Disclosed are methods for that can be effective for treating a Mycobacterium infection in a biological organism, in particular in humans, involve administering a medicinal formulation that includes specific bioactive compounds with N-acetylglucosamine or N-glycolylglucosamine and triazole. The compound interacts with the Mycobacterium to provide treatment. The method can be applied without detrimental toxicity to human subjects and is particularly relevant for tuberculosis infections. The formulation can be administered in various ways, including orally and intravenously, and may be provided in a dosage of, for example, about 0.5-100 mg/kg of body weight. Additionally, the method may include steps for diagnosing and monitoring the treatment of the infection.
A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
A61P 31/06 - Antibacterial agents for tuberculosis
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
41 - Education, entertainment, sporting and cultural services
Goods & Services
Career counseling, namely, providing advice concerning education options to pursue career opportunities; educational services, namely, holding workshops in the field of job interviewing and networking and providing related materials; Career counseling, namely, providing advice concerning education options to pursue career opportunities for alumni and graduating students; Education services, namely, providing courses at the university level
This invention is directed to compounds of Formula (I)
pharmaceutically acceptable salts, esters, and prodrugs thereof, to their preparation, to pharmaceutical compositions comprising compounds of Formula I, and to their uses as antimicrobial agents.
C07C 233/92 - Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with at least one carbon atom of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 31/4465 - Non-condensed piperidines, e.g. piperocaine only substituted in position 4
C07D 211/34 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
4.
NOVEL ANTIBACTERIAL COMPOUNDS AND METHODS OF MAKING AND USING SAME
The invention provides novel antibacterial diamide compounds, pharmaceutical compositions comprising the compounds and methods for treating or preventing an infection in a subject using the compounds.
A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
5.
Antibacterial compounds and methods of making and using same
The invention provides novel antibacterial diamide compounds, pharmaceutical compositions comprising the compounds and methods for treating or preventing an infection in a subject using the compounds.
C07C 237/14 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
The invention provides novel antibacterial diamide compounds, pharmaceutical compositions comprising the compounds and methods for treating or preventing an infection in a subject using the compounds.
