Contraf-Nicotex-Tobacco GmbH

Germany

Back to Profile

1-18 of 18 for Contraf-Nicotex-Tobacco GmbH Sort by
Query
Aggregations
IP Type
        Patent 14
        Trademark 4
Jurisdiction
        World 9
        United States 4
        Canada 3
        Europe 2
Date
New (last 4 weeks) 1
2025 June 1
2025 May 3
2025 March 2
2025 (YTD) 7
See more
IPC Class
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond 8
A61K 31/465 - NicotineDerivatives thereof 4
A61P 25/34 - Tobacco-abuse 4
A24B 13/00 - Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettesChewing tobaccoSnuff 3
A24B 15/30 - Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances 3
See more
NICE Class
05 - Pharmaceutical, veterinary and sanitary products 4
30 - Basic staples, tea, coffee, baked goods and confectionery 4
34 - Tobacco; smokers' articles 4
35 - Advertising and business services 4
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services 4
See more
Status
Pending 4
Registered / In Force 14

1.

ORAL PRODUCT FOR DELIVERY OF NICOTINE COMPRISING A NICOTINE SALT OF A FATTY ACID

      
Application Number EP2024084929
Publication Number 2025/125085
Status In Force
Filing Date 2024-12-05
Publication Date 2025-06-19
Owner CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Ellerichmann, Thomas
  • Belz, Markus
  • König, Thorsten
  • Parsons, Rory

Abstract

The invention relates to an oral product for delivery of nicotine comprising or consisting of a composition comprising at least one nicotine salt of a fatty acid, at least one carrier, and water in an amount of less than 25% by weight, preferably in an amount of 5 % by weight to 15 % by weight, more preferably 5 % by weight to 10 % by weight, based on the total weight of the composition. The invention further relates to a method for preparing an oral product.

IPC Classes  ?

  • A24B 13/00 - Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettesChewing tobaccoSnuff
  • A24B 15/30 - Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances

2.

Chiral Synthesis of Nornicotine and Nicotine

      
Application Number 19029517
Status Pending
Filing Date 2025-01-17
First Publication Date 2025-05-22
Owner
  • SIEGFRIED AG (Switzerland)
  • CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Straková, Karolína
  • Müller, Dominik Simon
  • Van Vegten, Cornelis Hendrik
  • Zeller, Florian Daniel
  • Debnar, Thomas

Abstract

The present invention relates to a method of producing nornicotine through enantioselective hydrosilylation of myosmine and a composition produced thereby, as well as a composition comprising nornicotine and a catalyst, wherein the catalyst is an organic chiral Lewis base, and a catalyst. The present invention also relates to a method of producing nicotine or a salt thereof from myosmine through enantioselective hydrosilylation of myosmine to nornicotine and further reacting the nornicotine to nicotine or a salt thereof, and a composition produced thereby, as well as a composition comprising nicotine, or a salt thereof, and a catalyst, wherein the catalyst.

IPC Classes  ?

  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond

3.

SNP

      
Application Number 1855657
Status Registered
Filing Date 2025-01-23
Registration Date 2025-01-23
Owner CONTRAF-NICOTEX-TOBACCO GmbH (Germany)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 30 - Basic staples, tea, coffee, baked goods and confectionery
  • 34 - Tobacco; smokers' articles
  • 35 - Advertising and business services
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Nicotine gum for use as an aid to stop smoking; nicotine patches for use as aids to stop smoking; dragees [medicines]. Chewing candy; dragees [non- medicated confectionery]; tablets (non-medicated-) made of glucose with a caffeine base. Liquid solutions for use in electronic cigarettes; tobacco; tobacco products; tobacco substitutes; tobacco and tobacco substitutes; tobacco products for the purpose of being heated; cigarettes containing tobacco substitutes; cigarettes containing tobacco substitutes, not for medical purposes; flavorings, other than essential oils, for tobacco substitutes; flavourings, other than essential oils, for tobacco; loose, rolling and pipe tobacco; flavourings, other than essential oils, for use in electronic cigarettes; electronic cigarette liquid [e-liquid] comprised of propylene glycol; electronic cigarette liquid [e-liquid] comprised of vegetable glycerin; cartridges sold filled with chemical flavorings in liquid form for electronic cigarettes; electronic cigarette liquid [e-liquid] comprised of flavorings in liquid form used to refill electronic cigarette cartridges; chemical flavorings in liquid form used to refill electronic cigarette cartridges; chewing tobacco; tobacco free oral nicotine pouches [not for medical use]. Services of a retailer in relation to articles for use with tobacco. Quality testing, quality control and scientific research in the field of environmental protection and sustainability in relation to tobacco and tobacco products; technological services relating to the implementation of scientific studies and results in the field of sustainability of tobacco and nicotine products. Agricultural advice; agricultural consultancy.

4.

NONWOVEN PRODUCT FOR ORAL DELIVERY OF A SUBSTANCE, AND METHOD OF MANUFACTURING THE SAME

      
Application Number 18940422
Status Pending
Filing Date 2024-11-07
First Publication Date 2025-05-15
Owner
  • Nonwovenn Ltd (United Kingdom)
  • Contraf-Nicotex-Tobacco GmbH (Germany)
Inventor
  • Gentilcore, Giovanni
  • Hill, David
  • Ellerichmann, Thomas
  • Belz, Markus
  • König, Thorsten

Abstract

A product for oral delivery of a substance in which the substance is retained with a layered structure of nonwoven materials that provides structural integrity capable of withstanding a chewing action, together with a desirable mouth feel and appealing product form factor. The substance may be a gel material that is held within a plurality of layers of nonwoven fabric that are secured together as a consolidated web by physical consolidation technique such as hydroentanglement, stitching, embossing, needle felting/punching.

IPC Classes  ?

  • D04H 1/498 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling by needling or like operations to cause entanglement of fibres entanglement of layered webs
  • A24F 23/02 - Tobacco pouches
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • D04H 1/541 - Composite fibres e.g. sheath-core, sea-island or side-by-sideMixed fibres

5.

ORAL PRODUCT COMPRISING THEOBROMINE

      
Document Number 03269651
Status Pending
Filing Date 2024-09-12
Open to Public Date 2025-03-20
Owner CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Belz, Markus
  • Ellerichmann, Thomas
  • Konig, Thorsten

IPC Classes  ?

  • A24B 13/00 - Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettesChewing tobaccoSnuff
  • A24B 15/30 - Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances

6.

ORAL PRODUCT COMPRISING THEOBROMINE

      
Application Number EP2024075549
Publication Number 2025/056711
Status In Force
Filing Date 2024-09-12
Publication Date 2025-03-20
Owner CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Belz, Markus
  • Ellerichmann, Thomas
  • König, Thorsten

Abstract

The invention relates to an oral product for delivery of at least one active ingredient comprising or consisting of - a pouch defining a cavity and - a composition comprising the at least one active ingredient and a carrier selected from the group consisting of, cocoa bean, in particular cocoa bean nibs or cocoa bean powder, coffee bean, cellulose, plant fibres, polysaccharides, oligosaccharides, polyols, and mixtures of at least two of the afore-said carriers, wherein the composition is within the cavity of the pouch and the at least one active ingredient is theobromine. The invention further relates to a method for producing an oral product.

IPC Classes  ?

  • A24B 13/00 - Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettesChewing tobaccoSnuff
  • A24B 15/30 - Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances

7.

SNP

      
Application Number 019132131
Status Pending
Filing Date 2025-01-16
Owner Contraf-Nicotex-Tobacco GmbH (Germany)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 30 - Basic staples, tea, coffee, baked goods and confectionery
  • 34 - Tobacco; smokers' articles
  • 35 - Advertising and business services
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Nikotinkaugummi zur Raucherentwöhnung; Nikotinpflaster zur Raucherentwöhnung; Dragees [Arzneimittel]. Kaubonbons; Dragees [nicht medizinische Süßwaren]; Dragees [nicht medizinisch] aus Glukose auf Koffeinbasis. Nikotinliquide für elektronische Zigaretten; Tabak; Tabakerzeugnisse; Tabakersatzstoffe; Tabak und Tabakersatzstoffe; Tabakerzeugnisse zum Erhitzen; Tabakersatzstoffe enthaltende Zigaretten; Zigaretten aus Tabakersatzstoffen, nicht für medizinische Zwecke; Aromen für Tabakersatzstoffe, ausgenommen ätherische Öle; Aromen für Tabak, ausgenommen ätherische Öle; Loser Tabak zum selbst drehen und für die Pfeife; Liquide für elektronische Zigaretten; Aromen für elektronische Zigaretten, ausgenommen ätherische Öle; Liquide für elektronische Zigaretten [E-Liquide] aus Propylenglykol; Liquide für elektronische Zigaretten [E-Liquide] aus pflanzlichem Glyzerin; Mit flüssigen chemischen Aromastoffen gefüllte Patronen für elektronische Zigaretten; Liquide für elektronische Zigaretten [E-Liquid], bestehend aus Aromastoffen in flüssiger Form zum Nachfüllen von Patronen für elektronische Zigaretten; Chemische Aromastoffe in flüssiger Form zum Nachfüllen von Patronen für elektronische Zigaretten; Kautabak; Tabakfreie Nikotinbeutel zur oralen Verwendung [nicht für medizinische Zwecke]. Einzel- und Großhandelsdienstleistungen in Bezug auf Artikel zur Verwendung mit Tabak. Dienstleistungen im Bereich Qualitätsprüfung und Qualitätskontrolle, Nachhaltigkeit und Umweltschutz in Bezug auf Tabak und Tabakerzeugnisse; Durchführung und wissenschaftliche Studien und Ergebnisse in Bezug auf Nachhaltigkeit von Tabak und Nikotinprodukten. Landwirtschaftliche Beratung; Landwirtschaftliche Beratungsdienste.

8.

METHOD OF PURIFYING CANNABINOID COMPONENTS FROM PLANT EXTRACTS

      
Application Number EP2024053783
Publication Number 2024/193910
Status In Force
Filing Date 2024-02-15
Publication Date 2024-09-26
Owner
  • SIEGFRIED AG (Switzerland)
  • CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Van Vegten, Cornelis Hendrik
  • Wirz, Yannick

Abstract

The invention provides a new and effective way to isolate and purify organic compounds from hemp and/or another plant from the Cannabaceae family and/or a part of the plant.

IPC Classes  ?

9.

ORAL PRODUCT FOR DELIVERY OF AN ACTIVE INGREDIENT

      
Application Number EP2024051466
Publication Number 2024/160586
Status In Force
Filing Date 2024-01-23
Publication Date 2024-08-08
Owner CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Ellerichmann, Thomas
  • Belz, Markus
  • König, Thorsten

Abstract

The invention relates to an oral product for delivery of an active ingredient comprising or consisting of at least one layer and a composition comprising a hydrogel forming component and the active ingredient. The oral product is capable of releasing the active ingredient without the need of chewing the oral product.

IPC Classes  ?

  • A24B 15/16 - Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
  • A61K 9/00 - Medicinal preparations characterised by special physical form

10.

CHIRAL SYNTHESIS OF NORNICOTINE AND NICOTINE

      
Application Number EP2023073883
Publication Number 2024/047152
Status In Force
Filing Date 2023-08-31
Publication Date 2024-03-07
Owner
  • SIEGFRIED AG (Switzerland)
  • CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Straková, Karolína
  • Müller, Dominik Simon
  • Van Vegten, Cornelis Hendrik
  • Zeller, Florian Daniel
  • Debnar, Thomas

Abstract

The present invention relates to a method of producing nornicotine through enantioselective hydrosilylation of myosmine and a composition produced thereby, as well as a composition comprising nornicotine and a catalyst, wherein the catalyst is an organic chiral Lewis base, and a catalyst. The present invention also relates to a method of producing nicotine or a salt thereof from myosmine through enantioselective hydrosilylation of myosmine to nornicotine and further reacting the nornicotine to nicotine or a salt thereof, and a composition produced thereby, as well as a composition comprising nicotine, or a salt thereof, and a catalyst, wherein the catalyst is an organic chiral Lewis base.

IPC Classes  ?

  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

11.

CNT

      
Application Number 1612365
Status Registered
Filing Date 2021-04-15
Registration Date 2021-04-15
Owner Contraf-Nicotex-Tobacco GmbH (Germany)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 30 - Basic staples, tea, coffee, baked goods and confectionery
  • 34 - Tobacco; smokers' articles
  • 35 - Advertising and business services
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Nicotine gum for use as an aid to stop smoking; nicotine patches for use as aids to stop smoking; dragees [medicines]. Chewing candy; dragees [non-medicated confectionery]; tablets (non-medicated -) made of glucose with a caffeine base. Liquid solutions for use in electronic cigarettes; tobacco; tobacco products; tobacco substitutes; tobacco and tobacco substitutes; tobacco products for the purpose of being heated; cigarettes containing tobacco substitutes; cigarettes containing tobacco substitutes, not for medical purposes; flavorings, other than essential oils, for tobacco substitutes; flavourings, other than essential oils, for tobacco; loose, rolling and pipe tobacco; flavourings, other than essential oils, for use in electronic cigarettes; electronic cigarette liquid [e-liquid] comprised of propylene glycol; electronic cigarette liquid [e-liquid] comprised of vegetable glycerin; cartridges sold filled with chemical flavorings in liquid form for electronic cigarettes; electronic cigarette liquid [e-liquid] comprised of flavorings in liquid form used to refill electronic cigarette cartridges; chemical flavorings in liquid form used to refill electronic cigarette cartridges; chewing tobacco; tobacco free oral nicotine pouches [not for medical use]. Wholesale services in relation to articles for use with tobacco. Agricultural advice; agricultural consultancy.

12.

Enantiomeric separation of racemic nicotine by addition of an O,O″-disubstituted tartaric acid enantiomer

      
Application Number 16956964
Grant Number 11279685
Status In Force
Filing Date 2018-12-18
First Publication Date 2020-10-22
Grant Date 2022-03-22
Owner
  • SIEGFRIED AG (Switzerland)
  • CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Weber, Beat Theodor
  • Pan, Ben

Abstract

The present invention relates to a method of separating racemic nicotine of Formula (1-a) as a mixture of the (R)- and (S)-enantiomers into the enantiomerically pure (S)- and (R)-nicotine represented by Formula (1-b) and (1-c), by adding a mixture of the L- and the D-enantiomer of a O,O′-disubstituted tartaric acid, wherein the molar ratio of the L- to the D-enantiomer is from 80:20 to 95:5, and obtaining the (S)-nicotine of formula (1-b), or by adding O,O′-dibenzoyl-D-tartaric acid and obtaining the (R)-nicotine of formula (1-c).

IPC Classes  ?

  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond

13.

Preparation of racemic nicotine by reaction of ethyl nicotinate with N-vinylpyrrolidone in the presence of an alcoholate base and subsequent process steps

      
Application Number 16957006
Grant Number 11407730
Status In Force
Filing Date 2018-12-18
First Publication Date 2020-10-22
Grant Date 2022-08-09
Owner
  • Siegfried AG (Switzerland)
  • Contraf-Nicotex-Tobacco GmbH (Germany)
Inventor
  • Weber, Beat Theodor
  • Lothschütz, Christian
  • Pan, Ben

Abstract

The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine; (iii) reducing the myosmine to nornicotine using a reducing agent; and (iv) methylating the nornicotine to obtain the racemic nicotine.

IPC Classes  ?

  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond

14.

CNT

      
Application Number 018217437
Status Registered
Filing Date 2020-03-30
Registration Date 2020-07-16
Owner Contraf-Nicotex-Tobacco GmbH (Germany)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 30 - Basic staples, tea, coffee, baked goods and confectionery
  • 34 - Tobacco; smokers' articles
  • 35 - Advertising and business services
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Nicotine gum for use as an aid to stop smoking; Nicotine patches for use as aids to stop smoking; Dragees [medicines]. Chewing candy; Dragees [non-medicated confectionery]; Tablets (Non-medicated -) made of glucose with a caffeine base. Liquid solutions for use in electronic cigarettes; Tobacco; Tobacco products; Tobacco substitutes; Tobacco and tobacco substitutes; Tobacco products for the purpose of being heated; Cigarettes containing tobacco substitutes; Cigarettes containing tobacco substitutes, not for medical purposes; Flavorings, other than essential oils, for tobacco substitutes; Flavourings, other than essential oils, for tobacco; Loose, rolling and pipe tobacco; Flavourings, other than essential oils, for use in electronic cigarettes; Electronic cigarette liquid [e-liquid] comprised of propylene glycol; Electronic cigarette liquid [e-liquid] comprised of vegetable glycerin; Cartridges sold filled with chemical flavorings in liquid form for electronic cigarettes; Electronic cigarette liquid [e-liquid] comprised of flavorings in liquid form used to refill electronic cigarette cartridges; Chemical flavorings in liquid form used to refill electronic cigarette cartridges; Chewing tobacco; Tobacco free oral nicotine pouches [not for medical use]. Wholesale services in relation to articles for use with tobacco. Agricultural advice; Agricultural consultancy.

15.

ENANTIOMERIC SEPARATION OF RACEMIC NICOTINE BY ADDITION OF AN O,O'-DISUBSTITUTED TARTARIC ACID ENANTIOMER

      
Document Number 03085208
Status In Force
Filing Date 2018-12-18
Open to Public Date 2019-06-27
Grant Date 2023-05-23
Owner
  • SIEGFRIED AG (Switzerland)
  • CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Weber, Beat
  • Pan, Ben

Abstract

The present invention relates to a method of separating racemic nicotine of Formula (l-a) as a mixture of the (R)- and (S)-enantiomers into the enantiomerically pure (S)- and (R)-nicotine represented by Formula (l-b) and (l-c), by adding a mixture of the L- and the D-enantiomer of a O,O'-disubstituted tartaric acid, wherein the molar ratio of the L- to the D-enantiomer is from 80:20 to 95:5, and obtaining the (S)-nicotine of formula (l-b), or by adding O,O'-dibenzoyl-D-tartaric acid and obtaining the (R)-nicotine of formula (l-c).

IPC Classes  ?

  • A61K 31/465 - NicotineDerivatives thereof
  • A61P 25/34 - Tobacco-abuse
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond

16.

PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS

      
Application Number EP2018085437
Publication Number 2019/121644
Status In Force
Filing Date 2018-12-18
Publication Date 2019-06-27
Owner
  • SIEGFRIED AG (Switzerland)
  • CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Weber, Beat
  • Lothschütz, Christian
  • Pan, Ben

Abstract

The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine; (iii) reducing the myosmine to nornicotine using a reducing agent; and (iv) methylating the nornicotine to obtain the racemic nicotine.

IPC Classes  ?

  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • A61K 31/465 - NicotineDerivatives thereof
  • A61P 25/34 - Tobacco-abuse

17.

PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS

      
Document Number 03085245
Status In Force
Filing Date 2018-12-18
Open to Public Date 2019-06-27
Grant Date 2023-06-13
Owner
  • SIEGFRIED AG (Switzerland)
  • CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Weber, Beat
  • Lothschutz, Christian
  • Pan, Ben

Abstract

The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine; (iii) reducing the myosmine to nornicotine using a reducing agent; and (iv) methylating the nornicotine to obtain the racemic nicotine.

IPC Classes  ?

  • A61K 31/465 - NicotineDerivatives thereof
  • A61P 25/34 - Tobacco-abuse
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond

18.

ENANTIOMERIC SEPARATION OF RACEMIC NICOTINE BY ADDITION OF AN O,O'-DISUBSTITUTED TARTARIC ACID ENANTIOMER

      
Application Number EP2018085444
Publication Number 2019/121649
Status In Force
Filing Date 2018-12-18
Publication Date 2019-06-27
Owner
  • SIEGFRIED AG (Switzerland)
  • CONTRAF-NICOTEX-TOBACCO GMBH (Germany)
Inventor
  • Weber, Beat
  • Pan, Ben

Abstract

The present invention relates to a method of separating racemic nicotine of Formula (l-a) as a mixture of the (R)- and (S)-enantiomers into the enantiomerically pure (S)- and (R)-nicotine represented by Formula (l-b) and (l-c), by adding a mixture of the L- and the D-enantiomer of a O,O'-disubstituted tartaric acid, wherein the molar ratio of the L- to the D-enantiomer is from 80:20 to 95:5, and obtaining the (S)-nicotine of formula (l-b), or by adding O,O'-dibenzoyl-D-tartaric acid and obtaining the (R)-nicotine of formula (l-c).

IPC Classes  ?

  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • A61K 31/465 - NicotineDerivatives thereof
  • A61P 25/34 - Tobacco-abuse