An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
A system includes a chuck configured to accept a sample block, a blade including a blade surface configured to remove a tissue section from the sample block, where the chuck is moveable relative to the blade surface of the blade, at least one sensor configured to sense a front face of the sample block, and a control system. The control system is configured to receive measurements from the at least one sensor, identify, from the measurements, a geometry of the front face, identify, based on the geometry, an alignment of the front face with respect to the blade surface of the blade, and cause the chuck or the blade to move relative to each other to align the front face relative to the blade surface.
G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
B26D 5/00 - Arrangements for operating and controlling machines or devices for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
B26D 7/26 - Means for mounting or adjusting the cutting memberMeans for adjusting the stroke of the cutting member
G01B 11/27 - Measuring arrangements characterised by the use of optical techniques for measuring angles or tapersMeasuring arrangements characterised by the use of optical techniques for testing the alignment of axes for testing the alignment of axes
G01B 11/30 - Measuring arrangements characterised by the use of optical techniques for measuring roughness or irregularity of surfaces
A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.
The present disclosure relates to systems and methods for tracking and printing within a histology system. In some embodiments, a system is provided that includes an information reader configured to read identifying data associated with a tissue block, a microtome configured to cut one or more tissue sections from the tissue block, one or more slides for receiving the one or more tissue sections, and a printer configured to receive the identifying data and print, after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one more tissue sections on the one or more slides with the tissue block.
There is provided an automated system for preparing tissue samples that comprises one or more microtomes, a hydration system, and a processor, the processor being programmed to initiate facing, by one or more microtomes, of a first tissue block comprising a first tissue sample embedded in an embedding material, and cause the first tissue block to be hydrated by the hydration system for a first predetermined time, and initiate facing, by one or more microtomes, of a second tissue block while the first tissue block is being hydrated, the second tissue block comprising a second tissue sample embedded in an embedding material, and cause the second tissue block to be hydrated by the hydration system for a second predetermined time, and to initiate the one or more microtomes to begin sectioning of the first tissue block while the second tissue block is being hydrated.
A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Laboratory equipment and supplies for clinical diagnostic purposes, namely microtome blades for laboratory use for use with tissue samples for pathology, histology or and other tissue analysis in the field of microtomy Laboratory equipment and supplies for clinical diagnostic purposes, namely microtome blades for use with tissue samples for pathology, histology or and other tissue analysis in the field of microtomy for medical use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Laboratory equipment and supplies for clinical diagnostic purposes, namely medical adhesive transfer tape for use with tissue samples for pathology, histology or and other tissue analysis in the field of microtomy for medical use Laboratory equipment and supplies for clinical diagnostic purposes, namely laboratory transfer tape for use with tissue samples for pathology, histology or and other tissue analysis in the field of microtomy Laboratory equipment and supplies for clinical diagnostic purposes, namely suture transfer tape for use with tissue samples for pathology, histology or and other tissue analysis in the field of microtomy for medical use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory equipment and supplies for clinical diagnostic purposes, namely slide coat medical adhesive tape for use with tissue samples for pathology, histology or and other tissue analysis in the field of microtomy for medical use Laboratory equipment and supplies for clinical diagnostic purposes, namely slide coat adhesive for laboratory use for use with tissue samples for pathology, histology or and other tissue analysis in the field of microtomy
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Laboratory equipment and supplies for clinical diagnostic purposes, namely, coverslip mounting medium being cover glass for microscope slides for laboratory use for use with tissue samples for pathology, histology, and other tissue analysis in the field of microtomy Laboratory equipment and supplies for clinical diagnostic purposes, namely medical specimen collection devices in the nature of coverslip mounting medium for the collection of tissue samples for use with tissue samples for pathology, histology, and other tissue analysis in the field of microtomy for medical use
A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.
A system includes a chuck configured to accept a sample block, a blade including a blade surface configured to remove a tissue section from the sample block, where the chuck is moveable relative to the blade surface of the blade, at least one sensor configured to sense a front face of the sample block, and a control system. The control system is configured to receive measurements from the at least one sensor, identify, from the measurements, a geometry of the front face, identify, based on the geometry, an alignment of the front face with respect to the blade surface of the blade, and cause the chuck or the blade to move relative to each other to align the front face relative to the blade surface.
There is provided a histology system that comprises a microtome configured to expose a face of a tissue block comprising a tissue sample embedded in an embedding material and remove one or more tissue sections from the sample, a hydration system configured to hydrate the tissue block by depositing a hydrating liquid on the face of the tissue block, and a transfer system configured to transfer the one or more tissue sections from the microtome to one or more slides. In some embodiments, the hydration system is configured to produce droplet condensation of the hydrating liquid and deposit the condensation on the face of the tissue block.
A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.
A sectioning system includes a chuck assembly configured to receive a tissue block, a cutting assembly configured to remove a tissue section from the tissue block, at least one sensor configured to sense data regarding dynamics of one or more components of at least one of the chuck assembly or the cutting assembly, and a control system. The control system is configured to receive data from the at least one sensor, determine whether the data from the at least one sensor shows normal behavior of the one or more components of at least one of the chuck assembly or the cutting assembly, and output a signal if it is determined the data from the at least one sensor does not show normal behavior of the one or more components.
A microtomy system includes a tissue chuck configured to accept a tissue block and a microtome blade configured to remove one or more tissue sections from the tissue block, the microtome blade being axially offset from the tissue chuck along a horizontal axis, where the microtome blade and the tissue chuck are axially displaceable relative to one another along the horizontal axis. The system also includes a control system configured to receive information indicative of a relative axial location of the microtome blade to the tissue chuck along the horizontal axis, and to use a control loop to control the relative axial location of the microtome blade to the tissue chuck such that the one or more tissue sections have a desired thickness.
A sectioning system includes a chuck assembly configured to receive a tissue block, a cutting assembly configured to remove a tissue section from the tissue block, at least one sensor configured to sense data regarding dynamics of one or more components of at least one of the chuck assembly or the cutting assembly, and a control system. The control system is configured to receive data from the at least one sensor, determine whether the data from the at least one sensor shows normal behavior of the one or more components of at least one of the chuck assembly or the cutting assembly, and output a signal if it is determined the data from the at least one sensor does not show normal behavior of the one or more components.
A microtomy system includes a tissue chuck configured to accept a tissue block and a microtome blade configured to remove one or more tissue sections from the tissue block, the microtome blade being axially offset from the tissue chuck along a horizontal axis, where the microtome blade and the tissue chuck are axially displaceable relative to one another along the horizontal axis. The system also includes a control system configured to receive information indicative of a relative axial location of the microtome blade to the tissue chuck along the horizontal axis, and to use a control loop to control the relative axial location of the microtome blade to the tissue chuck such that the one or more tissue sections have a desired thickness.
The present disclosure also relates to systems and methods for quality control in histology systems. In some embodiments, a method is provided that includes receiving a tissue block comprising a tissue sample embedded in an embedding material, imaging the tissue block to create a first imaging data of the tissue sample in a tissue section on the tissue block, removing the tissue section from the tissue block, the tissue section comprising a part of the tissue sample, imaging the tissue section to create a second imaging data of the tissue sample in the tissue section, and comparing the first imaging data to the second imaging data to confirm correspondence in the tissue sample in the first imaging data and the second imaging data based on one or more quality control parameters.
A composition of the present disclosure includes an aqueous dispersion of epoxy resin particles. The epoxy resin particles include at least two 1,2-epoxide groups. The composition further includes one or more anti-adhesive agents, one or more anti-microbial agents, or a combination of one or more anti-adhesive agents and one or more anti-microbial agents.
C08G 77/00 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon
C08G 77/42 - Block- or graft-polymers containing polysiloxane sequences
A composition of the present disclosure includes an aqueous dispersion of epoxy resin particles. The epoxy resin particles include at least two 1,2-epoxide groups. The composition further includes one or more anti-adhesive agents, one or more anti-microbial agents, or a combination of one or more anti-adhesive agents and one or more anti-microbial agents.
An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
There is provided an automated system for preparing tissue samples that comprises one or more microtomes, a hydration system, and a processor, the processor being programmed to initiate facing, by one or more microtomes, of a first tissue block comprising a first tissue sample embedded in an embedding material, and cause the first tissue block to be hydrated by the hydration system for a first predetermined time, and initiate facing, by one or more microtomes, of a second tissue block while the first tissue block is being hydrated, the second tissue block comprising a second tissue sample embedded in an embedding material, and cause the second tissue block to be hydrated by the hydration system for a second predetermined time, and to initiate the one or more microtomes to begin sectioning of the first tissue block while the second tissue block is being hydrated.
An integrated pathology system includes a tissue embedding module configured to embed a tissue sample into an embedding material to prepare a tissue block, a sectioning and slide creating module configured to remove one or more tissue sections from the tissue block and place the one or more tissue sections onto one or more slides, a staining module configured to stain the one or more tissue sections on the slides, and a cover-slipper module configured to place a cover onto the one or more stained tissue sections. The system further includes one or more transfer devices configured to integrate the modules and a processor in communication with the modules for controlling one or more processes performed by the modules and the one or more transfer devices for controlling the integration of the modules.
An integrated pathology system includes a tissue embedding module configured to embed a tissue sample into an embedding material to prepare a tissue block, a sectioning and slide creating module configured to remove one or more tissue sections from the tissue block and place the one or more tissue sections onto one or more slides, a staining module configured to stain the one or more tissue sections on the slides, and a cover-slipper module configured to place a cover onto the one or more stained tissue sections. The system further includes one or more transfer devices configured to integrate the modules and a processor in communication with the modules for controlling one or more processes performed by the modules and the one or more transfer devices for controlling the integration of the modules.
Provided here are systems and methods for microtomy, including a microtome and a transfer tape system. The microtome can be used for sectioning a tissue section from a tissue block. The transfer tape system can include a transfer tape configured to adhere to a front face of the tissue block and collect one or more tissue sections sectioned by the microtome and to transfer the one or more tissue sections to one or more slides; and at least one tension device for controlling tension and an angle of the transfer tape relative the tissue block or the one or more slides. The at least one tension device can be configured to maintain the transfer tape at a predetermined tension or maintain the transfer tape at a predetermined angle relative to the tissue block or the one or more slides.
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
Provided here are systems and methods for microtomy, including a microtome and a transfer tape system. The microtome can be used for sectioning a tissue section from a tissue block. The transfer tape system can include a transfer tape configured to adhere to a front face of the tissue block and collect one or more tissue sections sectioned by the microtome and to transfer the one or more tissue sections to one or more slides; and at least one tension device for controlling tension and an angle of the transfer tape relative the tissue block or the one or more slides. The at least one tension device can be configured to maintain the transfer tape at a predetermined tension or maintain the transfer tape at a predetermined angle relative to the tissue block or the one or more slides.
The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Scientific research apparatus, namely, automated tissue sectioning apparatus, collection apparatus and preparation apparatus for research and diagnostic use for cancer testing, other tissue testing and other tissue analysis Automated apparatus for collecting and preparing tissue samples for pathology, histology or other tissue analysis for medical use; automated tissue sectioning apparatus for medical use; automated microtomy apparatus for cutting tissue samples for medical use; automated apparatus for transferring sectioned tissue samples to tape for medical use; automated apparatus for transferring tissue samples to slides for pathology, histology or other tissue analysis for medical use; automated apparatus for the preparation of tissue specimen glass slides for pathology, histology or other tissue analysis for medical use; medical diagnostic tissue specimen glass slides for collecting and storing tissue samples and materials in the nature of cover glass for use with medical diagnostic glass slides for storing tissue samples; diagnostic tissue sample carrying tape for collecting and transferring multiple sectioned tissue specimens within the automated apparatus for medical use Medical laboratory services for tissue sectioning, collection and preparation; preparation of tissue sample slides for research and testing for scientific and medical research purposes; pathology and histology medical laboratory services; tissue testing services for scientific and medical research purposes; tissue analysis services for scientific and medical research purposes; electronic data storage relating to tissue imaging for medical diagnostic and analysis purposes Medical testing of tissue samples for diagnostic purposes; medical testing of tissue samples for treatment purposes; medical analysis services for the diagnosis and treatment of persons, including tissue preparation and analysis for pathology and histology purposes; tissue diagnostic testing services for medical purposes; tissue testing services for medical treatment purposes; tissue analysis services for medical purposes, namely, for diagnosis and treatment of persons; tissue imaging for medical analysis purposes, namely, for diagnosis and treatment of persons
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific research apparatus, namely, automated tissue sectioning apparatus, collection apparatus and preparation apparatus for research and diagnostic use for cancer testing, other tissue testing or other tissue analysis Automated apparatus for collecting and preparing tissue samples for pathology, histology or other tissue analysis for medical use; automated tissue sectioning apparatus for medical use; automated microtomy apparatus for cutting tissue samples for medical use; automated apparatus for transferring sectioned tissue samples to tape for medical use; automated apparatus for transferring tissue samples to slides for pathology, histology or other tissue analysis for medical use; automated apparatus for the preparation of tissue specimen glass slides for pathology, histology or other tissue analysis for medical use; diagnostic tissue sample carrying tape for collecting and transferring multiple sectioned tissue specimens within the automated apparatus for medical use
31.
Connected systems for automated tissue section preparation and methods of use thereof
Systems and methods enable fully automated tissue processing using tissue processing components for producing tissue sections from a tissue sample block and to transfer the tissue sections to slides. A control device queries a Laboratory Information Management System (LIMS) with a sample identifier associated with the tissue sample block and receives tissue sample data from the LIMS. The control device generates tissue processing workflow parameters based on the tissue sample data for each tissue processing component to perform an automated tissue processing workflow. The control device automatically controls each tissue processing component according to the tissue processing workflow parameters to process the tissue sample block. The control device generates a block processing update message while the tissue sample block is processed and communicates the block processing update message to the LIMS to enable the LIMS to track the automated tissue processing workflow for the tissue sample block.
Systems and methods enable fully automated tissue processing using tissue processing components for producing tissue sections from a tissue sample block and to transfer the tissue sections to slides. A control device queries a Laboratory Information Management System (LIMS) with a sample identifier associated with the tissue sample block and receives tissue sample data from the LIMS. The control device generates tissue processing workflow parameters based on the tissue sample data for each tissue processing component to perform an automated tissue processing workflow. The control device automatically controls each tissue processing component according to the tissue processing workflow parameters to process the tissue sample block. The control device generates a block processing update message while the tissue sample block is processed and communicates the block processing update message to the LIMS to enable the LIMS to track the automated tissue processing workflow for the tissue sample block.
A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.
A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.
A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
The present disclosure can implement systems and methods to increase throughput in an automated tissue sectioning apparatus to decrease the tissue sample preparation time for a plurality of tissue blocks. The present disclosure further provides a system and method for hydration of tissue samples.
There is provided a histology system that comprises a microtome configured to expose a face of a tissue block comprising a tissue sample embedded in an embedding material and remove one or more tissue sections from the sample, a hydration system configured to hydrate the tissue block by depositing a hydrating liquid on the face of the tissue block, and a transfer system configured to transfer the one or more tissue sections from the microtome to one or more slides. In some embodiments, the hydration system is configured to produce droplet condensation of the hydrating liquid and deposit the condensation on the face of the tissue block.
There is provided an automated system for preparing tissue samples that comprises one or more microtomes, a hydration system, and a processor, the processor being programmed to initiate facing, by one or more microtomes, of a first tissue block comprising a first tissue sample embedded in an embedding material, and cause the first tissue block to be hydrated by the hydration system for a first predetermined time, and initiate facing, by one or more microtomes, of a second tissue block while the first tissue block is being hydrated, the second tissue block comprising a second tissue sample embedded in an embedding material, and cause the second tissue block to be hydrated by the hydration system for a second predetermined time, and to initiate the one or more microtomes to begin sectioning of the first tissue block while the second tissue block is being hydrated.
The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.
The present disclosure also relates to systems and methods for quality control in histology systems. In some embodiments, a method is provided that includes receiving a tissue block comprising a tissue sample embedded in an embedding material, imaging the tissue block to create a first imaging data of the tissue sample in a tissue section on the tissue block, removing the tissue section from the tissue block, the tissue section comprising a part of the tissue sample, imaging the tissue section to create a second imaging data of the tissue sample in the tissue section, and comparing the first imaging data to the second imaging data to confirm correspondence in the tissue sample in the first imaging data and the second imaging data based on one or more quality control parameters.
The present disclosure relates to systems and methods for tracking and printing within a histology system. In some embodiments, a system is provided that includes an information reader configured to read identifying data associated with a tissue block, a microtome configured to cut one or more tissue sections from the tissue block, one or more slides for receiving the one or more tissue sections, and a printer configured to receive the identifying data and print, after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one more tissue sections on the one or more slides with the tissue block.
The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.
A histology system includes a microtome configured to produce a tissue section from a tissue block, where the tissue section includes a tissue sample, a transfer system including a transfer medium to transfer the tissue section to a slide, and a vision system. The vision system includes an illumination system configured to illuminate the tissue section on the transfer medium and an imaging system configured to create imaging data of the tissue section on the transfer medium illuminated by the illumination system. The histology system further includes a processor to receive the imaging data and perform one or more quality control analysis based on the imaging data, where the one or more analysis includes a comparative analysis of the tissue section on the transfer medium with at least one of the tissue section on the tissue block or the tissue section on the slide.
The present disclosure relates to systems and methods for tracking and printing within a histology system. In some embodiments, a system is provided that includes an information reader configured to read identifying data associated with a tissue block, a microtome configured to cut one or more tissue sections from the tissue block, one or more slides for receiving the one or more tissue sections, and a printer configured to receive the identifying data and print, after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one more tissue sections on the one or more slides with the tissue block.
The present disclosure relates to systems and methods for facing and quality control decisions in microtomy. In some embodiments, a histology system is provided, which comprises a microtome configured to progressively remove one or more sections from a tissue block, the tissue block comprising a tissue sample embedded in an embedding material; and a vision system associated with the microtome and comprising: an illumination system configured to illuminate the tissue block comprising a tissue sample embedded in an embedding material; an imaging system configured to image the tissue block to generate imaging data associated with the tissue block; and a processor in communication with the vision system, the processor being programed to receive the imaging data and perform facing and quality control analysis.
Three dimensional tumor volume is analyzed spatially by genomics and transcriptomics, or both. Thin sections are cut with a microtome using a tape transfer technique so that the thin tissue sections remain without any distortion or deformation, in sequence relative to their position in the original tissue, so that a three-dimensional coordinate system can be anchored to each tissue section. Small samples of tissue are extracted or punched from very precise locations in the supports using the coordinate system as a grid, with known x,y,z location, and subjected to genomic sequencing. Sequence data is analyzed using the three dimensional coordinate system, so that the original tissue is thereby analyzed as a three dimensional system volume. At the same time, alternate tissue sections (or the same sections from which samples have been extracted with sample punches) can be subjected to staining and imaging to do histochemical analysis.
A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical laboratory services for tissue sectioning, collection and preparation; preparation of tissue sample slides for research and testing for scientific and medical research purposes; pathology and histology laboratory services; tissue testing services for scientific and medical research purposes; tissue analysis services for scientific and medical research purposes Medical testing of tissue samples for diagnostic purposes; medical testing of tissue samples for treatment purposes; medical analysis services including tissue preparation and analysis for diagnostic, pathology, histology and treatment purposes; tissue diagnostic testing services for medical purposes; tissue testing services for medical purposes; tissue analysis services for medical purposes; tissue imaging and data storage for diagnostic services and analysis for medical purposes
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Scientific research apparatus, namely, automated tissue sectioning apparatus, collection apparatus and preparation apparatus for research and diagnostic use for cancer testing, other tissue testing and other tissue analysis Automated apparatus for collecting and preparing tissue samples for pathology, histology or other tissue analysis for medical use; automated tissue sectioning apparatus for medical use; automated microtomy apparatus for cutting tissue samples for medical use; automated apparatus for transferring sectioned tissue samples to tape for medical use; automated apparatus for transferring tissue samples to slides for pathology, histology or other tissue analysis for medical use; automated apparatus for the preparation of tissue specimen glass slides for pathology, histology or other tissue analysis for medical use; diagnostic tissue specimen glass slides for collecting and storing tissue samples and materials for use with diagnostic glass slides for storing tissue samples; diagnostic tissue sample carrying tape for collecting and transferring multiple sectioned tissue specimens within the automated apparatus Medical laboratory services for tissue sectioning, collection and preparation; preparation of tissue sample slides for research and testing for scientific and medical research purposes; pathology and histology laboratory services; tissue testing services for scientific and medical research purposes; tissue analysis services for scientific and medical research purposes Medical testing of tissue samples for diagnostic purposes; medical testing of tissue samples for treatment purposes; medical analysis services including tissue preparation and analysis for diagnostic, pathology, histology and treatment purposes; tissue diagnostic testing services for medical purposes; tissue testing services for medical purposes; tissue analysis services for medical purposes; tissue imaging and data storage for diagnostic services and analysis for medical purposes
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific research apparatus, namely, automated tissue sectioning apparatus, collection apparatus and preparation apparatus for research and diagnostic use for cancer testing, other tissue testing or other tissue analysis Automated apparatus for collecting and preparing tissue samples for pathology, histology or other tissue analysis for medical use; automated tissue sectioning apparatus for medical use; automated microtomy apparatus for cutting tissue samples for medical use; automated apparatus for transferring sectioned tissue samples to tape for medical use; automated apparatus for transferring tissue samples to slides for pathology, histology or other tissue analysis for medical use; automated apparatus for the preparation of tissue specimen glass slides for pathology, histology or other tissue analysis for medical use; diagnostic tissue sample carrying tape for collecting and transferring multiple sectioned tissue specimens within the automated apparatus for medical use
A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
An automated tape transfer apparatus (1) including a tape feed mechanism (3) feeding a continuous length of an adhesive tape (2) through the automated tape transfer apparatus (1) and a tape applicator (7) applying the adhesive tape (2) to a cutting face (401) of a sample block (20, 402), wherein a section (600) of the sample block (20, 402) is adhered to the adhesive tape (2) after cutting of the section (600) from the sample block (20, 402). A slide station (5) transfers the cut section (600) from the adhesive tape (2) to a slide (115, 515).
An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
The invention is directed to a preserved serial set of sequential, iterative, and ordered thin sections of a specimen block, and a catalog of images taken from one or more sub-series of the set of sections and organized so as to create a three-dimensional profile of the microscopic structures of the specimen block. The serial set of sequential, iterative, and ordered thin sections are prepared from the specimen block by cutting and imaging thin sections of that specimen block so that the thin sections remain strictly in the sequential, iterative, order in which they are cut from the specimen block. A spatial index is created from the cataloged three-dimensional images which is searchable by local content-based image retrieval (LCBIR). The LCBIR query is used to locate, within the three-dimensional index, microscopic structural features, thereby making that portion of the specimen available for further analysis and/or for extraction.
Three dimensional tumor volume is analyzed spatially by genomics and transcriptomics, or both. Thin sections are cut with a microtome using a tape transfer technique so that the thin tissue sections remain without any distortion or deformation, in sequence relative to their position in the original tissue, so that a three-dimensional coordinate system can be anchored to each tissue section. Small samples of tissue are extracted or punched from very precise locations in the supports using the coordinate system as a grid, with known x,y,z location, and subjected to genomic sequencing. Sequence data is analyzed using the three dimensional coordinate system, so that the original tissue is thereby analyzed as a three dimensional system volume. At the same time, alternate tissue sections (or the same sections from which samples have been extracted with sample punches) can be subjected to staining and imaging to do histochemical analysis.
A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.
