Abstract

The present invention provides a new and improved surgical mesh for hernia repair which provides antimicrobial activity and fibroblast proliferating activity. The surgical mesh is comprised of a polymeric substate coated with benzalkonium chloride.

IPC Classes  ?

• A61L 31/04 - Macromolecular materials
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances

Abstract

The present invention relates to a synthesis method of a series of new biodegradable, hydrophilic materials in the form of a film and prepared from a semi-impenetrable network (semi-IPN) of poly(3-hydroxybutyrate-co-3-valerate) and cross-linked alginate, with physicochemical and biological properties suitable for industrial and biomedical applications.

IPC Classes  ?

• C08L 5/04 - Alginic acidDerivatives thereof
• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• C08K 3/04 - Carbon
• A61F 13/00 - Bandages or dressingsAbsorbent pads
• A61L 15/28 - Polysaccharides or their derivatives
• A61K 31/765 - Polymers containing oxygen
• A61P 31/12 - Antivirals
• A01N 65/03 - Algae
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof

Abstract

The present invention describes a facial protection element for protection against risks of exposure to infectious biological agents, such as microorganisms, like a virus with an envelope, including SARS-CoV-2 and the multidrug-resistant Gram-positive bacteria. Specifically, the present invention relates to a facial protection element of the type comprising: face shields, glasses, masks, counter shields, etc., which prevent not only direct exposure to the infectious biological agent, but rather also inactivate same once the biological agent comes into contact with the facial protection element. The facial protection element comprises a plastic material or glass with a biocidal agent coating layer.

IPC Classes  ?

• A62B 23/02 - Filters for breathing-protection purposes for respirators
• A41D 13/11 - Protective face masks, e.g. for surgical use, or for use in foul atmospheres

Abstract

Provided herein are methods and compositions related to treating motor neuron diseases, such as ALS, in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.

IPC Classes  ?

• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61K 31/09 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
• A61K 31/23 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

CoronaviridaeCoronaviridae, Orthomyxoviridae, Filoviridae, Flaviviridae, Retroviridae and Togaviridae, such as SARS-CoV-2.

IPC Classes  ?

• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61K 31/14 - Quaternary ammonium compounds, e.g. edrophonium, choline
• A61P 31/14 - Antivirals for RNA viruses
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
• A61K 31/41 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/5375 - 1,4-Oxazines, e.g. morpholine
• C07C 217/18 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted

Abstract

The present invention relates to a hydrophilic biodegradable biomaterial comprising a semi-interpenetrated network (semi-IPN) consisting of a polymer from the polyhydroxyalkanoate (PHA) family and another polyvinyl alcohol (PVA) polymer. Moreover, the invention relates to the method for preparing same and a composition comprising said material, as well as particles with conducting and antimicrobial properties useful for the prevention and treatment of microbial infections and for tissue regeneration by way of the use of cellular substrates based on the biomaterial with and without electrostimulation.

IPC Classes  ?

• C08L 29/04 - Polyvinyl alcoholPartially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• C08L 67/00 - Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chainCompositions of derivatives of such polymers
• C08L 45/00 - Compositions of homopolymers or copolymers of compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic or in a heterocyclic ring systemCompositions of derivatives of such polymers
• A61L 15/26 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bondsDerivatives thereof
• A61F 13/00 - Bandages or dressingsAbsorbent pads

Goods & Services

Teaching and educational services; training services; entertainment and amusement, sports and cultural activities; educational services provided by universities; teaching services and correspondence courses; organization of competitions and awarding of prizes.

Abstract

Provided herein are methods and compositions related to treating motor neuron diseases, such as ALS, in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.

IPC Classes  ?

• A61K 31/05 - Phenols
• A61K 31/09 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
• C07C 15/52 - Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic part substituted by unsaturated hydrocarbon radicals polycyclic non-condensed containing a group with formula
• C07C 39/205 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic part, with unsaturation outside the rings
• C07H 19/02 - Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radicalNucleosidesMononucleotidesAnhydro derivatives thereof sharing nitrogen
• C07H 19/048 - Pyridine radicals

Abstract

The present invention relates to a combination comprising pterostilbeneor pterostilbene phosphate or a pharmaceutically acceptable salt thereof, a glutathione depleting agent and a cancer chemotherapeutic agent. The invention also relates to the medical use of this combination, in particular for the treatment and/or prevention of cancer.

IPC Classes  ?

• A61K 31/09 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
• A61P 35/00 - Antineoplastic agents
• A61K 31/225 - Polycarboxylic acids
• A61K 31/277 - NitrilesIsonitriles having a ring, e.g. verapamil
• A61K 31/42 - Oxazoles
• A61K 31/4412 - Non-condensed pyridinesHydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine

Abstract

The present invention relates to a combination comprising pterostilbeneor pterostilbene phosphate or a pharmaceutically acceptable salt thereof,a glutathione depleting agent and a cancer chemotherapeutic agent. The invention also relates to the medical use of this combination, in particular for the treatment and/or prevention of cancer.

IPC Classes  ?

• A61K 31/09 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
• A61P 35/00 - Antineoplastic agents