A61B 17/00 - Surgical instruments, devices or methods
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
The present invention provides a technique simulator with which it is possible to experience that a pressure difference is generated by blocking a blood vessel using a balloon and it is possible to selectively administer a therapeutic agent to a specific region. A technique simulator (10A) comprises a flow path (12) including a liquid (L) that imitates blood, a liquid flow generation member for adding a flow to the liquid (L), and a catheter insertion port (14). The flow path (12) has a first branched flow path (24) and a second branched flow path (26) downstream of a branching unit (22). The technique simulator (10A) furthermore includes a pressure difference generation member for generating a pressure difference between the downstream side of the first branched flow path (24) and the downstream side of the second branched flow path (26). The liquid flow generation member generates pressure higher than the pressures applied to the downstream side of the first branched flow path (24) and the downstream side of the second branched flow path (26).
Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
[Problem] To provide a hemostatic instrument in which the strength of an expansion part can be satisfactorily maintained, and with which the discharge rate of a gas can be easily adjusted. [Solution] A hemostatic instrument 10 comprising a band 20 for being wrapped around the wrist W, a fixing means 30 that fixes the band when the band has been wrapped around the wrist, an expansion part 40 that is connected to the band and that expands by gas being injected thereinto, and a filter member 70 that controls the discharge of the gas that has been injected into the expansion part, wherein the band has at least one hole part 24 that penetrates between the inner surface and the outer surface of the band, the expansion part is disposed so as to cover the hole part at the inner surface of the band, and the filter member is disposed on the band so as to block the hole part and inhibits the discharge of gas from the hole part.
In a method for assessing pain caused by the administration of a drug solution, a rat (12) is provided, the rat (12) is anesthetized by inhalation anesthesia, a measurement electrode (24) is placed in the semitendinosus muscle (12b) of the anesthetized rat (12), an injection needle (18) is punctured under the plantar skin surface (12a) of the anesthetized rat (12) while measuring the muscle potential in the semitendinosus muscle (12b) with the measurement electrode (24), a drug solution is administered to the anesthetized rat (12) through the injection needle (18) after a myoelectric reaction caused by the punctuation of the injection needle (18) disappears, and at least one of the measurement of the duration time (T) of the myoelectric reaction caused by the administration of the drug solution and the measurement of the EMG intensity, which is produced by integrating absolute values of muscle potentials during the period between the onset of the myoelectric reaction by the administration of the drug solution to the disappearance of the myoelectric reaction, is carried out.
The present invention relates to an adjuvant composition comprising a pH-sensitive carrier and an aluminum-containing substance. According to the present invention, an adjuvant can be provided, which is highly safe and can induce cell-mediated immunity effectively through cross-presentation.
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A method of treating peripheral artery diseases in lower limbs by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystals are transferred to the blood vessel wall, and deflating the expandable member such that a pharmacokinetics profile is presented in which a drug concentration in the blood vessels is kept for the inhibition of smooth muscle cell proliferation in a high drug-concentration period of time, and for the non-inhibition of endothelial cell growth in a later low drug-concentration period of time.
Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The polymer particle is the reaction product of at least one monomer including at least one functional group; and at least one crosslinker; wherein the polymer particle has a diameter between about 40 1.1.m and about 1,200 1.1.m and is susceptible to degradation through hydrolysis or enzymatic action. The particle embolics can be used as embolization agents.
C08F 290/00 - Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
C08G 63/91 - Polymers modified by chemical after-treatment
C08G 69/48 - Polymers modified by chemical after-treatment
The purpose of the present invention is to provide a drug coating layer for which toxicity is low and stenosis inhibition rate is high when a drug is coated on a medical instrument and delivered into a body, and a medical instrument using same. Provided is a drug coating layer having a morphological form comprising multiple long crystals of a water-insoluble drug, each crystal of which has an independent long axis, on a substrate surface. The long axes of the long crystals are substantially linear and the long axes of the long crystals intersect with the plane of the substrate to form angles in a specified range.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
There is provided a drug coating layer which is expected to have low toxicity and a high intravascular stenosis inhibitory effect, when delivering a medical device coated with a drug into the body. There is also provided a medical device using the drug coating layer and method for delivering it. The drug coating layer is a drug coating layer having a morphological form of a water-insoluble drug and crystalline particles of the water-insoluble drug configured to be arranged with regularity in the substrate surface . Excipient particles having an excipient are configured to be irregularly arranged between the crystalline particles . A molecular weight of the excipient is less than a molecular weight of the water-insoluble drug, a ratio occupied by the excipient particles per a predetermined area of a substrate is less than a ratio occupied by the crystalline particles, and the excipient particles do not form a matrix.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
Provided is a syringe storage container configured so that a syringe can be extracted without raising a syringe holding section. A syringe storage container (1) is provided with a syringe (10), a cap (30), a syringe holding section (40), and a container body (50). The syringe (10) has a discharge section (12), a flange section (16), and a side peripheral section (11) which continues to both the discharge section (12) and the flange section (16). The cap (30) is mounted to the discharge section (12) and has an outer radius (R2) greater than the outer radius (R1) of the side peripheral section (11). The container body (50) has an opening (53) at the upper part thereof and is formed in a square box-like shape. The syringe holding section (40) is placed within the container body (50), has a through-hole (43) for allowing the syringe (10) to be inserted therein in the vertical direction, and holds the syringe (10) inserted in the through-hole (43). An inner peripheral surface (44) which forms the through-hole (43) is formed in such a manner that the radius of the upper end of the inner peripheral surface (44) is greater than the outer radius (R2) of the cap (30) and in such a manner that the radius (R4) of the lower end of the inner peripheral surface (44) is greater than the radius of the upper end thereof. The inner peripheral surface (44) has a tapered section (45) having a diameter reducing as the tapered section (45) extends upward from the lower end.
PH-SENSITIVE CARRIER AND PREPARATION METHOD THEREOF, AND PH SENSITIVE DRUG AND PH SENSITIVE DRUG COMPOSITION EACH CONTAINING THE CARRIER, AND CULTURE METHOD USING THE SAME
Provided are: a pH-sensitive carrier for a physiologically active substance, which can respond to a weakly acidic environment to promote a membrane-disrupting function; a method for producing the carrier; a pH-sensitive medicine and a pH-sensitive pharmaceutical composition, each containing the carrier; and a corresponding culture method. A pH-sensitive carrier which can exhibit an effect of promoting a membrane-disrupting function, comprising: at least one pH-sensitive compound selected from the group consisting of deoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, a higher bile acid, glycodeoxycholic acid, glycyrrhizic acid, glycyrrhetinic acid and salts thereof; and at least one amphipathic substance selected from the group consisting of a phosphatidylcholine having 10 to 12 carbon atoms, a polyoxyethylene sorbitan mono-fatty acid ester having 12 to 18 carbon atoms, a sorbitan fatty acid ester having 16 to 18 carbon atoms, glycerol monooleate, glycerol dilaurate, glycerol distearate, glycerol d'oleate, polyoxyethylene castor oil and u-tocopherol.
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
C07K 17/02 - Peptides being immobilised on, or in, an organic carrier
15.
COATING COMPOSITION FOR A DRUG-ELUTING STENT OR CATHETER
The present invention provides a coating composition for drug eluting medical devices, which enables a medical device to be delivered to a target tissue without having a medical agent easily separated from the medical device on the way to the target tissue for the purpose of treating an affected blood vessel such as restenosis. This coating composition for drug eluting medical devices contains a water-insoluble medical agent and at least one substance that is selected from the group consisting of ester compounds of amino acids, which have a hydrophobicity index of an amino acid side chain of 0 or less, and salts thereof.
The aim of the present invention lies in providing a catheter balloon (11) which has improved pressure resistance in a film as a whole, and a balloon catheter (10). A tubular catheter balloon (11) is formed from a film comprising a lamination of at least two layers comprising a polyamide elastomer layer (8) and a polyamide layer (9). The polyamide elastomer layer (8) is provided inside the polyamide layer (9). The refractive index nr1 in the circumferential direction of the section perpendicular to the axis on the inside surface of the polyamide layer (9) is greater than the refractive index nr2 in the circumferential direction of the section perpendicular to the axis on the inside surface of the polyamide elastomer layer (8), and the difference between the refractive index nr1 and the refractive index nr2 is at least 0.01.
Provided is a catheter assembly (1) equipped with: a hollow catheter (2); a catheter hub (3), fixed onto the base end of the catheter (2), internally having a passage (31) communicating to the inside of the catheter (2); a needle (4) which is inserted into the catheter (2); and a needle hub (5), fixed onto the base end of the needle (4), capable of being connected with the base end side of the catheter hub (3). This catheter assembly (1) has: a valve element (7), having an opening and closing unit (71) capable of opening and closing, positioned to choke the passage (31); an operating member (8) having a tubular body, arranged so that one opening (85) is inserted into the opening and closing unit (71) to communicate the base end and the tip of the catheter hub (3); and a communicating unit (9), arranged on the inner perimeter of the catheter hub (3) equipped with the valve element (7), which communicates the base end and the tip. In this catheter assembly (1), a sealing member (10) having a tubular body, which allows the passage of air yet blocks the passage of liquids, is arranged between the valve element (7) and the operating member (8), as to close the communication unit (9).
The present invention addresses the problem of providing a safety needle assembly having a high level of both safety and operability. The present invention is a safety needle assembly (100) having a hub (1), a cannula (2), a collar (3), a protector (4), and a sheath (5). The sheath (5) is provided with: an opening for accommodating the cannula (2); a cannula fixing part for fixing the cannula (2) accommodated in the opening; a mounting part for rotatably supporting the sheath (5), the mounting part being mounted on the hub (1) or the collar (3); and a protruding stopper for the finger of a user for pressing on the sheath (5) in order to accommodate the cannula (2) in the opening of the sheath (5), the protruding stopper being provided in the center vicinity in the length direction on the opposite side from the opening surface of the opening, or in a more distal end-side position of the sheath (5).
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
19.
INJECTION NEEDLE ASSEMBLY AND DRUG INJECTION DEVICE
Provided are an injection needle assembly and drug injection device which reduce the amount of drug residue as a result of a structure which does not require precise adjustment of the position of the base end of a needle tube with respect to a needle hub. An injection needle assembly (2) comprises a needle tube (5) which has a needle tip (5A) for puncturing the skin, a needle hub (6), and an elastic member (7). The needle hub (6) comprises a first member (11) for holding the needle tube (5), and a second member (12) for insertion of an evacuation part (52) of a syringe (3). The elastic member (7) is disposed inside the second member (12) and adheres in a liquid-tight manner to the inside surface of the second member, and the elastic member (7) has a through hole (45) through which the needle tube (5) is allowed to pass.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
Provided is a stent such that there is minimal occurrence of strain or of stress concentration in a drug coated layer as a consequence of expansion and deformation of the stent in the radial direction thereof, and that as a result, there is no risk of the drug falling off. The aforementioned stent is characterized in that the thickness (B) of the drug coated layer (4) formed by coating the outer surface of a stent body (2) gradually decreases toward a bending section (K), that reduction is made to the strain and stress which occur in the drug coated layer (4) as a consequence of expansion and deformation of the stent (1), and that as a result, the drug is prevented from falling off.
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Provided is a guide wire, which comprises a lengthy wire body, and a marker disposed in at least the tip side portion of the wire body all over the circumference and having a function to indicate the position of the wire body in a living body. The marker is formed into a lattice shape as a whole by causing a first filament portion and a second filament portion to intersect with each other at a plurality of portions. Moreover, the intersecting portions of the first filament portion and the second filament portion are formed in plurality in the marker. Noting a predetermined one of those intersecting portions, therefore, the predetermined intersecting portion looks, as if it moves radially of the guide wire, when the guide wire is turned on its axis. Thus, it is possible to confirm reliably that the guide wire has been turned.
A tube connecting apparatus that can carry out self reset operation without giving damage to the apparatus and that safety of an operator is considered. The tube connecting apparatus has an EEPROM memorizing information with respect to a connecting process state of tubes. When electric power is inputted, the apparatus judges whether power supply was shut off during tube connecting operation based upon the information memorized in the EEPROM with respect to the connecting process state of tubes and a detecting result of a wafer 41 according to a wafer position detecting sensor 421, and carries out reset operation. In the reset operation, the apparatus restarts and completes connecting operation (S620 to 632) by heating the wafer again to fuse the tubes adhered to the wafer (S614, 616) . Error indication is displayed at a LCD display to secure connecting strength and the like (S634). A locking state is not cancelled during cooling time after heating of the wafer is stopped to secure safety (S628 to S632).
B29C 65/20 - Joining of preformed partsApparatus therefor by heating, with or without pressure using heated tool with direct contact, e.g. using "mirror"
A tube clamp apparatus and a tube connecting apparatus having high durability and improved operability when an operator locks these apparatuses are provided. A tube connecting apparatus comprises a first clamp and a second clamp, each pressing to hold two flexible tubes 8, 9. The tubes are placed at a lower jaw portion of the second clamp and pressed to a flat state by pressing force applied thereto a direction of an arrow F. A hook section 310 having hook portions divided into plural pieces is set up at an upper jaw portion of the second clamp, and the hook portion B 312 is made of a POM elastic member having, on one side thereof, a protruded portion 314 protruded from other adjacent hook portions. When pressing force is applied to the upper jaw portion, the hook portion B 312 protruded from the other adjacent hook portions is elastically deformed and engaged with a POM-made roller B 317 to prevent back-tracking of the hook section 310.
B29C 65/20 - Joining of preformed partsApparatus therefor by heating, with or without pressure using heated tool with direct contact, e.g. using "mirror"
B29C 65/74 - Joining of preformed partsApparatus therefor by welding and severing
B29C 65/78 - Means for handling the parts to be joined, e.g. for making containers or hollow articles
patents
