Wilson Wolf Manufacturing

United States of America

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IPC Class
C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells 15
C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means 13
A61K 39/00 - Medicinal preparations containing antigens or antibodies 6
C12M 1/00 - Apparatus for enzymology or microbiology 6
A61K 39/12 - Viral antigens 4
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Status
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Found results for  patents

1.

METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY

      
Application Number 18746679
Status Pending
Filing Date 2024-06-18
First Publication Date 2024-12-12
Owner
  • WILSON WOLF MANUFACTURING (USA)
  • BAYLOR COLLEGE OF MEDICINE (USA)
Inventor
  • Vera, Juan F.
  • Rooney, Cliona M.
  • Leen, Ann M.
  • Wilson, John R.

Abstract

Production and use of novel therapeutic cells, called T-Vehicles, in the allogeneic Adoptive Cell Therapy setting allows a wide range of therapeutic benefits to accrue with minimal or no risk of GVHD. T-Vehicles are created from donor T cells that are altered to contain therapeutic attributes that do not include their native antigen receptors and can deliver therapeutic benefits irrelevant of their native antigen specificity. T-Vehicles can possess highly restricted native antigen specificity that renders them unable to recognize antigens present on normal cells and incapable of initiating GVHD, making them ideal transport vehicles to deliver various therapeutic attributes in vivo. In essence, production and use of T-Vehicles is a paradigm shift that opens the door to therapeutic application of T cells in ways not previously contemplated, independent of whether or not there is an HLA match between the donor and the recipient.

IPC Classes  ?

  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 9/50 - Microcapsules
  • A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
  • A61K 51/08 - Peptides, e.g. proteins
  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means

2.

LONG TERM POTENCY ASSAYS FOR CELL AND GENE-MODIFIED CELL THERAPY

      
Application Number 18731199
Status Pending
Filing Date 2024-05-31
First Publication Date 2024-12-05
Owner Wilson Wolf Manufacturing (USA)
Inventor
  • Smith, Eric A.
  • Lewis, Andrew H.

Abstract

Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and gas permeable surface area to medium volume ratios, that do not conform to conventional wisdom. These novel devices and methods allow improvement in cell culture efficiency and scale up efficiency.

IPC Classes  ?

  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

3.

LONG TERM POTENCY ASSAYS FOR CELL AND GENE-MODIFIED CELL THERAPY

      
Application Number US2024032148
Publication Number 2024/249958
Status In Force
Filing Date 2024-05-31
Publication Date 2024-12-05
Owner WILSON WOLF MANUFACTURING (USA)
Inventor
  • Smith, Eric, A.
  • Lewis, Andrew, H.

Abstract

Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and gas permeable surface area to medium volume ratios, that do not conform to conventional wisdom. These novel devices and methods allow improvement in cell culture efficiency and scale up efficiency.

IPC Classes  ?

  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C07K 14/725 - T-cell receptors
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

4.

METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY

      
Application Number 18732410
Status Pending
Filing Date 2024-06-03
First Publication Date 2024-09-26
Owner
  • Wilson Wolf Manufacturing (USA)
  • Baylor College of Medicine (USA)
Inventor
  • Vera, Juan F.
  • Rooney, Cliona M.
  • Leen, Ann M.
  • Wilson, John R.

Abstract

An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.

IPC Classes  ?

  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means

5.

Methods of cell culture for adoptive cell therapy

      
Application Number 18511208
Grant Number 11999969
Status In Force
Filing Date 2023-11-16
First Publication Date 2024-03-14
Grant Date 2024-06-04
Owner
  • Wilson Wolf Manufacturing (USA)
  • Baylor College of Medicine (USA)
Inventor
  • Vera, Juan F.
  • Rooney, Cliona M.
  • Leen, Ann M.
  • Wilson, John R.

Abstract

2.

IPC Classes  ?

  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means

6.

METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY

      
Application Number 18198708
Status Pending
Filing Date 2023-05-17
First Publication Date 2024-01-04
Owner Wilson Wolf Manufacturing (USA)
Inventor
  • Vera, Juan F.
  • Rooney, Cliona M.
  • Leen, Ann M.
  • Wilson, John R.

Abstract

Production and use of novel therapeutic cells, called T-Vehicles, in the allogeneic Adoptive Cell Therapy setting allows a wide range of therapeutic benefits to accrue with minimal or no risk of GVHD. T-Vehicles are created from donor T cells that are altered to contain therapeutic attributes that do not include their native antigen receptors and can deliver therapeutic benefits irrelevant of their native antigen specificity. T-Vehicles can possess highly restricted native antigen specificity that renders them unable to recognize antigens present on normal cells and incapable of initiating GVHD, making them ideal transport vehicles to deliver various therapeutic attributes in vivo. In essence, production and use of T-Vehicles is a paradigm shift that opens the door to therapeutic application of T cells in ways not previously contemplated, independent of whether or not there is an HLA match between the donor and the recipient.

IPC Classes  ?

  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
  • A61K 9/50 - Microcapsules
  • A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
  • A61K 51/08 - Peptides, e.g. proteins
  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

7.

METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY

      
Application Number 18198732
Status Pending
Filing Date 2023-05-17
First Publication Date 2023-11-30
Owner Wilson Wolf Manufacturing (USA)
Inventor
  • Vera, Juan F.
  • Rooney, Cliona M.
  • Leen, Ann M.
  • Wilson, John R.

Abstract

Production and use of novel therapeutic cells, called T-Vehicles, in the allogeneic Adoptive Cell Therapy setting allows a wide range of therapeutic benefits to accrue with minimal or no risk of GVHD. T-Vehicles are created from donor T cells that are altered to contain therapeutic attributes that do not include their native antigen receptors and can deliver therapeutic benefits irrelevant of their native antigen specificity. T-Vehicles can possess highly restricted native antigen specificity that renders them unable to recognize antigens present on normal cells and incapable of initiating GVHD, making them ideal transport vehicles to deliver various therapeutic attributes in vivo. In essence, production and use of T-Vehicles is a paradigm shift that opens the door to therapeutic application of T cells in ways not previously contemplated, independent of whether or not there is an HLA match between the donor and the recipient.

IPC Classes  ?

  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
  • A61K 9/50 - Microcapsules
  • A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
  • A61K 51/08 - Peptides, e.g. proteins
  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

8.

GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES

      
Application Number 18354308
Status Pending
Filing Date 2023-07-18
First Publication Date 2023-11-09
Owner
  • Baylor College of Medicine (USA)
  • Wilson Wolf Manufacturing (USA)
Inventor
  • Leen, Ann Marie
  • Gerdemann, Ulrike
  • Rooney, Cliona M.
  • Vera Valdes, Juan F.
  • Wilson, John R.

Abstract

The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.

IPC Classes  ?

  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 39/12 - Viral antigens
  • A61K 39/155 - Paramyxoviridae, e.g. parainfluenza virus
  • A61K 39/245 - Herpetoviridae, e.g. herpes simplex virus

9.

HIGHLY EFFICIENT GAS PERMEABLE DEVICES AND METHODS FOR CULTURING CELLS

      
Application Number 18202781
Status Pending
Filing Date 2023-05-26
First Publication Date 2023-09-28
Owner Wilson Wolf Manufacturing (USA)
Inventor Wilson, John R.

Abstract

This invention relates to methods and devices that improve cell culture efficiency. They include the use of gas permeable culture compartments that reduce the use of space while maintaining uniform culture conditions, and are more suitable for automated liquid handling. They include the integration of gas permeable materials into the traditional multiple shelf format to resolve the problem of non-uniform culture conditions. They include culture devices that use surfaces comprised of gas permeable, plasma charged silicone and can integrate traditional attachment surfaces, such as those comprised of traditional tissue culture treated polystyrene. They include culture devices that integrate gas permeable, liquid permeable membranes. A variety of benefits accrue, including more optimal culture conditions during scale up and more efficient use of inventory space, incubator space, and disposal space. Furthermore, labor and contamination risk are reduced.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/24 - Apparatus for enzymology or microbiology tube or bottle type

10.

HIGHLY EFFICIENT GAS PERMEABLE DEVICES AND METHODS FOR CULTURING CELLS

      
Application Number 18132235
Status Pending
Filing Date 2023-04-07
First Publication Date 2023-08-24
Owner Wilson Wolf Manufacturing (USA)
Inventor Wilson, John R.

Abstract

This invention relates to methods and devices that improve cell culture efficiency. They include the use of gas permeable culture compartments that reduce the use of space while maintaining uniform culture conditions, and are more suitable for automated liquid handling. They include the integration of gas permeable materials into the traditional multiple shelf format to resolve the problem of non-uniform culture conditions. They include culture devices that use surfaces comprised of gas permeable, plasma charged silicone and can integrate traditional attachment surfaces, such as those comprised of traditional tissue culture treated polystyrene. They include culture devices that integrate gas permeable, liquid permeable membranes. A variety of benefits accrue, including more optimal culture conditions during scale up and more efficient use of inventory space, incubator space, and disposal space. Furthermore, labor and contamination risk are reduced.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/24 - Apparatus for enzymology or microbiology tube or bottle type

11.

Cell culture methods and devices utilizing gas permeable materials

      
Application Number 16006318
Grant Number RE049293
Status In Force
Filing Date 2018-06-12
First Publication Date 2022-11-15
Grant Date 2022-11-15
Owner Wilson Wolf Manufacturing (USA)
Inventor
  • Wilson, John R.
  • Page, Douglas A.
  • Welch, Daniel
  • Robeck, Alison

Abstract

Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
  • C12M 1/24 - Apparatus for enzymology or microbiology tube or bottle type

12.

GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES

      
Application Number 17804239
Status Pending
Filing Date 2022-05-26
First Publication Date 2022-09-08
Owner
  • Baylor College of Medicine (USA)
  • Wilson Wolf Manufacturing (USA)
Inventor
  • Leen, Ann Marie
  • Gerdemann, Ulrike
  • Rooney, Cliona M.
  • Vera Valdes, Juan F.
  • Wilson, John R.

Abstract

The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.

IPC Classes  ?

  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 39/12 - Viral antigens
  • A61K 39/155 - Paramyxoviridae, e.g. parainfluenza virus
  • A61K 39/245 - Herpetoviridae, e.g. herpes simplex virus

13.

Methods of cell culture for adoptive cell therapy

      
Application Number 17688477
Grant Number 11821002
Status In Force
Filing Date 2022-03-07
First Publication Date 2022-06-16
Grant Date 2023-11-21
Owner
  • Baylor College of Medicine (USA)
  • Wilson Wolf Manufacturing (USA)
Inventor
  • Vera, Juan F.
  • Rooney, Cliona M.
  • Leen, Ann M.
  • Wilson, John R.

Abstract

2.

IPC Classes  ?

  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means

14.

Closed system device and methods for gas permeable cell culture process

      
Application Number 17477019
Grant Number 11873474
Status In Force
Filing Date 2021-09-16
First Publication Date 2022-01-06
Grant Date 2024-01-16
Owner Wilson Wolf Manufacturing (USA)
Inventor
  • Welch, Daniel P.
  • Wilson, John R.

Abstract

Novel methods and apparatus are disclosed for cell culture and cell recovery. The methods and apparatus simplify the process of cell separation from media, minimize potential damage to gas permeable devices during fluid handling, and allow closed system automated cell culture and cell recovery from gas permeable devices.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12Q 3/00 - Condition-responsive control processes
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors

15.

Methods of cell culture for adoptive cell therapy

      
Application Number 16696557
Grant Number 11268066
Status In Force
Filing Date 2019-11-26
First Publication Date 2020-03-26
Grant Date 2022-03-08
Owner
  • Wilson Wolf Manufacturing (USA)
  • Baylor College of Medicine (USA)
Inventor
  • Vera, Juan F.
  • Rooney, Cliona M.
  • Leen, Ann M.
  • Wilson, John R.

Abstract

2.

IPC Classes  ?

  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means

16.

Closed system device and methods for gas permeable cell culture process

      
Application Number 15726060
Grant Number 11155778
Status In Force
Filing Date 2017-10-05
First Publication Date 2018-02-08
Grant Date 2021-10-26
Owner Wilson Wolf Manufacturing (USA)
Inventor
  • Welch, Daniel P.
  • Wilson, John R.

Abstract

Novel methods and apparatus are disclosed for cell culture and cell recovery. The methods and apparatus simplify the process of cell separation from media, minimize potential damage to gas permeable devices during fluid handling, and allow closed system automated cell culture and cell recovery from gas permeable devices.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12Q 3/00 - Condition-responsive control processes
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors

17.

Methods of cell culture for adoptive cell therapy

      
Application Number 15395662
Grant Number 10533156
Status In Force
Filing Date 2016-12-30
First Publication Date 2017-09-21
Grant Date 2020-01-14
Owner
  • Baylor College of Medicine (USA)
  • Wilson Wolf Manufacturing (USA)
Inventor
  • Vera, Juan F.
  • Rooney, Cliona M.
  • Leen, Ann M.
  • Wilson, John R.

Abstract

2.

IPC Classes  ?

  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means

18.

Generation of CTL lines with specificity against multiple tumor antigens or multiple viruses

      
Application Number 15246241
Grant Number 10385316
Status In Force
Filing Date 2016-08-24
First Publication Date 2016-12-15
Grant Date 2019-08-20
Owner
  • Baylor College of Medicine (USA)
  • Wilson Wolf Manufacturing (USA)
Inventor
  • Leen, Ann Marie
  • Gerdemann, Ulrike
  • Rooney, Cliona M.
  • Vera Valdes, Juan F.
  • Wilson, John R.

Abstract

The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.

IPC Classes  ?

  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
  • A61K 38/00 - Medicinal preparations containing peptides
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • C12N 5/02 - Propagation of single cells or cells in suspensionMaintenance thereofCulture media therefor
  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • A61K 39/12 - Viral antigens
  • A61K 39/155 - Paramyxoviridae, e.g. parainfluenza virus
  • A61K 39/245 - Herpetoviridae, e.g. herpes simplex virus

19.

IMPROVED CULTURE METHODS AND DEVICES FOR TESTING

      
Application Number US2016031544
Publication Number 2016/183037
Status In Force
Filing Date 2016-05-09
Publication Date 2016-11-17
Owner WILSON WOLF MANUFACTURING (USA)
Inventor
  • Wilson, John, R.
  • Welch, Daniel, P.

Abstract

Improved cell culture devices and related methods that overcome the limitations of prior devices and methods, by creating devices that can integrate a variety of novel attributes. These various attributes include the use of gas permeable material and medium volumes that exceed conventional devices as well as compartments that can facilitate the long term study of high density cultures with reduced disruption of the culture environment, the ability to study the migration of items of interest including substances such as chemokine, track the movement of cells, and monitor cell to cell interactions.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

20.

Methods of genetically modifying animal cells

      
Application Number 14494300
Grant Number 10584354
Status In Force
Filing Date 2014-09-23
First Publication Date 2015-03-26
Grant Date 2020-03-10
Owner Wilson Wolf Manufacturing (USA)
Inventor Wilson, John R.

Abstract

The invention relates to improved methods of genetically modifying animal cells by decreasing the distance between cells and genetic modification agents in order to increase the number of cells modified by a given quantity of genetic modification agents and/or reduce the quantity of genetic modification agents needed to transduce a given number of cells.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
  • C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
  • C12N 15/86 - Viral vectors
  • C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

21.

Closed system device and methods for gas permeable cell culture process

      
Application Number 14313702
Grant Number 09840692
Status In Force
Filing Date 2014-06-24
First Publication Date 2014-12-25
Grant Date 2017-12-12
Owner Wilson Wolf Manufacturing (USA)
Inventor
  • Welch, Daniel P.
  • Wilson, John R.

Abstract

Novel methods and apparatus are disclosed for cell culture and cell recovery. The methods and apparatus simplify the process of cell separation from media, minimize potential damage to gas permeable devices during fluid handling, and allow closed system automated cell culture and cell recovery from gas permeable devices.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12Q 3/00 - Condition-responsive control processes
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors

22.

Methods of cell culture for adoptive cell therapy

      
Application Number 13475700
Grant Number 08956860
Status In Force
Filing Date 2012-05-18
First Publication Date 2013-04-25
Grant Date 2015-02-17
Owner WILSON WOLF MANUFACTURING (USA)
Inventor
  • Vera, Juan F.
  • Rooney, Cliona M.
  • Leen, Ann M.
  • Wilson, John R.

Abstract

2.

IPC Classes  ?

  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

23.

Generation of CTL lines with specificity against multiple tumor antigens or multiple viruses

      
Application Number 12862409
Grant Number 09963677
Status In Force
Filing Date 2010-08-24
First Publication Date 2011-07-28
Grant Date 2018-05-08
Owner
  • Baylor College of Medicine (USA)
  • Wilson Wolf Manufacturing (USA)
Inventor
  • Leen, Ann M.
  • Gerdemann, Ulrike
  • Rooney, Cliona M.
  • Vera, Juan
  • Wilson, John R.

Abstract

The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.

IPC Classes  ?

  • A61K 38/00 - Medicinal preparations containing peptides
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
  • C12N 5/02 - Propagation of single cells or cells in suspensionMaintenance thereofCulture media therefor
  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • A61K 39/12 - Viral antigens
  • A61K 39/155 - Paramyxoviridae, e.g. parainfluenza virus
  • A61K 39/245 - Herpetoviridae, e.g. herpes simplex virus
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

24.

GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES

      
Application Number US2010046505
Publication Number 2011/028531
Status In Force
Filing Date 2010-08-24
Publication Date 2011-03-10
Owner
  • BAYLOR COLLEGE OF MEDICINE (USA)
  • WILSON WOLF MANUFACTURING (USA)
Inventor
  • Leen, Ann Marie
  • Rooney, Cliona
  • Gerdemann, Ulrike
  • Vera, Juan

Abstract

The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.

IPC Classes  ?

  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

25.

Cell culture methods and devices utilizing gas permeable materials

      
Application Number 11505122
Grant Number 08415144
Status In Force
Filing Date 2006-08-16
First Publication Date 2007-11-01
Grant Date 2013-04-09
Owner Wilson Wolf Manufacturing (USA)
Inventor
  • Wilson, John R.
  • Page, Douglas A.
  • Welch, Dan
  • Robeck, Alison

Abstract

Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.

IPC Classes  ?

  • C12M 1/22 - Petri dishes
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus