Provided herein are methods for decreasing dysbiosis, restoring the microbiome, and/or increasing recovery of a healthy microbiome (e.g. following a dysbiosis inducing event), by administering pharmaceutical compositions to a subject. Also provided are methods for protecting the microbiome of a subject and/or colonizing the microbiome of a subject by administering pharmaceutical compositions to the subject.
Provided herein are methods and compositions for decreasing dysbiosis, restoring the microbiome, and/or increasing recovery of a healthy microbiome (e.g., following a dysbiosis inducing event), by administering compositions to a subject. Also provided are methods for protecting the microbiome of a subject and/or colonizing the microbiome of a subject by administering compositions to the subject.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals and therapeutics for the treatment and prevention of diseases and medical conditions; Pharmaceutical and biopharmaceutical agents, namely, microbiologics, immunotherapeutics, live biotherapeutic products and other therapeutic agents for the treatment and prevention of diseases and medical conditions; Pharmaceuticals in the nature of cultures of microorganisms for medical use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals and therapeutics for the treatment and prevention of diseases and medical conditions; Pharmaceutical and biopharmaceutical agents, namely, microbiologics, immunotherapeutics, live biotherapeutic products and other therapeutic agents for the treatment and prevention of diseases and medical conditions; Pharmaceuticals in the nature of cultures of microorganisms for medical use
5.
COMPOSITIONS AND METHODS FOR SUPPRESSING PATHOGENIC ORGANISMS
Provided herein are compositions and methods for the suppression of multi-drug resistant organisms. Provided herein are compositions and methods for treating diseases or disorders associated with bacterial colonization or treating diseases or disorders associated with an immune response induced by bacteria. Also provided herein are compositions and methods for suppressing colonization of the intestine of subject with oral microbiome bacteria.
Provided herein are methods and compositions for treating cancer, such as gastric cancer, in a subject involving administering a composition comprising a purified bacterial mixture.
Clostridium difficilee.ge.g., atherosclerosis and/or stroke), asthma, and/or cancer involving administering to a subject a pharmaceutical composition comprising a purified bacterial mixture.
Provided herein are compositions and methods for suppressing infection by pathogenic organisms. Also provided herein are compositions and methods for reducing or preventing colonization by pathogenic organisms and methods of treating infection by a pathogenic organism. Also provided herein are compositions comprising taurine and methods of using such compositions for suppressing infection by pathogenic organisms, preventing colonization by pathogenic organisms, and methods of treating infection pathogenic organisms.
The disclosure relates to methods for colonizing a microbiome, by administering pharmaceutical compositions comprising a purified bacterial mixture to the subject. Also provided are methods for treating and/or preventing inflammatory bowel disease, methods for reducing the risk of inflammatory bowel disease and/or reducing the occurrence of inflammatory bowel disease in a subject by administering pharmaceutical compositions comprising a purified bacterial mixture to the subject. Also provided are methods for treating and/or preventing graft versus host disease in a subject by administering pharmaceutical compositions comprising a purified bacterial mixture to the subject.
A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
Provided herein are methods and compositions for treating and/or preventing hepatic encephalopathy involving administering to a subject a pharmaceutical composition comprising a purified bacterial mixture.
A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
The disclosure relates to methods for colonizing a microbiome, by administering pharmaceutical compositions comprising a purified bacterial mixture to the subject. Also provided are methods for treating and/or preventing inflammatory bowel disease, methods for reducing the risk of inflammatory bowel disease and/or reducing the occurrence of inflammatory bowel disease in a subject by administering pharmaceutical compositions comprising a purified bacterial mixture to the subject. Also provided are methods for treating and/or preventing graft versus host disease in a subject by administering pharmaceutical compositions comprising a purified bacterial mixture to the subject.
Provided herein are compositions and methods for suppressing pathogenic organisms. Also provided herein are compositions and methods for inducing regulatory T-cells in response to pathogenic organisms and methods of treating a disease or disorder associated with bacterial colonization. Also provided herein are methods of suppressing colonization of the intestine of a subject with oral microbiome bacteria.
The disclosure provides methods and compositions for the preservation of bacteria. Aspects of the present disclosure provide methods of preparing a preserved bacterial composition comprising flash freezing a bacterial composition and lyophilizing the flash frozen bacterial composition to produce a preserved bacterial composition. In some embodiments, the bacterial composition comprises one or more bacterial strains. In some embodiments, the one or more bacterial strains comprise one or more anaerobic bacterial strains. In some embodiments, the anaerobic bacterial strains are strict anaerobic bacteria.
Provided herein are compositions and methods for treating cancer, treating colitis associated with immune checkpoint inhibitor therapy, colonizing the microbiome, and/or restoring the microbiome, by administering compositions or food products to a subject.
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
Provided herein are methods and compositions for treating cancer, such as gastric cancer, in a subject involving administering a composition comprising a purified bacterial mixture.
Provided herein are compositions and methods for suppressing infection by pathogenic organisms. Also provided herein are compositions and methods for reducing or preventing colonization by pathogenic organisms and methods of treating infection by a pathogenic organism. Also provided herein are compositions comprising taurine and methods of using such compositions for suppressing infection by pathogenic organisms, preventing colonization by pathogenic organisms, and methods of treating infection pathogenic organisms.
Provided herein are methods and compositions for treating and/or preventing hepatic encephalopathy involving administering to a subject a pharmaceutical composition comprising a purified bacterial mixture.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
22.
Methods of decreasing dysbiosis and restoring a microbiome
Provided herein are methods for decreasing dysbiosis, restoring the microbiome, and/or increasing recovery of a healthy microbiome (e.g. following a dysbiosis inducing event), by administering pharmaceutical compositions to a subject. Also provided are methods for protecting the microbiome of a subject and/or colonizing the microbiome of a subject by administering pharmaceutical compositions to the subject.
Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.
Provided herein are compositions and methods for treating cancer, treating colitis associated with immune checkpoint inhibitor therapy, colonizing the microbiome, and/or restoring the microbiome, by administering compositions or food products to a subject.
The disclosure provides methods and compositions for the preservation of bacteria. Aspects of the present disclosure provide methods of preparing a preserved bacterial composition comprising flash freezing a bacterial composition and lyophilizing the flash frozen bacterial composition to produce a preserved bacterial composition. In some embodiments, the bacterial composition comprises one or more bacterial strains. In some embodiments, the one or more bacterial strains comprise one or more anaerobic bacterial strains. In some embodiments, the anaerobic bacterial strains are strict anaerobic bacteria.
The disclosure provides methods and compositions for the preservation of bacteria. Aspects of the present disclosure provide methods of preparing a preserved bacterial composition comprising flash freezing a bacterial composition and lyophilizing the flash frozen bacterial composition to produce a preserved bacterial composition. In some embodiments, the bacterial composition comprises one or more bacterial strains. In some embodiments, the one or more bacterial strains comprise one or more anaerobic bacterial strains. In some embodiments, the anaerobic bacterial strains are strict anaerobic bacteria.
Provided herein are compositions and methods for suppressing pathogenic organisms. Also provided herein are compositions and methods for inducing regulatory T-cells in response to pathogenic organisms and methods of treating a disease or disorder associated with bacterial colonization. Also provided herein are methods of suppressing colonization of the intestine of a subject with oral microbiome bacteria.
Provided herein are compositions and methods for the suppression of multi-drug resistant organisms. Provided herein are compositions and methods for treating diseases or disorders associated with bacterial colonization or treating diseases or disorders associated with an immune response induced by bacteria. Also provided herein are compositions and methods for suppressing colonization of the intestine of subject with oral microbiome bacteria.
Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.
Provided herein are methods for decreasing dysbiosis, restoring the microbiome, and/or increasing recovery of a healthy microbiome ( e.g. following a dysbiosis inducing event), by administering pharmaceutical compositions to a subject. Also provided are methods for protecting the microbiome of a subject and/or colonizing the microbiome of a subject by administering pharmaceutical compositions to the subject.
The disclosure provides compositions comprising a disaccharide, a nutrient, and a buffer, which may be used for the preservation of bacteria, such as during lyophilization and/or extended storage. Provided herein are methods for preserving bacteria, involving adding bacteria to the compositions and subjecting the compositions to a lyophilization cycle. Also provided herein are methods for generating compositions that may be used, for example for the preservation of bacteria.
Provided herein are compositions, methods, and kits for the treatment of cancer. The disclosure also provides compositions, methods, and kits that suppress adverse events caused by anticancer therapy.
Provided herein are compositions and methods for the suppression of multi-drug resistant organisms. Provided herein are compositions and methods for treating diseases or disorders associated with bacterial colonization or treating diseases or disorders associated with an immune response induced by bacteria. Also provided herein are compositions and methods for suppressing colonization of the intestine of subject with oral microbiome bacteria.
Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.
Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.
Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and biopharmaceutical agents, namely,
microbiologics, immunotherapeutics, and other therapeutic
agents, for the prevention and treatment of human diseases,
namely, infectious disease, autoimmune disease, inflammatory
disease, immune disorders, allergic disorders, cancer,
immuno-oncology, metabolic disorders, digestive disorders,
neurological disorders, and cardiovascular disorders;
pharmaceuticals in the nature of cultures of microorganisms
for medical and veterinary use; pharmaceuticals used to
maintain health or restore health to a human or animal
subject via treatment of a disturbed microbial community;
biological preparations in the nature of cultures of
microorganisms for medical purposes; cultures and
preparations of microorganisms for medical and veterinary
purposes; diagnostic agents for medical purposes for
assessing whether a human or animal subject has a disturbed
microbial community; therapeutic agents in the nature of
microorganisms for medical use; nutritional food additives
for medical purposes in the nature of microorganisms;
dietary supplements; beverages for medical purposes;
nutritional food bars for meal replacement and medical
purposes. Research and development of microbiologics,
immunotherapeutics, and other therapeutic agents;
development of pharmaceuticals, diagnostics, food additives,
dietary supplements, medical foods, foods for special
dietary use; scientific research and development services
relating to foods and dietary supplements; providing reagent
sample testing and diagnostic services for others in the
fields of science and research related thereto.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
The disclosure provides methods and compositions for the preservation of bacteria. In particular, provided is a composition comprising a lyoprotectant, a nutrient, an antioxidant, sodium metabisulfite, and a buffer, wherein the buffer is at a pH of 6.7 to 7.3, wherein the lyoprotectant is a disaccharide, but not lactose. Also provided is a method for preserving bacteria comprising (i) adding bacteria to a composition of the disclosure; and (ii) subjecting the composition comprising the bacteria to a lyophilization cycle.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and biopharmaceutical agents, namely,
microbiologics, immunotherapeutics, and other therapeutic
agents, for the prevention and treatment of human diseases;
pharmaceuticals in the nature of cultures of microorganisms
for medical and veterinary use; pharmaceuticals used to
maintain health or restore health to a human or animal
subject via treatment of a disturbed microbial community;
biological preparations in the nature of cultures of
microorganisms for medical purposes; cultures and
preparations of microorganisms for medical and veterinary
purposes; diagnostic agents for medical purposes for
assessing whether a human or animal subject has a disturbed
microbial community; therapeutic agents in the nature of
microorganisms for medical use; nutritional food additives
for medical purposes in the nature of microorganisms;
dietary supplements; beverages for medical purposes;
nutritional food bars for meal replacement and medical
purposes. Research and development of microbiologics,
immunotherapeutics, and other therapeutic agents;
development of pharmaceuticals, diagnostics, food additives,
dietary supplements, medical foods, foods for special
dietary use; scientific research and development services
relating to foods and dietary supplements; providing reagent
sample testing and diagnostic services for others in the
fields of science and research related thereto.
51.
Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease
Compositions consisting of bioactive molecules derived from the microbiota of a mammal are provided herein. When administered orally with a colonic delivery system, the compositions are useful for the prophylaxis and treatment of diseases, in particular inflammatory, autoimmune and infectious diseases. The compositions comprise combinations of small molecules and bacterial antigens formulated in colonic delivery systems. Use of the compositions results in any or all of: induction of immune tolerance; strengthening of the gut mucosal barrier integrity; reduction of inflammation; and amelioration of a disease state caused by inflammation, an autoimmune reaction or an infectious agent.
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and biopharmaceutical agents, namely, microbiologics, immunotherapeutics, and other therapeutic agents, for the prevention and treatment of human diseases, namely, infectious disease, autoimmune disease, inflammatory disease, immune disorders, allergic disorders, cancer, immuno-oncology, metabolic disorders, digestive disorders, neurological disorders, and cardiovascular disorders; Pharmaceuticals in the nature of cultures of microorganisms for medical and veterinary use; Pharmaceuticals used to maintain health or restore health to a human or animal subject via treatment of a disturbed microbial community; biological preparations in the nature of cultures of microorganisms for medical purposes; Cultures and preparations of microorganisms for medical and veterinary purposes; diagnostic agents for medical purposes for assessing whether a human or animal subject has a disturbed microbial community; Therapeutic agents in the nature of microorganisms for medical use; nutritional food additives for medical purposes in the nature of microorganisms; dietary supplements; beverages for medical purposes; nutritional food bars for meal replacement and medical purposes Research and development of microbiologics, immunotherapeutics, and other therapeutic agents; Development of pharmaceuticals, diagnostics, food additives, dietary supplements, medical foods, foods for special dietary use; Scientific research and development services relating to foods and dietary supplements; Providing reagent sample testing and diagnostic services for others in the fields of science and research related thereto
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and biopharmaceutical agents, namely, microbiologics, immunotherapeutics, and other therapeutic agents, for the prevention and treatment of human diseases, namely, infectious disease, autoimmune disease, inflammatory disease, immune disorders, allergic disorders, cancer, immuno-oncology, metabolic disorders, digestive disorders, neurological disorders, and cardiovascular disorders; Pharmaceuticals in the nature of cultures of microorganisms for medical and veterinary use; Pharmaceuticals used to maintain health or restore health to a human or animal subject via treatment of a disturbed microbial community; biological preparations in the nature of cultures of microorganisms for medical purposes; Cultures and preparations of microorganisms for medical and veterinary purposes; diagnostic agents for medical purposes for assessing whether a human or animal subject has a disturbed microbial community; Therapeutic agents in the nature of microorganisms for medical use; nutritional food additives for medical purposes in the nature of microorganisms; dietary supplements; beverages for medical purposes; nutritional food bars for meal replacement and medical purposes Research and development of microbiologics, immunotherapeutics, and other therapeutic agents; Development of pharmaceuticals, diagnostics, food additives, dietary supplements, medical foods, foods for special dietary use; Scientific research and development services relating to foods and dietary supplements; Providing reagent sample testing and diagnostic services for others in the fields of science and research related thereto
