Goods & Services

Software; Interfaces for computers; Artificial intelligence software for analysis; Machine learning software for healthcare; Artificial intelligence software for healthcare; Workout logging software; Health monitoring software; Software for monitoring, analysing, controlling and running physical world operations; Downloadable software applications; Mobile apps; Information retrieval applications; Web application and server software. Maintaining files and records concerning the medical condition of individuals; Health care cost review; Health care cost management; Business administration services in the field of healthcare; Data processing services in the field of healthcare; Compilation of statistics relating to health care utilization. Configuration of computer software; Software engineering; Updating of computer programs; Software development; Software design and development; Software customisation services; Smartphone software design; Design, development and programming of computer software; Advisory and information services relating to computer software; Programming of software for importing and managing data; Research and development of computer software; Research, development, design and upgrading of computer software; Support and maintenance services for computer software; Providing information about the design and development of computer software; Providing information about the design and development of computer hardware and software. Human healthcare services; Health counselling; Health risk assessment; Health assessment surveys; Preparation of reports relating to health care matters; Health advice and information services.

Abstract

It relates to Elvitegravir or a pharmaceutically acceptable salt thereof for use in the treatment of a bacterial infection caused by multidrug-resistant Gram-positive bacteria.

IPC Classes  ?

• A61K 31/47 - QuinolinesIsoquinolines
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/04 - Antibacterial agents

Abstract

The present invention provides an in vitro method for determining the X chromosome reactivation (X-Ra) level of a female subject, the method comprising the steps of (a) determining the methylation status of at least 10 CpG sites of Table 1 in a DNA-containing sample from the female subject; and (b) calculating the fraction of the CpG sites analyzed in step (a) that are hypomethylated. The invention also provides in vitro methods for determining the biological age of a female subject, diagnosis and/or prognosis of an age-related disease or disorder or an infection, and for determining the gestational age of a fetus.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

Bis(aminostyrylpyridinium) compounds of formula (I) and pharmaceutical acceptable salts thereof for use as a medicament. Additionally, multiple novel bis(aminostyrylpyridinium) compounds of formula (I) are provided. Specifically, compounds of formula (I) and compositions for use in the treatment of a disease whose etiology is based on protein aggregation. Particularly, compounds are useful in the treatment, prevention or amelioration of malaria, or symptoms, complications and/or sequelae thereof.

IPC Classes  ?

• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61P 33/06 - Antimalarials
• C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

Abstract

The present invention relates to cyclic peptides of a particular formula (I), X1X2X3X4CX6X7X8PX10X11X12X13CX15X16X17P (SEQ ID NO: 1) (I), fwherein X1 to X17 take several meanings, and X1 and D-Pro at position 18 are linked by a peptide bond; which cyclic peptides are useful as antimicrobial agents. The invention also relates to particular bicyclic compounds, in which cysteines at positions 5 and 14 are crosslinked by a disulfide bond. The invention also relates to pharmaceutical compositions comprising the said peptides and to the medical applications of the peptides or of the compositions comprising them.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 7/64 - Cyclic peptides containing only normal peptide links
• A61P 31/04 - Antibacterial agents
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

Bis(aminostyrylpyridinium) compounds of formula (I) and pharmaceutical acceptable salts thereof are provided for use as a medicament. Additionally, multiple novel bis(aminostyrylpyridinium) compounds of formula (I) are provided. The present invention relates to compounds of formula (I) and compositions for use in the treatment of a disease whose etiology is based on protein aggregation. Particularly, compounds are useful in the treatment, prevention or amelioration of malaria, or symptoms, complications and/or sequelae thereof.

IPC Classes  ?

• A61P 33/06 - Antimalarials
• C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• A61K 31/4427 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems

Abstract

A gold(III) complex, a conjugate of the gold(iII) complex, a pharmaceutical composition comprising the gold(III) complex and uses and a process for preparing the gold(III) complex. The complex comprises a group of (S{circumflex over ( )}C)-cyclometallated gold(III) complexes containing a 1,1-dithio ligand, which exhibit antibacterial activity against multiresistant microorganisms or against biofilm activity or biofilm disruption. The gold(III) complex has efficacy against a variety of microorganisms and low toxicity.

IPC Classes  ?

• C07F 9/6558 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
• A61P 31/04 - Antibacterial agents
• A01N 57/02 - Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having alternatively specified atoms bound to the phosphorus atom and not covered by a single one of groups , , ,
• A01N 57/08 - Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having alternatively specified atoms bound to the phosphorus atom and not covered by a single one of groups , , , containing heterocyclic radicals
• C07F 9/54 - Quaternary phosphonium compounds
• C07F 9/572 - Five-membered rings
• C07F 9/59 - Hydrogenated pyridine rings

Goods & Services

Computer software applications, downloadable. Medical services.

Goods & Services

Education; Providing of training; Entertainment; Sporting and cultural activities. Scientific end technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software. Medical services; Veterinary services; Hygiene and beauty care for people or animals; Agriculture, horticulture and forestry services.

Goods & Services

Education; providing of training; entertainment; sporting and cultural activities. Scientific and technological services and research and design relating thereto; industrial analysis and research services; except the design and development of computer hardware and software. Medical services; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services.

Goods & Services

Printed publications, books and magazines; catalogues, envelopes, letters, invoices, cards, diaries (other than electronic), posters, calendars, news sheets and printed matter in general; school supplies. Educational, training and teaching services; arranging and conducting of conferences, congresses, courses, colloquiums, seminars and symposiums; on-line electronic publication of books and newspapers, publication of texts (other than publicity texts); publication of books; book lending; correspondence courses and courses via global computer networks. Scientific research services for medical purposes; bacteriological, biological and chemical research; chemical analysis services; scientific and technological services and research and design relating thereto.