The present disclosure relates to coatings, formulations and coating compositions, methods for using the coatings and coating compositions, and methods for applying the coatings to substrates or articles. The coatings disclosed herein are long-lasting, and are suitable for application to a wide variety of substrates or articles, which may include substrates or articles formed from natural and/or artificial materials, including plastic, metal, textiles and/or other artificial materials, and also to living substrates.
A01N 47/28 - Ureas or thioureas containing the groups N—CO—N or N—CS—N
A01N 47/40 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
The present application discloses an anti-microbial coating containing an alkyl urea polyalkylene imine polymer and an anionic polymer. The alkyl urea polyalkylene imine polymer is a polyalkylene imine polymer having at least one alkyl group attached to the polyalkylene imine polymer backbone by way of at least one urea linkage that includes a nitrogen heteroatom on the polyalkylene imine polymer backbone. The anti-microbial coating does not contain heparin or a polymer comprising heparin.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
06 - Common metals and ores; objects made of metal
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
11 - Environmental control apparatus
19 - Non-metallic building materials
20 - Furniture and decorative products
24 - Textiles and textile goods
27 - Floor and wall coverings
Goods & Services
Silica for absorbing moisture. Medical, surgical and veterinary dressings, and plasters;
wound dressings; swabs for medical, surgical and veterinary
use. Walls of metal; metal doors; metal handles; metallic door
hardware; metal door handles; metal door knobs; metal
floors; parts and fittings for all the aforementioned goods. Scientific laboratory equipment and apparatus; parts and
fittings for all the aforementioned goods; contact lenses. Medical apparatus, instruments and devices; diagnostic and
monitoring equipment for medical use; medical imaging
apparatus; scanners for medical use; surgical and wound
treating apparatus, instruments and devices; neurovascular
apparatus, instruments and devices; ocular apparatus,
instruments and devices; genito-urinary apparatus,
instruments and devices; medical implants; artificial
surgical implants; sexual activity devices; incontinence
devices; catheters; venous catheters; catheters for
urological purposes; menstrual cups; face masks for medical
use; protective clothing for medical purposes; gowns for
medical or surgical use; medical furniture and bedding;
parts and fittings for all the aforementioned goods. Ventilation installations and apparatus; HVAC systems; parts
and fittings for all the aforementioned goods. Walls (non-metallic); non-metal doors; non-metal floors;
parts and fittings for all the aforementioned goods. Small items of non-metallic hardware; non-metallic door
hardware; non-metallic window hardware; non-metal door
handles; non-metal doorknobs; non-metal handles for
furniture; parts and fittings for all the aforementioned
goods. Textiles; door curtains; curtains and lace curtains of
textile or plastic; bed linen. Floor coverings; carpets, rugs and mats; wall and ceiling
coverings.
Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
06 - Common metals and ores; objects made of metal
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
11 - Environmental control apparatus
19 - Non-metallic building materials
20 - Furniture and decorative products
24 - Textiles and textile goods
27 - Floor and wall coverings
Goods & Services
(1) Silica for absorbing moisture.
(2) Medical, surgical and veterinary dressings, and plasters; wound dressings; swabs for medical, surgical and veterinary use.
(3) Walls of metal; metal doors; metal handles; metallic door hardware; metal door handles; metal door knobs; metal floors; parts and fittings for all the aforementioned goods.
(4) Scientific laboratory equipment and apparatus; parts and fittings for all the aforementioned goods; contact lenses.
(5) Medical apparatus, instruments and devices; diagnostic and monitoring equipment for medical use; medical imaging apparatus; scanners for medical use; surgical and wound treating apparatus, instruments and devices; neurovascular apparatus, instruments and devices; ocular apparatus, instruments and devices; genito-urinary apparatus, instruments and devices; medical implants; artificial surgical implants; sexual activity devices; incontinence devices; catheters; venous catheters; catheters for urological purposes; menstrual cups; face masks for medical use; protective clothing for medical purposes; gowns for medical or surgical use; medical furniture and bedding; parts and fittings for all the aforementioned goods.
(6) Ventilation installations and apparatus; HVAC systems; parts and fittings for all the aforementioned goods.
(7) Walls (non-metallic); non-metal doors; non-metal floors; parts and fittings for all the aforementioned goods.
(8) Small items of non-metallic hardware; non-metallic door hardware; non-metallic window hardware; non-metal door handles; non-metal doorknobs; non-metal handles for furniture; parts and fittings for all the aforementioned goods.
(9) Textiles; door curtains; curtains and lace curtains of textile or plastic; bed linen.
(10) Floor coverings; carpets, rugs and mats; wall and ceiling coverings.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
06 - Common metals and ores; objects made of metal
27 - Floor and wall coverings
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
11 - Environmental control apparatus
19 - Non-metallic building materials
20 - Furniture and decorative products
24 - Textiles and textile goods
Goods & Services
Silica gel for absorbing moisture Medical, surgical and veterinary dressings and plasters; wound dressings; swabs for medical, surgical and veterinary use Walls of metal, namely, metal wallboards, metal wall tiles, prefabricated metal walls, wall plugs of metal, wall platings of metal, wall panels of metal; metal doors; metal handles, namely, door handles of metal, metal handles for drawers, metal handles for cabinets; metallic door hardware, namely, door knobs, doorknockers, door latches, door stops, door pulls, door hinges; metal door handles; metal door knobs; metal floors; replacement parts and fittings for all the aforementioned goods Floor coverings, namely, textile floor runners, textile floor mats, textile floor rugs, carpet tiles, carpet underlay, carpet inlays; carpets, rugs and floor mats of textile; wall coverings and ceiling coverings of textile; non-textile wall coverings and non-textile ceiling coverings of plastic; wall coverings and ceiling coverings of vinyl; wall coverings and ceiling coverings of plastic; wall coverings and ceiling coverings of cloth; wall coverings and ceiling coverings of paper; wall coverings and ceiling coverings of cork Scientific laboratory equipment and apparatus, namely, laboratory glassware, laboratory furniture, laboratory photochemical reactors, liquid chromatography apparatus for laboratory use, ovens for laboratory use, laboratory trays, laminar flow cabinets for laboratory use, pipette tips for laboratory use, fermenter apparatus for laboratory use, laboratory devices for detecting genetic sequences, laboratory centrifuges, laboratory filters, laboratory chemical reactors, gas chromatography apparatus for laboratory use, electrolysis apparatus for laboratory use, glass stirrers for laboratory use, sterile sampling bags for laboratory use, three-neck flasks for laboratory use, disposable dispenser syringes for laboratory use, hydrogen generators for laboratory use, aspirators for laboratory use, filters for blood and blood components for laboratory use, gloves for laboratory purposes, laminar flow biological safety cabinet hoods for laboratory use, incubators for laboratory use, glass driers for laboratory purposes, cupels for laboratory purposes, crucibles for laboratory purposes, electronic sliding callipers, laboratory cages for animals, laboratory swabs, laboratory microarrays, laboratory microscope slides, petri dishes used in laboratory research, laboratory countertops, electrodes for laboratory research; replacement parts and fittings for all the aforementioned goods; contact lenses Medical apparatus, instruments and devices, namely, medical ventilators, medical balloons, medical syringes, medical spittoons, medical electrodes, medical introducers, medical stents, medical stretchers, medical scissors, medical endoscopes, medical guidewires, medical walkers, medical imaging transducers, medical radiation apparatus, medical examination lamps, medical imaging processors, medical screw connections, medical skin abraders, medical procedure chairs, medical procedure tables, medical x-ray film, medical intubation equipment, medical cutting devices, medical exam tables, medical specimen cups, medical lancing devices, medical ankle braces, medical hearing instruments, spatulas for medical use, medical catheters, medical laparoscopes, probes for medical purposes, needles for medical purposes, bags for medical waste, nebulizers for medical purposes, thermometers for medical purposes, syringes for medical purposes, audiometers for medical purposes, cryoprobes for medical use, electrophoresis apparatus for medical purposes, medical devices for placing and securing catheters; diagnostic and monitoring equipment for medical use, namely, medical imaging apparatus, ultrasound diagnostic apparatus, nuclear medicine diagnostic imaging apparatus, percussion hammers for diagnostic purposes, medical measuring apparatus for measuring the elasticity and plasticity of skin for medical diagnostic use, diagnostic penlights for medical purposes, hematology analysers for medical diagnostic purposes, flow cytometers for medical diagnostic uses, medical diagnostic apparatus for diagnostic testing of cells, biological tissues, and cancer cells, sample preparation device for medical diagnostic uses, blood pressure and diabetic diagnostic medical devices, orthopedic devices for diagnostic use, medical diagnostic apparatus for testing for viruses, diagnostic testing apparatus for the detection of periodontal disease, medical diagnostic apparatus for testing DNA and RNA samples, medical diagnostic instruments for the analysis of body fluids, immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels, medical diagnostic apparatus for analysis and measuring of electrolytes in the body, electroencephalography (EEG) helmets for monitoring and measuring brain activity for medical diagnostic purposes, medical instrument for cardiovascular diagnostics, breath gas analysers for medical diagnostics, medical apparatus and instruments for use in positron emission tomography (PET) imaging used to monitor brain, heart and metabolic functions, respiration monitors, body composition monitors, body fat monitors, blood pressure monitors, pulse rate monitors, blood oxygen monitors, electronic temperature monitors for medical use, medical apparatus for monitoring blood glucose levels; fetal and maternal vital sign and physical distress monitors; medical imaging apparatus; surgical and wound treating apparatus, instruments and devices, namely, surgical devices and instruments, wound drainage and irrigation apparatus; neurovascular apparatus, instruments and devices, namely, coatings sold as an integral part of medical stents and other implantable medical devices; neurovascular apparatus, instruments and devices, namely, minimally invasive neurovascular devices for the treatment of neurological conditions; ocular apparatus, instruments and devices, namely, ocular speculums, ocular implants made of artificial materials, intra-ocular lenses; genito-urinary apparatus, instruments and devices, namely, urological imaging systems, gynecological medical instruments for examining women's reproductive organs, intra-uterine contraceptive devices; medical implants made of artificial materials; medical implants comprising natural, non-living materials; surgical implants comprised primarily of artificial material and also incorporating processed animal tissue for use in plastic reconstructive surgery, and repair, reinforcement or buttressing of soft tissue; surgical implants comprised of artificial materials; incontinence devices, namely, pelvic floor exercisers for use to treat symptoms of urinary incontinence for therapeutic purposes; catheters; venous catheters; catheters for urological purposes; menstrual cups; protective face masks for medical use; protective clothing for medical purposes, namely, clothing especially for operating rooms; protective clothing for medical purposes, namely, medical gloves; gowns for medical or surgical use; medical furniture and bedding, namely, furniture especially made for medical purposes, therapeutic mattresses, therapeutic beds, therapeutic seats, therapeutic cushions, incontinence sheets, and medical table sheets for examining tables and operating tables, surgical sterile sheets, draw-sheets for sick beds; replacement parts and fittings for all the aforementioned goods Ventilation installations and apparatus, namely, ventilation hoods, laboratory ventilation hoods, air impellers for ventilation, ventilation units for commercial food preparation and food serving, ventilation louvers, ventilation exhaust fans, ventilating fans for commercial and industrial use, ventilating, high-velocity fixed exhaust fans for commercial and agricultural use; replacement parts and fittings for all the aforementioned goods Non-metallic walls, namely, wall stone, wall boards, non-metal wall tiles, wall panels not of metal, pre-fabricated non-metal walls; non-metal doors; replacement parts and fittings for all the aforementioned goods Small items of non-metallic hardware, namely, non-metallic locks, non-metallic door keys, non-metallic door fittings, non-metallic window fittings, non-metallic furniture fittings, non-metallic gate latches, non-metal gate stops, non-metallic gate handles, valves of plastic being other than machine parts, non-metal valves for containers, non-metal threaded fasteners, non-metallic door fasteners, non-metallic bottle fasteners, non-metal sash fasteners for windows, non-metal hooks, non-metal fasteners in the nature of bolts, nails, rivets, screws, non-metal nuts, pulleys and springs; non-metallic door hardware, namely, door bolts, door fittings, door latches, door keys, door knockers, door pulls, door handles, door fasteners, non-electric door bells, non-electric door springs, door stops not of rubber, door guards, door clasps; non-metallic window hardware, namely, window openers and closers being non-metal window cranks, decorative window finials, window pulleys, window fasteners, window stops, window openers and closers being non-metal screw jacks, window keys, window guards, window clasps, sash fasteners for windows; non-metal door handles; non-metal doorknobs; non-metal cabinet, door and drawer handles for furniture; replacement parts and fittings for all the aforementioned goods Textiles, namely, non-woven textile fabrics, waterproof textile fabrics, adhesive labels of textile, textile wall hangings, textile fabrics for use in making household furnishing and beddings, textile fabrics for the manufacture of clothing, textile fabrics for home and commercial interiors, textile handkerchiefs, textile towels, textile place mats, textile tablecloths, textile serviettes, textile coasters, textile banners, textile labels, curtains of textile; door curtains; curtains and lace curtains of textile or plastic
The present disclosure relates to coatings, formulations and coating compositions, methods for using the coatings and coating compositions, and methods for applying the coatings to substrates or articles. The coatings disclosed herein are long-lasting, and are suitable for application to a wide variety of substrates or articles, which may include substrates or articles formed from natural and/or artificial materials, including plastic, metal, textiles and/or other artificial materials, and also to living substrates.
A method of making a coating solution includes the steps of polymerising an initial monomer feed comprising an N-vinyl pyrrolidone and an acrylate, preferably methacrylate, salt in water to synthesise a copolymer thereof, acidifying the resulting copolymer-water mixture to give free carboxylic acid groups along the copolymer backbone, diluting the aqueous solution down with alcohol, and adding a cross-linking agent which is capable of reacting with the carboxylic acid groups and curing the copolymer at a later stage after the coating solution has been applied to a substrate and the copolymer coated thereon. Also disclosed are a coating solution in storage, a method of coating a substrate which is on, or is part of, a medical device or other article, a substrate, article or medical device having a coating so applied, and a coated medical device packaged in a hydration solution. The aqueous-alcoholic coating solution may be stored for an extended period, suitably for at least one month and desirably for substantially longer, without deteriorating.
C10N 40/00 - Specified use or application for which the lubricating composition is intended
C10N 50/02 - Form in which the lubricant is applied to the material being lubricated dissolved or suspended in a carrier which subsequently evaporates to leave a lubricant coating
C10N 50/08 - Form in which the lubricant is applied to the material being lubricated solid
B05D 1/18 - Processes for applying liquids or other fluent materials performed by dipping
B05D 3/06 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
C08F 222/02 - AcidsMetal salts or ammonium salts thereof
C08F 230/02 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
C08F 220/28 - Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
C09D 133/14 - Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
C08F 130/02 - Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
C08F 122/02 - AcidsMetal salts or ammonium salts thereof
C08F 30/02 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
C08F 8/40 - Introducing phosphorus atoms or phosphorus-containing groups
C08F 8/30 - Introducing nitrogen atoms or nitrogen-containing groups
C08F 16/14 - Monomers containing only one unsaturated aliphatic radical
C08F 216/14 - Monomers containing only one unsaturated aliphatic radical
C08F 116/14 - Monomers containing only one unsaturated aliphatic radical
11.
COATING SOLUTIONS, COATINGS FORMED THEREFROM, AND COATED MEDICAL DEVICES
A method of making a coating solution includes the steps of polymerising an initial monomer feed comprising an N-vinyl pyrrolidone and an acrylate, preferably methacrylate, salt in water to synthesise a copolymer thereof, acidifying the resulting copolymer-water mixture to give free carboxylic acid groups along the copolymer backbone, diluting the aqueous solution down with alcohol, and adding a cross-linking agent which is capable of reacting with the carboxylic acid groups and curing the copolymer at a later stage after the coating solution has been applied to a substrate and the copolymer coated thereon. Also disclosed are a coating solution in storage, a method of coating a substrate which is on, or is part of, a medical device or other article, a substrate, article or medical device having a coating so applied, and a coated medical device packaged in a hydration solution. The aqueous-alcoholic coating solution may be stored for an extended period, suitably for at least one month and desirably for substantially longer, without deteriorating.
Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.
C08F 130/02 - Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
A61L 29/14 - Materials characterised by their function or physical properties
A61L 29/16 - Biologically active materials, e.g. therapeutic substances
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
C08F 230/02 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
C07F 9/06 - Phosphorus compounds without P—C bonds
C08F 122/02 - AcidsMetal salts or ammonium salts thereof
C08F 30/02 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibiiity, hydrophihcity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform
C08F 30/02 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
Substrates may be coated with copolymers of N-vinyl pyrroiidinone and aryl ketones. Processes are described for making the copolymers at high molecular weight with the ketones randomly dispersed on the copolymer.
Substrates may be coated with copolymers of N-vinyl pyrrolidinone and aryl ketones. Processes are described for making the copolymers at high molecular weight with the ketones randomly dispersed on the copolymer.
There are many medical situations that require removal of fluid from a patient. There are many ways to remove the fluid but many of these situations have not been solved. Herein, inventions are disclosed that generate osmotic pressure that can be used to remove these fluids very effectively, a technique which requires no harsh suction or pumping. One embodiment involves implanting a reservoir that has a semipermeable membrane sidewall. The reservoir contains trapped osmotic solutes that can not pass out through the membrane. But fluid from the patient can flow in. The osmotic pressure from the trapped solutes in the reservoir draws fluid from the patient across the semipermeable membrane and into the device. In some versions, the membrane can be changed as desired during the lifetime of the device by pulling the membrane out through the implanted device and putting a new one back in.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
Certain embodiments include carbonate esters of rapamycin at position 42 that are synthesized by a lipase catalyzed regio-specific process. These compounds or a pharmaceutically acceptable salt thereof are useful in the treatment of organ and tissue transplant rejection, autoimmune disease, proliferative disorder, restenosis, cancer, or microbial infection.
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemicals and chemical preparations used in industry, science and medicine; chemical coating compositions for use in industry and use in medicine; chemical compounds in solution and in powder form comprising heparin and compounds derived from heparin.
21.
Polymeric network system for medical devices and methods of use
Methods of making a coating on a medical device are disclosed, including associating a composition with at least a portion of the device to form a layer. In some embodiments, a composition may include a copolymer prepared from a room temperature melt of a plurality of monomer units that comprises a first monomer unit and a second monomer unit, wherein the second monomer unit has a glass transition temperature that is at least about 30 degrees Centigrade higher than the glass transition temperature of the first monomer unit, with a glass transition temperature of a monomer unit being defined as a glass transition temperature of a homopolymer of that monomer unit.
B32B 7/02 - Physical, chemical or physicochemical properties
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
A wound closure apparatus is provided which utilizes blood fluid by activating the clotting cascade of blood fluid outside the body within a substantially enclosed sterile container then introducing, the blood fluid to the wound site to complete clotting. An apparatus for providing ways of inhibiting anticoagulating agents, and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with, and/or associated with preferred procedures are also disclosed. The invention provides a clotting cascade initiation apparatus (1) including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources can be received, and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments, the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.
B32B 9/00 - Layered products essentially comprising a particular substance not covered by groups
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
A61D 1/00 - Surgical instruments for veterinary use
23.
ACIDIFIED AQUEOUS-ALCOHOLIC COPOLYMER COATING SOLUTIONS, COATINGS FORMED THEREFROM, AND COATED MEDICAL DEVICES
A method of making a coating solution includes the steps of polymerising an initial monomer feed comprising an N-vinyl pyrrolidone and an acrylate, preferably methacrylate, salt in water to synthesise a copolymer thereof, acidifying the resulting copolymer-water mixture to give free carboxylic acid groups along the copolymer backbone, diluting the aqueous solution down with alcohol, and adding a cross-linking agent which is capable of reacting with the carboxylic acid groups and curing the copolymer at a later stage after the coating solution has been applied to a substrate and the copolymer coated thereon. Also disclosed are a coating solution in storage, a method of coating a substrate which is on, or is part of, a medical device or other article, a substrate, article or medical device having a coating so applied, and a coated medical device packaged in a hydration solution. The aqueous-alcoholic coating solution may be stored for an extended period, suitably for at least one month and desirably for substantially longer, without deteriorating.
The disclosure relates to the technical field of polymers and polymer coatings, including coatings for medical devices. Disclosed herein are anti-thrombogenic polymers, methods for making anti-thrombogenic polymers, and polymeric coatings and coating formulations comprising anti-thrombogenic polymers. The anti-thrombogenic polymers can be utilised as disclosed herein for coating substrates, including medical devices. The anti- thrombogenic polymers and coatings disclosed herein can be useful for reducing the susceptibility of substrates, including medical devices, to platelet adhesion; and/or for preventing clot formation.
The present disclosure relates to coatings, formulations and coating compositions, methods for using the coatings and coating compositions, and methods for applying the coatings to substrates or articles. The coatings disclosed herein are long-lasting, and are suitable for application to a wide variety of substrates or articles, which may include substrates or articles formed from natural and/or artificial materials, including plastic, metal, textiles and/or other artificial materials, and also to living substrates.
Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.
Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.
C09D 151/08 - Coating compositions based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCoating compositions based on derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibiiity, hydrophihcity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform
C08F 30/02 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
Substrates may be coated with copolymers of N-vinyl pyrrolidinone and aryl ketones. Processes are described for making the copolymers at high molecular weight with the ketones randomly dispersed on the copolymer.
