Medical devices for use in treating or diagnosing the relief of constipation and other disorders in the digestive tract of human beings via a capsule containing a mechanical stimulation mechanism.
Medical devices for use in treating or diagnosing the relief of constipation and other disorders in the digestive tract of human beings via a capsule containing a mechanical stimulation mechanism
3.
GASTROINTESTINAL TREATMENT SYSTEM INCLUDING A PERSONALIZED VIBRATING CAPSULE, AND METHOD OF USE THEREOF
A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitator, powered by the battery, the vibrating agitator adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitator; and (d) a controller adapted, in response to receipt of an activation input, to activate the vibrating agitator to operate in the first vibrating mode of operation at a user-specific time of day.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
4.
VIBRATING CAPSULE SYSTEMS AND TREATMENT METHODS USING SAME
A vibrating gastrointestinal capsule and method of use thereof for treating Parkinsonism in a subject, the method including: (a) providing a vibrating gastrointestinal capsule having a housing; a vibrating agitation mechanism adapted such that, in a vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; and a power supply disposed within the housing and adapted to power the vibrating agitation mechanism; (b) ingesting the capsule, by the subject; and (c) controlling the vibrating agitation mechanism such that at least a portion of the vibrating mode of operation occurs within the stomach and/or the small intestine of the subject.
A vibrating gastrointestinal capsule and method of use thereof for treating Parkinsonism in a subject, the method including: (a) providing a vibrating gastrointestinal capsule having a housing; a vibrating agitation mechanism adapted such that, in a vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; and a power supply disposed within the housing and adapted to power the vibrating agitation mechanism; (b) ingesting the capsule, by the subject; and (c) controlling the vibrating agitation mechanism such that at least a portion of the vibrating mode of operation occurs within the stomach and/or the small intestine of the subject.
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitator, powered by the battery, the vibrating agitator adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitator; and (d) a controller adapted, in response to receipt of an activation input, to activate the vibrating agitator to operate in the first vibrating mode of operation at at least one predetermined time of day. The system and method may be used to treat an ailment of the gastrointestinal tract and/or to mitigate at least one symptom of jetlag in a subject travelling from an origin location to a destination location.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
7.
GASTROINTESTINAL TREATMENT SYSTEM INCLUDING A VIBRATING CAPSULE AND METHOD OF USE THEREOF
A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitator, powered by the battery, the vibrating agitator adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitator; and (d) a controller adapted, in response to receipt of an activation input, to activate the vibrating agitator to operate in the first vibrating mode of operation at at least one predetermined time of day. The system and method may be used to treat an ailment of the gastrointestinal tract and/or to mitigate at least one symptom of jetlag in a subject travelling from an origin location to a destination location.
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
medical devices, namely, a capsule containing a mechanical stimulation mechanism for the relief of constipation and other disorders in the digestive tract of human beings
9.
Methods and systems for treating gastrointestinal disorders
A method for treating a human subject suffering from a gastrointestinal disorder using a non-dissolvable ingestible capsule, the method including providing the non-dissolvable ingestible capsule to the subject, and subsequently, ingesting the non-dissolvable ingestible capsule by the subject, wherein passage of the non-dissolvable ingestible capsule through the gastrointestinal tract of the subject treats the gastrointestinal disorder, and wherein the non-dissolvable ingestible capsule may be at least one of: a non-vibrating capsule, a capsule that is devoid of any electronic components, and a capsule that is devoid of any mechanical moving components.
Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitation mechanism disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.
medical devices, namely, a capsule containing a mechanical stimulation mechanism for the relief of constipation and other disorders in the digestive tract of human beings
An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC. Such agitation means includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
14.
Gastrointestinal treatment system including a vibrating capsule, and method of use thereof
A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitator, powered by the battery, the vibrating agitator adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitator; and (d) a controller adapted, in response to receipt of an activation input, to activate the vibrating agitator to operate in the first vibrating mode of operation at at least one predetermined time of day. The system and method may be used to treat an ailment of the gastrointestinal tract and/or to mitigate at least one symptom of jetlag in a subject travelling from an origin location to a destination location.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
15.
Device and method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user
A device and a method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user. The device includes a vibrating ingestible capsule attached to a medicament delivery compartment. The medicament delivery compartment includes a housing including a portal, a medicament reservoir, a reservoir biasing mechanism applying pressure to the reservoir, a resilient conduit extending from the reservoir to the portal, and a valve including a weight and a spring adapted, when closed, to bias the weight against the conduit so as to block flow therethrough, and, when open, to remove the weight from the conduit to allow fluid to flow through the conduit. When the vibrating agitator is in the vibration mode of operation, vibrations exerted thereby are applied to the valve biasing mechanism and periodically transition the valve between the closed operative orientation and the open operative orientation.
A vibrating ingestible capsule includes a housing, and having a vibrating agitator adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule. A temperature sensor produces temperature information signals. A control element receives a series of temperature information signals from the temperature sensor, compares a measured temperature-over-time pattern, which is based on the series of temperature information signals, to a predetermined temperature-over-time pattern, and, after the measured temperature-over-time corresponds to the predetermined temperature-over-time pattern, activates the vibrating agitator to operate in the first vibrating mode of operation. The predetermined temperature-over-time pattern includes a temperature transition from a first temperature to a second temperature within human body temperature range, which may exceeds the first temperature by a temperature differential of at least 3° C. A rate of the temperature transition may be at least 4° C. per hour.
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
17.
Methods and systems for adaptive treatment of disorders in the gastrointestinal tract
A system and a method for treatment of a disorder in a gastrointestinal tract of a subject, using a treatment protocol, the treatment protocol being based at least in part on data relating to other subjects and their responses to treatment with various treatment protocols.
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
A47L 17/00 - Apparatus or implements used in manual washing or cleaning of crockery, table-ware, cooking-ware or the like
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
E03D 9/00 - Sanitary or other accessories for lavatories
18.
METHOD FOR TREATING CONDITIONS OF THE GI TRACT USING A VIBRATING INGESTIBLE CAPSULE
A method for treating conditions of the gastrointestinal tract of a subject using a vibrating ingestible capsule ingested by the subject and activated in a targeted zone of the gastrointestinal tract of the subject. The conditions may include a sensation of gastric bloating, a sensation of straining during defecating, diarrhea and/or gastroparesis. The method is further suitable for reducing Bristol stool scores of fecal matter of the subject and for increasing a Bristol stool score of fecal matter of the subject.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
A vibration motor, including a shell defining a cavity therein, an axis disposed entirely within the cavity, a first magnet which is rotationally movable relative to the shell and which includes at least two sections having alternating poles, and a second magnet including at least two sections having alternating poles. A first extension tab is attached to the first magnet and extends out of the shell via a slot. An unbalanced rotor is disposed between the first and the second magnets and is rotatable relative to the axis. The first extension tab is movable within the slot, such that moving the tab causes movement of the first magnet and changes a rotational position of the first magnet relative to the second magnet, thereby to change the efficiency of operation of the motor.
H02K 7/06 - Means for converting reciprocating motion into rotary motion or vice versa
H02K 1/34 - Reciprocating, oscillating or vibrating parts of the magnetic circuit
B06B 1/04 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with electromagnetism
20.
Method for treating gastroparesis using a vibrating ingestible capsule
A method for treating gastroparesis in a subject using a vibrating ingestible capsule ingested by the subject and activated in a targeted zone of the gastrointestinal tract of the subject.
A system and a method of using a vibrating gastrointestinal capsule in coordination with an ingestible medicament. The vibrating gastrointestinal capsule may include a housing; a vibrating agitation mechanism causing said housing to exert vibrations on an environment surrounding the vibrating gastrointestinal capsule; a power supply for powering said vibrating agitation mechanism; and a control mechanism for activating said vibrating agitation mechanism to operate in said vibration mode of operation, such that the vibration mode of operation at least partially transpires or completely transpires within an actual or estimated absorption time period of the ingestible medicament within the gastrointestinal tract of the subject.
A method for treating diarrhea in a subject and/or for reducing Bristol stool scores of fecal matter of a subject using a vibrating ingestible capsule ingested by the subject and activated in a targeted zone of the gastrointestinal tract of the subject.
A gastrointestinal capsule and treatment methods utilizing such a capsule, the capsule including: (a) a capsule housing having a longitudinal axis; (b) at least one thrusting mechanism, disposed within the housing, the thrusting mechanism adapted to exert forces on the housing such that, when the capsule is disposed within a gastrointestinal tract of a user, and the mechanism is in an active mode, the gastrointestinal capsule exerts forces against, or in a direction of, the walls of the tract; and (c) a power supply adapted to power the mechanism. The gastrointestinal capsule is used in a method for treating a sensation of straining during defecating and/or for increasing a Bristol stool score of fecal matter of a subject by the gastrointestinal capsule being ingested by the subject and activated in a targeted zone of the gastrointestinal tract of the subject.
A vibrating ingestible capsule includes a housing having a longitudinal axis, and having a vibrating agitation mechanism adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule. A power supply disposed within the housing is adapted to power the vibrating agitation mechanism. A temperature sensor provides temperature information signals with respect to a temperature in an environment surrounding the vibrating ingestible capsule over a period of time. A control element is adapted to receive the temperature information signals from the temperature sensor, to identify a current temperature-overtime pattern based on the temperature information signals received from said temperature sensor, to compare the current temperature-over-time pattern to a predetermined temperature-over-time pattern, and, after the current temperature-overtime matches the predetermined temperature-over-time pattern, to activate the vibrating agitation mechanism to operate in the first vibrating mode of operation.
A vibrating ingestible capsule includes a housing having a longitudinal axis, and having a vibrating agitator adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule. A power supply disposed within the housing is adapted to power the vibrating agitator. A temperature sensor provides temperature information signals with respect to a temperature in an environment surrounding the vibrating ingestible capsule over a period of time. A control element is adapted to receive the temperature information signals from the temperature sensor, to identify a current temperature-over-time pattern based on the temperature information signals received from said temperature sensor, to compare the current temperature-over-time pattern to a predetermined temperature-over-time pattern, and, after the current temperature-over-time matches the predetermined temperature-over-time pattern, to activate the vibrating agitator to operate in the first vibrating mode of operation.
A61H 21/00 - Massage devices for cavities of the body
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
26.
DEVICE AND METHOD FOR DELIVERING A FLOWABLE INGESTIBLE MEDICAMENT INTO THE GASTROINTESTINAL TRACT OF A USER
A device and a method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user. The device includes a vibrating ingestible capsule attached to, or including, a medicament delivery compartment. The medicament delivery compartment includes a housing including a portal, a medicament reservoir, a reservoir biasing mechanism applying pressure to the reservoir, a conduit extending from the reservoir to the portal, and a valve including a weight and a spring adapted, when closed, to bias the weight against the conduit so as to block flow therethrough, and, when open, to remove the weight from the conduit to allow fluid to flow through the conduit. When the vibrating agitation mechanism is in the vibration mode of operation, vibrations exerted thereby are applied to the valve biasing mechanism and periodically transition the valve between the closed operative orientation and the open operative orientation.
A device and a method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user. The device includes a vibrating ingestible capsule attached to a medicament delivery compartment. The medicament delivery compartment includes a housing including a portal, a medicament reservoir, a reservoir biasing mechanism applying pressure to the reservoir, a resilient conduit extending from the reservoir to the portal, and a valve including a weight and a spring adapted, when closed, to bias the weight against the conduit so as to block flow therethrough, and, when open, to remove the weight from the conduit to allow fluid to flow through the conduit. When the vibrating agitator is in the vibration mode of operation, vibrations exerted thereby are applied to the valve biasing mechanism and periodically transition the valve between the closed operative orientation and the open operative orientation.
Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitator disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.
Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitation mechanism disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.
A system and a method of using a vibrating gastrointestinal capsule in coordination with an ingestible medicament. The vibrating gastrointestinal capsule may include a housing; a vibrating agitation mechanism causing said housing to exert vibrations on an environment surrounding the vibrating gastrointestinal capsule; a power supply for powering said vibrating agitation mechanism; and a control mechanism for activating said vibrating agitation mechanism to operate in said vibration mode of operation, such that the vibration mode of operation at least partially transpires or completely transpires within an actual or estimated absorption time period of the ingestible medicament within the gastrointestinal tract of the subject.
A61H 23/00 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61H 21/00 - Massage devices for cavities of the body
31.
Method of enhancing absorption of ingested medicaments for treatment of parkinsonism
A method of using a vibrating gastrointestinal capsule in coordination with an ingestible medicament for treatment of Parkinsonism. The vibrating gastrointestinal capsule, is provided to the subject, and includes: a housing; a vibrating agitation mechanism causing said housing to exert vibrations on an environment surrounding the vibrating gastrointestinal capsule; a power supply for powering said vibrating agitation mechanism; and a control mechanism for activating said vibrating agitation mechanism to operate in said vibration mode of operation. The subject ingests the ingestible medicament and the vibrating gastrointestinal capsule. At least one of a time of ingesting of the vibrating gastrointestinal capsule and a timing or activation delay of the vibration mode of operation is controlled, such that the vibration mode of operation at least partially transpires or completely transpires within an actual or estimated absorption time period of the ingestible medicament within the gastrointestinal tract of the subject.
A method of using a vibrating gastrointestinal capsule in coordination with an ingestible medicament for treatment of an ailment of the GI tract. The vibrating gastrointestinal capsule, is provided to the subject, and includes: a housing; a vibrating agitation mechanism causing the housing to exert vibrations on an environment thereof; a power supply for powering said vibrating agitation mechanism; and a control mechanism for activating said vibrating agitation mechanism to operate in said vibration mode of operation. The subject ingests the ingestible medicament and the vibrating gastrointestinal capsule. At least one of a time of ingesting of the vibrating gastrointestinal capsule and a timing or activation delay of the vibration mode of operation is controlled, such that the vibration mode of operation at least partially transpires or completely transpires within an actual or estimated absorption time period of the ingestible medicament within the gastrointestinal tract of the subject.
A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitation mechanism, powered by the battery, the vibrating agitation mechanism adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitation mechanism; and (d) a control mechanism adapted, in response to receipt of an activation input, to activate the vibrating agitation mechanism to operate in the first vibrating mode of operation at at least one predetermined time of day. The system and method may be used to treat an ailment of the gastrointestinal tract and/or to mitigate at least one symptom of jetlag in a subject travelling from an origin location to a destination location.
A61H 23/00 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms
A61H 21/00 - Massage devices for cavities of the body
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
34.
Methods and systems for adaptive treatment of disorders in the gastrointestinal tract
A system and a method for treatment of a disorder in a gastrointestinal tract of a subject, using a treatment protocol, the treatment protocol being based at least in part on data relating to other subjects and their responses to treatment with various treatment protocols.
A47L 17/00 - Apparatus or implements used in manual washing or cleaning of crockery, table-ware, cooking-ware or the like
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
E03D 9/00 - Sanitary or other accessories for lavatories
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
A system and a method for treatment of a disorder in a gastrointestinal tract of a subject, using a treatment protocol, the treatment protocol being based at least in part on data relating to other subjects and their responses to treatment with various treatment protocols.
A61H 21/00 - Massage devices for cavities of the body
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by an agitation mechanism embedded in the GIC. Such agitation mechanism includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC. Such agitation means includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.
A61H 23/00 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
A gastrointestinal capsule (GIC) including a capsule housing having a longitudinal axis; a thrusting mechanism, disposed within the housing; and a battery adapted to power the and a battery adapted to power the thrusting mechanism; the thrusting mechanism having an active mode, and a passive mode with respect to the active mode, the thrusting mechanism adapted to exert a radial force on the housing, in a radial direction with respect to the axis, such that when the capsule is disposed within a gastrointestinal tract of a user, and the mechanism is in the active mode, the gastrointestinal capsule stimulates a wall of the tract; the active mode including a series of at least two pulses of the radial force, the series having a first duration, the passive mode having a second duration, wherein an activation cycle is defined by the series of pulses followed by the second duration.
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61H 21/00 - Massage devices for cavities of the body
According to the teachings of the present invention there is provided a gastrointestinal capsule and treatment methods utilizing such a capsule, the capsule including: (a) a capsule housing having a longitudinal axis; (b) at least one thrusting mechanism, disposed within the housing, the thrusting mechanism adapted to exert radial forces on the housing, in a radial direction with respect to the axis, such that, when the capsule is disposed within a gastrointestinal tract of a user, and the mechanism is in an active mode, the gastrointestinal capsule exerts forces against, or in a direction of, the walls of the tract; and (c) a power supply adapted to power the mechanism, wherein a ratio of the radial forces to axial forces exerted in an axial direction with respect to the axis, on the housing, by the thrusting mechanism, is at least 1:1.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61H 21/00 - Massage devices for cavities of the body
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC. Such agitation means includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.
A61H 1/00 - Apparatus for passive exercisingVibrating apparatusChiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (Gl) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the Gl wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC. Such agitation means includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.
A61H 1/00 - Apparatus for passive exercisingVibrating apparatusChiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
43.
DEVICE AND METHOD FOR DELIVERING A FLOWABLE INGESTIBLE MEDICAMENT INTO THE GASTROINTESTINAL TRACT OF A USER
A device and a method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user. The device includes a vibrating ingestible capsule attached to, or including, a medicament delivery compartment. The medicament delivery compartment includes a housing including a portal, a medicament reservoir, a reservoir biasing mechanism applying pressure to the reservoir, a conduit extending from the reservoir to the portal, and a valve including a weight and a spring adapted, when closed, to bias the weight against the conduit so as to block flow therethrough, and, when open, to remove the weight from the conduit to allow fluid to flow through the conduit. When the vibrating agitation mechanism is in the vibration mode of operation, vibrations exerted thereby are applied to the valve biasing mechanism and periodically transition the valve between the closed operative orientation and the open operative orientation.
According to the teachings of the present invention there is provided a gastrointestinal capsule and treatment methods utilizing such a capsule, the capsule including: (a) a capsule housing having a longitudinal axis; (b) at least one thrusting mechanism, disposed within the housing, the thrusting mechanism adapted to exert radial forces on the housing, in a radial direction with respect to the axis, such that, when the capsule is disposed within a gastrointestinal tract of a user, and the mechanism is in an active mode, the gastrointestinal capsule exerts forces against, or in a direction of, the walls of the tract; and (c) a power supply adapted to power the mechanism, wherein a ratio of the radial forces to axial forces exerted in an axial direction with respect to the axis, on the housing, by the thrusting mechanism, is at least 1:1.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61H 21/00 - Massage devices for cavities of the body
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
45.
METHODS AND SYSTEMS FOR ADAPTIVE TREATMENT OF DISORDERS IN THE GASTROINTESTINAL TRACT
A system and a method for treatment of a disorder in a gastrointestinal tract of a subject, using a treatment protocol, the treatment protocol being based at least in part on data relating to other subjects and their responses to treatment with various treatment protocols.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61H 21/00 - Massage devices for cavities of the body
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
46.
GASTROINTESTINAL TREATMENT SYSTEM INCLUDING A VIBRATING CAPSULE, AND METHOD OF USE THEREOF
A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitation mechanism, powered by the battery, the vibrating agitation mechanism adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitation mechanism; and (d) a control mechanism adapted, in response to receipt of an activation input, to activate the vibrating agitation mechanism to operate in the first vibrating mode of operation at at least one predetermined time of day. The system and method may be used to treat an ailment of the gastrointestinal tract and/or to mitigate at least one symptom of jetlag in a subject travelling from an origin location to a destination location.
A61H 21/00 - Massage devices for cavities of the body
A61H 23/00 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
47.
VIBRATING CAPSULE FOR ENHANCING ABSORPTION OF INGESTED MEDICAMENTS
A system and a method of using a vibrating gastrointestinal capsule in coordination with an ingestible medicament. The vibrating gastrointestinal capsule may include a housing; a vibrating agitation mechanism causing said housing to exert vibrations on an environment surrounding the vibrating gastrointestinal capsule; a power supply for powering said vibrating agitation mechanism; and a control mechanism for activating said vibrating agitation mechanism to operate in said vibration mode of operation, such that the vibration mode of operation at least partially transpires or completely transpires within an actual or estimated absorption time period of the ingestible medicament within the gastrointestinal tract of the subject.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61H 21/00 - Massage devices for cavities of the body
A61H 23/00 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
48.
DEVICE AND METHOD FOR DELIVERING AN INGESTIBLE MEDICAMENT INTO THE GASTROINTESTINAL TRACT OF A USER
Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitation mechanism disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.
A vibrating ingestible capsule includes a housing having a longitudinal axis, and having a vibrating agitation mechanism adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule. A power supply disposed within the housing is adapted to power the vibrating agitation mechanism. A temperature sensor provides temperature information signals with respect to a temperature in an environment surrounding the vibrating ingestible capsule over a period of time. A control element is adapted to receive the temperature information signals from the temperature sensor, to identify a current temperature-overtime pattern based on the temperature information signals received from said temperature sensor, to compare the current temperature-over-time pattern to a predetermined temperature-over-time pattern, and, after the current temperature-overtime matches the predetermined temperature-over-time pattern, to activate the vibrating agitation mechanism to operate in the first vibrating mode of operation.
An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (Gl) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the Gl wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC. Such agitation means includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.
