The present invention relates to a composition for alleviating male menopause symptoms, the composition containing probiotics selected from among eight novel strains of probiotics, that is, two strains of Lactis paracasei, four strains of Lactis plantarum, one strain of Lymosilactobacillus fermentum, and one strain of Streptococcus thermophilus. The probiotics are characterized by enhancing the secretion of the male hormone testosterone, and enhancing the expression of a gene, selected from among 3β-hydroxysteroid dehydrogenase I (3β-HSD-I), 3β-hydroxysteroid dehydrogenase VI (3β-HSD-VI), androgen receptor (AR), and steroidogenic acute regulatory protein (StAR), involved in testosterone secretion.
Provided is a composition for preventing and treating lipid-related metabolic diseases, the composition comprising, as an active ingredient, Lactobacillus plantarum ATG-K2 or Lactobacillus plantarum ATG-K6 isolated from fermented vegetables.
A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
The present invention relates to a composition containing a Lactobacillus reuteri ATG-F4 strain as an active ingredient for preventing, alleviating, or treating side effects of cachexia or chemotherapy.
A novel strain, Lactobacillus paracasei ATG-E1 (Accession No. KCTC 14245BP), and a composition containing the same for preventing or treating respiratory diseases which are caused by fine particulate matter. The Lactobacillus paracasei ATG-E1 strain reduces the number of immune cells bronchoalveolar and lung tissues and inhibits the expression of inflammatory cytokines such as interleukin-17A (IL-17A), tumor necrosis factor-α (TNF-α), macrophage inflammatory protein 2 (MIP2), C-X-C motif chemokine ligand 1 (CXCL-1), macrophage inflammatory protein-α (MIP-1α) or interleukin-6 (IL-6). Therefore, the Lactobacillus paracasei ATG-E1 strain can be used for a treatment or health functional food for various respiratory diseases such as acute and chronic bronchitis, catarrhal bronchitis, bronchitis obliterans, inflammatory bronchitis, bronchial asthma, atopic asthma, non-atopic asthma, atopic IgE-mediated asthma, allergic asthma, non-allergic asthma, chronic bronchoconstriction, acute bronchoconstriction, chronic obstructive pulmonary disease, bronchial adenoma, pulmonary tuberculosis, emphysema, lung abscess, pulmonary fibrosis, lung cancer, airway cancer, bronchoalveolar cancer, and bronchial cancer.
The present invention relates to a novel lactobacillus fermentum ATG-V5 strain or a composition for enhancing immunity, comprising same. The Lactobacillus fermentum ATG-V5 strain of the present invention has no cytotoxicity, and has the effect of enhancing immunity, such as increasing the amounts of nitric oxide (NO), interleukin 6 (IL-6) and tumor necrosis factor (TNF) secretion and phagocytosis of macrophages, reducing the amount of interleukin 1β (IL-1β) secretion of macrophages, increasing the cell viability of splenocytes, and increasing the amount of antibodies and cytokines secretion in the blood, and thus the strain can be effectively used as a material for a composition and a health functional food for enhancing immunity, and the composition and health functional food can be effectively used in enhancing individual immune activity. In addition, a health functional food comprising the food composition is also effective in enhancing individual immune activity.
Provided is a composition for preventing and treating lipid-related metabolic diseases, the composition comprising, as an active ingredient, Lactobacillus plantarum ATG-K2 or Lactobacillus plantarum ATG-K6 isolated from fermented vegetables.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Lactobacillus paracaseiLactobacillus paracasei ATG-E1 strain (Accession No: KCTC 14245BP) and a composition comprising same for preventing or treating a respiratory disease, wherein the respiratory disease is induced by fine dust. The Lactobacillus paracasei ATG-E1 strain may, by reducing the number of immune cells in bronchial alveoli and lung tissue, inhibit expression of inflammatory cytokines, such as interleukin-17A (IL-17A), tumor necrosis factor-α (TNF-α), macrophage inflammatory protein 2 (MIP2), C-X-C motif chemokine ligand 1 (CXCL-1), MIP2 (macrophage inflammatory protein-α) (MIP-1α), or interleukin-6 (IL-6), and thus may be used as a therapeutic agent or health functional food for various respiratory diseases including acute(chronic) bronchitis, catarrhal bronchitis, obstructive bronchitis, inflammatory bronchitis, bronchial asthma, atopic asthma, nonatopic asthma, atopic IgE-mediated asthma, allergic asthma, nonallergic asthma, chronic bronchoconstriction, acute bronchoconstriction, chronic obstructive pulmonary disease, bronchial adenoma, pulmonary tuberculosis, pulmonary emphysema, pulmonary abscess, pulmonary fibrosis, lung cancer, tracheal cancer, bronchoalveolar carcinoma, and bronchogenic carcinoma.
Lactobacillus fermentumLactobacillus fermentum ATG-V5 strain of the present invention has no cytotoxicity, and has the effect of enhancing immunity, such as increasing the amounts of nitric oxide (NO), interleukin 6 (IL-6) and tumor necrosis factor (TNF) secretion and phagocytosis of macrophages, reducing the amount of interleukin 1β (IL-1β) secretion of macrophages, increasing the cell viability of splenocytes, and increasing the amount of antibodies and cytokines secretion in the blood, and thus the strain can be effectively used as a material for a composition and a health functional food for enhancing immunity, and the composition and health functional food can be effectively used in enhancing individual immune activity. In addition, a health functional food comprising the food composition is also effective in enhancing individual immune activity.
The present invention relates to a composition for the prevention or treatment of sarcopenia, the composition including a Lactobacillus reuteri ATG-F4 strain. More specifically, the strain exhibits an effect of improving muscle rehabilitation and motor ability by increasing the muscle mass in skeletal muscles, thereby being suitably used as an ingredient for compositions for the prevention or treatment of sarcopenia or muscular atrophy.
The present invention relates to a novel Bifidobacterium longum ATG-F5 strain. The F5 strain is a functional beneficial bacterium which is safe from antibiotic resistance, improves skin health through antibacterial activity against the skin pathogen Cutibacterium acnes, an antioxidant effect on radicals, skin barrier improvement, and anti-inflammatory effects, and enhances skin beauty through a skin whitening function, a wrinkle improvement function, and a dry skin alleviation function. The strain may be used in a cosmetic composition or health functional food.
Gardnerella vaginalis, which are vaginitis pathogens, and thus can be easily used as a composition for the treatment of bacterial vaginosis, vaginal candidiasis, etc., or as a functional health food for the prevention or amelioration of these diseases.
The present invention relates to a composition for preventing or treating lipid-related metabolic diseases, the composition comprising, as an active ingredient, Lactobacillus plantarum ATG-K2 or Lactobacillus plantarum ATG-K6 isolated from fermented vegetables.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
13.
Lactobacillus plantarum strain ATG-K2, ATG-K6 or ATG-K8, and composition for preventing or treating vaginitis comprising same
Gardnerella vaginalis, which are vaginitis pathogens, and thus can be easily used as a composition for the treatment of bacterial vaginosis, vaginal candidiasis, etc., or as a functional health food for the prevention or amelioration of these diseases.
Lactobacillus reuteri ATG-F4 strain having function of enhancing dopamine secretion and pharmaceutical composition comprising same for prevention or treatment of psychopathy
Lactobacillus reuteri ATG-F4 strain (Accession number KCTC13717BP) is proposed. The strain has the function of enhancing dopamine secretion, and thus can be used as a pharmaceutical composition or a functional health food for the prevention or amelioration of mental illnesses, such as memory disorder, depressive disorder, generalized anxiety disorder, bipolar disorder, and the like, as well as Parkinson's disease, or can be used as a very effective composition for the improvement of memory or cognitive function. Moreover, the strain exhibits anti-inflammatory efficacy of upregulating the expression of IL-10 (interleukin-10) and inhibiting the generation of nitric oxide (NO) and is not resistant to antibiotics, and can thus be readily applied to a variety of foods having health improvement effects.
Lactobacillus reuteriLactobacillus reuteri ATG-F4 strain for prevention or treatment of sarcopenia. More specifically, the strain exhibits an effect of improving muscle rehabilitation and motor ability by increasing the muscle mass in skeletal muscles and as such, can be used in a composition for prevention or treatment of sarcopenia or muscular atrophy.
Cutibacterium acnesCutibacterium acnes, an antioxidant effect on radicals, skin barrier improvement, and anti-inflammatory effects, and enhances skin beauty through a skin whitening function, a wrinkle improvement function, and a dry skin alleviation function. The strain can be used in a cosmetic composition or health functional food.
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
17.
NOVEL LACTOBACILLUS REUTERI ATG-F4 STRAIN HAVING FUNCTION OF ENHANCING DOPAMINE SECRETION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTION OR TREATMENT OF PSYCHOPATHY
The present invention relates to a Lactobacillus reuteri ATG-F4 strain (accession number KCTC13717BP). Having the function of enhancing dopamine secretion, the strain is available in a pharmaceutical composition or health functional food for prevention or alleviation of psychopathy, such as memory impairment, depressive disorder, generalized anxiety disorder, bipolar disorder, etc., and Parkinson's disease, or in a composition very effective for improving memory or cognitive function. Furthermore, the strain exhibits the anti-inflammatory efficacy of upregulating the expression of Interleukin-10 (IL-10) and suppressing the generation of nitric oxide (NO) and is free of resistance to antibacterial agents and as such, can be readily applied to various foods that have health improvement effects.
Candida albicansGardnerella vaginalisGardnerella vaginalis which are causative bacteria of vaginitis, and thus can be easily used as a composition for treating bacterial vaginitis, candida vaginitis, etc., or as a health functional food for preventing or ameliorating these diseases.
Lactobacillus plantarum HAC01 strain having anti-inflammatory efficacy and metabolic disease improving efficacy, a probiotic preparation, an anti-inflammatory composition, and a health food composition for improving a metabolic disease, which comprises, as an active ingredient, at least one selected from the group consisting of the strain, a culture product of the strain, a concentrate of the culture product, and a dried material of the culture product.
A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
HANDONG GLOBAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (Republic of Korea)
Inventor
Holzapfel, Wilhelm
Shin, Hyeunkil
Hyun, Changki
Ji, Yosep
Park, Soyoung
Kang, Jihee
Abstract
The present invention relates to a Lactobacillus plantarum HAC01 strain having anti-inflammatory efficacy and metabolic disease alleviating efficacy, and to a probiotic preparation, an anti-inflammatory composition, and a metabolic disease alleviating health food composition, which contain, as an active ingredient, at least one selected from the group consisting of the strain, a culture product of the strain, and a concentrate and a dried material of the culture product.
patents
