Abstract

A method for providing information about whether a knee is abnormal according to an embodiment comprises: a preprocessing step for extracting a first image set including skin contour information by processing each of a plurality of pieces of medical image data obtained by imaging a knee region; a step for generating a knee abnormality determination model by performing training on the basis of the first image set; a step for inputting, to the abnormality determination model, a diagnostic image including skin contour information in a knee region of a subject; and a step for outputting, from the abnormality determination model, information about whether a knee of the subject is abnormal.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

A sleep state feedback system of the present disclosure may comprise: a server for storing glaucoma diagnosis information; a mobile device carried by a glaucoma patient; and a wearable device worn by the glaucoma patient during sleep. The wearable device may estimate sleep postures of a glaucoma patient by using a sensing unit and generate sleep pattern data on the basis of the sleep postures and sleep duration. The server may generate feedback data on the basis of the sleep pattern data and the glaucoma diagnosis information. The mobile device may provide, to the glaucoma patient, at least one of a wake-up alarm and sleep coaching on the basis of the feedback data.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/024 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient for determining the visual field, e.g. perimeter types
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

The present disclosure relates to a system, a server, and a method that: accurately measure a user's corneal shape; enable tracking of a gaze direction while assisting in the selection of an intraocular lens on the basis of the corneal shape; and, in the case of dry eyes where the tear film is unstable and a single measurement may be inaccurate, improve the accuracy of corneal shape measurement by performing 24-hour measurement using an infrared-based Placido ring-shaped light source according to the present disclosure, and enable same to be used for gaze direction tracking.

IPC Classes  ?

• A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• A61F 2/16 - Intraocular lenses
• A61F 9/007 - Methods or devices for eye surgery

Abstract

The present disclosure relates to an artificial intelligence-based apparatus and method for examining and diagnosing an ovarian frozen section, the apparatus comprising: a memory; and a processor including an artificial intelligence engine for examining and diagnosing the ovarian frozen section, wherein the processor may obtain a first frozen section image of the ovary, obtain a second frozen section image corresponding to the first frozen section image of the ovary, and generate and provide a diagnosis result for frozen section examination of the ovary on the basis of the first frozen section image and the second frozen section image by using the artificial intelligence engine.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06T 3/18 - Image warping, e.g. rearranging pixels individually
• G06N 20/20 - Ensemble learning
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

The present disclosure relates to an artificial intelligence-based breast cryosection inspection and diagnosis apparatus and method, the apparatus comprising: a memory; and a processor including an artificial intelligence engine for breast cryosection inspection and diagnosis, wherein the processor acquires a first cryosection image of the breast, acquires a second cryosection image corresponding to the first cryosection image of the breast, and uses the artificial intelligence engine so as to generate and provide a diagnosis result for the breast cryosection inspection on the basis of the first cryosection image and the second cryosection image.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06T 3/18 - Image warping, e.g. rearranging pixels individually
• G06N 20/20 - Ensemble learning
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

The present disclosure relates to an artificial intelligence-based brain cryosection inspection and diagnosis device and method, the device comprising a memory, and a processor including an artificial intelligence engine for the brain cryosection inspection and diagnosis, wherein the processor can acquire a first cryosection image of the brain, acquire a second cryosection image corresponding to the first cryosection image of the brain, and use the artificial intelligence engine so as to generate and provide a diagnosis result for the brain cryosection inspection on the basis of the first cryosection image and the second cryosection image.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06N 20/20 - Ensemble learning
• G06T 3/18 - Image warping, e.g. rearranging pixels individually
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

The present invention relates to an artificial intelligence-based lung frozen section examination and diagnosis device and method. The device comprises: a memory; and a processor including an artificial intelligence engine for lung frozen section examination and diagnosis. The processor can obtain a first frozen section image of a lung, obtain a second frozen section image corresponding to the first frozen section image of the lung, and generate and provide a diagnosis result for a frozen section examination of the lung on the basis of the first frozen section image and the second frozen section image by using the artificial intelligence engine.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06T 3/18 - Image warping, e.g. rearranging pixels individually
• G06N 20/20 - Ensemble learning
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

The present disclosure relates to an artificial intelligence-based apparatus and method for examining and diagnosing a thyroid frozen section, and the apparatus includes: a memory; and a processor including an artificial intelligence engine for examining and diagnosing the thyroid frozen section, wherein the processor may obtain a first frozen section image of the thyroid, obtain a second frozen section image corresponding to the first frozen section image of the thyroid, and generate and provide a diagnosis result for a frozen section examination of the thyroid on the basis of the first frozen section image and the second frozen section image by using the artificial intelligence engine.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06T 3/18 - Image warping, e.g. rearranging pixels individually
• G06N 20/20 - Ensemble learning
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

The present disclosure relates to an artificial intelligence-based device and method for inspecting and diagnosing a frozen section of a lymph node, and the present device may include: a memory; and a processor including an artificial intelligence engine for the inspection and diagnosis of the frozen section of the lymph node, wherein the processor acquires a first frozen section image of the lymph node, acquires a second frozen section image corresponding to the first frozen section image of the lymph node, and generates and provides a diagnosis result for the inspection of the frozen section of the lymph node on the basis of the first frozen section image and the second frozen section image by using the artificial intelligence engine.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06N 20/20 - Ensemble learning
• G06T 3/18 - Image warping, e.g. rearranging pixels individually
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

The present disclosure relates to a device and method for optimizing a work process pertaining to a molecular pathology test on the basis of artificial intelligence. The device comprises: a reception unit that receives data related to the molecular pathology test; an artificial intelligence model training unit that trains, by means of a training data set, an artificial intelligence model by using a plurality of pieces of data related to the molecular pathology test as the training data set; and a work process prediction unit that inputs the data related to the molecular pathology test to the trained artificial intelligence model to predict, with the output of the trained artificial intelligence model, a work process corresponding to a work schedule.

IPC Classes  ?

• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 10/00 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data
• G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
• G06N 20/00 - Machine learning
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06N 3/08 - Learning methods

Abstract

The present disclosure relates to an artificial intelligence-based apparatus and method for pancreatic frozen section examination and diagnosis. The apparatus comprises: a memory; and a processor including an artificial intelligence engine for the pancreatic frozen section examination and diagnosis, wherein the processor can acquire a first frozen section image of the pancreas, acquire a second frozen section image corresponding to the first frozen section image of the pancreas, and generate and provide a diagnosis result for the pancreatic frozen section examination on the basis of the first frozen section image and the second frozen section image by using the artificial intelligence engine.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06N 20/20 - Ensemble learning
• G06T 3/18 - Image warping, e.g. rearranging pixels individually
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

The present disclosure relates to a lipid nanoparticle composition including a gallic acid derivative lipid and a use thereof, wherein it is possible to improve delivery efficiency and immune effect by changing some of the compositions of lipid nanoparticles using a bio-friendly gallic acid derivative lipid and, in particular, if a gallic acid derivative replaces a certain ratio of an ionizable lipid in a molar composition ratio, it is possible to mitigate toxicity generated by the ionizable lipid, so as to be utilized for drug delivery more safely in vivo.

IPC Classes  ?

• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 9/1271 - Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
• A61K 9/51 - Nanocapsules
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61P 37/04 - Immunostimulants
• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle

Abstract

A respiration-associated coughing evaluation system, a respiration-associated coughing evaluation method, and a wearable device that detect the respiration of the measurement object, obtain a respiratory cycle, classify coughing using voice data of the measurement object, determine respiratory information about the measurement object based on the time at which the measurement object starts coughing during the respiratory cycle through the relationship between the respiratory cycle of the measurement object and the start point of coughing, and transmit the respiratory information.

IPC Classes  ?

• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/087 - Measuring breath flow

Abstract

The present invention relates to a remote surgery system comprising: an augmented reality device that can be used by a surgeon; a virtual reality device that can be used by a collaborating surgeon; and a network and server that enable the augmented reality device and the virtual reality device to communicate with each other. According to the present invention, the remote surgery system can be helpfully used not only for education but also when emergency surgery needs to be performed in a remote area where there is no specialist, such as a military unit. Furthermore, the remote surgery system can be used if a doctor at a local hospital receives support from a doctor at a higher-level hospital when performing surgery or if a doctor in a developing country receives support from a doctor in a developed country.

IPC Classes  ?

• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery

Abstract

The present disclosure relates to a wearable ultrasound system for labor progression monitoring and a labor progression state determination method, wherein a labor progression state, fetal station, and fetal heart rate may be simultaneously identified in real time through wearable ultrasonic transducers in place of medical staff, and in this process, fetal heart signals and cranial signals are obtained through transducers attached to the mother's abdomen and perineum, and different weights for collected information are set according to labor progression information to determine the labor progression state.

IPC Classes  ?

• A61B 8/08 - Clinical applications
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 8/02 - Measuring pulse or heart rate

Abstract

An intraocular lens (IOL) with an adjustable diopter after surgery is disclosed. According to an aspect of the present disclosure, the intraocular lens with an adjustable diopter after surgery may include: a haptic with a cylindrical receptacle, wherein one or more fixtures are configured to extend outwardly on an outer surface of the receptacle; an optic mounted within the receptacle of the haptic, and configured to refract a light, wherein a thread is formed on an inner circumferential surface of the receptacle, and the optic is configured such that an outer circumferential surface thereof engages with the thread and rotates to be able to move forward or backward in a direction in which the light is incident in the receptacle; and one or more magnetic members provided externally in at least one location at a periphery of the optic to rotate the optic by magnetic force.

IPC Classes  ?

• A61F 2/16 - Intraocular lenses

Abstract

The present invention relates to a renal cancer assembloid and a producing method thereof. The renal cancer assembloid according to the present invention is produced by co-culturing RCC, endothelial cells, and fibroblasts to produce an RCC spheroid, and then assembling the RCC spheroid with a renal organoid. It was confirmed that the renal cancer assembloid expresses not only a tumor-related gene but also a renal gene, and thus, the renal cancer assembloid according to the present invention has the effect of simultaneously reproducing a renal tumor and a tumor microenvironment (TME). Therefore, the renal cancer assembloid according to the present invention is expected to be useful for drug screening and biomarker evaluation for renal cancer.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/09 - Tumour cells

Abstract

The present disclosure relates to a preprocessing data construction device and method for training a rehabilitation exercise guide artificial intelligence model, which comprise: acquiring chart data of a patient through an input unit; scanning the chart data; extracting specific data from the scanned chart data; and storing the extracted specific data in a memory on the basis of a predetermined rule, wherein the specific data is used for training the rehabilitation exercise guide artificial intelligence model.

IPC Classes  ?

• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G06F 16/35 - ClusteringClassification
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

An electronic device for determining the suitability of a re-test for each test item, according to one embodiment of the present invention, may comprise a processor, which: acquires, for each test item, original test information and re-test information about patients; uses the original test information and the re-test information on the basis of a criterion for determining whether an error occurs during a test, thereby determining whether an error in the original test has occurred; and identifies a re-test frequency and an error frequency for each test item on the basis of a determined error.

IPC Classes  ?

• G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
• G16H 70/00 - ICT specially adapted for the handling or processing of medical references

Abstract

An embodiment provides a device for measuring the obstruction of a tracheostomy tube, the trachea, and the bronchus, the device comprising an obstruction measurement unit (100) which is coupled to the entrance (11) of a tracheostomy tube where tracheostomy has been performed, and transmits a sound wave and receives a reflected sound wave to measure an obstruction site in any one of the tracheostomy tube (A), the trachea (B), and the bronchus (C).

IPC Classes  ?

• A61B 8/08 - Clinical applications
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

Abstract

The present disclosure relates to a novel thyroid nodule diagnostic biomarker and use thereof, and more specifically to an mRNA biomarker or a combination of mRNA biomarkers that are capable of diagnosing non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) among thyroid nodules with high accuracy and sensitivity compared to benign and malignant tumors. In the present disclosure, it was confirmed that the expression levels of OCLN, ZNF423, LYG1 and AQP5 are associated with the onset or aggravation of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Accordingly, the present disclosure provides OCLN, ZNF423, LYG1 and AQP5 genes as diagnostic biomarkers for non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12Q 1/6851 - Quantitative amplification

Abstract

The present disclosure relates to a composition for preventing or treating graft-versus-host disease (GVHD) containing a TLR5 agonist derived from flagellin as an active ingredient. The TLR5 agonist derived from flagellin according to the present disclosure exhibits an excellent therapeutic effect against GVHD, and thus may be developed as an active ingredient for a composition for the treatment, prevention or alleviation of GVHD.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

Disclosed is a cannula fixing device for insertion into a body including a needle having a specific length, and inserted into the body, a connection part connecting a first tube that supplies a solution to the needle, and the needle, and an expansion part that is selectively expanded from an outer peripheral surface of the needle inserted into the body.

IPC Classes  ?

• A61B 17/34 - TrocarsPuncturing needles

Abstract

Provided are a blood biomarker for diagnosis, prognosis prediction, or treatment of Parkinson's disease (PD), a method for diagnosing or predicting the prognosis of PD using the same, and a method for screening substances for treating PD, where it is confirmed that the levels of 14 types of miRNA are significantly increased or decreased in the blood of PD patients, and the 14 types of miRNA reflect the correlation between genes and environmental factors identified in subjects with PD, thus the 14 types of miRNA are expected to be used as a diagnostic and prognostic biomarker as well as a new therapeutic target related to the pathological mechanism of PD.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]

Abstract

Provided are a submandibular gland tissue biomarker for diagnosis, prognosis prediction, or treatment of Parkinson's disease (PD), a method for diagnosing or predicting the prognosis of PD using the same, and a method for screening substances for treating PD, where it has been confirmed that an SNCAIP gene is significantly decreased and the level of 15 types of miRNA is increased in tissues collected from submandibular gland tissues, and thus PD may be diagnosed using the marker, particularly for subject groups in which the presence or absence of PD cannot be determined by α-synuclein, and since the marker reflects the correlation between genes and environmental factors identified in subjects with PD, the marker can be used as a diagnostic and prognostic biomarker, as well as a new therapeutic target for pathological mechanism of PD.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

An embodiment relates to an astigmatism axis adjustable artificial lens which is adjustable so that a correction axis of the artificial lens matches an astigmatism axis when the astigmatism axis and the correction axis of the artificial lens do not match. Here, the astigmatism axis adjustable artificial lens includes a support part and an optical lens part. The support part is fixed to a lens capsule of a patient's eye. The optical lens part is coupled to the support part and has a correction axis that matches the patient's astigmatism axis. The optical lens part is rotatably coupled to the support part to be adjustable so that the correction axis matches the patient's astigmatism axis.

IPC Classes  ?

• A61F 2/16 - Intraocular lenses

Abstract

A method for providing information, according to one embodiment of the present disclosure, comprises the steps of: generating a diagnosis prediction model in which diagnosis information according to tooth brushing execution or a tooth state is learned; inputting a tooth state image or the execution information of the tooth brushing of an object; generating diagnosis data from the tooth state image or the execution information of the tooth brushing of the object by using the diagnosis prediction model; and displaying the diagnosis data.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• G16H 70/20 - ICT specially adapted for the handling or processing of medical references relating to practices or guidelines
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

An information providing method according to an embodiment of the present disclosure includes the steps of: generating a stress prediction model trained on stress information according to a schedule of a patient; confirming a schedule of a target patient recorded in a mobile device or a wearable device of the target patient; generating diagnostic data for the target patient from the confirmed schedule; and displaying the diagnostic data.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06F 40/205 - Parsing
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• G16H 70/20 - ICT specially adapted for the handling or processing of medical references relating to practices or guidelines

Abstract

According to the present invention, the electronic device including an artificial intelligence (AI) model for detecting free air on the basis of an abdominal CT image may include: at least one processor; and a memory for storing a computer program executed by the at least one processor, wherein the at least one processor is configured to: acquire a CT image of the abdomen for each patient; perform preprocessing on the acquired CT image to identify a free air area; train an artificial intelligence model by using the preprocessed CT image; and predict the presence/absence and area of perforation in the abdomen on the basis of an input CT image by using the trained artificial intelligence model.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
• A61B 6/03 - Computed tomography [CT]
• G06T 7/00 - Image analysis
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture

Abstract

A hybrid shunt system for carotid endarterectomy.

IPC Classes  ?

• A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The present invention relates to messenger RNA (mRNA)-encapsulated double nanoparticles, a method for preparing same, and a pharmaceutical use thereof and, more specifically to: mRNA-encapsulated double nanoparticles comprising a first nanoparticles core in which mRNA, which is an active ingredient, is bonded to an anionic polymer surface or is inserted into the anionic polymer surface, and a second nanoparticle shell in which a biocompatible polymer or a polymer conjugate is formed to surround the outside of the core; a composition for mRNA delivery comprising the double nanoparticles; a composition for a vaccine comprising the double nanoparticles, and the like. The double nanoparticles according to the present invention can be used to safely and efficiently deliver mRNA to a target site.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

Disclosed in the present specification are a composition for improving, enhancing, or restoring the function of pancreatic β cells aged by pregnancy and childbirth, and biomarkers for predicting or diagnosing the function of pancreatic β cells aged by pregnancy and childbirth. In one aspect, the composition of the present invention can effectively enhance the proliferation of pancreatic β cells aged by pregnancy, childbirth, and multiple births by containing dasatinib and quercetin, and the biomarkers of the present invention are used such that conditions caused by pregnancy, childbirth and multiple births, such as an increased cellular stress of pancreatic β cells, impaired cellular respiration and secretory function, or decreased cell proliferation capacity can be predicted or diagnosed.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A method for generating an optic nerve pathway, using matches of MRI images and OCT images, in which low-resolution MRI head images capable of showing the eyeball and optic nerve are matched with corrected OCT eyeball cross-sectional images to model the eyeball and optic nerve pathway in a 3D manner and deformed states of individual eyeballs and optic nerves are identified through the eyeball model and optic nerve model constructed through the 3D modeling, whereby the possibility of myopia and glaucoma can be predicted.

IPC Classes  ?

• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G06T 7/00 - Image analysis

Abstract

The present invention relates to a biomarker panel for the diagnosis or prediction of brain metastasis of lung cancer and a method for the diagnosis or prediction of metastatic brain tumors by using the panel. Accuracy and sensitivity in diagnosing lung cancer brain metastases were improved by providing a biomarker screened from pure tumor cells, beyond the limitations of biomarkers screened on the basis of bulk data of mixed tumor cells and cancer microenvironment cells.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

An embodiment relates to a safety vitreous body cutting device capable of safely removing only a vitreous body attached to a retina without damaging the retina. Here, the safety vitreous body cutting device includes a tubular body part, a cutter part, and a safety net part. The tubular body part is formed in a cylindrical shape, negative pressure is provided at the inside, and an open hole is formed on the outer circumferential surface of a distal end. The cutter part reciprocates along the axial direction of the tubular body part at the inside of the tubular body part to cut the vitreous body introduced into the open hole. The safety net part is provided at the distal end of the tubular body part, and allows the vitreous body to pass through, but prevents the retina tissue from passing through.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery

Abstract

Disclosed is an eyelid speculum including a frame, a first rotary arm coupled to one side of the frame to be rotatable, a second rotary arm coupled to an opposite side of the frame to be rotatable, a movement part configured to move the first rotary arm and the second rotary arm such that the first rotary arm and the second rotary arm are moved in a direction, in which they become closer to or more distant from each other, a first support arm coupled to the first rotary arm to be rotatable, and configured to support an upper eyelid, and a second support arm coupled to the second rotary arm, and configured to support a lower eyelid.

IPC Classes  ?

• A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors

Abstract

The present invention relates to a non-surgical method for inserting an aqueous humor outflow valve, wherein the aqueous humor outflow valve is manufactured using a shape memory polymer that is restored to the original state while reacting at the temperature of the human body, and thus the aqueous humor outflow valve can be inserted into a Tenon's capsule using a syringe without incising ocular tissue.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery
• A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand

Abstract

Disclosed are Alvarez lens-type autofocus glasses and a method for controlling same. Alvarez lens-type autofocus glasses and a method for controlling same, according to an aspect of the present invention, comprise: a frame including mounting portions on which lens groups are mounted; lens groups mounted on the pair of mounting portions, respectively, while multiple lenses overlap each other, the lens groups having a variable focal length; a distance measuring sensor mounted on the frame so as to measure the distance to an object located in front of the frame; and a controller mounted on the frame so as to change the focal length of the lens groups in accordance with the distance to the object measured by the distance measuring sensor. The lens groups may comprise: a first lens having a curved surface configured such that one of a first surface that faces the outside and a second surface that faces the eyes forms a first parabola, and the first lens having a curved surface having a continuous curved surface formed to form a second parabola which is symmetric to the first parabola; and a second lens formed such that one of a first surface that faces the outside and a second surface that faces the eyes has a curved surface which is symmetric to the first lens, the second lens being disposed to overlap the first lens such that same can move perpendicularly to an optical axis with regard to the first lens, the focal length of the second lens being varied by movements thereof.

IPC Classes  ?

• G02C 7/08 - Auxiliary lensesArrangements for varying focal length
• G02C 11/00 - Non-optical adjunctsAttachment thereof

Abstract

A liquid lens-type auto-focus glasses and a control method thereof are disclosed. The liquid lens-type auto-focus glasses according to one aspect of the present invention comprise: a frame including a pair of rims that form mounting parts on which lens groups are mounted, a bridge that connects the pair of rims, and a pair of temples that extend from both sides of the rims toward the ears of the human body so as to support the rims to the head part of the human body; the lens groups, each mounted on the pair of mounting parts in a state in which the plurality of lenses are overlapped, one of the overlapped lenses being a liquid lens having a variable focal length; a distance measurement sensor which is mounted on the frame and which measures the distance to an object positioned in front of the frame; and a control unit for changing the focal length of the liquid lens according to the distance to the object, measured by the distance measurement sensor.

IPC Classes  ?

• G02C 7/08 - Auxiliary lensesArrangements for varying focal length
• G02C 11/00 - Non-optical adjunctsAttachment thereof

Abstract

This method for providing a video for myopia prevention comprises the steps in which: a video processing device receives a source video; the video processing device determines a non-focal region, other than a focal region, in a specific frame of the source video; and the video processing device adjusts focus for the non-focal region. The video processing device adjusts the focus so that the focal region corresponds to emmetropia and the non-focal region corresponds to at a certain level of myopic defocus.

IPC Classes  ?

• H04N 21/4728 - End-user interface for requesting content, additional data or servicesEnd-user interface for interacting with content, e.g. for content reservation or setting reminders, for requesting event notification or for manipulating displayed content for selecting a ROI [Region Of Interest], e.g. for requesting a higher resolution version of a selected region
• A61H 5/00 - Exercisers for the eyes

Abstract

The present invention relates to a brain-metastatic lung cancer cell line and a use of Noggin as a marker for brain metastasis of lung cancer. In the present invention, a brain metastatic lung cancer cell line with optimized characteristics for brain metastasis was established by repeatedly transplanting the lung cancer cell line through the carotid artery. In addition, in the brain metastatic lung cancer cell line, the expressions of Noggin protein and its mRNA are reduced, confirming that the motility and invasiveness of cells are reduced and adhesion increased. Therefore, the Noggin protein or its gene is expected to be useful as a biomarker for diagnosis of brain metastasis of lung cancer and its target therapy.

IPC Classes  ?

• A01K 67/0271 - Chimeric vertebrates, e.g. comprising exogenous cells
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present disclosure relates to an organoid selection device and method, and, particularly, can provide an organoid selection device and method, which enable a mature organoid to be selected from an image by using an artificial intelligence model. Particularly, provided is a device, which constructs and verifies an artificial intelligence model so as to use only image information about an organoid, and thus can more accurately select a mature organoid exhibiting uniform efficacy.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation

Abstract

Disclosed are an artificial intelligence-based server for managing patients by underlying disease using medical records, and a method therefor. A patient management server, according to one embodiment of the present invention, comprises: a memory; and a processor for managing information of a patient on the basis of initial data of the patient, wherein the processor: collects the initial data including medical records and performs pre-processing on the initial data, the pre-processing being performed according to pre-processing criteria including text processing and text data vectorization on the initial data; performs training processing by inputting the pre-processed initial data into a pre-trained artificial intelligence model so as to obtain at least one of classification by underlying disease for the patient, precautions for medical treatment, and whether or not an interdepartmental consultation is necessary; and provides training processing results including the at least one of classification by underlying disease for the patient, precautions for medical treatment, and whether or not an interdepartmental consultation is necessary.

IPC Classes  ?

• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 70/20 - ICT specially adapted for the handling or processing of medical references relating to practices or guidelines
• G06F 18/10 - Pre-processingData cleansing
• G06F 18/241 - Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
• G06F 40/279 - Recognition of textual entities
• G06F 40/268 - Morphological analysis

Abstract

The present invention relates to a tear film breakup detection method, which may comprise the steps of: collecting an eye image of a user; filtering the eye image of the user so as to generate a preprocessed image; classifying, through a preset model, a frame in which at least one tear film of the user breaks up in the preprocessed image; determining a tear film breakup area in the frame in which the tear film breaks up, and classifying a tear film breakup form; and determining, as a tear film breakup time, the time difference between the frame in which the user first blinks and the frame in which the tear film of the user breaks up.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• A61B 3/14 - Arrangements specially adapted for eye photography
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS

Abstract

The present invention relates to a method of manufacturing an alveolar organoid using alveolar cell-derived induced pluripotent stem cells. The alveolar organoid manufactured according to the present invention is differentiated from the human alveolar cell-derived induced pluripotent stem cells, and thus induced pluripotent stem cells may efficiently differentiate into alveolar organoids due to the epigenetic memory of alveolar cells. Therefore, the alveolar organoids are expected to be effectively used for research on the pathological process of respiratory diseases, screening for finding therapeutic drugs, and the like.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present invention relates to a method for determining the risk of developing high-risk open-angle glaucoma specific to Koreans by polygenic risk score analysis and, in particular, to: a method for determining single nucleotide polymorphism (SNP) from a biological sample; a biomarker composition for determining open-angle glaucoma in Koreans, comprising SNP; a composition for predicting the risk of developing open-angle glaucoma, comprising an agent for detecting the biomarker composition; and a kit for predicting the risk of developing open-angle glaucoma, comprising the composition. According to the present invention, it is possible to provide information useful in predicting the risk of developing open-angle glaucoma in Koreans on the basis of polygenic risk scores. In particular, such information can be more readily provided by using the kit of the present invention.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present invention relates to a tubular scaffold and a method of manufacturing the same. The tubular scaffold has physical properties matching the characteristics of a tubular organ that bends or rotates when a double layer is formed by electrospinning nanofibers, and not only has excellent cell adhesion ability but may also maintain cell functions. Also, since such effects have been proven in an animal model, the tubular scaffold may be mass-produced and used as a highly functional tubular organ having various sizes and lengths.

IPC Classes  ?

• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
• A61F 2/06 - Blood vessels
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/38 - Animal cells
• D01D 5/00 - Formation of filaments, threads, or the like

Abstract

The present invention relates to self-assembled nanoparticles comprising a novel choline-poly(ε-caprolactone) conjugate, in which, by using the specific interaction between choline and choline transporters, chemically modifying the surface of nanoparticles with choline to temporarily prevent choline transporters from transporting choline into cells, and self-assembling an amphiphilic conjugate consisting of hydrophilic choline and hydrophobic poly(ε-caprolactone) in an aqueous phase, nanostructures are prepared, and choline modified on the surface of the nanoparticles is specifically bound to choline transporters of cancer cells, wherein this binding reduces the intracellular uptake of choline by choline transporters, which may result in delayed or suppressed cancer cell growth and lead to cancer cell death.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61P 35/00 - Antineoplastic agents
• C08G 63/91 - Polymers modified by chemical after-treatment
• C08G 63/08 - Lactones or lactides
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

According to one embodiment of the present disclosure, disclosed is a server for providing a model for predicting mortality and long-term occupancy of a post-surgery patient and an operation method thereof. The server comprises at least one processor for executing at least one instruction stored in a memory, wherein the at least one processor can obtain patient-related information including at least one of clinical information, surgery information, or blood test results of a patient, apply the obtained patient-related information to an artificial intelligence learning model for predicting mortality and long-term occupancy of a patient, and generate, using an ensemble learning model, result predicting at least one of mortality or long-term occupancy of the patient.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G06N 20/20 - Ensemble learning

Abstract

The present invention relates to a method for determining the risk of developing normal tension glaucoma specific to Koreans by using apolipoprotein E gene polymorphism analysis and, more specifically, to: a method for determining single nucleotide polymorphism (SNP) from a biological sample; a biomarker composition comprising single nucleotide polymorphisms (SNPs) for determining normal tension glaucoma of Koreans; a composition comprising an agent capable of detecting the biomarker composition for predicting the risk of developing normal tension glaucoma; and a kit comprising the composition for predicting the risk of normal tension glaucoma. According to the present invention, information useful for predicting the risk of normal tension glaucoma in Koreans can be provided on the basis of apolipoprotein E gene polymorphism analysis. In particular, this information can be more easily provided using the kit of the present invention.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The method comprises obtaining a document including a target infectious disease as a corpus for each of a plurality of time sections, converting a plurality of words included in the obtained corpus into embedding vectors, calculating similarities between the respective converted embedding vectors and an embedding vector indicating the target infectious disease, extracting an embedding vector of which the calculated similarity is higher than a predetermined first threshold value, for each time section, obtaining first time series data indicating a search volume, over time, of a word corresponding to the embedding vector extracted for each time section, calculating a correlation coefficient between the obtained first time series data and second time series data, and generating a word corresponding to the first time series data of which the calculated correlation coefficient is higher than a predetermined second threshold value as a keyword for each time section.

IPC Classes  ?

• G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
• G06N 20/00 - Machine learning

Abstract

A central monitoring system using artificial ventilators, comprises: a plurality of artificial ventilators positioned inside a hospital room in a ward and connected to the respiratory tracts of a plurality of patients recovering inside the hospital room, so as to supply oxygen to the plurality of patients; an image-capturing unit positioned inside the hospital room so as to capture the plurality of patients in real time; a communication unit for receiving a plurality of pieces of patient condition information transmitted from the plurality of artificial ventilators and patient-capturing information transmitted from the image-capturing unit; and a communication connection unit for connecting the plurality of artificial ventilators and the communication unit, and transmitting, to the communication unit, the plurality of pieces of patient condition information transmitted from the plurality of artificial ventilators.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Abstract

The present invention relates to a composition capable of preventing inflammatory diseases caused by radiation therapy, or use thereof. Tranilast of the present invention can reduce rectal wall infiltration of mast cells and provide an anti-inflammatory effect against radiation-induced colitis, and thus radiation-induced inflammatory diseases can be effectively prevented when the tranilast of the present invention is pre-administered to patients in which radiation-induced inflammatory diseases have not yet occurred, such as patients receiving pelvic radiation therapy.

IPC Classes  ?

• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 39/00 - General protective or antinoxious agents
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present disclosure relates to an artificial intelligence-based device and method for providing guide information about rehabilitation exercise. The device comprises: a communication module for communication with an external device; a storage module for storing at least one process for providing guide information about rehabilitation exercise on the basis of artificial intelligence; and a control module for performing, on the basis of the at least one process, an operation for providing the guide information about rehabilitation exercise on the basis of artificial intelligence. The control module: collects medical data and a medical image, captured prior to surgery, of a corresponding patient on the basis of the storage module and a separate database; pre-processes the medical image and then inputs the pre-processed medical image to a first pre-trained model based on artificial intelligence to predict the probability that post-surgical complications will occur; and generates prediction information on the basis of the predicted result and provides the prediction information to a medical staff terminal.

IPC Classes  ?

• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• A63B 24/00 - Electric or electronic controls for exercising apparatus of groups
• G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition

Abstract

The present disclosure relates to a method, device, and system for automatically triaging and controlling a response. The method comprises the steps of: acquiring vitals information about a patient in question; extracting data for each item in the acquired vitals information about the patient; mapping the extracted data for each item to the corresponding item; calculating a severity response score corresponding to the risk level of the patient on the basis of the data for each item mapped to the corresponding item; setting a severity response scale based on the severity response score corresponding to the calculated risk level of the patient; and controlling so that the set severity response scale information is transmitted to at least one terminal and output.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 70/00 - ICT specially adapted for the handling or processing of medical references
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

Abstract

The present invention provides a system for interpolating an object by generating a viewpoint-transformed image, comprising: an image preparation unit that prepares a target viewpoint image and an auxiliary viewpoint image obtained by photographing the same object from different viewpoints; a viewpoint transformation unit that generates a viewpoint-transformed image by transforming the auxiliary viewpoint image to a viewpoint of the target viewpoint image; and an image matching unit that matches the target viewpoint image and the viewpoint-transformed image and interpolates the target viewpoint image by using the viewpoint-transformed image.

IPC Classes  ?

• G06T 3/4007 - Scaling of whole images or parts thereof, e.g. expanding or contracting based on interpolation, e.g. bilinear interpolation
• G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods

Abstract

[Method for reprogramming type 1 alveolar cells into type 2 alveolar cells using Rhosin] The present invention relates to a composition for inducing the reprogramming of type 1 alveolar cells into type 2 alveolar cells, the composition containing Rhosin as an active ingredient. According to the present invention, it is expected to be possible not only to reprogram AT1 cells into AT2 cells using Rhosin and thereby efficiently obtain AT2 cells which were previously difficult to obtain in sufficient numbers, but also to reprogram AT1 cells into AT2 cells in organoids while culturing the organoids themselves rather than culturing single cells, and thereby obtain cells having physiological activity more similar to that of actual tissue. [Method for reprogramming type 1 alveolar cells into type 2 alveolar cells using Dasatinib] The present invention relates to a composition for inducing the reprogramming of type 1 alveolar cells into type 2 alveolar cells, the composition containing Dasatinib as an active ingredient. According to the present invention, it is expected to be possible not only to reprogram AT1 cells into AT2 cells using Dasatinib and thereby efficiently obtain AT2 cells which were previously difficult to obtain in sufficient numbers, but also to reprogram AT1 cells into AT2 cells in organoids while culturing the organoids themselves rather than culturing single cells, and thereby obtain cells having physiological activity more similar to that of actual tissue. [Method for reprogramming type 1 alveolar cells into type 2 alveolar cells using ML141] The present invention relates to a composition for inducing the reprogramming of type 1 alveolar cells into type 2 alveolar cells, the composition containing ML141 as an active ingredient. According to the present invention, it is expected to be possible not only to reprogram AT1 cells into AT2 cells using ML141 and thereby efficiently obtain AT2 cells which were previously difficult to obtain in sufficient numbers, but also to reprogram AT1 cells into AT2 cells in organoids while culturing the organoids themselves rather than culturing single cells, and thereby obtain cells having physiological activity more similar to that of actual tissue. [ML141-containing composition for inhibiting lung cancer metastasis] The present invention relates to a composition for inhibiting lung cancer metastasis, the composition containing ML141 as an active ingredient. [Dasatinib-containing composition for inhibiting lung cancer metastasis] The present invention relates to a composition for inhibiting lung cancer metastasis, the composition containing Dasatinib as an active ingredient.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 35/00 - Antineoplastic agents
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 31/415 - 1,2-Diazoles
• A61P 35/04 - Antineoplastic agents specific for metastasis
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present disclosure relates to an apparatus for providing augmented reality-based rehabilitation training, comprising: a communication unit that communicates with a terminal and a virtual reality apparatus; a storage unit storing one or more instructions for providing augmented reality-based rehabilitation training; and a processor that performs operations according to the instructions, wherein the processor may select a first target motion for rehabilitation training of a user on the basis of a rehabilitation part of the user, state information about the rehabilitation part, and a rehabilitation training schedule of the user, output, by means of the virtual reality apparatus, an image representing the selected first target motion, receive, by means of the communication unit, an image captured by the terminal, recognize, in the received image, a performance motion of the user following the first target motion, and evaluate the recognized performance motion.

IPC Classes  ?

• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06V 40/20 - Movements or behaviour, e.g. gesture recognition
• G06V 10/12 - Details of acquisition arrangementsConstructional details thereof
• G06V 20/64 - Three-dimensional objects
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects

Abstract

The present disclosure relates to a device and a method for automatically adjusting a paraffin block position of a tissue slicing device, the device including: a body unit; a block fixing unit for fixing a paraffin block and movably and rotatably installed with respect to the body unit; a cutting unit which is arranged on the lower side of the fixing unit in the body unit and on which a blade for cutting the paraffin block is mounted; an information acquisition unit for acquiring first information on the paraffin block fixed to the block fixing unit; and a processor for acquiring second information on a tissue within the paraffin block on the basis of the first information, determining a position and an angle for cutting the paraffin block on the basis of the second information, and controlling the operation of the block fixing unit on the basis of the determined position and angle.

IPC Classes  ?

• G01N 1/36 - Embedding or analogous mounting of samples
• G01N 1/28 - Preparing specimens for investigation
• G06V 10/10 - Image acquisition
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G06N 3/08 - Learning methods

Abstract

According to the present disclosure, an electronic device for preventing myopia by adjusting a display wavelength range according to time may comprise a camera, a display unit, and a processor electrically connected to the camera and the display unit so as to control operations, wherein the processor is configured to: identify a wavelength range for at least a part of the display unit; sense information related to an external environment of the electronic device via the camera; and on the basis of the information related to the external environment, control the wavelength range for the at least a part of the display unit so as to adjust a wavelength range provided to a user of the electronic device via the at least a part of the display unit.

IPC Classes  ?

• G09G 3/32 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED]
• G09G 5/10 - Intensity circuits
• G09G 3/20 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix

Abstract

The present invention relates to an immunomodulatory therapeutic composition for immunomodulation through the transplantation of induced pluripotent stem cell (iPSC)-derived mitochondria. The iPSC-derived mitochondria according to the present invention overexpress UCP2, and the expression of UCP2 was found to be associated with an immunomodulatory effect. In addition, the administration of iPSC-derived mitochondria was found to enhance mitochondrial function and thereby increase ATP synthesis and mitochondrial membrane potential. In addition, the present invention was found to regulate the expression of autoimmune disease-related immune cells and to increase the synergistic effect of immune cell regulation when used in combination with metformin. In addition, the present invention was found to reduce the activity of autoimmune disease symptoms and inhibit cell expression related to autoimmunity. In addition, treating peripheral blood mononuclear cells with iPSC-derived mitochondria was found to inhibit Th17 expression and increase Treg expression, as well as improve immunomodulation and ameliorate the pathological activity of various immune diseases.

IPC Classes  ?

• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• A61P 37/00 - Drugs for immunological or allergic disorders
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

A method for distinguishing between types of thyrotoxicosis including Graves' disease, autoimmune thyroiditis, and subacute thyroiditis on the basis of machine learning according to an embodiment of the present invention comprises the steps of: acquiring a basic ultrasound image (gray scale), a color Doppler image, and a power Doppler image of the thyroid of a diagnosis subject; and determining whether the diagnosis subject corresponds to one of Graves' disease, autoimmune thyroiditis, or subacute thyroiditis by using a machine-learning model trained to distinguish between types of thyrotoxicosis on the basis of basic ultrasound images, color Doppler images, and power Doppler images of the thyroids of each of Graves' disease, autoimmune thyroiditis, and subacute thyroiditis patients.

IPC Classes  ?

• A61B 8/08 - Clinical applications
• A61B 8/06 - Measuring blood flow
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G06N 20/00 - Machine learning

Abstract

The present invention relates to a crutch for fixing to a shoulder, the crutch comprising: a main body that supports a user's shoulder and assists the user in walking according to manipulations by the user; a fixing strap that is provided on the main body and worn around the circumference of the user's shoulder; a cut portion cut into a region of the fixing strap; and a detachment portion that detachably couples one side and the other side of the fixing strap adjacent to the cut portion.

IPC Classes  ?

• A61H 3/02 - Crutches
• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
• A44B 11/00 - BucklesSimilar fasteners for interconnecting straps or the like, e.g. for safety belts

Abstract

An embodiment provides a method for measuring a femoral anterior angle and a tibial torsion angle by using artificial intelligence, the method comprising the steps of: (a) obtaining, by a CT scanner, 2D CT images of the femur, the tibia, and the malleolus of a patient; (b) storing, in a big-data unit, the 2D CT images transmitted from the CT scanner; (c) setting, by an artificial intelligence unit, a first baseline related to the femoral head and neck, a second baseline related to the lower femoral, a third baseline related to the upper tibial, and a fourth baseline related to the malleolus, on the basis of the 2D CT images; and (d) measuring, by an angle measurement unit, a femoral anterior angle formed between the first baseline and the second baseline, and a tibial torsion angle formed between the third baseline and the fourth baseline.

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]
• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications

Abstract

An apparatus and a method for predicting re-rupture of a tendon based an artificial intelligence (AI) are provided. The apparatus includes a communication module to make communication with an external device, an acquiring module to acquire at least one arthroscopic image including a surgical portion of a patient experiencing a surgery, a storage module to store at least one process based on the AI, and a control module to perform an operation for predicting the re-rupture of the tendon based on the AI, through the at least one process. The control module performs a pre-processing operation for the at least one arthroscopic image, predicts a probability of the re-rupture of the tendon by inputting the at least one arthroscopic image, which is pre-processed, into a pre-trained model based on the AI, and generates prediction information for the patient based on a prediction result.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06T 7/00 - Image analysis

Abstract

According to an embodiment of the present disclosure, disclosed are an eye drop storage device for assisting a user to use an eye drop and a method for operating the eye drop storage device. The eye drop storage device may comprise: a body; an eye drop support unit connected to the body and accommodating an eye drop container; a detection sensor connected to the body and obtaining a user input for opening or closing a lid of the eye drop container; an eye drop opening and closing unit connected to the body; and at least one processor, wherein at least one processor opens or closes the lid of the eye drop container on the basis of the user input through the eye drop opening and closing unit.

IPC Classes  ?

• A61J 1/16 - Holders for containers
• A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
• A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes DetailsAccessories therefor
• A61J 1/18 - Arrangements for indicating condition of container contents, e.g. sterile condition
• A61J 7/04 - Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
• A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
• G16H 20/13 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers

Abstract

An electronic device to which a machine learning ensemble model is applicable, according to an exemplary embodiment of the present disclosure, may comprise: a first model neural-network-trained on the basis of training images; a second model trained on the basis of training test data; a third model using voting based on a plurality of statistical methodologies so as to output the infection probability of malaria infection; and a processor, which inputs, into the first model, a blood image to be tested, uses the first model to make a primary determination of malaria infection about the blood image, inputs, into the second model, blood data to be tested, uses the second model to make a secondary determination of malaria infection about the blood data, and uses the third model to output the malaria infection probability.

IPC Classes  ?

• G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06N 20/20 - Ensemble learning
• G06T 7/00 - Image analysis
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to a polynomial curve design technology and, more specifically, to an apparatus and a method for designing a polynomial curve by using a hodograph control polygon. According to an embodiment of the present invention, even when the order of the polynomial curve increases, the shape of the curve can be easily predicted. In addition, the shape of the curve can be adjusted by moving the position of a control point, and simultaneously, a tangent vector at a specific point on the curve can be controlled through each side of the hodograph control polygon, whereby the shape of the polynomial curve can be easily adjusted. Since the sum of the lengths of respective sides of the hodograph control polygon corresponds to a numerical integral of a speed function of the polynomial curve, the hodograph control polygon and the curve have similar lengths, and thus the shape and length can be simultaneously controlled when the polynomial curve is designed.

IPC Classes  ?

• G06T 11/20 - Drawing from basic elements, e.g. lines or circles
• G06T 17/30 - Surface description, e.g. polynomial surface description

Abstract

A processing method using a surgical guide, in relation to an example of the present invention, may comprise: a first step of obtaining at least one medical image among a CT image and an MRI image; a second step of pre-processing the at least one medical image and segmenting same into the humerus head of the humerus and other structures; a third step of generating a three-dimensional (3D) digital structure model for a shoulder joint of a patient by using the segmented image; a fourth step of establishing, on the basis of the digital structure model, a virtual plan for determining a resection surface for the humeral head; a fifth step of generating, on the basis of information about the resection surface determined in the virtual plan, design information for manufacturing the surgical guide; and a sixth step of generating the surgical guide by means of 3D printing technology using the design information.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• G06T 17/00 - 3D modelling for computer graphics
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The method for generating a deep learning-based surgery plan, related to an embodiment of the present invention may include: a first step of acquiring X-ray image information; a second step of performing preprocessing for analysis of a predetermined region of the X-ray image information; a third step of analyzing the preprocessed X-ray image by using a convolutional neural network and extracting feature information from the result of the analysis and learning same; a fourth step of repeating the first step to the third step and generating template data for the predetermined region, on the basis of the repeatedly learned feature information; a fifth step of obtaining first X-ray image information of a user; a sixth step of extracting first feature information related to the user from the feature information by using the first X-ray image information and the template data; and a seventh step of generating a surgery plan related to the user, on the basis of the first feature information.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

The present invention relates to an eyelid speculum comprising: a frame; a first rotary arm rotatably coupled to one side of the frame; a second rotary arm rotatably coupled to the other side of the frame; a moving part for moving the first rotary arm and the second rotary arm in the direction of moving closer to each other or in the direction of moving away from each other; a first support arm rotatably coupled to the first rotary arm so as to support the upper eyelid; and a second support arm rotatably coupled to the second rotary arm so as to support the lower eyelid.

IPC Classes  ?

• A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors

Abstract

The present disclosure relates to a fomentation assistance apparatus comprising: a communication module that receives affected part data from a user terminal; a memory storing the affected part data; a fomentation module that performs a fomentation assistance operation including a cold fomentation operation and a hot fomentation operation; and a control module that controls the fomentation assistance operation on the basis of the affected part data, wherein the affected part data may include at least one of the time of injury, the type of affected part, and the degree of injury.

IPC Classes  ?

• A61F 7/02 - Compresses or poultices for effecting heating or cooling
• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body

Abstract

Provided is an immunomodulatory treatment composition for a transplantation disease through combined administration of a microbiome and an immunosuppressant. According to the present disclosure, it was confirmed that in an allogeneic transplantation cell model, combined administration of FK506 and the microbiome suppressed alloresponse and regulated the activity of T cells and B cells. Further, it was confirmed that in an acute graft-versus-host disease animal model, the combined administration reduced the disease activity, increased the probability of survival, and protected the tissue damage. In addition, it was confirmed that the combined administration improved transplantation rejection diseases by reducing the activity of Th1 and Th17 and increasing the activity of Tregs, and thus can be usefully used as an immunomodulator for transplantation rejection.

IPC Classes  ?

• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61P 37/04 - Immunostimulants

Abstract

The present invention relates to a chair having safety belts, the chair comprising: a chair body having a seat plate, on which an occupant sits, and a backrest, which is coupled to the seat plate and supports the back of the occupant; and safety belts which are detachably connected to the backrest and worn on the upper body of the occupant, wherein the safety belts generate elastic force that presses the upper body of the occupant against the backrest and extends the waist of the occupant.

IPC Classes  ?

• A47C 7/62 - Accessories for chairs
• A47C 7/40 - Supports for the head or the back for the back
• A44B 11/00 - BucklesSimilar fasteners for interconnecting straps or the like, e.g. for safety belts

Abstract

The present invention relates to a chair having an abdominal support band function, the chair comprising: a chair body including a seat on which a sitter is seated and a backrest which is coupled to the seat and supports the back of the sitter; and a wearing part which is detachably coupled to the backrest, is worn on the upper body of the sitter, and generates an elastic force for bringing the upper body of the sitter into close contact with the backrest to cause the sitter to straighten himself/herself.

IPC Classes  ?

• A47C 7/46 - Supports for the head or the back for the back with special, e.g. adjustable, profile"Ackerblom" profile chairs
• A47C 31/02 - Upholstery attaching means

Abstract

A device and method for predicting a pathologic fracture in the proximal femur are disclosed. The device for predicting a pathologic fracture in the proximal femur according to an aspect of the present invention is a device for predicting a pathologic fracture in the proximal femur of an advanced cancer patient, including: a memory for storing one or more instructions; and a processor for executing the one or more instructions, wherein the processor can process a CT image including the femur of the cancer patient to generate an input image by executing the one or more instructions, input the input image into a fracture prediction artificial neural network model, and obtain prediction information about whether a pathologic fracture in the proximal femur will occur within a predetermined period from the time of acquiring the CT image which is output by the fracture prediction artificial neural network model.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06T 7/00 - Image analysis
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating autosomal dominant polycystic kidney diseases. When the cetirizine and L-5-hydroxytryptophan according to the present invention are administered alone or in combination, cyst formation is inhibited in an autosomal dominant polycystic kidney disease model induced by PKD1 or PKD2 gene mutation. Therefore, the cetirizine or L-5-hydroxytryptophan according to the present invention is expected to be advantageously used as a therapeutic agent for autosomal dominant polycystic kidney diseases.

IPC Classes  ?

• A61K 31/4965 - Non-condensed pyrazines
• A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A device for inserting a chest tube for thoracoscopy comprises a photographing module that photographs an inside of a subject's body and transmits a photographed in-vivo image to an outside; a chest tube that is formed in a rigid tube shape and in which the photographing module is inserted and installed; a guide part that is coupled to the photographing module and guides the photographing module into the chest tube; a handle module that is coupled to the guide part and moves the guide part and photographing module; and a mobile device that receives data from the photographing module, and searches for and reproduces the in-vivo image photographed by the photographing module in real time.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
• A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems

Abstract

Provided according to the present invention is a viewing distance measurement apparatus using an infrared distance measurement sensor, the viewing distance measurement apparatus comprising: a main body having a front frame and a pair of side frames connected to both sides of the front frame; a gaze tracking unit that is coupled to the center of the front frame and tracks the gaze of a user to generate gaze tracking information; a distance measurement unit that is located adjacent to the gaze tracking unit and generates distance measurement information with respect to a subject being watched by the user; a data management unit that is coupled to the bottom of one side frame of the pair of side frames, receives the gaze tracking information from the gaze tracking unit, and receives the distance measurement information from the distance measurement unit; and a battery unit coupled to the bottom of the other side frame of the pair of side frames.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
• A61B 3/14 - Arrangements specially adapted for eye photography
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes

Abstract

Disclosed are a smart eye patch utilizing the Internet of Things, and a method and a system for controlling the operation thereof. A terminal communicating with a smart eye patch including at least one light-emitting unit and sensor according to the present disclosure may comprise: a communication module; a display; a reception unit for receiving a signal from the smart eye patch; an analysis unit for processing and analyzing the received signal from the smart eye patch; and a control unit for controlling the operation of the smart eye patch according to the content analyzed by the analysis unit.

IPC Classes  ?

• A61F 9/04 - Eye-masks
• G16Y 40/10 - DetectionMonitoring
• G16Y 10/60 - HealthcareWelfare
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

A device and method for extracting a plurality of tile images from specimen cytology slide images divided according to a cell staining method, and classifying a class of at least one of a type of cancer and whether there is cancer according to a cell staining method in any specimen cytology slide image using a prediction model that has undergone annotation-based learning on the specimen cytology slide images or the tile images.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• B01L 9/00 - Supporting devicesHolding devices
• G01N 1/30 - StainingImpregnating
• G01N 1/31 - Apparatus therefor
• G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
• G16B 40/20 - Supervised data analysis

Abstract

The present invention relates to a method for predicting survival of non-small cell lung cancer patients with brain metastasis. More specifically, it proposes a method that is useful for predicting the survival of the patients by comparing TMTrg of the patients with cut off value for predicting long term survival.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

The present disclosure relates to a virtual autopsy detection device and method, which may: receive a two-dimensional image; preprocess the received two-dimensional image; learn the preprocessed two-dimensional image; generate a three-dimensional image and result data on the basis of the learned two-dimensional image; divide the generated three-dimensional image into a plurality of three-dimensional images; and display the plurality of divided three-dimensional images and the result data.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 16/00 - Devices specially adapted for vivisection or autopsy
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS

Abstract

The present invention relates to a method of developing a tissue-specific vascular endothelial cell line based on iPSCs derived from human tissue-specific cells. When an organoid is manufactured using the cell line based on the iPSCs derived from human tissue-specific cells, the organoid manufacturing period may be significantly shortened, thereby solving the problem of sustainability, which is a major drawback known in the related art, and may be stored conveniently, and thus may be easily used during each experiment, thereby greatly increasing efficiency. Also, the organoid manufactured from the cell line of the present invention may be usefully used in the manufacture of blood vessel organoids in that the organoid is not only tissue-specific but also exhibits an excellent level of morphological and functional maturity.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present disclosure relates to a braille recognition band, and an operation method and system therefor. The method includes the steps of: confirming whether a braille recognition band is activated; outputting an alarm signal when the braille recognition band is activated; transmitting a first signal to a terminal; obtaining braille sensing data; and transmitting a second signal to the terminal.

IPC Classes  ?

• G09B 21/00 - Teaching, or communicating with, the blind, deaf or mute
• G06F 1/16 - Constructional details or arrangements
• G06F 3/16 - Sound inputSound output
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06V 30/142 - Image acquisition using hand-held instrumentsConstructional details of the instruments
• G06V 30/41 - Analysis of document content
• G10L 13/08 - Text analysis or generation of parameters for speech synthesis out of text, e.g. grapheme to phoneme translation, prosody generation or stress or intonation determination
• G10L 15/26 - Speech to text systems

Abstract

The present invention relates to a composition for diagnosing limb-girdle muscular dystrophy type 2H, a method of providing information for diagnosis, and a method of screening a drug for the treatment of limb-girdle muscular dystrophy type 2H.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a method for analyzing the risk of developing normal tension glaucoma in Koreans by a single nucleotide polymorphism (SNP) and, more specifically, relates to: a method for identifying, from a biological sample, one or more SNPs selected from the group consisting of rs10483727 and rs33912345; a biomarker composition for detecting normal tension glaucoma in Koreans, comprising an SNP; a composition for predicting the risk of developing normal tension glaucoma, comprising an agent capable of detecting the biomarker composition; and a kit for predicting the risk of developing normal tension glaucoma, comprising the composition. According to the present invention, it is possible to provide information useful for predicting the risk of developing normal tension glaucoma in Koreans on the basis of SNPs. In particular, such information can be more conveniently provided by using the kit of the present invention.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism

Abstract

Embodiments of the present disclosure relate to a tray device for a closed mouth impression for obtaining horizontal/vertical intermaxillary relations, which can significantly reduce the number of patient visits and a denture fabrication schedule by accurately recording the oral environment of a patient with a single impression. The tray device for a closed mouth impression for obtaining horizontal/vertical intermaxillary relations, according to the present embodiments, comprises one or both of an upper jaw tray and a lower jaw tray, wherein the upper jaw tray has support members that protrude by a predetermined height from the anterior teeth portion and the posterior teeth portions at either side, the lower jaw tray has support members that protrude by a predetermined height from the anterior teeth portion and the posterior teeth portions at either side, and both the upper jaw tray and the lower jaw tray are provided with a plurality of capping members that can be coupled to the support members formed at the three locations.

IPC Classes  ?

• A61C 9/00 - Impression methods specially adapted for dental prostheticsImpression cups therefor
• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereonDental implantsImplanting tools

Abstract

The present invention relates to a device for fixing a microscope slide, the device comprising: a base that can be detachably coupled to a stage on which the slide is disposed; a support unit which is connected to one side of the base and supports one side of the slide; a rotation unit which is rotatably coupled to the other side of the base and is rotated toward the support unit to press and fix the other side of the slide; and a first protection unit which is provided in the rotation unit and reduces the friction between the rotation unit and the other side of the slide.

IPC Classes  ?

• G02B 21/26 - StagesAdjusting means therefor
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G02B 21/34 - Microscope slides, e.g. mounting specimens on microscope slides

Abstract

The method for performing endoscopic examination according to an exemplary embodiment of the present invention may include the steps of obtaining an endoscopic image and a 3D model of a target organ; identifying location information of an endoscope on the 3D model in real time based on simultaneous localization and mapping (SLAM); classifying a plurality of areas constituting the 3D model into examination areas and unexamined areas by using the endoscopic image and the location information; and providing feedback information based on the examination areas and unexamined areas.

IPC Classes  ?

• G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
• G06T 7/579 - Depth or shape recovery from multiple images from motion
• G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects

Abstract

A brain protection pad is disclosed. A brain protection pad, according to one embodiment of the present invention, comprises an artificial dura mater layer configured to cover the brain exposed to the outside after a craniotomy. The artificial dura mater layer comprises artificial dura mater having a predetermined area so as to cover the brain, and may comprise one or more from among incision portions formed by partially incising the artificial dura mater so as to enable the artificial dura mater to expand in a direction perpendicular to the incision direction, and corrugations formed by folding the artificial dura mater so as to enable the artificial dura mater to expand in an unfolding direction.

IPC Classes  ?

• A61F 13/12 - Bandages or dressingsAbsorbent pads specially adapted for the head or neck

Abstract

The present invention relates to an auxiliary device worn in the oral cavity and includes: a first wearing part formed so as to be bitten by the teeth on either the left or right side; and a swallowing prevention part bent and extending from the front end portion and located on the palate side when the auxiliary device is worn. Accordingly, the auxiliary device prevents swallowing accidents during dental treatments, thus ensuring the safety of patients, and supports the use of suction equipment and can thus assist a doctor in treatment.

IPC Classes  ?

• A61C 19/00 - Dental auxiliary appliances
• A61C 5/80 - Dental aids fixed to teeth during treatment, e.g. tooth clamps
• A61C 17/02 - Rinsing or air-blowing devices, e.g. using fluid jets

Abstract

The present invention provides an oral scanner cover comprising: a body part, coupled to the portion of the tip of an oral scanner where a window is formed, and including a top surface part supported on the upper surface of the tip and a left surface part and a right surface part supported on the left surface and the right surface of the tip, respectively; and a pair of shielding parts extending downward from the left surface part and the right surface part and positioned at the respective sides of the window.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present disclosure relates to an injection system for regulating the injecting of a material into a lung sample on the basis of artificial intelligence, and a method using same, the present injection system comprising: an injection device for injecting a material into a first sample which is a lung sample corresponding to a specific patient; a camera for photographing material injection states of second samples which are a plurality of lung samples corresponding to various patients; and a server configured to, on the basis of artificial intelligence, analyze and model images of the material injection states of the second samples acquired through the camera. The injection device comprises: a filler tank containing the material which is injected into the first sample; a pressure gauge for measuring the pressure at which the material is injected into the first sample; a pressure regulator for regulating the pressure at which the material is injected into the first sample; and a processor. The processor may be configured to check the pressure measured through the pressure gauge and regulate the checked pressure through the pressure regulator on the basis of an adequate material injection state acquired from the server.

IPC Classes  ?

• A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 3/09 - Supervised learning
• A61M 5/142 - Pressure infusion, e.g. using pumps

Abstract

Disclosed are an ultrasonic ocular surgery warning device using an ultrasonic sensor and a method thereof. The ultrasonic ocular surgery alarm device according to an embodiment of the present invention includes: an ultrasonic sensor, provided at one end of an ocular surgery device, for measuring the distance from a first point on an eyeball; and a processor that outputs a notification on the basis of the distance, from the first point to the ultrasonic sensor, transmitted from the ultrasonic sensor. The processor compares the distance, from the first point to the ultrasonic sensor, transmitted from the ultrasonic sensor with a notification reference, and outputs a distance-dependent notification according to the comparison result, differentially outputting the notification according to the identified distance from the first point to the ultrasonic sensor.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery
• G08B 21/02 - Alarms for ensuring the safety of persons

Abstract

The present invention relates to extramammary Paget disease biomarkers, such as SPDEF, ARG2, and ABEP1, and uses thereof that were discovered by exploring the molecular profile as well as performing a comprehensive genetic analysis of EMPD. The present invention investigates how EMPD evolves in the context of treatment and may elucidate a potential mechanism of progression to invasion. Furthermore, the biomarkers of the present invention may be usefully used in the diagnosis or treatment of extramammary Paget disease in that the tissue microenvironments and cell types associated with EMPD may be further characterized using spatial transcriptomics.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Disclosed is a pharmaceutical composition for preventing or treating colon cancer comprising extracellular vesicles loaded with an MACC1 inhibitor as an active ingredient. The pharmaceutical composition allows the extracellular vesicles loaded with the MACC1 inhibitor, a colon cancer-promoting factor, to deliver the inhibitor specifically to colon cancer cells and is characterized by high stability and biodegradability, thereby having a low risk of side effects and excellent drug delivery. Therefore, the pharmaceutical composition of the present disclosure is expected to be utilized in a variety of ways as a treatment for colon cancer with minimal risk of side effects and maximized anticancer ability.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/50 - Microcapsules
• A61P 35/00 - Antineoplastic agents

Abstract

Provided according to embodiments of the present invention is an apparatus and method for the prognosis of elderly depression patients, the apparatus comprises: a preprocessing unit for preprocessing brain imaging biomarkers of elderly depression patients; and a prediction unit for predicting a therapeutic effect of an anti-depressive drug in any given elderly depression patient for the brain imaging biomarkers and blood biomarkers or the drug administration effect evaluation results, through the pre-processed brain imaging biomarkers and blood biomarkers or drug administration effect evaluation results together with a prognosis prediction model trained to predict the effectiveness of antidepressant treatment in elderly depression patients by using the pre-processed brain imaging biomarkers and blood biomarkers.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

The present invention relates to a composition comprising human allogeneic dermal powder and platelet-rich plasma for treating musculoskeletal diseases, and a method for preparing same. The composition is administered to patients with musculoskeletal diseases so as to improve functions and alleviate pain, reduce the size of ruptured tendons and induce structural regeneration of tendons, and thus can be effectively used as a pharmaceutical composition for preventing or treating musculoskeletal diseases.

IPC Classes  ?

• A61K 35/36 - SkinHairNailsSebaceous glandsCerumenEpidermisEpithelial cellsKeratinocytesLangerhans cellsEctodermal cells
• A61K 35/16 - Blood plasmaBlood serum
• A61K 35/19 - PlateletsMegacaryocytes
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

The method for preventing or treating of cancer includes administering a pharmaceutical composition to a subject in need thereof comprising a compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof as an active ingredient. The method for preventing or treating of cancer includes administering a pharmaceutical composition to a subject in need thereof comprising a compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof as an active ingredient. The method for preventing or treating of cancer includes administering a pharmaceutical composition to a subject in need thereof comprising a compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof as an active ingredient. wherein the composition inhibits the growth of cancer cells.

IPC Classes  ?

• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 35/74 - Bacteria
• A61P 35/00 - Antineoplastic agents
• A61P 37/04 - Immunostimulants