The invention relates to a terminally heat-sterilized multi-chamber container for parenteral nutrition, comprising a first chamber containing a macronutrient formulation and a second chamber comprising a vitamin B12 formulation, wherein the vitamin B12 formulation (a) is essentially free from glucose, amino acids, vitamin B1, ascorbyl palmitate and/or vitamin C; and (b) stably comprises vitamin B12 for at least 6 months at a temperature of from 1° C. to 40° C. and/or for at least 24 months at a temperature of 25° C.
A system and method are disclosed for training a neural network to predict remaining battery capacity. Measured battery parameters are collected over time from a battery, including voltage, current, temperature, remaining voltage, and full charge voltage. The measured parameters are preprocessed to generate input feature vectors, including determining a rate of change of voltage over time. A training data set is generated comprising the input feature vectors and corresponding target output vectors indicating low battery, very low battery, and depleted battery states. A neural network comprising an input layer, at least one hidden layer, and an output layer is initialized and trained by iterative forward propagation, loss computation, and backpropagation-based weight and bias updates. Training is terminated upon satisfaction of a predefined tolerance or a maximum number of iterations. The trained neural network is stored for use in generating battery alarm indications during battery discharge.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G01R 31/36 - Arrangements for testing, measuring or monitoring the electrical condition of accumulators or electric batteries, e.g. capacity or state of charge [SoC]
G01R 31/367 - Software therefor, e.g. for battery testing using modelling or look-up tables
G01R 31/3842 - Arrangements for monitoring battery or accumulator variables, e.g. SoC combining voltage and current measurements
H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
3.
PHYSIOLOGICAL SENSOR PATCH FOR MAKING COMPLEX MEASUREMENTS OF BIOIMPEDANCE
The invention provides a system for characterizing a patient including a substrate, a first electrode, a second electrode, and an electrical system. The electrical system is connected to the substrate and worn entirely on the patient's body. The electrical system in electrical contact with both the first and second electrodes and configured to inject an alternating electrical current through the first electrode and into the region of tissue. The electrical system is configured to measure a first electrical signal from the region of tissue through the second electrode. The electrical system is configured to measure a second electrical signal from the region of tissue. The first electrical signal or a signal determined therefrom indicates a resistance of the region of tissue and the second electrical signal or a signal determined therefrom indicates a reactance of the region of tissue.
The present disclosure sets forth biocompatible composition for use as a bone hemostat. The composition comprises thrombin and an alkylene oxide copolymer ("AOC") blend. The thrombin may be sourced from human thrombin, bovine thrombin, or recombinant origin. The AOC blend consists of Poloxamer 188 and Pluriol V-10. The Poloxamer 188 constitutes 45% by weight of the total AOC blend, and the Pluriol V-10 constitutes 55% by weight of the total AOC blend.
Mayo Foundation for Medical Education and Research (USA)
Inventor
Oppegard, Shawn Collin
Garcia, Unberto
Corrales Nogales, Carlos Alberto
Del Castillo, Jorge
Enerio, Jeshrene
Connell, Brian
Bowers, Steven
Porter, Ii, Ivan E.
Ritchie, Charles
Abstract
An insufflation apparatus for peritoneal dialysis is disclosed herein. An example insufflation apparatus includes a compressed gas container configured to hold a compressed gas. The compressed gas container includes an outlet. The insufflation apparatus also includes a pressure regulator fluidly coupled to the outlet of the compressed gas chamber and a compliance chamber, which is fluidly coupled to the pressure regulator via a first tube. The compliance chamber may be configured to reduce pressure fluctuations of the compressed gas. The insufflation apparatus may also include an insufflation needle fluidly coupled to the compliance chamber via a second tube. The insufflation needle may be configured for placement into a peritoneal cavity of a patient.
Medical device audible and visual alarm synchronization is disclosed herein. In an example, a system includes a first medical device configured to generate a first alarm signal according to a first frequency and a second medical device configured to generate a second alarm signal according to a second frequency that is configured to be out-of-sync with the first alarm signal. The first medical device provides the first alarm signal at the first frequency while the second medical device provides the second alarm signal at the second frequency such that the second alarm signal is out-of-sync with the first alarm signal. Providing alarms out-of-sync advantageously improves the detectability of different alarms by a patient or a clinician.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
The invention provides an IV system for monitoring a patient that is positioned on the patient's body. The IV system includes: 1) a catheter that inserts into the patient's venous system; 2) a pressure sensor connected to the catheter that measures physiological signals indicating a pressure in the patient's venous system; 3) a motion sensor that measures motion signals; and 4) a processing system that: i) receives the physiological signals from the pressure sensor; ii) receives the motion signals from the motion sensor; iii) processes the motion signals by comparing them to a pre-determined threshold value to determine when the patient has a relatively low degree of motion; and iv) process the physiological signals to determine a physiological parameter when the processing system determines that the motion signals are below the pre-determined threshold value.
A gasless spray tip assembly for mixing and dispensing multi-component compositions includes a body defining a cannula; an insert configured to fit within a portion of the cannula; and a cap configured to secure with the body. The cap includes a plurality of channels tangent to and in fluid communication with a hollow chamber and an outlet orifice in fluid communication with the hollow chamber. A width of each of the plurality of channels is between about 0.1 mm and 0.3 mm, and a diameter of the hollow chamber is between about 0.65 to about 0.85 mm.
A spray tip assembly for providing a viscous fluid includes a body comprising an outlet orifice; and an insert configured to fit within the body. The spray tip assembly comprises a plurality of channels tangent to and in fluid communication with a hollow chamber. Each of the plurality of channels has a length between about 0.4mm and about 1.0mm.
A spray tip assembly for providing a viscous fluid includes a body comprising an outlet orifice; and an insert configured to fit within the body. The spray tip assembly comprises a plurality of channels tangent to and in fluid communication with a hollow chamber. Each of the plurality of channels has a length between about 0.4 mm and about 1.0 mm.
B05B 1/34 - Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
A61B 17/00 - Surgical instruments, devices or methods
A gasless spray tip assembly for mixing and dispensing multi-component compositions includes a body defining a cannula; an insert configured to fit within a portion of the cannula; and a cap configured to secure with the body. The cap includes a plurality of channels tangent to and in fluid communication with a hollow chamber and an outlet orifice in fluid communication with the hollow chamber. A width of each of the plurality of channels is between about 0.1 mm and 0.3 mm, and a diameter of the hollow chamber is between about 0.65 to about 0.85 mm.
B05B 7/08 - Spray pistolsApparatus for discharge with separate outlet orifices, e.g. to form parallel jets, to form intersecting jets
B05B 7/24 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
14.
METHODS AND COMPOSITIONS FOR DECONTAMINATING PD CATHETERS
A method of performing peritoneal dialysis (PD), the method comprising: delivering a PD fluid to the peritoneal cavity of a patient through a PD catheter; dwelling the PD fluid within the peritoneal cavity; and while dwelling the PD fluid, removing a biofilm from the PD catheter wall using a biofilm removing solution. The biofilm removing solution comprises: sodium citrate dihydrate; citric acid anhydrous; sodium lauryl sulfate; and water. In another aspect, a method for decontaminating a peritoneal dialysis (PD) catheter and removing a biofilm from the PD catheter and a transfer set, the method comprising: providing a biofilm removing solution; transferring the biofilm removing solution into a syringe; connecting the syringe to a transfer set of the PD catheter; and filling the transfer set and the PD catheter with the biofilm removing solution.
A fluid system includes a fluid pump comprising a fluid contacting portion and an actuating portion for actuating the fluid contacting portion. The fluid system also includes a pressure sensor having a diaphragm separating a first side of the pressure sensor in fluid communication with the fluid contacting portion of the fluid pump from a second side of the pressure sensor in operable communication with a pressure transducer. The fluid system also includes a control unit configured to cause the diaphragm to be moved to a starting position and actuate the actuating portion of the fluid pump to cause the fluid contacting portion to pump over a full range of positive and negative pressures to determine if the diaphragm flexes over the full range. When the diaphragm flexes over the full range, the control unit uses the starting position of the diaphragm for an upcoming operation of the fluid system.
A peritoneal dialysis system includes a control unit configured to (i) store a sleep state pattern for the patient, (ii) begin a patient drain followed by a patient fill when at least one sensor indicates that the patient is in a deep sleep state, (iii) extend a dwell period if the sleep state pattern indicates that the patient will enter a subsequent deep sleep state within a first time duration after a programmed dwell period, and (iv) shorten the dwell period if the sleep state pattern indicates that the patient will leave the deep sleep state within a second time duration after an end of the programmed dwell period. The system alternatively or additionally assesses or records a stress level of and/or a fluid/caloric intake by the patient and takes actions accordingly.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
18.
PERITONEAL DIALYSIS CYCLER HAVING DECREASED PH DISINFECTION
A peritoneal dialysis (“PD”) system includes a plurality of PD fluid components, a reusable PD fluid line selectively fluidly communicating with the PD fluid components, a source of PD fluid selectively fluidly communicating with the reusable PD fluid line, a source of anti-scaling fluid selectively fluidly communicating with the reusable PD fluid line, and a control unit configured to (i) operate the plurality of PD fluid components during treatment using PD fluid from the source heated to a treatment temperature, and (ii) circulate unused PD fluid heated to a disinfection temperature in combination with anti-scaling fluid from the source of anti-scaling fluid after treatment for disinfecting the plurality of PD fluid components and the reusable PD fluid line, the anti-scaling fluid provided in an amount configured to lower the pH of the unused PD fluid to a level below which precipitates are formed and above which the pH causes disinfection.
A Doppler blood flow monitoring device includes a signal generation module, a signal reception module, a signal filtration module, a signal conversion module, at least one speaker, and a user interface. The signal generation module is configured to send a signal to a probe positioned in a probe receptacle on a vascular coupler positioned about a patient's vessel. The signal reception module is configured to receive a return signal from the probe. The signal filtration module is configured to filter the return signal. The signal conversion module is configured to convert the filtered signal into an audible indication and a visual indication corresponding to a characteristic of blood flow in the patient's vessel. The at least one speaker is configured to emit the first audible indication. Additionally, the user interface is configured to display the visual indication.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
G01F 1/663 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters by measuring Doppler frequency shift
An inline heating system for a dialysis machine is disclosed. In an example, the inline heating system includes an inline heater comprising a heater element. The inline heating system also includes a control unit configured to compare a rate of change in heater element resistance to a set maximum rate of change in heater element resistance as part of a no flow or low flow condition detection algorithm implemented by the control unit. Power applied to the inline heater is stopped when a no flow or low flow condition is detected using the no flow or low flow condition detection algorithm to prevent overheating of the inline heater.
A packaged, sealed container system for stable storage of a formulation of an oxygen-sensitive pharmaceutical compound, the packaged, sealed container system comprising a primary container including therein a formulation of an oxygen-sensitive pharmaceutical compound, a secondary outer container comprising a first flexible sheet layer, an opposing second flexible sheet layer, and a seal disposed along a common peripheral edge of the first and second flexible sheet layers, such that the primary container is disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. An oxygen scavenger is also disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. The oxygen scavenger is in fluid communication with the contents of the primary container.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
B65D 75/28 - Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
B65D 81/26 - Adaptations for preventing deterioration or decay of contentsApplications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, fluids, e.g. exuded by contentsApplications of corrosion inhibitors or desiccators
22.
MEDICAL FLUID DELIVERY SYSTEM INCLUDING A MOBILE PLATFORM FOR PATIENT ENGAGEMENT AND TREATMENT COMPLIANCE
A platform for patient engagement and treatment compliance is disclosed. In an example, a mobile communication device includes an application that enables a patient to record treatment information for a peritoneal dialysis (“PD”) treatment. The application causes the mobile communication device to display a first user interface including first fields for a patient to enter (i) at least one blood pressure value and (ii) a heart rate value. After (i) to (ii) are entered into the first user interface, the application causes the mobile communication device to display a second user interface including second fields for the patient to enter (iii) a drain volume value and (iv) a fill volume value. After (iii) and (iv) are entered into the second user interface, the application transmits a message to a clinician server including (i) to (iv) as the treatment information for the PD treatment.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G06K 19/06 - Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
23.
SYSTEMS AND METHODS FOR OCCLUSION DETECTION IN INFUSION PUMPS
Systems and methods for detecting an occlusion in an infusion device are disclosed. One method includes generating, during an infusion session at predetermined intervals, a feature vector comprising an initial measurement of a physical force caused by fluid motion through an infusion device at the start of an infusion session, a current measurement of the physical force, a long term change in the measurement of the physical force, and a short term change in the measurement of the physical force. The feature vector is inputted, during the predetermined intervals, into a support vector machine (“SVM”) to output an indication of a presence or an absence of an occlusion in the infusion device. The SVM may be trained using reference data from reference infusion sessions having known consequences regarding the presence or the absence of an occlusion at various times during the reference infusion sessions.
An aseptically prepared pharmaceutically acceptable azithromycin premix formulation has a pH value of 5.5 to 7.5, preferably 6.0 to 7.0, more preferably 6.3 to 7.0, even more preferably 6.3 to 6.7, for example about 6.5. Preferred embodiments of the aseptically prepared pharmaceutically acceptable azithromycin premix formulation contain azithromycin, a buffering agent, water and optionally a tonicity adjusting agent and are stable for one month, three months, six months, nine months, twelve months, fifteen months, eighteen months or even twenty-four months, during storage at refrigerated temperatures, such as about 5° C., even without any additional components beyond the azithromycin, the buffering agent, and the optional tonicity adjusting agent in the premix formulation. The pharmaceutically acceptable azithromycin premix formulation may be aseptically filled into a container, preferably a glass or flexible container, to form a sterile pharmaceutical azithromycin premix product which does not undergo terminal sterilization. The azithromycin premix product can be a single use premix which is a sterile, stable and ready-to-use aqueous solution for parenteral administration, for example intravenous (IV) administration such as IV infusion, and requires no dilution prior to parenteral administration.
An infusion pumping mechanism includes a motor, a plurality of pump fingers and an opposing plate. Each finger of the pump fingers includes a body portion and a head portion. The head portion includes a tip that is configured to contact and occlude a tube installed in the pumping mechanism. The opposing plate includes an anvil with a plurality of force concentrators. A force concentrator of the plurality of force concentrators corresponds to a respective pump finger of the plurality of pump fingers. Additionally, the force concentrator includes a concentration surface configured to contact and occlude the tube. The force concentrator is aligned with a tip of the respective pump finger such that as the finger is directed towards the tube and contacts the tube, both the tip and the force concentrator provide pressure to opposite sides of the tube and at least partially occlude the tube.
Parenteral nutrition formulations for pediatric patients are disclosed. The nutritional formulations include a lipid for mulation that comprises an aqueous phase and an oil phase, wherein the lipid formulation is in the form of an oil-in-water emulsion. Multi-chamber containers for parenteral nutrition administration comprising a carbohydrate formulation present in a first chamber, an amino acid formulation present in a second chamber, and the lipid formulation present in a third chamber also are disclosed.
A61K 9/00 - Medicinal preparations characterised by special physical form
A23B 20/10 - Preservation of edible oil or fat compositions containing an aqueous phase, e.g. margarines
A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
A23D 7/01 - Other fatty acid esters, e.g. phosphatides
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
A23L 33/11 - Plant sterols or derivatives thereof, e.g. phytosterols
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
A61K 31/14 - Quaternary ammonium compounds, e.g. edrophonium, choline
A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
A61K 31/232 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A61K 36/05 - Chlorophycota or chlorophyta (green algae), e.g. Chlorella
A peritoneal dialysis system comprises a cycler including an air pump; a heater housing including a heater and an expandable bladder in fluid communication with the air pump, wherein the heater housing is sized to receive a heater bag between a wall of the housing and the expandable bladder; a plurality of nesting containers configured for fluid communication with the air pump a disposable set operable with the cycler and including the heater bag and a plurality of fluid supply bags for placement within the plurality of nesting containers; and a control unit programmed to control the air pump and the heater.
A system includes at least one infusion pump, an EMR server, an analysis engine, and a communication server. The analysis engine is configured to receive programming parameters and patient information from at least one of the infusion pump(s) and the EMR server. The analysis engine further configured to use at least one machine learning model configured to detect errors and abnormalities of programming parameters to generate an alert based, at least in part, on the programming parameters and the patient information. The communication server is communicatively coupled to a database and configured to both send and receive information from the infusion pump(s) and the analysis engine. The information received from the analysis engine includes the alert, which is saved in the database and transmitted to the infusion pump(s).
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
30.
INFUSION PUMP ERROR DETECTION AND ALERT COMMUNICATION SYSTEMS AND METHODS
A system includes at least one infusion pump, an EMR server, an analysis engine, and a communication server. The analysis engine is configured to receive programming parameters and patient information from at least one of the infusion pump(s) and the EMR server. The analysis engine further configured to use at least one machine learning model configured to detect errors and abnormalities of programming parameters to generate an alert based, at least in part, on the programming parameters and the patient information. The communication server is communicatively coupled to a database and configured to both send and receive information from the infusion pump(s) and the analysis engine. The information received from the analysis engine includes the alert, which is saved in the database and transmitted to the infusion pump(s).
The present disclosure relates to a terminally heat-sterilized ready-to-use parenteral nutrition formulation comprising all macronutrients and micronutrients required to meet the clinical guidelines for parenteral nutrition, wherein all said micronutrients and macronutrients are provided in one multi-chamber bag (MCB). The disclosure is also directed to a parenteral nutrition formulation comprising all such macronutrients and micronutrients. More specifically, the present disclosure is directed to a MCB comprising at least five chambers containing a carbohydrate formulation in a first chamber, an amino acid formulation in a second chamber, a lipid formulation in a third chamber, a fourth chamber comprising a vitamin formulation and a fifth chamber comprising a trace element formulation, wherein the carbohydrate formulation, amino acid formulation and/or the lipid formulation may also contain certain vitamins and certain trace elements that can be stably accommodated therein.
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
A23B 2/30 - Preservation of foods or foodstuffs, in general by heating materials in packages which are not progressively transported through the apparatus
A23L 33/115 - Fatty acids or derivatives thereofFats or oils
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
A61J 1/20 - Arrangements for transferring fluids, e.g. from vial to syringe
32.
DESIGN AND LOGIC TO DETECT INFUSION PUMP VERTICAL DISPLACEMENT AND MEASURE UNINTENDED BOLUS, MISSING VOLUME, TIME WITHOUT INFUSION, AND OTHER PARAMETERS
Improved medical pump designs, systems, and logic to detect medical pump vertical displacement are provided. The relative position of the pump with respect to an initial position set by a user may be measured. The designs, systems, and logic may also be used to detect the change in the height of a patient relative to the medical pump during therapy by measuring hydrostatic pressure in a patient line. The detected change in vertical displacements can be used to determine the volume of an unintended bolus or a missing volume during infusion therapy. The therapy may be adjusted based on the unintended bolus or missing volume as desired. The designs, systems, and logic may further include a transport mode to help maintain consistent therapy while a patient is ambulated or the pump is moved.
The present disclosure relates to improved lipid emulsions for providing parenteral nutrition, including ready-to-use parenteral nutrition formulations comprising such lipid emulsions. More particularly, the present disclosure is directed to improved lipid formulations or emulsions including multi-chamber containers comprising same, wherein the lipid emulsion contains DHA, EPA, and ARA in an optimized concentration and ratio, optionally in combination with choline and defined levels of phytosterols. The present disclosure further relates to methods of avoiding and/or treating liver damage and/or inflammation, and to methods for improving fatty acid profiles in plasma and certain tissues or organs especially of pediatric patients.
A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
A23L 33/115 - Fatty acids or derivatives thereofFats or oils
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/14 - Quaternary ammonium compounds, e.g. edrophonium, choline
A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
34.
PLASTICIZER COMPOSITIONS COMPRISING DEHT AND EPOXIDIZED VEGETABLE OILS, PLASTICIZED COMPOSITIONS COMPRISING THE SAME, FILMS COMPRISING THE SAME, AND BAGS MANUFACTURED FROM FILMS COMPRISING THE SAME
The invention relates to plasticizer compositions comprising dioctyl terephthalate and epoxidized vegetable oils, plasticized compositions comprising the same, and particularly to bags formed from plasticized compositions including polyvinyl chloride comprising the same, which may be used for IV infusion, peritoneal dialysis, and the like.
A medical device data back-association system, apparatuses, and methods are disclosed. In an example embodiment, a server receives, while an infusion pump is administering a medication to a patient, an identifier message including at least two of a device identifier of the infusion pump, a patient identifier of the patient, and a medication order identifier of a medication being administered by the infusion pump. The server prompts a clinician device for creating an association between an electronic medical record (“EMR”) of the patient and the infusion pump. When an association to be created, the server uses contents of the identifier message to create the association. For subsequently received infusion pump data, the server stores this infusion pump data to the EMR of the patient based on the created association between the EMR of the patient and the infusion pump.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
36.
DESIGN AND LOGIC TO DETECT INFUSION PUMP VERTICAL DISPLACEMENT AND MEASURE UNINTENDED BOLUS, MISSING VOLUME, TIME WITHOUT INFUSION, AND OTHER PARAMETERS
Improved medical pump designs, systems, and logic to detect medical pump vertical displacement are provided. The relative position of the pump with respect to an initial position set by a user may be measured. The designs, systems, and logic may also be used to detect the change in the height of a patient relative to the medical pump during therapy by measuring hydrostatic pressure in a patient line. The detected change in vertical displacements can be used to determine the volume of an unintended bolus or a missing volume during infusion therapy. The therapy may be adjusted based on the unintended bolus or missing volume as desired. The designs, systems, and logic may further include a transport mode to help maintain consistent therapy while a patient is ambulated or the pump is moved.
The present disclosure provides a new and innovative method for dynamically managing power and charging rates of multi-pump assemblies. In various embodiments, a management system accesses a first charging profile for a first infusion pump and a different, second charging profile for a second infusion pump. The first charging profile specifies times that the first infusion pump is to enter a charge state and times the first infusion pump is to enter a no charge state. The second charging profile specifies times that the second infusion pump is to enter a charge state and times the second infusion pump is to enter a no charge state. The management system uses the respective charging profile to cause the first infusion pump to charge according to the first charging profile and the second infusion pump to charge according to the second charging profile.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
An introducer assembly for applying a film at a surgical site includes a winding rod with a shaft that extends from a handle. The handle is located at a proximal end of the winding rod and includes a plurality of raised protrusions. The shaft includes a slit located at its distal end. The shaft of the winding rod has a dumbbell-shaped cross-section. The introducer assembly also includes an outer cannula assembly with a metallic tube coupled to a molded grip located at the proximal end of the metallic tube. The metallic tube includes a slit at its distal end and a notch at its proximal end; the notch is configured to mate with a tab on the molded grip for rotational clocking. The molded grip includes at least one substantially flat surface to prevent rolling, and includes a plurality of ribs radiating from the surface of the molded grip.
A61B 17/00 - Surgical instruments, devices or methods
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
39.
MANUFACTURABILITY IMPROVEMENTS FOR LAPAROSCOPIC INTRODUCER
An introducer assembly for applying a film at a surgical site includes a winding rod with a shaft that extends from a handle. The handle is located at a proximal end of the winding rod and includes a plurality of raised protrusions. The shaft includes a slit located at its distal end. The shaft of the winding rod has a dumbbell-shaped cross-section. The introducer assembly also includes an outer cannula assembly with a metallic tube coupled to a molded grip located at the proximal end of the metallic tube. The metallic tube includes a slit at its distal end and a notch at its proximal end; the notch is configured to mate with a tab on the molded grip for rotational clocking. The molded grip includes at least one substantially flat surface to prevent rolling, and includes a plurality of ribs radiating from the surface of the molded grip.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/313 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
A non-ratcheting surgical clip application device for applying and crimping surgical clips to ligate a vessel. The surgical clip applying device includes an enclosure formed from a top housing, a bottom housing and a window cover, a pair of handles including a left handle and a right handle each mounted for pivotal movement in the bottom housing, a main rail fixedly mounted to the bottom housing within the enclosure, a pair of clip applying jaws fixedly attached to the bottom housing and mounted through the main rail, a jaw closer comprising a proximal end, a distal end, and an elongate base, and a drive mechanism including a plurality of levers and at least one spring.
A61B 17/128 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips
A61B 17/00 - Surgical instruments, devices or methods
41.
AIR-POWERED PERITONEAL DIALYSIS SYSTEM WITH INFLATABLE BLADDERS
A peritoneal dialysis system includes a cycler having one or more air pump; a slotted housing including a plurality of slots each having a first side and a second side, wherein each respective slot of the plurality of slots includes a first expandable bladder fixed to the first side, and wherein each respective slot of the plurality of slots is configured to receive a fluid supply bag between the first expandable bladder and the second side, and a heater housing sized to hold a second expandable bladder, and wherein the heater housing is configured to receive a fluid heater bag adjacent to the second expandable bladder, wherein the one or more air pump is in fluid communication with the respective first expandable bladders and the second expandable bladder; and a disposable set operable with the cycler.
A61M 5/148 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons flexible
A61M 5/44 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for cooling or heating the devices or media
A non-ratcheting surgical clip application device for applying and crimping surgical clips to ligate a vessel. The surgical clip applying device includes an enclosure formed from a top housing, a bottom housing and a window cover, a pair of handles including a left handle and a right handle each mounted for pivotal movement in the bottom housing, a main rail fixedly mounted to the bottom housing within the enclosure, a pair of clip applying jaws fixedly attached to the bottom housing and mounted through the main rail, a jaw closer comprising a proximal end, a distal end, and an elongate base, and a drive mechanism including a plurality of levers and at least one spring.
A61B 17/128 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips
43.
PERITONEAL DIALYSIS SYSTEM AND METHOD FOR MANAGING PATIENT DRAIN PAIN
A peritoneal dialysis (“PD”) system includes a PD fluid pump; a patient line for receiving used PD fluid pumped by the PD fluid pump during a patient drain; a control unit configured to cause the PD fluid pump to pump, according to a first commanded pressure, the used PD fluid through the patient line during the patient drain; and a personal digital assistant (“PDA”) in wireless communication with the control-unit, the PDA configured to enable a patient while undergoing the patient drain to send a command to the control unit, the command instructing the control unit to cause the PD fluid to pump according to a second commanded pressure during the patient drain.
Improved medical dose preparation work stations and accessories are described. The medical dose preparation work station includes a camera for capturing medical dose preparation images (e.g., to document preparation of a mediation dose). The camera may be actuated by an operator using a plurality of membrane buttons on a base of the medical dose preparation work station. The medical dose preparation work station further includes an adjustable arm to hold the camera at a desired focal length from a staging area defined by a tray such that objects in the images from the camera remain in focus. The tray includes a light side and a dark side configured to provide a high contrast background for an operator and for the camera.
A61J 7/00 - Devices for administering medicines orally, e.g. spoonsPill counting devicesArrangements for time indication or reminder for taking medicine
H04N 7/18 - Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
An intraperitoneal pressure (“IPP”) measurement apparatus is disclosed herein. In an example, the IPP measurement apparatus includes a transfer set and s catheter that are fluidly coupled to a patient's peritoneal cavity and a spirometer for transmitting output data indicative of a volume of air inspired and expired by a patient's lungs. The IPP measurement apparatus also includes a processor configured to record the output data from the spirometer during dwell intervals between when PD fluid is provided to and removed from the patient's peritoneal cavity. The processor is also configured to use a correlation between lung capacity and IPP to determine at least one of IPP or a fill volume parameter based on at least the output data from the spirometer.
Improved medical dose preparation work stations and accessories are described. The medical dose preparation work station includes a camera for capturing medical dose preparation images (e.g., to document preparation of a mediation dose). The camera may be actuated by an operator using a plurality of membrane buttons on a base of the medical dose preparation work station. The medical dose preparation work station further includes an adjustable arm to hold the camera at a desired focal length from a staging area defined by a tray such that objects in the images from the camera remain in focus. The tray includes a light side and a dark side configured to provide a high contrast background for an operator and for the camera.
A61G 12/00 - Accommodation for nursing, e.g. in hospitals, not covered by groups , e.g. trolleys for transport of medicaments or foodPrescription lists
A61J 3/00 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
A61J 7/00 - Devices for administering medicines orally, e.g. spoonsPill counting devicesArrangements for time indication or reminder for taking medicine
G01G 23/37 - Indicating the weight by electrical means, e.g. using photoelectric cells involving digital counting
G01N 21/88 - Investigating the presence of flaws, defects or contamination
G06Q 10/0639 - Performance analysis of employeesPerformance analysis of enterprise or organisation operations
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
47.
PERITONEAL DIALYSIS SYSTEM HAVING AIR-AIDED PUMPING SEQUENCES
A peritoneal dialysis (“PD”) system having an air-aided pumping sequence is disclosed herein. In an example, a PD system includes a housing, a PD fluid pump housed by the housing, an airtrap, a fluid line extending from the airtrap, a fluid line valve positioned and arranged to operate with the fluid line, a gas line extending from an upper portion of the airtrap, and a gas line valve positioned and arranged to operate with the gas line. The system also includes a control unit configured to cause the fluid line valve to close, the gas line valve to open, and the PD fluid pump to pump gas from the airtrap into the gas line after a patient drain to create a pocket of gas in the fluid line and push residual used PD fluid towards a drain line.
A peritoneal dialysis (“PD”) system includes a PD fluid pump; a patient line for receiving used PD fluid pumped by the PD fluid pump during a patient drain; a pressure sensor positioned and arranged to sense a negative pressure associated with the PD fluid pumped during the patient drain; and a control unit configured to (i) determine or know a flowrate of the PD fluid pumped during the patient drain, (ii) determine an applied negative pressure at which the PD fluid pump is to pump the PD fluid during the patient drain, the applied pressure based on a pressure drop corresponding to the determined or known flowrate, and (iii) use sensed negative pressure from the pressure sensor to cause the PD fluid pump to pump the PD fluid during the patient drain at the applied negative pressure.
A peritoneal dialysis (“PD”) transfer set includes a base having at least one slot; a slider extending within the base and including an elongated tube configured to carry PD fluid, the elongated tube extending to a head of the slider, the head including at least one lug extending through the at least one slot and further including a connector for connecting to a mating patient line connector; and a shroud barrel including at least one helical groove and extending around a portion of the base so that the at least one helical groove receives the at least one lug, wherein a user may rotate the shroud barrel including the at least one helical groove such that the at least one lug extends along the at least one helical groove, the at least one slot constraining movement of the at least one lug and the slider to being a translational movement.
A peritoneal dialysis system and method are disclosed. The peritoneal dialysis system includes a pressure chamber and a flexible container located within the pressure chamber. The peritoneal dialysis system also includes a motive fluid cylinder, a piston located within the motive fluid cylinder, and a linear actuator configured to extend and retract the piston. The peritoneal dialysis system further includes at least one motive fluid valve for opening and closing a pressure chamber passage and a vent passage. Additionally, the peritoneal dialysis system includes a control unit in operable communication with the linear actuator and the at least one motive fluid valve. The control unit is configured to perform at least one of a negative pressure sequence and/or a positive pressure sequence for pumping peritoneal dialysis fluid.
A peritoneal dialysis system includes a chamber, a hydraulic pump including or operating with a hydraulic fluid storage area, an inflatable bladder located within the chamber and in hydraulic fluid communication with the hydraulic pump, and a control unit configured to cause known amounts of hydraulic fluid to be reuseably (i) pulled from the inflatable bladder into the hydraulic fluid storage area in a draw stroke in which fresh or used dialysis fluid is pulled into the flexible container, and (ii) pushed from the hydraulic fluid storage area into the inflatable bladder in a discharge stroke in which fresh or used dialysis fluid is pushed from the flexible container.
A capacitive priming sensor for a medical fluid delivery system is disclosed. In an example embodiment, a priming sensor includes a housing including a recessed section configured to accept a portion of a patient tube. The housing includes a first electrode located adjacent to a portion of the patient tube when the portion of the patient tube is inserted into the housing and a second electrode located above the first electrode. The priming sensor also includes a capacitive sensor that measures a capacitance between the first electrode and the second electrode. A processor operates with the capacitive sensor and is configured to use the measured capacitance to determine a transition between a no-tube state and a dry tube state. The processor then causes a pump to pump dialysis fluid through the patient tube for a priming sequence after the dry tube state is determined
Disclosed are a fibrinogen solution and a thrombin solution. The fibrinogen solution comprises fibrinogen at a concentration of at least 40 mg/ml, factor XIII, pharmaceutically acceptable additives and water. The dynamic viscosity of the fibrinogen solution measured at 20° C. increases at most by 35% after storing the solution at 20° C. for 30 days. The thrombin solution comprises thrombin, pharmaceutically acceptable additives and water.
A peritoneal dialysis (“PD”) system includes a PD fluid pump, a PD fluid heater positioned and arranged to heat fresh PD fluid pumped by the PD fluid pump, and a phase change material (“PCM”) device positioned and arranged to receive fresh PD fluid heated by the PD fluid heater. The PCM device includes a PCM having a melting temperature selected so that the PCM melts when overheated fresh PD fluid contacts the PCM, removing heat from the overheated fresh PD fluid.
An extracorporeal and drug delivery system includes a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line and a venous line, the machine including an effluent pump for pumping effluent from the blood filter, and at least one of a dialysis fluid pump for pumping dialysis fluid to the blood filter at a dialysis fluid flowrate, a predilution pump for pumping replacement fluid into the arterial line at a predilution flowrate, or a postdilution pump for pumping replacement fluid into the venous line at a postdilution flowrate; an infusion pump operable to deliver an intravenous (“IV”) drug to the patient; and a coordinating logic implementor configured to determine if a formulation adjustment should be made to the IV drug when a constituent of the IV drug exists in the dialysis fluid, the predilution replacement fluid, and/or the postdilution replacement fluid.
A method for extending the storage lifetime of a rechargeable battery located in a device is disclosed. The battery lifetime extension method includes providing a device that derives its power from a rechargeable battery. When the device is powered off by a user, a computer implemented program utilized by the device automatically powers up the device into a lower power mode upon expiration of a variable duration timer monitored by the computing unit that continuously repeats according to a programed duration cycle. The computer implemented program then evaluates a state of charge of the rechargeable battery, determines whether the state of charge of the rechargeable battery is above or below a variable programed threshold, and causes the rechargeable battery to remain in a low power state until a charge is applied to the rechargeable battery.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G06F 1/3212 - Monitoring battery levels, e.g. power saving mode being initiated when battery voltage goes below a certain level
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
A peritoneal dialysis (“PD”) machine includes a water pump, a concentrate pump, a water valve, a concentrate valve, a mixing line located downstream from the water pump and the concentrate pump, a conductivity sensor positioned to sense a mixture of purified water and PD fluid concentrate that at least partially forms fresh PD fluid, a flexible patient line configured to bring at least partially formed fresh PD fluid to a patient and remove used PD fluid from the patient, and a control unit configured to control the water pump, the concentrate pump, the water valve, and the concentrate valve. The control unit is also configured to receive an output from the conductivity sensor and run a disinfection sequence in which (i) the inlet to the concentrate valve instead receives disinfectant or (ii) the flexible patient line instead receives disinfectant.
A peritoneal dialysis system includes a cycler configured to pump peritoneal dialysis fluid and a disposable set configured to receive the peritoneal dialysis fluid pumped by the cycler. The disposable set includes a filter having a fresh peritoneal dialysis fluid pathway and a membrane located along the fresh peritoneal dialysis fluid pathway and configured to filter the peritoneal dialysis fluid. The filter also includes a grid housing comprising a plurality of baffles configured to separate filtered fresh peritoneal dialysis fluid that has flowed through the membrane into plural fluid channels that form an interior region of the fresh peritoneal dialysis fluid pathway.
A virtual assistant/chatbot to improve clinical workflow for home renal replacement therapies is disclosed herein. A virtual assistant/chatbot includes a user interface configured to enable a patient to engage in a virtual chat session by typing, speaking, or otherwise providing information regarding a patient request or issue related to their renal replacement therapy. The virtual assistant/chatbot also includes a server configured to provide logic to respond to the patient's requests. The logic defines a sequence of questions and answers for resolving patient queries. The sequence of assistant/chatbot questions and patient answers may be configured in a node arrangement such that certain patient answers/requests lead to additional questions for additional information from a patient. The virtual assistant/chatbot is configured to answer patient requests automatically or determine when the patient request is to be immediately addressed by a clinician or later through a phone call, text, or email communication.
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G10L 15/22 - Procedures used during a speech recognition process, e.g. man-machine dialog
H04L 51/02 - User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail using automatic reactions or user delegation, e.g. automatic replies or chatbot-generated messages
H04L 67/10 - Protocols in which an application is distributed across nodes in the network
A system and apparatus for securing a pump are disclosed. The system includes a patient-controlled analgesia ("PCA") pump, a security door, a security frame assembly, and a diversion guard. The PCA pump can be placed in the security frame assembly. The security door interlocks with the security frame assembly and pivots about it from an open configuration to a closed configuration. When the security door is in a closed configuration, the medicament-administering components of the PCA pump are out of reach from unauthorized users. As an additional physical barrier, the diversion guard selectively couples to the security frame assembly, such that it blocks a physical gap between the security door and security frame assembly when the security door is in a closed configuration.
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
A system and apparatus for securing a pump are disclosed. The system includes a patient-controlled analgesia (“PCA”) pump, a security door, a security frame assembly, and a diversion guard. The PCA pump can be placed in the security frame assembly. The security door interlocks with the security frame assembly and pivots about it from an open configuration to a closed configuration. When the security door is in a closed configuration, the medicament-administering components of the PCA pump are out of reach from unauthorized users. As an additional physical barrier, the diversion guard selectively couples to the security frame assembly, such that it blocks a physical gap between the security door and security frame assembly when the security door is in a closed configuration.
Methods, systems, and apparatus are disclosed herein for a PCA pump user interface that provides on-screen parameter programming guidance to prevent dosage errors. The example methods, systems, and apparatus are configured to display parameter range line graphs on a PCA pump user interface screen in accordance with the lower and upper limits established for a user-inputted parameter. Additionally, the example methods, systems, and apparatus are configured to generate and display user alerts and does not allow users to enter the parameter if it is not in acceptable range when a user inputted parameter value affects the range of values acceptable by a previously entered parameter value.
A method for decontaminating a peritoneal dialysis (PD) catheter and removing a biofilm from the PD catheter and a transfer set, the method including: providing a biofilm removing solution; transferring the biofilm removing solution into a syringe; fluidly communicating the syringe to a transfer set located along the PD catheter, and filling the transfer set and the PD catheter with the biofilm removing solution.
Methods, systems, and apparatus are disclosed herein for a PCA pump user interface that provides on-screen parameter programming guidance to prevent dosage errors. The example methods, systems, and apparatus are configured to display parameter range line graphs on a PCA pump user interface screen in accordance with the lower and upper limits established for a user-inputted parameter. Additionally, the example methods, systems, and apparatus are configured to generate and display user alerts and does not allow users to enter the parameter if it is not in acceptable range when a user inputted parameter value affects the range of values acceptable by a previously entered parameter value.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A wearable heads-up display (“HUD”) for a pharmacy workflow management system is disclosed herein. An example HUD includes smart-glasses that are communicatively coupled to a client device. The smart-glasses include at least one camera and/or barcode scanner to record verification information needed for the verification of a medication dose during medication formulation preparation. Further, the smart-glasses include at least one embedded display screen that shows sequential steps of a preparation protocol for guiding a pharmacy technician to prepare a medication dose. An application on the client device and/or the smart-glasses is configured to record the verification information obtained from the camera and/or barcode scanner for remote verification to ensure the medication dose was prepared properly.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
A peritoneal dialysis (“PD”) system includes a first volumetric balancing chamber including a first fixed volume chamber and a first diaphragm positioned and arranged to extend back and forth within the first fixed volume chamber, the first diaphragm separating a fresh PD fluid side from a used PD fluid side of the first volumetric balancing chamber; a second volumetric balancing chamber including a second fixed volume chamber and a second diaphragm positioned and arranged to extend back and forth within the second fixed volume chamber, the second diaphragm separating a fresh PD fluid side from a used PD fluid side of the second volumetric balancing chamber; and a PD fluid pump positioned and arranged to pump used PD fluid back and forth between the used PD fluid sides of the first and second volumetric balancing chamber.
A dialysis system includes a dialysis fluid metering pump; at least one volumetric balancing chamber including a first fixed volume chamber and a first diaphragm positioned and arranged to extend back and forth within the first volumetric balancing chamber; a first outlet line extending between the first volumetric balancing chamber and an inlet to the dialysis fluid metering pump; a second outlet line extending between the first volumetric balancing chamber and a drain line; a first inlet line extending between the first volumetric balancing chamber and an outlet from the dialysis fluid metering pump; a second inlet line extending between the first volumetric balancing chamber and a used dialysis fluid line.
A method for controlling a motorized pinch valve in a dialysis system is disclosed. In an example the method comprises (i) powering a motor of a motorized pinch valve such that a shaft of the motorized pinch valve moves in a direction to occlude a tube, (ii) monitoring, using a sensor, a sensor output characteristic indicative of a current drawn by the motor while powering the motor, (iii) when a change in the sensor output characteristic of an occlusion of the tube is not detected, returning to (i), and (iv) when a change in the sensor output characteristic of the occlusion of the tube is detected, depowering the motor.
The present invention provides a hemostatic composite sponge comprising oxidized cellulose and an essentially gelatin-free bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.
A61F 13/0203 - Adhesive bandages or dressings with fluid retention members
A61F 13/0246 - Adhesive bandages or dressings characterised by the skin-adhering layer
A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
H04W 4/14 - Short messaging services, e.g. short message service [SMS] or unstructured supplementary service data [USSD]
71.
MEDICAL FLUID THERAPY MACHINE INCLUDING SERVICING REGIME THEREFORE
A peritoneal dialysis system includes a control unit configured to cause (i) a fluid inlet valve and a fluid outlet valve to occlude a fluid inlet line and a fluid outlet line, respectively, while a linear actuator moves a piston to create a positive pressure within a pump housing, the positive pressure measured by a pressure sensor, and (ii) the fluid inlet valve to occlude the fluid inlet line and the fluid outlet valve to open the fluid outlet line, while the linear actuator moves the piston so as to maintain the positive pressure within the pump housing while fluid is pumped out of the fluid pump chamber via the opened fluid outlet line.
A peritoneal dialysis (“PD”) system includes a PD fluid pump; a disinfection loop including the PD fluid pump, the disinfection loop including PD fluid used for disinfecting the disinfection loop; and a carbon dioxide (CO2), source positioned and arranged to supply CO2 to the disinfection loop to inhibit and/or remove the production of calcium carbonate (CaCO3) during a disinfection sequence. The PD system includes a control unit configured to open a valve to allow CO2 to be supplied, wherein the control unit may use a lookup table or algorithm to determine the desired pressure or pressure increase.
A peritoneal dialysis system is disclosed. In an example, a peritoneal dialysis system includes a mixing container configured to accept purified water and peritoneal dialysis fluid concentrate to form fresh peritoneal dialysis fluid. The peritoneal dialysis system also includes a distillation unit comprising an unpurified water/used peritoneal dialysis fluid storage tank for receiving unpurified water and used peritoneal dialysis fluid. The distillation unit further includes a heater in fluid communication with the unpurified water/used peritoneal dialysis fluid storage tank. The heater is configured to boil the unpurified water and the used peritoneal dialysis fluid to form water vapor. The distillation unit additionally includes a condenser including a thermally conductive flowpath configured to accept and condense the water vapor and at least one finishing filter positioned to receive and further purify the condensed water vapor into purified water for use in the mixing container to form the fresh peritoneal dialysis fluid.
A61B 17/128 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips
A61B 17/00 - Surgical instruments, devices or methods
76.
AZITHROMYCIN PREMIX FORMULATION AND PRODUCT, METHODS OF PREPARING SAME, AND METHODS OF USING SAME
An aseptically prepared pharmaceutically acceptable azithromycin premix formulation has a pH value of 5.5 to 7.5, preferably 6.0 to 7.0, more preferably 6.3 to 7.0, even more preferably 6.3 to 6.7, for example about 6.5. Preferred embodiments of the aseptically prepared pharmaceutically acceptable azithromycin premix formulation contain azithromycin, a buffering agent, water and optionally a tonicity adjusting agent and are stable for one month, three months, six months, nine months, twelve months, fifteen months, eighteen months or even twenty-four months, during storage at refrigerated temperatures, such as about 5 °C, even without any additional components beyond the azithromycin, the buffering agent, and the optional tonicity adjusting agent in the premix formulation. The pharmaceutically acceptable azithromycin premix formulation may be aseptically filled into a container, preferably a glass or flexible container, to form a sterile pharmaceutical azithromycin premix product which does not undergo terminal sterilization. The azithromycin premix product can be a single use premix which is a sterile, stable and ready-to-use aqueous solution for parenteral administration, for example intravenous (IV) administration such as IV infusion, and requires no dilution prior to parenteral administration.
A peritoneal dialysis system having a drain purge is disclosed. The peritoneal dialysis system comprises a cycler including a pump, a patient line positioned to fluidly communicate with the pump, and a drain container positioned to fluidly communicate with the pump. The peritoneal dialysis system also comprises a control unit configured to operate the pump during a peritoneal dialysis treatment to cause (i) used dialysis fluid to be pumped from a patient through the patient line to the drain container, and (ii) at an end of the peritoneal dialysis treatment, the used dialysis fluid to be pumped from the drain container, through the patient line, to a house drain.
An aqueous pharmaceutical composition suitable for parenteral administration and having enhanced storage stability includes between about 0.1 mg/mL and about 40 mg/mL micafungin; (ii) between about 0.1 mM and 400 mM buffering agent; and (iii) between about 0 mg/mL and about 500 mg/mL tonicity adjusting agent, wherein the pH of the composition is between about 3.0 and 7.0, for example, between about 3.5 and 7.0.
A water supply system is operable to extract liquid water, EW, from waste fluid, WF, generated by a dialysis system and to provide the liquid water for use by the dialysis system. The water supply system comprises a dehumidifier sub-system and a humidifier sub-system. A gas stream is circulated between the sub-systems and is alternately humidified and dehumidified. The liquid water is extracted from the gas stream by the dehumidifier sub-system. The humidifier sub-system comprises a membrane distillation unit with a feed side and a draw side separated by a hydrophobic membrane. The waste fluid is supplied on the feed side and the gas stream is supplied on the draw side, and water vapor is transported from the waste fluid through the membrane via a difference in partial water vapor pressure between the feed and draw sides.
An aseptically prepared pharmaceutically acceptable azithromycin premix formulation has a pH value of 5.5 to 7.5, preferably 6.0 to 7.0, more preferably 6.3 to 7.0, even more preferably 6.3 to 6.7, for example about 6.5. Preferred embodiments of the aseptically prepared pharmaceutically acceptable azithromycin premix formulation contain azithromycin, a buffering agent, water and optionally a tonicity adjusting agent and are stable for one month, three months, six months, nine months, twelve months, fifteen months, eighteen months or even twenty-four months, during storage at refrigerated temperatures, such as about 5° C., even without any additional components beyond the azithromycin, the buffering agent, and the optional tonicity adjusting agent in the premix formulation. The pharmaceutically acceptable azithromycin premix formulation may be aseptically filled into a container, preferably a glass or flexible container, to form a sterile pharmaceutical azithromycin premix product which does not undergo terminal sterilization. The azithromycin premix product can be a single use premix which is a sterile, stable and ready-to-use aqueous solution for parenteral administration, for example intravenous (IV) administration such as IV infusion, and requires no dilution prior to parenteral administration.
A valve seat for a disposable medical fluid cassette is disclosed herein. The valve seat comprises a rigid wall and a tapered sealing surface extending from the rigid wall. The tapered sealing surface surrounds an opening formed in the rigid wall. The valve seat also comprises a plurality of displacement ribs extending from the rigid wall, or from an outer edge of the tapered sealing surface, so as to surround the tapered sealing surface. The displacement ribs are spaced apart to mitigate against unwanted occlusion of the tapered sealing surface.
A flexible multi-chamber bag for storing and reconstituting parenteral nutrition solutions is disclosed. The flexible multichamber bag comprises a first peelably sealing wall and a second peelably sealing wall between the two polymer films extending from the top edge to the bottom edge and separating the first bag into a first chamber between the first peelably sealing wall and the second peelably sealing wall, a first space between the left edge and the first peelably sealing wall, a second space between the second peelably sealing wall and the right edge; a third peelably sealing wall extending from the left edge to the first peelably sealing wall to separate the first space to form a third chamber and a fourth chamber; and a fourth peelably sealing wall extending from the right edge to the second peelably sealing wall to separate the second space to form a second chamber and a fifth chamber.
An infusion pump includes a housing, a pumping mechanism, an accelerometer configured to detect at least one of pump motion and pump angular orientation, and a temperature control unit. The temperature control unit is configured to receive accelerometer data and determine a pump configuration based on the accelerometer data. The pump configuration may include a contact configuration or a non-contact configuration. The temperature control unit is also configured to establish a threshold housing temperature based on the determined pump configuration. Additionally, the temperature control unit is configured to modify at least one pump feature or function to maintain the housing below the threshold housing temperature.
A dialysis machine operable with a disposable set having at least one container, the dialysis machine including a pump actuator operable to pump dialysis fluid to and/or from the at least one container; a weigh plate positioned to support the at least one container; a plurality of operational load cells positioned to support the weigh plate; a linear actuator positioned to apply a force to the weigh plate; a calibration load cell positioned to measure the force applied by the linear actuator; and a control unit in operable communication with the operational load cells, the linear actuator and the calibration load cell, the control unit configured to cause the linear actuator to apply the force to the weigh plate, compare resulting outputs from the operational load cells and the calibration load cell, and determine a calibration factor from the comparison for offsetting future outputs from the operational load cells.
Provided is a system comprising a flexible container for intravenous administration which comprises a premix vasopressin pharmaceutical formulation, and uses thereof.
The invention relates to a flexible container/multi-chamber container with selective dissolved gas content for stabilizing at least one compound of a medical product having a selective gas requirement for remaining stable, comprising a solution comprising the at least one compound and a fil material from which the container is made that provides for high gas-barrier for the said gas. The at least one compound may be selenium in the form of Se(IV) and is preferably selected from the group consisting of sodium selenite, selenous acid and selenium dioxide. The selective gas may be oxygen, and the headspace of the oxygen maintains the solution to comprise dissolved oxygen (DO) at a level of 0.5 ppm to 8 ppm.
A61J 1/20 - Arrangements for transferring fluids, e.g. from vial to syringe
A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
87.
PORT ARRANGEMENT, A PURIFIED WATER PRODUCING APPARATUS COMPRISING THE PORT ARRANGEMENT AND A METHOD FOR PERFORMING PORT CLEANING OF A PURIFIED WATER PRODUCING APPARATUS
An apparatus including a casing, a fluid circuit enclosed in inside the casing, and a port arrangement is provided. The port arrangement includes a first port, a second port, and a door, and the port arrangement is positioned such that the door, a front end of the first port, and a front end of the second port are accessible from the outside of the apparatus. Further, the first port is arranged to receive a first connector, and the second port is arranged to receive a second connector.
Delivery devices, delivery systems, and related methods, for precise administration of hemostatic compositions are disclosed, which may include a trigger mechanism, a pusher, a valve, and a cannula. The pusher is configured to engage with the trigger mechanism, retain a first syringe, a least by coupling with a plunger of the first syringe. The valve is fluidly coupled to the first syringe. The valve is further configured to engage with a second syringe, in fluid communication with both the valve and the first syringe. The cannula extends distally from and is fluidly coupled to the valve. Activation of the trigger mechanism causes the pusher and the plunger of the first syringe to translate in a distal direction, to expel a composition out of the first syringe, through the valve, through the cannula, and out of a distal end of the cannula.
A medical fluid management assembly includes a pneumatic manifold, at least one valve, and a fluid manifold. The pneumatic manifold includes at least one pneumatic passageway that is pneumatically connected to the at least one valve. The fluid manifold includes at least one chamber comprising upper and lower fluid chambers separated by a flexible membrane. The fluid manifold also includes fluid tube sections and fluid pathways that fluidly couple the one or more upper and lower fluid chambers to the at least one valve and at least one of a purified water line, a liquid concentrate line, a to-extracorporeal circuit fresh dialysis fluid line, a drain line, or a from-extracorporeal circuit used dialysis fluid line.
The invention provides a sensor for measuring both impedance and ECG waveforms that is configured to be worn around a patient's neck. The sensor features 1) an ECG system that includes an analog ECG circuit, in electrical contact with at least two ECG electrodes, that generates an analog ECG waveform; and 2) an impedance system that includes an analog impedance circuit, in electrical contact with at least two (and typically four) impedance electrodes, that generates an analog impedance waveform. Also included in the neck-worn system are a digital processing system featuring a microprocessor, and an analog-to-digital converter. During a measurement, the digital processing system receives and processes the analog ECG and impedance waveforms to measure physiological information from the patient. Finally, a cable that drapes around the patient's neck connects the ECG system, impedance system, and digital processing system.
A cartridge assembly for a filling machine includes a plurality of containers. Each container includes a volume and a stem connected to the volume. A connection line grid is in fluid communication with each stem of the plurality of containers. The connection line grid includes a first row connected to one or more containers of the plurality of containers and a second row connected to one or more containers of the plurality of containers. A filter assembly is coupled to the connection line grid.
B65B 57/04 - Automatic control, checking, warning or safety devices responsive to absence, presence, abnormal feed, or misplacement of binding or wrapping material, containers, or packages and operating to control, or to stop, the feed of such material, containers, or packages
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
B65B 3/04 - Methods of, or means for, filling the material into the containers or receptacles
B65B 3/12 - Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material mechanically, e.g. by pistons or pumps
B65B 37/06 - Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged by pistons or pumps
B65B 39/00 - Nozzles, funnels or guides for introducing articles or materials into containers or wrappers
B65B 51/14 - Applying or generating heat or pressure or combinations thereof by reciprocating or oscillating members
B65B 51/22 - Applying or generating heat or pressure or combinations thereof by friction or ultrasonic or high-frequency electrical means
B65B 55/12 - Sterilising contents prior to, or during, packaging
B65B 61/06 - Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for severing webs, or for separating joined packages by cutting
B65B 65/00 - Details peculiar to packaging machines and not otherwise provided forArrangements of such details
A medical fluid control port assembly is disclosed. The medical fluid control port assembly eliminates contamination of a fluid path in peritoneal dialysis solution containers by incorporating ways to operate fluid flow without using a frangible. The disclosed fluid control port assembly is made up of an upper stem and a lower stem. The upper stem has a male threaded portion configured for mating to the lower stem having a female threaded portion. The upper stem has at least two snapfit ridges and the lower stem has at least one snapfit ridge. The snapfit ridges are provided to lock the fluid control port in a closed configuration to restrict fluid flow, or in an open configuration to initiate fluid flow. The control port is configured to allow a patient to use their fingers to rotate the upper stem and lower stem during dialysis therapy to easily control fluid flow.
A perforating connector assembly is disclosed. The perforating connector assembly includes a valve for sealing to a medical fluid container and a perforating connector comprising a perforator sealingly accepted by the valve. The perforator includes a spiked end and a lever comprising a tab. The perforating connector also comprises a shell extending around the perforator sealingly accepted by the valve. The shell includes at least a post-activation opening. The perforating connector further comprises a spring decompressed during post-activation to translate the perforator so that the medical fluid container is pierced open by the spiked end and the tab becomes located within the post-activation opening of the shell, thereby preventing the perforator from being translated further.
A wearable heads-up display (“HUD”) for a pharmacy workflow management system is disclosed herein. An example HUD includes smart-glasses that are communicatively coupled to a client device. The smart-glasses include at least one camera and/or barcode scanner to record information needed for the verification of a medication dose during medication formulation preparation. The smart-glasses include at least one microphone to record voice commands. Further, the smart-glasses include at least one embedded display screen that shows sequential steps of a preparation protocol for guiding a pharmacy technician to prepare a medication dose. An application on the client device and/or the smart-glasses is configured to recognize and use voice commands to provide navigation for the embedded display screen. The voice commands may also be used to provide data entry for medication dose preparation verification. Gestures may be detected by the camera and translated by the application into navigation or data entry commands.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G09B 19/00 - Teaching not covered by other main groups of this subclass
G10L 15/22 - Procedures used during a speech recognition process, e.g. man-machine dialog
A mobile dialysis therapy cart includes a top shelf and a fluid bag management compartment located beneath the top shelf. The fluid bag management compartment includes at least one heating device for heating a fluid bag. The mobile dialysis therapy cart also includes at least one temperature sensor located to sense a temperature associated with dialysis fluid located within the fluid bag. The mobile dialysis therapy cart further includes a control unit communicatively coupled to the at least one heating device and the at least one temperature sensor. The control unit is programmed to use an output from the at least one temperature sensor to operate the at least one heating device to heat the dialysis fluid within the fluid bag to a desired temperature.
A method is disclosed for evaluating a condition of an apparatus arranged to output a fluid through an outlet port and through at least one sterilizing grade filter of a line set fluidly connected to the outlet port. The method includes monitoring a flow rate correlated with a flow rate of the fluid flowing through the at least one sterilizing grade filter, monitoring a pressure correlated with a pressure of the fluid flowing to the at least one sterilizing grade filter, and evaluating a condition of the apparatus based on a relationship between the monitored flow rate and the monitored pressure.
A water purification apparatus capable of being cleaned at a point of care and methods for cleaning the water purification apparatus at the point of care are disclosed herein. The water purification apparatus and the methods provide an efficient use of a heater for heat disinfection the water purification apparatus. The water purification apparatus and the methods provide heat disinfection by recirculating heated fluid to further heat the fluid. Several different cleaning programs are provided that may be utilized for cleaning different parts of the water purification apparatus.
A flexible multi-chamber bag for storing and reconstituting parenteral nutrition solutions is disclosed. The flexible multi-chamber bag comprises two first peelably sealing walls between the two polymer films and separating the first bag into a first chamber, a second chamber and a third chamber, wherein the first chamber is between the second chamber and the third chamber; and at least one of the two first peelably sealing walls split into a second plurality of second peelably sealing walls and the second plurality of the second sealing walls sealed to the bottom edge to form a fourth chamber.
A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes DetailsAccessories therefor
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
B65B 3/02 - Machines characterised by the incorporation of means for making the containers or receptacles
New and improved container outlet valve closures are provided for medical solution containers. The closures are flexible and keep the solutions in their containers until acted upon. By applying a certain force on the closure, a pop-up valve is opened to permit flow of the medical solution from the container. The closures may be used with a variety of materials. Closure opening is easily activated and does create particle pollution for the medical solution. Closures for sidewall mounted and gondola style containers are provided.
A bag in a box therapy system may be provided by an item of manufacture, comprising: a box, containing: a first bag; a second bag; and a plurality of tubes and a tube connector; wherein the first bag comprises an internal reservoir and a first port, and contains a fluid disposed within the internal reservoir; and the plurality of tubes is configured provide one-way fluid communication from the internal reservoir to the tube connector via the first port, and configured provide one way fluid communication from the tube connector to the second bag.
