Method and system embodiments for controlling power provided to a device implantable in a subject are described. In some embodiments, a method is performed at the implantable device to receive, from an interrogator, powering ultrasonic waves having a wave power. Then, energy from the powering ultrasonic waves is converted into an electrical signal to power the implantable device. Information that indicates whether more power or less power should be transmitted to the implantable device is transmitted to the interrogator.
Provided herein are stimulation devices and methods of use thereof to generate a focused electric field for targeted electrical stimulation of muscle. The stimulation devices described herein may comprise a plurality of current sources electrically coupled to a plurality of electrodes that can deliver direct stimulation to muscle or an organ comprising a muscle. The current sources may be connected in series through the muscle or the organ comprising the muscle. Using the stimulation devices described herein, currents delivered to the electrodes can be independent of one another and adjusted to generate a focused electric field.
Provided herein are housings and cradles for cranially-mounted implantable neurostimulators (INS). The INS housing can include an external surface having a curved profile that corresponds to the curvature of a human skull. The INS housing may include a lead connection port and one or more attachment portions configured to enclose a control circuit for neurostimulation. The INS may be contained within a cradle configured to be implanted in the skull. Due to the low profile of the INS housing, whether implanted in the skull within the cradle or itself implanted to the skull, may not protrude from the surface of the skull and thus may not introduce additional pressure at the skull.
An implantable device may include a housing with an acoustic window, a piezoelectric transducer, and a fluid filler. The piezoelectric transducer and the fluid filler may be contained within the housing. The transducer may be attached to an interior surface of the acoustic window such that ultrasonic waves passing through the acoustic window do not pass through a fluid before reaching the piezoelectric transducer. The acoustic window and the piezoelectric transducer may be configured to acoustically resonate at approximately the same resonance frequency. The fluid filler may have an acoustic impedance that is not approximately equal to an acoustic impedance of the piezoelectric transducer.
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
Provided herein are cutting template devices and methods of use thereof for preparing a skull for implantation of a pulse generator (IPG) for deep brain stimulation. The cutting templates described herein may comprise a coarse texture and/or one or more protruding members to minimize movement of the cutting template when placed against an otherwise-slippery surface of the skull. The body of the cutting templates may be sized to correspond with a profile of an IPG and may include one or more curvatures corresponding with the anatomic curvature(s) of the skulk
Provided herein are lead and stylet systems and methods of using the sty let to implant the lead into the brain. The leads may be used for deep brain stimulation (DBS) and may be connected to a cranially mounted implantable pulse generator (IPG) of a DBS sy stem. The lead may comprise a lumen configured to removably house the stylet to assist in implanting electrodes disposed on the lead in the brain. The lead and stylet systems described herein may allow for minimal excess lead length between the implantation site of the lead in the brain and the IPG (e.g., implanted in the skull).
Provided herein are lead fixation devices and methods of using the lead fixation devices to mount stimuiation leads to the skuil. The lead fixation devices may be used to mount stimulation leads for deep brain stimulation. The lead fixation devices may maintain a relative position of the stimulation lead while allowing for axial float of the lead. The lead fixation devices can comprise one or more flexures or bellows couplings to maintain the position of the stimulation lead while isolating forces acting on the lead.
A method for improving communication with an implantable device in a subject can include determining, by a computing system, for a plurality of sampling times, a current position and a current orientation of an interrogator. The interrogator may include a transducer configured to communicate with the implantable device and an inertial measurement unit. The current position and the current orientation of the interrogator may be determined relative to a target contact location on the subject using interrogator location data received from the inertial measurement unit. The target contact location may be associated with a location of the implantable device in the subject. The computing system may then generate control information indicating to a user how to move the interrogator in order to improve communication with the implantable device based on the target contact location, the current position and current orientation of the interrogator, and the location of the implantable device.
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
H04B 11/00 - Transmission systems employing ultrasonic, sonic or infrasonic waves
H04B 13/00 - Transmission systems characterised by the medium used for transmission, not provided for in groups
An implantable device may include a primary current source electrically coupled to an adjustable voltage source and to a tissue. In order for the implantable device to properly treat the tissue, the voltage across the primary current source may need to exceed a compliance voltage. The implantable device may include auxiliary current sources and a control circuit configured to electrically connect one or more of the auxiliary current sources in parallel with the primary current source if a voltage across the primary current source is less than a compliance voltage for the primary current source. If the voltage across the primary current source is less than the compliance voltage after the auxiliary current sources have been connected, the control circuit may adjust the supply voltage from the adjustable voltage source.
Described herein are implantable closed-loop neuromodulation devices, systems that includes such devices and an interrogator configured to emit ultrasonic waves that power the device, methods of using such devices and systems, and methods of modulating neural activity. The implantable device can include one or more curved members extending from a body. The curved members are configured to at least partially circumscribe a nerve, and include one or more electrode pads. The body includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy; and a computational circuit configured to receive a detection signal based on a detected electrophysiological signal, generate a stimulation signal based on the detection signal, and operate the electrode pads of to emit an electrical pulse to the nerve based on the stimulation signal.
An implantable device may comprise a power management unit configured to receive power from an external power source, one or more sensors, and a memory configured to store data detected by the one or more sensors. The memory may include a first binary storage element electrically coupled to the sensors and to a main power supply line coupled to the power management unit, and a second binary storage element coupled to the first binary data memory storage element and to a retention power supply line connected to the power supply. The device may include a digital circuit configured to determine that the power management unit is not receiving power from the external power source, detect that a predetermined condition has been met, store data collected by the sensors in the second binary data memory storage element, and disconnect the main power supply line from the power supply.
A helical nerve cuff and an implantable device comprising the helical nerve cuff and a body comprising a wireless communication system are described herein. The implantable device can include a body having a wireless communication system; electrodes that can detect an electrophysiological signal transmitted by a nerve or emit an electrical pulse to the nerve; and a helical nerve cuff. Also described are methods of implanting the helical nerve cuff and the implantable device, as well as methods of making the helical nerve cuff and the implantable device.
Described herein are methods and devices for monitoring or modulating an immune system in a subject with cancer, and methods and devices for treating a cancer in a subject. The implanted device can electrically stimulate the splenic nerve of the subject, which can modulate the inflammatory system (for example, by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and/or anti-inflammatory cytokines to increase or decrease inflammation in the subject) and/or activate or increase circulation of one or more immune cells (such as natural killer cells and/or cytotoxic T-cells), for the treatment of cancer. The implanted medical device includes two or more electrodes configured to electrically stimulate the splenic nerve, and may further include an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device.
Method and system embodiments for discovering or tracking a device implantable in a subject using ultrasonic waves are described. The method for tracking the implantable device can include establishing a synchronization state with the implantable device, estimating a location of the implantable device, and determining whether to maintain or to adjust were an ultrasonic beam is being focused based on ultrasonic signal strength. The method for discovering an implantable device powered using ultrasonic waves can include emitting an ultrasonic beam to successively focus on a plurality of focal points, receiving ultrasonic backscatter corresponding to the ultrasonic beam focused on the focal point, and comparing the received ultrasonic backscatter with a predetermined pattern associated with the implantable device to be discovered to generate a score indicating how likely the ultrasonic backscatter comprises the predetermined pattern; and determining a location of the implantable device from based on the scores.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
H02J 50/15 - Circuit arrangements or systems for wireless supply or distribution of electric power using ultrasonic waves
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
15.
Implants using ultrasonic communication for modulating splenic nerve activity
Described herein are methods for monitoring or modulating an immune system in a subject; treating, reducing or monitoring inflammation; monitoring blood pressure; treating hypertension; or administering or adjusting a therapy for inflammation or hypertension in a patient by electrically stimulating the splenic nerve or detecting splenic nerve activity using an implanted medical device. Also described herein are implantable medical devices for performing such methods. The implanted medical device includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device, two or more electrodes in electrical communication with the ultrasonic transducer that are configured to electrically stimulate a splenic nerve or detect a splenic nerve activity, and optionally a splenic nerve attachment member.
An implantable device for measuring an intraocular pressure, and methods of using such a device, are described herein. Also described is a system that includes the implantable device and an external device that wirelessly communicates with the implantable device. To power the implantable device, the external device contacts a surface on or near the eye. By contacting the surface on or near the eye, the external device can artificially alter the intraocular pressure. To avoid this artificial pressure skew, the implantable device is configured to measure the intraocular pressure within the eye after the external device has been removed and store the pressure data in a memory for later transmittal to the external device.
A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.
Methods and systems for low-power communication using ultrasonic waves are described herein. The methods may include receiving, at one or more ultrasonic transducers of an implantable device, ultrasonic waves transmitted by an interrogator; and emitting, from the one or more ultrasonic transducers of the implantable device, ultrasonic backscatter comprising encoded data, wherein the data is encoded into the ultrasonic backscatter by modulating a. frequency of the ultrasonic backscatter. The device may include an ultrasonic transducer configured to receive ultrasonic waves and emit ultrasonic backscatter; a switch configured to modulate a frequency of the emitted ultrasonic backscatter, and a circuit configured to operate the switch to encode data, in the emitted ultrasonic backscatter based on the frequency.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
H02J 50/15 - Circuit arrangements or systems for wireless supply or distribution of electric power using ultrasonic waves
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H04B 11/00 - Transmission systems employing ultrasonic, sonic or infrasonic waves
H04B 13/00 - Transmission systems characterised by the medium used for transmission, not provided for in groups
19.
ULTRASONIC IMPLANT AND SYSTEM FOR MEASUREMENT OF INTRAOCULAR PRESSURE
A device for measuring an intraocular pressure that includes: a pressure sensor configured to measure the intraocular pressure; an ultrasonic transducer electrically coupled to the pressure sensor and configured to receive ultrasonic waves and emit ultrasonic backscatter encoding a pressure measured by the pressure sensor, and a substrate attached to the pressure sensor and the ultrasonic transducer, and configured to interface a surface on or within an eye.
A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
Methods and systems for low-power communication using ultrasonic waves are described herein. The methods may include receiving, at one or more ultrasonic transducers of an implantable device, ultrasonic waves transmitted by an interrogator; and emitting, from the one or more ultrasonic transducers of the implantable device, ultrasonic backscatter comprising encoded data, wherein the data is encoded into the ultrasonic backscatter by modulating a. frequency of the ultrasonic backscatter. The device may include an ultrasonic transducer configured to receive ultrasonic waves and emit ultrasonic backscatter; a switch configured to modulate a frequency of the emitted ultrasonic backscatter, and a circuit configured to operate the switch to encode data, in the emitted ultrasonic backscatter based on the frequency.
H04B 11/00 - Transmission systems employing ultrasonic, sonic or infrasonic waves
H02J 50/15 - Circuit arrangements or systems for wireless supply or distribution of electric power using ultrasonic waves
A61N 1/372 - Arrangements in connection with the implantation of stimulators
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H04B 13/00 - Transmission systems characterised by the medium used for transmission, not provided for in groups
21.
DEVICES AND METHODS FOR TREATING CANCER BY SPLANCHNIC NERVE STIMULATION
Methods, implantable devices, and systems for treating a cancer or inhibiting cancer growth or recurrence in a subject are described herein. Such methods can include electrically stimulating a thoracic splanchnic nerve (such as a greater splanchnic nerve) of the subject with a plurality of electrical pulses emitted from one or more electrodes m electrical communication with the splanchnic nerve, wherein the plurality of electrical pulses triggers one or more action potentials in the splanchnic nerve to increase circulating natural killer (NK) cells in the subject. An implantable device may include one or more electrodes configured to be in electrical communication with a thoracic splanchnic nerve of a subject with cancer, and be configured to operate the one or more electrodes to electrically stimulate the splanchnic nerve with a plurality of electrical pulses that triggers one or more action potentials in the splanchnic nerve that increase circulating NK cells.
Method and system embodiments for operating a device implantable in a subject using ultrasonic waves are described. In some embodiments, a method is performed at the implantable device to receive ultrasonic waves including an operating mode command. Then, the implantable device sets an operating mode of the implantable device to one operating mode from a plurality of predetermined operating modes based on the operating mode command.
Method and system embodiments for discovering or tracking a device implantable in a subject using ultrasonic waves are described. The method for tracking the implantable device can include establishing a synchronization state with the implantable device, estimating a location of the implantable device, and determining whether to maintain or to adjust were an ultrasonic beam is being focused based on ultrasonic signal strength. The method for discovering an implantable device powered using ultrasonic waves can include emitting an ultrasonic beam to successively focus on a plurality of focal points, receiving ultrasonic backscatter corresponding to the ultrasonic beam focused on the focal point, and comparing the received ultrasonic backscatter with a predetermined pattern associated with the implantable device to be discovered to generate a score indicating how likely the ultrasonic backscatter comprises the predetermined pattern; and determining a location of the implantable device from based on the scores.
Method and system embodiments for discovering or tracking a device implantable in a subject using ultrasonic waves are described. The method for tracking the implantable device can include establishing a synchronization state with the implantable device, estimating a location of the implantable device, and determining whether to maintain or to adjust were an ultrasonic beam is being focused based on ultrasonic signal strength. The method for discovering an implantable device powered using ultrasonic waves can include emitting an ultrasonic beam to successively focus on a plurality of focal points, receiving ultrasonic backscatter corresponding to the ultrasonic beam focused on the focal point, and comparing the received ultrasonic backscatter with a predetermined pattern associated with the implantable device to be discovered to generate a score indicating how likely the ultrasonic backscatter comprises the predetermined pattern; and determining a location of the implantable device from based on the scores.
Method and system embodiments for controlling power provided to a device implantable in a subject are described. In some embodiments, a method is performed at the implantable device to receive, from an interrogator, powering ultrasonic waves having a wave power. Then, energy from the powering ultrasonic waves is converted into an electrical signal to power the implantable device. Information that indicates whether more power or less power should be transmitted to the implantable device is transmitted to the interrogator.
A device for measuring an intraocular pressure that includes: a pressure sensor configured to measure the intraocular pressure; an ultrasonic transducer electrically coupled to the pressure sensor and configured to receive ultrasonic waves and emit ultrasonic backscatter encoding a pressure measured by the pressure sensor; and a substrate attached to the pressure sensor and the ultrasonic transducer, and configured to interface a surface on or within an eye.
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A device for measuring an intraocular pressure that includes: a pressure sensor configured to measure the intraocular pressure; an ultrasonic transducer electrically coupled to the pressure sensor and configured to receive ultrasonic waves and emit ultrasonic backscatter encoding a pressure measured by the pressure sensor; and a substrate attached to the pressure sensor and the ultrasonic transducer, and configured to interface a surface on or within an eye.
A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
Methods, implantable devices, and systems for treating a cancer or inhibiting cancer growth or recurrence in a subject are described herein. Such methods can include electrically stimulating a thoracic splanchnic nerve (such as a greater splanchnic nerve) of the subject with a plurality of electrical pulses emitted from one or more electrodes m electrical communication with the splanchnic nerve, wherein the plurality of electrical pulses triggers one or more action potentials in the splanchnic nerve to increase circulating natural killer (NK) cells in the subject. An implantable device may include one or more electrodes configured to be in electrical communication with a thoracic splanchnic nerve of a subject with cancer, and be configured to operate the one or more electrodes to electrically stimulate the splanchnic nerve with a plurality of electrical pulses that triggers one or more action potentials in the splanchnic nerve that increase circulating NK cells.
Methods, implantable devices, and systems for treating a cancer or inhibiting cancer growth or recurrence in a subject are described herein. Such methods can include electrically stimulating a thoracic splanchnic nerve (such as a greater splanchnic nerve) of the subject with a plurality of electrical pulses emitted from one or more electrodes m electrical communication with the splanchnic nerve, wherein the plurality of electrical pulses triggers one or more action potentials in the splanchnic nerve to increase circulating natural killer (NK) cells in the subject. An implantable device may include one or more electrodes configured to be in electrical communication with a thoracic splanchnic nerve of a subject with cancer, and be configured to operate the one or more electrodes to electrically stimulate the splanchnic nerve with a plurality of electrical pulses that triggers one or more action potentials in the splanchnic nerve that increase circulating NK cells.
Described herein are implantable closed-loop neuromodulation devices, systems that includes such devices and an interrogator configured to emit ultrasonic waves that power the device, methods of using such devices and systems, and methods of modulating neural activity. The implantable device can include one or more curved members extending from a body. The curved members are configured to at least partially circumscribe a nerve, and include one or more electrode pads. The body includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy; and a computational circuit configured to receive a detection signal based on a detected electrophysiological signal, generate a stimulation signal based on the detection signal, and operate the electrode pads of to emit an electrical pulse to the nerve based on the stimulation signal.
Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.
A helical nerve cuff and an implantable device comprising the helical nerve cuff and a body comprising a wireless communication system are described herein. The implantable device can include a body having a wireless communication system: electrodes that can detect an electrophysiological signal transmitted by a nerve or emit an electrical pulse to the nerve; and a helical nerve cuff. Also described are methods of implanting the helical nerve cuff and the implantable device, as well as methods of making the helical nerve cuff and the implantable device.
Described herein are methods and devices for monitoring or modulating an immune system in a subject with cancer, and methods and devices for treating a cancer in a subject. The implanted device can electrically stimulate the splenic nerve of the subject, which can modulate the inflammatory system (for example, by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and/or anti-inflammatory cytokines to increase or decrease inflammation in the subject) and/or activate or increase circulation of one or more immune cells (such as natural killer cells and/or cytotoxic T-cells), for the treatment of cancer. The implanted medical device includes two or more electrodes configured to electrically stimulate the splenic nerve, and may further include an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device.
Described herein are methods and devices for monitoring or modulating an immune system in a subject with cancer, and methods and devices for treating a cancer in a subject. The implanted device can electrically stimulate the splenic nerve of the subject, which can modulate the inflammatory system (for example, by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and/or anti-inflammatory cytokines to increase or decrease inflammation in the subject) and/or activate or increase circulation of one or more immune cells (such as natural killer cells and/or cytotoxic T-cells), for the treatment of cancer. The implanted medical device includes two or more electrodes configured to electrically stimulate the splenic nerve, and may further include an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device.
A helical nerve cuff and an implantable device comprising the helical nerve cuff and a body comprising a wireless communication system are described herein. The implantable device can include a body having a wireless communication system: electrodes that can detect an electrophysiological signal transmitted by a nerve or emit an electrical pulse to the nerve; and a helical nerve cuff. Also described are methods of implanting the helical nerve cuff and the implantable device, as well as methods of making the helical nerve cuff and the implantable device.
Method and system embodiments for operating a device implantable in a subject using ultrasonic waves are described. In some embodiments, a method is performed at the implantable device to receive ultrasonic waves including an operating mode command. Then, the implantable device sets an operating mode of the implantable device to one operating mode from a plurality of predetermined operating modes based on the operating mode command.
Method and system embodiments for operating a device implantable in a subject using ultrasonic waves are described. In some embodiments, a method is performed at the implantable device to receive ultrasonic waves including an operating mode command. Then, the implantable device sets an operating mode of the implantable device to one operating mode from a plurality of predetermined operating modes based on the operating mode command.
Method and system embodiments for controlling power provided to a device implantable in a subject are described. In some embodiments, a method is performed at the implantable device to receive, from an interrogator, powering ultrasonic waves having a wave power. Then, energy from the powering ultrasonic waves is converted into an electrical signal to power the implantable device. Information that indicates whether more power or less power should be transmitted to the implantable device is transmitted to the interrogator.
Method and system embodiments for controlling power provided to a device implantable in a subject are described. In some embodiments, a method is performed at the implantable device to receive, from an interrogator, powering ultrasonic waves having a wave power. Then, energy from the powering ultrasonic waves is converted into an electrical signal to power the implantable device. Information that indicates whether more power or less power should be transmitted to the implantable device is transmitted to the interrogator.
Described herein are implantable device networks that include two or implantable devices configured to modulate neural activity in a subject. The network includes at least one implantable device that can detect a detection signal, such as an electrophysiological signal or a physiological condition. The network also includes a second implantable device configured to emit an electrical pulse based at least on information related to the detection signal. The implantable devices in the network can wirelessly communicate between each other, either directly or through an intermediate device.
Described herein are implantable closed-loop neuromodulation devices, systems that includes such devices and an interrogator configured to emit ultrasonic waves that power the device, methods of using such devices and systems, and methods of modulating neural activity. The implantable device can include one or more curved members extending from a body. The curved members are configured to at least partially circumscribe a nerve, and include one or more electrode pads. The body includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy; and a computational circuit configured to receive a detection signal based on a detected electrophysiological signal, generate a stimulation signal based on the detection signal, and operate the electrode pads of to emit an electrical pulse to the nerve based on the stimulation signal.
Described herein are implantable closed-loop neuromodulation devices, systems that includes such devices and an interrogator configured to emit ultrasonic waves that power the device, methods of using such devices and systems, and methods of modulating neural activity. The implantable device can include one or more curved members extending from a body. The curved members are configured to at least partially circumscribe a nerve, and include one or more electrode pads. The body includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy; and a computational circuit configured to receive a detection signal based on a detected electrophysiological signal, generate a stimulation signal based on the detection signal, and operate the electrode pads of to emit an electrical pulse to the nerve based on the stimulation signal.
Described herein are methods for monitoring or modulating an immune system in a subject; treating, reducing or monitoring inflammation; monitoring blood pressure; treating hypertension; or administering or adjusting a therapy for inflammation or hypertension in a patient by electrically stimulating the splenic nerve or detecting splenic nerve activity using an implanted medical device. Also described herein are implantable medical devices for performing such methods. The implanted medical device includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device, two or more electrodes in electrical communication with the ultrasonic transducer that are configured to electrically stimulate a splenic nerve or detect a splenic nerve activity, and optionally a splenic nerve attachment member.
Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.
Described herein are methods for monitoring or modulating an immune system in a subject; treating, reducing or monitoring inflammation; monitoring blood pressure; treating hypertension; or administering or adjusting a therapy for inflammation or hypertension in a patient by electrically stimulating the splenic nerve or detecting splenic nerve activity using an implanted medical device. Also described herein are implantable medical devices for performing such methods. The implanted medical device includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device, two or more electrodes in electrical communication with the ultrasonic transducer that are configured to electrically stimulate a splenic nerve or detect a splenic nerve activity, and optionally a splenic nerve attachment member.
Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.
Described herein are methods for monitoring or modulating an immune system in a subject; treating, reducing or monitoring inflammation; monitoring blood pressure; treating hypertension; or administering or adjusting a therapy for inflammation or hypertension in a patient by electrically stimulating the splenic nerve or detecting splenic nerve activity using an implanted medical device. Also described herein are implantable medical devices for performing such methods. The implanted medical device includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device, two or more electrodes in electrical communication with the ultrasonic transducer that are configured to electrically stimulate a splenic nerve or detect a splenic nerve activity, and optionally a splenic nerve attachment member.
Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.
patents
