A system to generate power in a low orbit environment may include an enclosure configured to maintain a noble gas radioisotope at a threshold pressure, wherein the noble gas radioisotope generates heat at the threshold pressure, a radiator configured to maintain the generated heat at a threshold heat, and a power converter configured to convert the maintained heat to electric power.
G21H 1/10 - Cells in which radiation heats a thermoelectric junction or a thermionic converter
G21H 3/00 - Arrangements for direct conversion of radiation energy from radioactive sources into forms of energy other than electric energy, e.g. light
Gravity map based navigation is provided. A system (100) can include a data processing system (115) including one or more processors (535), coupled with memory (515). The data processing system (115) can retrieve, based on an estimated position (175) of the system (100), a value of gravity (160) from values of gravity mapped to positions (155). The data processing system (115) can determine an altitude (187) of the system (100) based on at least the value of gravity (160) and a force measured by an accelerometer (125) of the system (100). The data processing system (115) can compare the altitude (187) with a reference altitude (165) to determine an altitude error measurement (197). The data processing system (115) can determine a lateral position of the system (100) based on the altitude error measurement (197).
G01C 21/16 - Navigation; Navigational instruments not provided for in groups by using measurement of speed or acceleration executed aboard the object being navigated; Dead reckoning by integrating acceleration or speed, i.e. inertial navigation
3.
PRINTHEAD AND SYSTEM FOR ELECTROPORATION, AND METHOD OF PRINTING PATTERNED TISSUE
A method of printing patterned tissue includes flowing a bioink comprising cells and a biological cargo through a nozzle moving relative to a substrate and exposing selected voxels of the bioink to a pulsed electric field as the bioink flows through the nozzle. Consequently, a portion or all of the cells in each of the selected voxels undergoes electroporation and transfection with the biological cargo. A cell-laden filament comprising the bioink and including the selected voxels is continuously extruded from an outlet of the nozzle, and, as the nozzle moves relative to the substrate, the cell-laden filament is deposited in a predetermined pattern on the substrate. Thus, a tissue having spatial patterns of gene expression may be printed.
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
B41J 2/005 - Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by bringing liquid or particles selectively into contact with a printing material
A micro heat engine for utilizing temperature differential for high efficiency heat conversion, may include a housing have a hot side and a cold side, a plurality of pistons arranged within the housing, each extending from the hot side to the cold side; and a plurality of regenerators, each configured to be arranged between two adjacent pistons and configured to store heat generated as working gas moves within the adjacent pistons.
F02G 1/043 - Hot gas positive-displacement engine plants of closed-cycle type the engine being operated by expansion and contraction of a mass of working gas which is heated and cooled in one of a plurality of constantly communicating expansible chambers, e.g. Stirling cycle type engines
5.
COVALENTLY MODIFIED TEMPLATE-INDEPENDENT DNA POLYMERASE AND METHODS OF USE THEREOF
Provided herein are engineered terminal deoxynucleotidyl transferase (TdT) proteins with certain modifications, including mutations to confer thermal stability and to install an exposed amino acid residue to which a small molecule can be covalently tethered via bioconjugate chemistries such as click chemistry. Also provided herein are methods of nucleic acid molecule synthesis using engineered TdTs and nucleotide molecules attached to redox-cleavable linkers, wherein the engineered TdT incorporates the nucleotide molecule into a nucleic acid strand and is separated from the nucleotide molecule when the redoxcleavable linker is cleaved upon exposure to suitable electrochemical conditions. Also provided herein are engineered TdTs covalently attached to a nucleotide molecule via a tether and also nucleotide molecules comprising a redox-cleavable linker. Further provided herein are systems for enzymatic DNA synthesis comprising an engineered TdT, a redox-cleavable linker a redox shuttle solution, and two or more electrodes.
A system for calorimetry includes a plurality of wells disposed upon a well plate, an input feature to deposit a sample within each well, and light sources configurable to irradiate each of the wells in the well plate, and their samples, with incident light. A photonic sensor chip at a bottom of each well includes a plural nanohole array sensor on a substrate. A light detector positioned below the well is configured to measure the transmission of light through the sensors, obtaining a series of optical transmission measurements. A heater is in thermal contact with each of the wells, applying a transient thermal increase to each well, and the sample therein, at a known heat rate. A processor is configured to calculate a measurement for each well as a function of the series of optical transmission measurements and the transient thermal increase, the measurement being indicative of the sample within the well undergoing a change in response to the transient thermal increase, the change relating to a property of the sample.
G01N 25/48 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
A system can include a balloon catheter, a pump, a pressure sensor, and one or more processors, The balloon catheter can be configured to be inserted into a lumen of a tissue. The pump can be configured to provide fluid into the balloon catheter to cause the balloon catheter to induce a radial stress of the tissue. The pressure sensor can be configured to detect a pressure of the fluid while the balloon catheter is inducing the radial stress of the tissue. The one or more processors can be configured to determine a characteristic of the tissue based at least on the pressure.
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
8.
METHOD OF ACOUSTOPHORESIS USING SELECTION PARTICLES THAT ALTER ACOUSTIC RESPONSE AND CORRELATED SYSTEM
A method of acoustophoresis using selection particles that alter acoustic response is provided. The method can include selecting a set of selection particles based on surface markers of a plurality of target particles to be separated using acoustophoresis. The method can include incubating the set of selection particles with the plurality of target particles in a solution such that the set of selection particles bind with the surface markers on the plurality of target particles to create a plurality of bound particles. The method can include providing the plurality of bound particles to an acoustophoresis device tuned to separate the particles based on a net acoustic contrast between each of the plurality of bound particles. The method can include receiving a plurality of output streams from the acoustophoresis device that each include a respective bound particle of the plurality of bound particles.
A Fano resonator device can be used to sequence DNA or other macromolecules. The device includes customized molecular components, informed by computation analysis. Techniques for preparing and using the device also are disclosed. The device can be incorporated in a system that further includes a sample processing component and a flow chamber.
G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
Devices for treatment of cells are disclosed. The devices include an elongated housing and at least one hollow fiber semi-permeable membrane positioned within the housing having a plurality of pores dimensioned to prevent passage of the cells to be treated. Systems for treatment of cells including the device are disclosed. Methods of treating cells, including transducing cells and activating cells, are also disclosed. The methods include introducing a biosample with cells to be treated into the device, introducing media to suspend and release treated cells into the device, and discharging the treated cells from the device.
A biocompatible adhesive is disclosed. The biocompatible adhesive includes a substrate and a plurality of micro-scale elements extending from a surface of the substrate having a length selected to puncture a layer of a target tissue or target material. At least some of the micro-scale elements include at least one protrusion dimensioned to anchor the biocompatible adhesive to the target tissue or target material. A medical device assembly is also disclosed. The medical device assembly includes the biocompatible adhesive coupled to a surface of a component of the medical device assembly and positioned to attach the medical device assembly to the target tissue or target material. A method of facilitating attachment of a medical device assembly to a target tissue is also disclosed. A method of facilitating treatment of a wound is also disclosed.
A method for separating cells in a biofluid includes pretreating the biofluid by introducing a predetermined amount of a cocktail of antibodies, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the pretreated biofluid within the microfluidic separation channel. A system for microfluidic cell separation, capable of separating target cells from non-target cells in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of an additive including the cocktail of antibodies, and at least one acoustic transducer coupled to the microfluidic separation channel. A kit for microfluidic cell separation is also disclosed. A method of facilitating separation of cells is also disclosed.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
13.
HIGHLY DEFORMABLE POROUS MEMBRANE CULTURE SYSTEM AND ACTUATION METHODS FOR STUDYING THE EFFECTS OF BIOMECHANICAL STRETCH ON CULTURED TISSUE
The systems and methods of the present disclosure provide highly deformable porous membrane culture systems and actuation methods for studying the effects of biomedical stretch on cultured tissue. A well plate can include a well having a first opening configured to receive an insert coupled to a deformable membrane. The well plate can include a gasket positioned within the well and configured to create a seal between the insert and the well when the insert is positioned in the well. The well plate can include a chamber defined beneath the well, the chamber configured to receive fluid media and to expose the fluid media to a surface of the deformable membrane when the insert is positioned in the well. The well plate can include an actuator configured to stretch the deformable membrane by a target amount of strain.
The systems and methods of the present disclosure provide techniques for the design and use of an intermediate or transitional plate or block designed to couple acoustic energy at a given frequency from a transducer, such as a piezoelectric transducer, to one or more acoustophoretic devices, such as microfluidic channels, such that driving the chip occurs with a controlled wavelength and symmetry. Such techniques provide improved efficiency when driving a single acoustophoretic device, or for multiple acoustophoretic devices to be operated in concert from a single transducer, and therefore without complex electronics. Additionally, the techniques described herein allow for relaxed design constraints when considering transducer selection and fabrication, instead transferring design constraints to the more easily customized actuation plate.
A microchannel cell culture device is disclosed. The microchannel cell culture device includes a well plate defining an array of tissue modeling environments. A cell culture system including the microchannel cell culture device is also disclosed. The cell culture system includes a plurality of optical sensors, a platform, and a light source. A method of high throughput screening cell biological activity with the microchannel cell culture device is disclosed. A method of measuring oxygen consumption rate of cells in the microchannel cell culture device is disclosed. A method of facilitating drug development with the microchannel cell culture device is also disclosed.
An antenna system has a two-dimensional field of view, yet can be implemented on a surface, such as on electronic or photonic integrated circuits. The antenna system includes an array of antennas disposed in a predetermined non-linear pattern and a two-dimensional beamforming network (BFN). The antenna system can be steered/selectively beamformed in two dimensions through beam port selection. The beamforming network is disposed entirely on a single first surface. The beamforming network has a one-dimensional array-side interface disposed on the first surface and a one-dimensional beam-side interface disposed on the first surface. The antennas of the array of antennas are individually communicably coupled to the array-side interface. Segments of the beam-side interface map to respective pixels in the two-dimensional field of view.
H01Q 3/40 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase by electrical means with phasing matrix
H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
H01Q 25/00 - Antennas or antenna systems providing at least two radiating patterns
H04B 7/06 - Diversity systems; Multi-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE NAVY (USA)
THE CHARLES STARK DRAPER LABORATORY, INC. (USA)
Inventor
Glaven, Sarah
Onderko, Elizabeth
Maygar, Andrew
Yates, Matthew
Abstract
Described herein are biofilm bioreactors for synthesis at the interface between two liquids, and methods of using such bioreactors for the biotransformation of feedstocks into chemical products. Also contemplated is the extraction of such products.
The present disclosure provides a handpiece (100) for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can be integrated with a micropump (1104) and a fluid reservoir (1106). The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. The micropump can include a self-contained fluid reservoir that can provide predetermined volumes of fluid to precise areas of the patient.
A61F 11/00 - Methods or devices for treatment of the ears or hearing sense ; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
A system for cell bioprocessing and cell therapy manufacturing can include a series of microfluidic modules to enable continuous-flow end-to-end cell bioprocessing. Each module can implement a different technology, and the modules can be coupled to one another to perform various unit operations in the cell bioprocessing or cell-therapy manufacturing chain to enable direct processing of a blood or blood product sample. The system can automatically and continuously process the sample into genetically-modified lymphocytes or T cells for cellular therapy. The technologies implemented by each module in the system can include any combination of microfluidic acoustophoresis, microfluidic acoustophoretic media exchange or cell washing, and continuous-flow microfluidic electrotransfection. Modules implementing these microfluidic technologies can be interconnected with plastic tubing or with a custom manifold.
The present solution provides systems and methods for trans-round window membrane drug delivery. As an overview, a system can include a micropump that is connected to a flexible cannula. The cannula can be threaded through a handpiece that can be used to pierce the round window membrane of a patient. Using the handpiece, the cannula can be inserted through the round window membrane to improve the distribution of the delivered drug throughout the inner ear. The present solution can function as a small implantable or wearable device that can be used for both chronic and acute trans-round window membrane drug delivery. With this configuration, the micropump can constantly or intermittently deliver, over a period of days to months, small volumes of drugs from an internal reservoir.
A61F 11/00 - Methods or devices for treatment of the ears or hearing sense ; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
A method for manufacturing a microfluidic device can include providing a base component to define a first portion of the microfluidic device. A cap component of the microfluidic device can be fabricated with a sealing lip extending a first distance from a first side of the cap component and a support portion extending a second distance, less than the first distance, from the first side of the cap component. The method can include positioning the cap component and the base component within a mold to bring the sealing lip of the cap component in contact with the base component. The base component, the support portion of the cap component, and the sealing lip of the cap component together can define a cavity. The method can include injecting a polymer material into the mold to cause the polymer material to fill the cavity.
MEMS-actuated optical switches can be implemented on photonic chips. These switches are compact, essentially planar, simple to implement and include only one moving MEMS component per switch. The switches exhibit low optical loss, require low power to operate, and are simple to control and easy to integrate with other optical devices. Each switch has two optical waveguides that are optically coupled in an ON switch state and not coupled in an OFF switch state. An end or a medial section of one of the two waveguides may translate between the ON and OFF states to affect the coupling. Alternatively, a coupling frustrator may translate between the ON and OFF states to affect the coupling.
G02B 6/35 - Optical coupling means having switching means
G02B 6/12 - Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
23.
SYSTEMS AND METHODS FOR INTEGRATING SENSORS WITH PUMPS IN A MICROFLUIDIC DEVICE
This disclosure provides systems and methods for integrating an array of electronic sensors capable of performing trans-epithelial electrical resistance (TEER) measurements into a microfluidic device that includes a well plate. In some implementations, the sensors can include electrodes that are submerged into fluidically connected wells of the microfluidic device, which can contain an electrically conductive fluid such as the cell culture media or a buffered salt solution. An array of such electrodes can be integrated into a lid of the system that includes the microfluidic device. These electrodes can be routed using a printed circuit board through a number of multiplex switches that can allow addressing of a desired unit of the device through a microprocessor in communication with a computer.
This disclosure provides systems and methods for seeding cell cultures in a microfluidic device. The systems and methods of this disclosure can enable flow of a cell solution from one side of a scaffold, such as a porous substrate or membrane, to the other side of the scaffold. Flow of the liquid can pass through the scaffold while the cells themselves do not, resulting in the cells driven to the surface of the scaffold for consequent attachment. A microfluidic device can include a microfluidic feature structured to create a seal between a cell seeding tool and an inlet to a microchannel of the microfluidic device. This can enable a pressure-driven flow to push fluid down the channel and through pores of the membrane. In contrast, traditional gravity fed seeding of cells may not create enough pressure to drive fluid through the pores of the scaffold.
A device, system and process involve conducting electroporation of microvesicles or exosomes or other target structures in a microfluidic arrangement at pressures that exceed atmospheric pressure. Single as well as multiple flow configurations can be employed. In some cases, the system and its operation are computer-controlled for partial or complete automation.
A LiDAR system (300) has a field of view (320) and includes a polarization-based waveguide splitter (308). The splitter (308) includes a first splitter port (306), a second splitter port (312) and a common splitter port (316). A laser (302) is optically coupled to the first splitter port (306) via a single-polarization waveguide (304). An objective lens (334) optically couples each optical emitter (326-330) of an array of optical emitters (322) to a respective unique portion of the field of view (320). An optical switching network (340) is coupled via respective dual-polarization waveguides (338) between the common splitter port (316) and the array of optical emitters (322). An optical receiver (314) is optically coupled to the second splitter port (312) via a dual-polarization waveguide (310) and is configured to receive light (336) reflected from the field of view (320). A controller (342), coupled to the optical switching network (340), is configured to cause the optical switching network (340) to route light from the laser (302) to a sequence of the optical emitters (326-330) according to a temporal pattern.
G01S 7/481 - Constructional features, e.g. arrangements of optical elements
G01S 7/499 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group using polarisation effects
A LiDAR system includes an array of optical emitters, an objective lens optically coupling each optical emitter to a respective unique portion of a field of view, an optical switching network coupled between a laser and the array of optical emitters and a controller coupled to the optical switching network and configured to cause the optical switching network to route light from the laser to a sequence of the optical emitters according to a dynamically varying temporal pattern and to vary the temporal pattern in a way that reduces risk of eye injury from the laser light.
A LiDAR system includes an array of optical emitters, an objective lens optically coupling each optical emitter to a respective unique portion of a field of view, an optical switching network coupled between a laser and the array of optical emitters and a controller coupled to the optical switching network and configured to cause the optical switching network to route light from the laser to a sequence of the optical emitters according to a dynamically varying temporal pattern and to vary the temporal pattern based at least in part on distance to an object within the field of view. The LiDAR system scans different portions of the field of view differently, such as with different laser power levels, different revisit rates and/or different scan patterns, for example based on likelihood of detecting objects of interest in the various portions or based on likely relative importance of objects likely to be found in the various portions.
In an embodiment, a method and system use various sensors to determine a shape of a collection of materials (e.g., foodstuffs). A controller can determine a trajectory which achieves the desired end-state, possibly chosen from a set of feasible, collision-free trajectories to execute, and a robot executes that trajectory. The robot, executing that trajectory, scoops, grabs, or otherwise acquires the desired amount of material from the collection of materials at a desired location. The robot then deposits the collected material in the desired receptacle at a specific location and orientation.
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewing; Safety devices combined with or specially adapted for use in connection with manipulators
30.
FOOD-SAFE, WASHABLE INTERFACE FOR EXCHANGING TOOLS
A problem with current food service robots is making the robots safe to work around food. A solution provided by the present disclosure is a food-safe tool switcher and corresponding tool. The tool switcher can mate with a variety of tools, which can be molded or 3D printed out of food-safe materials into a single-part, instead of constructed modularly. This provides for easier cleaning.
In an embodiment, a method includes determining a given material to manipulate to achieve a goal state. The goal state can be one or more deformable or granular materials in a particular arrangement. The method further includes, for the given material, determining, a respective outcome for each of a plurality of candidate actions to manipulate the given material. The determining can be performed with a physics-based model, in one embodiment. The method further can include determining a given action of the candidate actions, where the outcome of the given action reaching the goal state is within at least one tolerance. The method further includes, based on a selected action of the given actions, generating a first motion plan for the selected action.
In an embodiment, a method during execution of a motion plan by a robotic arm includes determining a voice command from speech of a user said during the execution of the motion plan, determining a modification of the motion plan based on the voice command from the speech of the user, and executing the modification of the motion plan by the robotic arm.
An adaptor (200) comprising an element having a first interface component (404) and second interface component (415) wherein the first interface component (404) is configured to removably mate with a connector (112) of a robot (110) and the second interface component (415) is configured to attach to a tool (108).
B25J 11/00 - Manipulators not otherwise provided for
A47J 43/28 - Other culinary hand implements, e.g. spatulas, pincers, forks or like food holders, ladles, skimming ladles, cooking spoons; Spoon-holders attached to cooking pots
34.
CONTROLLING ROBOT TORQUE AND VELOCITY BASED ON CONTEXT
In an embodiment, a method includes identifying a force and torque for a robot to accomplish a task and identifying context of a portion of a movement plan indicating motion of the robot to perform the task. Based on the identified force, torque, and context, a context specific torque is determined for at least one aspect of the robot while the robot executes the portion of the movement plan. In turn, a control signal is generated for the at least one aspect of the robot to operate in accordance with the determined context specific torque.
Embodiments provide functionality to prevent collisions between robots and objects. An example embodiment detects a type and a location of an object based on a camera image of the object, where the image has a reference frame. Motion of the object is then predicted based on at least one of: the detected type of the object, the detected location of the object, and a model of object motion. To continue, a motion plan for the robot is generated that avoids having the robot collide with the object based on the predicted motion of the object and a transformation between the reference frame of the image and a reference frame of the robot. The robot can be controlled to move in accordance with the motion plan or a signal can be generated that controls the robot to operate in accordance with the motion plan.
In an embodiment, a cover for an automated robot includes elastic sheets that are adhered to each other in a geometry. The geometry is configured to allow the elastic sheets to expand and contract while the automated robot moves within its range of motion. The elastic sheets are attached to the automated robot by elasticity of the elastic sheets. A first group of the elastic sheets forms an elastic collar configured to grip the automated robot at a distal end and a proximal end of the cover. A person of ordinary skill in the art can recognize that nonbreakably means that during operation of the robot, the elastic sheets hold their elasticity and integrity without breaking.
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewing; Safety devices combined with or specially adapted for use in connection with manipulators
Embodiments provide methods and systems to modify motion of a robot based on sound and context. An embodiment detects a sound in an environment and processes the sound. The processing includes comparing the detected sound to a library of sound characteristics associated with sound cues and/or extracting features or characteristics from the detected sound using a model. Motion of a robot is modified based on a context of the robot and at least one of: (i) the comparison, (ii) the features extracted from the detected sound, and (iii) the characteristics extracted from the detected sound.
In an embodiment, a method for handling an order includes determining a plurality of ingredients based on an order, received from a user over a network, for a location having a plurality of robots. The method further includes planning at least one trajectory for at least one robot based on the plurality of ingredients and utensils available at the location, and proximity of each ingredient and utensil to the at least one robot. Each trajectory can be configured to move one of the plurality of ingredients into a container associated with the order. In an embodiment, the method includes executing the at least one trajectory by the at least one robot to fulfill the order. In an embodiment, the method includes moving the container to a pickup area.
Current technologies allow a robot to acquire a tool only if the tool is in a set known location, such as in a rack. In an embodiment, a method and corresponding system, can determine the previously unknown pose of a tool freely placed in an environment. The method can then calculate a trajectory that allows for a robot to move from its current position to the tool and attach with the tool. In such a way, tools can be located and used by a robot when placed at any location in an environment.
Transfer of genetic and other materials to cells is conducted in a hands-free, automated, high throughput, continuous process. A system using a microfluidic hydrodynamic sheath flow configuration includes arrangements for pushing cells from side streams containing a cell culture medium to a central stream containing an electroporation buffer. Electroporation can be conducted in an assembly in which two or more microfluidic channels are provided in a parallel configuration and in which various layers can be stacked together to form a laminate type structure.
A well reader and actuator (100) for a well array (50) has an array of detectors, each detector for detecting a fluorescence signal from fluorophores in a respective well of the well array and an excitation subsystem for exciting the fluorophores in the wells of the well array. Embodiments of this invention can be used to carry out two important functions in a highly parallel manner: by addressing individual wells in a 32, 96, 384 etc. well array, where each well contains a potential chemical or biological reaction. The two functions are: 1) through thermal, optical or other means and combinations thereof the rate of a chemical or biological reaction is controlled or gated (e.g. colder wells inhibit a reaction, or an enzymatic reaction requires blue light to proceed); and 2) through use of fluorescent species that are sensitive to the target reaction - or reactions - an optical readout of fluorescent intensity and/or lifetime is tracked to monitor the evolution of the reaction.
Local terrain feature location data is obtained from a local sensor device at a user location without a prior-known global position. The local terrain feature location data characterizes relative distances and directions to a plurality of local terrain features nearest to the user location. Global terrain feature location data stored in at least one hardware memory device is accessed. The global terrain feature location data characterizes relative distances and directions between a plurality of distinctive terrain features located in a defined terrain region in terms of absolute global location coordinates. The local terrain feature location data is compared to the global terrain feature location data to develop multiple pattern matching hypotheses, wherein each pattern matching hypothesis characterizes a likelihood of a subset of the local terrain features matching a subset the global terrain features. Global location coordinates for the user location is then determined from the pattern matching hypotheses.
G01S 5/16 - Position-fixing by co-ordinating two or more direction or position-line determinations; Position-fixing by co-ordinating two or more distance determinations using electromagnetic waves other than radio waves
G01S 17/46 - Indirect determination of position data
G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
G01C 21/00 - Navigation; Navigational instruments not provided for in groups
The present disclosure describes a system, device and method for differentiating cells such as, for example, generating ex vivo common lymphoid progenitors (CLPs) from human hematopoietic stem cells (HSCs). The system and method can be fully automated requiring minimal touch input from a user. Once harvested, the CLPs can be transplanted into a patient for cellular immune therapy.
A method of lidar processing pulses a scene with laser pulse sequences from a laser light source. Reflected light (201) from the target scene (105) passes through receiver optics (202) and is defocused to cover a light sensing surface (205) of a photo detector array (204). The photo detector array (204) contains multiple photon detector elements connected in parallel where each photon detector element is configured to generate corresponding photon pulse output signals based on sensing photons in the received reflected light, and each photon detector element is characterized by a non-responsive dead time period immediately after sensing a photon. The defocused light (203) is intended to spread the optical power of the incoming light over many of the individual photo detectors. The photon pulse output signals are combined to form a common real time output signal, which is converted to a digital time resolved histogram. Multiple digital time resolved histograms produced in response to multiple light pulses directed at a scanning location are combined to form a composite time resolved histogram for the scanning location. In an embodiment, the receiver optics (202) is a lens having a focal plane positioned beyond the light sensing surface (205) so that defocused light (203) hits and covers the light sensing surface (205). A high speed analog-to-digital converter (206) converts the signal to a digital indication of a number of photons received in each time bin. A lidar processor (207) can combine the digital time resolved histograms for the scanning location into a composite time resolved histogram for the location.
A method of lidar imaging pulses a scene with laser pulse 102 sequences from a laser light source 101. A receiver detector 108 converts the received reflected light 107 into a time-resolved signal for each of the laser pulses. Reflected light from the scene is measured for each laser pulse to form a sequence of time resolved light signals. Adjoining time bins in the time resolved light signals are combined to form super time bins. A three dimensional image of the scene is created from distances determined based on maximum intensity super time bins. One or more objects 105 are located within the image using a detection algorithm. For each object 105, the time resolved light signals are combined by summing or averaging to form a single object time resolved light signal from which to determine distance to the object. This process can be applied to the original sized time bins of the time resolved light signals to recover the high speed temporal resolution. In addition, measuring the reflected light also may include detrending or high-pass filtering the time resolved light signals to offset scattering effects due to fog or other interfering factors which may obscure an ability to obtain precise distances, and to isolate the sharp return from the target object in the measured reflected light.
A parallelized chain-synthesizing technique includes capillary tubes, where each tube provides multiple locations or addresses where a specific arbitrary sequence for polymeric chains can be synthesized. An optical addressing system selectively delivers light to the locations to mediate or control reactions in the tubes.
An embedded energy storage system comprises an array of embedded storage solar cells and a panel combiner/converter configured to combine and coordinate the array of embedded storage solar cells. Each of the array of embedded storage solar cells may comprise a solar cell having a first surface that is light receptive and a second surface that is not light receptive, an array of micro super-capacitors (MSCs) disposed on a substrate, and one or more integrated circuit components disposed on the same or different substrate. If disposed on different substrates, the two substrates may be intimately connected using an advanced packaging technology. The substrate may be arranged to overlay the second surface of the solar cell, substantially adjacent to the second surface, with two or more electrical conductors configured to electrically couple the substrate to the solar cell.
A system for sequential exposure of particles to different fluid streams includes an acoustic actuator device for acoustically driving one or more substrates and a microchannel device of the one or more substrates that receive particles in a first flowing fluid, moves the particles to a second flowing fluid, then moves the particles out of the second flowing fluid using acoustic radiation generated by the acoustic actuator device. The system can control residence times in the streams. According to one use, the first flowing fluid is a cell buffer and the second flowing media is an electroporation buffer. An electroporation system is placed in or downstream of the acoustic actuator device. However, in other uses, the second flowing media might be a wash buffer.
A viral transduction and/or electroporation device has s a membrane separating two chambers and two electroporation electrodes for the chambers. An electrical voltage source is used for establishing an electrical field across the membrane and between the two electrodes. In operation, fluid is flowed into the chambers including fluid containing electroporation cargo and viral transduction solution and an electrical field is established across the membrane and between the electrodes to electroporate cells pinned to the membrane and transfecting the cells.
A system and method of LIDAR imaging to overcome scattering effects pulses a scene with light pulse sequences from a light source. Reflected light from the scene is measured for each light pulse to form a sequence of time-resolved signals. Time-resolved contrast is calculated for each location in a scene. A three-dimensional map or image of the scene is created from the time-resolved contrasts. The three-dimensional map is then utilized to affect operation of a vehicle.
G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
G01S 7/48 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group
G01S 17/93 - Lidar systems, specially adapted for specific applications for anti-collision purposes
An electrostatic motor includes a cylindrical rotor and a stator. Electrodes are disposed on an inside cylindrical surface of the stator. Electrets and/or electrically conductive electrodes are disposed on the cylindrical rotor and a dielectric fluid fills space between the rotor and the stator to prevent discharge of the electrets. A mask is used to charge portions of an electret cylinder or other curved surface.
A system and method of processing instructions may comprise an application processing domain (APD) and a metadata processing domain (MTD). The APD may comprise an application processor executing instructions and providing related information to the MTD. The MTD may comprise a tag processing unit (TPU) having a cache of policy-based rules enforced by the MTD. The TPU may determine, based on policies being enforced and metadata tags and operands associated with the instructions, that the instructions are allowed to execute (i.e., are valid). The TPU may write, if the instructions are valid, the metadata tags to a queue. The queue may (i) receive operation output information from the application processing domain, (ii) receive, from the TPU, the metadata tags, (iii) output, responsive to receiving the metadata tags, resulting information indicative of the operation output information and the metadata tags; and (iv) permit the resulting information to be written to memory.
G06F 21/52 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure
G06F 12/0875 - Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches with dedicated cache, e.g. instruction or stack
G06F 12/14 - Protection against unauthorised use of memory
G06F 15/76 - Architectures of general purpose stored program computers
G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
G06F 9/38 - Concurrent instruction execution, e.g. pipeline, look ahead
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
G06F 21/71 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure computing or processing of information
53.
SYSTEM AND METHOD FOR TRANSLATING MAPPING POLICY INTO CODE
A system including at least one processor programmed to translate a policy into policy code, wherein: the policy is provided in a policy language; the policy code is in a programming language that is different from the policy language; and the policy includes a statement that maps an entity name to one or more metadata symbols to be associated with an entity in a target system against which the policy is to be enforced.
G06F 21/51 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems at application loading time, e.g. accepting, rejecting, starting or inhibiting executable software based on integrity or source reliability
G06F 21/52 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure
54.
PLATFORM FOR EARLY DETECTION OF PATHOGEN INFECTION
A method for identifying an interaction between a pathogen and a biological agent includes providing a platform for supporting cell growth, seeding different interaction sites on the platform with different biological agents, perfusing the platform with a fluid that carries substances for promoting growth and maintenance of the cells, exposing all of the interaction sites to a solution containing viruses, and detecting evidence indicative of the interaction, the evidence comprising evidence indicative of a change in structure or composition of a medium at the interaction site. The biological agent includes cells alone or cells with another substance.
A system for providing biphasic stimulation is disclosed. The system includes an electrode, an antenna coupled to a transmitter, a capacitor, a power supply, a backscatter load selectively coupled to the antenna via a switching device, a plurality of switches, and a controller configured to control the switching device to output, by the antenna, an acknowledgement signal to the transmitter responsive to receiving the power. The controller is further configured to control the plurality of switches to electrically couple a first plate of the capacitor to the electrode to provide a first nerve stimulation signal having a first polarity, and electrically couple a second plate of the capacitor to the electrode to provide a second nerve stimulation signal having a second polarity opposite the first polarity. The system further includes a housing encapsulating the antenna, the capacitor, the power supply, the backscatter load, the switches, and the controller.
A coupling interface arrangement is described for a photonic integrated circuit (PIC) device. The PIC includes an interface coupling surface having optical grating elements arranged to form optical output locations that produce corresponding light output beams. A coupling lens couples the light output beams into a conjugate plane at a far-field scene characterized by one or more optical aberrations that degrade optical resolution of the light outputs. The optical grating elements are configured to correct for the one or more optical aberrations.
G02B 6/124 - Geodesic lenses or integrated gratings
57.
SYSTEM AND METHOD FOR IMAGING AND LOCALIZATION OF CONTRAST-ENHANCED FEATURES IN THE PRESENCE OF ACCUMULATING CONTRAST AGENT IN A BODY AND AMPLIFICATION OF FEATURES IN ULTRASOUND-GENERATED IMAGES
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
Inventor
Berlin, Andrew A.
Young, Mon Y.
Abstract
This invention provides a system and method for background removal from images acquired by an ultrasound scanner in the presence of molecularly bound contrast agent. The system and method employs novel techniques that are compatible with the real-world constraints (i.e. energy levels, duration of exam, geometries involved, etc.) of imaging in mammalian tissue (e.g. tissues of human organs containing lesions/tumors), while providing the dramatically improved signal clarity required to reliably disambiguate contrast agent from other sources of signal intensity.
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
G01S 7/52 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
58.
SYSTEM AND METHOD FOR GUIDING INVASIVE MEDICAL TREATMENT PROCEDURES BASED UPON ENHANCED CONTRAST-MODE ULTRASOUND IMAGING
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
Inventor
Berlin, Andrew, A.
Young, Mon, Y.
Abstract
This invention provides a system and method for guiding a surgical instrument based on information obtained using enhanced contrast-mode ultrasound. The enhanced information can be added to information or images obtained in one or more imaging modes. Various pieces of information can be combined and composited, including information regarding tumors, blood vessels, location information, confidence levels, and other information, and can be composited into operative imaging.
A MEMS optical switch-based LiDAR beam steering unit may comprise an optical switching array comprising two or more translatable optical switch gratings. The two or more translatable optical switch gratings may be arranged in a foveal pattern. Each of the two or more translatable optical switch gratings may have an associated MEMS structure operative to selectively translate the optical switch grating between a first position and a second position, and a first waveguide associated with the translatable optical switch grating. The grating being in the first position may cause the grating to be sufficiently close to the first waveguide to produce a strong optical coupling between the grating and the first waveguide. The grating being in the second position may cause the grating to be sufficiently far from the first waveguide to produce a weak optical coupling between the grating and the first waveguide.
According to various aspects and embodiments, a prosthetic valve assembly for controlling fluid flow in an annulus is provided. The prosthetic valve assembly includes a suture ring formed from two or more segments, where each segment is configured to attach to the annulus, and a leaflet subassembly that attaches to an inner portion of at least one segment of the suture ring. The leaflet subassembly includes at least one leaflet configured for controlling a flow of fluid through the prosthetic valve assembly.
A system of two or more implantable medical devices is configured to establish a wireless link between the two or more implantable medical devices and a device external to a body of a patient while the two or more implantable medical devices are implanted in the body of the patient.
A software instruction code repair system comprising an instruction code example pool. The example pool comprises a set of good instruction code examples and a set of bad instruction code examples. The software instruction code repair system further comprises a sequence-to-sequence (seq2seq) network that is configured to generate a corrected instruction code example, based on one example of the set of bad instruction code examples. The software instruction code repair system further comprises a discriminator configured to randomly select one of the corrected instruction code example and one instruction code example of the set of good instruction code examples to produce a selected instruction code example. The discriminator is further configured to make a determination that the selected instruction code example is most likely taken either the instruction code example pool or the seq2seq network.
A non-volatile memory device (VeSFlash) comprises a vertical slit field effect transistor (VeSFET) device comprising a semiconductor portion defining a source end, a drain end, and a slit portion between the source end and the drain end. The VeSFlash non-volatile memory device further comprises at least one floating gate coupled to a side of the slit portion through an insulating layer. The floating gate is coupled to a contact through a second insulating layer. The VeSFlash non-volatile memory device further comprises either another floating gate or an independent control gate. In the case of comprising a control gate coupled to a side wall of the slit portion through a third insulating layer, and the control gate further coupled to a second contact, it is configured to accommodate an access signal, and the floating gate configured to accommodate a data signal. In the case of comprising a second floating gate coupled to a side of the slit portion through a third insulating layer, further coupled to a second contact through a fourth insulating layer, the floating gates accommodate both the access and data signals.
A method of fabricating a semiconductor device comprises forming, within a single process flow on a silicon on insulator (SOI) wafer, at least one of an n channel, digital VeSFET, a p channel, digital VeSFET, an n channel, analog VeSFET and a p channel, analog VeSFET. The method may further comprise forming, on the SOI wafer, at least one of a JFET, a BJT and a LT-MOM capacitor. The method may further comprise forming the n channel, digital VeSFET, a p channel, digital VeSFET, an n channel, analog VeSFET, and a p channel, analog VeSFET, according to a periodic design based on a unit circle. The method may comprise modifying a design of the semiconductor node, according to a three-dimensional architecture, to form a modified semiconductor node, and fabricating the modified semiconductor node on substrate, along with at least one other node of a different node type.
H01L 21/84 - Manufacture or treatment of devices consisting of a plurality of solid state components or integrated circuits formed in, or on, a common substrate with subsequent division of the substrate into plural individual devices to produce devices, e.g. integrated circuits, each consisting of a plurality of components the substrate being other than a semiconductor body, e.g. being an insulating body
H01L 27/12 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being other than a semiconductor body, e.g. an insulating body
H01L 27/06 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including a plurality of individual components in a non-repetitive configuration
H01L 27/085 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only
65.
METHOD AND APPARATUS FOR ELECTROPORATION OF ACOUSTICALLY-ALIGNED CELLS
Transfer of genetic and other materials to cells is conducted in a hands-free, automated and continuous process that includes flowing the cells between electroporation electrodes to facilitate delivery of a payload into the cells, while acoustophoretically focusing the cells. Also described is a control method for the acoustophoretic focusing of cells that includes detecting locations of cells flowing through a channel, such as with an image analytics system, and modulating a drive signal to an acoustic transducer to change the locations of the cells flowing in the channel. Finally, an electroporation driver module is described that uses a digital to analog converter for generating an electroporation waveform and an amplifier for amplifying the electroporation waveform for application to electroporation electrodes.
This invention provides a system and method to propagate uncertainty information in a deep learning pipeline. It allows for the propagation of uncertainty information from one deep learning model to the next by fusing model uncertainty with the original imagery dataset. This approach results in a deep learning architecture where the output of the system contains not only the prediction, but also the model uncertainty information associated with that prediction. The embodiments herein improve upon existing deep learning-based models (CADe models) by providing the model with uncertainty/confidence information associated with (e.g. CADe) decisions. This uncertainty information can be employed in various ways, including (a) transmitting uncertainty from a first stage (or subsystem) of the machine learning system into a next (second) stage (or the next subsystem), and (b) providing uncertainty information to the end user in a manner that characterizes the uncertainty of the overall machine learning model.
A single photon detection circuit is described that includes a germanium photodiode that is configured with zero voltage bias to avoid dark current output when no photon input is present and also is configured to respond to a single photon input by generating a photovoltaic output voltage. A single electron bipolar avalanche transistor (SEBAT) has a base emitter junction connected in parallel with the germanium photodiode and is configured so that the photovoltaic output voltage triggers an avalanche collector current output.
A compressive/transform imager comprising a lens array positioned above input ports for collecting light into the input ports, waveguides routing the light from the input port to waveguide mixing regions (e.g. multi-mode interference couplers), and detectors for receiving outputs of the waveguide mixing regions.
G01S 17/36 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated with phase comparison between the received signal and the contemporaneously transmitted signal
G02B 6/43 - Arrangements comprising a plurality of opto-electronic elements and associated optical interconnections
H01Q 13/22 - Longitudinal slot in boundary wall of waveguide or transmission line
H01Q 15/04 - Refracting or diffracting devices, e.g. lens, prism comprising wave-guiding channel or channels bounded by effective conductive surfaces substantially perpendicular to the electric vector of the wave, e.g. parallel-plate waveguide lens
H01Q 19/17 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using reflecting surfaces wherein the surfaces are concave the primary radiating source comprising two or more radiating elements
H01Q 3/18 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system using mechanical relative movement between primary active elements and secondary devices of antennas or antenna systems for varying relative position of primary active element and a reflecting device wherein the primary active element is movable and the reflecting device is fixed
H01Q 3/40 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase by electrical means with phasing matrix
H01Q 3/44 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the electric or magnetic characteristics of reflecting, refracting, or diffracting devices associated with the radiating element
69.
APPARATUS AND METHOD FOR TRANS-ROUND WINDOW MEMBRANE DRUG DELIVERY
The present solution provides trans-round window membrane (RWM) drug delivery. As an overview, the system can include a micropump that is connected to a flexible cannula. The cannula can include a stiffened and sharpened tip to facilitate insertion through the RWM. The cannula can be inserted through the RWM to improve the distribution of the delivered drug throughout the inner ear. The present solution can function as a small implantable or wearable device that can be used for both chronic and acute trans-RWM drug delivery. With this configuration, the micropump can constantly or intermittently deliver, over a period of days to months, small volumes of drugs from an internal reservoir.
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61F 11/00 - Methods or devices for treatment of the ears or hearing sense ; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
70.
METABOLIC PRESSURE FOR STEM CELL DIFFERENTIATION AND PURIFICATION
Described herein are cell culture methods of producing hepatocytes, or mature, highly functional hepatocyte-like cells in vitro; cell culture media suitable for use in these methods; functional hepatocytes, or mature, highly functional hepatocyte-like cells produced by these methods; and cell compositions comprising hepatocytes, or mature, highly functional hepatocyte-like cells produced by these methods.
Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency.
An oligonucleotide is prepared by the controlled, iterative addition of nucleotides to seed molecules at a functionalized electrode on a digital microfluidic device (DMF). Droplets containing a payload such as specific nucleotides and/or an enzyme, terminal deoxynucleotidyl transferase (TdT), for example, are individually guided, via path electrodes, to the functionalized electrodes, where chains are grown by addition of one nucleotide at a time. The DMF device includes an input section, containing reservoirs for reagents, a reaction section for growing the nucleotide chains and an output section for collecting waste and product. Each unit electrode on the device can be individually and independently addressed.
A system for management and control of vehicles is disclosed. In one example, the system manages and controls air traffic of aerial vehicles such as unmanned aerial vehicles (UAVs). The vehicular system includes vehicles including sensors for gathering sensor data, and a distributed control system that controls and manages the vehicles using the sensor data.
A light steering system and method for diffractive steering of electromagnetic radiation such as visible light is disclosed. Embodiments of the light steering system include leaky-mode SAW modulators as light modulator devices. The SAW modulators preferably include reflective diffractive gratings. The gratings are mounted to/patterned upon an exit face that opposes an exit surface of the SAW modulator, in one example. Steering of light signals emitted from the SAW modulators in these systems can be accomplished by varying wavelength of light signals introduced to the SAW modulators, and/or by varying frequency of RF drive signals applied to the SAW modulators. In addition, light field generators that incorporate SAW modulators of the proposed light steering system within displays of the light field generators are also disclosed.
G02F 1/11 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on acousto-optical elements, e.g. using variable diffraction by sound or like mechanical waves
G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the position or the direction of light beams, i.e. deflection
A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.
C12M 1/40 - Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
C12M 1/00 - Apparatus for enzymology or microbiology
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
A system is described for multi-frequency ultrasonically-encoded optical tomography of target tissue. A light source generates light input signals to the target tissue. An ultrasound transducer array has ultrasound transducers each generating a different time-dependent waveform to form a plurality of ultrasound input signals to an imaging volume within the target tissue. An optical sensor senses scattered light signals from the imaging volume, wherein the scattered light signals include light input signals modulated by acousto-optic interactions with the ultrasound input signals. Spectral analysis of the scattered light signals is performed to create a three-dimensional image map representing biomarker characteristics of the target tissue.
A system is described for multi-frequency ultrasonically-encoded tomography of a target object. One or more probe inputs generate probe input signals to the target object. An ultrasound transducer array is placed on the outer surface of the target object and has multiple ultrasound transducers each generating a different time-dependent waveform to form a plurality of ultrasound input signals to a target probe volume within the target object. One or more sensors sense tomography output signals from the target probe volume, wherein the tomography output signals contain an interaction component generated by interaction of the probe input signals with the ultrasound input signals. A tomography analysis of the tomography output signals is performed to create a three-dimensional object map representing structural and/or functional characteristics of the target object.
A system is described for multi-frequency ultrasonically-encoded tomography of a target object. One or more probe inputs generate probe input signals to the target object. An ultrasound transducer array is placed on the outer surface of the target object and has multiple ultrasound transducers each generating a different time-dependent waveform to form a plurality of ultrasound input signals to a target probe volume within the target object. One or more sensors sense tomography output signals from the target probe volume, wherein the tomography output signals contain an interaction component generated by interaction of the probe input signals with the ultrasound input signals. A tomography analysis of the tomography output signals is performed to create a three-dimensional object map representing structural and/or functional characteristics of the target object.
A system and corresponding method are described for multi-frequency ultrasonically-encoded tomography of a target object. One or more probe inputs generate probe input signals to the target object. An ultrasound transducer array is placed on the outer surface of the target object and has multiple ultrasound transducers each generating a different time-dependent waveform to form a plurality of ultrasound input signals to a target probe volume within the target object. A photorefractive crystal mixes scattered light output signals from the target probe volume with an optical reference beam input to produce optical tomography output signals including ultrasound sum frequencies components. A photodetector senses the optical tomography output signals from the photorefractive crystal. A tomography analysis of the tomography output signals including the ultrasound sum frequencies components is performed to create a three-dimensional object map representing structural and/or functional characteristics of the target object.
An apparatus includes a nanophotonic cavity, a waveguide, a microfluidic channel, and a photon detector. The cavity and the waveguide are fabricated out of a wide band gap semiconductor with an index of refraction that provides index contrast with the synthesis medium. One arrangement includes a photonic crystal having walls defining a channel for directing fluid flow. A functionalized spot is disposed in the channel for being tethered to a seed molecule to which a plurality of mers will be added. The walls extend downstream of the functionalized spot by a length that is at least as long as said molecule when assembled. The molecule can be linearized by a suitable fluid flow.
Microfluidic devices and associated methods are disclosed. A microfluidic device includes a target entrainment channel and an effluent channel on opposing sides of a semipermeable membrane. A restrictor channel that is narrower than the effluent channel is interposed between the semipermeable membrane and the effluent channel. Fluid that flows from the target entrainment channel, through the semipermeable membrane and the restrictor channel to the effluent channel, pins target cells along the center of the target entrainment channel for electroporation using an electrode in the channel.
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
85.
DISTRIBUTED ANALYTICS SYSTEM FOR IDENTIFICATION OF DISEASES AND INJURIES
A distributed analytics system for identification and determination of disease and/or injuries is implemented on mobile computing devices carried by the users and a distributed computer network communicating with the mobile computing devices.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A computer-implemented method is described for detecting, identifying and locating an object feature in a ferromagnetic object. At least one hardware processor executes program instructions to: define a planned scan trajectory for scanning the ferromagnetic object with a sensor array comprising a plurality of magnetometer sensors, measure magnetic fields of the ferromagnetic object with the sensor array along an actual scan trajectory at locations adjacent to the ferromagnetic material to produce object scanning data representing magnetic characteristics of the ferromagnetic object along the actual scan trajectory. The actual scan trajectory includes deviation motion of the scanning array from the planned scan trajectory. The deviation motion is then compensated for to identify and locate the object feature in the ferromagnetic object.
G01N 27/85 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables for investigating the presence of flaws by investigating stray magnetic fields using magnetographic methods
87.
SYSTEMS AND METHODS FOR FABRICATING MICROFLUIDIC DEVICES
This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.
This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.
A multi-layered electronic device including two or more stacked metal conducting layers, a dielectric layer disposed between metal conducting layers, and at least one electrical connection extending between contact pads of metal conducting layers and through a through hole of the dielectric layer is provided. A system including at least one multi-layered electronic device, a satellite coupled to at least one multi-layered electronic device, and a controller hub electrically connected to the multi-layered electronic device via the satellite is also provided. A method of manufacturing the multi-layered electronic device including forming first and second first metal conducting layers, depositing a dielectric layer adjacent to the metal conducting layers, and connecting the metal conducting layers is also provided.
Improvements to atom interferometers. An improved atom interferometer has a single polarization-preserving fiber, coupled for propagation of beams of two Raman frequencies, and a parallel displacement beamsplitter for separating the laser beams into respective free-space-propagating parallel beams traversing at least one ensemble of atoms. A reflector generates one or more beams counterpropagating through the ensemble of atoms. Other improvements include interposing a beam-splitting surface common to a plurality of parallel pairs of beams counterpropagating through the ensemble of atoms, generating interference fringes between reflections of the beams to generate a detector signal; and processing the detector signal to derive at least one of relative phase and relative alignment between respective pairs of the counterpropagating beams.
G01B 11/27 - Measuring arrangements characterised by the use of optical techniques for testing the alignment of axes for testing the alignment of axes
G01C 19/58 - Turn-sensitive devices without moving masses
G01P 15/08 - Measuring acceleration; Measuring deceleration; Measuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values
A wire includes an elongate conductive core wire, an elongate insulating layer disposed on and surrounding the elongate conductive core wire, an elongate conductive shield wire disposed adjacent to the insulating layer and the elongate conductive core wire, an elongate conductive shield layer disposed on the insulating layer and on the conductive shield wire such that the elongate insulating layer, the elongate conductive core wire, and the elongate conductive shield wire are embedded in the elongate conductive shield layer, the elongate conductive shield wire being electrically connected to the elongate conductive shield layer.
Disclosed are systems, devices, apparatus, tools, coaxial cables, materials, methods, and other implementations that include a method comprising controllably stripping, through one or more applications of energy directed at a micro coaxial cable, a conductive shield layer of the micro coaxial cable to expose a portion of a core conductive wire of the micro coaxial wire, and controllably deforming the exposed portion of the core conductive wire of the micro coaxial wire through the one or more applications of energy.
H02G 1/12 - Methods or apparatus specially adapted for installing, maintaining, repairing, or dismantling electric cables or lines for removing insulation or armouring from cables, e.g. from the end thereof
H01L 23/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details of semiconductor or other solid state devices
H01R 43/28 - Apparatus or processes specially adapted for manufacturing, assembling, maintaining, or repairing of line connectors or current collectors or for joining electric conductors for wire processing before connecting to contact members, not provided for in groups
viavia semi-synthesis. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
According to various aspects and embodiments, a growth adaptive expandable stent is provided. The expandable stent includes a stent structure having a cylindrical shape that is self- expanding in a radial direction and includes a plurality of cylindrical rings disposed along a longitudinal axis of the stent structure. The stent structure is configured to exert a continuous outward radial force over time when implanted such that a diameter of the stent structure expands from a first value to a second value that is at least about 1.5 times the first value.
A61F 2/915 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
95.
COMPOSITION OF MATTER: ENGINEERING OF ESCHERICHIA COLI PHAGE K1E
The present disclosure provides compositions including recombinant KIE bacteriophages, methods for making the same, and uses thereof. The recombinant KIE bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
C12N 15/11 - DNA or RNA fragments; Modified forms thereof
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/70 - Vectors or expression systems specially adapted for E. coli
C12N 15/90 - Stable introduction of foreign DNA into chromosome
C12Q 1/18 - Testing for antimicrobial activity of a material
C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
A bandpass optical filter comprises a broadband optical diffuser and a narrowband anti-diffuser disposed in a common optical path with the broadband optical diffuser.
A navigation system that utilizes a discrete-time nonlinear filter to obtain a navigation solution using GPS signals and optional aiding sensor data is described. A nonlinear filter offers improved accuracy over linearized filters at low signal to noise ratios. A discrete-time nonlinear filter guarantees positive-definite calculated covariance matrices under all conditions without requiring any compensation or added parameters. The navigation system receives a modernized global navigation satellite system (GNSS) signal and correlates a digitized copy of the GNSS signal to generate ranging code measurements. A conditional probability density function for the code measurements is determined and used to calculate arbitrary moments of code delay and other expected values. The code measurements and the conditional probability density function are processed in a nonlinear tracking filter to generate recursive navigation state updates, which can be used by an output device, such as a display, to present navigation and tracking information.
A star tracker includes a lens slice, a pixelated image sensor, an ephemeral database and a processor configured to estimate attitude, orientation and/or location of the star tracker based on an image of one or more celestial objects projected by the lens slice onto the pixelated image sensor. The lens slice is smaller and lighter than an optically comparable conventional lens, thereby making the star tracker less voluminous and less massive than conventional star trackers. A lens slice is elongated along one axis. Optical performance along the elongation axis is comparable to that of a conventional circular lens of equal diameter. Although optical performance along a width axis, perpendicular to the elongation axis, of a lens slice can be significantly worse than that of a conventional lens, use of two orthogonal lens slices provides adequate optical performance in both axes, and still saves volume and mass over a conventional lens.
G01S 3/786 - Systems for determining direction or deviation from predetermined direction using adjustment of orientation of directivity characteristics of a detector or detector system to give a desired condition of signal derived from that detector or detector system the desired condition being maintained automatically
G01S 3/781 - Direction-finders for determining the direction from which infrasonic, sonic, ultrasonic, or electromagnetic waves, or particle emission, not having a directional significance, are being received using electromagnetic waves other than radio waves - Details
G02B 3/06 - Simple or compound lenses with non-spherical faces with cylindrical or toric faces
99.
TELESCOPE ARRAYS AND SUPERIMPOSED VOLUME GRATINGS FOR LIGHT FIELD GENERATION
Acousto-optical modulators, such as a SAW modulators, with telescope arrays and superimposed volume gratings for light field generation are disclosed. These devices can employ pixelated demagnification and have layers of output optics, such as reflective gratings and/or arrays of transmissive refractive or diffractive lenses that manipulate the light emitted by the SAW modulator. In other cases, superimposed volume gratings are used, in which pixilation occurs in angle space.
A well telemetry system supplies power to downhole sensor nodes (60) employed for obtaining telemetry data in oil wells. The nodes are held in the cement that lines the well and surround the casing (20). At the surface, an AC power unit (1510) is connected to the casing 2(0) and geological structure (50) that surrounds the cement (55). Power to nodes is supplied using an AC resonant circuit that generates standing waves of electrical power on the casing. Power from the standing waves is delivered to the nodes (60-1, 60-02) which are located at antinodes of the standing wave. The nodes are held in cement that surround the casing, with one of their two electrodes (65, 70) connected to the casing and the other connected to the cement or to geological structure.
E21B 47/12 - Means for transmitting measuring-signals or control signals from the well to the surface, or from the surface to the well, e.g. for logging while drilling
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