A nest may have a horizontal base forming a plurality of openings and a plurality of tubular members extending downwardly from the horizontal base. Each of the tubular members may have a side wall defining a well in communication with an opening of the plurality of openings. In some embodiments, the side wall has a counterbore extending from the opening at an angle relative to a longitudinal axis of the tubular member, the counterbore having an inner surface defining a continuous circumference or perimeter. In some embodiments, the side wall has an inner surface with an upper portion defined by a series of radii of curvature providing a continuously curved surface extending from the opening and reducing a diameter of the well.
B65D 25/10 - Devices to locate articles in containers
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A nest may have a horizontal base forming a plurality of openings and a plurality of tubular members extending downwardly from the horizontal base. Each of the tubular members may have a side wall defining a well in communication with an opening of the plurality of openings. In some embodiments, the side wall has a counterbore extending from the opening at an angle relative to a longitudinal axis of the tubular member, the counterbore having an inner surface defining a continuous circumference or perimeter. In some embodiments, the side wall has an inner surface with an upper portion defined by a series of radii of curvature providing a continuously curved surface extending from the opening and reducing a diameter of the well.
This disclosure is directed to devices, systems, and methods for determining an amount of expansion or retraction of skin. The devices, systems, and methods can include a pattern that can be applied to a surface of the skin. The pattern can include repeating features. When the pattern is applied to the surface of the skin, each of the repeating features can move together with the skin and independently from each of the other repeating features of the pattern. The amount of expansion or retraction of the skin can be determined by comparing a first three-dimensional model of the pattern and a second three-dimensional model of the pattern formed using images and depth data captured at different times.
Computed tomography (CT) scanning while a part is maintained at low temperatures is described. A system includes a CT scan machine performing at least one 360° CT scan of the part. The system also includes a cooler to contain and maintain the part at the low temperature during the CT scans. The cooler includes a chamber and a cooling material provided within the chamber sufficient to maintain the part at the low temperature during the CT scans. The cooler includes a holder provided within the chamber that holds the part within a region of the chamber that substantially surrounds the part and that provides the CT scanner a 360-degree view of the part unobstructed by the cooling material.
G01N 23/046 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
G01B 5/00 - Measuring arrangements characterised by the use of mechanical techniques
G01B 15/00 - Measuring arrangements characterised by the use of electromagnetic waves or particle radiation, e.g. by the use of microwaves, X-rays, gamma rays or electrons
An injection device includes a connector body releasably attached to a syringe, a needle attached to a needle hub, and a rotary knob. The rotary knob rotates relative to the connector body to advance and/or retract the needle hub. The rotary knob may be configured to advance and/or retract the needle hub in discrete steps. At least one pin may connect the needle hub and the rotary knob, and the rotary knob may include at least one rotary slot receiving the at least one pin, and the at least one pin may rotationally fix the needle hub relative to connector body. A system including the injection device and a syringe releasably attachable to the injection device is also described. A method of assembling the injection device is further described.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/46 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for controlling depth of insertion
6.
SMART SYRINGE USING NFC COMMUNICATION AND CAPACITANCE DETECTION
A syringe system with NFC technology to detect and report state changes is described. The syringe system includes a plunger with sections of different materials, a barrel, and an inlay containing an NFC antenna and a microcontroller. The microcontroller measures capacitance changes between probes on the barrel, indicating plunger movement and position. The syringe system communicates real-time injection status to external devices, ensuring accurate medication administration. The flexible inlay can be over-molded or adhered to the syringe, adapting to various devices, including auto-injectors and manual self-injection systems. The technology supports real-time monitoring and accurate drug dosing.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/24 - Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A cap for crimping a stopper on a syringe and for fluidly connecting the syringe to an adapter is described. The cap includes a connector that connects to the syringe. The cap includes a spike movably disposed within the interior of the connector between a first position and a second position. The spike can abut against the adapter to fluidly connect to the adapter. When the connector is connected to the syringe and the spike is in the first position, a tip of the spike is spaced from an inner surface of the stopper. When the connector is connected to the syringe and the spike is in the second position, the tip of the spike extends through the stopper to fluidly connect the spike and an interior of the syringe.
17 - Rubber and plastic; packing and insulating materials
Goods & Services
Polymer film laminate sold as an integral part of plungers for medical syringes Polymer film laminate sold as an integral part of elastomer stoppers for pharmaceutical containers
WEST PHARMACEUTICAL SERVICES DEUTSCHLAND GMBH & CO. KG (Germany)
Inventor
Richlowski, Kolja
Abstract
Closure devices for sealing a container and systems and methods for sealing containers with the closure devices in parallel are disclosed. The closure device includes a stopper and a cap. The cap includes a ring, a crown, and a lid. The stopper and cap can be arranged in a preloaded position in which the stopper is partially inserted into an opening of the container and a sealed position in which the stopper seals the opening of the container and locks of the ring lock the cap to the container. A spring prevents the lid from engaging with surface of the crown when the sealing force moves the stopper and the cap between the preloaded position and the sealed position to provide a tolerance for compression beyond what is necessary to seal the container.
B65D 45/32 - Clamping or other pressure-applying devices for securing or retaining closure members for applying radial pressure, e.g. contractible bands encircling closure member
A syringe plunger rod includes a rod body having a proximal rod end and a distal rod end, where the distal rod end has a distal rod end circumference. The syringe plunger rod also includes a threaded extension extending distally from the distal rod end. The threaded extension includes at least one male thread extending from a thread shank, where the thread shank has a proximal thread shank end and a distal thread shank end. The proximal thread shank end has a diameter less than the diameter of the distal rod end circumference. The syringe plunger rod also includes an annular distal rod surface extending between the distal rod end circumference and the proximal male thread shank end.
An injection device can include a housing having a contact surface to contact the injection site. The device can include an ortho-planar spring configured to be moved between a resting configuration and a compressed configuration. A needle hub with a needle is attached to the ortho-planar spring. A needle guard can be moved between an extended configuration, in which the needle guard covers the needle tip, and a retracted configuration, in which the needle guard does not cover the needle tip. A retaining clip can prevent movement of the needle guard from the extended configuration to the retracted configuration. The ortho-planar spring can be compressed when the housing is placed on the injection site. The retaining clip can be deflected away from the needle guard to allow relative movement between the needle guard and the needle hub so that the needle guard is retracted.
An infusion pump assembly (1) includes a housing (14) with a fluid reservoir (18) and an opening (22) to receive a connector (100) of an infusion set to fluidly connect to the reservoir. The assembly includes a switch assembly (70) that transitions between a connected state when the connector is inserted within the opening and a disconnected state when the connector is removed from the opening. An infusion set connects to the infusion pump. The infusion set can have a connector having a body including an outer wall that defines an outer perimeter and a wall cross-sectional shape that corresponds with a cross-sectional shape of an opening of the housing.
Container systems including a syringe for containing bioink and for providing container closure integrity through cryogenic storage and warming are described. The syringe includes a barrel and a stopper that seals a proximal opening of the syringe. The syringe also includes a cap that is removably connected to a connector of the syringe at a distal end of the syringe and that seals a distal opening of the syringe. The syringe includes a piston within the barrel that can be spaced apart from the stopper when the barrel is filled with the bioink. The stopper and the cap can respectively seal the proximal and distal opening throughout a temperature range of between -196°C and 37°C.
Monitored pharmaceutical components, systems, and methods are described. The monitored pharmaceutical components include a body and electronics within the body. The electronics can detect forces acting on the monitored pharmaceutical component, generate data indicative of the forces over time, and transmit the data. The systems can also include a plurality of unmonitored pharmaceutical components. Each unmonitored pharmaceutical component can include a body that substantially corresponds to the body of the monitored pharmaceutical component. The system can also include a device external from the monitored pharmaceutical component. The device can receive, from the electronics of the monitored pharmaceutical component, the data. The device can predict, based on the data indicative of the forces acting on the monitored pharmaceutical component over time, degradation of the plurality of unmonitored pharmaceutical components.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes DetailsAccessories therefor
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
A method for manufacturing a syringe is described. The syringe includes a barrel having an open proximal end, a piston shaft having proximal and distal ends, and a piston having a longitudinal axis and opposing proximal and distal axial ends. Initially, a partially formed piston body is molded. The piston is then completely molded. The distal end of the piston shaft is engaged with the proximal axial end of the piston. The piston engaged with the piston shaft is received in the open proximal end of the barrel.
An injection device includes a housing and a drive spring within the housing. The drive spring has a distal end and a proximal end opposite the distal end along the longitudinal axis. The drive spring defines an interior cavity. A plunger is disposed at least partially within a medicament container and a plunger rod is engaged with the plunger. A drive-lock mechanism includes a latch mechanism at least partially received within the interior cavity. The lock mechanism includes at least one engagement portion that releasably engages the plunger rod. A retraction collar is engaged with the latch mechanism that moves from a drive-locked position, which prevents unlocking of the drive-lock mechanism, to a drive-unlocked position relative to the retraction collar, in which decoupling of the drive-lock mechanism is permitted. A method of manufacturing the injection device is also described.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
An injection device includes a housing defining a longitudinal axis and receiving a medicament container containing a medicament. The housing has a distal end which defines an opening for receiving a portion of a needle operably coupled with the medicament container. A safety shield surrounds at least a distal portion of the housing. The safety shield advances distally relative to the housing from a retracted position to a deployed position for shielding the needle. An advancement spring is arranged between the housing and the safety shield. The advancement spring advances the safety shield from the retracted position to the deployed position, and interlocks with the housing and the safety shield when the safety shield is in the deployed position to prevent return of the safety shield to the retracted position.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
An assembly for an injection device is described. The assembly includes a container containing the medicament and having a cap. The container is sealed by a septum. A sealing element is in contact with an external surface of the cap and a needle is provided for piercing the septum. A needle hub is attached to the needle, where the sealing element is disposed between the external surface of the cap of the container and an internal surface of the needle hub. The assembly transitions from a first state, in which the needle is held away from the septum and a free end of the needle sits in a cavity sealed by the sealing element, to a second state, in which the needle passes through the septum. The seal is maintained throughout transition and when the assembly is in the second state.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
An injection device includes a drive spring within the housing, a first drive component that transfers drive from the drive spring to a plunger disposed within a medicament container, and a damper concentrically arranged with respect to the first drive component. The damper is longitudinally fixed relative to the housing. The first drive component moves along the longitudinal axis relative to the damper under the influence of the drive spring. The damper frictionally engages a surface of the first drive component during movement of the drive component relative to the damper. A method of manufacturing the injection device is also described.
A vial adapter for a closure system having an elastomeric stopper and a cap is provided. The vial adapter includes a top wall, a connector extending therefrom in a first direction, and a cannula extending from the top wall in a second direction. The cannula includes a sharp distal tip for piercing the elastomeric stopper and providing for fluid communication between the vial adapter and the vial when the vial adapter is mounted to the vial. A skirt extends from the top wall and surrounds the cannula. The skirt includes at least one flexible retention arm having a retention latch for snap fitting to an underside portion of the cap of the closure system when the vial adapter is mounted to the vial. The cannula has a length from the top wall such that the sharp distal tip of the cannula is located proximal to the retention latch.
A microfluidic device may have at least one inlet channel: a microfluidic channel (214) having a first portion fluidly connected to the at least one inlet channel (210, 212); and at least one outlet channel (225a, 225b, 225c) fluidly connected to a second portion of the microfluidic channel, wherein the microfluidic channel has a plurality of dimples (220a, 220b, 220c) extending away from an axis of the microfluidic channel. The at least one inlet channel includes a first inlet channel and a second inlet channel, and/or the at least one outlet channel includes a first outlet channel and a second outlet channel. In some embodiments, the plurality of dimples may be configured to separate nanoparticles of different sizes to the first outlet channel and the second outlet channel.
B01D 43/00 - Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
Embodiments of an adapter (100), a system including the adapter, and methods of using the adapter may be for mixing a first substance and a second substance. The adapter (100) may include a body (101) having a first port (102) configured to connect with a first container to receive a first substance, a second port (104) configured to connect with a second container to receive a second substance, a third port (130) configured to connect with a recipient container to output a mixture of the first substance and the second substance, and a mixing chamber having a first portion in communication with the first port and the second port and a second portion in communication with the third port. The adapter may further include a mixing pin (160) inserted into the mixing chamber. In some embodiments, the mixing pin at least partially defines at least one microfluidic path for mixing the first substance and the second substance. In some embodiments, at least one of the first channel and the second channel are oriented offset of a central plane of the body.
Embodiments of an adapter, a system including the adapter, and methods of using the adapter may be for mixing a first substance and a second substance. The adapter may include a body having a first port configured to connect with a first container to receive a first substance, a second port configured to connect with a second container to receive a second substance, a third port configured to connect with a recipient container to output a mixture of the first substance and the second substance, and a mixing chamber having a first portion in communication with the first port and the second port and a second portion in communication with the third port. The adapter may further include a mixing pin inserted into the mixing chamber. In some embodiments, the mixing pin at least partially defines at least one microfluidic path for mixing the first substance and the second substance. In some embodiments, at least one of the first channel and the second channel are oriented offset of a central plane of the body.
Embodiments of an adapter, a system including the adapter, and methods of using the adapter may be for mixing a first substance and a second substance. The adapter may include a body having a first port configured to connect with a first container to receive a first substance, a second port configured to connect with a second container to receive a second substance, a third port configured to connect with a recipient container to output a mixture of the first substance and the second substance, and a mixing chamber having a first portion in communication with the first port and the second port and a second portion in communication with the third port. The adapter may further include a mixing pin inserted into the mixing chamber. In some embodiments, the mixing pin at least partially defines at least one microfluidic path for mixing the first substance and the second substance. In some embodiments, at least one of the first channel and the second channel are oriented offset of a central plane of the body.
A microfluidic device may have at least one inlet channel; a microfluidic channel having a first portion fluidly connected to the at least one inlet channel; and at least one outlet channel fluidly connected to a second portion of the microfluidic channel, wherein the microfluidic channel has a plurality of dimples extending away from an axis of the microfluidic channel. The at least one inlet channel includes a first inlet channel and a second inlet channel, and/or the at least one outlet channel includes a first outlet channel and a second outlet channel. In some embodiments, the plurality of dimples may be configured to separate nanoparticles of different sizes to the first outlet channel and the second outlet channel.
Small batch packaging for vial seals and vial stoppers is provided. The packaging includes a vial tray having a plurality of individual spaced-apart vial receptacles for receiving respective vials. The packaging also includes a vial seal tray having a plurality of individual spaced-apart seal receptacles for receiving respective vial seals. The packaging further includes a stopper tray having a plurality of individual spaced-apart stopper receptacles for receiving respective vial seals. A seal channel may extend through the plurality of individually spaced-apart seal receptacles to form a clearance for facilitating grasping of each vial seal. Similarly, a stopper channel may extend through the plurality of individually spaced-apart stopper receptacles to form a clearance for facilitating grasping of each vial stopper.
B65D 51/26 - Closures not otherwise provided for combined with auxiliary devices for non-closing purposes with means for keeping contents in position, e.g. resilient means
B65D 77/04 - Articles or materials enclosed in two or more containers disposed one within another
An infusion set adapter connects to an infusion set for delivering a medicament to an injection site from a medicament source. The infusion set adapter can include a housing a controller, a power source, and at least one sensor configured to detect a characteristic of the infusion set adapter, infusion set, infusion site, and/or the medicament source. The controller can process information received from the one or more sensors and cause an action to occur in response to the received and processed information. The housing can include a retention member to connect the infusion set adapter to the infusion set. An infusion set include components of the infusion adapter above integrated therein. Methods of operating infusion sets and infusion set adapters are also disclosed.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
30.
SYRINGE FOR GENERATING PARTICLE BASED FORMULATIONS
A syringe and associated methods for generating a particle-based formulation is described. The syringe includes a barrel with a microfluidic mixer, a seal, and piston. A displacement of the piston in a distal direction is configured to draw a first fluid from a first fluid source into a first chamber of the barrel and to draw a second fluid from a second fluid source into a second chamber of the barrel. A displacement of the piston in a proximal direction is configured to expel the first fluid and the second fluid respectively out of the first chamber and the second chamber and into the microfluidic mixer to mix the first and second fluid into the particle-based formulation.
There are provided devices and methods for the selective opening and closing of a medicament container using a valve structure. The valve structure may include a seal which is rotatable to selectively align an opening with a fluid path in a valve structure. By rotating the seal, a user may open a medicament container at the point of use, thereby maintaining sterility of one or more components of a medicament delivery device.
There are provided devices and methods for the selective opening and closing of a medicament container using a valve structure. The valve structure may include a seal which is rotatable to selectively align an opening with a fluid path in a valve structure. By rotating the seal, a user may open a medicament container at the point of use, thereby maintaining sterility of one or more components of a medicament delivery device.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
Connection systems for injection devices are disclosed. Also disclosed are injection devices and methods of using the same. A connection system includes a first and second connection assembly and a coupling assembly to secure the same. The first connection assembly connects to a medicament container, and the second connection assembly has a needle movable toward the medicament container. Removable flexible barriers are disposed on the first and second connection assemblies and can be removed once the connection assemblies are coupled together to form an aseptic connection between the two assemblies. The needle can be moved toward the medicament container to pierce a septum on the container to form a fluid communication between the container and the needle.
A plunger rod and plunger rod adapter are described. The plunger rod and plunger rod adapter axially move a piston within a syringe barrel without removably connecting to the piston and resist deformation forces applied to the piston. The plunger rod and plunger rod adapter include a distal end that abuts against the interior of the piston. The distal end defines a first portion having a first diameter and a second portion distal to the first portion. The second portion has a second diameter smaller than the first diameter. When the plunger rod is slid into the interior of the piston, the first portion contacts the proximal face of the piston and the second portion contacts the interior of the piston without removably connecting to the piston.
An injection device (10) includes a lower housing (18), a sleeve (32) supported by the lower housing, and a syringe spring (34) received within the sleeve. The spring supports a syringe (12). A needle guard (26) is proximally slidable relative to the lower housing from a first position, concealing the syringe needle (12b), to a second position. A needle guard spring (27) biases the needle guard distally relative to the lower housing. An upper housing (16) is distally slidable relative to the lower housing from a pre-use position to a dispensed position. Movement of the needle guard from the first position to the second position extends the distal tip of the needle distally beyond the needle guard by a first distance. Subsequent distal movement of the upper housing relative to the lower housing from the pre-use position toward the dispensed position advances the distal tip of the needle distally further beyond the needle guard by a second distance.
A61M 5/46 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for controlling depth of insertion
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
West Pharmaceutical Services Deutschland GMBH & Co. KG (Germany)
Inventor
Richlowski, Kolja
Lepley, Carrington
Abstract
A closure device for sealing a container includes a stopper and a cap assembly. The cap assembly is configured to surround both the stopper and a neck of the container in a sealed condition and includes a ring portion and a crown portion. The ring portion contains the stopper and includes a plurality of locking tabs. The crown includes a skirt telescopically mounted over the ring and configured to radially deflect the plurality of locking tabs inwardly under an annular collar of the container when the crown is axially displaced towards the neck of the container. A method of sealing containers using the closure device is also provided.
B65B 7/28 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
38.
AMPHIPHILIC INTERLAYERS FOR POLYMER BASED CONTAINERS
Layered polymer materials include a first layer including a first cyclic olefin polymer or a first cyclic olefin copolymer, a third layer including a second cyclic olefin polymer or a second cyclic olefin copolymer, and a second layer including an amphiphilic polymer having a hydrophilic component with a Hansen Solubility Parameter distance of 8 MPa1/2or greater from oxygen gas, while at the same time having a hydrophobic component with a Hansen Solubility Parameter distance of 8 MPa1/2or less from COC or COP. The second layer can be in contact with and be between the first layer and the third layer. The layered polymer material can be used to construct the body of a vial or a syringe. Methods of making the layered polymer material and kits containing the layered polymer material or containers having a body constructed from the layered polymer material are also described.
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
17 - Rubber and plastic; packing and insulating materials
20 - Furniture and decorative products
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
Goods & Services
Rubber bottle stoppers for containers for medical purposes; rubber bottle stoppers for use with pharmaceutical containers Corks for bottles; non-metal caps for bottles for medical use; non-metallic bottle stoppers not of glass or rubber for containers for medical purposes; non-metal caps for bottles for medical use, namely, for use on bottles for pharmaceuticals; non-metallic bottle stoppers not of glass or rubber for medical purposes, namely, stoppers for use with pharmaceutical containers Plastic safety caps for medicine containers
Kits comprised of plastic or glass medication containers for
commercial use, and closures for containers comprised of
synthetic rubber or a combination of metal and plastic; kits
comprised of plastic or glass medication containers for
commercial use, and stoppers of synthetic rubber (terms too
vague in the opinion of the International Bureau – Rule 13
(2) (b) of the Regulations); kits comprised of plastic or
glass medication containers for commercial use, and sealing
caps comprised of a combination of metal and plastic; kits
comprised of plastic or glass medication containers for
commercial use, stoppers of synthetic rubber, and sealing
caps comprised of a combination of metal and plastic (terms
too vague in the opinion of the International Bureau – Rule
13 (2) (b) of the Regulations).
e.g.,e.g., 7.4). The disclosure also provides for methods of lubricating a surface of a component with these lubricants and components having a surface coated with the lubricant.
A packaging system for sealing a medicine container having a filling opening with a stopper includes a container tray having a container cell for receiving and stabilizing the medicine container. A shuttle has an exterior surface and an interior surface. The interior surface is configured for releasably securing the stopper. The shuttle is configured to release the stopper into the fill opening upon application of a releasing force to the exterior surface of the shuttle. A shuttle tray has a shuttle cell. The shuttle cell forms a body with a proximal opening, an interior space, a bottom inner surface opposite the proximal opening, and a side inner surface. The shuttle cell releasably secures the shuttle.
B65B 7/28 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
B65D 71/50 - Bundles of articles held together by packaging elements for convenience of storage or transport, e.g. portable segregating carrier for plural receptacles such as beer cans or pop bottlesBales of material comprising a plurality of articles held together only partially by packaging elements formed otherwise than by folding a blank
B67B 1/04 - Closing bottles, jars, or similar containers by applying stoppers by inserting threadless stoppers, e.g. corks
44.
SYSTEMS, COMPOSITIONS AND METHODS FOR LOW TEMPERATURE PRESERVATION OF CELLS, BIOINKS, HYDROGELS, AND TISSUE ENGINEERED MEDICINAL PRODUCTS (TEMPS)
This disclosure provides cryoprotectant compositions containing one or more cryoprotective agents encapsulated by one or more stimulus-responsive nanoparticles or microparticles, kits containing the compositions, and methods of using the composition to, for example, bioprinting. The cryoprotectant compositions allow for the on-demand delivery of the cryoprotective agent by exposing the one or more stimulus-responsive nanoparticles or microparticles to a stimulus that results in the release of the cryoprotective agent in a location of interest. The one or more stimulus-responsive nanoparticles or microparticles can be formulated for entry into a cell or for preventing entry into a cell. Accordingly, the disclosure provides for on-demand delivery of a cryoprotective agent.
A container assembly for containing and delivering a medicament is described. The container assembly includes a container having a first end and a second end. The first end includes an opening, and a plunger assembly at least partially disposed in the container. The plunger assembly includes a main body and at least one resilient portion at least partially retained by a groove in the main body. The resilient portion forms a seal with the container. The plunger assembly forms a temperature resilient seal with the container such that the container assembly is operable to contain a medicament between the seal and the opening at: (a) room temperature, and (b) during freeze storage of the medicament. The plunger assembly is moveable relative to the container at room temperature.
A patch for sensing distinct conditions indicative of a physiological response is described. The patch includes a base for attaching to a region of skin undergoing a physiological response. The patch also includes a first sensor provided on the base that detects a first condition indicative of the physiological response of the region of skin, a second sensor provided on the base that detects a second condition indicative of the physiological response, and a third sensor provided on the base that detects a third condition indicative of the physiological response. The first sensor, the second sensor, and the third sensor are each distinct sensor modalities that detect distinct conditions.
A patch for sensing distinct conditions indicative of a physiological response is described. The patch includes a base for attaching to a region of skin undergoing a physiological response. The patch also includes a first sensor provided on the base that detects a first condition indicative of the physiological response of the region of skin, a second sensor provided on the base that detects a second condition indicative of the physiological response, and a third sensor provided on the base that detects a third condition indicative of the physiological response. The first sensor, the second sensor, and the third sensor are each distinct sensor modalities that detect distinct conditions.
Helium leak detection apparatus and method of helium leak detection are described. The apparatus is used with a container having a sealing member arranged to seal a first external access point. The apparatus includes a fitting that encloses at least a portion of the container and a holder that holds the sealing member of the container in place when a differential pressure is applied across the sealing member. The differential pressure can be applied across the seal to detect a fault in the seal.
G01M 3/20 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material
G01M 3/22 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables, or tubesInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipe joints or sealsInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for valves
Computed tomography (CT) scanning while a part is maintained at low temperatures is described. A system includes a CT scan machine performing at least one 360° CT scan of the part. The system also includes a cooler to contain and maintain the part at the low temperature during the CT scans. The cooler includes a chamber and a cooling material provided within the chamber sufficient to maintain the part at the low temperature during the CT scans. The cooler includes a holder provided within the chamber that holds the part within a region of the chamber that substantially surrounds the part and that provides the CT scanner a 360-degree view of the part unobstructed by the cooling material.
G01N 23/046 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
G01B 15/06 - Measuring arrangements characterised by the use of electromagnetic waves or particle radiation, e.g. by the use of microwaves, X-rays, gamma rays or electrons for measuring the deformation in a solid
Kits comprised of plastic or glass medication containers for
commercial use, and closures for containers comprised of
synthetic rubber or a combination of metal and plastic; kits
comprised of plastic or glass medication containers for
commercial use, and stoppers of synthetic rubber; kits
comprised of plastic or glass medication containers for
commercial use, and sealing caps comprised of a combination
of metal and plastic; kits comprised of plastic or glass
medication containers for commercial use, stoppers of
synthetic rubber, and sealing caps comprised of a
combination of metal and plastic.
52.
CONTAINER ASSEMBLIES FOR CONTAINING AND DELIVERING MEDICAMENTS, AND METHODS OF FILLING SUCH ASSEMBLIES
A container assembly for containing and delivering a medicament, the container assembly comprising: a container having a first end and a second end, the first end comprising an opening; and a plunger assembly at least partially disposed in the container, the plunger assembly comprising: a main body; and at least one resilient portion at least partially retained by a groove in the main body and forming a seal with the container; and wherein the plunger assembly is configured to: form a temperature resilient seal with the container such that the container assembly is operable to contain a medicament between the seal and the opening at: (a) room temperature, and (b) during freeze storage of the medicament; and be moveable relative to the container at room temperature.
An injection device comprises a housing, a cartridge defining a chamber configured to hold a medicament, a plunger disposed within the chamber, and a plunger actuation assembly configured to drive the plunger. The injection device also comprises a power source configured to drive the plunger actuation assembly such that the plunger forces the medicament from the chamber a first disengagement element translationally fixed relative to the plunger actuation assembly, and a second disengagement element coupled to the plunger actuation assembly and to the power source, where the second disengagement element is translationally fixed relative to the plunger actuation assembly. The first disengagement element is configured to translationally decouple from the plunger actuation assembly when the power source drives the plunger actuation assembly a first distance, and translationally decouple the second disengagement element from the plunger actuation assembly when the power source drives the plunger actuation assembly a second distance.
Systems and methods for drug delivery are disclosed in which an injection device comprises a parenteral interface, comprising a support and a needle assembly, suspended within a cavity in a housing of the device such that the parenteral interface is movably mounted with respect to the housing when the needle assembly is in the injection position. The parenteral interface can be configured to allow movement of the housing of the device with respect to the skin without displacing the needle assembly. The devices can be configured to passively or actively compensate for movement of the housing relative to the injection site to ensure correct delivery depth is maintained during time device is worn. For example, by mounting the support of the parenteral interface on a deformable mount or an articulated or rotatable component.
An adapter for connecting one or more storage containers with a syringe is described. The adapter includes a first port that provide a connection with a first container volume, a second port that provides a connection with a second container volume, a third port that provides a connection to a syringe. The adapter further includes a mixing channel extending from a first end in fluid communication with the third port to a second end. The mixing channel includes a tortuous path along at least a portion of its length. The mixing channel enables two constituents of a pharmaceutical complex to be mixed through the mixing channel to form the pharmaceutical complex. Also disclosed is a system including such an adapter, a method of mixing two constituents of a pharmaceutical complex via such an adapter and a method of manufacturing such an adapter.
B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
56.
ADAPTER AND METHOD OF MIXING CONSTITUENTS OF A PHARMACEUTICAL COMPLEX VIA AN ADAPTER
An adapter for connecting one or more storage containers with a syringe is described. The adapter includes a first port that provide a connection with a first container volume, a second port that provides a connection with a second container volume, a third port that provides a connection to a syringe. The adapter further includes a mixing channel extending from a first end in fluid communication with the third port to a second end. The mixing channel includes a tortuous path along at least a portion of its length. The mixing channel enables two constituents of a pharmaceutical complex to be mixed through the mixing channel to form the pharmaceutical complex. Also disclosed is a system including such an adapter, a method of mixing two constituents of a pharmaceutical complex via such an adapter and a method of manufacturing such an adapter.
B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
An adapter for connecting one or more storage containers with a syringe is described. The adapter includes a first port that provide a connection with a first container volume, a second port that provides a connection with a second container volume, a third port that provides a connection to a syringe. The adapter further includes a mixing channel extending from a first end in fluid communication with the third port to a second end. The mixing channel includes a tortuous path along at least a portion of its length. The mixing channel enables two constituents of a pharmaceutical complex to be mixed through the mixing channel to form the pharmaceutical complex. Also disclosed is a system including such an adapter, a method of mixing two constituents of a pharmaceutical complex via such an adapter and a method of manufacturing such an adapter.
B01F 33/301 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
B01F 23/45 - Mixing liquids with liquidsEmulsifying using flow mixing
A parenteral injection device comprises a housing defining an internal cavity and an output, a first reservoir disposed within the internal cavity, where the first reservoir defines a first chamber that is configured to store a drug and is in fluid communication with the output, a first drive mechanism to selectively force the drug from the first chamber, and a second reservoir disposed within the internal cavity, wherein the second reservoir defines a second chamber that is configured to store a gas and is in fluid communication with the output. The injection device further comprises a second drive mechanism to selectively force the gas from the second chamber, and a controller in signal communication with the first and second drive mechanisms, such that the controller is configured to selectively direct the first and second drive mechanisms to force the drug and gas from the first and second chambers, respectively, to the output in a predetermined sequence.
Various systems for the containment or delivery of a product are provided. The systems allow for the storage of products at low temperatures and include a container closure inserted into a container (10). The container closure may have an elastomeric body (12) and include a material (14) having a negative coefficient of thermal expansion. In other systems, the material having a negative coefficient of thermal expansion may be inserted between the elastomeric container closure and a seal. Other systems may include an insert at least partially embedded within the elastomeric body of a container closure, an actuator having a distal end movably attached to the insert, and a resilient element between the distal end of the actuator and the insert, wherein the resilient material expands radially upon displacing the distal end of the actuator toward the insert.
A method of manufacturing a medical component includes molding a first member of the medical component from an elastomeric material. The first member includes a first end defined by a closed base wall, an opposing second end which is an open end, a sidewall extending between the first and second ends, and an internal recess to receive at least one electronic device. The method further includes positioning the electronic device within the recess of the first member to form an assembly, such that the electronic device is received in an inverted open cavity defined by the sidewall. The method further includes applying a protective film on the second end of the first member, such that the protective film covers an exposed surface of the electronic device. In addition, the method includes overmolding the assembly with the elastomeric material to form the medical component having the electronic device embedded therein.
B29C 45/14 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mouldApparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes DetailsAccessories therefor
B29B 13/04 - Conditioning or physical treatment of the material to be shaped by cooling
B29C 43/18 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. compression moulding around inserts or for coating articles
A system for manufacturing elastomeric components is provided. The system may include a molding station having a mold configured to receive an elastomeric material, form a pad that includes a plurality of untrimmed elastomeric components, and cure the pad. The system may further include an automated marking station comprising a laser and a camera. The automated marking station may be configured to remove the cured pad from the molding station, present the cured pad to the laser to form a mark on each of the untrimmed elastomeric components, and present the cured pad to the camera to capture an image of each mark. A process for manufacturing the elastomeric components is also provided.
G06K 7/14 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
A syringe safety system may include a sleeve. The sleeve may include a guide track formed in the sleeve. The guide track may have a guide pin retention portion, a travel portion, and a lockout portion. The syringe safety system may include a collar having a guide from an exterior surface of the collar. A spring may extend between and be coupled to the collar and the sleeve. A cap may engage the sleeve. The cap may be configured to retain the guide pin in the guide pin retention portion of the guide tack. When the cap is removed, the spring advances the guide pin into the travel portion of the guide track.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
F16B 21/18 - Means without screw-thread for preventing relative axial movement of a pin, spigot, shaft, or the like and a member surrounding itStud-and-socket releasable fastenings without screw-thread by separate parts with grooves or notches in the pin or shaft with circlips or like resilient retaining devicesMeans without screw-thread for preventing relative axial movement of a pin, spigot, shaft, or the like and a member surrounding itStud-and-socket releasable fastenings without screw-thread by separate parts with grooves or notches in the pin or shaft Details
An infusion pump assembly (1) includes a housing (14) with a fluid reservoir (18) and an opening (22) to receive a connector (100) of an infusion set to fluidly connect to the reservoir. The assembly includes a switch assembly (70) that transitions between a connected state when the connector is inserted within the opening and a disconnected state when the connector is removed from the opening. An infusion set connects to the infusion pump. The infusion set can have a connector having a body including an outer wall that defines an outer perimeter and a wall cross-sectional shape that corresponds with a cross-sectional shape of an opening of the housing.
A device and method for measuring a volume of liquid expelled from a syringe is provided. The device generally includes a syringe barrel, a plunger actuated with a plunger rod, and a sensor. The sensor may include two ports with one port being in fluid communication with a source of fluid external to the syringe barrel, while the second port is in fluid communication either with a proximal end portion of the syringe barrel or a hollow plunger rod having a first end closed by the plunger. The method may include expelling liquid from the syringe; detecting and recording differential pressure with the sensor over time; and calculating the volume of liquid expelled from the syringe from the recorded differential pressure over time.
G01F 1/36 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure the pressure or differential pressure being created by the use of flow constriction
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/48 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for varying, regulating, indicating or limiting injection pressure
06 - Common metals and ores; objects made of metal
10 - Medical apparatus and instruments
17 - Rubber and plastic; packing and insulating materials
20 - Furniture and decorative products
39 - Transport, packaging, storage and travel services
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
45 - Legal and security services; personal services for individuals.
Goods & Services
Metal closures for containers; sealing caps of metal for use
in containers for medication. Droppers for administering medication, sold empty; medical
apparatus, namely, infusion and injection devices for
administering drugs and structural parts and replacement
parts therefor; medical syringes; baby bottle nipples;
safety fittings for medical injection devices for
administering drugs. Rubber and synthetic rubber stoppers for pharmaceutical
containers; non-metal seals for use on containers; rubber
stoppers for pharmaceutical containers. Non-metallic closures for containers; plastic vials and
containers for medications, sold empty, for commercial use;
plastic containers for packaging; packaging containers of
plastic; bottle closures not of metal; non-metal bottle
caps; container closures of plastic; plastic caps;
non-metallic closures for containers; plastic vials and
containers for medications, sold empty; stoppers, not of
glass, metal or rubber, for bottles, vials and
pharmaceutical containers; containers, not of metal for
commercial use, namely, plastic containers and closures
therefor for use in the pharmaceutical and cosmetics
industries. Packaging articles to the order and specification of others;
technical consulting in the field of drug packaging,
containment, and delivery services; consulting services for
others in the field of distribution in the nature of
delivery of drug packaging, containment, and delivery
systems. Contract manufacturing in the field of healthcare products,
drug delivery systems, medical diagnostic kits, and
pharmaceutical containers and closures; injection molding of
plastic of others; custom manufacture of molds for use in
industry; assembly of products for others in the nature of
custom manufacturing of drug packaging, containment, and
delivery systems; prototype fabrication of new products for
others; consulting services for others in the field of
custom manufacture of drug packaging, containment, and
delivery systems. Research and development and consultation related thereto in
the fields of drug packaging, containment, and delivery;
materials testing and evaluation; technical consulting in
the field of drug packaging design; quality control of goods
and services; consulting services for others in the field of
design and planning of integrated solutions for drug
packaging, containment, and delivery systems. Regulatory compliance consulting in the field of drug
packaging, containment, and delivery.
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
45 - Legal and security services; personal services for individuals.
Goods & Services
Custom manufacturing for others of drug packaging,
containment, and delivery systems; providing technical
advice relating to custom manufacture of drug packaging,
containment, and delivery systems; consulting services for
others in the field of custom manufacture of drug packaging,
containment, and delivery systems. Technical consulting in the field of drug packaging design;
research, development, engineering and testing services in
the field of drug packaging, containment, and delivery;
quality control of goods and services; consulting services
for others in the field of design and planning of integrated
solutions for drug packaging, containment, and delivery
systems. Regulatory compliance consulting in the field of drug
packaging, containment, and delivery.
Kits primarily comprised of non-metal medication containers, sold empty for commercial use, and secondarily comprised of non-metal and non-paper closures therefor; Kits primarily comprised of non-metal medication containers, sold empty for commercial use, and secondarily comprised of synthetic rubber stoppers being closures; Kits primarily comprised of non-metal medication containers, sold empty for commercial use, and secondarily comprised of stoppers being closures comprised of a combination of metal and plastic; Kits primarily comprised of non-metal medication containers, sold empty for commercial use, and secondarily comprised of seals being non-metal closures therefor and sealing caps comprised of a combination of metal and plastic; Kits primarily comprised of non-metal medication containers, sold empty for commercial use, and secondarily comprised of stoppers and seals being closures therefor in the nature of sealing caps comprised of a combination of metal and plastic
Kits primarily comprised of non-metal medication containers, sold empty for commercial use, and secondarily comprised of non-metal and non-paper closures therefor; Kits primarily comprised of non-metal medication containers, sold empty for commercial use, and secondarily comprised of synthetic rubber stoppers being closures; Kits primarily comprised of non-metal medication containers, sold empty for commercial use, and secondarily comprised of stoppers being closures comprised of a combination of metal and plastic; Kits primarily comprised of non-metal medication containers, sold empty for commercial use, and secondarily comprised of seals being non-metal closures therefor and sealing caps comprised of a combination of metal and plastic; Kits primarily comprised of non-metal medication containers, sold empty for commercial use, and secondarily comprised of stoppers and seals being closures therefor in the nature of sealing caps comprised of a combination of metal and plastic.
71.
Display screen or portion thereof with graphical user interface
A primary container assembly includes a primary container defining a body having a proximal end defining an opening configured to receive a plunger, a distal end opposite the proximal end and defining an outlet, and a chamber extending from the proximal end to the distal end that is configured to receive a drug. The primary container assembly further comprises a tube extending from a first end that is integrally attached to the distal end of the primary container to a second end opposite the first end, where the tube defines a channel extending from the first end to the second end. The primary container assembly also includes a hollow needle configured to penetrate skin of a patient.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/34 - Constructions for connecting the needle
Systems and methods for medical device usage management are disclosed. In an example method, an indication that an injection was administered to a patient by a medical device can be received. The indication may be received wirelessly from the medical device. One or more measurements of a physiological characteristic of the patient captured by a sensor associated with the patient can also be received. The indication that the injection was administered to the patient by the injector and the one or more measurements of the physiological characteristic of the patient can then be transmitted.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
74.
NEEDLE PROTECTION DEVICE COMPRISING SYRINGE CENTRING FEATURES AND DISASSEMBLY LOCK
A safety device for a syringe is described. The safety device includes a housing having a main body that receives a syringe, a flange support that supports a flange of the syringe, and prevents or limits distal movement of the syringe relative to the housing, a needle shield including a sleeve telescopically arranged with respect to the housing such that the needle shield can slide over the housing between an extended position in which a needle tip is covered and a retracted position in which the needle tip is exposed. The device also includes syringe centering features and/or a disassembly lock.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
An injection device includes a lower housing, a needle guard and an upper housing. With the upper housing in a pre-use position and the needle guard in a first position, an abutment body of an arm of the upper housing abuts a catch of the lower housing, preventing the upper housing from moving distally relative to the lower housing toward a dispensed position. Proximal movement of the needle guard from the first position to a second position thereof causes proximal movement of a camming ramp of a leg of the needle guard with respect to the catch and the abutment body such that the camming ramp engages the arm, thereby deflecting the abutment body radially outwardly by a distance sufficient to allow the abutment body to pass radially outside of the catch, and, in turn, permits the distal movement of the upper housing into the dispensed position of the upper housing.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
An injection device includes a drive spring within the housing, a first drive component that transfers drive from the drive spring to a plunger disposed within a medicament container, and a damper concentrically arranged with respect to the first drive component. The damper is longitudinally fixed relative to the housing. The first drive component moves along the longitudinal axis relative to the damper under the influence of the drive spring. The damper frictionally engages a surface of the first drive component during movement of the drive component relative to the damper. A method of manufacturing the injection device is also described.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
An assembly for an injection device is described. The assembly includes a container containing the medicament and having a cap. The container is sealed by a septum. A sealing element is in contact with an external surface of the cap and a needle is provided for piercing the septum. A needle hub is attached to the needle, where the sealing element is disposed between the external surface of the cap of the container and an internal surface of the needle hub. The assembly transitions from a first state, in which the needle is held away from the septum and a free end of the needle sits in a cavity sealed by the sealing element, to a second state, in which the needle passes through the septum. The seal is maintained throughout transition and when the assembly is in the second state.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/24 - Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
An injection device includes a housing and a drive spring within the housing. The drive spring has a distal end and a proximal end opposite the distal end along the longitudinal axis. The drive spring defines an interior cavity. A plunger is disposed at least partially within a medicament container and a plunger rod is engaged with the plunger. A drive-lock mechanism includes a latch mechanism at least partially received within the interior cavity. The lock mechanism includes at least one engagement portion that releasably engages the plunger rod. A retraction collar is engaged with the latch mechanism that moves from a drive-locked position, which prevents unlocking of the drive-lock mechanism, to a drive-unlocked position relative to the retraction collar, in which decoupling of the drive-lock mechanism is permitted. A method of manufacturing the injection device is also described.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
An injection device includes a housing defining a longitudinal axis and receiving a medicament container containing a medicament. The housing has a distal end which defines an opening for receiving a portion of a needle operably coupled with the medicament container. A safety shield surrounds at least a distal portion of the housing. The safety shield advances distally relative to the housing from a retracted position to a deployed position for shielding the needle. An advancement spring is arranged between the housing and the safety shield. The advancement spring advances the safety shield from the retracted position to the deployed position, and interlocks with the housing and the safety shield when the safety shield is in the deployed position to prevent return of the safety shield to the retracted position.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A medication administering device includes upper and lower housings. The lower housing supports a syringe having a needle. A needle guard is in sliding engagement with the lower housing and is proximally movable from a first position, wherein the needle guard conceals a tip of the needle, to a second position, wherein the needle guard exposes the tip of the needle. The upper housing is configured to receive a distally directed force and move relative to the lower housing from a pre-use position to a dispensed position in response to the manual force. When the upper housing is in the pre-use position and the needle guard is in the first position, the upper housing cannot move toward the dispensed position. Proximal movement of the needle guard from the first position to the second position frees the upper housing for movement to the dispensed position in response to the force.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A drive unit for an injector includes an elastomeric drive member configured to possess a first elastic potential energy in an elastically stretched state that is releasable to convert the elastic energy to a first biasing force. A selectively releasable plunger rod has a locked position maintaining the elastomeric drive member in the elastically stretched state. A trigger member is biased by a second biasing force into an interlocking position. In the interlocking position, an arm of the trigger member interlocks with a notch of the plunger rod, thereby maintaining the plunger rod in the locked position thereof. The trigger member is selectively movable against the second biasing force to an unlocking position spaced from the notch, thereby releasing the first elastic potential energy into the first biasing force to axially advance the plunger rod and thus advance the piston through the reservoir.
A method and system for creating an aseptic connection is disclosed. The method includes arranging a heating element between a first outer sealing surface and a second outer sealing surface such that the heating element is in contact with the first outer sealing surface and the second outer sealing surface. The method further includes applying opposing forces to the first and second outer sealing surfaces such that the first and second outer sealing surfaces are biased towards each other and heating the heating element to sterilize the first outer sealing surface and second outer sealing surface. The method also includes removing the heating element from between the first seal and second seal while continuing to apply the opposing forces to the first and second outer sealing surfaces such that the aseptic connection is simultaneously formed between the first and second outer sealing surfaces.
A drive unit for an injector includes an elastomeric drive member configured to possess a first elastic potential energy in an elastically stretched state that is releasable to convert the elastic energy to a first biasing force. A selectively releasable plunger rod has a locked position maintaining the elastomeric drive member in the elastically stretched state. A trigger member is biased by a second biasing force into an interlocking position. In the interlocking position, an arm of the trigger member interlocks with a notch of the plunger rod, thereby maintaining the plunger rod in the locked position thereof. The trigger member is selectively movable against the second biasing force to an unlocking position spaced from the notch, thereby releasing the first elastic potential energy into the first biasing force to axially advance the plunger rod and thus advance the piston through the reservoir.
A method and system for creating an aseptic connection is disclosed. The method includes arranging a heating element between a first outer sealing surface and a second outer sealing surface such that the heating element is in contact with the first outer sealing surface and the second outer sealing surface. The method further includes applying opposing forces to the first and second outer sealing surfaces such that the first and second outer sealing surfaces are biased towards each other and heating the heating element to sterilize the first outer sealing surface and second outer sealing surface. The method also includes removing the heating element from between the first seal and second seal while continuing to apply the opposing forces to the first and second outer sealing surfaces such that the aseptic connection is simultaneously formed between the first and second outer sealing surfaces.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/44 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for cooling or heating the devices or media
A piston having a longitudinal axis and opposing proximal and distal axial ends is manufactured by a method including molding a partially formed piston body and then molding the piston. The partially formed piston body is molded by placing a first rubber sheet and an inert film between die plates of a first forming tool, vulcanizing the first rubber sheet and the inert film between the die plates of the first forming tool, and blanking out the partially formed piston body from the first rubber sheet and the inert film. The piston is then molded by placing the partially formed piston body into a second forming tool, placing a second rubber sheet into the second forming tool, vulcanizing the second rubber sheet and the partially formed piston body together, and blanking out the piston from the second rubber sheet at a trim edge spaced apart from the inert film.
A piston to be provided within an inner wall of a barrel of a pharmaceutical syringe for dispensing medicament retained in the barrel is described. The piston includes a body defining a central face, a cylindrical portion, and an annular curved portion between the cylindrical portion and the central face portion. The piston also includes an inert film enclosing the central face portion and at least a part of the annular curved portion. The cylindrical portion and the part of the annular curved portion are together configured to maintain a fluid-tight seal with the inner wall of the barrel. A pharmaceutical syringe is described for dispensing a medicament includes a barrel configured to retain the medicament and the piston.
Conducting an on-line trade show exhibition, in the field of
healthcare products and services; conducting an on-line
trade show exhibition, in the field of drug delivery
systems, drug reconstitution and transfer systems,
containers and closures for pharmaceuticals and biologics,
and related packaging, analytical, regulatory and contract
manufacturing services; advertising on the internet for
others; providing an on-line commercial information
directory on the internet.
A container for storing a pharmaceutical composition includes a body portion having an elastomeric material, and an inner lining having a thermoplastic material covering at least a portion of an inner surface of the body portion. The container forms an internal chamber for storing the pharmaceutical composition, where the internal chamber is bounded by the inner surface of the body portion. The inner lining provides a barrier between the elastomeric material and the pharmaceutical composition, thus protecting the pharmaceutical composition. Associated methods of storing the pharmaceutical composition within the container, as well as manufacturing the container, are also described.
A container for storing a pharmaceutical composition includes a body portion having an elastomeric material, and an inner lining having a thermoplastic material covering at least a portion of an inner surface of the body portion. The container forms an internal chamber for storing the pharmaceutical composition, where the internal chamber is bounded by the inner surface of the body portion. The inner lining provides a barrier between the elastomeric material and the pharmaceutical composition, thus protecting the pharmaceutical composition. Associated methods of storing the pharmaceutical composition within the container, as well as manufacturing the container, are also described.
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
A vial closure assembly for sealing a container includes a ring, a cap, a shell, and an optional cover. The ring has a first top wall defining a first through-opening and a skirt extending downwardly from the first top wall that includes a plurality of locking tabs. The cover includes a second top wall defining a second through-opening, a sidewall extending downwardly from the second top wall, and an interior cavity defined by the second top wall and the sidewall. The cap includes a plurality of tabs configured to engage the first or second top wall. The shell includes a body having an inwardly radially extending upper and lower lip. The upper lip includes at least one rail for sliding contact with a top surface of either the first or second top wall.
An elastomeric article for sealing a container includes an elastomeric body having an external sidewall surface and an external crown surface and a first fluoropolymer film layer having an internal surface and an external surface. The internal surface of the first fluoropolymer film layer is laminated to an entirety of the external sidewall and crown surfaces of the elastomeric body. The external crown surface of the first fluoropolymer film layer includes a drug contact surface configured to contact a drug contained in the container and the external sidewall surface including a sealing surface for contacting an interior surface of the container. The external surface of the first fluoropolymer film layer is substantially free of striations.
B32B 38/10 - Removing layers, or parts of layers, mechanically or chemically
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
B29C 43/00 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor
B29C 43/02 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles
B29C 43/20 - Making multilayered or multicoloured articles
B29C 65/00 - Joining of preformed partsApparatus therefor
B29C 65/70 - Joining of preformed partsApparatus therefor by moulding
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
B32B 27/26 - Layered products essentially comprising synthetic resin characterised by the use of special additives using curing agents
B32B 37/00 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
B32B 37/26 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with at least one layer which influences the bonding during the laminating process, e.g. release layers or pressure equalising layers
Various container assemblies for containing a therapeutic liquid are provided. A first container assembly comprises a frame having a proximal end and a distal end and includes a plurality of axially extending legs, a collar attached to the plurality of axially extending legs at the proximal end of the frame, and a collapsible film covering the frame and attached to the distal end of the frame and at least a portion of the collar. A second container assembly for a therapeutic liquid comprises a collar and a collapsible film. The collar may comprise a plurality of hingedly connected segments configured to switch from an open configuration to a closed configuration. The collapsible film may be configured as a pouch having an open end attached to one end of the collar.
Small batch packaging for vial seals and vial stoppers is provided. The packaging includes a vial tray having a plurality of individual spaced-apart vial receptacles for receiving respective vials. The packaging also includes a vial seal tray having a plurality of individual spaced-apart seal receptacles for receiving respective vial seals. The packaging further includes a stopper tray having a plurality of individual spaced-apart stopper receptacles for receiving respective vial seals. A seal channel may extend through the plurality of individually spaced-apart seal receptacles to form a clearance for facilitating grasping of each vial seal. Similarly, a stopper channel may extend through the plurality of individually spaced-apart stopper receptacles to form a clearance for facilitating grasping of each vial stopper.
Systems and methods for determining Container Closure Integrity (CCI) in a container system comprising a container, an elastomeric stopper, and a retainer for retaining the stopper in place are disclosed. The systems and methods involve disposing, within a seal assembly, a component configured to sense a degree of compression of the elastomeric stopper. In a first implementation, the elastomeric stopper comprises an embedded positioning component embedded within the elastomeric material. The position of the positioning component is sensed using a detection system and the integrity of the closure is determined based on the position of the embedded component. In a second implementation, a force sensitive resistor is disposed within the seal stack to measure the compression of the elastomeric stopper. The compression of the elastomeric stopper is correlated to the integrity of the seal.
G01M 3/32 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators
B65D 55/02 - Locking devicesMeans for discouraging or indicating unauthorised opening or removal of closure
97.
Syringe housing of a syringe injection safety device
Connection systems for injection devices are disclosed. Also disclosed are injection devices and methods of using the same. A connection system includes a first and second connection assembly and a coupling assembly to secure the same. The first connection assembly connects to a medicament container, and the second connection assembly has a needle movable toward the medicament container. Removable flexible barriers are disposed on the first and second connection assemblies and can be removed once the connection assemblies are coupled together to form an aseptic connection between the two assemblies. The needle can be moved toward the medicament container to pierce a septum on the container to form a fluid communication between the container and the needle.
An injection device (10) includes a lower housing (18), a sleeve (32) supported by the lower housing, and a syringe spring (34) received within the sleeve. The spring supports a syringe (12). A needle guard (26) is proximally slidable relative to the lower housing from a first position, concealing the syringe needle (12b), to a second position. A needle guard spring (27) biases the needle guard distally relative to the lower housing. An upper housing (16) is distally slidable relative to the lower housing from a pre-use position to a dispensed position. Movement of the needle guard from the first position to the second position extends the distal tip of the needle distally beyond the needle guard by a first distance. Subsequent distal movement of the upper housing relative to the lower housing from the pre-use position toward the dispensed position advances the distal tip of the needle distally further beyond the needle guard by a second distance.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/46 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for controlling depth of insertion
