The present disclosure relates to process for preparing a semi-permeable membrane comprising a porous support membrane and a thin film composite (TFC) layer, comprising providing an aqueous phase comprising a polyfunctional amine monomer, covering a surface of a porous support membrane with the aqueous phase, providing an organic phase comprising a poly functional acy 1 halide monomer and a pore forming agent, covering the aqueous phase with the organic phase and allowing the polyfunctional amine monomer. the polyfunctional acyl halide monomer, and the pore forming agent to perform an interfacial polymerization reaction to form a polyamide TFC layer. The present disclosure further relates to a membrane for water filtration, in particular a membrane for performing forward osmosis (FO), reverse osmosis (RO), or pressure assisted forward osmosis (PAFO), the membrane comprising a polyamide TFC layer.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
The disclosure relates to a vesicle in a liquid composition, the vesicle including plant-derived transmembrane proteins. The disclosed embodiments further relate to methods of producing the vesicles and separation membranes of such vesicles. The present disclosure provides for the preparation of a separation membrane using vesicle components originating exclusively or mainly from natural sources.
A process for preparing a semi-permeable membrane includes providing an aqueous phase comprising a polyfunctional amine monomer, covering a surface of a porous support membrane with the aqueous phase, applying an organic phase comprising a polyfunctional acyl halide monomer, a phosphorous containing compound and a co-solvent, and allowing the polyfunctional amine monomer and the polyfunctional acyl halide monomer to perform an interfacial polymerization reaction to form a polyamide thin film composite layer.
The presence of the co-solvent together with the phosphorous compound in the organic phase potentiates the effect of the phosphorous compound so that the water flux is increased without substantially sacrificing the salt rejection.
A process for preparing a hollow fiber includes the steps of providing a dope solution including polyamide imide (PAI), providing an aqueous bore solution including polyethylene imine (PEI), extruding the dope solution in an cross-sectional annular shape and ejecting the bore solution in the center of the annular shape, allowing the PAI and the PEI to react, thereby forming an internal surface layer including the cross-linked reaction product, and forming a polyamide Thin Film Composite (TFC) layer by interfacial reaction of aqueous di- or triamine compound and organic di- or triacylhalide compound on the internal surface layer including the cross-linked reaction product.
The present disclosure relates to a method of preparing a thin film composite layer immobilizing vesicles incorporating a transmembrane protein on a porous substrate membrane, comprising providing an aqueous solution comprising the vesicles and a di-amine or tri-amine compound, covering the surface of a porous support membrane with the aqueous solution, applying a hydrophobic solution comprising an acyl halide compound, and allowing the aqueous solution and the hydrophobic solution to perform an interfacial polymerization reaction to form the thin film composite layer.
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
The present disclosure relates to a method of preparing a thin film composite layer immobilizing vesicles incorporating a transmembrane protein on a porous substrate membrane, comprising providing an aqueous solution comprising the vesicles and a di-amine or tri-amine compound, covering the surface of a porous support membrane with the aqueous solution, applying a hydrophobic solution comprising an acyl halide compound, and allowing the aqueous solution and the hydrophobic solution to perform an interfacial polymerization reaction to form the thin film composite layer.
The present invention relates to an anti-fouling, semi-permeable membrane comprising a porous support layer, a thin film composite (TFC) layer formed on a surface of the support layer, and a cross-linked polyvinyl alcohol (PVA) layer formed on top of the TFC layer, wherein the cross-linked PVA layer is the reaction product of PVA and a cross-linking agent, said cross-linking agent being a polybasic acid comprising three or more acid groups or precursors thereof. The obtained membrane shows a high water flux and a low roughness suitable for an effective membrane notable for feed solution having a tendency of fouling the membrane.
B01D 65/08 - Prevention of membrane fouling or of concentration polarisation
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
A concentrated spent dialysate is produced for by reducing electrolytes in a spent dialysate by electrodialysis and de-watering the spent dialysate by a forward osmosis operation.
A concentrated spent dialysate is produced for by reducing electrolytes in a spent dialysate by electrodialysis and de-watering the spent dialysate by a forward osmosis operation.
A hemodialysis treatment apparatus has an ultrafiltration unit for exchange of solutes of a patient's blood plasma and a dialysate, resulting in a stream of cleaned blood for returning to the patient and a stream of spent dialysate. An electrodialysis device reduces electrolytes in the spent dialysate. A forward osmosis unit with a membrane having a feed side and a draw side that is allows only water to permeate. A stream of spent dialysate from the ultrafiltration unit is in fluid communication with the feed side and a stream of concentrated dialysate is in fluid communication with the draw side. A stream of dialysate results. Blood plasma is pumped from the patient to the ultrafiltration unit.
A hollow fiber module includes hollow fiber cartridges. A port receives a second solution to be treated in a shell side volume and another port for discharging the treated second solution. A first end cap has an inlet for a first solution and a distributer for distributing the first solution to a first end of the hollow fiber cartridges. A second end cap has a collector for collecting the treated first solution from the second end of the hollow fiber cartridges and an outlet for the treated first solution. A first connector has an inlet for the second solution and a distributer for distributing the second solution to a port of the hollow fiber cartridges. A second connector has a collector for collecting the treated second solution from the other port of the hollow fiber cartridges and an outlet for the treated second solution.
The present disclosure relates to a method for enriching an aqueous ethanolic solution in ethanol, including the steps of providing a forward osmosis membrane module with a first chamber, a second chamber and a semi-permeable membrane separating the first and the second chamber, coupling an inlet of the first chamber fluidly to a source of an aqueous ethanolic solution, coupling an inlet of the second chamber fluidly to a source for a concentrated draw solution, and recovering an aqueous ethanolic solution enriched in ethanol at an outlet of the first chamber and a diluted draw solution at the outlet of the second chamber.
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
A process for the production of a membrane protein including the steps of: expressing a membrane protein in a host organism present in an aqueous medium, liberating the membrane protein from the host organism, adding a detergent solution to solubilize the membrane protein, recovering a liquid fraction of the solubilized membrane protein, subjecting the liquid fraction to chromatography to bind or retain the membrane protein on a stationary phase, and eluting the stationary phase with an elution buffer to produce the membrane protein. The process can produce relatively large amounts of membrane proteins in an efficient way without including the quality of the end product.
A vesicle incorporate a transmembrane protein, the vesicle forming material including a mixture of poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) and polyetheramine. The vesicle can generally withstand elevated temperature without substantial shrinkage of the diameter, which in turn results in maintenance of the water permeability virtually unaffected. Pluronic based vesicles have a large content of amino groups available on the surface illustrated by the larger zeta potential values available for crosslinking in the polyamide layer by chemical reaction with trimesoyl chloride (TMC).
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
The present invention relates to a water extraction system for up-concentration of organic solutes comprising a flow cell comprising a membrane; said membrane comprising an active layer comprising immobilized aquaporin water channels and a support layer, and said membrane having a feed side and a non-feed side; and an aqueous source solution in fluid communication with the feed side of the membrane. The system also includes an aqueous source solution in fluid communication with the feed side of the membrane and an aqueous draw solution in fluid communication with the draw side of the membrane. The aqueous source solution comprises the organic solutes. The membrane module comprises an inlet and an outlet for the aqueous draw solution. The aquaporin vesicles are formed by self-assembly of block copolymers in the presence of an aquaporin protein suspension.
B01D 71/74 - Natural macromolecular material or derivatives thereof
C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
The present invention relates to self-assembled nanostructures comprising polyalkyleneimine (PAI) and a detergent solubilized transmembrane protein, such as an aquaporin protein.
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
The present invention relates to systems, methods and uses for recycling at least a part of water lost during various renal replacement therapy processes, e.g. in the preparation of a fresh dialysate solution or fresh reconstitution fluid for kidney disease dialysis and hemofiltration by utilizing water from the spent fluids. The system of the invention is useful in hemodialysis and in peritoneal dialysis as well as in hemofiltration for reuse of water from filtrates and spent fluids. In addition, the system of the invention is useful in the development of a renal assist device or artificial kidney.
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
The present invention relates to a hollow fiber (HF) module having fibers modified with a thin film composite (TFC) layer comprising aquaporin water channels.
B01D 39/00 - Filtering material for liquid or gaseous fluids
B01D 39/14 - Other self-supporting filtering material
B01D 29/00 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 63/00 - Apparatus in general for separation processes using semi-permeable membranes
B01D 33/21 - Filters with filtering elements which move during the filtering operation with rotary plane filtering surfaces with hollow filtering discs transversely mounted on a hollow rotary shaft
B05D 5/00 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
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