Provided herein is a particle consisting essentially of micronized ESM and having a mean particle diameter of less than 100 μm for use in promoting the healing of a chronic wound at risk of, or in which there is, (i) an inappropriate level of matrix-metalloproteinase (MMP) activity against extracellular matrix (ECM) proteins and/or peptide growth or differentiation factors, and/or (ii) an excessive inflammatory response. Further provided are pharmaceutical compositions, wound dressings and implantable medical devices including the micronized ESM-containing particles for use in said treatments. Still further provided are methods for manufacturing the micronized ESM-containing particles and the compositions, dressings and implantable medical devices including the same.
A61L 15/40 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof
A61L 15/60 - Liquid-swellable gel-forming materials, e.g. super-absorbents
A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
A61L 31/00 - Materials for other surgical articles
The invention provides a three dimensional (3D), porous, biodegradable and biocompatible tissue engineering scaffold, wherein at least 25% w/w of the scaffold is particulate egg shell membrane (ESM) distributed substantially uniformly therein and the scaffold is essentially dry. Methods for preparing the same by freeze-drying and cryogelation and the use thereof in methods of tissue engineering and to promote the healing of wounds are also provided.
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
The invention provides a dry biocompatible film comprising at least one film forming material and particulate egg shell membrane (ESM), wherein said particulate ESM is distributed substantially uniformly in and/or on the film and wherein said film, or portion thereof, disintegrates upon contact with a wound or an exudate thereof. The invention further provides methods for preparing the films of the invention and the uses thereof in methods to promote the healing of wounds.
The invention provides a particle consisting essentially of micronized ESM and having a mean particle diameter of less than 100 μm for use in promoting the healing of a chronic wound at risk of, or in which there is, (i) an inappropriate level of matrix-metalloproteinase (MMP) activity against extracellular matrix (ECM) proteins and/or peptide growth or differentiation factors, and/or (ii) an excessive inflammatory response. The invention further provides pharmaceutical compositions, wound dressings and implantable medical devices comprising the micronized ESM-containing particles for use in said treatments. The invention still further provides methods for manufacturing the micronized ESM-containing particles and the compositions, dressings and implantable medical devices comprising the same.
A61L 15/40 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof
A61L 15/60 - Liquid-swellable gel-forming materials, e.g. super-absorbents
A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
A61L 31/00 - Materials for other surgical articles
The invention provides a dry biocompatible film comprising at least one film forming material and particulate egg shell membrane (ESM), wherein said particulate ESM is distributed substantially uniformly in and/or on the film and wherein said film, or portion thereof, disintegrates upon contact with a wound or an exudate thereof. The invention further provides methods for preparing the films of the invention and the uses thereof in methods to promote the healing of wounds.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical and veterinary preparations; medical
dressings; plasters; hygienic bandages; materials for
dressing wounds; dressings for wounds; by-products of the
processing of eggs for medical purposes; lotions, creams and
gels for medical purposes; powder for use in wound healing;
food supplements for humans or animals; dietetic
preparations and foodstuffs for medical or veterinary use;
dietary fiber; dermatological and medical skin creams, skin
lotions and skin oils, all for humans or animals; chemical
preparations for medical or veterinary use; biological
preparations for medical or veterinary use; chemical
reagents for medical or veterinary use; foodstuffs for
babies.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Medical dressings; plasters; hygienic bandages; materials
for dressing wounds; dressings for wounds; by-products of
the processing of eggs for medical purposes; lotions, creams
and gels for medical purposes; powder for use in wound
healing.
The invention provides a three dimensional (3D), porous, biodegradable and biocompatible tissue engineering scaffold, wherein at least 25% w/w of the scaffold is particulate egg shell membrane (ESM) distributed substantially uniformly therein and the scaffold is essentially dry. Methods for preparing the same by freeze-drying and cryogelation and the use thereof in methods of tissue engineering and to promote the healing of wounds are also provided.
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
The invention provides a three dimensional (3D), porous, biodegradable and biocompatible tissue engineering scaffold, wherein at least 25% w/w of the scaffold is particulate egg shell membrane (ESM) distributed substantially uniformly therein and the scaffold is essentially dry. Methods for preparing the same by freeze-drying and cryogelation and the use thereof in methods of tissue engineering and to promote the healing of wounds are also provided.
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Medical dressings; plasters for medical purposes; hygienic adhesive bandages; materials for dressing wounds; dressings for wounds; by-products of the processing of eggs for medical purposes [ ; powder for use in wound healing ]
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for treating wounds; medical dressings; medical plasters; hygienic surgical bandages for skin wounds; materials for dressing wounds, namely, wound dressings; dressings for wounds; by-products of the processing of eggs for medical purposes; lotions, creams and gels for medical purposes for the skin; medicated powder for use in wound healing; food supplements for humans; dietetic foodstuffs for medical use; dermatological and medical skin creams, skin lotions and skin oils, all for humans; chemical preparations for medical use for treating wounds; biological preparations for medical use for treating wounds; chemical reagents for medical use; foodstuffs for babies
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Pharmaceutical and veterinary preparations for the treatment of wounds; medical dressings; adhesive plasters for medical purposes; hygienic adhesive bandages; bandages for dressing wounds; dressings for wounds; by-products of the processing of eggs for the treatment of wounds; lotions, creams and gels for use in wound healing; antimicrobial powder for use in wound healing; protein supplements for animals, animal feed supplements; non-medical nutritional additives for animal foodstuffs; dietary fiber as a food additive; chemical preparations for the treatment of wounds in humans and animals; biological preparations for the treatment of wounds in humans and animals; foodstuffs for babies.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Medical dressings; adhesive plasters for medical purposes; hygienic adhesive bandages; bandages for dressing wounds; dressing for wounds; by-products of the processing of eggs for the treatment of wounds; lotions, creams and gels for use in wound healing; antimicrobial powder for use in wound healing
14.
MICRONIZED EGGSHELL MEMBRANE PARTICLES AND THE USE THEREOF TO PROMOTE THE HEALING OF WOUNDS
The invention provides a particle consisting essentially of micronized ESM and having a mean particle diameter of less than 100 µm for use in promoting the healing of a chronic wound at risk of, or in which there is, (i) an inappropriate level of matrix-metalloproteinase (MMP) activity against extracellular matrix (ECM) proteins and/or peptide growth or differentiation factors, and/or (ii) an excessive inflammatory response. The invention further provides pharmaceutical compositions, wound dressings and implantable medical devices comprising the micronized ESM-containing particles for use in said treatments. The invention still further provides methods for manufacturing the micronized ESM-containing particles and the compositions, dressings and implantable medical devices comprising the same.
The invention provides a particle consisting essentially of micronized ESM and having a mean particle diameter of less than 100 µm for use in promoting the healing of a chronic wound at risk of, or in which there is, (i) an inappropriate level of matrix-metalloproteinase (MMP) activity against extracellular matrix (ECM) proteins and/or peptide growth or differentiation factors, and/or (ii) an excessive inflammatory response. The invention further provides pharmaceutical compositions, wound dressings and implantable medical devices comprising the micronized ESM-containing particles for use in said treatments. The invention still further provides methods for manufacturing the micronized ESM-containing particles and the compositions, dressings and implantable medical devices comprising the same.
The invention concerns a method of processing eggshell residues, which emanate from an egg breaking unit (1) and comprise eggshell portions as well as membrane portions. The method comprises feeding of the eggshell residues into a cyclone (5), which is driven by a process gas having a temperature of less than 85°C. In said cyclone (5) vortex processing of the eggshell residues leads to peeling of said membrane portions off of said eggshell portions, such that said eggshell portions become separated from said membrane portions. A mix mainly of process gas, vapour and droplets is released through a top outlet (6) of said cyclone (5), whereas a mixture mainly of separated eggshell portions and membrane portions is released through a bottom outlet (7) of said cyclone (5). Finally in a sorting device (8) sorting of said released mixture is performed into an eggshell portion part and a membrane portion part.
A fiber containing an eggshell membrane component. The fiber is produced by spinning using a solution containing the eggshell membrane component by employing an electrospinning method. A fiber assembly formed from the fiber obtained by employing the electrospinning method imitates a natural eggshell membrane, whereby sufficient air permeability is exhibited. Since the fiber assembly is also excellent in adherence to skin tissue of a human body and stypticity, the fiber assembly may be preferably used as a wound dressing or a cosmetic sheet.
