Abstract

Provided are products of manufacture fabricated or manufactured as medical devices such as an inhaler, an ionizer, an asthma "puffer-like" device, a nebulizer or a nasal spray device, a respirator or a ventilator, a warm or a hot air delivery device, and/or a CPAP (continuous positive air pressure) device or equivalent, for delivering one or a combination of medications or drugs, and optionally also warm or hot air, and optionally also ionized air. Said drug combinations include various combinations of antivirals, antiparasitics, antibacterials, and adjunct therapeutics, including at least one of Hydroxychloroquine, Chloroquine, Oseltamivir, Lopinavir, Ritonavir, Ribavirin, Favipiravir, Remdesivir, Azithromycin, Ivermectin, Doxycycline, and Opaganib or combinations thereof. Products of manufacture are used for treating, preventing, ameliorating, slowing the progress of, decreasing the severity of or preventing a microbial infection, such as bacterial and viral infections, including the common respiratory viruses such as influenza vims, respiratory syncytial vims, picornavims, parainfluenza vims, adenovims, rhinovims, human metapneumovims, hantavimses, enterovims, a coronavims infection, or a COVID-19 or a 2019-nCoV (SARS-CoV-2) infection, or an infection caused by a vims in the subfamily Orthocoronavirinae, or a vims in the family Coronaviridae, or a vims in the order Nidovirales. In alternative embodiments, products of manufacture as provided herein administer combinations, or cocktails, of a dmg or dmgs by inhalation, for example, by use of aerosol, mist, liquid or powder formulations for inhalation.

IPC Classes  ?

• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 31/4965 - Non-condensed pyrazines
• A61K 31/593 - 9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
• A61K 31/65 - Tetracyclines
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
• A61K 33/245 - BismuthCompounds thereof
• A61K 33/30 - ZincCompounds thereof
• A61M 15/00 - Inhalators
• A61M 15/02 - Inhalators with activated or ionized gasesOzone-inhalators
• A61M 15/08 - Inhaling devices inserted into the nose
• A61M 16/10 - Preparation of respiratory gases or vapours
• A61P 31/14 - Antivirals for RNA viruses

Abstract

Therapeutic agents, combination therapies, and methods for the treatment of coronavirus infections and associated diseases, particularly COVID-19, are provided. The provided therapeutics include oseltamivir, lopinavir, ritonavir, chloroquine or hydroxychloroquine, azithromycin, clarithromycin, doxycycline, ivermectin, and combinations thereof.

IPC Classes  ?

• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 31/593 - 9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
• A61K 31/65 - Tetracyclines
• A61K 33/30 - ZincCompounds thereof
• A61P 31/14 - Antivirals for RNA viruses

Goods & Services

Drugs and pharmaceuticals preparations for medical purposes for the treatment of viral infections; vitamins.

Abstract

Detection of urease in gastric samples is achieved by using a composition comprising urea and an indicator. This composition can be provided in the form of a liquid or in a number of dry formats including a wafer, impregnated material, coated well or a tablet. The assay can be performed in described apparatus comprising a well which can be provided with a removable air-tight seal. In one optional form, the well may have a swaged rim for retaining a disc or ring inside the well and hinged plugs. This assay is useful for detecting H. pylori related gastrointestinal conditions.

IPC Classes  ?

• C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease
• C12M 1/24 - Apparatus for enzymology or microbiology tube or bottle type
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups