Disclosed are systems and methods for the cryopreservation of biological samples. The system including a mixing device configured hold the biological sample and a cryoprotectant and mix the contents therein. The mixing device can include a basket that moves within mixing device to ensure efficient mixing of the cryoprotectant. The system further includes a cooling device to cool the sample and cryoprotectant. The method includes placing a biological sample within the basket, such that the container is subject to cooling by the cooling device. Subsequently, cryoprotectant is added while the cooling device cools the biological sample. During this process the basket is moved within the container.
The present invention relates to a sample processing bag (10) for use in a tissue disaggregation apparatus (200) for disaggregation of tissue therein. A clamp assembly 60 comprising a base support (70) and a clamp mechanism (72) is configured to retain the sample processing bag (10) adjacent to the base support (70) during a tissue disaggregation operation such that action of the tissue disaggregation apparatus 200 acts on the sample processing bag (10) to disaggregate any tissue therein.
The present invention relates to a shipping container for cryopreserved biological samples in which a cryopreserved sample can be maintained on arrival at its destination for a period of time, for example several months.
F25B 9/14 - Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point characterised by the cycle used, e.g. Stirling cycle
A01N 1/145 - Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths
F25D 3/10 - Devices using other cold materialsDevices using cold-storage bodies using liquefied gases, e.g. liquid air
F25D 19/00 - Arrangement or mounting of refrigeration units with respect to devices
F25D 3/14 - Devices using other cold materialsDevices using cold-storage bodies using solidified gases, e.g. carbon-dioxide snow portable, i.e. adapted to be carried personally
4.
BUNG FOR INSULATING A CONTAINER AND COOLING METHODS
Disclosed herein is a device in the form of a bung for insulating a container interior from the ambient environment, the bung comprising: a plurality of insulating segments; and one or more barriers for reflecting infrared radiation. Disclosed is: a method of preparing a shipping system for retaining a cryopreserved sample, the method comprising: loading a cryopreserved sample into a container such as a vacuum flask; and fitting the bung to the container to insulate the container interior from the ambient environment, and a method of cooling a container, such as a vacuum flask, for retaining cryopreserved samples to a desired temperature, the method comprising: cooling the container interior by pouring a cryogenic fluid such as liquid nitrogen into the container; and emptying the cryogenic fluid from the container, once the cooling has at least partially taken place.
B65D 81/38 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
B65D 39/00 - Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
Disclosed herein is a device in the form of a bung for insulating a container interior from the ambient environment, the bung comprising: a plurality of insulating segments; and one or more barriers for reflecting infrared radiation. Disclosed is: a method of preparing a shipping system for retaining a cryopreserved sample, the method comprising: loading a cryopreserved sample into a container such as a vacuum flask; and fitting the bung to the container to insulate the container interior from the ambient environment, and a method of cooling a container, such as a vacuum flask, for retaining cryopreserved samples to a desired temperature, the method comprising: cooling the container interior by pouring a cryogenic fluid such as liquid nitrogen into the container; and emptying the cryogenic fluid from the container, once the cooling has at least partially taken place.
A47J 41/02 - Vacuum-jacket vessels, e.g. vacuum bottles
F25D 17/04 - Arrangements for circulating cooling fluidsArrangements for circulating gas, e.g. air, within refrigerated spaces for circulating gas, e.g. by natural convection
Disclosed is a device (100, 200) for the disaggregation of tissue samples into individual cells or cell clumps in a closed flexible tissue sample bag (10); the device including two or more resilient feet (134/136, 234/236) which tread sequentially a tissue sample bag receiving area (148,248). Also disclosed is a heat transfer plate (150, 250) for transferring heat energy to or from the area (148,248), the plate having one plate surface (151,251) adjacent the area (148,248) and an opposing surface (152,252) exposed to external thermal influence which faces away from the area (148,248). Further disclosed is a tissue sample receiving bag (10) comprising one or more flexible plastics cavity (12) formed from two layers of the plastics sealed around their edges to form a generally rectilinear periphery with the cavity or cavities (12) within the periphery, and at one side of the periphery is formed one or more sealable access ports (16). One part of the bag is left unsealed to provide a tissue sample receiving opening.
A device and a method for mixing a fluid in a specimen bag is provided herein. In one embodiment, the device includes a mechanism for creating a first vortex and a second vortex. The first vortex is on a first side of a bag containing the fluid, and the second vortex is on a second side of the bag. The mechanism includes a first inflatable airbag and a second inflatable airbag. The first inflatable airbag is configured to create the first vortex when inflated and the second inflatable airbag is deflated. The second inflatable airbag is configured to create the second vortex when inflated and the first inflatable airbag is deflated.
B01F 25/42 - Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
B01F 31/55 - Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being contained in a flexible bag submitted to periodical deformation
B01F 35/513 - Flexible receptacles, e.g. bags supported by rigid containers
Medical apparatus and equipment for the collection,
processing, analysis and preservation of biological samples
such as blood and cellular products; disposable medical
containers for the collection and preservation and transport
of blood and cellular products; kits comprising disposable
bags for the collection, processing, analysis and
preservation of biological samples such as blood and
cellular products; bags and boxes for collecting and
preserving biological samples such as blood and cellular
products.
Medical apparatus and equipment for the collection, processing, analysis and preservation of biological samples such as blood and cellular products; disposable medical containers for the collection and preservation and transport of blood and cellular products; kits comprising disposable bags for the collection, processing, analysis and preservation of biological samples such as blood and cellular products; bags and boxes for collecting and preserving biological samples such as blood and cellular products; none of the aforementioned goods consisting of apparatus, equipment or reagents used in the process of electrophoresis, mass spectrometry and/or screening of autoimmune and infectious diseases
Disclosed is a bioprocessing system comprising apparatus (200) including a centrifugal separation housing (210) having a temperature controllable compartment (215) for removably accepting a separation chamber (50), the apparatus further comprising at least one mixing station (250) for supporting one or more fluid storage vessels (10, 20, 30, 40), the station including a temperature controllable area (252) for increasing or decreasing the temperature of the contents of the or each supported vessel. The system further includes a disposable fluidic arrangement (100) including a centrifugal separation chamber (50) removably mountable within the compartment (215) and having one or more ports (52) allowing fluid ingress into, or egress out of the chamber, via the one or more ports in use, said ports being in fluid communication with one or more of said fluid storage vessels via fluid conduits (12, 22, 32, 42) and via one or more valve arrangement.
The invention discloses a sterile syringe (100) comprising a barrel (1) having internal surfaces (2), a plunger (3) movable within the barrel, a non-sliding seal (7) between the barrel and the plunger defining a sealed volume (8) and at least one filter (9) allowing only filtered gases to enter the sealed volume such that the syringe maintains its sterility even after several uses. The filters could be positioned on different locations on the syringe like on the non-sliding seal, the barrel, the barrel flange or the plunger handle.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
An accessory for a freezing apparatus for cryogenic
preservation for scientific and laboratory purposes, namely,
an accessory used to dissociate biological tissues into
their cellular components before freezing that also will
have a consumable bag for storing and processing the tissue. An accessory for a freezing apparatus for cryogenic
preservation for medical purposes, namely, an accessory used
to dissociate biological tissues into their cellular
components before freezing that also will have a consumable
bag for storing and processing the tissue.
13.
Apparatus and methods relating to freezing at least part of a biological sample
Disclosed is a device for use in freezing at least part of a biological sample in a receptacle, e.g. a vial or a cryopreservation bag, the device comprising: a base; and a receptacle holder comprising: a first part configured to, with the receptacle held by the receptacle holder during cooling of the base using a cooler device, withdraw heat energy from a first portion of the receptacle at a first heat withdrawal rate; and a second part configured such that, with the receptacle held by the receptacle holder during cooling of the base using the cooler device, a second heat withdrawal rate of heat energy withdrawal from a second portion of the receptacle via the second part is less than the first heat withdrawal rate. A temperature gradient may be established in the sample to enable progressive solidification to occur in the sample. A receptable for use in freezing a biological sample, and a freezing method are disclosed also.
Disclosed is a computer-implemented method comprising: obtaining first data indicative of electric power supplied to a cooling apparatus during a cooling operation on a biological sample, the cooling operation having a given cooling condition; obtaining second data associated with a reference cooling condition; determining, based on the first data and the second data, whether the given cooling condition has a predetermined relationship with the reference cooling condition; and in response to a determination, by the determining, that the given cooling condition has the predetermined relationship with the reference cooling condition, outputting a control signal. The given cooling condition for the “live” data cooling operation may thus be validated against a reference cooling condition.
G05B 19/4155 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme
Containers (100) for cryopreserved biological samples (102) may include an insulated housing including a cavity (108) for containing at least one cryopreserved biological sample; and a sealed reservoir (106) at least partly surrounding the cavity, the sealed reservoir including liquified gas (120) such as liquified air, the gas being kept largely liquified by a heat transfer engine (112) such as a Stirling cryocooler. A valve (114) may be provided to function as both a pressure relief valve and an inlet valve. The inlet valve may be coupled to a sensor (122) for sensing a volume of liquified gas within the sealed reservoir. The container may further include a heat exchanger (116) coupled to the heat engine and extending into the sealed reservoir.
F17C 3/08 - Vessels not under pressure with provision for thermal insulation by vacuum spaces, e.g. Dewar flask
F25B 9/14 - Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point characterised by the cycle used, e.g. Stirling cycle
F25D 3/10 - Devices using other cold materialsDevices using cold-storage bodies using liquefied gases, e.g. liquid air
F25D 11/04 - Self-contained movable devices associated with refrigerating machinery, e.g. domestic refrigerators specially adapted for storing deep-frozen articles
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) An accessory for a freezing apparatus for cryogenic preservation for scientific and laboratory purposes, namely, a cell processor used to dissociate biological tissues into their cellular components before freezing that also will have a consumable bag for storing and processing the tissue.
(2) An accessory for a freezing apparatus for cryogenic preservation for medical purposes, namely, a cell processor used to dissociate biological tissues into their cellular components before freezing that also will have a consumable bag for storing and processing the tissue.
The present invention relates to methods of cryopreservation and compositions for use in such methods where the methods utilise non-Newtonian fluid properties of the cryopreservation medium to modulate the viscosity of that medium to deliver an improved cryopreservation process.
Disclosed is a centrifugal separation chamber (100) rotatable about an axis (AR) and having a variable volume separation space (116) therewithin and a port (102) in fluid communication with the volume for filling and emptying the volume, the chamber including a relatively rigid portion (104) proximal to the port which has walls defining a part of the volume and arranged to provide reducing dimensions of the volume toward the port, the chamber further including a flexible portion (106) distal to the port for providing said variable volume, the flexible portion including a mechanical interface (110) for transmitting movement to the flexible portion to cause said variable volume.
The present invention relates to methods and apparatus for the cryopreservation of biological samples involving a density assisted vitrification wherein a sample of biological material in a cryopreservation agent is cooled from its top surface, causing an ice layer to form thereon. As cooling continues the ice layer grows downwards through the sample to provide a cryoprotectant and biological material rich layer below the ice layer that undergoes vitrification as cooling continues to below the glass transition temperature.
The present invention relates to a system for separating biological fluids ink components that makes use of a hollow centrifugal processing chamber of variable volume. The system is a functionally closed centrifugation chamber that extracts sub-components of a biological fluid according to their density and size, such as platelets, plasma or red cells from whole blood.
A device for the processing and separation of biological fluids into components comprises a hollow centrifugal processing chamber (10) fitted with an inlet/outlet head (20) and preferably with an axially movable piston (18). The inlet/outlet head has two separate inlets/outlets, for instance an axial inlet (29) and a lateral outlet (40). The processing chamber (1) is fitted with an internal flow guide (30) enabling operation of the device in a continuous processing mode wherein biological fluid to be processed is continuously intaken by say the axial inlet (29) and at the same time processed components are continuously removed via say the lateral outlet (40). The continuous processing flow can be driven by an external peristaltic pump (59) and/or by axial displacement of a piston (18) in the chamber (10).
A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample is provided. A remote server capable of transmitting freezing profile data to one or more freezers, transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.
B01L 7/00 - Heating or cooling apparatusHeat insulating devices
H04L 67/125 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks involving control of end-device applications over a network
23.
Systems and methods for remotely monitoring the cryogenic processing of samples
A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample is provided. A remote server capable of transmitting freezing profile data to one or more freezers, transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.
B01L 7/00 - Heating or cooling apparatusHeat insulating devices
H04L 67/125 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks involving control of end-device applications over a network
24.
Systems and methods for remotely monitoring the cryogenic processing of samples
A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample is provided. A remote server capable of transmitting freezing profile data to one or more freezers, transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.
B01L 7/00 - Heating or cooling apparatusHeat insulating devices
H04L 67/125 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks involving control of end-device applications over a network
The present invention relates to a shipping container for cryopreserved biological samples in which a cryopreserved sample can be maintained on arrival at its destination for a period of time, for example several months.
F25B 9/14 - Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point characterised by the cycle used, e.g. Stirling cycle
F25D 3/10 - Devices using other cold materialsDevices using cold-storage bodies using liquefied gases, e.g. liquid air
F25D 19/00 - Arrangement or mounting of refrigeration units with respect to devices
F25D 3/14 - Devices using other cold materialsDevices using cold-storage bodies using solidified gases, e.g. carbon-dioxide snow portable, i.e. adapted to be carried personally
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
An accessory for a freezing apparatus for cryogenic preservation for scientific and laboratory purposes, namely, a cell processor used to dissociate biological tissues into their cellular components before freezing that also will have a consumable bag for storing and processing the tissue An accessory for a freezing apparatus for cryogenic preservation for medical purposes, namely, a cell processor used to dissociate biological tissues into their cellular components before freezing that also will have a consumable bag for storing and processing the tissue
Apparatus are provided for preventing the formation of ice crystals in a biological sample containing a non-Newtonian fluid as a cryopreservation medium. The apparatus may be used to prevent ice formation during cryopreservation of biological samples, or during warming of cryopreserved biological samples, by changing the viscosity of the non-Newtonian fluid. The apparatus (200) comprises a housing (202) for a container (212) containing the biological sample (214) and the non-Newtonian fluid, and a device (204) for inducing a change in viscosity of the cryopreservation medium. The change in viscosity may be increased by inducing shear thickening of the cryopreservation medium, or the change in viscosity may be decreased by inducing shear thinning of the cryopreservation medium. Possible viscosity-changing devices comprise a tapping device, a piston, a rotating device, a compression device, a sound generating device, a permanent magnet or a electromagnetic field generating device. The apparatus may further include a temperature control device.
A process for the sequential processing of opaque and transparent biological fluids such as whole blood, apheresis blood, bone marrow blood, umbilical cord blood, buffy coat or cultured cells by processing steps in a hollow cylindrical centrifugal processing chamber (300) which is part of a disposable set. At least three different procedures selected from washing, incubation, transduction, separation, density gradient separation, dilution and volume adjustment are each carried out once or repeated a number of times according to a given processing profile in the processing chamber. Each procedure involves an input into the processing chamber, an operation in the processing chamber and an output from the processing chamber by displacement of a piston (310). The at least three different procedures are sequentially chained one after the other to constitute an overall sequential operation in the processing chamber and its disposable set. A first application is incubation for binding magnetic beads with human blood cells or stem cells. A second application is transduction by which foreign genetic material is inserted into human blood cells or stem cells by a virus. A third application is reconditioning biological fluids to achieve reproducible concentration and volumes of blood cells or stem cells.
n), transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.
F25D 29/00 - Arrangement or mounting of control or safety devices
A01N 1/145 - Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths
A01N 1/148 - Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving with provisions specially adapted for transporting
A01N 1/162 - Temperature processes, e.g. following predefined temperature changes over time
B01L 7/00 - Heating or cooling apparatusHeat insulating devices
H04L 67/125 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks involving control of end-device applications over a network
Disclosed is a bioprocessing system comprising apparatus (200) including a centrifugal separation housing (210) having a temperature controllable compartment (215) for removably accepting a separation chamber (50), the apparatus further comprising at least one mixing station (250) for supporting one or more fluid storage vessels (10, 20, 30, 40), the station including a temperature controllable area (252) for increasing or decreasing the temperature of the contents of the or each supported vessel. The system further includes a disposable fluidic arrangement (100) including a centrifugal separation chamber (50) removably mountable within the compartment (215) and having one or more ports (52) allowing fluid ingress into, or egress out of the chamber, via the one or more ports in use, said ports being in fluid communication with one or more of said fluid storage vessels via fluid conduits (12,22,32,42) and via one or more valve arrangements
Disclosed is a bioprocessing system comprising apparatus (200) including a centrifugal separation housing (210) having a temperature controllable compartment (215) for removably accepting a separation chamber (50), the apparatus further comprising at least one mixing station (250) for supporting one or more fluid storage vessels (10, 20, 30, 40), the station including a temperature controllable area (252) for increasing or decreasing the temperature of the contents of the or each supported vessel. The system further includes a disposable fluidic arrangement (100) including a centrifugal separation chamber (50) removably mountable within the compartment (215) and having one or more ports (52) allowing fluid ingress into, or egress out of the chamber, via the one or more ports in use, said ports being in fluid communication with one or more of said fluid storage vessels via fluid conduits (12,22,32,42) and via one or more valve arrangements
Apparatus and equipment for the collection, processing, analysis and preservation of biological samples such as blood and cellular material; disposable containers for the collection and preservation and transport of blood; apparatus for the temperature-controlled mixing of additives with biological samples such as blood and cellular material; kits comprising disposable bags for the collection, processing, analysis and preservation of biological samples such as blood and cellular material; bags and boxes for collecting and preserving biological samples such as blood and cellular material; devices, namely tubing, valves, clips, pipe clamps, caps, brooches, clamps and accessories being part of or forming accessories for medical apparatus for the collection, processing, analysis and preservation of biological samples such as blood and cellular material.
The invention discloses a sterile syringe (100) comprising a barrel (1) having internal surfaces (2), a plunger (3) movable within the barrel, a non-sliding seal (7) between the barrel and the plunger defining a sealed volume (8) and at least one filter (9) allowing only filtered gases to enter the sealed volume such that the syringe maintains its sterility even after several uses. The filters could be positioned on different locations on the syringe like on the non-sliding seal, the barrel, the barrel flange or the plunger handle.
Disclosed is a centrifugal separation chamber (100) rotatable about an axis (AR) and having a variable volume separation space (116) therewithin and a port (102) in fluid communication with the volume for filling and emptying the volume, the chamber including a relatively rigid portion (104) proximal to the port which has walls defining a part of the volume and arranged to provide reducing dimensions of the volume toward the port, the chamber further including a flexible portion (106) distal to the port for providing said variable volume, the flexible portion including a mechanical interface (110) for transmitting movement to the flexible portion to cause said variable volume.
The present invention relates to a system for separating biological fluids into components that makes use of a hollow centrifugal processing chamber of variable volume. The system is a functionally closed centrifugation chamber that extracts sub-components of a biological fluid according to their density and size, such as platelets, plasma or red cells from whole blood.
The invention provides a method of thawing a sample comprised in a container, the method comprising the steps of: a) calculating an agitation program as a function of either or both of the sample volume and the type of the container, and the ice fraction in the sample, and optionally the thermal conductivity of the sample container; b) agitating said sample according to the program to agitate at least one region of the sample; and c) changing the agitation program applied to at least one region of the sample in response to changes in the sample volume and/or sample ice fraction. The invention further provides a method of reducing shearing to cells during a method of agitation, and methods for thawing a sample wherein a sample container is differentially heated. An apparatus for use in the methods is also provided, as is an apparatus for thawing and/or cooling a sample which comprises a resilient vessel wall.
Medical apparatus and equipment for the collection, processing, analysis and preservation of biological samples such as blood and cellular material; disposable medical containers for the collection and preservation and transport of blood; medical apparatus for the temperature-controlled mixing of additives with biological samples such as blood and cellular material; kits comprising disposable bags for the collection, processing, analysis and preservation of biological samples such as blood and cellular material; medical bags and boxes for collecting and preserving biological samples such as blood and cellular material; medical devices, namely, tubing, valves, clips, pipe clamps, caps, brooches, and clamps for the collection, processing, analysis and preservation of biological samples such as blood and cellular material
Apparatus for warming, cooling, cryoprotectant solution addition and mixing biological material such as cells, umbilical cord blood, bone marrow, peripheral blood, blood constituent, or any other blood-like material in order to cryo-prepare or thaw biological products.
Apparatus for warming, cooling, cryoprotectant solution addition and mixing biological material such as cells, umbilical cord blood, bone marrow, peripheral blood, blood constituent, or any other blood-like material in order to cryo-prepare or thaw biological products
41.
System for multi-processing and separation of biological fluids
A system for the processing and separation of biological fluids into components comprises an apparatus that cooperates with a disposable set, comprising a cabinet (100) for housing a hollow centrifugal processing chamber (20) of the disposable set. The cabinet comprises a plurality of side-by-side locations (110) for receiving a corresponding plurality of centrifugal processing chambers (20) in side-by-side spaced-apart relation. Each location comprises an individual drive means (52) for driving its centrifugal processing chamber. Remotely-actuable valves (124) associated with the disposable sets are located on the apparatus' cabinet in the proximity of said locations. Valve actuation provides a display of the state of actuation of the valves (124). Selection of this state of actuation is arranged to control connection of the centrifugal processing chamber (20) of each fitted disposable set with a flexible container (200) of the same disposable set or another container, and to control connection of the centrifugal processing chambers (20) with flexible containers of the same or other fitted disposable sets in different combinations, in particular with series and/or parallel connections.
A device for the processing and separation of biological fluids into components comprises a hollow centrifugal processing chamber (10) fitted with an inlet/outlet head (20) and preferably with an axially movable piston (18). The inlet/outlet head has two separate inlets/outlets, for instance an axial inlet (29) and a lateral outlet (40). The processing chamber (1) is fitted with an internal flow guide (30) enabling operation of the device in a continuous processing mode wherein biological fluid to be processed is continuously intaken by say the axial inlet (29) and at the same time processed components are continuously removed via say the lateral outlet (40). The continuous processing flow can be driven by an external peristaltic pump (59) and/or by axial displacement of a piston (18) in the chamber (10).
Broadly speaking, embodiments of the present technique provide apparatus for controlling ice formation, such as during the processes of cryopreservation and freeze drying. In particular, the apparatus provides a mechanism to deliver an ice nucleating material into a biological sample that is to be preserved, without allowing the ice nucleating agent to contact or contaminate the biological matter within the sample.
(1) Thawing apparatus for medical purposes, namely, medical apparatus for thawing cell therapy samples; thawing apparatus for scientific research and laboratory purposes, namely, medical laboratory research instruments for thawing cell therapy samples
(1) Freezing apparatus for medical purposes, namely, medical apparatus for controlled rate freezing cell therapy samples
(2) Freezing apparatus for scientific research and laboratory purposes, namely, laboratory controlled rate freezers for cryogenic preservation
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Thawing apparatus for scientific research and laboratory purposes, namely, medical laboratory research instruments for thawing cell therapy samples Thawing apparatus for medical purposes, namely, medical apparatus for thawing cell therapy samples
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Freezing apparatus for scientific research and laboratory purposes, namely, laboratory controlled rate freezers for cryogenic preservation Freezing apparatus for medical purposes, namely, medical apparatus for controlled rate freezing cell therapy samples
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Apparatus and equipment for the collection, processing,
analysis and preservation of biological samples such as
blood and cellular products; disposable containers for the
collection and preservation and transport of blood; kits
comprising disposable bags for the collection, processing,
analysis and preservation of biological samples such as
blood and cellular products; bags and boxes for collecting
and preserving biological samples such as blood and cellular
products; devices, namely tubing, valves, clips, pipe
clamps, caps, brooches, clamps and accessories; any of
these devices being part of or forming accessories for
medical apparatus for the collection, processing, analysis
and preservation of biological samples such as blood and
cellular products. Medical or paramedical services for the collection,
processing, analysis and preservation of biological samples
such as blood and cellular products; blood bank services;
consultancy in the field of blood transfusion technology;
clinical services in connection with treatment based on
blood components, and the saving and recovery of surgical
blood.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical apparatus and equipment for the collection, processing, analysis and preservation of biological samples such as blood and cellular products; disposable medical containers for the collection and preservation and transport of blood; kits comprising disposable bags for the collection, processing, analysis and preservation of biological samples such as blood and cellular products; bags and boxes for collecting and preserving biological samples such as blood and cellular products * ; none of the aforementioned goods consisting of apparatus, equipment or reagents used in the process of electrophoresis, mass spectrometry and/or screening of autoimmune and infectious diseases * [ Medical or paramedical services for the collection, processing, analysis and preservation of biological samples such as blood and cellular products; blood bank services; consultancy in the field of blood transfusion technology; clinical services in connection with treatment based on blood components, and the saving and recovery of surgical blood ]
52.
A DEVICE, SYSTEM AND METHOD FOR THE CONTINUOUS PROCESSING AND SEPARATION OF BIOLOGICAL FLUIDS INTO COMPONENTS
A device for the processing and separation of biological fluids into components comprises a hollow centrifugal processing chamber (10) fitted with an inlet/outlet head (20) and preferably with an axially movable piston (18). The inlet/outlet head has two separate inlets/outlets, for instance an axial inlet (29) and a lateral outlet (40). The processing chamber (1) is fitted with an internal flow guide (30) enabling operation of the device in a continuous processing mode wherein biological fluid to be processed is continuously intaken by say the axial inlet (29) and at the same time processed components are continuously removed via say the lateral outlet (40). The continuous processing flow can be driven by an external peristaltic pump (59) and/or by axial displacement of a piston (18) in the chamber (10).
A device for the processing and separation of biological fluids into components comprises a hollow centrifugal processing chamber (10) fitted with an inlet/outlet head (20) and preferably with an axially movable piston (18). The inlet/outlet head has two separate inlets/outlets, for instance an axial inlet (29) and a lateral outlet (40). The processing chamber (1) is fitted with an internal flow guide (30) enabling operation of the device in a continuous processing mode wherein biological fluid to be processed is continuously intaken by say the axial inlet (29) and at the same time processed components are continuously removed via say the lateral outlet (40). The continuous processing flow can be driven by an external peristaltic pump (59) and/or by axial displacement of a piston (18) in the chamber (10).
A process for the sequential processing of opaque and transparent biological fluids such as whole blood, apheresis blood, bone marrow blood, umbilical cord blood, buffy coat or cultured cells by processing steps in a hollow cylindrical centrifugal processing chamber (300) which is part of a disposable set. At least three different procedures selected from washing, incubation, transduction, separation, density gradient separation, dilution and volume adjustment are each carried out once or repeated a number of times according to a given processing profile in the processing chamber. Each procedure involves an input into the processing chamber, an operation in the processing chamber and an output from the processing chamber by displacement of a piston (310). The at least three different procedures are sequentially chained one after the other to constitute an overall sequential operation in the processing chamber and its disposable set. A first application is incubation for binding magnetic beads with human blood cells or stem cells. A second application is transduction by which foreign genetic material is inserted into human blood cells or stem cells by a virus. A third application is reconditioning biological fluids to achieve reproducible concentration and volumes of blood cells or stem cells.
A device and a method for mixing a fluid in a specimen bag is provided herein. In one embodiment, the device includes a mechanism for creating a first vortex and a second vortex. The first vortex is on a first side of a bag containing the fluid, and the second vortex is on a second side of the bag. The mechanism includes a first inflatable airbag and a second inflatable airbag. The first inflatable airbag is configured to create the first vortex when inflated and the second inflatable airbag is deflated. The second inflatable airbag is configured to create the second vortex when inflated and the first inflatable airbag is deflated.
A system for the processing and separation of biological fluids into components comprises an apparatus that cooperates with a disposable set, comprising a cabinet (100) for housing a hollow centrifugal processing chamber (20) of the disposable set. The cabinet comprises a plurality of side-by-side locations (110) for receiving a corresponding plurality of centrifugal processing chambers (20) in side-by-side spaced-apart relation. Each location comprises an individual drive means (52) for driving its centrifugal processing chamber. Remotely-actuable valves (124) associated with the disposable sets are located on the apparatus' cabinet in the proximity of said locations. Valve actuation provides a display of the state of actuation of the valves (124). Selection of this state of actuation is arranged to control connection of the centrifugal processing chamber (20) of each fitted disposable set with a flexible container (200) of the same disposable set or another container, and to control connection of the centrifugal processing chambers (20) with flexible containers of the same or other fitted disposable sets in different combinations, in particular with series and/or parallel connections.
The present invention relates to a method for freezing a water-containing quantity of a biological entity or a formulation in a vessel using a mineral nucleator, to the use of the mineral as a nucleator and to a vessel with the mineral in or on the whole or part of a surface thereof.
A device for mixing biological specimens contained in flexible storage bags (104) at controlled temperature, comprising a support (105) for supporting a storage bag containing a biological specimen to be mixed; means for imparting a displacement to a specimen in a storage bag on the support to mix the specimen; and temperature control means for maintaining the specimens at a controlled temperature during mixing. The means for imparting displacement to a specimen comprises at least one inflatable/deflatable bag (102, 103) (air bag) that when inflated contacts the surface of a part of a storage bag to progressively squeeze the storage bag and displace the contained specimen into another part of the storage bag.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Apparatus and equipment for the collection, processing,
analysis and preservation of biological samples such as
blood and cellular material; disposable containers for the
collection and preservation and transport of blood; kits
comprising disposable bags for the collection, processing,
analysis and preservation of biological samples such as
blood and cellular material; bags and boxes for collecting
and preserving biological samples such as blood and cellular
material; devices, namely tubing, valves, clips, pipe
clamps, caps, brooches, clamps and accessories; any of these
devices being part of or forming accessories for medical
apparatus for the collection, processing, analysis and
preservation of biological samples such as blood and
cellular material. Medical or paramedical services for the collection,
processing, analysis and preservation of biological samples
such as blood and cellular material; blood bank services;
technology consultancy for blood transfusion; clinical
services in connection with treatment based on blood
components, and the saving and recovery of surgical blood.
60.
Manufacture of bags for containing biological specimens
A method of manufacturing a bag (20) for the cryopreservation of thermolabile liquids. The manufacturing method is characterized by being versatile, simple and inexpensive and allows to manufacture single and multi-compartment bags without modifying the main sealing molds (31, 32). The relative size and the number of the compartments (28) can be modified without change in the molds. Only a closure sealing tool (50) must be adjusted as a function of the number of chosen compartments (28). The process is compatible with standard high frequency sealing processes. This method provides bags (20) with uniformly thick walls and with a predetermined bag volume.
06 - Common metals and ores; objects made of metal
10 - Medical apparatus and instruments
20 - Furniture and decorative products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Metal boxes for storing samples of biological fluids. Disposable kits for collecting, treating, analysing and
preserving biological samples such as blood and cellular
material; pouches and boxes for collecting and preserving
biological samples such as blood and cellular material; and
devices for linking these kits and pouches; all these goods
being part or forming accessories for medical apparatus for
collecting, treating, analysing and preserving biological
samples such as blood and cellular material. Pouches, boxes, envelopes, bags, tubing, taps, forceps, pipe
tongs, stoppers, pins, clamps and accessories for linking
pouches; interconnected or interconnectable kits of pouches
for collecting and preserving biological samples; all these
products made of plastic. Services for collecting, treating, analysing and preserving
biological samples such as blood and cellular material.
62.
MANUFACTURE OF BAGS FOR CONTAINING BIOLOGICAL SPECIMENS
A method of manufacturing a bag (20) for the cryopreservation of thermolabile liquids. The manufacturing method is characterized by being versatile, simple and inexpensive and allows to manufacture single and multi-compartment bags without modifying the main sealing molds (31, 32). The relative size and the number of the compartments (28) can be modified without change in the molds. Only a closure sealing tool (50) must be adjusted as a function of the number of chosen compartments (28). The process is compatible with standard high frequency sealing processes. This method provides bags (20) with uniformly thick walls and with a predetermined bag volume.
B29C 65/02 - Joining of preformed partsApparatus therefor by heating, with or without pressure
B29C 65/04 - Dielectric heating, e.g. high-frequency welding
B65D 75/58 - Opening or contents-removing devices added or incorporated during package manufacture
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
06 - Common metals and ores; objects made of metal
10 - Medical apparatus and instruments
20 - Furniture and decorative products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
[ Metal boxes for storing samples of biological fluids ] Medical apparatus accessories, namely, disposable sets of interconnected medical containers and interconnectable medical containers for use in collecting, treating, analyzing and preserving biological samples such as blood and cellular material; medical apparatus accessories, namely, pouches and boxes specially designed for collecting and preserving biological samples such as blood and cellular material; medical apparatus accessories, namely, tubing, taps, clamps, stoppers and plugs, for interconnecting of and/or for fitting onto the aforementioned disposable sets of interconnectable medical containers and pouches for collecting and preserving biological samples such as blood and cellular material Plastic boxes, interconnected or interconnectable plastics sets of plastic pouches for collecting and preserving biological samples and fittings therefor, namely, plastic clamps, plastic stoppers, plastic tubing, plastic plugs [ Services for collecting, treating, analysing and preserving biological samples such as blood and cellular material, namely, collection and preservation of human blood and other cellular material for medical purposes including medical testing and for preservation of the collected blood or other cellular materials in view of later testing, analysis or use ]
Medical apparatus for collecting, processing and testing blood and other biological, cellular products; medical equipment comprising disposable sets of interconnected medical containers and interconnectable medical containers and fittings therefor, the disposable sets consitututing accessories for use with apparatus for collecting, processing and storing blood, biological and cellular products Disposable sets of non-metal, interconnected medical containers and non-metal, interconnectable medical containers and fittings therefore, for use in collecting, processing and storing blood, biological and cellular products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Apparatus, equipment and disposable sets for collecting, processing and testing blood and cellular products. Services for collecting, processing and testing blood and cellular products.
