PercuSense, Inc.

United States of America

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Date
2025 June 1
2025 May 1
2025 (YTD) 2
2024 9
2023 8
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IPC Class
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value 19
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase 14
A61B 5/00 - Measuring for diagnostic purposes Identification of persons 13
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter 9
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions 9
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Status
Pending 23
Registered / In Force 11

1.

Analyte Sensor

      
Application Number 18988687
Status Pending
Filing Date 2024-12-19
First Publication Date 2025-06-19
Owner PercuSense, Inc. (USA)
Inventor
  • Olczak, Kaitlynn
  • Morrow, Blake
  • Shah, Rajiv
  • Kannard, Brian
  • Liang, Bradley
  • Wolfe, Katherine
  • Espinoza, Elizabeth

Abstract

In one embodiment, a working electrode to detect the presence of an analyte is disclosed. The working electrode includes an electrical insulator having a well. The working further includes an electrical conductor that is positioned at the bottom of the well and a reactive chemistry that includes a dehydrogenase based enzyme and cofactor at least partially filling the well. Where the reactive chemistry has a minimum molecular weight and a hydrogel is located over the reactive chemistry. The hydrogel is in contact with the insulation and the reactive chemistry and the hydrogel has a porosity less than the minimum molecular weight of the reactive chemistry.

IPC Classes  ?

  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

2.

ANALYTE SENSOR

      
Application Number 19020322
Status Pending
Filing Date 2025-01-14
First Publication Date 2025-05-15
Owner PERCUSENSE (USA)
Inventor
  • Shah, Rajiv
  • Wolfe, Katherine
  • Liang, Bradley
  • Pendo, Shaun

Abstract

A sensor assembly is disclosed. The sensor assembly includes a piercing member with an interior and exterior. Also included within the sensor assembly is a sensor that is formed on a flexible substrate. The sensor includes a proximal end and a distal end where the distal end includes a flex that is terminated at a terminal end. The terminal end of the sensor being located within the interior of the piercing member.

IPC Classes  ?

  • A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value

3.

ANALYTE SENSOR

      
Application Number 17510131
Status Pending
Filing Date 2021-10-25
First Publication Date 2024-10-03
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley C.

Abstract

In one embodiment, A working electrode configured to detect exposure to a compound of interest is disclosed. The working electrode includes a substrate that is electrically conductive along with an electrode surface disposed on the substrate. The working electrode further includes a first transport material that is disposed over the electrode surface. The working electrode also includes a first reactive chemistry disposed substantially over the electrode surface, where the reactive chemistry reacts with a byproduct generated from the compound of interest. The reaction between the first reactive chemistry and the byproduct generates an intermediary that is electrochemically reduced on the electrode surface to generate an electrical signal that is representative of the presence of the byproduct, wherein detection of the compound of interest is determined by a decrease in the electrical signal.

IPC Classes  ?

4.

COMBINED SENSOR AND INFUSION SYSTEM

      
Application Number 18590847
Status Pending
Filing Date 2024-02-28
First Publication Date 2024-08-29
Owner PercuSense, Inc. (USA)
Inventor
  • Wolfe, Katherine
  • Nava, Bella
  • Pagliuso, Benjamin

Abstract

In one embodiment a system to monitor an analyte and dispense an infusate is disclosed. The system includes an on-body assembly with a first piece and a second piece. The first piece contains a sensor and a cannula and the cannula is in fluid communication with a first piece fluid channel. The second piece contains a pump mechanism connected to a second piece fluid channel. When the first piece is coupled to the second piece, the first piece fluid channel is placed in fluid communication with the second piece fluid channel to establish fluid transport from the pump mechanism through the cannula.

IPC Classes  ?

  • A61M 5/142 - Pressure infusion, e.g. using pumps
  • A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
  • A61M 5/158 - Needles
  • A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic

5.

STATE MACHINE CALIBRATION

      
Application Number 18395313
Status Pending
Filing Date 2023-12-22
First Publication Date 2024-08-22
Owner PercuSense, Inc. (USA)
Inventor Liang, Bradley

Abstract

In one embodiment an analyte monitoring system is disclosed. The system includes a body worn device having a housing that contains a processor, a memory, a power supply and a sensor interface. The system further includes an analyte sensor that is coupled to the sensor interface. The analyte sensor has a proximal portion contained within the housing that is interfaced with the sensor interface. The analyte sensor also has a distal portion configured to be inserted into a host when positioned outside the housing. The system also includes a finite state machine that selects from possible sensor calibration coefficients based on a current state of the analyte monitoring system, an initial input, and longitudinal inputs received from the analyte sensor. Wherein the processor generates calibrated sensor values based on the selected calibration coefficients and longitudinal inputs from the analyte sensor.

IPC Classes  ?

  • A61B 5/1495 - Calibrating or testing in vivo probes
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value

6.

SENSOR INSERTION

      
Application Number 18108500
Status Pending
Filing Date 2023-02-10
First Publication Date 2024-08-15
Owner PercuSense, Inc. (USA)
Inventor
  • Wolfe, Katherine
  • Pagliuso, Benjamin J
  • Nava, Bella T

Abstract

In one embodiment, an insertion assembly is disclosed that includes an electronics assembly. The electronics assembly includes a base and a housing and the housing has an enclosed portion and a mating portion. The insertion assembly further includes a sensor assembly that is detached from the electronics assembly. The sensor assembly includes a sensor and at least one mating feature. The sensor assembly is detachably coupled to a slider in a first position. The slider is coupled to an energy storage system. When the slider transitions to a second position, the sensor assembly is coupled to the electronics assembly to define an on-body assembly. The transition to the second position loads the energy storage system and upon actuation, the energy storage system is unloaded to transition the slider to the first position and the on-body assembly is positioned to decouple from the slider.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

7.

ANALYTE SENSOR

      
Application Number US2023080616
Publication Number 2024/155347
Status In Force
Filing Date 2023-11-20
Publication Date 2024-07-25
Owner PERCUSENSE, INC. (USA)
Inventor
  • Shah, Rajiv
  • Morrow, Blake
  • Kannard, Brian
  • Liang, Bradley
  • Olczak, Kaitlynn
  • Wolfe, Katherine

Abstract

An analyte sensor includes a working conductor having an electrode reactive surface. The analyte sensor further includes a first reactive chemistry being responsive to a first analyte and a first transport matrix that includes a first transport material and a mitigation compound. The first transport material enables flux of the first analyte to the first reactive chemistry. The analyte sensor includes a second transport material disposed over and configured to enable transport of a reactant to the first reactive chemistry. The first reactive chemistry does not contact the electrode reactive surface while at least partially overlapping a portion of the electrode reactive surface.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
  • G01N 27/327 - Biochemical electrodes

8.

MULTI-ANALYTE CONTINUOUS GLUCOSE MONITORING

      
Application Number 17679307
Status Pending
Filing Date 2022-02-24
First Publication Date 2024-02-22
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley C
  • Bowman, Ellen
  • Wolfe, Katherine

Abstract

A system to automatically detect at least one physiological state is disclosed. The system includes a single probe for insertion within a subject that has an analyte sensor array for continuous monitoring of at least glucose and a second analyte. The system further includes an electronics module that includes a power supply, a processor, memory and a bi-directional communications module. When the electronics module is coupled with the analyte sensor array the power supply delivers power to the analyte sensor array and the processor. The processor analyzing glucose and the second analyte data to detect a first physiological state from a plurality of physiological states.

IPC Classes  ?

  • A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

9.

ANALYTE SENSOR

      
Application Number 18230596
Status Pending
Filing Date 2023-08-04
First Publication Date 2024-02-08
Owner PercuSense, Inc. (USA)
Inventor Wolfe, Katherine

Abstract

In one embodiment, a sensor assembly is disclosed. The sensor assembly includes a first analyte sensor being formed on a first substrate and a second analyte sensor being formed on a second substrate. Wherein the first analyte sensor is coupled to the second analyte sensor within a coupling area defined by an overlap between the first analyte sensor and the second analyte sensor.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value

10.

Analyte sensor

      
Application Number 17871718
Grant Number 12350046
Status In Force
Filing Date 2022-07-22
First Publication Date 2024-01-25
Grant Date 2025-07-08
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley C
  • Wolfe, Katherine

Abstract

In one embodiment, a sensor is disclosed that includes a first conductive substrate coupled to, and electrically isolated from, a second conductive substrate. The sensor includes a first electrode trace within the first conductive substrate with a plurality of first working electrode openings. The sensor also includes a second electrode trace within the first conductive substrate with a plurality of second working electrode openings. Additionally a first transport material is included that covers the plurality of first working electrode openings and a second transport material that covers the plurality of second working electrode openings. A third transport material covers, and forms a barrier between the first and the second transport material. The sensor additionally includes a counter-reference electrode that is formed on the second conductive substrate.

IPC Classes  ?

  • G01N 27/327 - Biochemical electrodes
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • A61B 5/1495 - Calibrating or testing in vivo probes
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

11.

SENSOR INSERTION

      
Application Number 18371965
Status Pending
Filing Date 2023-09-22
First Publication Date 2024-01-11
Owner PercuSense, Inc. (USA)
Inventor
  • Wolfe, Katherine
  • Ferreira, Joseph
  • Messer, Ellen
  • Shah, Rajiv
  • Chan, Konrad

Abstract

An on-body insertion system is described. The on-body system includes a sensor in a first position being substantially parallel to an insertion surface. Activation of an actuator transitions the sensor to a second position. Wherein the transition imparts movement to the sensor that is substantially parallel to the insertion surface and the second position results in the sensing area being beneath the insertion surface.

IPC Classes  ?

  • A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

12.

ANALYTE SENSOR

      
Application Number 18136265
Status Pending
Filing Date 2023-04-18
First Publication Date 2023-11-09
Owner PercuSense, Inc. (USA)
Inventor
  • Olczak, Kaitlynn
  • Santos Cancel, Mirelis
  • Shah, Rajiv
  • Kannard, Brian
  • Liang, Bradley
  • Espinoza, Elizabeth

Abstract

In one embodiment, a sensor to measure the presence of an analyte is disclosed. The sensor includes a working conductor with an electrode reactive surface. The sensor further includes a first reactive chemistry that is responsive to a first analyte and is in direct contact with the electrode reactive surface. The first reactive chemistry includes an enzyme, a first transport material, and an entrappable cofactor that includes a cofactor for the enzyme coupled to an anchor molecule. The sensor further includes a second transport material that enables diffusion of the first analyte to the first reactive chemistry.

IPC Classes  ?

  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase

13.

CHEMWATCH

      
Serial Number 97931401
Status Pending
Filing Date 2023-05-11
Owner PercuSense, Inc. ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Medical instruments for use in non-invasive or implantable monitoring of analytes and physical states within tissue, vasculature, and bodily fluids for diagnostic and therapeutic applications in human and veterinary medicine

14.

PERCUSENSE

      
Serial Number 97931360
Status Pending
Filing Date 2023-05-11
Owner PercuSense, Inc. ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Medical instruments for use in non-invasive or implantable monitoring of analytes and physical states within tissue, vasculature, and bodily fluids for diagnostic and therapeutic applications in human and veterinary medicine

15.

ANALYTE SENSOR

      
Application Number 18083312
Status Pending
Filing Date 2022-12-16
First Publication Date 2023-04-20
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley C.
  • Wolfe, Katherine
  • Messer, Ellen
  • Pendo, Shaun

Abstract

An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

IPC Classes  ?

  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

16.

COMBINED INFUSION SET AND SENSOR

      
Application Number 18078784
Status Pending
Filing Date 2022-12-09
First Publication Date 2023-04-06
Owner PercuSense, Inc. (USA)
Inventor
  • Wolfe, Katherine
  • Shah, Rajiv

Abstract

In one embodiment, an infusion set and sensor assembly delivered within a subject is disclosed. The assembly includes a cannula that is terminated at a cannula opening. The assembly further includes a sharp that is at least partially within the hollow of the cannula. A sensor having a proximal end and a distal end is also included in the assembly. The proximal end of the sensor is held in a fixed location while the distal end is retained with a portion of the cannula. The sensor further includes sensor slack, wherein transitioning the sharp from a first position to a second position simultaneously inserts the cannula and sensor to a desired insertion depth within a subject via a single point of insertion.

IPC Classes  ?

  • A61M 5/46 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for controlling depth of insertion
  • A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
  • A61M 5/142 - Pressure infusion, e.g. using pumps

17.

GLYCEMICO

      
Serial Number 97856556
Status Pending
Filing Date 2023-03-24
Owner PercuSense, Inc. ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Medical instruments for use in non-invasive or implantable monitoring of glucose within tissue, vasculature, and body fluids for diagnostic and therapeutic applications in human and veterinary medicine

18.

Miscellaneous Design

      
Serial Number 97856530
Status Pending
Filing Date 2023-03-24
Owner PercuSense, Inc. ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Medical instruments for use in non-invasive or implantable monitoring of analytes and physical states within tissue, vasculature, and bodily fluids for diagnostic and therapeutic applications in human and veterinary medicine

19.

SYSTEM AND METHOD FOR DISEASE RISK ASSESSMENT AND TREATMENT

      
Application Number 17987255
Status Pending
Filing Date 2022-11-15
First Publication Date 2023-03-09
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley C
  • Messer, Ellen
  • Wolfe, Katherine

Abstract

A biosensor assembly that measures multiple physical parameters is disclosed. The biosensor assembly includes a first implantable probe and a first skin contacting electrode. Wherein a first physiological parameter is measured between the first implantable probe and the first skin contactable electrode.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/25 - Bioelectric electrodes therefor

20.

ANALYTE SENSOR

      
Application Number 17638405
Status Pending
Filing Date 2020-08-31
First Publication Date 2022-09-29
Owner PERCUSENSE, INC. (USA)
Inventor
  • Liang, Bradley
  • Shah, Rajiv

Abstract

In one embodiment, a working electrode measuring the presence of a first analyte is disclosed. The working electrode includes a working conductor that has a first electrode reactive surface. The working electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry. Additionally, a first reactive chemistry that is responsive to the first analyte is included in the working electrode. The first reactive chemistry includes a mediator, an enzyme and a cofactor. Wherein the first reactive chemistry is located between the working conductor and the first transport material.

IPC Classes  ?

  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • G01N 27/327 - Biochemical electrodes
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
  • C12Q 1/32 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase involving dehydrogenase

21.

In vivo sensing and infusion devices

      
Application Number 17406244
Grant Number 11806135
Status In Force
Filing Date 2021-08-19
First Publication Date 2022-08-11
Grant Date 2023-11-07
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Messer, Ellen
  • Wolfe, Katherine
  • Pendo, Shaun

Abstract

Sensing and infusion devices are described. In one embodiment, a sensing and infusion device may include an implantable segment having a sensor. The sensing and infusion device may also include a catheter, and a sensor channel may be formed in the catheter. The sensor channel may be configured to retain at least a portion of the implantable segment.

IPC Classes  ?

  • A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
  • A61M 5/142 - Pressure infusion, e.g. using pumps

22.

ANALYTE SENSOR

      
Application Number 17683034
Status Pending
Filing Date 2022-02-28
First Publication Date 2022-06-16
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley C.
  • Wolfe, Katherine
  • Messer, Ellen K.
  • Pendo, Shaun M.

Abstract

A working electrode measuring the presence of an analyte is described as one embodiment. The working electrode includes a working conductor with a reactive surface that is operated at a first potential. The working electrode further includes a first transport material with properties that enable analyte flux to the reactive surface. Additionally, the working electrode has a second transport material with properties that enable reactant flux to the reactive surface, wherein the analyte flux and the reactant flux are in dissimilar directions.

IPC Classes  ?

  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/1495 - Calibrating or testing in vivo probes
  • G01N 27/327 - Biochemical electrodes

23.

SENSOR AND CANNULA

      
Application Number 17187571
Status Pending
Filing Date 2021-02-26
First Publication Date 2021-09-02
Owner PercuSense, Inc. (USA)
Inventor Wolfe, Katherine

Abstract

In one embodiment, an integrated cannula and sensor assembly is disclosed. The integrated cannula and sensor assembly includes a cannula with a proximal end and a distal end. The cannula also has a body and a tip. The body includes a channel and a body distal that is defined between the proximal end and the distal end. The tip is defined between the body distal and the distal end. The assembly further includes a sensor assembly that is located within the channel, wherein the tip further includes an undercut configured to retain the sensor assembly.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter

24.

System and method for disease risk assessment and treatment

      
Application Number 17100833
Status Pending
Filing Date 2020-11-21
First Publication Date 2021-08-05
Owner Percusense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley C
  • Sutorius, Bahar
  • Wolfe, Katherine
  • Messer, Ellen
  • Pendo, Shaun

Abstract

An apparatus for early detection of sepsis in a host is disclosed. The apparatus includes a first sensor to directly measure a glucose level, a second sensor to directly measure a lactate level and a third sensor to directly measure a tissue oxygen level. The first sensor, the second sensor, and the third sensor all being inserted at a single point of entry in a subcutaneous space of the host such that a predetermined correlation between the glucose level, lactate level, and tissue oxygen level signals conditions related to sepsis.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
  • A61B 5/07 - Endoradiosondes
  • A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
  • A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
  • A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter

25.

ANALYTE SENSOR

      
Application Number US2020048743
Publication Number 2021/042033
Status In Force
Filing Date 2020-08-31
Publication Date 2021-03-04
Owner PERCUSENSE, INC. (USA)
Inventor
  • Liang, Bradley
  • Shah, Rajiv

Abstract

In one embodiment, a working electrode measuring the presence of a first analyte is disclosed. The working electrode includes a working conductor that has a first electrode reactive surface. The working electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry. Additionally, a first reactive chemistry that is responsive to the first analyte is included in the working electrode. The first reactive chemistry includes a mediator, an enzyme and a cofactor. Wherein the first reactive chemistry is located between the working conductor and the first transport material.

IPC Classes  ?

  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
  • G01N 27/327 - Biochemical electrodes

26.

Combined infusion set and sensor

      
Application Number 16936754
Grant Number 11547812
Status In Force
Filing Date 2020-07-23
First Publication Date 2021-01-28
Grant Date 2023-01-10
Owner PercuSense, Inc. (USA)
Inventor
  • Wolfe, Katherine
  • Shah, Rajiv

Abstract

In one embodiment, an infusion set and sensor assembly delivered within a subject is disclosed. The assembly includes a cannula that is terminated at a cannula opening. The assembly further includes a sharp that is at least partially within the hollow of the cannula. A sensor having a proximal end and a distal end is also included in the assembly. The proximal end of the sensor is held in a fixed location while the distal end is retained with a portion of the cannula. The sensor further includes sensor slack, wherein transitioning the sharp from a first position to a second position simultaneously inserts the cannula and sensor to a desired insertion depth within a subject via a single point of insertion.

IPC Classes  ?

  • A61M 5/46 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for controlling depth of insertion
  • A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
  • A61M 5/142 - Pressure infusion, e.g. using pumps

27.

ANALYTE SENSOR

      
Application Number 16894822
Status Pending
Filing Date 2020-06-07
First Publication Date 2020-12-10
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Wolfe, Katherine
  • Pendo, Shaun

Abstract

A sensor assembly is disclosed. The sensor assembly having a first conductor and a second conductor being separated by an insulator. The sensor assembly further has an aperture that is formed through the first conductor, the second conductor and the insulator, wherein formation of the aperture creates an electrical short circuit between the first conductor and the second conductor.

IPC Classes  ?

  • A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value

28.

Analyte sensor

      
Application Number 16625884
Grant Number 11553862
Status In Force
Filing Date 2018-06-22
First Publication Date 2020-05-14
Grant Date 2023-01-17
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley
  • Wolfe, Katherine
  • Messer, Ellen
  • Pendo, Shaun

Abstract

An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

IPC Classes  ?

  • A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

29.

ANALYTE SENSOR

      
Application Number 16152727
Status Pending
Filing Date 2018-10-05
First Publication Date 2019-08-29
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley C.
  • Bowman, Ellen
  • Wolfe, Katherine
  • Pendo, Shuan

Abstract

An electrode measuring the presence of an analyte is disclosed. The electrode includes a working conductor with an electrode reactive surface. The working electrode further includes a first reactive chemistry that is responsive to a first analyte. Additionally, the working electrode includes a first transport material that enables flux of the first analyte to the first reactive chemistry. Further included with the electrodes is a separation chemistry between the first reactive chemistry and the first transport material, the separation chemistry minimizing mixing of the first reactive chemistry and the first transport material.

IPC Classes  ?

  • G01N 27/327 - Biochemical electrodes
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

30.

Multi-analyte continuous glucose monitoring

      
Application Number 16273920
Grant Number 11284816
Status In Force
Filing Date 2019-02-12
First Publication Date 2019-08-15
Grant Date 2022-03-29
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley C
  • Bowman, Ellen
  • Wolfe, Katherine

Abstract

A system to automatically detect at least one physiological state is disclosed. The system includes a single probe for insertion within a subject that has an analyte sensor array for continuous monitoring of at least glucose and a second analyte. The system further includes an electronics module that includes a power supply, a processor, memory and a bi-directional communications module. When the electronics module is coupled with the analyte sensor array the power supply delivers power to the analyte sensor array and the processor. The processor analyzing glucose and the second analyte data to detect a first physiological state from a plurality of physiological states.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
  • A61B 5/1495 - Calibrating or testing in vivo probes
  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase

31.

System and method for disease risk assessment and treatment

      
Application Number 16054649
Grant Number 11529053
Status In Force
Filing Date 2018-08-03
First Publication Date 2019-06-20
Grant Date 2022-12-20
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley C
  • Messer, Ellen
  • Wolfe, Katherine

Abstract

A biosensor assembly that measures multiple physical parameters is disclosed. The biosensor assembly includes a first implantable probe and a first skin contacting electrode. Wherein a first physiological parameter is measured between the first implantable probe and the first skin contactable electrode.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0408 - Electrodes specially adapted therefor
  • A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/25 - Bioelectric electrodes therefor
  • A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • A61B 5/283 - Invasive
  • A61B 5/349 - Detecting specific parameters of the electrocardiograph cycle

32.

Sensor insertion

      
Application Number 15816549
Grant Number 10849539
Status In Force
Filing Date 2017-11-17
First Publication Date 2018-10-04
Grant Date 2020-12-01
Owner PercuSense, Inc. (USA)
Inventor
  • Wolfe, Katherine
  • Ferreira, Joseph
  • Messer, Ellen
  • Shah, Rajiv
  • Chan, Konrad

Abstract

An on-body insertion system is described. The on-body system includes a sensor in a first position being substantially parallel to an insertion surface. Activation of an actuator transitions the sensor to a second position. Wherein the transition imparts movement to the sensor that is substantially parallel to the insertion surface and the second position results in the sensing area being beneath the insertion surface.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 17/34 - TrocarsPuncturing needles

33.

Analyte sensor

      
Application Number 15472194
Grant Number 11298059
Status In Force
Filing Date 2017-03-28
First Publication Date 2017-11-16
Grant Date 2022-04-12
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley
  • Wolfe, Katherine
  • Messer, Ellen K
  • Pendo, Shaun M

Abstract

A working electrode measuring the presence of an analyte is described as one embodiment. The working electrode includes a working conductor with a reactive surface that is operated at a first potential. The working electrode further includes a first transport material with properties that enable analyte flux to the reactive surface. Additionally, the working electrode has a second transport material with properties that enable reactant flux to the reactive surface, wherein the analyte flux and the reactant flux are in dissimilar directions.

IPC Classes  ?

  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 5/1495 - Calibrating or testing in vivo probes
  • G01N 27/327 - Biochemical electrodes

34.

System and method for disease risk assessment and treatment

      
Application Number 15417055
Grant Number 10888281
Status In Force
Filing Date 2017-01-26
First Publication Date 2017-11-16
Grant Date 2021-01-12
Owner PercuSense, Inc. (USA)
Inventor
  • Shah, Rajiv
  • Liang, Bradley
  • Sutorius, Bahar
  • Wolfe, Katherine
  • Messer, Ellen
  • Pendo, Shaun

Abstract

An apparatus for early detection of sepsis in a host is disclosed. The apparatus includes a first sensor to directly measure a glucose level, a second sensor to directly measure a lactate level and a third sensor to directly measure a tissue oxygen level. The first sensor, the second sensor, and the third sensor all being inserted at a single point of entry in a subcutaneous space of the host such that a predetermined correlation between the glucose level, lactate level, and tissue oxygen level signals conditions related to sepsis.

IPC Classes  ?

  • A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
  • A61B 5/07 - Endoradiosondes
  • A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
  • A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
  • A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
  • A61B 5/01 - Measuring temperature of body parts
  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase