The invention relates to hemostatic compositions comprising ellagic acid-metal complex and uses thereof for activating the intrinsic pathway of blood coagulation. In particular, disclosed are hemostatic compositions comprised of ellagic acid complexed with nickel ions, the complex being dispersed or embedded within an absorbable polymeric matrix such as gelatin. Further disclosed are method for making the hemostatic compositions.
The invention relates to hemostatic compositions comprising ellagic acid-metal complex and uses thereof for activating the intrinsic pathway of blood coagulation. In particular, disclosed are hemostatic compositions comprised of ellagic acid complexed with nickel ions, the complex being dispersed or embedded within an absorbable polymeric matrix such as gelatin. Further disclosed are method for making the hemostatic compositions.
HSHS) that indicates a probability of a micro-organism expressing growth once exposed to a unit of sterilant; determine, based, at least in part, on the hypothesized sterilant resistance, an estimated number of samples that include a micro-organism expressing growth once exposed to the unit of sterilant; determine an observed number of samples that include a micro-organism expressing growth subsequent to exposure to the unit of sterilant; iteratively determine, based on one or more iterations, at least one first correction based on the observed number and the estimated number, and apply convergence criteria to determine whether to perform a next iteration; and determine the application condition of the sterilant, based on the first correction. Other aspects are also described and claimed.
G16H 40/00 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices
Various embodiments of the present invention are directed towards a single barrier folder to carry a suture and a needle therein. The single barrier folder comprises a plurality of openings configured to allow placement of a suture and form a suture winding and a first flap comprising a needle parking mechanism. The needle parking mechanism comprises a first portion, a notch, and a cutout. The cutout and the notch are configured to hold the needle and the first portion is foldable and configured to fold in locking engagement with the notch. The single barrier folder also comprises a second flap and a third flap on opposite sides of the plurality of openings and a slit configured to receive an end portion of a fourth flap to lock the single barrier folder. The present invention also provides method of placing and folding the flaps to pack needle and suture inside the single barrier folder.
A system may determine an application condition of sterilant to achieve a sterility assurance level (SAL) for an article. The system may determine a hypothesized sterilant resistance (ΘHS) that indicates a probability of a micro-organism expressing growth once exposed to a unit of sterilant; determine, based, at least in part, on the hypothesized sterilant resistance, an estimated number of samples that include a micro-organism expressing growth once exposed to the unit of sterilant; determine an observed number of samples that include a micro-organism expressing growth subsequent to exposure to the unit of sterilant; iteratively determine, based on one or more iterations, at least one first correction based on the observed number and the estimated number, and apply convergence criteria to determine whether to perform a next iteration; and determine the application condition of the sterilant, based on the first correction. Other aspects are also described and claimed.
A61L 2/28 - Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
6.
SYSTEMS, DEVICES AND METHODS FOR RECONSTITUTING THERAPEUTIC POWDERS, MIXING PRECURSOR SOLUTIONS, AND EXPRESSING SEALANTS FOR CONTROLLING BLEEDING AND SEALING FLUID AND AIR LEAKS
A sealant delivery system includes a syringe assembly having side-by-side syringes and a vial assembly having side-by-side vials. A first vial is aligned with a distal end of a first syringe and has a vial opening at the proximal end thereof that is closed by a first sealing membrane. A second vial is aligned with a distal end of a second syringe and has a second vial opening at the proximal end thereof that is closed by a second sealing membrane. The vial assembly includes a first piercing element moveable between a retracted position and an extended position for piercing the first sealing membrane to provide fluid communication between the first fluid chamber and the first vial, and a second piercing element moveable between a retracted position and an extended position for piercing the second sealing membrane to provide fluid communication between the second fluid chamber and the second vial.
Disclosed herein are flowable biocompatible sealant compositions in the form of a biodegradable cross-linked gel, comprised of an insoluble agent for preventing infection, and an agent for preventing ischemia, wherein the agent for preventing ischemia is embedded in polymeric microparticles. The composition is characterized in that it releases at least part of said agents in a sustained manner. Uses of the compositions in methods for treating a leakage from a gastrointestinal site are further disclosed.
Disclosed herein are flowable biocompatible sealant compositions in the form of a biodegradable cross-linked gel, comprised of an insoluble agent for preventing infection, and an agent for preventing ischemia, wherein the agent for preventing ischemia is embedded in polymeric microparticles. The composition is characterized in that it releases at least part of said agents in a sustained manner. Uses of the compositions in methods for treating a leakage from a gastrointestinal site are further disclosed.
The present invention is directed to a sealant patch for use on or over sensitive tissue, comprising: a flat, flexible, bioresorbable substrate coated by a moisture-activated adhesive on one side thereof, wherein said adhesive is at least partially inactivated in a first portion of said patch, but remains active in peripheral areas surrounding the first portion. The adherence of the first portion to the tissue is weaker versus adherence in the peripheral areas. The adhesive in the first portion is fully or partially inactivated or pre-reacted prior to application of the sealant patch to the tissue.
A61F 15/00 - Auxiliary appliances for wound dressingsDispensing containers for dressings or bandages
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
The present invention is directed to a sealant patch for use on or over sensitive tissue, comprising: a flat, flexible, bioresorbable substrate coated by a moisture-activated adhesive on one side thereof, wherein said adhesive is at least partially inactivated in a first portion of said patch, but remains active in peripheral areas surrounding the first portion. The adherence of the first portion to the tissue is weaker versus adherence in the peripheral areas. The adhesive in the first portion is fully or partially inactivated or pre-reacted prior to application of the sealant patch to the tissue.
The present invention is directed to methods for processing absorbable, slow-to-crystallize poly(p-dioxanone) ground resin and its fines utilizing a twin-screw extruder apparatus to produce uniform pellets. Advantageously, the ground resin materials resulting from solid-state polymerization do not undergo processing, such as sieving, to remove fines from the feedstock for an extrusion and pelletizing system that has been configured with an inverted temperature profile along the extrusion barrel. The resulting PDS pellets have improved resin uniformity and greater polymer yield for improved operational efficiencies and production of extruded filaments.
The present invention is directed to hemostatic and/or tissue adhesive formulations comprising crosslinked polysaccharide particles that have been oxidized to generate aldehyde- and carboxylic functional moieties therein, and wherein said formulations further contain a buffer that maintains a slightly alkaline environment. These formulations can be applied onto tissue in the form of a powder, paste or patch to effect hemostasis or sealing.
The present invention is directed to hemostatic and/or tissue adhesive formulations comprising crosslinked polysaccharide particles that have been oxidized to generate aldehyde- and carboxylic functional moieties therein, and wherein said formulations further contain a buffer that maintains a slightly alkaline environment. These formulations can be applied onto tissue in the form of a powder, paste or patch to effect hemostasis or sealing.
The present invention is directed to an absorbable hemostatic nonwoven patch that utilizes a biocompatible substrate comprised of melt-blown microfibers as webbed sheets that are layered and bonded/entangled in descending density and ascending porosity; with the substrate having a high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ability for laparoscopic use or trocar deployment, ultimately for functional use as a highly effective hemostat in addressing problematic bleeding during both open and minimally invasive surgical procedures.
A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
15.
COMBINED HEMOSTATIC POWDER AND LIQUID DELIVERY DEVICES FOR CONTROLLING BLEEDING AND SEALING TISSUE AT SURGICAL SITES
A combined powder and liquid delivery device includes a housing having a powder chamber and a liquid chamber. The device includes an applicator tip having a powder delivery channel extending between a proximal end and a distal end of the applicator tip that is in fluid communication with the powder chamber, and a liquid delivery channel that extends from the proximal to the distal end of the applicator tip that is in fluid communication with the liquid chamber. The delivery device includes a powder inlet port in fluid communication with the powder chamber, and a liquid inlet port in fluid communication with the liquid chamber. A powder delivery system is in fluid communication with the powder inlet port, the powder chamber, and the powder delivery channel. A liquid delivery system is in fluid communication with the liquid inlet port, the liquid chamber, and the liquid delivery channel.
Disclosed herein are powdered compositions comprised of fibrinogen, thrombin, glycerol-water solution, and optionally oxidized cellulose (OC), wherein the glycerol is present at a concentration ranging from about 0.7% to about 6%, by weight; and wherein the OC is present at a concentration below about 9%, by weight, or is absent. Methods of making the compositions, and uses of the compositions in methods for treating a bleeding tissue, and for sealing leaks in tissues are further disclosed.
A healthcare system accommodates spasmodic clinical workflows for populating a records database associated with a surgical platform or other digital healthcare platform. An interoperability engine receives data streams including events from various electronic health records systems that provide data events according to varying format, order, and timing dependent on their corresponding clinical workflows. The interoperability engine maps indeterminate events to expected events associated with a clinical workflow based on a clinical workflow management file, an industry standard model, a general parsing model, or a combination thereof. The interoperability engine may furthermore detect non-compliance of received events and may generate feedback indicative of a compliance assessment.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
Disclosed is a sealant, and techniques for making and using the sealant. The sealant may include three components that, when combined, produce the sealant: an electrophilic component, a nucleophilic component, and a doping component. The electrophilic component may include a first electrophilic material having a first functionality of a first reactive group. The nucleophilic component may include a first nucleophilic material having a second functionality of a second reactive group. The doping component may include a second electrophilic material having a third functionality of the first reactive group greater than the first functionality and/or a second nucleophilic material having a fourth functionality of the second reactive group greater than the second functionality. The doping component may be present in an amount sufficient to provide a 2-20% molar contribution of the first reactive group and/or the second reactive group in the sealant.
Disclosed is a sealant, and techniques for making and using the sealant. The sealant may include three components that, when combined, produce the sealant: an electrophilic component, a nucleophilic component, and a doping component. The electrophilic component may include a first electrophilic material having a first functionality of a first reactive group. The nucleophilic component may include a first nucleophilic material having a second functionality of a second reactive group. The doping component may include a second electrophilic material having a third functionality of the first reactive group greater than the first functionality and/or a second nucleophilic material having a fourth functionality of the second reactive group greater than the second functionality. The doping component may be present in an amount sufficient to provide a 2-20% molar contribution of the first reactive group and/or the second reactive group in the sealant.
Methods and systems for using a biocompatible and flexible hemostatic sheet comprising a fibrous carrier structure, and reactive electrophilic groups capable of reacting with amine groups in tissue and blood, the hemostatic sheet delivered through a trocar for restoring hemostasis to a tissue at a bleeding site of an organ during minimally invasive treatment of hemorrhage.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/42 - Use of materials characterised by their function or physical properties
22.
SYSTEM AND METHODS FOR USING TISSUE-ADHESIVE POROUS HEMOSTATIC PRODUCTS WITH SEVERE SURFACE AND CAVITY BLEEDING
Methods and systems for using a biocompatible and flexible hemostatic sheet comprising a fibrous carrier structure, and reactive electrophilic groups capable of reacting with amine groups in tissue and blood, the hemostatic sheet delivered to the tissue at the bleeding site of an organ to restore hemostasis during an open surgery procedure.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/42 - Use of materials characterised by their function or physical properties
Provided herein are methods for preparation of fibrinogen by purifying fibrinogen from a plasma fraction being depleted of prothrombin. The plasma fraction depleted of prothrombin is obtained, for example, by adding an anticoagulant to a source of blood; separating plasma from the source of blood, and extracting the prothrombin from the plasma, thereby obtaining a prothrombin depleted plasma fraction and a plasma fraction comprised of prothrombin.
The present invention is directed to compressed hemostatic tablets or forms comprising a fibrous non-woven oxidized cellulose (OC or ORC) multilayer material compressed into a form stable tablet, further comprising calcium salt, with the tablets rapidly expandable on contact with blood or blood plasma. The compressed forms may further comprise a multi-arm PEG-SG and are dimensionally, preferably with regard to length and width, stable for at least 48 hours after compression. In some embodiments, the compressed forms will expand upon contact with blood from 1.5 to 5 times of tablet length in 5 seconds; from 2 to 6 times of tablet length in 20 seconds; and from 3 to 6 times of tablet length in 5 minutes. The compressed forms are effective in hemostasis in heparinized blood.
The present invention is directed to compressed hemostatic tablets or forms comprising a fibrous non-woven oxidized cellulose (OC or ORC) multilayer material compressed into a form stable tablet, further comprising calcium salt, with the tablets rapidly expandable on contact with blood or blood plasma. The compressed forms may further comprise a multi-arm PEG-SG and are dimensionally, preferably with regard to length and width, stable for at least 48 hours after compression. In some embodiments, the compressed forms will expand upon contact with blood from 1.5 to 5 times of tablet length in 5 seconds; from 2 to 6 times of tablet length in 20 seconds; and from 3 to 6 times of tablet length in 5 minutes. The compressed forms are effective in hemostasis in heparinized blood.
The disclosure encompasses systems, compositions, and methods for use in vivo, including for reinforcement of soft tissue in an individual. The systems, compositions, and methods may utilize three-dimensionally printed scaffolds comprising at least a polymer scaffold and an extracellular matrix component(s), including comprised on the scaffold. The polymer scaffold may comprise particular unit cell structures of a specific design and patterns of alternating configurations of the unit cell structures.
Provided herein are hydrogel-hydrocolloid sealant compositions for use as soft-tissue sealants. The compositions can include a cross-linkable electrophilic component; a cross-linkable nucleophilic component; a swellable filler material including gelatin; and, a buffer having a pH in the range of about 9.0 to about 10.0. The compositions can have a first fluid state and a second crosslinked state, and in the crosslinked state, the electrophilic and nucleophilic components can crosslink to form a crosslinked hydrogel network where the swellable filler material including gelatin is disposed within the crosslinked network. Also provided are systems and methods of manufacturing the sealant compositions as well as methods of repairing soft tissue defects including applying the sealant compositions disclosed herein.
Provided herein are hydrogel-hydrocolloid sealant compositions for use as soft-tissue sealants. The compositions can include a cross-linkable electrophilic component; a cross-linkable nucleophilic component; a swellable filler material including gelatin; and, a buffer having a pH in the range of about 9.0 to about 10.0. The compositions can have a first fluid state and a second crosslinked state, and in the crosslinked state, the electrophilic and nucleophilic components can crosslink to form a crosslinked hydrogel network where the swellable filler material including gelatin is disposed within the crosslinked network. Also provided are systems and methods of manufacturing the sealant compositions as well as methods of repairing soft tissue defects including applying the sealant compositions disclosed herein.
The disclosure encompasses systems, compositions, and methods for use in vivo, including for reinforcement of soft tissue in an individual. The systems, compositions, and methods may utilize three-dimensionally printed scaffolds comprising at least a polymer scaffold and an extracellular matrix component(s), including comprised on the scaffold. The polymer scaffold may comprise particular unit cell structures of a specific design and patterns of alternating configurations of the unit cell structures.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
The invention relates to biodegradable bilayer sealants for tissue closure. The sealants of the invention are composed of two layers with different compliances. The layer in immediate contact with the tissue has high compliance. The second layer located immediately above the first sealant layer has low compliance, i.e. the sealant is much stiffer. The burst pressure of the bilayer sealants is enhanced relative to either a single layer elastic sealant or a single layer stiff sealant. The improved sealant compositions herein provide a water-tight seal, can access hard to reach tears, be applied in a dry or wet environment, are low-swelling, and can repair a range of incision or tear sizes. The bilayer sealants are particularly useful for sutureless dural closure or as adjuncts to sutured dural closure. Also provided herein are methods of preparing and using the biodegradable sealant compositions.
The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.
The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.
The invention relates to biodegradable bilayer sealants for tissue closure. The sealants of the invention are composed of two layers with different compliances. The layer in immediate contact with the tissue has high compliance. The second layer located immediately above the first sealant layer has low compliance, i.e. the sealant is much stiffer. The burst pressure of the bilayer sealants is enhanced relative to either a single layer elastic sealant or a single layer stiff sealant. The improved sealant compositions herein provide a water-tight seal, can access hard to reach tears, be applied in a dry or wet environment, are low-swelling, and can repair a range of incision or tear sizes. The bilayer sealants are particularly useful for sutureless dural closure or as adjuncts to sutured dural closure. Also provided herein are methods of preparing and using the biodegradable sealant compositions.
A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials
A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
35.
Methods and Devices for Changing the Flow Rates of PH Modifying Fluids for Controlling Cross-Linking Rates of Reactive Components of Biocompatible Sealing Compositions
A method of making a biocompatible composition for sealing tissue includes mixing a first fluid having a first reactive component (e.g., an electrophile) and a second fluid having a second reactive component (e.g., a nucleophile) to form a mixture and expressing the mixture. During expression, a pH modifying fluid (e.g., NaOH) is added to the mixture at a rate that changes. In one embodiment, a higher ratio of the pH modifying fluid is added to the mixture during a first expressing stage and a lower ratio of said pH modifying fluid is added to the mixture during a second expressing stage. During the first expressing stage, a mixing ratio of the pH modifying fluid, the first fluid and the second fluid is 0.7-1.4:1:1. During the second expressing stage, the mixing ratio of the pH modifying fluid, the first fluid and the second fluid is 0.12-0.24:1:1.
The present invention is directed to coated medical devices, such as implantable and coatable devices, such as sutures, with expanded antibacterial properties, handling, knot slide and in-situ performance and processes for their manufacture and use.
The present disclosure relates to a method for preparing a haemostatic composition comprising thrombin, the method comprising the step of reconstituting a dry thrombin directly in a paste, such as a paste comprising a biocompatible polymer. The haemostatic composition comprising thrombin may be prepared from a dry thrombin composition and a paste in a single step operation and be used for treatment of a wound.
A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
38.
COMPOSITE SUTURE NEEDLES HAVING ELASTICALLY DEFORMABLE SECTIONS
A composite suture needle configured for passing through a smaller cannula used in minimally invasive surgery includes a curved elongated body made of stainless steel. The curved elongated body has a proximal end and a distal end with a pointed tip. The composite suture needle includes a sheath overlying the curved elongated body. The sheath is curved for conforming to the shape of the curved elongated body. The sheath is made of a material that is more elastic than the curved elongated body. The pointed tip of the curved elongated body extends distally beyond the distal end of the sheath. The curved elongated body is made of stainless steel and the sheath is made of a material, such as nitinol, that is more elastic than the elongated body.
A61B 17/06 - NeedlesHolders or packages for needles or suture materials
A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
The present disclosure is also directed to a system for managing inventory within a dispenser that is configured to maintain a known inventory and is configured to transmit inventory values from the dispenser so that other users can review the inventory values. Also, the dispenser is configured to be accessed by users locally and through an internet connection so that the inventory can be reviewed.
B65G 1/137 - Storage devices mechanical with arrangements or automatic control means for selecting which articles are to be removed
A61B 90/90 - Identification means for patients or instruments, e.g. tags
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G06K 7/10 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation
G06K 7/14 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
G06Q 10/0875 - Itemisation or classification of parts, supplies or services, e.g. bill of materials
G06Q 30/014 - Providing recall services for goods or products
Provided herein are compositions, systems and surgical methods for treating expandable soft tissue utilizing a reactive liquid hydrogel sealant mixture including a cross-linkable electrophilic compound, a nucleophilic compound, and an amphiphilic poly(alkyl)ene glycol block polymer in an amount of 20% (w/v) or less of the sealant composition. The composition can optionally include a viscosifier, in an amount of 0.1% to 1.0% (w/v) of the sealant composition.
Provided herein are compositions, systems and surgical methods for treating expandable soft tissue utilizing a reactive liquid hydrogel sealant mixture including a cross-linkable electrophilic compound, a nucleophilic compound, and an amphiphilic poly(akyl)ene glycol block polymer in an amount of 20% (w/v) or less of the sealant composition. The composition can optionally include a viscosifier, in an amount of 0.1% to 1.0% (w/v) of the sealant composition.
Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.
A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
A61L 15/26 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bondsDerivatives thereof
Systems, computer-readable instructions, and methods for dispensing and tracking medical products in various medical locations are disclosed. For example, the system may include a server which receives one or more requests for types of medical products from one or more client devices, determines whether the requested types and quantities are available in a dispenser and issues an instruction to the dispenser to automatically dispense the requested medical products and quantities. The server may receive confirmation after the types of medical products are dispensed from the dispenser and update a database. The server may receive unused and used medical product information from a client device and reconcile with restocked medical product information from the dispenser. Available types of medical products and quantities, usage reports and recommendations may be viewed via a Platform by one or more client devices. The dispenser may receive requests directly from a client device for medical products.
A packaged antimicrobial suture. The packaged antimicrobial suture includes an inner package having a source of antimicrobial agent, the source of antimicrobial agent comprising a plurality of patches, each patch having a pair of antimicrobial material reservoirs; at least one suture positioned within the inner package, the at least one suture comprising one or more surfaces; and an outer package having an inner surface, the outer package having the inner package positioned within; wherein the at least one suture, the inner package and the inner surface of the outer package are subjected to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the at least one suture and the inner package, thereby substantially inhibiting bacterial colonization on the at least one suture and the inner package. A method of making a packaged antimicrobial suture is also provided.
A device comprising may include a processor. The processor may be configured to receive data indicative of air exchange between a surgical ventilator and a patient. The processor may be configured to receive data indicative of air leaving the patient via a chest tube. With regard to this data, the processor may be configured to sample one or more sensors at a rate to capture an identifiable signal associated with prolonged-air-leak-occurrence for a population. And this signal may be predictive of the likelihood of a prolonged air leak developing in the patient. For example, a machine learning model may be trained using the data indicative of ventilator-patient air exchange, chest tube air loss, and prolonged-air-leak-occurrence for a population.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present invention is directed to coated medical devices, such as implantable and coatable devices, such as sutures, with expanded antibacterial properties, handling, knot slide and in-situ performance and processes for their manufacture and use.
A device may include a sensor and a processor. The sensor may measure air leaving a patient via a chest tube. The processor may be configured to sample data from the sensor. For example, the processor may be configured to sample data from the sensor at a rate suitable to capture a signal associated with prolonged-air-leak-occurrence for a population. For example, the rate may be suitable to capture variations in the measure air within a breath cycle. For example, rate may be suitable to capture a number and magnitude of peaks in the signal. Based on the signal, the processor may output information indicative of prolonged-air-leak-likelihood for the patient.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
A device may include a processor. The processor may be configured to receive data during a surgery. The processor may receive data representative of a patient's intraoperative air exchange. The data may represent air exchange for a patient's breath cycle. For example, data may include any of ventilator inlet flow rate, ventilator inlet pressure, ventilator output pressure, chest tube flow rate, or chest tube pressure. The processor may also receive data representative of a surgical parameter other than one related to air exchange. For example, this data may include any of patient medical record data, intraoperative reporting data, surgical procedure data, or the like. The processor may be configured to receive an updated machine learning model from a cloud resource. And the processor may output, during the surgery, information indicative of prolonged-air-leak-likelihood based on data.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61M 16/10 - Preparation of respiratory gases or vapours
49.
VARIABLE LENGTH TELESCOPING APPLICATION TIPS FOR FLOWABLE HEMOSTATS AND SEALANTS APPLICATION
The present invention is directed to a variable length applicator system for delivery of at least one medically useful liquid, comprising an elongated, telescopically extendable, variable length cannula having a liquid pump containing said liquid connected to said cannula at a proximal end, and a spray nozzle mounted on said cannula at a distal end; a coiled and extendable tubular conduit connected to and in fluid communication with, both said liquid pump and said spray nozzle; wherein an axial extension of said cannula is configured to cause a matching axial extension of said coiled tubular conduit.
The present invention is directed to a variable length applicator system for delivery of at least one medically useful liquid, comprising an elongated, telescopically extendable, variable length cannula having a liquid pump containing said liquid connected to said cannula at a proximal end, and a spray nozzle mounted on said cannula at a distal end; a coiled and extendable tubular conduit connected to and in fluid communication with, both said liquid pump and said spray nozzle; wherein an axial extension of said cannula is configured to cause a matching axial extension of said coiled tubular conduit.
A61B 17/00 - Surgical instruments, devices or methods
51.
Systems, devices and methods for reconstituting therapeutic powders, mixing precursor solutions, and expressing sealants for controlling bleeding and sealing fluid and air leaks
A sealant delivery system includes a syringe assembly having side-by-side syringes and a vial assembly having side-by-side vials. A first vial is aligned with a distal end of a first syringe and has a vial opening at the proximal end thereof that is closed by a first sealing membrane. A second vial is aligned with a distal end of a second syringe and has a second vial opening at the proximal end thereof that is closed by a second sealing membrane. The vial assembly includes a first piercing element moveable between a retracted position and an extended position for piercing the first sealing membrane to provide fluid communication between the first fluid chamber and the first vial, and a second piercing element moveable between a retracted position and an extended position for piercing the second sealing membrane to provide fluid communication between the second fluid chamber and the second vial.
A mixing and spraying assembly for a tissue sealant includes a mixing assembly, a spray tip assembly, and a malleable section having a proximal end connected with the mixing assembly and a distal end connected with the spray tip assembly for enabling the spray tip assembly to be angulated relative to the mixing assembly. The malleable section includes a flexible shaft having a length, a malleable wire conduit that extends along the length of the flexible shaft, and a malleable wire disposed in the malleable wire conduit. The malleable wire is longer than the flexible shaft and has a proximal end that is connected to the mixing assembly and a distal end that is connected to the spray tip assembly. First and second fluids are mixed within the mixing assembly to form a tissue sealant that is delivered through the malleable section for being expressed from the spray tip assembly.
A61B 17/00 - Surgical instruments, devices or methods
53.
SYSTEMS, DEVICES AND METHODS FOR RECONSTITUTING THERAPEUTIC POWDERS, MIXING PRECURSOR SOLUTIONS, AND EXPRESSING SEALANTS FOR CONTROLLING BLEEDING AND SEALING FLUID AND AIR LEAKS
A sealant delivery system includes a syringe assembly having side-by-side syringes and a vial assembly having side-by-side vials. A first vial is aligned with a distal end of a first syringe and has a vial opening at the proximal end thereof that is closed by a first sealing membrane. A second vial is aligned with a distal end of a second syringe and has a second vial opening at the proximal end thereof that is closed by a second sealing membrane. The vial assembly includes a first piercing element moveable between a retracted position and an extended position for piercing the first sealing membrane to provide fluid communication between the first fluid chamber and the first vial, and a second piercing element moveable between a retracted position and an extended position for piercing the second sealing membrane to provide fluid communication between the second fluid chamber and the second vial.
A mixing and spraying assembly for a tissue sealant includes a mixing assembly, a spray tip assembly, and a malleable section having a proximal end connected with the mixing assembly and a distal end connected with the spray tip assembly for enabling the spray tip assembly to be angulated relative to the mixing assembly. The malleable section includes a flexible shaft having a length, a malleable wire conduit that extends along the length of the flexible shaft, and a malleable wire disposed in the malleable wire conduit. The malleable wire is longer than the flexible shaft and has a proximal end that is connected to the mixing assembly and a distal end that is connected to the spray tip assembly. First and second fluids are mixed within the mixing assembly to form a tissue sealant that is delivered through the malleable section for being expressed from the spray tip assembly.
An assembly includes an insertion device and a suture delivery device. The insertion device includes a longitudinal guide member extending from a proximal end to a distal tip. The tip includes an abutting structure movable between insertion and open positions. The structure is sized and shaped to contact tissue surrounding the tissue opening into which the insertion device has been inserted to maintain a desired position of the insertion device within the opening. The delivery device includes a body and a tube. The tube extends along a curved path configured so that, as the tube is rotated about the member, the tube penetrates tissue surrounding the opening into which the member has been inserted. A distal extension of the tube is configured so that, when the tube has been advanced distally to a distal-most position on the member, a distal end of the tube is proximal of the structure.
A wound closure device and a method of its use are disclosed. The wound closure device comprises a wound closure strip, the wound closure strip comprising a wound-facing side and a top side, the wound-facing side comprises an adhesive applied over at least a portion of the wound facing side of the wound closure strip and a non-symmetric, two-part release liner assembly detachably adhered to the adhesive, the release liner assembly comprising a first section and a second section with the second section comprising a wound closure strip-free portion forming a tab. In an alternate embodiment, the device is multi-segmented and the wound closure strip may be coextensive with the release liner assembly.
A61F 13/0246 - Adhesive bandages or dressings characterised by the skin-adhering layer
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
An image of a zone of inhibition (ZOI) plate is received. The image is processed to detect sutures within the image of the ZOI plate using computer vision, detect a contour of a ZOI within the image of the ZOI plate using computer vision, generate an overlay based on smoothening the contour of the ZOI and perform one or measurements on the image of the ZOI plate, wherein each of the one or more measurements comprises a distance between the sutures and the overlay.
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
Various embodiments of the present invention are directed towards a single barrier folder to carry a suture and a needle therein. The single barrier folder comprises a plurality of openings configured to allow placement of a suture and form a suture winding and a first flap comprising a needle parking mechanism. The needle parking mechanism comprises a first portion, a notch, and a cutout. The cutout and the notch are configured to hold the needle and the first portion is foldable and configured to fold in locking engagement with the notch. The single barrier folder also comprises a second flap and a third flap on opposite sides of the plurality of openings and a slit configured to receive an end portion of a fourth flap to lock the single barrier folder. The present invention also provides method of placing and folding the flaps to pack needle and suture inside the single barrier folder.
Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability and are readily applied in coating processes a low temperatures that do not deform the device. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
B05B 7/16 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating the material to be sprayed
B05B 12/08 - Arrangements for controlling deliveryArrangements for controlling the spray area responsive to condition of liquid or other fluent material discharged, of ambient medium or of target
B05B 15/00 - Details of spraying plant or spraying apparatus not otherwise provided forAccessories
B05B 17/06 - Apparatus for spraying or atomising liquids or other fluent materials, not covered by any other group of this subclass operating with special methods using ultrasonic vibrations
B05D 1/02 - Processes for applying liquids or other fluent materials performed by spraying
B05D 3/04 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides
A sealant delivery device includes a housing, a matrix container connected with a distal end of the housing and being moveable between closed and opened positions, and a matrix, such as a hemostatic substrate, disposed within the matrix container. The sealant delivery device includes a sealant dispensing system in fluid communication with the matrix container that is configured for dispensing a sealant onto the matrix disposed within the matrix container. An actuator is coupled with the sealant dispensing system and the matrix container. The actuator is engageable for opening the matrix container for exposing the matrix and expressing the sealant onto the matrix. A component of the matrix container may be used to press the matrix and sealant expressed onto the matrix against target tissue to control bleeding of the target tissue.
A61B 50/30 - Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
A61B 17/00 - Surgical instruments, devices or methods
A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
Disclosed is a powdered composition comprised of: (i) thrombin, (ii) total protein in an amount of less than 75%, by weight, (iii) albumin in an amount of more than 5% by weight and iv) a non-acidic amino acid, the composition being substantially free of carbohydrates. A Method for preparing thrombin powders is also disclosed herein.
The invention relates to compositions comprised of albumin and clottable proteins including fibrinogen and to use thereof e.g., for treating bleeding. In particular, the compositions are comprised of albumin and one or more clottable proteins, wherein the albumin and the one or more clottable proteins are present at a total concentration of at least 90% by total protein weight, wherein the clottable protein fibronectin is present at an amount of less than about 0.5% by total protein weight or is absent, and wherein the weight ratio of the albumin to the clottable protein fibrinogen is at least 1:15, respectively.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/32 - Proteins, polypeptidesDegradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
A61L 15/42 - Use of materials characterised by their function or physical properties
A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials
The invention relates to compositions comprised of albumin and clottable proteins including fibrinogen and to use thereof e.g., for treating bleeding. In particular, the compositions are comprised of albumin and one or more clottable proteins, wherein the albumin and the one or more clottable proteins are present at a total concentration of at least 90% by total protein weight, wherein the clottable protein fibronectin is present at an amount of less than about 0.5% by total protein weight or is absent, and wherein the weight ratio of the albumin to the clottable protein fibrinogen is at least 1:15, respectively.
A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/42 - Use of materials characterised by their function or physical properties
66.
Systems, devices and methods for delivering sealants to target tissue for controlling bleeding of the target tissue
A sealant delivery device includes a housing, a matrix container connected with a distal end of the housing and being moveable between closed and opened positions, and a matrix, such as a hemostatic substrate, disposed within the matrix container. The sealant delivery device includes a sealant dispensing system in fluid communication with the matrix container that is configured for dispensing a sealant onto the matrix disposed within the matrix container. An actuator is coupled with the sealant dispensing system and the matrix container. The actuator is engageable for opening the matrix container for exposing the matrix and expressing the sealant onto the matrix. A component of the matrix container may be used to press the matrix and sealant expressed onto the matrix against target tissue to control bleeding of the target tissue.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 17/00 - Surgical instruments, devices or methods
67.
Combined storage and dispensing device for medical product
An elastic suture needle for passing through a smaller cannula used in minimally invasive surgery includes an elongated body having a proximal end, a distal end, a length extending from the proximal end to the distal end, a top surface extending along the length of the elongated body, and a bottom surface extending along the length of the elongated body. The elongated body has dimensions that are calculated using the equation T/LN < (2*σ)/(πE), where T is the thickness of the elongated body, LN is the length of the neutral axis of the elongated body, σ is the yield strength of the elongated body, and E is the Young’s modulus of the elongated body. The elongated body is made of stainless steels such as martensitic stainless steels, austenitic stainless steels, martensitic-aged (mar-aged) stainless steels, and stainless steels sold under the registered trademark ETHALLOY® Needle Alloy.
A61B 17/06 - NeedlesHolders or packages for needles or suture materials
A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
69.
Sutures with Coatings for Detecting and Reporting Tissue Infection
The present invention is directed to an implantable medical device, comprising: a device body, with at least a portion of said body coated by a sensing coating that comprises an echogenic material or a radiopaque material, or combinations thereof, said sensing coating configured to dissolve or swell in presence of at least one infection biomarker; wherein a portion of said sensing coating is covered by a protective film, forming a protected portion, said protected portion configured not to dissolve or swell in presence of said biomarker and methods of detecting presence of biomarkers in the vicinity of an implanted medical device.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
The present invention provides a tissue sealing plug comprising a substrate comprising foamed gelatin impregnated with polyethylene glycol that is liquid at room temperature, wherein the weight ratio of polyethylene glycol to foamed gelatin in the substrate is about 4:1 to about 6.8:1 and the substrate is substantially free of air, along with methods of using the plug for closing tissue punctures in the lung.
The present invention is directed to an implantable medical device, comprising: a device body, with at least a portion of said body coated by a sensing coating that comprises an echogenic material or a radiopaque material, or combinations thereof, said sensing coating configured to dissolve or swell in presence of at least one infection biomarker; wherein a portion of said sensing coating is covered by a protective film, forming a protected portion, said protected portion configured not to dissolve or swell in presence of said biomarker and methods of detecting presence of biomarkers in the vicinity of an implanted medical device.
A61L 17/14 - Post-treatment to improve physical properties
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/06 - NeedlesHolders or packages for needles or suture materials
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
The present invention provides a tissue sealing plug comprising a substrate comprising foamed gelatin impregnated with polyethylene glycol that is liquid at room temperature, wherein the weight ratio of polyethylene glycol to foamed gelatin in the substrate is about 4:1 to about 6.8:1 and the substrate is substantially free of air, along with methods of using the plug for closing tissue punctures in the lung.
A system for delivering a flowable, therapeutic composition, such as a flowable hemostat, biologics, or a medicine paste, includes a cannula having a proximal end with a proximal opening, a distal end with a distal opening, and an elongated lumen extending from the proximal end to the distal end. The flowable, therapeutic composition fills the elongated lumen of the cannula, and a piston is disposed within the elongated lumen for sealing the proximal end of the cannula. An end cap is secured to the distal end of the cannula. A pump assembly includes a fluid and is coupled with the proximal end of the cannula. After the end cap, is removed, the pump assembly is operable to pump the fluid for directing the fluid to flow through the proximal opening of the cannula to force the piston to slide toward the distal end of the cannula to express the flowable, therapeutic composition from the distal end of the cannula.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
The present invention provides a kit for preparing a composition for sealing a lung tract, comprising: (a) a first component comprising: (i) a fibrinogen solution, and (ii) prewet gelatin particles in an aqueous solution; and (b) a second component comprising: (i) a thrombin solution, and (ii) a dry gelatin powder; wherein the first and second components are stored separately and configured for mixing together to form a composition that is flowable and cross-linkable. The composition may be used to seal tissue tracts such as lung tissue tracts.
The present invention provides a kit for preparing a composition for sealing a lung tract, comprising: (a) a first component comprising: (i) a fibrinogen solution, and (ii) prewet gelatin particles in an aqueous solution; and (b) a second component comprising: (i) a thrombin solution, and (ii) a dry gelatin powder; wherein the first and second components are stored separately and configured for mixing together to form a composition that is flowable and cross-linkable. The composition may be used to seal tissue tracts such as lung tissue tracts.
A combined powder and liquid delivery device includes a housing having a powder chamber and a liquid chamber. The device includes an applicator tip having a powder delivery channel extending between a proximal end and a distal end of the applicator tip that is in fluid communication with the powder chamber, and a liquid delivery channel that extends from the proximal to the distal end of the applicator tip that is in fluid communication with the liquid chamber. The delivery device includes a powder inlet port in fluid communication with the powder chamber, and a liquid inlet port in fluid communication with the liquid chamber. A powder delivery system is in fluid communication with the powder inlet port, the powder chamber, and the powder delivery channel. A liquid delivery system is in fluid communication with the liquid inlet port, the liquid chamber, and the liquid delivery channel.
The present invention relates to a suturing system, comprising: an elongated flexible suture having a connecting end attached to a needle and an opposing free end, said suture co-packaged with a pierceable container containing a medicant solution. The invention further relates to a suturing system, comprising: an elongated flexible suture having a connecting end attached to a needle and an opposing free end, said suture co-packaged with a wicking medicant transfer sponge and a frangible container containing a liquid. In some embodiments, the invention relates to a suturing system, comprising: an elongated flexible suture having a connecting end attached to a needle and an opposing free end, said suture co-packaged with a medicant transfer sponge, said system further comprising a medicant dispenser container with a liquid.
The present invention relates to a suturing system, comprising: an elongated flexible suture having a connecting end attached to a needle and an opposing free end, said suture co-packaged with a pierceable container containing a medicant solution. The invention further relates to a suturing system, comprising: an elongated flexible suture having a connecting end attached to a needle and an opposing free end, said suture co-packaged with a wicking medicant transfer sponge and a frangible container containing a liquid. In some embodiments, the invention relates to a suturing system, comprising: an elongated flexible suture having a connecting end attached to a needle and an opposing free end, said suture co-packaged with a medicant transfer sponge, said system further comprising a medicant dispenser container with a liquid.
A method of making a catheter includes obtaining a hollow tube having a proximal section, a distal section, an elongated conduit, and one or more fluid openings formed in the distal section of the hollow tube that are in fluid communication with the elongated lumen. The method includes inserting a mandrel within the elongated lumen, positioning a first visible marker over an outer surface of the hollow tube at a junction of the proximal and distal sections of the hollow tube, and placing a sacrificial material over the first visible marker to completely cover the first visible marker. Heat is applied for shrinking the sacrificial material, which, in turn, compresses the first visible marker against the outer surface of the hollow tube, and for least partially melting the first visible marker for fusing the first visible marker to the outer surface of the hollow tube.
A catheter for delivering fluids includes a hollow tube having a proximal section, a distal section, and an elongated lumen that extends through the proximal and distal sections of the hollow tube. One or more fluid openings are formed in the distal section of the hollow tube, which are in fluid communication with the elongated lumen of the hollow tube. A visible marker collar is secured to an outer surface of the hollow tube and is located at a junction of the proximal and distal sections of the hollow tube. A visible marker filament is disposed within the elongated lumen of the hollow tube and extends between the junction of the proximal and distal sections of the hollow tube and a distal end of the hollow tube. The visible markers are used to identify a soaker region of the catheter used to infuse fluids or drain fluids from a patient.
A method of making a catheter includes obtaining a hollow tube having a proximal section, a distal section, an elongated conduit, and one or more fluid openings formed in the distal section of the hollow tube that are in fluid communication with the elongated lumen. The method includes inserting a mandrel within the elongated lumen, positioning a first visible marker over an outer surface of the hollow tube at a junction of the proximal and distal sections of the hollow tube, and placing a sacrificial material over the first visible marker to completely cover the first visible marker. Heat is applied for shrinking the sacrificial material, which, in turn, compresses the first visible marker against the outer surface of the hollow tube, and for least partially melting the first visible marker for fusing the first visible marker to the outer surface of the hollow tube.
A method of dispensing surgical fasteners includes providing an applicator instrument having a housing with a cartridge opening, an elongated shaft extending from the housing, a firing system disposed within the housing for dispensing surgical fasteners, and an actuator for activating the firing system. The method includes forming a surgical opening in tissue, inserting a distal end of the elongated shaft into the surgical opening, inserting a cartridge containing a plurality of first surgical fasteners into the cartridge opening, and engaging the actuator for dispensing one of the first surgical fasteners from the distal end of the elongated shaft. While maintaining the distal end of the elongated shaft inside the surgical opening, the cartridge is removed from the cartridge opening, a second cartridge containing a plurality of second surgical fasteners is inserted into the cartridge opening, and the actuator is engaged for dispensing one of the second surgical fasteners from the distal end of the elongated shaft.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/92 - Identification means for patients or instruments, e.g. tags coded with colour
86.
CATHETERS HAVING VISIBLE MARKERS FOR IDENTIFYING SOAKER REGIONS CONTAINING FLUID OPENINGS
A catheter for delivering fluids includes a hollow tube having a proximal section, a distal section, and an elongated lumen that extends through the proximal and distal sections of the hollow tube. One or more fluid openings are formed in the distal section of the hollow tube, which are in fluid communication with the elongated lumen of the hollow tube. A visible marker collar is secured to an outer surface of the hollow tube and is located at a junction of the proximal and distal sections of the hollow tube. A visible marker filament is disposed within the elongated lumen of the hollow tube and extends between the junction of the proximal and distal sections of the hollow tube and a distal end of the hollow tube. The visible markers are used to identify a soaker region of the catheter used to infuse fluids or drain fluids from a patient.
An applicator instrument for dispensing surgical fasteners includes a housing, and an elongated shaft extending from the housing. The elongated shaft has a proximal end secured to the housing, a distal end spaced from the proximal end, and a first axis extending between the proximal and distal ends of the elongated shaft. Surgical fasteners are disposed in the elongated shaft. The surgical fasteners are stacked at an angle relative to the first axis of the elongated shaft. A distal end cap having a surgical fastener dispensing window is secured to the distal end of the elongated shaft. The applicator instrument has a firing system disposed in the housing, and an actuator coupled with the firing system for activating the firing system to dispense the surgical fasteners through the surgical fastener dispensing window.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 17/29 - Forceps for use in minimally invasive surgery
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
88.
CATHETER WITH CARBON DIOXIDE DELIVERY SYSTEM AND METHODS
A system for creating separation between biological surfaces may comprise a hollow body configured for delivery of a fluid to a target location, a fluid supply in fluid-communication with the hollow body, a control element configured to control the delivery of a fluid through the hollow body, at least one first sensor configured to measure at least one parameter of the fluid flowing through the hollow body, at least one second sensor configured to measure at least one parameter of an environment of the hollow body, a feedback control module configured to receive information from one or more of the at least one first sensor or the at least one of the second sensor to control at least one operational function of the system.
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
89.
METHOD AND DEVICE FOR INTRMYOCARDIAL INFUSION OF CONDUCTIVE NANOPARTICLES
An injection catheter (300) for the improvement of intramyocardial conduction delay, the catheter comprising: a catheter body; a tip section (312) comprising a needle passage; a needle control handle (308); an injection needle (314) which is longitudinally slidable so that the distal end of the injection needle extends beyond the distal end of the tip section upon suitable manipulation of the needle control handle; and a needle stop disposed on a portion of the injection needle, wherein the needle stop has a distal end that is sized to prevent passage of the portion of the injection needle on which the needle stop is mounted from passing into the distal region of the needle passage thereby limiting a distance that the injection needle is capable of extending beyond the distal end of the tip section.
The present disclosure relates to systems and methods to magnetically influence the position, orientation, movement, and/or activation of a medical device within an operating region within the body using a magnetic guidance system introduced into a target location of a body. More specifically, the present disclosure relates to magnetic navigation systems for applying a magnetic field to an operating region within the body, the system comprising a first magnet assembly configured for introduction into a target location of a body and a second magnet assembly disposed opposite the first magnet assembly, wherein the first and second magnet assemblies are configured for applying a magnetic field to an operating region between the magnet assemblies.
A system for creating separation between biological surfaces may comprise a hollow body configured for delivery of a fluid to a target location, a fluid supply in fluid-communication with the hollow body, a control element configured to control the delivery of a fluid through the hollow body, at least one first sensor configured to measure at least one parameter of the fluid flowing through the hollow body, at least one second sensor configured to measure at least one parameter of an environment of the hollow body, a feedback control module configured to receive information from one or more of the at least one first sensor or the at least one of the second sensor to control at least one operational function of the system.
A61M 13/00 - Insufflators for therapeutic or disinfectant purposes
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Disclosed herein are methods to restore myocardial conduction via the injection of conductive nanoparticles into the myocardium via an endovascular injection catheter.
A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor with a catheter
93.
NEGATIVE PRESSURE WOUND THERAPY DEVICE HAVING HELICAL ELEMENTS
A device is configured for use in negative pressure wound therapy (NPWT). The device includes a tube having a tube proximal end and a tube distal end and A coil having a plurality of windings extending from a coil proximal end to a coil distal end. The coil distal end is coupled to the tube proximal end in a manner that enables application of a negative pressure from within the coil through the coil to tissue surrounding the coil. The coil comprises a space between adjacent ones of the plurality of windings, the space having a predetermined dimension.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
94.
Negative Pressure Wound Therapy Device Having Helical Elements
A device is configured for use in negative pressure wound therapy (NPWT). The device includes a tube having a tube proximal end and a tube distal end and A coil having a plurality of windings extending from a coil proximal end to a coil distal end. The coil distal end is coupled to the tube proximal end in a manner that enables application of a negative pressure from within the coil through the coil to tissue surrounding the coil. The coil comprises a space between adjacent ones of the plurality of windings, the space having a predetermined dimension.
The present invention is directed to a hemostatic patch comprising a porous substrate and at least a pair of co-reactive polymer reagents comprising at least one nucleophilic polyalkylene oxide based component and at least one electrophilic polyalkylene oxide-based on the porous substrate in a molar ratio of about 0.2 to about 0.9:1 of primary nucleophilic groups in excess to available electrophilic groups. The present invention is also directed to processes for the manufacture and use of such hemostatic patches.
The present invention is directed to suturing systems having a needle, an elongated flexible suture having a connecting end attached to a said needle and an opposing free end and at least one elongated external beneficial filament that is attached to said needle or attached to said suture at the connecting end. The beneficial filament has a smaller cross-sectional area and lower mechanical strength than the suture and contains a medicant.
Disclosed herein are two-component flowable compositions comprised of: (i) a powder of: oxidized cellulose, fibrinogen and thrombin, with the weight ratio of the oxidized cellulose to the fibrinogen ranging from about 1: 5 to about 2: 1, respectively; and (ii) a dispersant comprised of glycerol and an aqueous solution, the composition being in the form of a pasty suspension at a room temperature. Also disclosed are uses of the compositions for treating a bleeding tissue, and methods for making the compositions.
The present invention is directed to suturing systems having a needle, an elongated flexible suture having a connecting end attached to a said needle and an opposing free end and at least one elongated external beneficial filament that is attached to said needle or attached to said suture at the connecting end. The beneficial filament has a smaller cross-sectional area and lower mechanical strength than the suture and contains a medicant.
A method for removing tissues may comprise disposing a tissue resection device at a target tissue site, causing the tissue resection device to resect a core of tissue from the target tissue site, removing the core of tissue from the body, wherein the removing the core of tissue from the body creates a core cavity at the target tissue site.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
100.
SYSTEMS, DEVICES AND METHODS FOR DISPENSING FLOWABLE HEMOSTATS THAT INCORPORATE SAFETY MECHANISMS FOR PREVENTING AIR EMBOLISMS
A dispensing system includes a hollow tube having an outer wall with an air vent formed in the outer wall. A valve including a flexible flap is disposed inside the tube. The flexible flap, normally biased into a retracted position, is moveable between an extended position for sealing the air vent and the retracted position for unsealing the air vent. A syringe connector interconnects a syringe with the proximal end of the hollow tube and defines a fluid flow path. A flowable viscous fluid is disposed within the syringe. When a syringe plunger is depressed, the flowable viscous fluid is expelled from the syringe and forced through the fluid flow path and into the proximal end of the hollow tube. When the flowable viscous fluid engages the flexible flap, the flexible flap is forced to move into a position that seals the air vent.
