05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Préparations pharmaceutiques pour la prévention et le traitement du système nerveux central, à savoir les infections du système nerveux central, les maladies du cerveau, les troubles du mouvement du système nerveux central, les troubles de la motilité oculaire, les maladies de la moelle épinière; préparations pharmaceutiques pour la prévention et le traitement de maladies immunologiques, à savoir des maladies auto-immunes, des syndromes de déficit immunitaire; préparations pharmaceutiques pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques pour la prévention et le traitement du diabète; préparations pharmaceutiques pour la prévention et le traitement des troubles métaboliques, à savoir le diabète, l'obésité, l'hyperlipidémie, la résistance à l'insuline, le syndrome métabolique; anti-inflammatoires; préparations pharmaceutiques pour la prévention et le traitement des troubles du système respiratoire; préparations pharmaceutiques pour la prévention et le traitement des troubles du système musculo-squelettique, à savoir les maladies du tissu conjonctif, les maladies des os, les maladies de la colonne vertébrale, les maux de dos, les fractures, les entorses, les blessures du cartilage; préparations pharmaceutiques pour la prévention et le traitement des maladies génito-urinaires, à savoir les maladies urologiques, l'infertilité, les maladies sexuellement transmissibles, les inflammations pelviennes; préparations pharmaceutiques utilisées en dermatologie, à savoir la dermatite, les maladies affectant la pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques utilisées en oncologie; préparations pharmaceutiques utilisées en hématologie, à savoir pour le traitement des troubles sanguins; préparations pharmaceutiques utilisées pour la transplantation de tissus et d'organes; préparations pharmaceutiques utilisées en ophtalmologie; préparations pharmaceutiques utilisées en gastroentérologie; préparations pharmaceutiques pour la prévention et le traitement des troubles et des maladies oculaires; anti-infectieux, antibactériens, antiviraux, antibiotiques, antifongiques systémiques et topiques; tous les produits précités à usage humain.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma; all the aforesaid goods for human use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Préparations pharmaceutiques pour la prévention et le traitement du système nerveux central, à savoir les infections du système nerveux central, les maladies du cerveau, les troubles du mouvement du système nerveux central, les troubles de la motilité oculaire, les maladies de la moelle épinière; préparations pharmaceutiques pour la prévention et le traitement de maladies immunologiques, à savoir des maladies auto-immunes, des syndromes de déficit immunitaire; préparations pharmaceutiques pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques pour la prévention et le traitement du diabète; préparations pharmaceutiques pour la prévention et le traitement des troubles métaboliques, à savoir le diabète, l'obésité, l'hyperlipidémie, la résistance à l'insuline, le syndrome métabolique; anti-inflammatoires; préparations pharmaceutiques pour la prévention et le traitement des troubles du système respiratoire; préparations pharmaceutiques pour la prévention et le traitement des troubles du système musculo-squelettique, à savoir les maladies du tissu conjonctif, les maladies des os, les maladies de la colonne vertébrale, les maux de dos, les fractures, les entorses, les blessures du cartilage; préparations pharmaceutiques pour la prévention et le traitement des maladies génito-urinaires, à savoir les maladies urologiques, l'infertilité, les maladies sexuellement transmissibles, les inflammations pelviennes; préparations pharmaceutiques utilisées en dermatologie, à savoir la dermatite, les maladies affectant la pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques utilisées en oncologie; préparations pharmaceutiques utilisées en hématologie, à savoir pour le traitement des troubles sanguins; préparations pharmaceutiques utilisées pour la transplantation de tissus et d'organes; préparations pharmaceutiques utilisées en ophtalmologie; préparations pharmaceutiques utilisées en gastroentérologie; préparations pharmaceutiques pour la prévention et le traitement des troubles et des maladies oculaires; anti-infectieux, antibactériens, antiviraux, antibiotiques, antifongiques systémiques et topiques; tous les produits précités à usage humain.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma; all the aforesaid goods for human use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Préparations pharmaceutiques à usage humain pour la prévention et le traitement du système nerveux central, à savoir infections du système nerveux central, maladies cérébrales, troubles du mouvement du système nerveux central, troubles de la motilité oculaire, maladies de la moelle épinière; préparations pharmaceutiques à usage humain pour la prévention et le traitement de maladies immunologiques, à savoir maladies auto-immunes, syndromes d'immunodéficience; préparations pharmaceutiques à usage humain pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques à usage humain pour la prévention et le traitement de diabètes; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles métaboliques, à savoir diabète, obésité, hyperlipidémie, résistance à l'insuline, syndrome métabolique; anti-inflammatoires à usage humain; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles du système respiratoire; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles du système musculo-squelettique, à savoir maladies du tissu conjonctif, maladies osseuses, maladies rachidiennes, douleurs dorsales, fractures, entorses, blessures cartilagineuses; préparations pharmaceutiques à usage humain pour la prévention et le traitement de maladies génito- urinaires, à savoir maladies urologiques, infertilité, maladies sexuellement transmissibles, maladies pelviennes inflammatoires; préparations pharmaceutiques à usage humain à utiliser en dermatologie, à savoir pour les dermatites, les maladies de pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques à usage humain utilisées en oncologie; préparations pharmaceutiques à usage humain à utiliser en hématologie, à savoir pour le traitement de troubles sanguins; préparations pharmaceutiques à usage humain utilisées dans le cadre de la transplantation d'organes et de tissus; préparations pharmaceutiques à usage humain utilisées en ophtalmologie; préparations pharmaceutiques à usage humain utilisées en gastro-entérologie; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles et maladies oculaires; anti-infectieux à usage humain, antibactériens à usage humain, antiviraux à usage humain, antibiotiques à usage humain, antifongiques systémiques et topiques à usage humain.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Préparations pharmaceutiques à usage humain pour la prévention et le traitement du système nerveux central, à savoir les infections du système nerveux central, les maladies du cerveau, les troubles du mouvement du système nerveux central, les troubles de la motilité oculaire, les maladies de la moelle épinière; préparations pharmaceutiques à usage humain pour la prévention et le traitement de maladies immunologiques, à savoir des maladies auto-immunes, des syndromes de déficit immunitaire; préparations pharmaceutiques à usage humain pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques à usage humain pour la prévention et le traitement du diabète; préparations pharmaceutiques à usage humain pour la prévention et le traitement des troubles métaboliques, à savoir le diabète, l'obésité, l'hyperlipidémie, la résistance à l'insuline, le syndrome métabolique; anti-inflammatoires à usage humain; préparations pharmaceutiques à usage humain pour la prévention et le traitement des troubles du système respiratoire; préparations pharmaceutiques à usage humain pour la prévention et le traitement des troubles du système musculo-squelettique, à savoir les maladies du tissu conjonctif, les maladies des os, les maladies de la colonne vertébrale, les maux de dos, les fractures, les entorses, les blessures du cartilage; préparations pharmaceutiques à usage humain pour la prévention et le traitement des maladies génito-urinaires, à savoir les maladies urologiques, l'infertilité, les maladies sexuellement transmissibles, les inflammations pelviennes; préparations pharmaceutiques à usage humain utilisées en dermatologie, à savoir la dermatite, les maladies affectant la pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques à usage humain utilisées en oncologie; préparations pharmaceutiques à usage humain utilisées en hématologie, à savoir pour le traitement des troubles sanguins; préparations pharmaceutiques à usage humain utilisée pour la transplantation de tissus et d'organes; préparations pharmaceutiques à usage humain utilisées en ophtalmologie; préparations pharmaceutiques à usage humain utilisées en gastroentérologie; préparations pharmaceutiques à usage humain pour la prévention et le traitement des troubles et des maladies oculaires; anti-infectieux à usage humain, antibactériens à usage humain, antiviraux à usage humain, antibiotiques à usage humain, antifongiques systémiques et topiques à usage humain.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Préparations pharmaceutiques à usage humain pour la prévention et le traitement du système nerveux central, à savoir les infections du système nerveux central, les maladies du cerveau, les troubles du mouvement du système nerveux central, les troubles de la motilité oculaire, les maladies de la moelle épinière; préparations pharmaceutiques à usage humain pour la prévention et le traitement de maladies immunologiques, à savoir des maladies auto-immunes, des syndromes de déficit immunitaire; préparations pharmaceutiques à usage humain pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques à usage humain pour la prévention et le traitement du diabète; préparations pharmaceutiques à usage humain pour la prévention et le traitement des troubles métaboliques, à savoir le diabète, l'obésité, l'hyperlipidémie, la résistance à l'insuline, le syndrome métabolique; anti-inflammatoires à usage humain; préparations pharmaceutiques à usage humain pour la prévention et le traitement des troubles du système respiratoire; préparations pharmaceutiques à usage humain pour la prévention et le traitement des troubles du système musculo-squelettique, à savoir les maladies du tissu conjonctif, les maladies des os, les maladies de la colonne vertébrale, les maux de dos, les fractures, les entorses, les blessures du cartilage; préparations pharmaceutiques à usage humain pour la prévention et le traitement des maladies génito-urinaires, à savoir les maladies urologiques, l'infertilité, les maladies sexuellement transmissibles, les inflammations pelviennes; préparations pharmaceutiques à usage humain utilisées en dermatologie, à savoir la dermatite, les maladies affectant la pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques à usage humain utilisées en oncologie; préparations pharmaceutiques à usage humain utilisées en hématologie, à savoir pour le traitement des troubles sanguins; préparations pharmaceutiques à usage humain utilisée pour la transplantation de tissus et d'organes; préparations pharmaceutiques à usage humain utilisées en ophtalmologie; préparations pharmaceutiques à usage humain utilisées en gastroentérologie; préparations pharmaceutiques à usage humain pour la prévention et le traitement des troubles et des maladies oculaires; anti-infectieux à usage humain, antibactériens à usage humain, antiviraux à usage humain, antibiotiques à usage humain, antifongiques systémiques et topiques à usage humain.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives for human use; anti-inflammatories for human use; antibacterial pharmaceutical preparations for human use; antibiotics for human use; antifungal preparations for human use; antivirals for human use; cardiovascular pharmaceutical preparations for human use; dermatological pharmaceutical preparations for human use; pharmaceutical preparations for human use for inhaling for prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations for human use acting on the central nervous system; pharmaceutical preparations and substances for human use for prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for human use for prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculoskeletal system and the genitourinary system; pharmaceutical preparations for human use in hematology and in tissue and organ transplantation; pharmaceutical preparations for human use for prevention and treatment of eye diseases; pharmaceutical preparations for human use for prevention and treatment of heart rhythm disorders; pharmaceutical preparations for human use for prevention and treatment of diseases and disorders related to the immune system; pharmaceutical preparations for human use for prevention and treatment of kidney diseases; pharmaceutical preparations for human use for prevention and treatment of diabetes; pharmaceutical preparations for human use for prevention and treatment of hypertension; pharmaceutical preparations for human use for prevention and treatment of skin conditions; pharmaceutical preparations for human use in dermatology; pharmaceutical preparations for human use in urology; pharmaceutical preparations for human use in ophthalmology; pharmaceutical preparations for human use for prevention and treatment of cancer and tumors; pharmaceutical preparations for human use for prevention and treatment of allergies; pharmaceutical preparations for human use for prevention and treatment of bone diseases; pharmaceutical preparations for human use for prevention and treatment of respiratory diseases and asthma
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives for human use; anti-inflammatories for human use; antibacterial pharmaceutical preparations for human use; antibiotics for human use; antifungal preparations for human use; antivirals for human use; cardiovascular pharmaceutical preparations for human use; dermatological pharmaceutical preparations for human use; pharmaceutical preparations for human use for inhaling for prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations for human use acting on the central nervous system; pharmaceutical preparations and substances for human use for prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for human use for prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculoskeletal system and the genitourinary system; pharmaceutical preparations for human use in hematology and in tissue and organ transplantation; pharmaceutical preparations for human use for prevention and treatment of eye diseases; pharmaceutical preparations for human use for prevention and treatment of heart rhythm disorders; pharmaceutical preparations for human use for prevention and treatment of diseases and disorders related to the immune system; pharmaceutical preparations for human use for prevention and treatment of kidney diseases; pharmaceutical preparations for human use for prevention and treatment of diabetes; pharmaceutical preparations for human use for prevention and treatment of hypertension; pharmaceutical preparations for human use for prevention and treatment of skin conditions; pharmaceutical preparations for human use in dermatology; pharmaceutical preparations for human use in urology; pharmaceutical preparations for human use in ophthalmology; pharmaceutical preparations for human use for prevention and treatment of cancer and tumors; pharmaceutical preparations for human use for prevention and treatment of allergies; pharmaceutical preparations for human use for prevention and treatment of bone diseases; pharmaceutical preparations for human use for prevention and treatment of respiratory diseases and asthma.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma; all the aforesaid goods for human use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Préparations pharmaceutiques pour la prévention et le traitement du système nerveux central, à savoir les infections du système nerveux central, les maladies du cerveau, les troubles du mouvement du système nerveux central, les troubles de la motilité oculaire, les maladies de la moelle épinière; préparations pharmaceutiques pour la prévention et le traitement de maladies immunologiques, à savoir des maladies auto-immunes, des syndromes de déficit immunitaire; préparations pharmaceutiques pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques pour la prévention et le traitement du diabète; préparations pharmaceutiques pour la prévention et le traitement des troubles métaboliques, à savoir le diabète, l'obésité, l'hyperlipidémie, la résistance à l'insuline, le syndrome métabolique; anti-inflammatoires; préparations pharmaceutiques pour la prévention et le traitement des troubles du système respiratoire; préparations pharmaceutiques pour la prévention et le traitement des troubles du système musculo-squelettique, à savoir les maladies du tissu conjonctif, les maladies des os, les maladies de la colonne vertébrale, les maux de dos, les fractures, les entorses, les blessures du cartilage; préparations pharmaceutiques pour la prévention et le traitement des maladies génito-urinaires, à savoir les maladies urologiques, l'infertilité, les maladies sexuellement transmissibles, les inflammations pelviennes; préparations pharmaceutiques utilisées en dermatologie, à savoir la dermatite, les maladies affectant la pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques utilisées en oncologie; préparations pharmaceutiques utilisées en hématologie, à savoir pour le traitement des troubles sanguins; préparations pharmaceutiques utilisée pour la transplantation de tissus et d'organes; préparations pharmaceutiques utilisées en ophtalmologie; préparations pharmaceutiques utilisées en gastroentérologie; préparations pharmaceutiques pour la prévention et le traitement des troubles et des maladies oculaires; anti-infectieux, antibactériens, antiviraux, antibiotiques, antifongiques systémiques et topiques; tous les produits précités à usage humain.
Avacincaptad pegol, also known under the trademarks Izervay or Zimura, is a molecule comprising an aptamer sequence and a polyethylene glycol polymer (PEG) -moiety. The aptamer sequence binds to complement C5-protein, which C5 protein is known to be involved in many eye diseases. Avacincaptad pegol is approved to treat Age-related Macular Degeneration (AMD) secondary to Geographic Atrophy (GA) and is applied by intravitreal injection into the eye. The pharmaceutical product is currently only offered as a liquid in a vial. This patent application discloses Avacincaptad in a more stable presentation, namely in a pre-filled syringe, which surprisingly results in very significantly improved stability of the product.
A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
The present invention relates to an inhaler device for use with an elongate strip medicament carrier comprising a base with a plurality of medicament pockets or blisters and a peelable lidding sheet covering the blisters, the inhaler device comprising; an indexer movable in a first direction to advance a blister pocket into an inhalation position; an opening system for peeling the peelable lidding sheet from the base to expose medicament within each medicament pocket; the opening system comprising a peel management component movable in a first direction corresponding to said first direction of the indexer to delay the peeling action when the indexer is advanced, and in a second, opposite, direction to allow the lidding sheet to be peeled from the base; wherein the indexer and peel management component are separately driven in said first direction so that movement of the indexer does not dictate movement of the peel management component.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives for human use; anti-inflammatories for human use; antibacterial pharmaceutical preparations for human use; antibiotics for human use; antifungal preparations for human use; antivirals for human use; cardiovascular pharmaceutical preparations for human use; dermatological pharmaceutical preparations for human use; pharmaceutical preparations for human use for inhaling for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations for human use acting on the central nervous system; pharmaceutical preparations and substances for human use for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for human use for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculoskeletal system and the genitourinary system; pharmaceutical preparations for human use, used in hematology and in tissue and organ transplantation; pharmaceutical preparations for human use for the prevention and treatment of eye diseases; pharmaceutical preparations for human use for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for human use for the prevention and treatment of diseases and disorders related to the immune system; pharmaceutical preparations for human use for the prevention and treatment of kidney diseases; pharmaceutical preparations for human use for the prevention and treatment of diabetes; pharmaceutical preparations for human use for the prevention and treatment of hypertension; pharmaceutical preparations for human use for the prevention and treatment of skin conditions; pharmaceutical preparations for human use, used in dermatology; pharmaceutical preparations for human use, used in urology; pharmaceutical preparations for human use, used in ophthalmology; pharmaceutical preparations for human use for the prevention and treatment of cancer and tumors; pharmaceutical preparations for human use for the prevention and treatment of allergies; pharmaceutical preparations for human use for the prevention and treatment of bone diseases; pharmaceutical preparations for human use for the prevention and treatment of respiratory diseases and asthma
The present invention relates to novel crystalline forms of Elacestrant dihydrochloride. The present invention also relates to a pharmaceutical composition comprising the crystalline forms of Elacestrant dihydrochloride of the present invention, as well of methods of using the same in the treatment of conditions and diseases driven by estrogen, preferably for the treatment of breast cancer.
C07C 217/84 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Pharmaceutical preparations for the prevention and treatment of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases; pharmaceutical preparations for the prevention and treatment of immunologic diseases, namely, autoimmune diseases, immunologic deficiency syndromes; pharmaceutical preparations for the prevention and treatment of cardiovascular diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of metabolic disorders, namely, diabetes, obesity, hyperlipidemia, insulin resistance, metabolic syndrome; anti-inflammatories; pharmaceutical preparations for the prevention and treatment of disorders of the musculo-skeletal system, namely, connective tissue diseases, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries; pharmaceutical preparations for the prevention and treatment of genitourinary diseases, namely, urological diseases, infertility, sexually transmitted diseases, inflammatory pelvic diseases; pharmaceutical preparations for use in dermatology, namely, dermatitis, skin pigmentation diseases, sexually transmitted diseases; pharmaceutical preparations for use in oncology; pharmaceutical preparations for use in hematology, namely for the treatment of blood disorders; pharmaceutical preparations for use in tissue and organ transplantation; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for prevention and treatment of ocular disorders and diseases; anti-infectives, antibacterials, antivirals, antibiotics, systemic and topical antifungals.
The present invention relates to vorasidenib solid-state forms, to a pharmaceutical composition comprising them, and to processes for their preparation.
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
The present invention relates to Tapinarof dimethylacetamide solvate and crystalline forms thereof, processes for preparation and pharmaceutical compositions thereof. Furthermore, the invention concerns its use for the preparation of a medicament, preferably for the treatment of skin diseases.
C07C 39/21 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic part, with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
C07C 233/05 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
The present invention refers to a process for preparing sucrose octasulfate octakistriethylammonium salt (TASOS) powder, comprising the steps of combining a TASOS solution with a polar organic solvent(s) and triethylamine, thereby obtaining a TASOS solution, the polar organic solvent(s), and triethylamine; concentrating said TASOS solution; combining it with 2-methyltetrahydrofuran and/or tetrahydrofuran and triethylamine, thereby obtaining a mixture; and stirring said mixture until a white TASOS powder is obtained.
The present invention refers to a process for preparing sucrose octasulfate octakistriethylammonium salt (TASOS) powder, comprising the steps of combining a TASOS solution with a polar organic solvent(s) and triethylamine, thereby obtaining a TASOS solution, the polar organic solvent(s), and triethylamine; concentrating said TASOS solution; combining it with 2-methyltetrahydrofuran and/or tetrahydrofuran and triethylamine, thereby obtaining a mixture; and stirring said mixture until a white TASOS powder is obtained.
The present invention also refers to a sucrose octasulfate octakistriethylammonium salt (TASOS) powder having a purity of at least 96%, the use of the sucrose octasulfate octakistriethylammonium salt (TASOS) powder for preparing a pharmaceutical composition, and the use of tetrahydrofuran or 2-methyltetrahydrofuran as antisolvent for the preparation of TASOS powder.
The present invention refers to a process for preparing sucrose octasulfate octakistriethylammonium salt (TASOS) powder, comprising the steps of combining a TASOS solution with a polar organic solvent(s) and triethylamine, thereby obtaining a TASOS solution, the polar organic solvent(s), and triethylamine; concentrating said TASOS solution; combining it with 2-methyltetrahydrofuran and/or tetrahydrofuran and triethylamine, thereby obtaining a mixture; and stirring said mixture until a white TASOS powder is obtained.
The present invention also refers to a sucrose octasulfate octakistriethylammonium salt (TASOS) powder having a purity of at least 96%, the use of the sucrose octasulfate octakistriethylammonium salt (TASOS) powder for preparing a pharmaceutical composition, and the use of tetrahydrofuran or 2-methyltetrahydrofuran as antisolvent for the preparation of TASOS powder.
Finally, the present invention refers to a pharmaceutical composition prepared by using the sucrose octasulfate octakistriethylammonium salt (TASOS) powder of the present invention, and to the pharmaceutical composition for use in treating cancer.
The present invention relates to solid-state forms of 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide methane sulfonic acid (INN: belumosudil mesylate) and processes for their preparation. Furthermore, the invention relates to a pharmaceutical composition comprising a solid-state form of the present invention and at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment and/or prophylaxis of autoimmune diseases such as graft-versus-host disease (GvHD) and systemic sclerosis.
C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-infectives; anti-inflammatories; antibacterial pharmaceuticals; antibiotics; antifungal preparations; antivirals; cardiovascular pharmaceuticals; dermatological pharmaceutical preparations; inhaled pharmaceutical preparations for the prevention and treatment of respiratory diseases and disorders; pharmaceutical preparations acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of gastro-intestinal diseases; pharmaceutical preparations for the prevention and treatment of diseases and disorders of the autoimmune system, the metabolic system, the endocrine system, the musculo-skeletal system and the genitourinary system; pharmaceutical preparations for use in hematology and in tissue and organ transplantation; pharmaceutical preparations for the prevention and treatment of eye diseases and conditions; pharmaceutical preparations for the prevention and treatment of heart rhythm disorders; pharmaceutical preparations for the prevention and treatment of immune system related diseases and disorders; pharmaceutical preparations for the prevention and treatment of kidney diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of hypertension; pharmaceutical preparations for the prevention and treatment of skin disorders; pharmaceutical preparations for use in dermatology; pharmaceutical preparations for use in urology; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer and tumors; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of bone diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases and asthma
94.
MANDELATE FORM OF 1-(4-(((6-AMINO-5-(4-PHENOXYPHENYL)PYRIMIDIN-4-YL)AMINO)METHYL)PIPERIDIN-1-YL)PROP-2-EN-1-ONE
The present invention relates to a mandelate form of 1-(4-(((6-amino-5-(4-phenoxyphenyl) pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one (INN: evobrutinib) and a process of producing the same. Furthermore, the invention relates to a pharmaceutical composition comprising the mandelate form of evobrutinib and at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment and/or prevention of multiple sclerosis.
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
The present invention relates to aqueous high protein concentration compositions, particularly pharmaceutical compositions. The pharmaceutical compositions are useful for delivery of high concentration of the protein active ingredient, such as an antibody, to a patient without high levels of protein aggregation, or other destabilizing factors. The compositions of the invention comprise about 100 mg/mL or more of protein.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The present invention relates to a crystalline form of sotorasib and to a process for its preparation. Furthermore, the invention relates to a pharmaceutical composition comprising the crystalline form of sotorasib of the present invention and at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment of a cancer with a KRAS mutation.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Préparations pharmaceutiques à usage humain pour la prévention et le traitement du système nerveux central, à savoir infections du système nerveux central, maladies cérébrales, troubles du mouvement du système nerveux central, troubles de la motilité oculaire, maladies de la moelle épinière; préparations pharmaceutiques à usage humain pour la prévention et le traitement de maladies immunologiques, à savoir maladies auto-immunes, syndromes d'immunodéficience; préparations pharmaceutiques à usage humain pour la prévention et le traitement des maladies cardiovasculaires; préparations pharmaceutiques à usage humain pour la prévention et le traitement de diabètes; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles métaboliques, à savoir diabète, obésité, hyperlipidémie, résistance à l'insuline, syndrome métabolique; anti-inflammatoires à usage humain; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles du système respiratoire; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles du système musculo squelettique, à savoir maladies du tissu conjonctif, maladies osseuses, maladies rachidiennes, douleurs dorsales, fractures, entorses, blessures cartilagineuses; préparations pharmaceutiques à usage humain pour la prévention et le traitement de maladies génito-urinaires, à savoir maladies urologiques, infertilité, maladies sexuellement transmissibles, maladies pelviennes inflammatoires; préparations pharmaceutiques à usage humain à utiliser en dermatologie, à savoir pour les dermatites, les maladies de pigmentation de la peau, les maladies sexuellement transmissibles; préparations pharmaceutiques à usage humain utilisées en oncologie; préparations pharmaceutiques à usage humain à utiliser en hématologie, à savoir pour le traitement de troubles sanguins; préparations pharmaceutiques à usage humain utilisées dans le cadre de la transplantation d'organes et de tissus; préparations pharmaceutiques à usage humain utilisées en ophtalmologie; préparations pharmaceutiques à usage humain utilisées en gastro-entérologie; préparations pharmaceutiques à usage humain pour la prévention et le traitement de troubles et maladies oculaires; anti infectieux à usage humain, antibactériens à usage humain, antiviraux à usage humain, antibiotiques à usage humain, antifongiques systémiques et topiques à usage humain.
