Abstract

The present disclosure relates generally to methods for producing stucco compositions useful in making gypsum products. One aspect of the disclosure is a method for producing a stucco composition using dielectric calcination. Another aspect of the disclosure is a production process for a gypsum product using a stucco composition prepared by dielectric calcination.

IPC Classes  ?

• B28B 1/14 - Producing shaped articles from the material by simple casting, the material being neither forcibly fed nor positively compacted
• B28C 5/00 - Apparatus or methods for producing mixtures of cement with other substances, e.g. slurries, mortars, porous or fibrous compositions
• B28C 7/12 - Supplying or proportioning liquid ingredients
• C04B 11/036 - Devices therefor for the dry process, e.g. dehydrating in a fluidised bed or in a rotary kiln

IPC Classes  ?

• A22B 7/00 - Slaughterhouse arrangements
• A22C 21/00 - Processing poultry
• B65G 47/04 - Devices for feeding articles or materials to conveyors for feeding articles

IPC Classes  ?

• G21C 7/32 - Control of nuclear reaction by varying flow of coolant through the core
• G21C 9/016 - Core catchers
• G21C 11/08 - Thermal shieldsThermal linings, i.e. for dissipating heat from gamma radiation which would otherwise heat an outer biological shield
• G21C 15/20 - Partitions or thermal insulation between fuel channel and moderator, e.g. in pressure tube reactors
• G21C 15/26 - Promoting flow of the coolant by convection, e.g. using chimneys, using divergent channels

IPC Classes  ?

• A61L 2/28 - Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12Q 1/22 - Testing for sterility conditions

IPC Classes  ?

• A61L 2/28 - Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
• C12Q 1/22 - Testing for sterility conditions
• G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath

IPC Classes  ?

• A61M 5/158 - Needles
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

IPC Classes  ?

• B60W 40/072 - Curvature of the road
• G01S 19/03 - Cooperating elementsInteraction or communication between different cooperating elements or between cooperating elements and receivers
• G08G 1/01 - Detecting movement of traffic to be counted or controlled

IPC Classes  ?

• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 2013/02 -
• A61L 15/60 - Liquid-swellable gel-forming materials, e.g. super-absorbents
• A61L 27/52 - Hydrogels or hydrocolloids
• C08J 3/075 - Macromolecular gels
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08L 101/14 - Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity the macromolecular compounds being water soluble or water swellable, e.g. aqueous gels
• C12N 1/26 - Processes using, or culture media containing, hydrocarbons

IPC Classes  ?

• A61L 31/14 - Materials characterised by their function or physical properties
• C08J 3/075 - Macromolecular gels
• C08J 3/28 - Treatment by wave energy or particle radiation

IPC Classes  ?

• C12M 1/26 - Inoculator or sampler
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

System and method for collection and separation of human waste are described. The system can include a vessel (102) configured to receive human waste and a solids separator (106). The solids separator can include a vacuum tank as well as an inlet chamber formed within the vacuum tank at the top portion, a solids containment portion formed in the base of the vacuum tank and positioned centrally within the vacuum tank, a liquid containment portion formed in the base of the vacuum tank and contained within the vacuum tank surrounding the solids containment portion, and a separating filter having a cylindrical tubular shape and extending from the inlet chamber outlet to the solids containment portion. The separating filter forming a central separation volume within the vacuum tank. The inlet chamber is configured to receive the combined waste via an inlet (132) and to direct the combined waste to the central separation volume. The liquid portion of the combined waste allowed to flow through the separating filter to an outer portion surrounding the central separation volume and to collect in the liquid containment portion of the base. The solids portion of the combined waste contained within the central separation volume and collected in the solids containment portion of the base.

IPC Classes  ?

• B01D 29/35 - Self-supporting filtering elements arranged for outward flow filtration
• B01D 29/90 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor having feed or discharge devices for feeding
• C02F 11/121 - Treatment of sludgeDevices therefor by de-watering, drying or thickening by mechanical de-watering
• C02F 11/128 - Treatment of sludgeDevices therefor by de-watering, drying or thickening by mechanical de-watering using batch processes
• E03D 5/014 - Special constructions of flushing devices combined with movable closure elements in the bowl outlet with devices for separate removal of liquids and solids
• E03D 11/11 - Bowls combined with a reservoir, e.g. containing apparatus for disinfecting or for disintegrating

Abstract

An automated immersive chilling system wherein the system may comprise a shackle and a track. The shackle may be configured to cooperatively attach to a product to be cooled. The track may be configured to move the shackle along a processing line wherein the processing line may comprise one or more curved channels retaining a reservoir of a cooling medium. The shackle may be configured to move the product within the reservoir to agitate the cooling medium. The shackle can be a rotating shackle that can be configured to move the product within the reservoir to agitate the cooling medium by rotating the shackle in the reservoir of the cooling medium. The shackle may be further configured to move the product within the reservoir to agitate the cooling medium by vibrating the shackle in the reservoir.

IPC Classes  ?

• A22B 7/00 - Slaughterhouse arrangements
• A22C 21/00 - Processing poultry

Abstract

An exemplary embodiment of the present disclosure provides a device for monitoring salivary electrolytes. The device can include a control circuit, a sensor coupled to the control circuit, and a biocompatible body configured to be inserted into a mouth of a user. The biocompatible body can be configured to house the control circuit and the sensor, and the sensor can be configured to receive saliva from the user and measure an electrolyte level present in the saliva.

IPC Classes  ?

• G01N 33/487 - Physical analysis of biological material of liquid biological material
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

An exemplary embodiment of the present disclosure provides a cathode for use in an alkali metal-ion battery, the cathode comprising a metal halide crystal lattice. The metal halide has a formula: (Fe1-zMa)(ClyX3-y), where Mi is a metal, X is a halogen, a is between 0 and 2.9, z is between 1 and 0, and y is between 0 and 3. Metal M can be a metal selected from the group consisting of titanium, chromium, manganese, cobalt, nickel, copper, zinc, molybdenum, technetium, ruthenium, vanadium, tungsten, rhenium, osmium, lithium, sodium, potassium, rubidium, or cesium, and halogen X can be selected from fluorine, bromine, or iodine.

IPC Classes  ?

• G01N 23/20 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using diffraction of the radiation by the materials, e.g. for investigating crystal structureInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materialsInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using reflection of the radiation by the materials
• H01M 4/40 - Alloys based on alkali metals
• H01M 4/42 - Alloys based on zinc
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates

Abstract

Disclosed herein are porous silica materials comprising a plurality of micropores, each having a pore size from approximately 0.1 nm to approximately 2 nm; a plurality of mesopores, each of the plurality of mesopores having a pore size from approximately 2 nm to approximately 50 nm; and a plurality of macropores, each of the plurality of macropores having a pore size from approximately 50 nm to approximately 50,000 nm. The porous silica materials can comprise a hygroscopic salt material dispersed within the plurality of mesopores such that the hygroscopic salt material resides in the plurality of mesopores. The hygroscopic salt material can be present in the porous silica material in an amount from approximately 10% to approximately 50% by weight, based on the total weight of the porous silica material.

IPC Classes  ?

• B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties

Abstract

A microneedle patch for creating a tattoo image on skin, wherein the microneedle patch includes a backing layer, and an array of microneedles extending from the backing layer, wherein the microneedles each include a distal tip portion that has a tattoo substance, wherein the microneedles are configured to be inserted into a subject's skin and to release the tattoo substance in the skin, thereby creating a tattoo image in the skin that is visible to the human eye. Each microneedle in the array of microneedles may correspond to a dot, or a pixel, of the tattoo image or a portion thereof.

IPC Classes  ?

• A01K 11/00 - Marking of animals
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

IPC Classes  ?

• G05F 1/66 - Regulating electric power
• H02J 3/18 - Arrangements for adjusting, eliminating or compensating reactive power in networks
• H02J 3/50 - Controlling the sharing of the out-of-phase component

Abstract

An exemplary embodiment of the present disclosure provides a battery system comprising one or more battery modules, one or more thermal conduits, and one or more thermoelectric coolers. Each of the one or more battery modules can comprise a plurality of battery cells. The one or more thermal conduits can be coupled to the one or more battery modules. The one or more thermoelectric coolers can be coupled to the one or more thermal conduits. The one or more thermal conduits can be configmed to allow thermal energy to flow from the one or more battery modules to the one or more thermoelectric coolers. The thermoelectric coolers can be configmed to dissipate thermal energy received from the one or more battery modules via the one or more thermal conduits.

IPC Classes  ?

• F25B 21/02 - Machines, plants or systems, using electric or magnetic effects using Peltier effectMachines, plants or systems, using electric or magnetic effects using Nernst-Ettinghausen effect
• H01M 4/06 - Electrodes for primary cells
• H01M 10/63 - Control systems
• H01M 10/6572 - Peltier elements or thermoelectric devices

Abstract

Microneedles for drug delivery that include a wax or other meltable material and methods of making and using such microneedles are disclosed. A microneedle patch includes a backing layer; and an array of microneedles extending from the backing layer, wherein the microneedles each include a distal tip portion that includes a drug, and the microneedles are configured to be inserted into mammalian tissue and, at least a portion of each of the microneedles is configured to melt in the mammalian tissue. In some other cases, melt materials are used during manufacturing of the microneedles but do not melt in the skin.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A system (300) for moving a load (10) on a floor to a selected destination includes plurality of robots (320). Each robot (100) includes at least two wheels (112) and a motor (136). Each robot (100) fits underneath the load (10). A lifting device secured to each robot (100) has a retracted state and a lifting state so that the robot (100) and the lifting device (120) can fit into the open area (14) when the lifting device (120) is in the retracted state and so that the load (10) is lifted off of the floor (11) when the lifting device (120) is in the lifting state. A central server (310) determines a configuration of robots to lift the load (10), assigns robots and instructs the robots to go under the load (10), lift the load (10) and move the load (10) to the destination (30).

IPC Classes  ?

• B25J 19/02 - Sensing devices
• B66F 9/06 - Devices for lifting or lowering bulky or heavy goods for loading or unloading purposes movable, with their loads, on wheels or the like, e.g. fork-lift trucks
• B66F 9/075 - Constructional features or details

Abstract

An exemplary embodiment of the present disclosure provides a current source converter, comprising a transformer, a first circuit, and a second circuit. The transformer can comprise a first winding, a second winding, and a third winding. The first circuit can be electrically coupled to the first and second windings. The first circuit can comprise a battery port and a photovoltaic (PV) port. The battery port can be configured to interface with one or more batteries. The PV port can be configured to interface with one or more PV modules. The second circuit can be electrically coupled to the third winding. The second circuit can comprise an alternating current (AC) port configured to interface with an AC load.

IPC Classes  ?

• H02S 40/30 - Electrical components

Abstract

Methods are provided for appending amines to metal organic framework (MOF) compositions. In some aspects, the methods can allow for appending of amines in the solution or synthesis solution used for synthesizing a MOF. In such aspects, an amine-appended MOF can be formed without having to first separate and dry the underlying non-amine-appended MOF composition. In other aspects, amines can be appended to an existing MOF composition by exposing the MOF to a suitable amine in a protic solvent, such as water or an alcohol.

IPC Classes  ?

• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material

Abstract

Methods are provided for administering a therapeutic agent to an eye of a patient, wherein the method includes (i) inserting a microneedle into the eye of the patient, wherein the microneedle extends through the sclera and choroid layers, but not into the vitreous, and without a vitrectomy or a retinotomy; and (ii) injecting a fluid comprising a therapeutic agent through a lumen of the microneedle and into a subretinal space of the eye, wherein the microneedle has (i) a beveled tip with a bevel angle from 40º to 70º and (ii) an outer diameter that is less than 150 µm.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery
• A61M 5/158 - Needles

Abstract

An exemplary embodiment of the present disclosure provides a current sensor comprising a current input, a current output, a first current path, and a second current path parallel to the first current path, a Rogowski coil current sensor, and a controller. The first current path can comprise a first switch. When the first switch is in a closed position, current can flow along the first current path between the current input and the current output. The second current path can comprise a second switch. When the second switch is in a closed position, current can flow along the second current path between the current input and the current output. At least one of the first current path and the second current path can pass through an aperture of the Rogowski coil. The controller can be configured to control the first and second switches.

IPC Classes  ?

• G01R 15/18 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers
• G01R 19/15 - Indicating the presence of current
• G01R 31/58 - Testing of lines, cables or conductors
• H01F 38/30 - Constructions

Abstract

An exemplary embodiment of the present disclosure provides a grid edge node, comprising a power supply, one or more sensors, a telecommunications radio, and a backhaul connection. The power supply can be configured to receive input power from a power transformer mounted to a utility pole. The one or more sensors can be configured to monitor one or more conditions of the power transformer. The telecommunications radio can be configured to transmit and receive wireless telecommunications signals to and from remote devices in a telecommunications network. The backhaul connection can be configured to provide communication between the grid edge node and a cloud-based monitoring system. The grid edge node can be configured to transmit data indicative of the one or more monitored conditions to the cloud-based monitoring system via the backhaul connection. The grid edge node can be further configured to be mounted to the utility pole.

IPC Classes  ?

• G05F 1/66 - Regulating electric power
• H02J 13/00 - Circuit arrangements for providing remote indication of network conditions, e.g. an instantaneous record of the open or closed condition of each circuitbreaker in the networkCircuit arrangements for providing remote control of switching means in a power distribution network, e.g. switching in and out of current consumers by using a pulse code signal carried by the network

Abstract

The digital suture devices can accurately record electrical activity in muscles, while reducing both tissue damage and increasing ease of use. In some examples, the digital suture device can include an adapter configured to be connected to a data collection and/or stimulus control system. The device can further include a sensor body electrically and mechanically connected to the adapter. The sensor body may include one or more sensor members extending from the adapter. Each sensor member may include a first section distal to the adapter, a second section including one or more arrays of one or more stimulating/sensing sites, and a third section configured to be used with a delivery device. The second section may be disposed between the first section and the third section. Each sensor member may include one or more sets of tissue engaging members disposed along a length of the second section.

IPC Classes  ?

• A61B 5/296 - Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]
• A61B 5/389 - Electromyography [EMG]

Abstract

An exemplary embodiment of the present disclosure provides an extended reality (XR) system comprising an autonomous robotic device and a user interface. The autonomous robotic device can be located in a physical environment. The user interface can be configured to display an XR environment corresponding to at least a portion of the physical environment and receive an input from the user based on the user's perception in the XR environment. The autonomous robotic device can be configured to perform an autonomous action based at least in part on an input received from the user.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06N 3/02 - Neural networks
• G06N 20/00 - Machine learning
• G06T 19/00 - Manipulating 3D models or images for computer graphics

Abstract

System and method for micro-Super Critical Water Oxidation solids treatment of fecal waste are described. The system includes an injector vessel (112) and a reactor (114). The reactor can receive an injection of a slurry batch and an input of compressed air that is heated over time to a temperature at or above the critical point of water into the super critical fluid phase. A combined concentrator and phase separator (150) can receive a treated output from the reactor and separate solid ash from liquid and gaseous effluent. A drying tunnel (170) can receive and dry the solid ash. The treatment process includes heating the slurry batch, within the reactor, to a temperature of at or above the critical point of water into the super critical fluid phase and maintaining the slurry batch a minimum temperature, within the reactor, for a predetermined treatment time to produce a treated output.

IPC Classes  ?

• C02F 11/08 - Wet air oxidation
• C02F 11/13 - Treatment of sludgeDevices therefor by de-watering, drying or thickening by heating

Abstract

System and method for a urine and wastewater treatment are described. The urine and wastewater treatment system can include a tank configured to receive liquid waste (102), an air blower (114) configured to blow air into the liquid waste to reduce the density of the liquid waste and to generate crossflow, and a filtration unit comprising an ultra-filtration stage (104) comprising a first permeate outlet and a first concentrate outlet and a reverse osmosis stage (112) comprising a second permeate outlet and a second concentrate outlet. The reverse osmosis stage is configured to receive a first permeate from the ultra-filtration stage.

IPC Classes  ?

• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 61/14 - UltrafiltrationMicrofiltration
• B01D 61/16 - Feed pretreatment
• B01D 61/58 - Multistep processes
• C02F 1/20 - Treatment of water, waste water, or sewage by degassing, i.e. liberation of dissolved gases
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
• C02F 1/74 - Treatment of water, waste water, or sewage by oxidation with air
• C02F 3/20 - Activated sludge processes using diffusers
• C02F 11/121 - Treatment of sludgeDevices therefor by de-watering, drying or thickening by mechanical de-watering

Abstract

System and method for buffer tank separation and homogenization are described. The system can include a belt separator (104), a liquids collection tank (106), a solids collection tank (108), and a homogenizer (110). The belt separator comprising a perforated belt looped between two rollers, the belt separator positioned to receive an input comprising at least one of: solids and liquids, the input received via the at least one inlet onto the belt of the belt separator, the belt separator configured to deliver a solids portion of the input to the solids collection tanks and to deliver the liquids portion of the input to the liquids collection tank; and a homogenizer connected to the solids outlet, the homogenizer configured to receive a collected solids portion output and form a uniform and homogenized slurry.

IPC Classes  ?

• A47K 11/02 - Dry closets, e.g. incinerator closets
• C02F 11/123 - Treatment of sludgeDevices therefor by de-watering, drying or thickening by mechanical de-watering using belt or band filters

Abstract

System and method for volume reduction solids treatment for fecal waste are described. The system can include a pasteurizer (102) configured to receive a slurry batch and heat the slurry batch at an elevated temperature for a time period to produce a pathogen free slurry. The system can also include a mechanical dewatering press (104) configured to compress the pathogen free slurry to separate a liquid phase from a volume reduced solid waste. The volume reduced solid waste being formed into a feces cake. The system can also include a means to remove the liquid phase and a drying tunnel (106) comprising a conveyor housed and an air duct system. The air duct system configured to propel forced air over the feces cake.

IPC Classes  ?

• C02F 11/122 - Treatment of sludgeDevices therefor by de-watering, drying or thickening by mechanical de-watering using filter presses
• C02F 11/13 - Treatment of sludgeDevices therefor by de-watering, drying or thickening by heating

Abstract

Disclosed are compositions comprising chitin nanofibers (ChNF) and silver chitosan (AgCh) and/or silver-copper chitosan (AgCuCh). Also disclosed are methods of coating various substrates with the disclosed compositions in order to impart antiviral and antimicrobial properties, as well as oxygen and water vapor barrier properties, to the substrate. Coated substrates made by the disclosed methods are also disclosed.

IPC Classes  ?

• A61L 2/18 - Liquid substances
• A61L 27/04 - Metals or alloys
• A61L 27/22 - Polypeptides or derivatives thereof
• C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides
• C09D 7/61 - Additives non-macromolecular inorganic
• C09D 105/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof

Abstract

The present disclosure provides hydrogels, more particularly hydrolytically degradable hydrogels containing cleavable ester moieties and their use in such applications as tissue engineering and therapeutic delivery.

IPC Classes  ?

• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/52 - Hydrogels or hydrocolloids
• C08J 3/075 - Macromolecular gels
• C08K 5/11 - EstersEther-esters of acyclic polycarboxylic acids

Abstract

Ink compositions are provided for using solvent-based additive manufacturing (SBAM) techniques to form contactor structures and/or structures for use in an adsorption or absorption contactor. Methods forming a contactor using SBAM are also provided. The ink compositions can include a substantial content of adsorbent particles to provide enhanced adsorption by a contactor. Metal organic framework (MOF) structures and zeotype framework structures are examples of types of adsorbent particles that can be incorporated into an ink composition for forming a contactor structure by SBAM. The ink can further include a polymeric component that can serve as the structural component of a polymeric structural material produced by the additive manufacturing method. Such a structural material can correspond to a polymeric material with incorporated adsorbent particles. In some aspects, the polymeric structural material and/or the adsorbent particles can have selectivity for adsorption of CO2 from a process fluid flow.

IPC Classes  ?

• B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
• B29C 64/209 - HeadsNozzles
• B29C 64/371 - Conditioning of environment using an environment other than air, e.g. inert gas

Abstract

Fiber compositions are provided that incorporate metal organic framework (MOF) materials into the polymeric matrix of the fiber. The metal organic framework materials can be incorporated by including MOF particles into a "dope" or synthesis solution used to form the fiber. The dope solution can then be used to form fibers that include 5.0 wt% or more of MOF in the resulting polymeric structural material of the fiber, relative to a weight of the fibers. In some aspects, the metal organic framework material can correspond to a MOF with selectivity for adsorption of CO2.

IPC Classes  ?

• B01D 69/14 - Dynamic membranes
• B01D 71/02 - Inorganic material
• B01D 71/68 - PolysulfonesPolyethersulfones

Abstract

Contactor structures are provided that can allow for improved heat management while reducing or minimizing the potential for contamination of process gas streams with heat transfer fluids. The contactor structures can include one or more sets of flow channels for process gas flows, such as gas flows introduced to allow adsorption of components from a gas stream or gas flows introduced to facilitate desorption of previously adsorbed components into a purge gas stream. The process gas flow channels can correspond to flow channels defined by a structural material of unitary structure. The unitary structure can correspond to the entire contactor, or the unitary structure can correspond to a monolith that forms a portion of the contactor. The contactor structures can also include one or more sets of flow channels for heat transfer fluids. The heat transfer flow channels can also be defined by the structural material of a unitary structure.

IPC Classes  ?

• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
• C10L 3/10 - Working-up natural gas or synthetic natural gas

Abstract

A heart valve model includes a parametric leaflet model representing geometries of a heart valve constructed based on at least one landmark point associated with the heart valve. The heart valve model includes a ray casted anatomical structure constructed based on an automatic aortic root reconstruction algorithm to extract a shape of an aorta. The heart valve also includes an additional anatomical structure, wherein the parametric leaflet model, the ray casted anatomical structure, and the additional anatomical structure are combined to obtain the heart valve model.

IPC Classes  ?

• A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61F 2/24 - Heart valves
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• G06Q 40/04 - Trading Exchange, e.g. stocks, commodities, derivatives or currency exchange

Abstract

A model of an in vivo heart valve device implanted in a patient is generated by providing a known model of a pre-implantation heart valve device, performing an imaging scan on the patient having an implanted heart valve device to obtain at least one patient specific landmark, deforming the known model to fit the at least one patient specific landmark to obtain a constructed patient-specific valve model, and simulating a valve leaflet and skirt for the constructed patient-specific valve model by finite element analysis. The constructed patient-specific valve model accurately represents geometries of the implanted heart valve device in its current in vivo form with an error less than 0.5 mm.

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]
• G06T 17/05 - Geographic models

Abstract

A predictive model for classification of tissue rupture risk is generated by providing a computer aided design (CAD) model suitable for simulating a balloon expandable transcatheter heart valve, and computing stress, strain, and/or displacement at the tissue as a function of expansion of the expandable transcatheter heart valve. The computed stress, strain, and/or displacement at the tissue enables determination of low, moderate or high tissue rupture risk as a function of the expansion at time of the expandable transcatheter heart valve deployment into a patient.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61F 2/24 - Heart valves
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Abstract

A high-throughput, scalable, low-cost, on-chip microfluidic potency assay for nondifferentiated cells such as human mesenchymal stromal cells (hMSCs) with improved functional predictive power and recapitulation of in vivo secretory responses compared to traditional approaches. By comparison of hMSC secretory responses to functional hMSC- medicated immune cell suppression, on-chip microfluidic potency markers are identified with improved functional predictive power compared to traditional planar methods.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Abstract

An exemplary embodiment provides a power conversion system comprising a first battery module, a second battery module, first and second transformers, and first, second, and third current source converter bridges. The transformers can have low voltage sides and high voltage sides. The first bridge can be configured to connect the battery modules and the low voltage sides of the transformers. A mid-point of the serial connection of the battery modules can be connected to a mid-point of the series connection of the transformers. The second bridge can connect to the high voltage side of the first transformer and one or more ports configured to transmit electrical power to and/or receive electrical power from an electrical load and/or source. The third bridge can be configured to connect to the high voltage side of the second transformer and the one and one or more ports.

IPC Classes  ?

• H02J 7/14 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from dynamo-electric generators driven at varying speed, e.g. on vehicle
• H02M 7/66 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal
• H02M 7/72 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
• H02M 7/86 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal by dynamic converters
• H02M 7/96 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal by dynamic converters using mechanical contact-making and -breaking parts to interrupt a single potential with moving liquid contacts

Abstract

A universal control (UniCon) scheme for grid-connected converters is presented herein that allows operation automatically in grid-following, grid-firming, and grid-forming modes. The converter does not need information on the grid or connected sources and loads. The converter can set its own operating point based on local measurements. The converter can operate over a wide range of typically encountered steady-state, transient, and fault conditions. UniCon realizes a universal control strategy for converters on the grid, allowing operation in distinct modes, including dispatch in grid connected mode, and automatic load sharing in islanded or microgrid mode. Under transient conditions, the converters provide inertial support and improve damping to stabilize and reduce disturbances. Multiple converters on the system do not require detailed system knowledge or low-latency communications for fast coordination, using communications when available for slow coordination and system level optimization.

IPC Classes  ?

• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type

Abstract

An interferometric chip is provided that includes a substrate having one or more waveguide channels having a sensing layer thereon. Related methods are also provided.

IPC Classes  ?

• G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods

Abstract

A dual-drive power amplifier (PA) where the PA core includes a differential pair of transistors Ml and M2 that are driven by a coupling network having two transmission-line couplers, where a first transmission line section of a coupler is configured to transmit an input signal Vin through to drive a gate of the opposite transistor, while the second transmission line section is grounded at one end and coupled with the first transmission line section such that a coupled portion aVin of the input signal Vin drives the source terminal of a corresponding transistor. The arrangement of the coupling network allows the source terminals to be driven below ground potential. Embodiments disclosed here further provide an input matching network, a driver, an inter-stage matching network, and an output network for practical implementation of the PA core.

IPC Classes  ?

• H03F 1/08 - Modifications of amplifiers to reduce detrimental influences of internal impedances of amplifying elements
• H03F 1/18 - Modifications of amplifiers to reduce detrimental influences of internal impedances of amplifying elements by use of distributed coupling
• H03F 1/22 - Modifications of amplifiers to reduce detrimental influences of internal impedances of amplifying elements by use of cascode coupling, i.e. earthed cathode or emitter stage followed by earthed grid or base stage respectively
• H03F 1/24 - Modifications of amplifiers to reduce detrimental influences of internal impedances of amplifying elements by use of cascode coupling, i.e. earthed cathode or emitter stage followed by earthed grid or base stage respectively in discharge-tube amplifiers
• H03F 1/26 - Modifications of amplifiers to reduce influence of noise generated by amplifying elements
• H03F 1/56 - Modifications of input or output impedances, not otherwise provided for

Abstract

An exemplary motion tracking and/or localization system is disclosed that can provide a non-line-of-sight motion tracking with millimetric accuracy for a tracer moving in close proximity to a magnetic source. In some embodiments, the tracking and/or localization system includes an inertial measurement unit (IMU) configured as a tracer that can move in a local magnetic field generated by multiple local magnetic sources.

IPC Classes  ?

• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
• G01C 17/38 - Testing, calibrating, or compensating of compasses
• G01P 3/44 - Devices characterised by the use of electric or magnetic means for measuring angular speed
• G01P 3/50 - Devices characterised by the use of electric or magnetic means for measuring linear speed
• G01P 21/00 - Testing or calibrating of apparatus or devices covered by the other groups of this subclass

Abstract

Methods and devices are provided for sweat inducement, which is useful in diagnostics, such as diagnosis of cystic fibrosis in a patient. The method includes applying a microneedle patch, which comprises microneedles which comprise pilocarpine or another sweat-inducing agent, to the skin of the patient effective to cause the microneedles to penetrate across the epidermis and into the dermis releasing the pilocarpine or another sweat-inducing agent into the skin in an amount effective to induce secretion of sweat from the skin. The secreted sweat can be collected and analyzed, for example by measuring chloride concentration in the sweat, which may be indicative of cystic fibrosis.

IPC Classes  ?

• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

An exemplary embodiment of the present disclosure provides a system for assessing heart health comprising a first sensor, a second sensor, a processor, and a memory. The first sensor can be configured to measure at least one electrical characteristic of a heart of the user. The second sensor can be configured to measure cardiogenic vibrations of the user. The memory can comprise instructions that, when executed by the processor, cause the processor to generate an assessment of heart health of the user comprising data indicative of filling characteristics of the heart based, at least in part, on measurements from the first sensor and the second sensor.

IPC Classes  ?

• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
• A61B 5/026 - Measuring blood flow
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

An embodiment of the disclosure provides a flexible multiport energy routing system comprising a first port configured to connect to an AC grid, a plurality of second ports configured to connect to a plurality of devices, a step-down transformer, a power converter stack, and a third port. The step-down transformer can a high voltage side electrically coupled to the first port and a low voltage side. The power converter stack can comprise a plurality of power converter modules each having a first converter bridge connected to the low voltage side of the step-down transformer and a second converter bridge connected to one or more of the plurality of second ports. Each of the power converter modules can have a converter transformer connected between the first and second converter bridges. The first and second converter bridges can bidirectionally manage AC and DC power flows between the first, second, and third ports.

IPC Classes  ?

• B60L 53/10 - Methods of charging batteries, specially adapted for electric vehiclesCharging stations or on-board charging equipment thereforExchange of energy storage elements in electric vehicles characterised by the energy transfer between the charging station and the vehicle
• B60L 53/50 - Charging stations characterised by energy-storage or power-generation means
• B60L 53/60 - Monitoring or controlling charging stations
• B60L 53/62 - Monitoring or controlling charging stations in response to charging parameters, e.g. current, voltage or electrical charge

Abstract

An optical waveguide interferometer cartridge system and related methods are provided. The optical waveguide interferometer cartridge system includes a cartridge housing comprising an interferometric chip and a flow cell wafer as well as an alignment means for aligning the cartridge system within the interferometric system.

IPC Classes  ?

• G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods

Abstract

An exemplary embodiment of the present disclosure provides an energy meter comprising a current sensor and an interchangeable voltage sensor. The current sensor can be configured to measure an electrical current flowing through a conductor. The interchangeable voltage sensor detachably can be connected to the current sensor and configured to measure an electrical voltage carried by the conductor.

IPC Classes  ?

• G01R 15/12 - Circuits for multi-testers, e.g. for measuring voltage, current, or impedance at will
• G01R 15/16 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using capacitive devices
• G01R 15/18 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers
• G01R 15/20 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using galvano-magnetic devices, e.g. Hall-effect devices

Abstract

An exemplary embodiment of the present disclosure provides a resonant module and sensing circuits for use with a soft-switching current source converter. The resonant module comprises a resonant switch, a resonant inductor, and a resonant capacitor. The resonant inductor is connected in electrical series with the resonant switch. The resonant capacitor is connected in parallel with the serially connected resonant switch and resonant capacitor. The resonant module further comprises first and second sensing circuits. The first sensing circuit is configured to generate a first sensing signal indicative of when the time derivative of a voltage across the resonant capacitor is negative. The second sensing circuit is configured to generate a second sensing signal indicative of when a voltage across the resonant capacitor is less than or equal to a predetermined threshold value.

IPC Classes  ?

• H02M 7/162 - Conversion of AC power input into DC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only in a bridge configuration
• H02M 7/48 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
• H02M 7/521 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only in a bridge configuration
• H02M 7/523 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only with LC-resonance circuit in the main circuit

Abstract

Embodiments in accordance with the present invention encompass a variety of polymers derived from polycyclic olefin monomers, such as hydrocarbon functionalized norbornenes. The polymers so formed function as ionomers and are suitable as anion exchange membrane for fabricating a variety of electrochemical devices, among others. More specifically, the ionomeric polymers used herein are derived from a variety of quaternized amino functionalized norbornene monomers and are lightly crosslinked (less than ten mol%). The membranes made therefrom exhibit very high ionic conductivity of up to 198 mS/cm at 80 °C. This invention also relates to using an anion conducting solid polymer electrolyte as the ion conducting medium between the two electrodes and the ion conducting medium within the electrodes acting as the ionic conduit between electroactive material and electrolyte. The electrochemical devices made in accordance of this invention are useful as fuel cells, gas separators, and the like.

IPC Classes  ?

• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
• H01M 8/1023 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having only carbon, e.g. polyarylenes, polystyrenes or polybutadiene-styrenes
• H01M 8/1067 - Polymeric electrolyte materials characterised by their physical properties, e.g. porosity, ionic conductivity or thickness

Abstract

Disclosed are PD-L1 presenting compositions. The compositions may be used to effect immunomodulation in a variety of contexts. The compositions may be used to decrease rates of transplant rejection, including pancreatic islet cell transplantation. The compositions are useful for the treatment of type 1 diabetes.

IPC Classes  ?

• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Abstract

Disclosed herein are barium hafnate comprising proton-conducting electrolytes for use in solid oxide fuel cells. The disclosed electrolytes are also useful for electrolysis operations and for carbon dioxide tolerance.

IPC Classes  ?

• H01M 8/00 - Fuel cellsManufacture thereof
• H01M 8/10 - Fuel cells with solid electrolytes
• H01M 8/1016 - Fuel cells with solid electrolytes characterised by the electrolyte material
• H01M 8/1246 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte the electrolyte consisting of oxides
• H01M 8/126 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte the electrolyte consisting of oxides the electrolyte containing cerium oxide

Abstract

An exemplary embodiment of the present disclosure provides a method for charging electric vehicles using service transformers on an electric utility grid. The method can comprise monitoring one or more electrical and/or thermal properties of a plurality of service transformers on an electric utility grid, and based on the monitored one or more electrical and/or thermal properties, determining that one or more of the plurality of service transformers have capacity to charge an electric vehicle.

IPC Classes  ?

• B60L 53/00 - Methods of charging batteries, specially adapted for electric vehiclesCharging stations or on-board charging equipment thereforExchange of energy storage elements in electric vehicles
• B60L 53/10 - Methods of charging batteries, specially adapted for electric vehiclesCharging stations or on-board charging equipment thereforExchange of energy storage elements in electric vehicles characterised by the energy transfer between the charging station and the vehicle
• B60L 53/12 - Inductive energy transfer
• B60L 53/16 - Connectors, e.g. plugs or sockets, specially adapted for charging electric vehicles
• B60L 53/50 - Charging stations characterised by energy-storage or power-generation means

Abstract

A synchronous reverse blocking switch for a soft-switching current source converter (SSCSC), the switch comprising: a first controlled switch; a second controlled switch connected in series to the first controlled switch; and a delay generation circuit configured to control: the second controlled switch to turn on after a delay (t_dON) from the first controlled switch turning on, and the second controlled switch to turn off after a delay (t_dOFF) from the first controlled switch turning off.

IPC Classes  ?

• H02M 1/00 - Details of apparatus for conversion
• H02M 1/08 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters
• H03K 7/00 - Modulating pulses with a continuously-variable modulating signal
• H03K 7/08 - Duration or width modulation

Abstract

Devices and methods are provided for administering a drug to a biological tissue in a patient, such as by intracellular and/or dermal delivery. The device includes a piezoelectric pulse generator; and an array of microneedle electrodes electrically coupled to the piezoelectric pulse generator, wherein the device, following insertion of the microneedle electrodes into the biological tissue, is configured to generate and deliver one or more electrical pulses through the microneedle electrodes effective to electroporate cells in the biological tissue and enable delivery of a drug into the electroporated cells.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61N 1/30 - Apparatus for iontophoresis or cataphoresis
• A61N 1/32 - Applying electric currents by contact electrodes alternating or intermittent currents

Abstract

Methods and compositions are provided for reducing intraocular pressure, for example in the treatment of glaucoma or ocular hypertension. The method includes introducing into a suprachoroidal space of an eye of the patient a composition effective to maintain a reduction in IOP for at least 30 days. The composition may include a cross-linked hydrogel or a material configured to crosslink or further crosslink in vivo.

IPC Classes  ?

• A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
• A61F 9/007 - Methods or devices for eye surgery

Abstract

The current disclosure generally relates to systems and methods of guidewire control, and in particular to systems and methods for the control of multiple degrees-of-freedom bending and the bending length of a coaxially aligned robotically steerable guidewire. The current disclosure is manually actuated, and in others, is automatically/robotically actuated.

IPC Classes  ?

• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61B 34/30 - Surgical robots
• A61B 34/32 - Surgical robots operating autonomously
• A61B 34/35 - Surgical robots for telesurgery
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 25/09 - Guide wires

Abstract

Various implementations include a ground anchoring apparatus including a longitudinal body, first and second retaining members, and a set of expanding linkage assemblies. The first retaining member is rigidly coupled to the longitudinal body. The second retaining member is movably coupled to the longitudinal body. Each expanding linkage assembly includes first and second linkage members. The first linkage member has first and second portions, and the second linkage member has third and fourth portions. The first portion is rotatably coupled to the first retaining member. The fourth portion is rotatably coupled to the second retaining member. The third portion is rotatably coupled to the second portion. The set of expanding linkage assemblies is movable between a collapsed and expanded configuration. The second retaining member is closer to the first retaining member and the third portion is further from the central axis in the expanded configuration than in the collapsed configuration.

IPC Classes  ?

• E02D 5/74 - Means for anchoring structural elements or bulkheads
• E02D 5/80 - Ground anchors

Abstract

Described are substrates including a layer of an aluminum alloy with a conductive coating, also referred to as a protective overlayer. The conductive coating can prevent certain material from coming into contact with the aluminum alloy layer while allowing transmission of electrons to the aluminum alloy. The substrates may be used, for example, in electronics applications, such as current collectors or electrodes for batteries, electrochemical cells, capacitors, supercapacitors, or the like.

IPC Classes  ?

• H01G 11/68 - Current collectors characterised by their material
• H01M 4/66 - Selection of materials
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

Scintillating glass ceramics are disclosed. The scintillating glass ceramics may be used as an x-ray conversion layer (screen) for a flat panel imager (FPD) and as part of an imaging system. The FPD may have a single screen or a dual screen. The scintillating glass ceramics may be used for either a front screen or a back screen. The scintillating glass ceramics may be used for high energy x-ray applications including for energies of about 0.3 to about 20 MeV. A build-up layer may be attached to the scintillating glass ceramics for high energy applications. The scintillating glass ceramics may include a glass matrix hosting luminescent centers and light scattering centers. The materials used for the luminescent centers and light scattering centers may be the same or different. The scintillating glass ceramics may be coated onto a glass substrate.

IPC Classes  ?

• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• G01T 1/202 - Measuring radiation intensity with scintillation detectors the detector being a crystal

Abstract

Disclosed is a compound of formula (I) in which R1, R2, R3, X1, X2, X2', X3, X4, ring A, m, n, and o are as described herein. The compound of formula (I) is useful for treating a disorder associated with androgen receptor malfunction, such as a hyperproliferative disorder, in a subject in need thereof.

IPC Classes  ?

• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 35/00 - Antineoplastic agents
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

The present disclosure relates to a microfluidic device for simulating the structure and function of an in vivo tissue barrier. Specifically, the present disclosure relates to a microfluidic device that can be used as a model for new drug development and toxicity assessment and the like by simulating the structure and function of a two-dimensional-three-dimensional connective tissue barrier or a three-dimensional tissue barrier and thus replacing animal models, a method of culturing cells in the microfluidic device, and a method of simulating an organ or a body part using the microfluidic device.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

Methods are provided that involve the intentional and controlled precipitation of a drug or active agent, or a reduction of solubility of a polymer or other film-forming component of a formulation, or a combination of both methods, to improve the processes for making microneedles or other objects by casting into molds and the resulting parts produced by casting. The selective reduction in solubility of formulation components solves many problems associated with the casting of polymer formulations into molds. The methods are preferably adapted for making microneedles of biodegradable polymer and drug composites, and may also be used to produce other solid objects formed by casting into molds of compositions containing polymers and active agents.

IPC Classes  ?

• A61M 5/162 - Needle sets, i.e. connections by puncture between reservoir and tube

Abstract

A wearable device for administering an electroretinography examination to a wearer can have a housing that defines a first and a second compartment. Each of the first and second compartments can comprise: a stimulation light source, a focal light source, an active electrode that is configured to engage skin of the wearer, and a reference electrode that is spaced from the active electrode and configured to engage skin of the wearer. A processor can be communicatively coupled to the stimulation light source, the active electrode, and the reference electrode of each of the first and second compartments of the housing. A memory can be in communication with the processor. The device can perform a method comprising: causing the stimulation light source of the first compartment to flash; and storing a signal from the active electrode of the first compartment. The housing can further comprise a ground electrode.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/15 - Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection

Abstract

Disclosed are films and materials comprising poly(alkylene glycol)-chitosan and/or chitin-poly(glucuronic acid) and chitosan and/or chitin-poly(glucuronic acid). Methods of making such films, particularly involving thermally crosslinking poly(glucuronic acid) with chitosan, are disclosed.

IPC Classes  ?

• B29C 70/02 - Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising combinations of reinforcements and fillers incorporated in matrix material, forming one or more layers, with or without non-reinforced or non-filled layers
• C08L 5/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof

Abstract

The present disclosure is directed to metal organic framework materials and uses for such metal organic framework materials. According to one embodiment, a metal organic framework material may include zinc ions, one or more triazoles, and one or more imidazoles. At least a portion of the zinc ions may be coordinated by the triazoles and the imidazoles such that at least a portion of the metal organic framework material forms a crystalline structure belonging to a monoclinic crystal system.

IPC Classes  ?

• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material

Abstract

The present disclosure relates to current source inverters (CSIs), and in particular to soft-switching current source inverters (SSCSIs). An exemplary CSI comprises a first CSI bridge, a second CSI bridge, a DC-link inductor, and a resonant tank. The first CSI bridge can be operatively connected to a first power bank. The second CSI bridge can be operatively connected to a second power bank. The DC-link inductor can be connected in series between the first and second CSI bridges. The resonant tank can be connected in parallel with the DC-link inductor.

IPC Classes  ?

• H02M 7/162 - Conversion of AC power input into DC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only in a bridge configuration
• H02M 7/48 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
• H02M 7/521 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only in a bridge configuration
• H02M 7/523 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only with LC-resonance circuit in the main circuit

Abstract

Compositions for delivering nucleic acids to cells or tissue microenvironments are provided. In one embodiment, the compositions are lipid nanoparticle compositions formulated to have reduced splenic and hepatic clearance. It has been discovered that the chemical composition of lipid nanoparticles significantly influences the natural trafficking of the lipid nanoparticles. More specifically, it has been discovered that conformationally constrained ionizable lipids can modify the tropism and clearance profile of lipid nanoparticles without the need of a targeting ligand. It has also been discovered that tropism of the disclosed lipid nanoparticles is size-independent.

IPC Classes  ?

• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61P 37/02 - Immunomodulators
• C07C 219/16 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by an inorganic acid or a derivative thereof
• C07C 229/08 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
• C07C 271/22 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• C07D 231/56 - BenzopyrazolesHydrogenated benzopyrazoles
• C07D 239/42 - One nitrogen atom
• C07D 241/24 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 241/40 - Benzopyrazines
• C07D 295/088 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
• C07D 513/04 - Ortho-condensed systems
• C07F 5/02 - Boron compounds

Abstract

An exemplary embodiment provides a current sensor comprising a printed circuit board (PCB), a Rogowski coil, and a controller. The PCB can comprise an aperture configured to receive a conductor carrying an alternating electrical current. The Rogowski coil can be positioned on the PCB along a perimeter of the aperture. The controller can be in electrical communication with the Rogowski coil and configured to generate an output signal indicative of the alternating electric current carried by the conductor. The current sensor can be configured to measure the alternating electric current relative to a full scale at a resolution of 1000:1 and at an accuracy within 1%, wherein the full scale can range over 5000:1.

IPC Classes  ?

• G01R 15/18 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers
• G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof
• H01F 5/00 - Coils

Abstract

The present disclosure provides a composition. The composition includes (i) an ethylene-based polymer; (ii) an organic peroxide, (iii) a triorganoaminophosphine, and (iv) a protic acid-source compound ("PASC") selected from a protic acid, a protic acid-generator compound ("PAGC"), and combinations thereof. The present disclosure also provides a coated conductor. The coated conductor includes a conductor and a coating on the conductor, the coating containing a composition including (i) an ethylene-based polymer; (ii) an organic peroxide, (iii) a triorganoaminophosphine, and (iv) a protic acid-source compound ("PASC") selected from a protic acid, a protic acid-generator compound ("PAGC"), and combinations thereof.

IPC Classes  ?

• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08K 5/14 - Peroxides
• C08K 5/36 - Sulfur-, selenium-, or tellurium-containing compounds
• C08K 5/50 - Phosphorus bound to carbon only
• C08K 5/5399 - Phosphorus bound to nitrogen
• C08L 23/04 - Homopolymers or copolymers of ethene
• C09D 123/04 - Homopolymers or copolymers of ethene
• H01B 3/44 - Insulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances plasticsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances resinsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances waxes vinyl resinsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances plasticsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances resinsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances waxes acrylic resins

Abstract

An embodiment of the disclosed technology provides an isolation device for isolating clustered particles. The isolation device can include an inlet configured to receive a fluid and an outlet configured to output the fluid. The fluid can include a plurality of non-clustered particles and a plurality of clustered particles. The isolation device can include a plurality of microwells. Each microwell can have a plurality of sidewalls and a bottom surfacing having a meshed trapping region. The meshed trapping region can capture the plurality of clustered particles while allowing the non-clustered particles to pass. The outputted fluid can include the plurality of non-clustered particle and be substantially free of the plurality of clustered particles.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/07 - Animal cells or tissues
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/078 - Cells from blood or from the immune system
• C12N 5/09 - Tumour cells

Abstract

Disclosed herein are membranes comprising: porous substrate; and two or more graphene oxide (GO) sheets disposed on the porous substrate, each GO layer comprising a plurality of GO flakes, each GO flake comprising a planar graphene structure with oxygen moieties extending therefrom, wherein the membrane, when a pressure from 10 bar to 50 bar of transmembrane pressure is applied from 1 hour to 48 hours, has an aqueous flux wherein the aqueous flux changes by 5% or less while the pressure is applied. The membranes can also include an intercalating agent disposed between the two or more GO sheets, the intercalating agent interacting with each GO sheet, wherein the intercalating agent provides a non-covalent stabilization of the two or more GO sheets. Also disclosed herein are methods of making and using the same and systems for implementing the same.

IPC Classes  ?

• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• C01B 32/198 - Graphene oxide
• D21C 11/00 - Regeneration of pulp liquors

Abstract

In a method of making a material, a bismaleimide system is heated to generate a bismaleimide liquid (110). The bismaleimide liquid is degassed (114) to generate a degassed bismaleimide liquid. At least one of high speed shear mixing and probe sonication is performed to the degassed bismaleimide liquid to generate a highly mixed bismaleimide liquid phase (112). The highly mixed bismaleimide liquid phase is cured (116). A bismaleimide product is made by heating a three component bismaleimide system to generate a bismaleimide liquid, which is degassed in a 30 mbar vacuum until no new visually perceptible bubbles are detected. The degassed liquid is high speed shear mixed at a speed of 3500 RPM for 10 minutes to generate a highly mixed bismaleimide liquid phase, which is cured to make the bismaleimide product. A substance includes cured bismaleimide having an impact strength in a range of 56 kJ/m2 to 82 kJ/m2.

IPC Classes  ?

• C08F 2/02 - Polymerisation in bulk
• C08J 5/00 - Manufacture of articles or shaped materials containing macromolecular substances
• C08K 3/04 - Carbon
• C08K 7/10 - Silicon-containing compounds

Abstract

An example fluid system can include a fluid noise suppressor having a resilient insert having an outer surface; wherein the resilient insert can be operable to dampen a fluctuation of a total pressure about a mean static pressure, providing effective noise reduction that without the resilient insert, would have occurred in the flowing fluid with the fluctuation; and wherein the mean static pressure can be between about 100 psig to about 10,000 psig.

IPC Classes  ?

• F16L 55/04 - Devices damping pulsations or vibrations in fluids
• F16L 55/045 - Devices damping pulsations or vibrations in fluids specially adapted to prevent or minimise the effects of water hammer

Abstract

The disclosure provides methods and compositions to digitally profile biological activity by detecting the activity of at least two bio markers using protease activity sensors or biocomparators.

IPC Classes  ?

• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
• C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

In a joint movement device (100) for selective flexion and extension of a joint (20), a tendon (120) is disposed adjacent to the first and second joint members. A tendon securing device (112) is secured to the second joint member (12), the tendon (120) being secured to the tendon securing device (112). At least one phalange ring (110) is secured to a joint member and includes a tending routing mechanism (113) configured to route the tendon through the phalange ring (110). An actuator (140) is coupled to the tendon (120) and pulls the tendon (120) inwardly to cause the joint (20) to flex. An elastic member (130) is coupled to the phalange ring (110) and tendon securing device (112) and applies an extension force thereto, thereby causing the joint (20) to extend when the actuator (140) releases the tendon (120).

IPC Classes  ?

• A61F 2/58 - ElbowsWrists

Abstract

A probe part (100) includes a base member (110) defining a first bore (112). A first elongated elastic member (120) includes a near end (126) secured to the base member (110) and extends therefrom to a far end (128) and defines a channel (125) in communication with the first bore (112) and that runs lengthwise with the first elongated elastic member (120). A first tendon (130) has a first end and an opposite second end that is secured to the first elongated elastic member (120) adjacent to the far end (128). The first tendon (130) runs through the channel (125) adjacent the first side (122) and exits through the first bore (112) exiting outwardly therefrom. Applying tension to the first tendon (130) causes the first elongated elastic member (120) to bend in the direction of the first side (122).

IPC Classes  ?

• A61B 1/005 - Flexible endoscopes
• A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
• A61B 17/29 - Forceps for use in minimally invasive surgery

Abstract

Lipid nanoparticles and compositions thereof are disclosed herein. An exemplary nanoparticle composition includes an ionizable lipid, a phospholipid, a PEG-lipid, and a cholesterol modified with a hydroxyl group near the D-sterol ring. The disclosed nanoparticle compositions can target liver Kupffer cells and endothelial cells more preferentially than hepatocytes which should be beneficial in treating liver diseases in which dysfunctional Kupffer cells and endothelial cells are involved in disease pathogenesis.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Abstract

The present disclosure provides a composition. The composition includes: (i) an ethylene-based polymer; (ii) an organic peroxide, (iii) a triorganophosphine, and (iv) a protic acid-source compound ("PASC") selected from a protic acid, a protic acid-generator compound ("PAGC"), and combinations thereof. The triorganophosphine has the Structure (1): Structure (1) wherein R1, R2, and R3 each is independently selected from a C1-C40 hydrocarbyl group, a C1-C40 heterohydrocarbyl group, and combinations thereof; with the proviso that the phosphorus atom is bound to a carbon atom in each of R1, R2, and R3.

IPC Classes  ?

• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08K 5/00 - Use of organic ingredients
• C08K 5/14 - Peroxides
• C08K 5/50 - Phosphorus bound to carbon only
• C08L 23/04 - Homopolymers or copolymers of ethene
• H01B 3/30 - Insulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances plasticsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances resinsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances waxes
• H01B 7/02 - Disposition of insulation

Abstract

The present disclosure provides a composition. The composition includes (i) an ethylene-based polymer; (ii) an organic peroxide, (iii) a phosphine oxide, and (iv) a protic acid-source compound ("PASC") selected from a protic acid, a protic acid-generator compound ("PAGC"), and combinations thereof. The present disclosure also provides a coated conductor. The coated conductor includes a conductor and a coating on the conductor, the coating containing a composition including (i) an ethylene-based polymer; (ii) an organic peroxide, (iii) a phosphine oxide, and (iv) a protic acid-source compound ("PASC") selected from a protic acid, a protic acid-generator compound ("PAGC"), and combinations thereof.

IPC Classes  ?

• C08F 4/34 - Per-compounds with one peroxy-radical
• C08K 5/5313 - Phosphinic compounds, e.g. R2=P(:O)OR'
• H01B 7/00 - Insulated conductors or cables characterised by their form

Abstract

: Compositions and methods for pharmacodynam-ic monitoring of immunotherapy are provided herein. The com-positions include an immunotherapeutic agent linked to protease substrates. Upon administration, the compositions target to sites of disease where proteases are upregulated during responsive im-munotherapy and subsequently cleave the attached substrates. Cleavage fragments are detected in a sample from the body and detection of the fragments is indicative of an effect of the im-munotherapeutic agent.WO 2020/055952 Al 11111 1111111111111111 ON IN 11111 11 II II III 11111 11111 Ell 11111 III I II 11E11E1111 111111Declarations under Rule 4.17:¨ as lo applicant's enlillement to apply for and be granted apatent (Rule 4.1700¨ as to the applicant's entitlement to claim the priority of theearlier application (Rule 4.17(iii))Published:¨ with international search report (Art. 21(3))Date Recue/Date Received 2021-03-11

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• A61P 35/00 - Antineoplastic agents
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes

Abstract

According to one embodiment, a millimeter-wave (mm-wave) frontend integrated circuit includes an array of mm-wave transceivers, where each of the mm-wave transceivers transmits and receives coherent mm-wave signals with variable amplitudes and phase shifts. The mm-wave frontend IC chip further includes a wideband frequency synthesizer coupled to the mm-wave transceivers. The full-based or wideband frequency synthesizer generates and provides a local oscillator (LO) signal to each of the mm-wave transceivers to enable the mm-wave transceiver to mix, modulate, and/or demodulate mm-wave signals. The array of mm-wave wideband transceivers and the wideband frequency synthesizer may be implemented within a single IC chip as a single mm-wave frontend IC chip or package.

IPC Classes  ?

• H03B 5/12 - Generation of oscillations using amplifier with regenerative feedback from output to input with frequency-determining element comprising lumped inductance and capacitance active element in amplifier being semiconductor device
• H03L 7/099 - Details of the phase-locked loop concerning mainly the controlled oscillator of the loop
• H04B 1/00 - Details of transmission systems, not covered by a single one of groups Details of transmission systems not characterised by the medium used for transmission
• H04B 1/403 - Circuits using the same oscillator for generating both the transmitter frequency and the receiver local oscillator frequency
• H04W 88/06 - Terminal devices adapted for operation in multiple networks, e.g. multi-mode terminals

Abstract

The invention is an improved method of making an improved carbon molecular sieve (CMS) membrane in which a precursor polymer (e.g., polyimide) is pyrolyzed at a pyrolysis temperature to form a CMS membrane that is cooled to ambient temperature (about 40°C or 30°C to about 20°C). The CMS membrane is then reheated to a reheating temperature less than the pyrolysis temperature to form the improved CMS membrane. The improved CMS membranes have shown an improved combination of selectivity and permeance as well as stability for separating hydrogen from gas molecules (e.g., methane, ethane, propane, ethylene, propylene, butane, carbon dioxide, nitrogen, butylene, and combinations thereof).

IPC Classes  ?

• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 71/02 - Inorganic material

Abstract

The invention is an improved method of making an improved carbon molecular sieve (CMS) membrane in which a precursor polymer (e.g., polyimide) is pyrolyzed at a pyrolysis temperature to form a CMS membrane that is cooled to ambient temperature (about 40°C or 30°C to about 20°C). The CMS membrane is then reheated to a reheating temperature of at least 250°C to 400°C to form the improved CMS membrane. The CMS have a novel microstructure as determined by Raman spectroscopy. The improved CMS membranes have shown an improved combination of selectivity and permeance as well as stability for separating light hydrocarbon gas molecules such as C1 to C6 hydrocarbon gases (e.g., methane, ethane, propane, ethylene, propylene, butane, butylene).

IPC Classes  ?

• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 71/02 - Inorganic material
• D01F 9/24 - Carbon filamentsApparatus specially adapted for the manufacture thereof by decomposition of organic filaments from polyaddition, polycondensation or polymerisation products from macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

Methods for controlling brain activity in a subject are described herein. An example method can include delivering a stimulus to the subject, wherein the stimulus induces neural activity in the subject's brain and modulates expression of at least one soluble mediator of cellular activity (such as, for example, a cytokine, chemokine, and/or growth factor) within the subject, and the stimulus is delivered to the subject for less than one hour.

IPC Classes  ?

• A61B 17/00 - Surgical instruments, devices or methods
• A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61N 1/40 - Applying electric fields by inductive or capacitive coupling
• A61N 5/06 - Radiation therapy using light

Abstract

A hydrodynamic barrier device including: a plurality of outlets disposed on a surface; a plurality of inlets dispersed among the plurality of outlets and disposed on the surface; and at least one pump in fluid communication with the plurality of outlets and the plurality of inlets, the at least one pump configured to simultaneously pump an operating fluid out of the plurality of outlets and pull the operating fluid back through the plurality of inlets to create a hydrodynamic barrier on the surface.

IPC Classes  ?

• B01L 99/00 - Subject matter not provided for in other groups of this subclass
• G01N 13/00 - Investigating surface or boundary effects, e.g. wetting powerInvestigating diffusion effectsAnalysing materials by determining surface, boundary, or diffusion effects

Abstract

The present application provides materials and methods for treating hemoglobinopathies. More specifically, the application provides methods for producing progenitor cells that are genetically modified via genome editing to increase the production of fetal hemoglobin (HbF), as well as modified progenitor cells (including, for example, CD34+ human hematopoietic stem cells) producing increased levels of HbF, and methods of using such cells for treating hemoglobinopathies such as sickle cell anemia and ß-thalassemia.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

A carbon molecular sieve (CMS) membrane having improved separation characteristics for separating olefins from their corresponding paraffins is comprised of carbon with at most trace amounts of sulfur and a group 13 metal. The CMS membrane may be made by pyrolyzing a precursor polymer devoid of sulfur in which the precursor polymer has had a group 13 metal incorporated into it, wherein the metal is in a reduced state. The pyrolyzing for the precursor having the group 13 metal incorporated into it is performed in a nonoxidizing atmosphere and at a heating rate and temperature such that the metal in a reduced state (e.g., covalently bonded to carbon or nitrogen or in the metal state).

IPC Classes  ?

• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/06 - Flat membranes
• B01D 69/08 - Hollow fibre membranes
• B01D 69/14 - Dynamic membranes
• B01D 71/02 - Inorganic material
• B01D 71/64 - PolyimidesPolyamide-imidesPolyester-imidesPolyamide acids or similar polyimide precursors
• C07C 7/144 - Purification, separation or stabilisation of hydrocarbonsUse of additives using membranes, e.g. selective permeation

Abstract

A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.

IPC Classes  ?

• A61K 38/36 - Blood coagulation or fibrinolysis factors
• A61P 7/04 - AntihaemorrhagicsProcoagulantsHaemostatic agentsAntifibrinolytic agents
• C07K 14/745 - Blood coagulation or fibrinolysis factors
• C07K 14/755 - Factors VIII
• C12N 15/12 - Genes encoding animal proteins
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/867 - Retroviral vectors

Abstract

Disclosed herein are compositions and methods for identifying materials suitable for functional delivery of a bioactive agent to a target tissue. These compositions and methods have the advantage of simultaneously screening a library of materials for the ability to deliver a bioactive agent to a cell, tissue, or organ. The compositions and methods can also be used to confirm that the agent is delivered in a manner sufficient for function of the agent.

IPC Classes  ?

• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

Separable microneedle arrays and microneedle patches are provided that may achieve sustained release of drug. The microneedle arrays may include one or more features that facilitate separation of the microneedles, such as a bubble structure. The microneedle arrays may include an effervescent material.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/46 - Pills, lozenges or tablets effervescent
• A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A coating for conversion of formaldehyde to carbon dioxide includes an alcohol/aldehyde oxidase and a formate oxidase immobilized on a solid particulate support; and a latex binder.

IPC Classes  ?

• C09D 5/00 - Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects producedFilling pastes
• C09D 7/65 - Additives macromolecular
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase

Abstract

Disclosed herein are novel variants of clotting factors VII, VIII, and IX and their use, for example, in methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• C07K 14/745 - Blood coagulation or fibrinolysis factors
• C07K 14/755 - Factors VIII
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/86 - Viral vectors

Abstract

Embodiments of the present disclosure can include a hybrid transformer system comprising an electrical voltage transformer comprising: a high-voltage winding, the high-voltage winding comprising a first end and a second end, the first end having a lower voltage than the second end; a plurality of taps disposed proximate the first end of the high-voltage winding; a multi-level converter coupleable to the plurality of taps of the electrical voltage transformer, the multi-level converter configured to simultaneously control voltage injection and VAR injection to the high-voltage winding of the electrical voltage transformer; and a controller electrically coupleable to the multi-level converter, such that when the multi-level converter is coupled to the plurality of taps of the electrical voltage transformer, the controller is configured to selectively inject at least one of VARs or voltage to the high-voltage winding of the electrical voltage transformer.

IPC Classes  ?

• H01F 38/14 - Inductive couplings

Abstract

Described herein are FasL-engineered biomaterials, as well as methods of making and using such FasL-engineered biomaterials, such as for immunomodulation, such as for inducing immunosuppression and specific immune tolerance, such as for preventing or reducing the risks of rejection of cellular or tissue grafts and/or the treatment of autoimmune disorders such as Type I diabetes. In specific embodiments, the FasL-engineered biomaterials are biotinylated microgels bound to SA-FasL.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C12M 3/02 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
• C12N 5/22 - Human cells
• C12N 15/09 - Recombinant DNA-technology
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Disclosed herein are synthetic hydrogel useful for the generation, storage and administration of cellular structures such as spheroids and organoids.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• A61L 27/22 - Polypeptides or derivatives thereof
• A61L 27/52 - Hydrogels or hydrocolloids
• C12N 5/074 - Adult stem cells
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• C12N 5/0789 - Stem cellsMultipotent progenitor cells

Abstract

A medical device reduces the risk of operating room fires caused by light sources by shielding the illuminated light cable from directly interacting with surgical drapes or patient skin. The device includes a silicone housing that mates circumferentially over existing endoscopic light cables and a thermal insulator can be positioned over the light emitting tip of the cable.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres