Abstract

Various devices and methods covering a technology for combinatorial liquid handling. At least some example embodiments of the devices may include a plurality of liquid dispensers configured to dispense drops, wherein at least a carrier drop is dispensed and sequentially collides and merges with drops dispensed from a sub-plurality of liquid dispensers, so that liquids from the sub-plurality of liquid dispensers are located in the carrier drop during flight, and a support surface being positioned so that the carrier drop lands on the support surface.

IPC Classes  ?

• B01F 33/302 - Micromixers the materials to be mixed flowing in the form of droplets
• A61J 3/00 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
• B01F 23/41 - Emulsifying
• B01F 23/411 - Emulsifying using electrical or magnetic fields, heat or vibrations
• B01F 33/301 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
• B01F 33/3031 - Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
• B01F 101/00 - Mixing characterised by the nature of the mixed materials or by the application field
• B01F 101/22 - Mixing of ingredients for pharmaceutical or medical compositions
• B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
• B29C 64/209 - HeadsNozzles
• B29K 105/00 - Condition, form or state of moulded material
• B29L 31/00 - Other particular articles
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B33Y 80/00 - Products made by additive manufacturing
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

A device for recording data in nucleic acids that includes a liquid dispenser configured to dispense a carrier drop, a drop collecting element, wherein during operation of the device the carrier drop flies from the liquid dispenser towards the drop collecting element in a trajectory, and at least two other liquid dispensers, arranged such that the carrier drop's trajectory passes by the at least two other liquid dispensers. The at least two other liquid dispensers are configured to dispense two respective drops towards the trajectory of the carrier drop in a synchronized manner, such that the carrier drop sequentially collides with the two drops. Each drop of the two drops aggregately includes a subset of components from a set of nucleic acid components, thereby the subsets of components are located in the carrier drop during flight and before the carrier drop lands on the drop collecting element.

IPC Classes  ?

• G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
• B01F 25/00 - Flow mixersMixers for falling materials, e.g. solid particles
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus

Abstract

Disclosed is a device for recording data in nucleic acids. The device comprises a liquid dispenser configured to dispense a carrier drop, a drop collecting element, wherein during operation of the device the carrier drop flies from the liquid dispenser towards the drop collecting element in a trajectory, and at least two other liquid dispensers, arranged such that the carrier drop's trajectory passes by the at least two other liquid dispensers. The at least two other liquid dispensers are configured to dispense two respective drops towards the trajectory of the carrier drop in a synchronised manner, such that the carrier drop sequentially collides with the two drops. Each drop of the two drops aggregately comprises a subset of components from a set of nucleic acid components, thereby the subsets of components are located in the carrier drop during flight and before the carrier drop lands on the drop collecting element.

IPC Classes  ?

• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

In the present disclosure, various devices and methods covering a technology for combinatorial liquid handling are disclosed. At least some example embodiments of the devices disclosed herein may include a plurality of liquid dispensers configured to dispense drops, wherein at least a carrier drop is dispensed and sequentially collides and merges with drops dispensed from a sub-plurality of liquid dispensers, so that liquids from the sub-plurality of liquid dispensers are located in the carrier drop during flight, and a support surface being positioned so that the carrier drop lands on the support surface.

IPC Classes  ?

• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B01F 25/23 - Mixing by intersecting jets
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

A method of storing information in nucleic acid includes processing units of information into permutation numbers by a reversible algorithm, providing a library of n distinct oligonucleotide strings of predetermined length in a fixed order, n being a positive integer and each distinct oligonucleotide string associated with a distinct index indicating the ordinal position, assembling distinct oligonucleotide strings to create strands comprising at least two oligonucleotide strings, each oligonucleotide string's ordinal position matching with a permutation number, each strand including at least a data bearing part and a semantic part, and the semantic part to allocate orientation and/or order to a strand.

IPC Classes  ?

• G16B 50/20 - Heterogeneous data integration
• G06N 3/12 - Computing arrangements based on biological models using genetic models
• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using elements simulating biological cells, e.g. neuron

Abstract

Method of storing information in nucleic acid is disclosed which comprises processing units of information into permutation numbers by a reversible algorithm, providing a library of n distinct oligonucleotide strings of predetermined length in a fixed order, wherein n is a positive integer, wherein each distinct oligonucleotide string is associated with a distinct index indicating the ordinal position, assembling distinct oligonucleotide strings to create strands comprising at least two oligonucleotide strings, wherein each oligonucleotide string's ordinal position matches with a permutation number obtained in step a), wherein each strand comprises at least a data bearing part and a semantic part, wherein the semantic part is to allocate orientation and/or order to a strand.

IPC Classes  ?

• G16B 50/20 - Heterogeneous data integration

Abstract

The present invention refers to a system for detecting and tracking of a sample input in a sample receptacle, particularly for detecting and tracking of the input of the extremely small fluid volumes into micro-plates, preferably when performing laboratory analysis. The system according to the invention comprises a processing unit (2) attached by means of a data line (3) to a tracking device (4) arranged in the area under a micro-plate (1), and a detecting device (5) for detectIon of the fluid input.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
• B01L 9/00 - Supporting devicesHolding devices