Embodiments disclosed herein relate to methods and systems for determining thermal properties of materials by using frequency modulated pump light intensity to cyclically heat a sample, and using probe light to induce reflected light from reflective materials on the surface of the material during the cyclic heating. The pump and probe light may be emitted onto a plurality of locations on a material sample simultaneously. The methods and systems utilize the phase delay between the frequency modulated pump light and the corresponding reflected light to determine the thermal properties of the material at a plurality of the locations on the material sample simultaneously.
Disclosed herein are acid addition salts of cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salts may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering acid addition salts of CSAs.
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
Disclosed is a container that has a base, a body, and a crown. The base includes a base fold. The body is circumferentially connected to the base and includes at least one face section and at least one fold section. The crown is circumferentially connected to the base and includes at least one face section and at least one fold section.
B65D 5/20 - Rigid or semi-rigid containers of polygonal cross-section, e.g. boxes, cartons or trays, formed by folding or erecting one or more blanks made of paper by folding-up portions connected to a central panel from all sides to form a container body, e.g. of tray-like form
Various technologies are described herein pertaining to laser ablation of material from a workpiece. An ablation system includes a laser, a focusing system, and a computing device configured to control operation of the laser and the focusing system. The laser emits light that is received by the focusing system. The computing device controls operation of the laser and/or the focusing system such that the focusing system focuses the light emitted by the laser to a focal spot on a surface of a workpiece. The focused light causes ablation of the workpiece at the focal spot.
A writing device is provided which includes one or more emitters disposed over a tape. The writing device further includes a controller. The controller controls the emitters and instructs the emitters to write one or more pixels of information on the tape.
Disclosed is A dynamic insulation system that includes a base, one or more slats, a cap, and an inflator. The base is attached to one end of the one or more slats. The cap is attached to the second end of the one or more slats.
E04B 1/76 - Heat, sound or noise insulation, absorption, or reflectionOther building methods affording favourable thermal or acoustical conditions, e.g. accumulating of heat within walls specifically with respect to heat only
Systems and methods of providing an ingestible medical capsule (a capsule) are described. In some implementations, the capsule is configured to measure a distance traveled (by the capsule) through a gastrointestinal tract of a subject. In some cases, the capsule includes an anchor configured to associate with a portion of a gastrointestinal tract of the subject. In some iterations, the capsule includes a capsule body coupled to the anchor via a strand. In some cases, the capsule body is configured to travel a distance away from the anchor along the gastrointestinal tract of the subject and to measure the distance using the strand as a reference. Additional implementations are described.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, conducting classes, conferences, and workshops in the field of social impact, social entrepreneurship, humanitarian work, business development and distribution of educational materials in connection therewith
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (USA)
BRIGHAM YOUNG UNIVERSITY (USA)
Inventor
Mckinley, Finnegan
Aloysius, John
Brau, Rebekah
Abstract
The present disclosure relates to systems and methods for collaborative human-machine learning for demand planning. The method includes receiving a forecast for the demand planning from a machine, receiving an indication of a particular event using private information from a user, estimating an effect of the particular event, receiving lagged demand, and adjusting the forecast for the demand planning using the estimated effect of the particular event and the lagged demand.
Disclosed is storage device implemented as an optical tape and having layers. A substrate layer provides resilience to the storage device while a recording stack layer is capable of being inscribed with human-readable information. An optional lubricant layer reduces strain on the storage device as it is both inscribed and read. An optical tape records human-readable information in a small physical area and in a durable medium.
G11B 7/256 - Record carriers characterised by the selection of the material of layers other than recording layers of layers improving adhesion between layers
G11B 7/003 - Recording, reproducing or erasing systems characterised by the shape of the carrier with webs, e.g. belts, spooled tapes or films of quasi-infinite extent
A strain and stimulus sensor system includes stretchable sensors secured to a material configured to be worn by a user, a control system operably coupled to the sensors, and electrical connectors operably coupled to the control system. The sensors are configured to exhibit a change in electrical resistance as a function of mechanical deformation. Each of the electrical connectors is positioned on the sensor region to contact skin of the user and is configured to capture stimulus data. The control system is configured to send an electrical current through the sensors, measure an electrical resistance of the sensors responsive to the electrical current, and measure an electrical activity at the skin from the electrical connectors contacting the skin.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Education services, namely, providing online non-downloadable articles, research, and educational materials in the nature of videos in the fields of physical activity and sports for children; Conducting of educational conferences in the field of physical activity and sports for children; Entertainment services, namely, providing podcasts in the field of physical activity and sports for children; Providing on-line newsletters in the field of physical activity and sports for children
A scalable flat in-plane-motion mechanical spring device. The device sincludes a frame with one or more flexures attached to the frame on a first end of the one or more flexures. The device further includes a shuttle with one or more of the one or more flexures attached to the shuttle on a second end of the one or more flexures. The frame, the shuttle, and the one or more flexures may be formed as a single piece.
F16F 1/02 - Springs made of steel or other material having low internal frictionWound, torsion, leaf, cup, ring or the like springs, the material of the spring not being relevant
Disclosed is a rigidity measuring device comprising an arm. The arm includes a rail and a base connected to the rail. The rail includes a limit switch, and the base includes a load cell. Also, disclosed is a rigidity measuring device comprising an arm and a processor. The arm includes a rail and a base connected to the rail. The rail includes a limit switch, and the base includes a load cell. The processor electronically connects to the limit switch and the load cell.
B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B22F 10/14 - Formation of a green body by jetting of binder onto a bed of metal powder
B22F 10/50 - Treatment of workpieces or articles during build-up, e.g. treatments applied to fused layers during build-up
B22F 10/85 - Data acquisition or data processing for controlling or regulating additive manufacturing processes
B22F 12/90 - Means for process control, e.g. cameras or sensors
B28B 1/00 - Producing shaped articles from the material
B28B 17/00 - Details of, or accessories for, apparatus for shaping the materialAuxiliary measures taken in connection with such shaping
B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
Bioresorbable cationic steroidal antimicrobial (CSA) compounds having a structure of Formula I, II or III, or salt thereof, wherein at least one of R1-R18, (e.g., R18) includes a mono-or diglyceride of a fatty acid attached via an ester linkage and at least one R1-R18, (e.g., R3, R7 and R12) is an amino acid linked to the steroidal backbone via an ester or amide linkage:
Bioresorbable cationic steroidal antimicrobial (CSA) compounds having a structure of Formula I, II or III, or salt thereof, wherein at least one of R1-R18, (e.g., R18) includes a mono-or diglyceride of a fatty acid attached via an ester linkage and at least one R1-R18, (e.g., R3, R7 and R12) is an amino acid linked to the steroidal backbone via an ester or amide linkage:
Bioresorbable cationic steroidal antimicrobial (CSA) compounds having a structure of Formula I, II or III, or salt thereof, wherein at least one of R1-R18, (e.g., R18) includes a mono-or diglyceride of a fatty acid attached via an ester linkage and at least one R1-R18, (e.g., R3, R7 and R12) is an amino acid linked to the steroidal backbone via an ester or amide linkage:
wherein:
R18 has the following structure:
Bioresorbable cationic steroidal antimicrobial (CSA) compounds having a structure of Formula I, II or III, or salt thereof, wherein at least one of R1-R18, (e.g., R18) includes a mono-or diglyceride of a fatty acid attached via an ester linkage and at least one R1-R18, (e.g., R3, R7 and R12) is an amino acid linked to the steroidal backbone via an ester or amide linkage:
wherein:
R18 has the following structure:
—R19—(C═O)—O—C—CR20—CR21
Bioresorbable cationic steroidal antimicrobial (CSA) compounds having a structure of Formula I, II or III, or salt thereof, wherein at least one of R1-R18, (e.g., R18) includes a mono-or diglyceride of a fatty acid attached via an ester linkage and at least one R1-R18, (e.g., R3, R7 and R12) is an amino acid linked to the steroidal backbone via an ester or amide linkage:
wherein:
R18 has the following structure:
—R19—(C═O)—O—C—CR20—CR21
where R19 is omitted or selected from alkyl, alkenyl, alkynyl, and aryl, and R20 and R21 are independently selected from hydroxy, alkylcarboxy, and aminoalkylcarboxy, provided that at least one of R20 or R21 is an alkylcarboxy,
R3, R7 and R12 have the following structure:
Bioresorbable cationic steroidal antimicrobial (CSA) compounds having a structure of Formula I, II or III, or salt thereof, wherein at least one of R1-R18, (e.g., R18) includes a mono-or diglyceride of a fatty acid attached via an ester linkage and at least one R1-R18, (e.g., R3, R7 and R12) is an amino acid linked to the steroidal backbone via an ester or amide linkage:
wherein:
R18 has the following structure:
—R19—(C═O)—O—C—CR20—CR21
where R19 is omitted or selected from alkyl, alkenyl, alkynyl, and aryl, and R20 and R21 are independently selected from hydroxy, alkylcarboxy, and aminoalkylcarboxy, provided that at least one of R20 or R21 is an alkylcarboxy,
R3, R7 and R12 have the following structure:
R24R23N—R22—(C═O)—X—
Bioresorbable cationic steroidal antimicrobial (CSA) compounds having a structure of Formula I, II or III, or salt thereof, wherein at least one of R1-R18, (e.g., R18) includes a mono-or diglyceride of a fatty acid attached via an ester linkage and at least one R1-R18, (e.g., R3, R7 and R12) is an amino acid linked to the steroidal backbone via an ester or amide linkage:
wherein:
R18 has the following structure:
—R19—(C═O)—O—C—CR20—CR21
where R19 is omitted or selected from alkyl, alkenyl, alkynyl, and aryl, and R20 and R21 are independently selected from hydroxy, alkylcarboxy, and aminoalkylcarboxy, provided that at least one of R20 or R21 is an alkylcarboxy,
R3, R7 and R12 have the following structure:
R24R23N—R22—(C═O)—X—
where R22 is substituted or unsubstituted alkyl, X is oxygen or nitrogen, and R23 and R24 are independently hydrogen, alkyl, alkenyl, alkynyl, or aryl.
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
22.
OBSERVATION AND CONTROL OF POWDER BED FUSION PROCESSES VIA MELT DETECTION
Disclosed is a method for observing and controlling powder melting in a 3-dimensional printer receiving input from a computing device. The 3-dimensional printer initiates the melting of powder on a powder bed. The 3-dimensional printer receives real-time feedback based on information from one or more optical sensors. The 3-dimensional printer adjusts output based on feedback from the optical sensors, and the 3-dimensional printer executes the melting of the powder on the powder bed based on the adjustments.
B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B29C 64/153 - Processes of additive manufacturing using only solid materials using layers of powder being selectively joined, e.g. by selective laser sintering or melting
Time multiplexing an electromagnetic trap beam may be used to generate trap shapes/geometries to trap one or more particles with one electromagnetic beam by directing the electromagnetic beam at a pattern of different locations with sufficient rapidity to form an effective shape/geometry. Additionally, multiplexing an electromagnetic trap beam may be used to shutter trapping electromagnetic radiation to protect a viewer, use the same beam for multiple functions, move and organize particles, and generate illumination effects.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Entertainment services in the nature of live visual and audio performances, namely, musical, variety, news and comedy shows; Entertainment services, namely, providing music tours in the nature of live musical performances
09 - Scientific and electric apparatus and instruments
Goods & Services
Musical sound recordings; Pre-recorded CDs featuring music and musical performances; Downloadable musical sound recordings; Audio and video recordings featuring music and artistic performances
Disclosed is a rigidity measuring device comprising an arm. The arm includes a rail and a base connected to the rail. The rail includes a limit switch, and the base includes a load cell. Also, disclosed is a rigidity measuring device comprising an arm and a processor. The arm includes a rail and a base connected to the rail. The rail includes a limit switch, and the base includes a load cell. The processor electronically connects to the limit switch and the load cell.
A novel treatment for Graves' Disease (GD) is disclosed and described. Chimeric autoantigen receptor (CAAR) T cells are engineered using a CAAR construct causing thyroid stimulating hormone receptor (TSHR) epitope expression such that the engineered CAAR T cells serve as bait for autoreactive B cells. The engineered CAAR T cells specifically eliminate the autoreactive B cells, thus eliminating the causative factor for GD. Certain CAAR T cells are further engineered to incorporate bispecific LINK CAR technology to further require the presence of CD19 or BCMA to further increase CAAR T cell targeting specificity to autoreactive B cells and plasma cells.
A prosthetic venous valve device is disclosed and described, having a valve base including a cylindrical shape with a lumen configured for axial blood flow, the valve base further including an anterograde end and a retrograde end, a pair of flexure pivots coupled to opposite sides of the valve base at the anterograde end, and a pair of leaflets opposingly positioned with respect to one another and each pivotally coupled to one of the pair of flexure pivots, the pair of leaflets being separated from one another in a default open position, wherein the pair of leaflets are structurally configured to pivot from the default open position toward one another to close the prosthetic venous valve to limit retrograde venous blood flow under normal physiologic venous conditions.
Microbially-resistant materials are disclosed and described, along with devices, surfaces, and associated methods. Such materials can be coated onto device surfaces, system surfaces, structures, and the like.
Hybrid suspension cultures supplementing soluble extracellular matrix (ECM) for growth of organoids is disclosed. Viable lung organoid from epithelial, endothelial, and fibroblast human stable cell lines in suspension culture are also disclosed.
In a general aspect, an apparatus configured for attachment to a vehicle can include: an alignment mechanism configured, as result of movement of the vehicle relative to a plant stalk, to place the plant stalk in a known position relative to the apparatus; a deflection mechanism configured, as result of at least one of the movement of the vehicle relative to the plant stalk or rotational movement of the deflection mechanism, to move the plant stalk from the known position to a deflected position, the deflected position being a distance from the known position; and a force sensor configured to determine an amount of force applied to move the plant stalk from the known position to the deflected position.
A method and system for physical layer security are disclosed. In one embodiment, a sender may encode a message word using a secrecy-code encoding, an error-propagation encoding, and an error-correction encoding. The sender may then transmit the encoded message word on a data transmission medium. An intended recipient may receive, on its channel on the data transmission medium, a word having errors from the noise on the intended recipient's channel, and may decode the received word using an error-correction decoder, an error-propagation decoder, and a secrecy-code decoder. Assuming that an eavesdropper's channel is noisier than the intended recipient's channel, the system may be tuned to correct all errors on the intended recipient's channel, but leave, on the eavesdropper's channel, errors that will be propagated and amplified into noise. In an alternate embodiment, a sender and an intended recipient may share a secret key and may use the shared secret key, or values generated by the shared secret key, to populate frozen bits in a polar coding scheme. Because the eavesdropper does not know the shared secret, the eavesdropper's application of successive cancellation decoding results in only noise. This embodiment works as long as the eavesdropper has some noise on its channel.
Systems and methods for producing organisms that lack one or more undesired traits are disclosed. In some implementations, a method includes obtaining (or producing) a first parent organism of a donor family of breeding stock and obtaining (or producing) a second parent organism from a receptor family of breeding stock. Some implementations of the method include mating the first parent organism with the second parent organism to produce a progeny organism. In some cases, a combination of genetic material from the first parent organism and the second parent organism in the progeny organism prevents development of the undesired trait (or of an organism having the undesired trait). Other implementations are also described.
Disclosed is a reference electrode that includes a tube, saturated reference salt, an excess reference salt, and a wire. The saturated reference salt and the excess reference salt are placed inside the tube. The wire is also placed inside the tube. Also disclosed is a system comprising a crucible, a working electrode, a counter electrode, and a reference electrode. The crucible contains molten salt. The electrodes are placed within the molten salt. The reference electrode that includes a tube, saturated reference salt, an excess reference salt, and a wire. The saturated reference salt and the excess reference salt are placed inside the tube. The wire is also placed inside the tube.
An example autoignition system includes a pressure vessel defining a vessel chamber. The vessel chamber is configured to be pressurized to about 101 kPa (1 atmosphere). The autoignition system also includes a furnace disposed in the vessel chamber. The furnace defines a furnace chamber and the furnace is configured to control the temperature of the furnace chamber. The furnace also defines at least one sample inlet. The autoignition system additionally includes at least one gas source configured to supply a gas to the vessel chamber thereby pressurizing the vessel chamber to about 101 kPa and at least one pressure sensor configured to determine a pressure of the vessel chamber.
G01N 25/52 - Investigating or analysing materials by the use of thermal means by investigating flash-pointInvestigating or analysing materials by the use of thermal means by investigating explosibility by determining flash-point of liquids
A method includes etching metallic impurities from an aluminosilicate mineral in a liquid acid etchant and separating solids including silica from the liquid acid etchant. The method further includes reducing the silica in the separated solids to silicon using a solid reducing agent resulting in a silicon-residual silica composite, removing aluminum chloride from the silicon-residual silica composite, dissolving oxides of the solid reducing agent in an acid solution, and separating silicon-residual silica solids remaining in the acid solution from the acid solution. The separated silicon-residual silica solids are dried to produce a clay mineral-derived silicon product.
Embodiments disclosed are vehicle seat systems for restricting yielding or deflection of a seatback in a rear-impact collision, and related methods. In an embodiment, a vehicle seat system includes a vehicle seat and a seatback deformation limiting system. The vehicle seat includes a seat bottom frame and a seatback frame secured to the seat bottom. The seatback deformation limiting system includes a frame assembly and a computer system. The frame assembly is configured to selectively allow the seatback frame to yield and also selectively limit or inhibit the seatback frame from yielding. The computer system is configured to detect a rear-impact collision in a vehicle, wherein the frame assembly is operably coupled to the computer system and, responsive to the computer system detecting the rear-impact collision in the vehicle, configured to limit or inhibit the seatback frame from yielding towards a rearward seat in the vehicle directly behind the vehicle seat.
A device using resorbable materials to actuate, such as a device (10) for repairing pectus excavatum in a patient through activation of a bioresorbable material (40, 52).
A disclosed system uses modulations of ionic current across a nanopore in a membrane to detect target molecules passing through the nanopore. This principle has been applied mainly to nucleic acid sequencing, but can also be used to detect other molecular targets such as proteins and small molecules. In addition, the system delivers target molecules to a nanopore to provide label-free single molecule analysis using a chip-based system. Target molecules are concentrated on microscale carrier beads, and the beads are delivered and optically trapped in an area within the capture radius of the nanopore. The target molecules are released from the beads and detected using nanopore current modulation. In addition, the disclosed system combines sample preparation (e.g. purification, extraction, and pre-concentration) with nanopore-based readout on a microfluidic chip. Finally, target molecules can be specifically bound to carrier beads and particles are positioned within the capture volume of a nanopore using a chip-based microfluidic platform proven to handle specific detection of molecular targets from milliliters of raw sample.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
G01N 33/487 - Physical analysis of biological material of liquid biological material
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
41.
GALECTIN-1 IMMUNOMODULATION AND MYOGENIC IMPROVEMENTS IN MUSCLE DISEASES AND AUTOIMMUNE DISORDERS
A method of treating a disease associated with chronic, NFκB canonical inflammation is disclosed herein. The method includes administering to a patient a suitable amount of a galectin-1 protein or fragment thereof. Treatment with a recombinant galectin-1 reduced inflammation in key inflammatory pathways.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
42.
Compositions and methods for treating pain with wogonin
The invention described herein relates to compositions and methods for treating pain with wogonin. In particular, described herein are compositions and methods for treating musculoskeletal pain and arthritis with wogonin.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
43.
Methods and devices for selecting miniaturized impedance electrodes of miniaturized impedance sensors
A method, system, apparatus, and/or device to select a depth within a body part to measure an impedance. The method, system, apparatus, and/or device may include: a band configured to extend at least partially around a body part of a user; a user interface coupled to the band; a miniaturized impedance sensor embedded in the band and positioned in the band to be pressed against the body part when the user wears the band, the miniaturized impedance sensor including an array of miniaturized electrodes, where the array of miniaturized electrodes is configured to measure an impedance at a depth within the body part and the depth corresponds to a subdermal feature within the body part; a processing device coupled to the band, where the processing device is configured to select the depth within the body part to measure an impedance; and an electrical circuit embedded in the band.
A method, system, apparatus, and/or device to determine a condition of a user using a spectrometer with a collimator on a glass substrate. The method, system, apparatus, and/or device may include: a band comprising a shape, size, and flexibility designed for attaching the band to a body part of a user; a light source embedded in the band that emits light comprising a constituent wavelength that provides an indication of a feature of the body part; an optical sensor positioned in the band to receive the constituent wavelength; and a glass substrate oriented in the band to receive the light, the glass substrate comprising: an optical filter that comprises a passband to isolate the constituent wavelength from other wavelengths of the light; and a carbon nanotube grid structure comprising walls and through-channels, the carbon nanotube grid structure adhered to the glass substrate.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
Methods of treating, reducing, or preventing lung infections and/or lung inflammation include identifying a patient in need of treatment and administering a therapeutically or prophylactically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Treatment of cystic fibrosis lung infections, COPD lung infections, inflammation of the lungs in these patient populations, and lung scarring in these patient populations is also described.
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Embodiments disclosed herein relate to methods and systems for determining thermal properties of materials by using frequency modulated pump light intensity to cyclically heat a sample, and using probe light to induce reflected light from reflective materials on the surface of the material during the cyclic heating. The pump and probe light may be emitted onto a plurality of locations on a material sample simultaneously. The methods and systems utilize the phase delay between the frequency modulated pump light and the corresponding reflected light to determine the thermal properties of the material at a plurality of the locations on the material sample simultaneously.
G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
G01N 25/18 - Investigating or analysing materials by the use of thermal means by investigating thermal conductivity
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G02B 26/02 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/39 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
32 - Beers; non-alcoholic beverages
35 - Advertising and business services
43 - Food and drink services, temporary accommodation
Goods & Services
Buttermilk; Milk; Yogurt; Chocolate milk; Fruit salads and vegetable salads; Whipping cream Ice cream; Salad dressing Orange juice Retail grocery store services Ice cream shop services in the nature of a restaurant; Restaurant services
Various technologies are described herein pertaining to laser ablation of material from a workpiece. An ablation system includes a laser, a focusing system, and a computing device configured to control operation of the laser and the focusing system. The laser emits light that is received by the focusing system. The computing device controls operation of the laser and/or the focusing system such that the focusing system focuses the light emitted by the laser to a focal spot on a surface of a workpiece. The focused light causes ablation of the workpiece at the focal spot.
H01L 21/302 - Treatment of semiconductor bodies using processes or apparatus not provided for in groups to change the physical characteristics of their surfaces, or to change their shape, e.g. etching, polishing, cutting
B23K 26/03 - Observing, e.g. monitoring, the workpiece
B23K 26/0622 - Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses
B23K 26/067 - Dividing the beam into multiple beams, e.g. multi-focusing
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
51.
Developable and collapsable internal cutting mechanism
A hollow rod developable actuator tool including a first link comprising an outer cylinder, a second link comprising a first tool member pivotably connected to the first link at a first joint mounted in a first cavity in the wall of the outer cylinder, a third link comprising a second tool member pivotably connected to the first tool member at a second link, and a fourth link comprising an inner cylinder to which the second tool member is also pivotably connected at a third link mounted in a second cavity in the wall of the inner cylinder. When the inner cylinder of the fourth link is rotated in relation to the outer cylinder of the first link the actuator tool transitions from a first state where the tool is closed to a second state where the tool is open.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
41 - Education, entertainment, sporting and cultural services
Goods & Services
Clothing, namely, shirts Education services, namely, providing conferences and workshops in the field of religious education, motivation, interpersonal relationships, and communication
53.
Methods and devices for aligning miniaturized impedance sensors in wearable devices
A method, system, apparatus, and/or device to align a miniaturized impedance sensor over the muscular-walled tube of a user. The method, system, apparatus, and/or device may include: a band comprising a shape, size, and flexibility designed for attaching the band to a body part of a user, where the body part includes a dermal layer and a muscular-walled tube; a miniaturized impedance sensor embedded in the band and positioned in the band to be pressed against a portion of the body part adjacent to the muscular-walled tube as the user wears the band, where the miniaturized impedance sensor may include two or more miniaturized electrode strips or an array of miniaturized electrode pillars; and an alignment device embedded in the band and configured in the band to align the miniaturized impedance sensor over the muscular-walled tube as the user wears the band.
Devices, systems, and methods for eliminating noise in non-invasive biological interrogation techniques may be described herein. A method may include taking a first set of measurements over a time period. The first set of measurements may be indicated by an electronic signal. The first set of measurements may correspond to a physiological characteristic of a subject. A change in the physiological characteristic of the subject may correspond to a change in a blood constituent of the subject. The method may include: taking a second set of measurements over the time period; correlating the first and second sets of measurements, wherein the correlating removes noise from the electronic signal; sectioning out the electronic signal; calculating an amplitude difference between two or more sections of the electronic signal; and determining a change in the amount of the blood constituent based on the difference.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body
55.
DEVICE AND METHOD TO INDUCE VIBRATIONAL WAVEFORMS THAT HETERODYNE IN THE BODY TO IMPROVE SLEEP ONSET AND SLEEP QUALITY
A system for introducing vibrational waves into a body of a subject to treat sleep disorders is provided. The system includes a bed frame having a first vibration contact and a second vibration contact. The first vibration contact is in mechanical communication with a first location of the body of the subject, and the second vibration contact is in mechanical communication with a second location of the body of the subject. A first vibration source is connected to the first vibration contact and configured to cause a first vibration of the first vibration contact. A second vibration source is connected to the second vibration contact and configured to cause a second vibration of the second vibration contact. The location or orientation of the first vibration contact and the second vibration contact are configured such that the first vibration combines with the second vibration to generate a super-imposed vibration.
A61M 21/02 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
56.
HIGH THROUGHPUT LIQUID CHROMOTOGRAPHY USING LOW FLOWRATE
A high-duty-cycle liquid chromatography system that includes two or more columns that are configured to alternatingly be in a productive phase or a regeneration phase, wherein simultaneously one of the columns is in a productive phase and the other columns are in the regeneration phase. Additionally, the system includes a mobile phase gradient delivery pump, an isocratic pump, two or more gradient storage chambers, and two or more valves that are each independently coupled to a column and a gradient storage chamber. The column in the productive phase has a solution containing a sample which is pushed through the column, collected at a detector, and analyzed. The column in the regeneration phase is being prepared for the next productive phase.
A device and methodology for cleaning optical instruments. The device includes a sheath, a wiper mechanism, and an actuator. The sheath attaches to an optical instrument such that the wiper mechanism is in proximity to a lens of the optical instrument. The wiper mechanism includes a blade and a compliant deployment system having first and second curved cross members attached to the blade and sheath such that they bias the blade in a first state where the blade is in a deployed position but can de-form allowing the blade to transition to a second state in a stored position. The actuator maintains tension on the blade to keep the blade in the second state and when the actuator releases tension on blade spring energy stored by the deformation of the curved cross members is released transitioning the blade to the first deployed position providing a wipe of the wiper mechanism.
A61B 1/12 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with cooling or rinsing arrangements
A61B 90/70 - Cleaning devices specially adapted for surgical instruments
59.
Miniaturized impedance sensors for wearable devices
A method, system, apparatus, and/or device for measuring a physiological condition of a user. The method, system, apparatus, and/or device may include: a band configured to attach to a body part of a user; a housing coupled to the band; a processing device integrated into the band or disposed within the housing; an interface integrated into the band or disposed within the housing; and a miniaturized impedance sensor.
Compliant connectors can span gaps between support segments of an expandable implantable spinal device. The compliant connectors can lay flat when under strain in a stowed position and can expand to maintain an expanded configuration defined by the plurality of support segments when released. A minimally compact size and/or profile of the expandable implantable device may be achieved, which also achieving a relatively large size in the deployed configuration of the device.
Limb-girdle muscular dystrophy type 2B (LGMD2B) is caused by mutations in the dysferlin gene, resulting in non-functional dysferlin, a key protein found in muscle membrane. Treatment options available for patients are chiefly palliative in nature and focus on maintaining ambulation. A method of treating LGMD2B is disclosed herein. The method includes administering to a patient a suitable amount of a galectin protein or fragment thereof. Treatment with a recombinant galectin promoted myogenic maturation as indicated through improvements in size, myotube alignment, myoblast migration, and membrane repair capacity in dysferlin-deficient myo tubes, explant myofibers and mice.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
62.
METHOD AND SYSTEM FOR GENERATING A THREE-DIMENSIONAL OBJECT WITH EDGE DEFINITION
A method of forming a three-dimensional (3D) object, the method including forming a layer of powder, dispensing a volatile fluid on the layer of the powder, vaporizing the volatile fluid by applying an energy beam to form a trench that defines a boundary of a 3D object powder layer of the 3D object, the 3D object powder layer corresponding to a portion of the layer of the powder defined by the boundary, and adding a binder to the 3D object powder layer.
2-phosphinyl bicyclic amidine; ii) an organoaluminum compound, and iii) optionally an organic reaction medium; and b) forming an oligomer product in a reaction zone.
C07C 2/36 - Catalytic processes with hydrides or organic compounds as phosphines, arsines, stilbines or bismuthines
B01J 31/14 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
C07F 11/00 - Compounds containing elements of Groups 6 or 16 of the Periodic Table
The present disclosure relates to a catalyst system comprising i) (a) a bicyclic 2-[(phosphinyl)aminyl] cyclic imine chromium salt or (b) a chromium salt and a bicyclic 2-[(phosphinyl)aminyl] cyclic imine and ii) an organoaluminum compound. The present disclosure also relates to a process comprising: a) contacting i) ethylene; ii) a catalyst system comprising (a) a 2-[(phosphinyl)aminyl] cyclic imine chromium salt complex or (b) a chromium salt and a bicyclic 2-[(phosphinyl)aminyl] cyclic imine; ii) an organoaluminum compound, and iii) optionally an organic reaction medium; and b) forming an oligomer product in a reaction zone.
B01J 31/14 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
Protein compositions for the treatment of cancer that concomitantly reduce metastasis are disclosed. The proteins include three functional domains for targeting cancer cells, promoting tumor cell adhesion, and signaling to CAR-T cells. Methods of using and making the proteins are also disclosed.
A method, system, apparatus, and/or device to determine a condition of a user using a miniaturized collimator. The method, system, apparatus, and/or device may include: a carbon nanotube structure comprising a microtube that includes a set of aligned carbon nanotubes infiltrated by carbon and a through-channel, the carbon nanotube structure having a defined height to through-channel width aspect ratio, where: the defined height to through-channel width aspect ratio is based on a defined collimation to diffraction ratio; the set of aligned carbon nanotubes infiltrated by carbon is configured to absorb a first portion of light that travels through the through-channel at a first angle and impinges a side of a first through-channel portion; and the set of aligned carbon nanotubes infiltrated by the carbon is configured to allow a second portion of the light that enters the through-channel at a second angle to pass through the through-channel.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Education services, namely, providing conferences and workshops in the fields of religious education, motivation, interpersonal relationships, and communication
41 - Education, entertainment, sporting and cultural services
Goods & Services
Education services, namely, providing conferences and workshops in the fields of religious education, motivation, interpersonal relationships, and communication
A lamina emergent torsional (LET) joint that includes an integrated membrane to reduce, or eliminate, certain unwanted motions and/or displacements associated with the operation of the LET joint is disclosed. The membrane-integrated LET joint (i.e., M-LET) can be used as a hinge for a lamina emergent mechanism and/or as a surrogate fold for an origami application to ensure accurate and repeatable transitions from a planar (i.e., lamina) state to a non-planar (i.e., lamina-emergent) state, and vice versa.
F16F 1/02 - Springs made of steel or other material having low internal frictionWound, torsion, leaf, cup, ring or the like springs, the material of the spring not being relevant
71.
Methods and devices for aligning miniaturized spectrometers and impedance sensors in wearable devices
A method, system, apparatus, and/or device to determine a condition of a user using multiple sensors. The method, system, apparatus, and/or device may include: a band configured to extend at least partially around a body part of a user having a subdermal feature within body part; a light configured in the band to emit light into the body part; a miniaturized spectrometer positioned in the band to press against the body part to receive the light, where the miniaturized spectrometer comprises: an optical filter configured to isolate a relevant constituent wavelength of the light; a collimator configured to collimate the light; and an optical sensor configured to detect an intensity of the relevant constituent wavelength; and an impedance sensor integrated into the band and configured to be positioned against a same side of the body part as the miniaturized spectrometer.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G04G 21/02 - Detectors of external physical values, e.g. temperature
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G06F 1/16 - Constructional details or arrangements
72.
Chromium phosphinyl isoindole amidine complexes for tetramerization of ethylene
The present disclosure relates to a catalyst system comprising i) (a) a bicyclic 2-[(phosphinyl)aminyl] cyclic imine chromium salt or (b) a chromium salt and a bicyclic 2-[(phosphinyl)aminyl] cyclic imine and ii) an organoaluminum compound. The present disclosure also relate to a process comprising: a) contacting i) ethylene; ii) a catalyst system comprising (a) a 2-[(phosphinyl)aminyl] cyclic imine chromium salt complex or (b) a chromium salt and a bicyclic 2-[(phosphinyl)aminyl] cyclic imine; ii) an organoaluminum compound, and iii) optionally an organic reaction medium; and b) forming an oligomer product in a reaction zone.
Embodiments disclosed are systems and methods for fabricating microchannels in metal. In an embodiments, a method includes providing a first metallic plate having a first surface with an elongated slot recessed therein, providing a second metallic plate having a second surface, interfacing the first surface of the first metallic plate with the second surface of the second metallic plate with the second surface covering the elongated slot to form a microchannel between the first metallic plate and the second metallic plate, thermal bonding the first metallic plate to the second metallic plate to form a metallic body having the microchannel extending therethrough, and infiltrating the metallic body with an infiltrant.
B22F 5/10 - Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product of articles with cavities or holes, not otherwise provided for in the preceding subgroups
B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices
74.
Method and compositions for the treatment of anemia through the inhibition of furin
Methods and compositions that can be used to modulate the activity of furin in a subject are disclosed herein. In some embodiments, the methods include administering a pharmaceutical composition including a protease inhibitor. In some embodiments, the protease inhibitor inhibits furin activity by binding to the catalytic site, the allosteric site, or both.
A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
Embodiments disclosed are systems and methods for interfacing a metallic capillary in a microchannel of a metallic body. A method may include inserting a portion of the metallic capillary into a portion the microchannel of the metallic body, sintering the portion of the metallic capillary to the portion of the microchannel of the metallic body, disposing a sacrificial powder at least proximate to the metallic capillary and the metallic body after sintering the portion of the metallic capillary and the portion of the microchannel of the metallic body, and infiltrating at least the portion of the metallic capillary sintered to the portion of the microchannel of the metallic body with an infiltrant in the presence of the sacrificial powder disposed at least proximate to the metallic capillary and the metallic body.
F28D 15/04 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes with tubes having a capillary structure
B22F 5/10 - Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product of articles with cavities or holes, not otherwise provided for in the preceding subgroups
B22F 10/28 - Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
B22F 10/62 - Treatment of workpieces or articles after build-up by chemical means
B33Y 40/20 - Post-treatment, e.g. curing, coating or polishing
B33Y 70/00 - Materials specially adapted for additive manufacturing
B33Y 80/00 - Products made by additive manufacturing
B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices
B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
F28D 15/02 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes
76.
STIFFNESS AND STRENGTH ASSESSMENT OF GROWING PLANT MATERIAL
In a general aspect, an apparatus configured for attachment to a vehicle can include: an alignment mechanism configured, as result of movement of the vehicle relative to a plant stalk, to place the plant stalk in a known position relative to the apparatus; a deflection mechanism configured, as result of at least one of the movement of the vehicle relative to the plant stalk or rotational movement of the deflection mechanism, to move the plant stalk from the known position to a deflected position, the deflected position being a distance from the known position; and a force sensor configured to determine an amount of force applied to move the plant stalk from the known position to the deflected position.
An example autoignition system includes a pressure vessel defining a vessel chamber. The vessel chamber is configured to be pressurized to about 101 kPa (1 atmosphere). The autoignition system also includes a furnace disposed in the vessel chamber. The furnace defines a furnace chamber and the furnace is configured to control the temperature of the furnace chamber. The furnace also defines at least one sample inlet. The autoignition system additionally includes at least one gas source configured to supply a gas to the vessel chamber thereby pressurizing the vessel chamber to about 101 kPa and at least one pressure sensor configured to determine a pressure of the vessel chamber.
A device using resorbable materials to actuate, such as a device (10) for repairing pectus excavatum in a patient through activation of a bioresorbable material (40, 52).
Embodiments disclosed are vehicle seat systems for restricting yielding or deflection of a seatback in a rear-impact collision, and related methods. In an embodiment, a vehicle seat system includes a vehicle seat and a seatback deformation limiting system. The vehicle seat includes a seat bottom frame and a seatback frame secured to the seat bottom. The seatback deformation limiting system includes a frame assembly and a computer system. The frame assembly is configured to selectively allow the seatback frame to yield and also selectively limit or inhibit the seatback frame from yielding. The computer system is configured to detect a rear-impact collision in a vehicle, wherein the frame assembly is operably coupled to the computer system and, responsive to the computer system detecting the rear-impact collision in the vehicle, configured to limit or inhibit the seatback frame from yielding towards a rearward seat in the vehicle directly behind the vehicle seat.
A method includes etching metallic impurities from an aluminosilicate mineral in a liquid acid etchant and separating solids including silica from the liquid acid etchant. The method further includes reducing the silica in the separated solids to silicon using a solid reducing agent resulting in a silicon-residual silica composite, removing aluminum chloride from the silicon-residual silica composite, dissolving oxides of the solid reducing agent in an acid solution, and separating silicon-residual silica solids remaining in the acid solution from the acid solution. The separated silicon-residual silica solids are dried to produce a clay mineral-derived silicon product.
B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
B82Y 40/00 - Manufacture or treatment of nanostructures
C01B 33/023 - Preparation by reduction of silica or silica-containing material
2-phosphinyl bicyclic amidine; ii) an organoaluminum compound, and iii) optionally an organic reaction medium; and b) forming an oligomer product in a reaction zone.
B01J 31/14 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
Hybrid suspension cultures supplementing soluble extracellular matrix (ECM) for growth of organoids is disclosed. Viable lung organoid from epithelial, endothelial, and fibroblast human stable cell lines in suspension culture are also disclosed.
The present disclosure relates to a catalyst system comprising i) (a) a bicyclic 2-[(phosphinyl)aminyl] cyclic imine chromium salt or (b) a chromium salt and a bicyclic 2-[(phosphinyl)aminyl] cyclic imine and ii) an organoaluminum compound. The present disclosure also relate to a process comprising: a) contacting i) ethylene; ii) a catalyst system comprising (a) a 2-[(phosphinyl)aminyl] cyclic imine chromium salt complex or (b) a chromium salt and a bicyclic 2-[(phosphinyl)aminyl] cyclic imine; ii) an organoaluminum compound, and iii) optionally an organic reaction medium; and b) forming an oligomer product in a reaction zone.
B01J 31/14 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
84.
Deployable structures, methods including the same and systems including the same
An example deployable structure includes at least one base member, at least one first articulable member, at least one second articulable member, and at least one interference member. The deployable structure must include at least one base member, at least one first articulable member, at least one second articulable member, and at least one interference member otherwise the deployable structure may not be switchable between the compact and deployed states thereof. The base member is articulably connected to the first articulable member using a first hinge, the first articulable member is articulably connected to the second articulable member using a second hinge, and the interference member is articulably connected to the second articulable member using a third hinge. The interference member is also attached to the base member, for example, using a fourth hinge. The deployable structure is configured to switch from at least a compact state to a deployed state.
F16M 11/00 - Stands or trestles as supports for apparatus or articles placed thereon
F16M 13/02 - Other supports for positioning apparatus or articlesMeans for steadying hand-held apparatus or articles for supporting on, or attaching to, an object, e.g. tree, gate, window-frame, cycle
85.
3D-PRINTED MICROFLUIDIC DEVICES FOR SOLID-PHASE EXTRACTION AND FLUORESCENT LABELING OF PEPTIDES AND PROTEINS
Miniaturized solid-phase extraction (SPE) systems and processes are disclosed. The systems and methods enable preconcentration methods for sample preparation that can be performed on a variety of specimens. The miniaturization of SPE system is accomplished with 3D-printed microfluidic device for fast and simple extraction of analytes.
A method, system, apparatus, and/or device to determine a condition of a user using a wearable device with a miniaturized spectrometer. The method, system, apparatus, and/or device may include: a band configured to extend at least partially around a body part of a user, the body part comprising an internal feature within the body part; a light source embedded in the band, where the light source is configured to emit light into the body part as the user wears the band; a collimator; an optical filter; and an optical sensor, where the collimator, optical sensor, or the optical filter are arranged together to form a stack embedded in the band.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
An apparatus configured to perform non-destructive, electrical measurements on a plant stalk to detect and quantify internal damage is disclosed. This apparatus includes features to minimize misalignments that can negatively affect the precision and/or accuracy of the electrical measurements.
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
Downloadable magazines in the field of campus life, higher education, sports, entertainment, and the arts Printed magazines in the field of campus life, higher education, sports, entertainment, and the arts Providing information, news and commentary in the field of current events relating to campus life, higher education, sports, entertainment, and the arts.; Providing on-line non-downloadable newspapers; Providing on-line magazines in the field of campus life, higher education, sports, entertainment, and the arts
89.
Composition, method, and system for a rapid, real-time pentaplex PCR assay for major beta-lactamase genes
Provided herein are a composition, system, and kit for the real-time pentaplex amplification and detection of DNA from at least one of beta-lactamase genes Klebsiella pneumoniae carbapenemase (KPC); New Delhi metallo-beta-lactamase (NDM); cefotaximase-Munich (CTX); cephamycin AmpC beta-lactamase (CMY); and oxacillinase-48 (OXA-48).
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
90.
METHOD FOR CONTROLLING PROTEIN DIMERIZATION USING AN INTRAMOLECULAR TO INTERMOLECULAR CONFORMATIONAL SWITCH
A system for regulating protein dimerization kinetics is provided herein. The system includes a first polypeptide comprising a first alpha helix forming amino acid sequence configured to bind a second alpha helix forming amino acid sequence linked by a first flexible linker peptide; and a second polypeptide comprising a third alpha helix forming amino acid sequence configured to bind a fourth alpha helix forming amino acid sequence linked by a second flexible linker peptide. The first alpha helix forming amino acid sequence and the third alpha helix forming amino acid sequence are configured to form a coiled coil. The second alpha helix forming amino acid sequence and the fourth alpha helix forming amino acid sequence are configured to form a coiled coil.
A system for regulating protein dimerization kinetics is provided herein. The system includes a first polypeptide comprising a first alpha helix forming amino acid sequence configured to bind a second alpha helix forming amino acid sequence linked by a first flexible linker peptide; and a second polypeptide comprising a third alpha helix forming amino acid sequence configured to bind a fourth alpha helix forming amino acid sequence linked by a second flexible linker peptide. The first alpha helix forming amino acid sequence and the third alpha helix forming amino acid sequence are configured to form a coiled coil. The second alpha helix forming amino acid sequence and the fourth alpha helix forming amino acid sequence are configured to form a coiled coil.
Disclosed herein are compounds having the following Formula (I) or a pharmaceutically acceptable salt form thereof: B-L-C (I) wherein B is a bone-binding moiety; L is a linker; and C is a cationic steroid antimicrobial (CSA) moiety, pharmaceutical compositions comprising the compounds, and methods of using the compounds or pharmaceutical compositions for the treatment of an infection or osteomyelitis in a bone of a subject, promotion of bone formation in a subject, or treatment of bone cancer or metastatic bone cancer in a subject.
A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
A61K 31/663 - Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
The present invention is a system and method for significantly improving gas chromatography resolution using a dynamic and non-linear thermal gradient along the entire column length and is achieved by decreasing the velocity of analytes when approaching the back end of the capillary column in order to compensate for an increase in velocity of carrier gas as the carrier gas expands when approaching the back end, and wherein the thermal gradient is selected so that the analyte achieves a constant velocity through the capillary column.
Described herein are compositions and methods for the prevention and/or treatment of at least one condition or disorder of a) skin and accessory structures of the skin, b) musculoskeletal system, c) cardiovascular system, d) inflammatory system, e) neurological system, f) cancer, and g) endocrine/metabolic system, and/or for improving the health status of a subject. The composition includes one or more polyphenolic compound, its isomer or analog; and one or more other active ingredient selected from the group consisting of collagen, vitamin C, vitamin E, zinc, grape seed extract, niacinamide, hydroxy acids, hyaluronic acid, and coenzyme Q10. The composition may also or alternatively include cannabidiol (CBD).
In a general aspect, an apparatus can include a plate configured for implantation in a body of a patient. The plate can include a plurality of pores and be configured for placement between a cancellous bone of a spinal vertebra and a corresponding cartilaginous endplate as a replacement for a bony endplate of the spinal vertebra.
In a general aspect, an apparatus can include a plate configured for implantation in a body of a patient. The plate can include a plurality of pores and be configured for placement between a cancellous bone of a spinal vertebra and a corresponding cartilaginous endplate as a replacement for a bony endplate of the spinal vertebra.
Systems, methods, and techniques for optofluidic analyte detection and analysis using multi-mode interference (MMI) waveguides are disclosed herein. In some embodiments, spatially and spectrally multiplexed optical detection of particles is implemented on an optofluidic platform comprising multiple analyte channels intersecting a single MMI waveguide. In some embodiments, multi-stage photonic structures including a first stage MMI waveguide for demultiplexing optical signals by spatially separating different wavelengths of light from one another may be implemented. In some embodiments, a second stage may use single-mode waveguides and/or MMI waveguides to create multi-spot patterns using the demultiplexed, spatially separated light output from the first stage. In some embodiments, liquid-core MMI (LC-MMI) waveguides that are tunable by replacing a liquid core, heating/cooling the liquid core, and/or deforming the LC-MMI to change its width may be implemented in one or more of the analyte detection/analysis systems disclosed herein.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
G02B 6/28 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference
98.
SYSTEMS AND METHODS FOR PRINTING A THREE-DIMENSIONAL OBJECT
Systems and methods for printing a three-dimensional object are described. A method may include providing a support matrix having a base component and depositing an ink having the base component, a catalyst, and a cross-linker into the support matrix. The ink may be deposited into the support matrix in a predetermined pattern effective to form a plurality of layers of the ink. The support matrix supports the plurality of layers of the ink, and portions of the support matrix are disposed between at layers of the ink when the plurality of layers are formed in the support matrix. The method also may include solidifying or curing the ink deposited into the support matrix and also the portions of the support matrix deposited between the layers of the ink to form the three-dimensional object.
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
The composition includes a first construct having a first portion of a protein and a first antigen-recognizing amino acid sequence; and a second construct having a second portion of the protein that catalyzes a reaction when combined with the first portion of the protein and a second antigen-recognizing amino acid sequence. The first and second synthetic constructs include a sulfhydryl group configured such that a disulfide bond is formed between the first and second synthetic constructs when the first antigen-recognizing amino acid sequence and the second antigen-recognizing amino acid sequence bind an antigen.
The composition includes a first construct having a first portion of a protein and a first antigen-recognizing amino acid sequence; and a second construct having a second portion of the protein that catalyzes a reaction when combined with the first portion of the protein and a second antigen-recognizing amino acid sequence. The first and second synthetic constructs include a sulfhydryl group configured such that a disulfide bond is formed between the first and second synthetic constructs when the first antigen-recognizing amino acid sequence and the second antigen-recognizing amino acid sequence bind an antigen.
C12N 15/62 - DNA sequences coding for fusion proteins
C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
G01N 33/535 - Production of labelled immunochemicals with enzyme label
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
