The present disclosure sets forth biocompatible composition for use as a bone hemostat. The composition comprises thrombin and an alkylene oxide copolymer ("AOC") blend. The thrombin may be sourced from human thrombin, bovine thrombin, or recombinant origin. The AOC blend consists of Poloxamer 188 and Pluriol V-10. The Poloxamer 188 constitutes 45% by weight of the total AOC blend, and the Pluriol V-10 constitutes 55% by weight of the total AOC blend.
A gasless spray tip assembly for mixing and dispensing multi-component compositions includes a body defining a cannula; an insert configured to fit within a portion of the cannula; and a cap configured to secure with the body. The cap includes a plurality of channels tangent to and in fluid communication with a hollow chamber and an outlet orifice in fluid communication with the hollow chamber. A width of each of the plurality of channels is between about 0.1 mm and 0.3 mm, and a diameter of the hollow chamber is between about 0.65 to about 0.85 mm.
A spray tip assembly for providing a viscous fluid includes a body comprising an outlet orifice; and an insert configured to fit within the body. The spray tip assembly comprises a plurality of channels tangent to and in fluid communication with a hollow chamber. Each of the plurality of channels has a length between about 0.4mm and about 1.0mm.
A system includes at least one infusion pump, an EMR server, an analysis engine, and a communication server. The analysis engine is configured to receive programming parameters and patient information from at least one of the infusion pump(s) and the EMR server. The analysis engine further configured to use at least one machine learning model configured to detect errors and abnormalities of programming parameters to generate an alert based, at least in part, on the programming parameters and the patient information. The communication server is communicatively coupled to a database and configured to both send and receive information from the infusion pump(s) and the analysis engine. The information received from the analysis engine includes the alert, which is saved in the database and transmitted to the infusion pump(s).
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
5.
DESIGN AND LOGIC TO DETECT INFUSION PUMP VERTICAL DISPLACEMENT AND MEASURE UNINTENDED BOLUS, MISSING VOLUME, TIME WITHOUT INFUSION, AND OTHER PARAMETERS
Improved medical pump designs, systems, and logic to detect medical pump vertical displacement are provided. The relative position of the pump with respect to an initial position set by a user may be measured. The designs, systems, and logic may also be used to detect the change in the height of a patient relative to the medical pump during therapy by measuring hydrostatic pressure in a patient line. The detected change in vertical displacements can be used to determine the volume of an unintended bolus or a missing volume during infusion therapy. The therapy may be adjusted based on the unintended bolus or missing volume as desired. The designs, systems, and logic may further include a transport mode to help maintain consistent therapy while a patient is ambulated or the pump is moved.
The present disclosure relates to improved lipid emulsions for providing parenteral nutrition, including ready-to-use parenteral nutrition formulations comprising such lipid emulsions. More particularly, the present disclosure is directed to improved lipid formulations or emulsions including multi-chamber containers comprising same, wherein the lipid emulsion contains DHA, EPA, and ARA in an optimized concentration and ratio, optionally in combination with choline and defined levels of phytosterols. The present disclosure further relates to methods of avoiding and/or treating liver damage and/or inflammation, and to methods for improving fatty acid profiles in plasma and certain tissues or organs especially of pediatric patients.
A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
A23L 33/115 - Fatty acids or derivatives thereofFats or oils
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/14 - Quaternary ammonium compounds, e.g. edrophonium, choline
A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
7.
MANUFACTURABILITY IMPROVEMENTS FOR LAPAROSCOPIC INTRODUCER
An introducer assembly for applying a film at a surgical site includes a winding rod with a shaft that extends from a handle. The handle is located at a proximal end of the winding rod and includes a plurality of raised protrusions. The shaft includes a slit located at its distal end. The shaft of the winding rod has a dumbbell-shaped cross-section. The introducer assembly also includes an outer cannula assembly with a metallic tube coupled to a molded grip located at the proximal end of the metallic tube. The metallic tube includes a slit at its distal end and a notch at its proximal end; the notch is configured to mate with a tab on the molded grip for rotational clocking. The molded grip includes at least one substantially flat surface to prevent rolling, and includes a plurality of ribs radiating from the surface of the molded grip.
A61B 17/00 - Surgical instruments, devices or methods
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A non-ratcheting surgical clip application device for applying and crimping surgical clips to ligate a vessel. The surgical clip applying device includes an enclosure formed from a top housing, a bottom housing and a window cover, a pair of handles including a left handle and a right handle each mounted for pivotal movement in the bottom housing, a main rail fixedly mounted to the bottom housing within the enclosure, a pair of clip applying jaws fixedly attached to the bottom housing and mounted through the main rail, a jaw closer comprising a proximal end, a distal end, and an elongate base, and a drive mechanism including a plurality of levers and at least one spring.
A61B 17/128 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips
9.
IMPROVED WORK STATIONS FOR PREPARATION OF MEDICAL DOSES
Improved medical dose preparation work stations and accessories are described. The medical dose preparation work station includes a camera for capturing medical dose preparation images (e.g., to document preparation of a mediation dose). The camera may be actuated by an operator using a plurality of membrane buttons on a base of the medical dose preparation work station. The medical dose preparation work station further includes an adjustable arm to hold the camera at a desired focal length from a staging area defined by a tray such that objects in the images from the camera remain in focus. The tray includes a light side and a dark side configured to provide a high contrast background for an operator and for the camera.
A61G 12/00 - Accommodation for nursing, e.g. in hospitals, not covered by groups , e.g. trolleys for transport of medicaments or foodPrescription lists
A61J 3/00 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
A61J 7/00 - Devices for administering medicines orally, e.g. spoonsPill counting devicesArrangements for time indication or reminder for taking medicine
G01G 23/37 - Indicating the weight by electrical means, e.g. using photoelectric cells involving digital counting
G01N 21/88 - Investigating the presence of flaws, defects or contamination
G06Q 10/0639 - Performance analysis of employeesPerformance analysis of enterprise or organisation operations
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
A system and apparatus for securing a pump are disclosed. The system includes a patient-controlled analgesia ("PCA") pump, a security door, a security frame assembly, and a diversion guard. The PCA pump can be placed in the security frame assembly. The security door interlocks with the security frame assembly and pivots about it from an open configuration to a closed configuration. When the security door is in a closed configuration, the medicament-administering components of the PCA pump are out of reach from unauthorized users. As an additional physical barrier, the diversion guard selectively couples to the security frame assembly, such that it blocks a physical gap between the security door and security frame assembly when the security door is in a closed configuration.
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
11.
USER INTERFACE FOR PCA PUMP PROGRAMMING TO PREVENT DOSE ERRORS
Methods, systems, and apparatus are disclosed herein for a PCA pump user interface that provides on-screen parameter programming guidance to prevent dosage errors. The example methods, systems, and apparatus are configured to display parameter range line graphs on a PCA pump user interface screen in accordance with the lower and upper limits established for a user-inputted parameter. Additionally, the example methods, systems, and apparatus are configured to generate and display user alerts and does not allow users to enter the parameter if it is not in acceptable range when a user inputted parameter value affects the range of values acceptable by a previously entered parameter value.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
An aseptically prepared pharmaceutically acceptable azithromycin premix formulation has a pH value of 5.5 to 7.5, preferably 6.0 to 7.0, more preferably 6.3 to 7.0, even more preferably 6.3 to 6.7, for example about 6.5. Preferred embodiments of the aseptically prepared pharmaceutically acceptable azithromycin premix formulation contain azithromycin, a buffering agent, water and optionally a tonicity adjusting agent and are stable for one month, three months, six months, nine months, twelve months, fifteen months, eighteen months or even twenty-four months, during storage at refrigerated temperatures, such as about 5 °C, even without any additional components beyond the azithromycin, the buffering agent, and the optional tonicity adjusting agent in the premix formulation. The pharmaceutically acceptable azithromycin premix formulation may be aseptically filled into a container, preferably a glass or flexible container, to form a sterile pharmaceutical azithromycin premix product which does not undergo terminal sterilization. The azithromycin premix product can be a single use premix which is a sterile, stable and ready-to-use aqueous solution for parenteral administration, for example intravenous (IV) administration such as IV infusion, and requires no dilution prior to parenteral administration.
A medical fluid control port assembly is disclosed. The medical fluid control port assembly eliminates contamination of a fluid path in peritoneal dialysis solution containers by incorporating ways to operate fluid flow without using a frangible. The disclosed fluid control port assembly is made up of an upper stem and a lower stem. The upper stem has a male threaded portion configured for mating to the lower stem having a female threaded portion. The upper stem has at least two snapfit ridges and the lower stem has at least one snapfit ridge. The snapfit ridges are provided to lock the fluid control port in a closed configuration to restrict fluid flow, or in an open configuration to initiate fluid flow. The control port is configured to allow a patient to use their fingers to rotate the upper stem and lower stem during dialysis therapy to easily control fluid flow.
A water purification apparatus capable of being cleaned at a point of care and methods for cleaning the water purification apparatus at the point of care are disclosed herein. The water purification apparatus and the methods provide an efficient use of a heater for heat disinfection the water purification apparatus. The water purification apparatus and the methods provide heat disinfection by recirculating heated fluid to further heat the fluid. Several different cleaning programs are provided that may be utilized for cleaning different parts of the water purification apparatus.
New and improved container outlet valve closures are provided for medical solution containers. The closures are flexible and keep the solutions in their containers until acted upon. By applying a certain force on the closure, a pop-up valve is opened to permit flow of the medical solution from the container. The closures may be used with a variety of materials. Closure opening is easily activated and does create particle pollution for the medical solution. Closures for sidewall mounted and gondola style containers are provided.
A bag in a box therapy system may be provided by an item of manufacture, comprising: a box, containing: a first bag; a second bag; and a plurality of tubes and a tube connector; wherein the first bag comprises an internal reservoir and a first port, and contains a fluid disposed within the internal reservoir; and the plurality of tubes is configured provide one-way fluid communication from the internal reservoir to the tube connector via the first port, and configured provide one way fluid communication from the tube connector to the second bag.
A peelable tube, as may be used as part of a port, may be provided by a tube having a first end and a second end, opposite to the first end, between which a fluid passage is defined when in an open configuration, wherein a welded seal is defined between the first end and the second end to place the tube in a closed configuration that blocks fluid communication between the first end and the second end, wherein the welded seal is configured to disengage and return the tube to the open configuration when a compressive force is applied to the welded seal in a direction perpendicular to a longitudinal axis of the tube.
A medical fluid delivery system may be provided, comprising a supply reservoir, a supply tube, an exchange port, and a drain reservoir secured to the exchange port with a locking ring, wherein a wall of the drain reservoir is configured to expand in surface area responsive to an outward fluid pressure upon an interior surface of the drain reservoir to allow the drain reservoir to distend to accommodate fluid from the exchange port.
A solution warming container may be provided by a fluid heating system, including a fluid container, including an internal reservoir configured to contain a fluid, an external surface, defined around the internal reservoir and defining a recess, a first and second electrode disposed within the reservoir, a first and second electrical contact electrically connected to the first and second electrode; and a charging device having a third and fourth electrical contact, the charging device is matched with the recess, such that in an engaged configuration the charging device is disposed within the recess, and the first electrical contact is aligned with the third electrical contact, and the second electrical contact is aligned with the fourth electrical contact, and electrical power is delivered from the charging device to the first electrode, and through the fluid to the second electrode.
H05B 3/60 - Heating arrangements wherein the heating current flows through granular, powdered or fluid material, e.g. for salt-bath furnace, electrolytic heating
A61M 5/44 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for cooling or heating the devices or media
20.
DIALYSIS SYSTEM HAVING PATIENT LINE OCCLUSION DETECTION AND INTRAPERITONEAL PRESSURE ESTIMATION
A peritoneal dialysis ("PD") system includes a PD fluid pump configured to pump PD fluid along a line under negative pressure and to create a negative pressure profile having a maximum negative pressure and a minimum negative pressure; a pressure sensor positioned and arranged to sense the negative pressure profile and to produce an output indicative of the negative pressure profile including a maximum negative pressure output and a minimum negative pressure output; and a control unit configured to analyze the output indicative of the negative pressure profile and to determine that an occlusion in the line has occurred if both the maximum negative pressure output and the minimum negative pressure output change by at or more than a set pressure delta, wherein the set pressure delta is optionally the same pressure delta for the maximum negative pressure output and the minimum negative pressure output.
Provided herein is a peritoneal dialysis ("PD") system comprising a housing and one or more doors comprising elastomeric properties. Each of the one or more doors comprises one or more features configured to couple to one or more features of the housing. Further, each door includes one or more inserts molded between two layers of elastomeric material where the features are coupled to. The doors are configured to cover and thermally insulate one or more PD fluid lines when in a closed configuration. The doors are also configured to transition to an open configuration to provide access to one or more PD fluid lines for treatment.
The present invention relates to a novel solid pharmaceutical preparation for peritoneal dialysis comprising nucleating particles of sodium chloride coated with plurality of layers, wherein the plurality of layers comprises, a first layer (A) of sodium bicarbonate, second layer (B) comprising sodium chloride and dextrose, third layer (C) comprising the electrolytes calcium chloride and magnesium chloride, and the fourth outmost layer (D) comprising sodium lactate. The present invention also relates to a process for producing the novel solid pharmaceutical preparation.
A peritoneal dialysis ("PD") system having an ultrafilter is disclosed herein. In one example, the PD system includes a housing and a PD fluid pump. The PD system also includes a filter comprising an outer chamber, a central portion, a membrane, an inlet connected to the outer chamber, an outlet, a first venting port connected to the outer chamber, and a second venting port connected to the central portion. The first venting port has a valve preventing air flow into the filter via the first venting port. The PD system further includes a pressure sensor and a control unit configured to control the PD fluid pump. The control unit is further configured to determine a pressure inside the filter based on an output from the pressure sensor and determine an integrity status of the membrane based on the pressure inside the filter.
A system, method, and apparatus are disclosed for determining positions of medical devices within a hub, which comprises a number of apparatuses that are linked together in a stacked configuration. A medical device hub includes a connectivity apparatus that is communicatively coupled to a medical network and/or a monitoring device. Additionally, the medical device hub includes one or more docking apparatuses. Each docking apparatus can accommodate two or more infusion pumps. The number of docking apparatuses used in the medical device hub depends on the number of infusion pumps needed for a patient treatment. The medical device hub enables multiple docking apparatuses to be stacked as needed while enabling the infusion pumps to be operated independently and removed from the medical device hub as needed, even during a treatment without interruption. Such a configuration provides a scalable, flexible, and adaptable system that aggregates infusion pumps into a relatively small footprint.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
25.
MEDICAL DEVICE HUB CONNECTION SYSTEM, METHOD, AND APPARATUS
A medical device hub power management system, method, and apparatus are disclosed. An example infusion pump docking apparatus of a hub connectivity station includes a housing and a device connector assembly. The device connector assembly includes a mounting bracket fixedly connected to an interior surface of the housing forming a mounting cavity between the mounting bracket and the housing. The device connector assembly also includes a device connector to provide electrical connection between the docking apparatus and a medical device, where the device connector is positioned in the mounting cavity. The device connector assembly also includes a spring positioned in the mounting cavity between a flange surface of the mounting bracket and a rear surface of the device connector. The spring is deformable during connection of the medical device to the device connector to allow movement of the device connector within the mounting cavity.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
An infusion pump for detecting an occlusion is provided. The memory stores instructions that cause the one or more processors to input data into a trained neural network, and generate an alert when the trained neural network outputs an amount of occlusion flags above a predetermined threshold.
A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
27.
DIALYSIS SYSTEM HAVING PUMP ACTUATOR POSITION DETECTION
A peritoneal dialysis ("PD") system includes a PD fluid pump including a reciprocating member having a home position; at least one pressure sensor positioned and arranged to sense pressure PD fluid pumped by the PD fluid pump; and a control unit configured to control the PD fluid pump and to take PD fluid pressure readings from the at least one pressure sensor, the control unit further configured to use the PD fluid pressure readings to determine when the reciprocating member is in the home position, and to stop the PD fluid pump when the reciprocating member is in the home position.
An apparatus for breaking a frangible engaged with a medical catheter is provided. The medical catheter includes a first catheter section and a second catheter section which are connected with each other via a connector having a first flange, where the frangible is engaged with the second catheter section. The apparatus includes a first component having a first end and a second end opposite to the first end. The first component includes: a first groove formed on top of the first component and extending along a longitudinal direction of the first component from the first end of the first component to the second end of the first component, where the first groove is configured for receiving the first catheter section and a part of the second catheter section; a first slot formed perpendicular to and recessed from the first groove, wherein the first slot is positioned close to the first end of the first component and configured for receiving the first flange; and a first catheter clamping bulge protruding from a surface of the first groove, where the first catheter clamping bulge is positioned closer to the first end of the first component than the first slot.
An apparatus for breaking a frangible is provided. The frangible is engaged with a medical catheter. The apparatus includes: an elongated handle and a clamping portion; the elongated handle is configured for being gripped by a hand of an operator; the clamping portion is arranged at a distal end of the elongated handle and includes two clamping arms protruding away from the elongated handle in a longitudinal direction of the elongated handle; the two clamping arms are spaced apart from and parallel to each other to form a trench for partially receiving a portion of the medical catheter where a frangible end of the frangible is located; and the two clamping arms are configured for applying a breaking force on the frangible end of the frangible when the elongated handle is rotated around a longitudinal axis of the elongated handle by the operator.
Example systems, methods, and apparatus are disclosed herein for dynamically assigning unique message identifiers for devices in a CAN bus network. The example systems, methods, and apparatus are configured to allow devices, such as infusion pumps, to propose and acquire unique IDs within a CAN bus network. The example systems, methods, and apparatus are configured to use the exchange of information between devices in a CAN bus network to prevent duplicate unique IDs, and to allow for simultaneous unique IDs to be acquired by devices. The disclosed systems, methods, and apparatus prevent human programming errors by minimizing the need for extensive user interaction with devices joining a CAN bus network and need to know and select node IDs during installation. The disclosed systems, methods, and apparatus increase network efficiency and prevent programming errors that might result in patient discomfort or injury in healthcare settings, such as networks including infusion pumps.
Retainer apparatus may be configured to retain a cable having a connector operably coupled to a device The retainer apparatus may include a mounting portion configured to be selectively coupled to the device and an insertion portion coupled to the mounting portion. The insertion portion may define a channel configured to receive the connector of the cable and to restrict the connector of the cable from moving away from the device when the connector is operably coupled to the device and received in the channel and the mounting portion is coupled to the device.
A drug infusion system comprises a plurality of infusion pumps including a first infusion pump and a second infusion pump and a computing device. The computing device comprises a non-transitory computer-readable storage medium and a processor coupled to the non-transitory computer-readable storage medium. The processor is configured to control a plurality of modules to establish a relay sequence of the plurality of infusion pumps to sequentially deliver drugs associated with each of the plurality of infusion pumps to a patient, in response to detecting that the first infusion pump completes an infusion, automatically transfer infusion status information of the first infusion pump to the second infusion pump in the relay sequence, activate the second infusion pump to start infusing in accordance with the relay sequence, remove the first infusion pump from the relay sequence, and retain operational parameters of the first infusion pump.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
This application provides a male connector for a peritoneal tubing carried by a patient practicing ambulatory peritoneal dialysis, a cap, and a female connector. The male connector includes: a hollow main body having a first end and a second end, where the hollow main body is configured to be sealingly connected with the peritoneal tubing at the first end, where the hollow main body includes an engaging portion, a base, and a flip snap. The engaging portion is at the second end of the hollow main body, and the engaging portion includes a conic outer surface having a diameter reducing toward the second end; the base is positioned between the first end and the engaging portion; and the flip snap is pivotably connected to the base, where the flip snap is configured to pivot relative to the base between an idle position where the flip snap engages with the base, and a locking position where the flip snap can releasably engage with a cap or a female connector.
A medical device hub power management system and apparatus are disclosed. An example hub connectivity station (100) includes a connectivity stage (104) configured to provide a data connection with an external network. The hub connectivity station also includes at least one docking apparatus (106) configured to connect to at least one medical device. The docking apparatuses are connected to the connectivity station in a stacked arrangement. The docking apparatuses and connectivity stage include power and data connectors to enable data and power to be provided through the hub connectivity station. To prevent electrical shock, a top power connector of each docking apparatus is disconnected from power when that docking apparatus is not connected to another docking apparatus or the connectivity stage. Power is provided to the top power connector after detecting another docking apparatus or the connectivity stage is connected to the top of the docking apparatus.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
35.
SYMMETRIC KEY EXCHANGE VIA TLS (TRANSPORT LAYER SECURITY) ON CAN (CONTROLLER AREA NETWORK) BUS INTERFACE
Symmetric key exchange via TLS on CAN bus interface for multiple devices. The key exchange is configured to elect a master PCA pump for a CAN bus network and prevent two PCA pumps from being master. Upon joining the CAN bus network PCA pumps exchange their MAC IDs with the PCA pumps in the CAN bus network. Once a bootstrap timeout ends, each PCA pump compares all MAC IDs to determine if it should advance to the voting stage. If the PCA pump has the lowest MAC ID, the PCA pump enters the voting stage. During the voting stage, the PCA pump sends master requests prompts to all the PCA pumps in the network. If the PCA pump's internal vote counter reaches a count of three the PCA pump becomes key master.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
36.
MEDICAL DEVICE SPEECH AND GESTURE CONTROL METHODS, APPARATUSES, AND SYSTEM
Methods, apparatuses, and systems for medical device speech and gesture control are disclosed herein. An example apparatus includes an audio interface that converts received audio into text, for example. The audio interface uses a current operating statue of the medical device to determine a command from the text and whether the command is enabled. When the command is enabled, the audio interface transmits a command message to a response manager, which converts the command to a medical device command signal. The response manager then transmits the medical device command signal to a control engine of the medical device to change how the medical device is operating based on the received audio. The same medical device command signal is used for similar touch and/or gesture inputs such that the control engine does not need to be modified based on which input modalities are implemented on the medical device.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
The present disclosure relates to improved lipid emulsions for providing parenteral nutrition, including ready-to-use parenteral nutrition formulations comprising such lipid emulsions. More particularly, the present disclosure is directed to improved lipid formulations or emulsions including multi-chamber containers comprising same, wherein the lipid emulsion contains DHA, EPA, and ARA in an optimized concentration and ratio, optionally in combination with choline and defined levels of phytosterols. The present disclosure further relates to methods of avoiding and/or treating liver damage and/or inflammation, and to methods for improving fatty acid profiles in plasma and certain tissues or organs especially of pediatric patients.
A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
A23L 33/11 - Plant sterols or derivatives thereof, e.g. phytosterols
A23L 33/115 - Fatty acids or derivatives thereofFats or oils
A23D 7/00 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines
A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
A23D 7/01 - Other fatty acid esters, e.g. phosphatides
39.
DRAINAGE PLATE, TRAY AND SYSTEM FOR MOIST HEAT STERILIZATION
A drainage plate, a tray and a system for moist heat sterilization are provided. The drainage plate has a plurality of apertures sized to allow the fluid to pass through and includes a first region having a first aperture ratio; a second region having a second aperture ratio; and a third region having a third aperture ratio. The first region, the second region and the third region are sequentially arranged in a widthwise direction of the drainage plate, and the second aperture ratio is greater than the first aperture ratio and the third aperture ratio.
A system is provided for characterizing an effluent sample from a patient undergoing peritoneal dialysis. The system features a container (30) for enclosing the effluent sample, an optical system, an electrical system, and a processor (13). The optical system features a light source (18, 24) and a photodetector (14, 54), the light source emitting a beam of radiation that passes through the container and irradiates the effluent sample, and the photodetector detecting the radiation after it irradiates the effluent sample to generate an optical signal. The electrical system features at least one pair of electrodes (38a, 38b) attached to the container and arranged to measure an electrical property of the effluent sample to generate a property signal. The processor operates an algorithm that collectively processes the optical and property signals to characterize the effluent sample.
A device and method for parenteral administration of a solution of a therapeutic agent include a fluid reservoir having a chamber for holding fluid and an outlet port. The outlet port is fluidly coupled to a therapeutic agent conduit having a fluid inlet and a fluid outlet that define a fluid flow path. An infusion device is fluidly connected to the fluid outlet of the therapeutic agent conduit. The infusion device is capable of parenteral administration of fluid. A polymeric matrix is disposed in the therapeutic agent conduit, the polymeric matrix having a therapeutic agent dispersed therein. The therapeutic agent is at least partially dissolvable when contacted by fluid and a solution of the therapeutic agent is formed when contacted by the fluid.
A medical fluid container tubing assembly includes a medical fluid container, a luer connector including a luer port, a tube extending from the medical fluid container and terminating at the luer connector, and a cap fitted onto the luer connector. The cap includes a port sized to provide an interference fit with the luer port of the luer connector. The cap further includes a hydrophobic filter positioned and arranged to allow air to aseptically enter the tube to equalize pressure inside and outside of the tube. The cap may include an inner port including an inner surface tapered for forming an interference fit with an outer surface of a male luer port of a luer connector, an outer shroud sized to fit around an outer shroud of the luer connector, a lumen extending from the port to an opening, and a hydrophobic filter covering an opening formed by the lumen.
Example systems, methods, and apparatus are disclosed herein for the automatic programming of a near empty alarm activation threshold based on an infusion therapy type selected by the user on a syringe pump. The example systems, methods, and apparatus are configured to use a preloaded drug library to determine if the selected infusion therapy type includes a PCA bolus or not, and define an appropriate time- or volume-based alarm activation threshold accordingly. The disclosed systems, methods, and apparatus prevent human programming errors by minimizing the need for extensive user interaction with syringe pumps. Further, the disclosed systems, methods, and apparatus allows for automatic programming to increase efficient infusion administration, and prevent programming errors that might result in patient discomfort or even injury.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
45.
POWER ADAPTER WITH UNITED KINGDOM AND AUSTRALIA INTERCHANGEABLE BLADE WITH BUILT-IN FUSE IP-34 PROTECTION
Example systems, methods, and apparatus are disclosed herein for an interchangeable IPx4 UK blade with built-in fuse with a built-in fuse. The example systems, methods, and apparatus are configured to allow the user to replace used fuses from the interchangeable IPx4 UK blade with built-in fuse while providing water-sealing protection. Additionally, the example systems, methods, and apparatus are disclosed herein for an interchangeable IPx4 AU Blade. The disclosed systems, methods, and apparatus allow the user to use the interchangeable IPx4 AU Blade with all power adapters while providing water-sealing protection. Further, the disclosed systems, methods, and apparatus lower power adapter use cost by allowing the user to easily replace fuses without having to replace the entire power adapter. Finally, the disclosed systems, methods, and apparatus increase efficient power adapter use by orienting the power adapter such that electrical cords to not block unused power sockets.
H01R 13/688 - Structural association with built-in electrical component with built-in fuse the fuse being removable with housing part adapted for accessing the fuse
H01R 31/06 - Intermediate parts for linking two coupling parts, e.g. adapter
H01R 13/52 - Dustproof, splashproof, drip-proof, waterproof, or flameproof cases
A medical fluid container tubing assembly includes a medical fluid container, a first luer connector, a tube extending from the medical fluid container and terminating at the first luer connector, and a cap fitted onto the first luer connector. The cap includes a hydrophobic filter positioned and arranged to allow air to aseptically enter the tube to equalize pressure inside and outside of the tube. The medical fluid container tubing assembly also includes a supply line extending from a medical fluid destination and terminating with a second luer connector. The second luer connector is configured to mate with the first luer connector when the cap is removed from the first luer connector.
Example systems, methods, and apparatus are disclosed herein for on-screen parameter programming guidance based on user-inputted data and patient history graphical display generation based on a user-inputted command. The example systems, methods, and apparatus are configured to use a preloaded drug library to determine the upper and lower limits of parameters, and display a color graph and differently-colored text on a PCA pump user interface screen accordingly. Additionally, the example systems, methods, and apparatus are configured to use real-time patient history data to generate and display a patient history graph on a user interface screen. The disclosed systems, methods, and apparatus prevent human programming errors by minimizing the need for extensive user interaction with PCA pumps and the need to toggle between programming screens. Further, the disclosed systems, methods, and apparatus prevent human programming errors by displaying patient history in a single, consolidated graph.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
48.
METHODS, APPARATUS, AND SYSTEM FOR PAIRING A PATIENT'S MOBILE DEVICE WITH A MEDICAL DEVICE
Methods, apparatus, and systems for pairing a patient's mobile device with a medical device are disclosed. The methods, systems, and apparatus use a server that is securely connected to a medical device to manage a pairing process. The secure connection between the server and the medical device is used to transmit a certificate in addition to a phone number of a patient's mobile device. The server also transmits a pairing code to the medical device using the secure connection. The medical device displays the pairing code. A patient causes the mobile device to record the code, which is transmitted to the server to perform a congruency check by comparing the received code to the generated code. When the codes match, the server transmits a device identifier of the mobile device to the medical device, which enables the medical device to establish a secure proximity communication channel with the medical device.
G16H 10/00 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data
G16H 40/00 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
49.
DIALYSIS SYSTEM HAVING MOTOR DRIVER PRESSURE ESTIMATION OF FLUID WITHIN A PATIENT LINE
A dialysis system having motor driven pressure estimation of fluid within a patient line is disclosed. A peritoneal dialysis ("PD") system includes a fluid pump and a patient line that fluidly couples the fluid pump to an indwelling catheter leading into a patient's peritoneal cavity. The PD system also includes a motor driver that controls a motor of the fluid pump and transmits an output signal that is indicative of a load on the motor. The PD system further includes a machine learning algorithm that associates data related to output signals from motor drivers with known fluid pressures within patient lines. A processor of the PD system transmits an input signal to activate the motor driver, receives the output signal from the motor driver, and estimates a fluid pressure within the patient line by applying the data from the received output signal to the machine learning algorithm.
A peritoneal dialysis ("PD") disinfection device includes a top made of a material configured to let light pass through the material, a bottom, a printed circuit board ("PCB") secured between the top and the bottom, a plurality of ultraviolet light emitting diodes ("UV-LEDs") secured to the PCB, and a power source operable to supply power to the plurality of UV-LEDs. At least one of the top, the bottom, and the PCB includes a feature that enables a patient to locate and orient the PD disinfection device so that UV light from the plurality of UV-LEDs is directed towards a connection end of the patient's catheter or a catheter/patient exit site.
A peritoneal dialysis ("PD") system includes a PD machine and a docking station connected to the PD machine via a power cord. The docking station includes a plurality of connectors configured to receive a cable of one or more wired peripheral entity, a transceiver for wireless communication with one or more wireless peripheral entity, and a power supply rated to power the PD machine during a PD treatment that includes batch or inline PD fluid heating.
Systems and methods are disclosed for assessing the functionality of solenoid valve activation in peritoneal dialysis systems. In at least one embodiment, measurements of current values may be received from a solenoid valve at a predetermined sampling rate over a predetermine duration of time to generate a current profile for the solenoid valve. A fifth degree polynomial model may be fit to the current profile and optimized. The optimized polynomial model may be applied to a trained support vector machine to determine whether the current profile indicates that the corresponding solenoid valve has actually opened or closed.
F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
F16K 31/06 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic using a magnet
H01F 7/18 - Circuit arrangements for obtaining desired operating characteristics, e.g. for slow operation, for sequential energisation of windings, for high-speed energisation of windings
53.
DIALYSIS SYSTEM HAVING REDUCED VALVE NOISE AND VALVE POSITION DETECTION
Systems and methods are disclosed for reducing valve noise and detecting a valve position in medical fluid systems. One method includes transmitting, by a microcontroller, a control signal for closing a valve via pulse width modulation (PWM) signals. The valve is configured to control a fluid flow in the medical fluid system. The valve may be open at least before the control signal is transmitted. The valve comprises a housing, a solenoid coil, and a plunger. The method further includes applying power to the valve to measure voltage across the valve and monitoring, based on a sense resistor, the voltage across the valve over a measurement interval. The measurement interval terminates when the voltage reaches a predetermined threshold voltage. The method also includes comparing the measurement interval to a reference interval for a normally functioning closed valve and generating, based on the comparison, an assessment of the valve position.
Systems and methods are disclosed for reducing noise in solenoid valve activation and deactivation in peritoneal dialysis ("PD") systems. In at least one embodiment, the PD system operates with solenoid valves under the control of a control unit. The control unit takes measures to control the movement of the solenoid valve to minimize the amount of sound that occurs at impact during activation and deactivation of the valve. The measures include the slowing of the movement of the valve plunger within the valve coil. In one aspect, the valve plunger may be slowed down by applying voltage to the valve coil through pulse width modulation ("PWM").
A dry concentrate bag for preparing a dialysis fluid comprising one or more plastic films defining two welded together to define a housing space for the dry concentrate; a dry concentrate housed within the housing space; an inlet portion placed in correspondence of a bottom area in use conditions of the dry concentrate bag and comprising an inlet port for receiving a fluid; an outlet portion placed in correspondence of a top area in use conditions of the dry concentrate bag and comprising an outlet port for letting the fluid mixed with the dry concentrate to leave the housing space. The inlet portion comprises a first and a second inclined welding lines both emerging from the inlet port and defining a lower cone portion of the housing space, the inlet port being placed at the lowest point of the lower cone portion, wherein the outlet portion comprises a third and a fourth inclined welding lines both converging to the outlet port and defining an upper cone portion of the housing space, the outlet port being placed at the highest point of the upper cone portion.
A medical fluid generation apparatus is provided with a fluid circuit including a main fluid line having an inlet for receiving water, a pump active on the main fluid line to circulate fluid, a plurality of valves on the fluid circuit configurable to define different fluid paths for the fluid inside the fluid circuit, a supporting structure having a first primary container access for fluid communication with a primary concentrate container and a first auxiliary container access for fluid communication with an auxiliary concentrate container, a mixing container having an inlet and an outlet. The fluid circuit comprises a medical fluid outlet placed downstream the pump; a mixing container outlet line connecting the outlet of the mixing container to a first junction point on the main fluid line placed upstream the pump; a mixing container inlet line connecting a sixth junction point on the main fluid line downstream the pump to the inlet of the mixing container; a primary concentrate container outlet line connecting the first primary container access to a fifth junction point on the main fluid line upstream the; an auxiliary concentrate container outlet line connecting the first auxiliary container access to a third junction point on the main fluid line upstream the pump.
A medical fluid generation apparatus comprises a fluid circuit including a main fluid line; a pump on the main fluid line; a plurality of valves to define different fluid paths for the fluid inside the fluid circuit; a mixing container having an inlet and an outlet both in fluid communication with the main fluid line; a sensor connected to the main fluid line to measure a property of the fluid flowing in the main fluid line; the fluid paths comprise a mixing recirculation path including the outlet, a portion of the main fluid line on which the pump operates, and the inlet A control unit controls the plurality of valves to set the mixing recirculation path and to allow a recirculation of the fluid contained in the mixing container through the mixing recirculation path. The control unit is further configured to recirculate the fluid in the mixing recirculation path; detect a time-resolved variation of the property of the fluid recirculating in the mixing recirculating path (the time-resolved variation of said property of the fluid is related to homogeneity of the fluid recirculating in the mixing recirculating path); interrupt the recirculation step upon the time-resolved variation meeting a variation criterion.
Extracorporeal blood treatment apparatus, methods, and systems to perform an extracorporeal blood treatment using an organic filter operable to perform the functions of an organ are described herein. The extracorporeal blood treatment apparatus includes a treatment set, a high flow pump, a first low flow pump, and a second low flow pump, and a computing apparatus operatively coupled to the extracorporeal blood treatment apparatus. The computing apparatus may be configured to perform an extracorporeal blood treatment using the extracorporeal blood treatment apparatus and the organic filter.
A wearable peritoneal dialysis system includes a PD fluid supply assembly including an outer container, and an inner PD fluid supply container sealed within the outer container; a pumping unit including an air pump having a positive pressure outlet and a negative pressure outlet; a PD fluid drain assembly including an outer leg container configured to be worn around a patient's leg, an inner PD fluid drain container sealed within the outer leg container; and a control unit configured to cause (i) positive pneumatic pressure to be supplied from the positive pressure outlet to the outer container to force fresh PD fluid to flow from the inner PD fluid supply container to the patient and (ii) negative pneumatic pressure to be supplied from the negative pressure outlet to the inner container to force used PD fluid to flow from the patient towards the inner PD fluid drain container.
In one example, a control unit causes (i) a second pneumatic valve and a source fluid valve to open and a linear actuator to move a piston head into a first cylinder chamber so as to create a negative pressure in a pneumatic pump chamber, pulling source fluid into a fluid pump chamber and (ii) a first pneumatic valve and a destination fluid valve to open and the linear actuator to move the piston head into the first cylinder chamber, pushing the source fluid through the destination fluid valve, the control unit using a pressure sensor reading to control the linear actuator so that a final pressure for (ii) at least substantially equals an initial pressure for (ii), such that a volume of space corresponding to the movement of piston head within the cylinder during (ii) equals a volume of the source fluid delivered from fluid pump chamber.
A peritoneal dialysis ("PD") system includes a housing, a PD fluid pump housed by the housing, and a reusable line in fluid communication with the PD fluid pump. The reusable line is configured to be pulled into the housing. The PD system also includes an external tubing surface cleaning unit positioned and arranged to at least one of (i) remove debris from at least a portion of the exterior of the reusable line as it is pulled into the housing, or (ii) apply disinfectant to at least the portion of the exterior of the reusable line as it is pulled into the housing.
A peritoneal dialysis ("PD") system includes a housing, a PD fluid pump housed by the housing, an inline heater in fluid communication with the PD fluid pump, a temperature sensor, and a control unit. The PD fluid pump and the inline heater are under control of the control unit, which receives a temperature signal from the temperature sensor. The control unit, in one embodiment, is configured to perform a heat disinfection sequence in which the control unit causes the PD fluid pump to pump disinfection fluid in a forward direction, while the inline heater heats the disinfection fluid, and in a reverse direction after the temperature signal indicates that a temperature of the disinfection fluid has fallen to or has fallen below a minimum disinfection temperature.
A method and system for delivering partial boluses using infusion pumps is disclosed. An example method includes storing a programmed dose volume to be administered in response to a request from a patient and instructing the pump to begin dispensing the programmed dose volume of fluid from the fluid supply. The method further includes receiving an indication that the pump has stopped pumping, determining a partial dose volume, and when the partial dose volume equals a value greater than zero, generate an alarm that the fluid supply is depleted. Additionally, the method includes exchanging the depleted fluid supply with a subsequent fluid supply, dispensing from the subsequent fluid supply the partial dose volume, and preventing any subsequent dispensing of fluid from the subsequent fluid supply for a programed lockout period.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A peritoneal dialysis ("PD") system includes a PD fluid pump; a patient line for receiving used PD fluid pumped by the PD fluid pump during a patient drain; a control unit configured to cause the PD fluid pump to pump, according to a first commanded pressure, the used PD fluid through the patient line during the patient drain; and a personal digital assistant ("PDA") in wireless communication with the control unit, the PDA configured to enable a patient while undergoing the patient drain to send a command to the control unit, the command instructing the control unit to cause the PD fluid to pump according to a second commanded pressure during the patient drain.
A peritoneal dialysis ("PD") transfer set includes a base having at least one slot; a slider extending within the base and including an elongated tube configured to carry PD fluid, the elongated tube extending to a head of the slider, the head including at least one lug extending through the at least one slot and further including a connector for connecting to a mating patient line connector; and a shroud barrel including at least one helical groove and extending around a portion of the base so that the at least one helical groove receives the at least one lug, wherein a user may rotate the shroud barrel including the at least one helical groove such that the at least one lug extends along the at least one helical groove, the at least one slot constraining movement of the at least one lug and the slider to being a translational movement.
A method of performing peritoneal dialysis (PD), the method comprising: delivering a PD fluid to the peritoneal cavity of a patient through a PD catheter; dwelling the PD fluid within the peritoneal cavity; and while dwelling the PD fluid, removing a biofilm from the PD catheter wall using a biofilm removing solution. The biofilm removing solution comprises: sodium citrate dihydrate; citric acid anhydrous; sodium lauryl sulfate; and water. In another aspect, a method for decontaminating a peritoneal dialysis (PD) catheter and removing a biofilm from the PD catheter and a transfer set, the method comprising: providing a biofilm removing solution; transferring the biofilm removing solution into a syringe; connecting the syringe to a transfer set of the PD catheter; and filling the transfer set and the PD catheter with the biofilm removing solution.
PLASTICIZER COMPOSITIONS COMPRISING DEHT AND EPOXIDIZED VEGETABLE OILS, PLASTICIZED COMPOSITIONS COMPRISING THE SAME, FILMS COMPRISING THE SAME, AND BAGS MANUFACTURED FROM FILMS COMPRISING THE SAME
The invention relates to plasticizer compositions comprising dioctyl terephthalate and epoxidized vegetable oils, plasticized compositions comprising the same, and particularly to bags formed from plasticized compositions including polyvinyl chloride comprising the same, which may be used for IV infusion, peritoneal dialysis, and the like.
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
A peritoneal dialysis ("PD") system includes a PD machine including a housing, a PD fluid pump housed by the housing, a plurality of PD fluid lines, and a plurality of PD fluid line connectors positioned and arranged at the housing to accept distal ends of the PD fluid lines to perform a disinfection sequence. The PD system also includes a disinfection unit including a disinfection unit housing, a PD fluid line connector positioned and arranged at the disinfection unit housing for receiving one of the PD fluid lines of the PD machine for the disinfection sequence, a line extending from the disinfection unit housing for connecting to one of the PD fluid line connectors of the PD machine for the disinfection sequence, and a disinfection fluid pump housed by the disinfection unit for pumping disinfection fluid during the disinfection sequence.
A peritoneal dialysis ("PD") system includes a housing, a PD fluid pump housed by the housing, and a reusable patient line extending from the housing. The reusable patient line includes a distal end configured to be connected to a patient line connector provided by the housing. The PD system also includes at least one reusable PD fluid line extending from the housing, the at least one reusable PD fluid line including a distal end configured to be connected to a PD fluid line connector provided by the housing. The PD system further includes a control unit configured to cause the PD fluid pump to apply a negative pressure to at least one of the reusable patient line or the at least one reusable PD fluid line when connected, respectively, to the patient line connector or the PD fluid line connector.
A peritoneal dialysis ("PD") system includes a PD fluid pump, a dual lumen patient line including fresh and used PD fluid lumens, a filter set in fluid communication with the fresh and used PD fluid lumens, a valve provided either with a patient's transfer set or with the filter set, and a control unit configured, after a patient drain, to (i) prompt a patient or caregiver to close the valve when the valve is a manual valve, or (ii) cause the valve to close automatically when the valve is an electrically or pneumatically controlled valve. The control unit is further configured to cause the PD fluid pump, with the valve closed, to pump fresh, heated PD fluid into the fresh PD fluid lumen to displace unheated PD fluid from the fresh PD fluid lumen, through the filter set, into the used PD fluid lumen. A corresponding method is also disclosed.
A peritoneal dialysis ("PD") system includes a housing; a PD fluid pump housed by the housing; a filter set including a filter housing and a hydrophilic filter membrane dividing an upstream chamber from a downstream chamber; a dual lumen patient line including a fresh PD fluid lumen in fluid communication with the upstream chamber and a used PD fluid lumen in fluid communication with the downstream chamber; a pressure sensor positioned and arranged to provide a pressure sensor output indicative of pressure in the downstream chamber of the filter housing; and a control unit configured to perform a pressure integrity test on the hydrophilic filter membrane by monitoring the pressure sensor output over a period of time, the pressure sensor output indicative of a negative pressure created in the downstream chamber by the PD fluid pump. A pressure drop test for evaluating the filter membrane is also disclosed.
A peritoneal dialysis ("PD") system includes a PD fluid pump, a disinfection loop including the PD fluid pump, the disinfection loop including PD fluid used for disinfecting the disinfection loop, and an acid solution source positioned and arranged to supply an acid solution to the disinfection loop during disinfection using the PD fluid. The disinfection loop includes an airtrap and a pressure sensor positioned and arranged to sense PD fluid pressure during disinfection, the pressure sensor outputting to a control unit, the control unit configured to open at least one gas valve located along at least one gas line leading to an upper portion of the airtrap when the PD fluid pressure reaches or exceeds a threshold PD fluid pressure due to gas formation caused by mixing the acid solution with the PD fluid.
A peritoneal dialysis fluid circuit comprising a patient line, a delivery line configured to supply fresh dialysis fluid towards the patient line, a withdrawal line configured to withdraw spent dialysis fluid from the patient line, a first pump arranged on the delivery line and configured to supply fresh dialysis fluid towards the patient line, and a second pump arranged on the withdrawal line and configured to withdraw spent dialysis fluid from the patient line. The fluid circuit further comprises a control unit configured to perform a peritoneal dialysis procedure. The peritoneal dialysis procedure comprises commanding activation of the first pump at a first flow rate, and activation of the second pump at a second flow rate different from the first flow rate: the first pump and the second pump are active simultaneously to provide the first flow rate and the second flow rate.
Systems and methods are disclosed for verifying reference voltage and analog-to-digital converter ("ADC") values during medical fluid treatment. An example system comprises a control circuit including control ADC devices associated with respective control sensors to facilitate medical fluid treatment; and a protective circuit including protective ADC devices associated with protective sensors, wherein the control circuit and the protective circuit are galvanically isolated from one another; and a computing device having a memory and a processor. The computing device may be configured to initiate a pretreatment that exposes the control sensors and the protective sensors to common pretreatment conditions (e.g., temperature and pressure); receive, during the pretreatment, control ADC values and protective ADC values; and register an error for one or both of the control circuit or the protective circuit based on a comparison of a control ADC value with a protective ADC value.
A medical fluid system includes a medical fluid pump configured to pump a medical fluid; a tube through which medical fluid pumped by the medical fluid pump flows; a pinch valve positioned and arranged to occlude the tube to prevent medical fluid from flowing through the tube, the pinch valve including a motor; a current sensor positioned and arranged to sense a current drawn by the motor of the pinch valve; and a control unit operable with the current sensor to monitor the current drawn by the motor while the motor is causing the pinch valve to occlude the tube, the control unit configured to stop the motor when the monitored current indicates an occlusion of the tube.
A perforating connector assembly including a valve; and a perforating connector comprising a perforator accepted by the valve, the perforator including a spiked end and a lever, the lever including a projection, a shell extending around the perforator and the valve, the shell including a pre-activation opening and a post-activation opening, a spring held compressed during pre-activation by a tab of the lever being located within the pre-activation opening, and an actuator slidingly engaged to the shell, the actuator including a projection, the actuator translatable by a user so that the projection becomes aligned with the tab located within the opening, wherein the user is able to push the projection into the pre-activation opening to disengage the tab from the opening, and wherein the spring is able to decompress and translate the perforator so that the medical fluid container is accessed and the tab becomes located within the post-activation opening.
A hemodynamic management system, apparatus, and method are disclosed herein. An example hemodynamic management apparatus includes a display interface screen and a processor configured to access a patient medical record using a patient identifier and determine, from the patient medical record, a new infusion start event associated with an infusion pump that is fluidly connected to a patient. The processor also causes the display interface screen to display an infusion line mapping interface that shows a graphical illustration of a human body and potential access sites, prompt for selection of an access site within the infusion line mapping interface, and after receiving a selection of an access site, associate an infusion pump identifier and the selected access site. The processor also causes the display interface screen to display information from the new infusion start event in conjunction with the selected access site shown within the infusion line mapping interface.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
78.
PERITONEAL DIALYSIS SYSTEM AND METHOD FOR MINIMIZING PATIENT DRAIN PAIN
A peritoneal dialysis ("PD") system includes a PD fluid pump; a patient line for receiving used PD fluid pumped by the PD fluid pump during a patient drain; a pressure sensor positioned and arranged to sense a negative pressure associated with the PD fluid pumped during the patient drain; and a control unit configured to (i) determine or know a flowrate of the PD fluid pumped during the patient drain, (ii) determine an applied negative pressure at which the PD fluid pump is to pump the PD fluid during the patient drain, the applied pressure based on a pressure drop corresponding to the determined or known flowrate, and (iii) use sensed negative pressure from the pressure sensor to cause the PD fluid pump to pump the PD fluid during the patient drain at the applied negative pressure.
A medical fluid system includes a medical fluid pump configured to pump a medical fluid; electronics associated with the medical fluid pump or with other components of the medical fluid system; a thermoelectric heater positioned and arranged to heat medical fluid pumped by the medical fluid pump, the thermoelectric heater including a heated side and a cooled side; a heat exchanger through which medical fluid pumped by the medical fluid pump is heated, the heat exchanger positioned and arranged so as to be in thermal communication with the heated side of the thermoelectric heater; and a mounting plate, the electronics supported by the mounting plate, the mounting plate positioned and arranged so as to be in thermal communication with the cooled side of the thermoelectric heater.
A61M 5/44 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for cooling or heating the devices or media
B01F 23/47 - Mixing liquids with liquidsEmulsifying involving high-viscosity liquids, e.g. asphalt
B01F 25/421 - Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path
81.
WEARABLE HEADS-UP DISPLAY ("HUD") FOR A PHARMACY WORKFLOW MANAGEMENT SYSTEM
A wearable heads-up display ("HUD") for a pharmacy workflow management system is disclosed herein. An example HUD includes smart-glasses that are communicatively coupled to a client device. The smart-glasses include at least one camera and/or barcode scanner to record information needed for the verification of a medication dose during medication formulation preparation. The smart-glasses include at least one microphone to record voice commands. Further, the smart-glasses include at least one embedded display screen that shows sequential steps of a preparation protocol for guiding a pharmacy technician to prepare a medication dose. An application on the client device and/or the smart-glasses is configured to recognize and use voice commands to provide navigation for the embedded display screen. The voice commands may also be used to provide data entry for medication dose preparation verification. Gestures may be detected by the camera and translated by the application into navigation or data entry commands.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
G06Q 10/101 - Collaborative creation, e.g. joint development of products or services
G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling
G09B 5/02 - Electrically-operated educational appliances with visual presentation of the material to be studied, e.g. using film strip
G09B 19/00 - Teaching not covered by other main groups of this subclass
G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
G06Q 10/08 - Logistics, e.g. warehousing, loading or distributionInventory or stock management
82.
FIBRINOGEN AND THROMBIN SOLUTIONS FOR A FIBRIN SEALANT AND FIBRIN SEALANT KIT
Disclosed are a fibrinogen solution and a thrombin solution. The fibrinogen solution comprises fibrinogen at a concentration of at least 40 mg/ml, factor XIII, pharmaceutically acceptable additives and water. The dynamic viscosity of the fibrinogen solution measured at 20°C increases at most by 35% after storing the solution at 20°C for 30 days. The thrombin solution comprises thrombin, pharmaceutically acceptable additives and water. The thrombin activity decreases at most by 15% after storing the solution at 25°C for 14 days. Also disclosed is a fibrin sealant kit with a first container comprising the fibrinogen solution and a second container comprising the thrombin solution. Further, methods for preparing a fibrin sealant and methods for treating a wound are disclosed.
An analytical method for detecting presence of oxidizing substances by measuring degradation of peptides may include preparing a test preparation that includes a peptide and a sample. The peptide degrades in the presence of oxidizing substances. The method may include detecting impurities of the peptide in the test preparation in which detected impurities indicate presence of oxidizing substances in the sample. Examples include using high performance liquid chromatography to detect, identify, and quantify impurities of the peptide indicating presence of oxidizing substances in the sample. Exemplary oxidizing substances include peroxide-containing, chlorine-containing compounds, and bromine-containing compounds. Exemplary peptides include vasopressin.
A system, apparatuses, and methods are disclosed that provide pump interconnectivity for pain medication therapies. In an example embodiment, a system includes a patient-controlled analgesia ("PCA") pump, an infusion pump, and a hub device configured to connect to the PCA pump and the infusion pump. The hub device is configured to determine the PCA pump and the infusion pump are both communicatively connected to the hub device, enable the PCA pump and the infusion pump to communicate with each other for a pain medication therapy, and enable the infusion pump to deliver the fluid to the patient when the infusion pump detects a period between periodic PCA pump boluses.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A system and method for securing a pump are disclosed. The system includes a pump that contains a medicament delivery system, a processor operably coupled to the pump, a user interface in operable communication with the processor, a plurality of sensors in operable communication with the processor, and a housing. The housing includes a frame, a door, and a locking mechanism that can be selectively unlocked to allow the door to partially detach from the frame. The security system includes a swivel door assembly, which includes physical redundancies to selectively prevent access to the internal space of the swivel door assembly and a plurality of alarms. For example, in response to receiving an input from the plurality of sensors, the processor initiates at least one of the plurality of alarms to provide an indication to a user that an event has occurred.
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
A pharmaceutical premix formulation comprising from about 10 mcg/ml to about 70 mcg/ml epinephrine and a salt is described, wherein the formulation is an aqueous, premix formulation and has a pH from about 2 to about 6. Uses and systems including the epinephrine premix formulation are also provided.
The present disclosure is directed to a midazolam pharmaceutical premix formulation housed in a flexible container, comprising from about 0.4 mg/ml to about 1.1 mg/ml midazolam hydrochloride and sodium chloride, wherein the formulation has a pH from about 2.7 to about 3.5. Also disclosed herein are methods of sedating a human subject in need thereof using the premix formulation.
A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 31/5517 - 1,4-Benzodiazepines, e.g. diazepam condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
The present disclosure is directed to a pharmaceutical premix phenylephrine formulation comprising phenylephrine hydrochloride and a salt, e.g., sodium chloride, where the formulation has a pH from about 3.0 to 6.5. Also presented is a system containing an oxygen scavenger, a photosensitive overpouch, and a pharmaceutical premix phenylephrine formulation. Methods of treating hypotension, e.g., resulting primarily from vasodilation, in such settings as septic shock or anaesthesia, in a human subject are also described.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
89.
PERITONEAL DIALYSIS SYSTEM HAVING AIR-AIDED PUMPING SEQUENCES
A peritoneal dialysis ("PD") system having an air-aided pumping sequence is disclosed herein. In an example, a PD system includes a housing, a PD fluid pump housed by the housing, an airtrap, a fluid line extending from the airtrap, a fluid line valve positioned and arranged to operate with the fluid line, a gas line extending from an upper portion of the airtrap, and a gas line valve positioned and arranged to operate with the gas line. The system also includes a control unit configured to cause the fluid line valve to close, the gas line valve to open, and the PD fluid pump to pump gas from the airtrap into the gas line after a patient drain to create a pocket of gas in the fluid line and push residual used PD fluid towards a drain line.
A peritoneal dialysis ("PD") system includes a plurality of PD fluid components, a reusable PD fluid line selectively fluidly communicating with the PD fluid components, a source of PD fluid selectively fluidly communicating with the reusable PD fluid line, a source of anti-scaling fluid selectively fluidly communicating with the reusable PD fluid line, and a control unit configured to (i) operate the plurality of PD fluid components during treatment using PD fluid from the source heated to a treatment temperature, and (ii) circulate unused PD fluid heated to a disinfection temperature in combination with anti-scaling fluid from the source of anti-scaling fluid after treatment for disinfecting the plurality of PD fluid components and the reusable PD fluid line, the anti-scaling fluid provided in an amount configured to lower the pH of the unused PD fluid to a level below which precipitates are formed and above which the pH causes disinfection.
The invention provides a system for characterizing a patient including a substrate, a first electrode, a second electrode, and an electrical system. The electrical system is connected to the substrate and worn entirely on the patient's body. The electrical system in electrical contact with both the first and second electrodes and configured to inject an alternating electrical current through the first electrode and into the region of tissue. The electrical system is configured to measure a first electrical signal from the region of tissue through the second electrode. The electrical system is configured to measure a second electrical signal from the region of tissue. The first electrical signal or a signal determined therefrom indicates a resistance of the region of tissue and the second electrical signal or a signal determined therefrom indicates a reactance of the region of tissue.
A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
A61B 5/0295 - Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/0295 - Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
A tube occluder includes a body within which an end of the tube is attached; a twisting lug formed with or attached to the tube, the twisting lug including an outwardly extending shape; and a sleeve in rotational communication with the body, the sleeve including an internal profile that matingly engages the outwardly extending shape of the twisting lug, the sleeve rotatable relative to the body in a first direction such that the internal profile causes the twisting lug to twist the tube closed, the sleeve rotatable in a second direction such that the internal profile causes the twisting lug to twist the tube open. A tube occluding method includes enabling a user to rotate the sleeve relative to the body, causing the internal profile to turn the twisting lug and to twist the tube closed while the end of the tube remains secured within the body.
A peritoneal dialysis ("PD") system includes a disposable set including a pump chamber having a flexible sheet, one side of the flexible sheet positioned and arranged during operation to receive pneumatic pressure; and a cycler including at least one source of positive and negative pneumatic pressure for delivering pneumatic pressure to the pump chamber, an air flow sensor, a pneumatic pressure sensor, a temperature sensor, a plurality of fluid valves, and a control unit configured to integrate outputs from the air flow sensor, the pneumatic pressure sensor and the temperature sensor over time to determine an amount of fresh or used PD fluid discharged from the pump chamber under positive pneumatic pressure and via an open one of the plurality of fluid valves.
A flexible plug for a medical fluid comprises a sealing member including a flexible cylindrical section that extends to a head; a rigid member holder secured to the sealing member; and a rigid sealing cap including a wall defining an opening, the head of the sealing member sealed within the opening to prevent the flow of medical fluid through the flexible plug. The flexible plug is sealed, e.g., solvent bonded, within a port tube, sleeve port or a Y-connector to form a flexible plug assembly. The user grasps and twists or torques the rigid member holder and the rigid sealing cap through the port tube, sleeve port or a Y-connector to unseal the head from the opening to allow the flow of medical fluid through the flexible plug. A method of manufacturing the flexible plug and associated assembly is also disclosed.
A peritoneal dialysis ("PD") system (10) includes a PD machine (20); a patient line (50) (which may be a dual lumen patient line) extending from the PD machine (20); a filter set (100) in fluid communication with the patient line (50), the filter set (100) including a plurality of hollow fiber membranes (120, e.g., sterilizing grade or bacteria reduction hollow fiber membranes) positioned and arranged such that fresh PD fluid flows through porous walls of the hollow fiber membranes (120) prior to exiting the filter set (100).
A peritoneal dialysis ("PD") system (10) includes a PD machine (20); a patient line (50) extending from the PD machine (20); and a filter set (100) including a filter housing (102) having an upper housing plate (102u) and a lower housing plate (102l), and a filter membrane (112, such as a sterilizing grade or a bacteria reduction filter membrane) located between the upper housing plate (102u) and the lower housing plate (102l), the filter set (100) further including a lumen-side connector (104) configured to connect to the patient line (50), the lumen-side connector (104) connected to the filter housing (102) via at least one of a fresh PD fluid tube (106a) or a used PD fluid tube (106b). A method for manufacturing the filter set (100) is also disclosed.
A peritoneal dialysis ("PD") system (10) including a PD machine (20); a patient line (50) extending from the PD machine (20); and a filter set (100) in fluid communication with the patient line (50), the filter set (100) including a filter body (110, 150, 190) housing first and second filter membranes (112a, 112b, such as a sterilizing grade or bacteria reduction filter membranes), the filter body (110, 150, 190) configured to be placed in different arrangements such that fresh PD fluid (i) flows through the first filter membrane (112a) and then through the second filter membrane (112b) or (ii) splits and flows through first and second filter membranes (112a, 112b) in parallel.
A peritoneal dialysis ("PD") system (10) includes a PD machine (20); a patient line (50) extending from the PD machine (20); and a filter set (100) in fluid communication with the patient line (50), the filter set (100) including a filter membrane (120, e.g., a sterilizing grade filter membrane or a bacteria reduction filter membrane) positioned and arranged such that fresh PD fluid flows through the filter membrane (120) into a filtered fluid compartment (106f), wherein the filtered fluid compartment (106f) includes an outlet (106o) to a port (106p), and wherein the port (106p) is in fluid communication with a circumferential used PD fluid channel (106c) positioned and arranged to carry used PD fluid around the filter membrane (120) without contacting the filter membrane (120). A method for priming filter set (100) is also disclosed.
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