Provision of a cell production method, in particular, a method in which carriers are suspended and oscillated in a culture fluid, which is capable of reducing physical stress imposed on animal cells or a transfection reagent and improving cell culture efficiency or transfection efficiency.
Provision of a cell production method, in particular, a method in which carriers are suspended and oscillated in a culture fluid, which is capable of reducing physical stress imposed on animal cells or a transfection reagent and improving cell culture efficiency or transfection efficiency.
The cell production method includes a culturing step for culturing cells in a culture vessel 2, which holds at least cells, a culture fluid, and a carrier C while the vessel is oscillated on an oscillation plate 102, in which the oscillation plate 102 is tilted only in one direction with respect to a horizontal state.
Provided are a culture device and a cell separation method, which are capable of reducing damage to cells in a step for separating cells dispersed in a culture solution (and for extracting supernatant). A culture device 1 comprises: a culture tank 11 in which cells in a culture solution are cultured and in which at least oxygen is supplied to the culture solution; a sedimentation chamber 12 that has an opening 121 open to the culture solution; a cooling aggregation device 13 that cools the culture solution in the sedimentation chamber 12 and aggregates the cells contained in the culture solution in the sedimentation chamber 12; and a discharge mechanism 15 that discharges the supernatant of the culture solution in the sedimentation chamber 12.
C12M 1/00 - Apparatus for enzymology or microbiology
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
A sterile connector including: first and second connectors of the same shape including: a first (second) body portion including a first (second) joining surface; a first engaging member; and a first (second) fitting portion that fits with the first (second) tube, which is provided on a back surface of the first (second) joining surface of the first (second) body portion and which has a tip end portion for tightening the first (second) tube, an end face of the first (second) tube is configured to be positioned to project beyond the first (second) joining surface, and the sterile connector is configured such that when the first connector and the second connector are engaged such that the first joining surface faces the second joining surface, the end face of the first tube and the end face of the second tube are compressed with each other.
F16L 37/098 - Couplings of the quick-acting type in which the connection between abutting or axially-overlapping ends is maintained by locking members combined with automatic locking by means of flexible hooks
A61M 39/18 - Methods or apparatus for making the connection under sterile conditions, i.e. sterile docking
F16L 37/02 - Couplings of the quick-acting type in which the connection is maintained only by friction of the parts being joined
The present invention makes it so that a shopping cart (hereinafter, cart) comprising swivel casters will not travel independently, regardless of the slope of a road surface, and a movable conference desk or similar will not move after being placed, even if an external force is applied thereto. The present invention comprises: a swivel caster that includes a wheel body comprising two wheels and a rotation limiting member that is interposed between and unified with said wheels; a selection means that selects traveling or locking; a transmission means that transmits the selection result to a lock pin, and is flexible; and the lock pin, which is positioned at the center of swiveling of the swivel caster, is linked to the transmission means, and moves up and down. The rotation limiting member has an external shape that does not interfere with the lock pin in a specific rotation angle range, and does interfere with the same in a different angle range. When locking is selected, the lock pin lowers and locks if the rotation limiting member is in the specific rotation angle range, and in the other angle range, the lock pin interferes with the rotation limiting member but, due to the flexibility of the transmission means, does not press the rotation limiting member in a restrictive manner, and with a small movement of the cart afterward, the wheel body rotates and the lock pin lowers.
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (Japan)
ABLE Corporation (Japan)
Inventor
Uchida, Kazuhisa
Ishikawa, Shutaro
Tomita, Satoshi
Kanada, Kensaku
Abstract
A virus inactivation method is provided. The method includes irradiating a solution containing an artificially expressed antibody or antibody fragment with ultraviolet rays in the presence of a radical scavenger. The irradiating only aggregates 5% or less of the antibody or antibody fragment. A wavelength of the ultraviolet rays is 200 nm or longer and 315 nm or shorter. An irradiation amount of the ultraviolet rays is 300 mJ/cm2 or more. An irradiation time of the ultraviolet rays is 3 minutes or less. A concentration of the radical scavenger in the solution is 0.03 mM or more.
A61K 41/17 - Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
C12M 1/00 - Apparatus for enzymology or microbiology
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
6.
CELL PRODUCTION METHOD, CULTURE VESSEL, AND DEVICE FOR OSCILLATING CULTURE
In the present invention, with regards to a cell production method, in particular for a system in which a carrier is suspended and oscillated in a culture liquid, provided is a method capable of reducing the physical stress imposed on animal cells or a transfection reagent and of improving the cell culture efficiency or transfection efficiency. The cell production method includes a culturing step in which cell culture is performed in a culture vessel 2 which holds at least cells, a culture liquid, and a carrier C while the vessel is oscillated on an oscillation plate 102. The oscillation plate 102 is tilted in only one direction with respect to the horizontal state thereof.
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
C12M 1/00 - Apparatus for enzymology or microbiology
C12M 1/02 - Apparatus for enzymology or microbiology with agitation meansApparatus for enzymology or microbiology with heat exchange means
C12M 3/02 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (Japan)
ABLE CORPORATION (Japan)
Inventor
Uchida Kazuhisa
Ishikawa Shutaro
Tomita Satoshi
Kanada Kensaku
Abstract
The present invention inactivates viruses included in a protein medicine such as an antibody medicine while suppressing the formation of an aggregate. The virus inactivation method comprises an irradiation step for irradiating a solution containing artificially expressed protein with ultraviolet rays in the presence of a radical scavenger.
A61K 41/17 - Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
Provided are a cell separation method and a cell separator whereby cells can be efficiently separated by the sedimentation method even in the case of separating substances (cells) having a low sedimentation speed. This cell separation method, whereby cells are separated from a culture solution in which the cells are dispersed, comprises: step (S302) for preparing a separation container housing the culture solution in which the cells are separated; steps (S303-307) for leaving the separation container to stand so as to allow the cells to sediment toward the inner wall surface of the separation container; and step (S308) for enlarging the angle between the inner wall surface and the horizontal plane by changing the attitude of the separation container so as to move the cells, which have sedimented in the vicinity of the inner wall surface, to the bottom end of the separation container along the inner wall surface.
Provided is a method for manufacturing a sensor element that receives prescribed excitation light and emits fluorescence corresponding to the concentration of a desired component of an object to be measured, the method comprising: a step (S201) for preparing a fiber sheet constituted by a light-transmissive fibrous material; a step (S203) for imparting, to the fiber sheet, a solution in which a fluorescent substance is dispersed; and a step (S205) for fixing the fluorescent substance to the fiber sheet. Further provided is a sensor element that receives prescribed excitation light and emits fluorescence corresponding to the concentration of a desired component of an object to be measured, the sensor element comprising: a fiber sheet constituted by a light-transmissive fibrous material; and a fluorescent substance carried on the fiber sheet.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
A culture system (100) is provided with: a culture vessel (3) in which cells are to be cultured; a separation vessel (4) in which a liquid culture (30) is separated into a supernatant (41) and a precipitated liquid (42) containing cells by gravitational sedimentation; a first connecting passage (1A) and a second connecting passage (1B) through which the culture vessel (3) and the separation vessel (4) are connected to each other; a collecting passage (2) which is connected to the separation vessel (4) to collect the supernatant (41); and a control section (7) for controlling the flow of each of the liquid culture (30), the supernatant (41) and the precipitated liquid (42). The control section (7) is so configured that the liquid culture (30) can flow from the culture vessel (3) into the separation vessel (4) through the first connecting passage (1A), the supernatant (41) can flow out from the separation vessel (4) through the collecting passage (2) after the liquid culture (30) is allowed to stand, and subsequently the precipitated liquid (42) can be returned from the separation vessel (4) to the culture vessel (3) through the second connecting passage (1B).
This perfusion culture system 1 can be manufactured at relatively low costs by comprising: an introducing mechanism that introduces a culture medium held in a culturing tank 14 into a centrifuge tube 111; a rotary mechanism that centrifuges the culture medium inside the centrifuge tube 111 by rotating the centrifuge tube 111; and a discharging mechanism that discharges the culture medium from an opening OP provided on the centrifuge side of the centrifuge tube 111.
Provided are: a culture liquid treatment device which can be used continuously for a long period of time, and which is applicable to a perfusion culture device, etc.; and a liquid treatment device. The culture liquid treatment device comprises: a centrifugal separation tank 30 that is revolved around a rotation axis L to centrifugally separate a culture liquid W accommodated therein; a liquid feed pipe 40 that feeds the culture liquid; a pipe-shaped guide member 50 that is fixed at one end to the centrifugal separation tank and that guides the liquid feed pipe to the centrifugal separation tank; and a guide member retention tool 60 that retains the guide member so that the guide member can rotate around the rotation axis. The centrifugal separation tank is configured so as not to spin when being revolved, and the liquid feed pipe rotates relative to the guide member within the guide member in accordance with the revolution of the centrifugal separation tank.
This growth promotion method promotes the growth of an organism. An organism disposed in a growth environment has imparted thereto a 0.5-1000MHz high frequency AC electrical field having a frequency band such that water dielectric loss becomes smaller.
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
Provided are: a perfusion culture apparatus which can be utilized in long-duration culturing and which has a simple mechanism and is easy to use; and a centrifugal separator. The perfusion culture apparatus has a centrifugal separation tank 30 for centrifugally separating a culture solution W delivered from a culture tank 10, and a discharge mechanism 60 for causing a centrifugally separated supernatant of the culture solution to be discharged from the centrifugal separation tank. The centrifugal separation tank is provided with a cylindrical inner wall surface 32, and is configured so as to rotate about the center axis of the inner wall surface and thereby centrifugally separate the culture solution. The discharge mechanism includes a suction pipe 62 provided with a first end part 64 which faces the inner wall surface and is disposed closer to the center axis than the culture solution during centrifugal separation, and a second end part 66 which is disposed outside the centrifugal separation tank. In a state in which the centrifugal separation tank is rotated and the culture solution is centrifugally separated, the air in the centrifugal separation tank is sucked from the first end part of the suction pipe, and the centrifugally separated supernatant of the culture solution is thereby discharged, together with the air, from the second end part.
Provided are a culture vessel and a culture apparatus, each of which has a high gas dissolution rate and a high substance dispersion rate both in a liquid culture medium, has a simple mechanism, and is easy to handle. A culture vessel 100 is equipped with a vessel main body 10, a rotational axis 22 which is attached to the bottom of the vessel main body 10, a rotating body 30 which is rotatably attached to the rotational axis 22, a porous body 40 which is attached to the rotating body 30, and a flexible suction tube 50 which can be sucked at the porous body 40 and which is fixed to the porous body at one end thereof and is fixed to the vessel main body at the other end thereof. The porous body 40 is rotatably attached to the rotating body 30, and the suction tube 50 can rotate the porous body 40 relative to the rotating body 30 with the rotation of the rotating body 30.
C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
C12M 3/02 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
16.
CELL STIMULATION DEVICE, CELL STIMULATION METHOD, PRODUCTION METHOD FOR CULTURE PRODUCT, PRODUCTION METHOD FOR ISOLATED CELLS, AND CELL PROLIFERATION METHOD
A cell stimulation device that separates adherent cells that have adhered to a culture substrate, from the culture substrate by stimulating the cells. The cell stimulation device comprises an application means capable of applying an AC electric field between a first electrode and a second electrode that face each other and have the cells and a solution for cell immersion interposed therebetween. At least either the first electrode or the second electrode is not in contact with the cells or the solution.
A cell stimulation method that controls cell proliferation by stimulating cells without damaging the cells, by applying an AC electric field to the cells placed in an environment in which proliferation is possible.
A culturing process according to the present embodiment includes: a step of carrying out the setting of a culture apparatus 1 (step S100); a step of carrying out the conditioning of a pH sensor 40 (step S200); and a main culturing step (step S300). More specifically, in the process, the setting of the culture apparatus 1 (step S100) is carried out; and, after the completion of the preceding step, the step of carrying out the conditioning of the pH sensor 40 (step S200) is carried out; and subsequently the main culturing step is carried out using the culture apparatus 1 (step S300).
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
C12M 1/00 - Apparatus for enzymology or microbiology
C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
19.
CULTURE CONTAINER, CULTURE DEVICE, CULTURE PRODUCT AND LID BODY
Provided are a culture container which enables connection of a container to an external apparatus during a culture process using a roller bottle, a culture device, a culture product produced by using the same, and a lid body. The culture container 100 comprises a container 10 provided with an opening 14 having a cylindrical inner surface, and a lid body 20 to be mounted to the opening. The lid body is provided with an elastic sheet 60 which is disposed within the opening to thereby seal the opening, said elastic sheet being in the shape of a circle larger than the inner surface of the opening, and a holding member which fixes the inside of the elastic sheet while avoiding the periphery thereof to thereby hold the elastic sheet and dispose the elastic sheet within the opening, said holding member being constituted to be relatively rotatable with respect to the opening. The periphery of the elastic sheet is bent toward either the top side or the bottom side of the elastic sheet within the opening and, at the same time, the outer periphery of the elastic sheet is in contact with the inner surface of the opening.
The objective of the present invention is to provide a specimen measuring method with which an instrument having a simple structure can be utilized, and which can be applied to adhesion-dependent or planktonic cells, for example, and to provide a lid of multiwell plate, a specimen measuring kit, and a specimen measuring device. This method for measuring the state of a liquid specimen using a multiwell plate includes: a step of preparing a multiwell plate 10 having a liquid specimen S injected into each well 12; a step of placing a lid 20 onto the multiwell plate; and a step of measuring the state of the specimen. The lid includes a plurality of protruding portions 22 corresponding to each well in the multiwell plate, wherein the protruding portions are configured in such a way that, when the lid is attached to the multiwell plate, a distal end of each protruding portion comes into contact with the specimen while being separated from the bottom of the well. The step of measuring the state of the specimen includes a step of radiating exciting light from below the multiwell plate onto fluorescent material 30 provided at the distal ends of the protruding portions, and receiving fluorescence therefrom.
Provided are: a method for producing a freeze-dried product which is capable of efficiently producing a freeze-dried product with stable quality; a freeze-drying bag; and a freeze-drying device. This method for producing a freeze-dried product includes: a step for preparing a freeze-drying bag 10 which is provided with two surfaces (the first and second surfaces 12, 14) which face each other, a seal part 18 where the two surfaces are joined, and sterile ports 20 for sterilely supplying a substance 1 to be processed to a space S surrounded by the two surfaces and the seal part, at least a portion of the two surfaces being formed from a porous sheet 16 which is impermeable to liquid and bacteria; a step in which the substance 1 to be processed is supplied to the space through the sterile ports; and a step in which the substance to be processed is subjected to freeze-drying processing. In the step in which the substance to be processed is subjected to freeze-drying processing, moisture in the substance to be processed is sublimed into a gas, and the gas is discharged from the space through the porous sheet.
F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
B65D 81/26 - Adaptations for preventing deterioration or decay of contentsApplications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, fluids, e.g. exuded by contentsApplications of corrosion inhibitors or desiccators
22.
METHOD FOR PRODUCING CULTURE VESSEL AND METHOD FOR PRODUCING CULTURE VESSEL COMPONENT
Provided are a method for producing a culture vessel and a method for producing a culture vessel component wherewith a vessel suitable for various accessories can be easily and quickly produced. This method for producing a culture vessel comprises the steps of: molding a culture vessel component 24 having an ABS resin as the main material using a three-dimensional molding device for laminating heat-melted material into a three-dimensional object; applying a coating material 26, which does not affect the planned culture, to the component 24; hardening the coating material; and attaching the component 22 to the culture vessel.
Provided is a method and a device for screening continuous culture conditions, capable of selecting a cell line for continuous culture that hardly proliferates after reaching a steady state and that exhibits a high product generation rate with respect to the cell proliferation rate, and capable of selecting a continuous culture condition suitable for such cell line. This screening method and device are for selecting a suspension-type cell line for continuous culture on the basis of at least one index selected from: an index for the maximum {(product generation rate)/(cell proliferation rate)}; an index for the longest total time-period of a G0 period and a G1 period of the cell cycle; and an index for the minimum pathways in the metabolic flux.
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
C12M 1/00 - Apparatus for enzymology or microbiology
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Chemical processing machines and apparatus; plastic
processing machines and apparatus; pumps and parts thereof. Laboratory apparatus and instruments; bioreactors for cell
culture; disposable plastic bioreactors for cell culture;
measuring and testing machines and instruments; software of
data processing. Retail services or wholesale services for chemical
processing machines and apparatus; retail services or
wholesale services for laboratory apparatus and instruments;
retail services or wholesale services for measuring and
testing machines and instruments.
09 - Scientific and electric apparatus and instruments
37 - Construction and mining; installation and repair services
Goods & Services
Laboratory apparatus and instruments; bioreactors for cell
culture; disposable plastic bioreactors for cell culture;
measuring and testing machines and instruments. Repair and maintenance of laboratory apparatus and
instruments; repair and maintenance of measuring and testing
machines and instruments.
09 - Scientific and electric apparatus and instruments
37 - Construction and mining; installation and repair services
Goods & Services
Laboratory apparatus and instruments, namely, bioreactors; bioreactors for cell culture; [ disposable plastic bioreactors for cell culture; ] laboratory equipment, namely, porous ventilation test tubes for cell culture; laboratory equipment, namely, plastic test tubes for liquid transportation for laboratory apparatus and instruments; tubes for peristaltic pumps for use with laboratory apparatus and instruments; laboratory filters and filter cartridges for filtration as filtering devices and structural parts thereof for experiment or examination; cell culture vessels in the nature of cell culture dishes, and structural parts thereof; laboratory filters, namely, cell and gene separation filtering devices for a study in laboratories; cell culture vessels, namely, cell culture dishes for laboratory use; shaking culture vessels, namely, cell culture dishes for laboratory use; cell culture apparatus for laboratory use, namely, tissue culture flasks; column devices for chromatography, namely, chromatography columns for laboratory use and structural parts thereof; automatic sample extractors, namely, automatic pipettes; magnetic stirrers for laboratory use; biological sample storing containers for use in laboratory research and experiment; saccharides measuring and testing machines and instruments; sensors for measuring pH value, not for medical use; oxygen sensors, not for medical use ; gas sensors for measuring gas concentration; apparatus for analyzing gases; turbidimeters; mass spectroscopes [ Repair and maintenance of laboratory apparatus and instruments; repair and maintenance of measuring and testing machines and instruments ]
Retail and wholesale store services featuring chemical processing machines and apparatus; retail and wholesale store services featuring bioreactors for cell culture and instruments; retail and wholesale store services featuring measuring and testing machines and instruments
28.
LID FOR REACTION CONTAINER BODY AND REACTION CONTAINER BODY LID SET PROVIDED WITH SAID LID FOR REACTION CONTAINER BODY
This lid for a reaction container body covers the upper part of a reaction container body comprising a single reaction container in which the upper surface is open, or a plurality of the reaction containers disposed so as to be connected on a plane. A gap is formed between the reaction container and the lid for a reaction container body while the lid for a reaction container covers the upper part of the reaction container, and the lid for a reaction container body is provided with a lid part covering the upper part of the reaction container and a side wall handing down from the outer periphery of the lid part. The invention is characterized in having a cooling part on at least the upper surface of the lid body.
OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION (Japan)
ABLE CORPORATION (Japan)
Inventor
Nakazumi, Hiroyuki
Maeda, Takeshi
Ishikawa, Shutaro
Abstract
Provided are: an organic-inorganic hybrid thin film which is suppressed in dissolution of a dye, while having high durability in terms of radiation; and a pH sensor which uses this organic-inorganic hybrid thin film. This organic-inorganic hybrid thin film contains a polysiloxane skeleton and an organic salt that is incorporated into the polysiloxane skeleton. The organic salt is configured from an anion having a dye skeleton and a cation having a silicon-containing group; and the cation is incorporated into the polysiloxane skeleton together with the anion via the silicon atom contained in the silicon-containing group.
C08G 77/48 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms
This particulate matter supply device is characterized in that: the particulate matter supply device supplies particulate matter to liquid in a culture tank or a water tank; the particulate matter supply device is provided with a particulate matter supply tube for supplying the particulate matter to the tank, and a drying devicefor drying the interior of a portion near a discharge opening of the particulate matter supply tube; the discharge opening, which is located at an end of the particulate matter supply tube, faces the liquid surface in the tank; and after drying the interior of the portion near the discharge opening, the particulate matter is introduced into the particulate matter supply tube.
The present invention addresses the problem of providing a reaction device that doubles as a centrifuge so as to be able to effectively carrying out solid-liquid separation by centrifugation, and in which a reaction vessel has a simple internal structure. The present invention provides a reaction device that doubles as a centrifuge is provided with: a bottomed cylindrical reaction vessel having an upper portion that opens at the periphery; a substantially cylindrical housing for housing the reaction vessel inside; and a drive unit for, by means of a shaft, rotationally driving the reaction vessel around the axis of the shaft. After a content liquid to be subjected to a reaction is reacted in the reaction vessel, the reaction vessel is rotationally driven around the axis to carry out solid-liquid separation on a reaction liquid by centrifugal force and cause overflow of a supernatant liquid from the opening end at the upper portion of the reaction vessel.
B04B 1/02 - Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles without inserted separating walls
B04B 5/12 - Centrifuges in which rotors other than bowls generate centrifugal effects in stationary containers
B04B 9/08 - Arrangement or disposition of transmission gearing
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
A logistics-solution intranet system of the present invention includes a data bank that stores information regarding predetermined logistics, planning means that plans a process of a logistics solution based on the information regarding the predetermined logistics, execution means that transmits execution process information that an operation target device executes, based on the process planned by the planning means, a controller that transmits a work state of the operation target device, optimum process deployment means that controls the entire logistics-solution intranet system based on the information regarding the predetermined logistics, and a network that mutually communicatively couples the planning means, the execution means, and the optimum process deployment means to the controller, and the planning means, the execution means, and the optimum process deployment means are executed in a communication information process (a conversation method), and use identical hardware to be configured using an identical operating system.
This logistics solution and intranet system comprises: a data bank for storing information related to prescribed logistics; a planning means for planning processing for a logistics solution on the basis of the information related to the prescribed logistics; an execution means for, on the basis of processing planned by the planning means, transmitting execution processing information that will be executed by an operation device; a controller for transmitting the work state of the operation device; an optimal-processing deployment means for, on the basis of the information related to the prescribed logistics, performing overall control of the logistics solution and intranet system; and a network that mutually and communicably connects the planning means, execution means, optimal-processing deployment means, and controller. The planning means, execution means, and optimal-processing deployment means are communicated by communication information processing (conversation method), and are configured using the same hardware and using the same operating system.
Disclosed herein is a cell culture apparatus that can achieve appropriate culture conditions. The cell culture apparatus (1) includes: a cylindrical culture vessel (10) that holds a culture liquid containing cells; a supporting column (20) that stands upright in a center of an inner surface of a bottom (12) in the culture vessel; and a stirring device (30) that includes an attaching portion (32) that is attached to an upper portion of the supporting column so as to be rotatable relative to the supporting column and a stirring blade (34) whose upper portion is fixed to the attaching portion so as to rotate around the supporting column.
Provided is a cell culturing device capable of having a simple configuration and performing cell culturing well. The cell culturing device (5) comprises: a culture tank (15) housing a culture solution including cells; a shaft member (17) having at least part thereof arranged inside the culture tank (15); an agitation mechanism (19) supported by the shaft member (17), arranged inside the culture tank (15), and having at least a pair of agitation blades (27) rotatably provided that have the shaft member (17) as the rotation center thereof; and a filter (21) provided so as to come in contact with the shaft member (17) and attracting the culture solution from the culture tank (15) and/or supplying the culture solution to the culture tank (15). The shaft member (17) is at least partially hollow, has openings (17a, 17b) provided that guide the culture solution therein or guide the culture solution out from the interior thereof, cannot rotate, and draws the culture solution from the culture tank (15) and/or supplies the culture solution to the culture tank (15), via the filter (21) and the interior of the shaft member (17).
A device for driving stirring means (4, 5) for a culture tank (3) and equipped with a turbine (6) for rotating and driving the stirring means (4, 5), a housing (7) for housing the turbine (6), an injector (8) for injecting a gas for driving into the turbine (6) in the housing (7), a discharge part (9) for connecting the interior and exterior of the housing (7), and a gas-supply means (10) for supplying the gas for driving to the injector (8), wherein configuring a structure for rotating and driving the stirring means (4, 5) by using the turbine (6) which rotates due to the pressure of the gas makes it possible to drastically simplify the structure by decreasing the number of components therein, and to make production comparatively inexpensive.
The present invention addresses the problem of providing the feature of easily zero-point calibrating an oximeter by using an injection-needle-shaped puncturing means. The present invention provides a calibration tool for an oximeter which uses an injection-needle-shaped puncturing means. The calibration tool is equipped with an air-tight container and a deoxygenation agent placed inside the container. The container is configured in a manner such that at least a section thereof is capable of being punctured by the puncturing means, and so as to retain the air-tightness thereof when the puncturing means punctures the container.
G01N 1/00 - SamplingPreparing specimens for investigation
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
The present invention addresses the problem of providing a lid section which can removably hermetically close the gaps between the lid section and the opening of a cultivation tank and between a through-hole in the lid section and an object which penetrates through the through-hole. The present invention provides a lid section for a cultivation tank, the lid section being formed by laying plate-like base materials over each other. An annular elastic body which is a hermetically closing member is fitted between the plate-like base materials. The annular elastic body causes the cultivation tank and the lid section to be in close contact with each other, and the opening of the cultivation tank is hermetically closed. The plate-like base materials respectively have openings at position at which the openings are superposed on each other when the plate-like base materials are laid over each other. The openings form a through-hole which penetrates through the lid section. An annular elastic body which is another hermetically closing member is fitted between the plate-like base materials so as to be located around the through-hole, and this annular elastic body hermetically closes the gap between the through-hole and an object which penetrates through the through-hole.
Provided is a cell culture apparatus capable of actualizing a suitable culture environment. The cell culture apparatus (1) is provided with a cylindrical culture vessel (10) housing a culture medium containing cells; a support (20) standing upright from the center of the inner surface of the bottom (12) inside the culture vessel; and a stirring means (30) having an attaching portion (32) mounted, rotatably relative to the support, on the upper part of the support, and an impeller (34), the upper part of which is secured to the attaching portion, that rotates with the support as the rotation center.
C12M 3/02 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
C12M 1/02 - Apparatus for enzymology or microbiology with agitation meansApparatus for enzymology or microbiology with heat exchange means
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
The purpose of the present invention is to provide a technique for optically measuring the turbidity of a culture solution in a culture tank from outside the culture tank. The present invention provides a turbidity measurement device for measuring the turbidity of a culture solution from outside a culture tank, the turbidity measurement device comprising: a transparent part provided in a tank wall of a culture tank; a reflecting mirror disposed in a culture solution in the culture tank; a light emitter for irradiating light to the reflecting mirror via the transparent part, the light emitter being disposed outside the culture tank; and a detecting light receiver for receiving light from the direction of the reflecting mirror via the transparent part.
Disclosed is a technique for inhibiting the production of methane using a methane-producing bacterium. The use of a methane-producing bacterium Alcaligenes faecalis enables the inhibition of the production of methane.
Provided is an ion-concentration-measuring combination electrode that includes a glass electrode and a reference electrode, in which the internal solution of the reference electrode is prevented from leaking and entering above the sealing means of a reference electrode chamber, in which insulation between the internal electrode of the glass electrode and the internal electrode of the reference electrode is ensured, and with which ion concentrations can be measured stably. The ion-concentration-measuring combination electrode includes a glass electrode and a reference electrode having a silver-silver chloride internal electrode, and is characterized in that: the internal electrode and the internal solution of the reference electrode are placed inside an outer cylindrical tube; a reference electrode chamber is formed inside the outer cylindrical tube and around a glass support tube that passes through the outer cylindrical tube substantially along the central axis thereof; a sealing means which seals the upper face of the reference electrode chamber is made up of an annular silver member through which the glass support tube passes along the central axis, and annular elastic members each for sealing between the silver member and the glass support tube and for sealing between the silver member and the outer cylindrical tube in a liquid-tight fashion; and the internal electrode of the reference electrode is connected via the silver member to a terminal provided for the reference electrode.
Provided is a reactor that performs environmental regulation of, for example, the pH or dissolved oxygen concentration of a contained liquid that is accommodated therein by supplying a gas from a gas source into the interior from the bottom. A communicating tube that passes through the bottom and the contained liquid and opens above the liquid surface is provided inside the reactor, and the gas is supplied into the space above the liquid surface via the communicating tube. This makes it possible to dissolve the gas in the contained liquid gradually while preventing generation of gas bubbles or foam. Moreover, the range of fluctuation in the pH or dissolved oxygen concentration of the contained liquid is reduced, and the environmental regulation thereof is made smooth.
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
G01N 1/00 - SamplingPreparing specimens for investigation
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
