrors, computer operating systems, computer software, computer programs, power supplies, signal processors, thermometers, and thermostats and printers
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Testing apparatus and instruments, namely, hand-held testing apparatus and instruments, namely, a kit composed of a tube containing test chemicals with a swab, used to collect test samples associated with food and biologics; photometers and incubators for the analysis of test samples.
