A wastewater treatment device and a method for treating wastewater by adopting the device. The device is used for treating high-concentration, high-salinity wastewater by using an ozone-three-dimensional electrode coupling technique, and comprises an ozone generating device (1), a three-dimensional electrode reactor (2) and a direct-current stable voltage power supply (9). Using the device, ozone aeration is carried out near a cathode (4) of the three-dimensional electrode reactor (2), and in this way, not only can oxidation be carried out by ozone, oxygen in the ozonized air can also react at the cathode to generate hydrogen peroxide generating a synergistic effect with ozone to further improve a degradation effect. Wastewater is rapidly oxidized and degraded into micromolecule organic matter, which can be biochemically treated, under the effect of H2O2 and hydroxyl free radicals with extremely strong oxidizing properties produced in an electrolytic process.
A trifluoromethyl-modified (+)-Patulolide C. By adding a trifluoromethyl group to (+)-Patulolide C, it is expected that favorable antibacterial and anti-inflammatory activity can be obtained.
A three-dimensional electrode filler comprises the following components in percentages by mass: 10% to 25% of improved slag, 35% to 50% of active charcoal, and 30% to 45% of mixed clay; wherein the mixed clay consists of kaolin accounting for 85% to 95% thereof and bentonite accounting for 5% to 15% thereof. A method of manufacturing a three-dimensional electrode filler comprises: performing an activation process, a copper plating process, and a nickel plating process on iron slag to obtain improved slag, wherein the activation process includes removing oil and rust; uniformly mixing the improved slag after performing the nickel plating process, active charcoal powder, and mixed clay according to defined proportions to produce a granular filler having a diameter of 5 to 10 mm; drying, and roasting the same for 2 h in an oxygen-free environment at 600°C; and cooling the same to obtain the three-dimensional electrode filler.
A nanocomposite catalyst for non-homogeneous catalytic ozonation, and a preparation method for the nanocomposite catalyst. The catalyst is an Ni-ZrO2 nanocomposite catalyst. A sol-gel method is first used to prepare a ZrO2 carrier, and an equal volume impregnation method is then used to prepare the Ni-ZrO2 nanocomposite catalyst.
Provided in the present invention is a method for preparing an L-2-aminobutyric acid through biocatalysis, comprising the following steps: constructing a genetically engineered bacteria for simultaneously expressing an FDH and an LDH to obtain a crude enzyme solution containing the FDH and the LDH through fermentation; and performing a biocatalytic reaction in a buffer solution to obtain the L-2-aminobutyric acid. The reaction system comprises a threonine, an ammonium formate, a TD enzyme solution, the FDH/LDH crude enzyme solution, a NAD+ and a pyridoxal phosphate.
Provided is a coenzyme regeneration system, comprising: a formate dehydrogenase (FDH), a leucine dehydrogenase (LDH) and an ammonium formate. Also provided is a method for preparing the coenzyme regeneration system, comprising the steps of: (1) heterogeneous expression of the formate dehydrogenase and the leucine dehydrogenase; and (2) preparation of the coenzyme regeneration system.
C12P 1/00 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes
7.
METHOD FOR RECYCLING CHIRAL 1-BENZYL-3-HYDROXYPIPERIDINE BY RACEMIZATION
The present invention relates to a method for recycling chiral 1-benzyl-3-hydroxypiperidine by racemization, which particularly comprises using resolution-recycled chiral N-benzyl-3-hydroxypiperidine (I) as a raw material, and recycling by racemization under the effect of a strong base to obtain N-benzyl-3-hydroxypiperidine. The recycling scheme by racemization has not been reported in literature, has a simple reaction, and is suitable for mass industrial production.
Disclosed is a dabigatran etexilate intermediate preparation method, the method comprising: a) utilizing 3-amino-4-methylaminobenzoic acid as a raw material for cyclization with chloroacetyl chloride to obtain 2-chloromethyl-1-methyl-1H-benzimidazole-5-carboxylic acid; b) the 2-chloromethyl-1-methyl-1H-benzimidazole-5-carboxylic acid is formed into 2-chloromethyl-1-methyl-1H-benzimidazole-5formyl chloride under the effect of oxalyl chloride; c) the 2-chloromethyl-1-methyl-1H-benzimidazole-5-formyl is condensed with 3-(pyridine-2-yl)aminopropanoic acid ethyl ester to obtain the N-(2-chloromethyl-1-methyl-1H-benzimidazole-5-acyl)-N-(pyridine-2-yl) -3-aminopropanoic acid ethyl ester. The synthetic route is not reported in any literature, and the raw material is cheap and easily available; in addition, the present invention has a simple unit operation and low equipment requirements, and is suitable for industrial mass production.
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Disclosed is an N-substituted phenyl glycine (dabigatran etexilate intermediate) preparation method unreported in any document, the method comprising: utilizing cheap and easily available substituted aniline (1) as raw material to condense with glyoxylic acid to form an imine, while conducting hydrogenation reduction to obtain N-(substituted phenyl) glycine. The synthetic route is not reported in any document, and the raw material is cheap and easily available; in addition, the present invention has simple unit operation and low device requirement, and is suitable for large-scale industrial production.
C07C 255/58 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
C07C 253/30 - Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
C07D 271/07 - 1,2,4-OxadiazolesHydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
10.
METHOD OF PREPARATION AND CHIRAL INVERSION OF CHIRAL-1-T-BUTOXYCARBONYL-3-HYDROXY PIPERIDINE
The present invention relates to a method of preparation and chiral inversion of chiral-1-t-butoxycarbonyl-3-hydroxy piperidine, the method mainly comprising the steps of: using N-benzyl-3-hydroxy piperidine as raw material, and splitting to obtain (S) or (R)-1-benzyl-3-hydroxy piperidine camsylate; dissociating by a base to obtain (S) or (R)-1-benzyl-3-hydroxy piperidine; conducting hydrogenating debenzylation/t-butoxycarbonyl protection by palladium-charcoal to obtain (S) or (R)-1-t-butoxycarbonyl-3-hydroxy piperidine. Using (R) or (S)-1-substituted-3-hydroxy piperidine as raw material, and acylating the substituted sulfonyl chloride to obtain (R) or (S)-1-substituted-3-hydroxy piperidine sulfonic ester; substituting in substitute carboxylates to obtain (S) or (R)-1-substituted-3-hydroxy piperidine carboxylic ester; hydrolyzing by base to obtain (S) or (R)-1-substituted-3-hydroxy piperidine. The synthesis route has mild reaction conditions, and is suitable for industrial mass production.
Disclosed is a 2-substituted-2H-1,2,3-triazole derivative, a compound as represented by formula I or II. Also disclosed is a preparation method of the compound as represented by formula I or II, in particular to a preparation method of 2-substituted-4-bromo-5-chloro-1H-1,2,3-triazole, 2-substituted-4-bromo-5-iodo-1H-1,2,3-triazole, and 2-substituted-5-chloro-1H-1,2,3-triazole-4-carboxylic acid. The preparation methods of the present invention are simple and feasible, and has high yield of the obtained compounds.
C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
12.
3-FLUOROALKYL-1-SUBSTITUTED PYRAZOL-4-CARBOXYLIC ACID AND PREPARATION METHOD THEREFOR
Provided are 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid and a preparation method therefor. The method includes performing a hydrogenation reaction to remove chlorine by using a derivative of 3-fluoroalkyl-5-chloro-1-substituted pyrazol-4-carboxylic acid as the raw material under the action of palladium-carbon or Raney nickel, and under the action of a base and in an atmosphere of hydrogen, so as to obtain the 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid. The above-mentioned preparation method has cheap and readily available raw materials, simple operation of the preparation process and low equipment requirements, and is suitable for industrial mass production.
C07D 231/14 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
13.
METHOD OF PREPARING AND RECOVERING 2-METHYL-5-IODOBENZOIC ACID
Provided is a method of preparing and recovering 2-methyl-5-iodobenzoic acid. The method utilizes o-methylbenzoic acid as raw material, iodinating via iodine/potassium persulfate in a mixed acid solvent to obtain a mixture of 2-methyl-5-iodobenzoic acid, 2-methyl-3-iodobenzoic acid, and 2-methyl-3, 5-diiodobenzoic acid; refining to obtain 2-methyl-5-iodobenzoic acid and recoverable mother liquor , the recoverable mother liquor being a mixture of 2-methyl-5-iodobenzoic acid, 2-methyl-3-iodobenzoic acid, and 2-methyl-3, 5-diiodobenzoic acid; conducting catalytic hydrogenation and deiodination to recover o-methylbenzoic acid and iodide ions; and oxidating the iodide ions to recover iodine. The whole process is recycled. The preparation and recovery method has cheap and easily available raw materials, and is easy of operation, has low requirements for equipment, and is suitable for large-scale industrial production.
C07C 51/363 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogenPreparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by substitution of halogen atoms by other halogen atoms
14.
3-FLUOROALKYL-1-SUBSTITUTED PYRAZOLE-4-CARBOXYLIC ACID AND THE PREPARATION METHOD THEREFOR
Provided are 3-fluoroalkyl-1-substituted pyrazole-4-carboxylic acid and a preparation method therefor. In the method, a fluoroacetic acid derivative, as a starting material, is condensed with an acetamide derivative to form a fluoroacetoacetamide derivative, followed by reacting with an orthoformate to form a 2-alkoxymethylenefluoroacylacetamide derivative, and then reacting with a hydrazine reagent to obtain a 1-substituted-3-fluoroalkylpyrazole-4-amide derivative, which is hydrolysed to obtain 3-fluoroalkyl-1-substituted pyrazole-4-carboxylic acid. The method uses cheap and easily available starting materials, is simple to operate, has low equipment requirements, and is suitable for large-scale industrial production.
C07D 231/14 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
15.
1-SUBSTITUTED-5-CHLORO-2H-1,2,3-TRIAZOLE-4-CARBOXYLATE DERIVATIVE AND PREPARATION METHOD THEREFOR
Dislcosed are a 1-substituted-5-chloro-2H-1,2,3-triazole-4-carboxylate derivative and a preparation method therefor. The disclosed 1-substituted-5-chloro-2H-1,2,3-triazole-4-carboxylate derivative has a structure as represented by formula (I), where R expresses either an alkyl, an aryl, an aralkyl, a cycloalkyl, a cycloalkylalkyl, a heteroaryl, a heteroarylalkyl or a heterocycloalkyl. The preparation method of the present invention is simple and easy, and acquires a high compound yield.
Disclosed are a 1-substituted-4-bromo-2H-1,2,3-triazole derivative and a preparation method therefor. The disclosed 1-substituted-4-bromo-2H-1,2,3-triazole derivative has a structure as represented by formula (I), where R expresses either an alkyl, an aryl, an aralkyl, a cycloalkyl, a cycloalkylalkyl, a heteroaryl, a heteroarylalkyl or a heterocycloalkyl, and X expresses either chlorine or iodine. The preparation method of the present invention is simple and easy, and acquires a high compound yield.
Disclosed is a 2-substituted-2H-1, 2, 3-triazole derivative, a compound as represented by formula I or II. Also disclosed is a preparation method of the compound as represented by formula I or II, in particular to a preparation method of 2-substituted-4-bromo-5-chloro-1H-1, 2, 3-triazole, 2-substituted- 4-bromo-5-iodo-1H-1, 2, 3-triazole, and 2-substituted-5-chloro-1H-1, 2, 3-triazole-4-carboxylic acid. The preparation methods of the present invention are simple and feasible, and has high yield of the obtained compounds.
C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
18.
Method for preparing 2-(N-substituted)-amino-benzimidazole derivatives
A method for preparing 2-(N-substituted)-amino-benzimidazole derivatives is provided, which comprises the following steps: (1) reacting a compound of 2-(N-protecting group)-O-aryl diamine with a compound of N-phenoxycarbonyl monosubstituted amine to obtain a compound of 2-(N-protecting group)-amino aryl urea; (2) in a suitable organic solvent, performing dehydrating cyclization reaction of the compound of 2-(N-protecting group)-amino aryl urea in the presence of an organic base and dichloro triphenylphosphine prepared by triphenylphosphine oxide with oxalyl chloride or diphosgene or triphosgene, or dibromo triphenylphosphine prepared by triphenylphosphine oxide with bromine, to produce a compound of 1-protecting group-2-(N-substituted)-amino-benzimidazole; (3) deprotecting the resulting compound of 1-protecting group-2-(N-substituted)-amino-benzimidazole to obtain the compound 2-(N-substituted)-amino-benzimidazole.
C07D 235/30 - Nitrogen atoms not forming part of a nitro radical
C07C 303/40 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
C07D 235/14 - Radicals substituted by nitrogen atoms
19.
PREPARATION METHOD FOR 1-SUBSTITUTED-4-BROMINE-1H-1,2,3-TRIAZOLE-5-CARBOXYLIC ACID
A preparation method for 1-substituted-4-bromine-1H-1,2,3-triazole-5-carboxylic acid. The method uses 4,5-dibromo-2H-1,2,3-triazole as the raw material, and then 1-substituted-4-bromine-1H-1,2,3-triazole-5-carboxylic acid is obtained after reaction for many times.
Disclosed is a preparation method of high-optical purity N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine. The method includes: adding crude N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine to one or more organic solvents, and then reacting with an organic acid to form a salt, which is precipitated, thereby achieving the purpose of separation and purification; next, adding the obtained solid or mother concentrate into deionized water, and then adding an inorganic base or an organic base for basification, so as to adjust the pH value, removing the organic acid, filtering, washing and drying, to obtain the high-optical purity N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine, where the molar ratio of 1S-isomer to 1R-isomer is equal to or greater than 99:1.
Disclosed is a method for preparing the compound of 2, 4-di-substituted-2H-1, 2, 3-triazole derivative, in particular to a method for preparing the compounds of 2-substituted-2H-1, 2, 3-triazole-4-carboxylic acid and 2-substituted-2H-1, 2, 3-triazole-4-boric acid.
Preparation methods of 2-(N-substituted)-amino-benzimidazole derivatives are disclosed, compring such steps: (1) reacting 2-(N-protecting group)-benzene-1,2-diamines with N- phenoxycarbonylamines to obtain 2-(N-substituted)-amino-aryl ureas; (2) in sutable solvent, reacting 2-(N-substituted)-amino-aryl ureas with triphenyldichlorophosphorane or triphenyldibromophosphorane that is obtained by triphenyl phosphorus oxide and oxalyl chloride or diphosgene or triphosgene, or by triphenyl phosphorus oxide and bromine, and in the presence of organic base cyclization to give the compound of 1-protecting group-2-(N-substituted)-aminobenzimidazoles; (3) deprotection of 1-protecting group-2-(N-substituted)-aminobenzimidazoles to obtain 2-(N-substituted)-amino-benzimidazole. Present methods have simple operation, high yields, and reduced costs.
C07D 235/14 - Radicals substituted by nitrogen atoms
C07C 275/28 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
C07C 273/18 - Preparation of urea or its derivatives, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
24.
METHOD FOR PREPARING N2-[1-(S)-ETHOXYCARBONYL-3-PHENYLPROPYL]-N6- TRIFLUOROACETYL-L-LYSINE WITH HIGH OPTICAL PURITY
A method for preparing N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl -L-lysine is provided. The method comprises: adding crude N2-[1-(S)-ethoxy carbonyl-3-phenyl-propyl]-N6-trifluoroacetyl-L-lysine to an organic solvent, adding an organic acid, stirring, filtering, and then adding to deionized water, adding an inorganic base or organic base to adjust pH, filtering, washing and drying to obtain N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine product with high optical purity. With the method, the prepared product has high optical purity and 1S-isomer/1R-isomer is ≥99/1.
C07C 233/47 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C07C 231/20 - Preparation of optical isomers by separation of optical isomers
patents
