Abstract

The present invention relates to an ophthalmological composition, comprising at least one nicotinic acetylcholine receptor (nAChR) modulator, in particular varenicline, mecamylamine and derivatives, and/or at least one substance of the endogenous Kennedy metabolic pathways, as well as salts and derivatives or pharmaceutically acceptable salts of these substances, and choline-containing phospholipids, salts and derivatives of these substances. From these groups, particular preference is given to choline, phosphocholine, CDP-choline (citicoline), phosphatidylcholine (for example lecithin having a phosphatidylcholine content ≥ 80 wt.%, for example soy lecithin), ethanolamine, phosphoethanolamine, CDP-ethanolamine, phosphatidylethanolamine, L-α-glycerylphosphorylcholine, phosphatidylcholine, and phosphatidylethanolamine.

IPC Classes  ?

• A61K 31/13 - Amines, e.g. amantadine
• A61K 31/14 - Quaternary ammonium compounds, e.g. edrophonium, choline
• A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• A61P 27/02 - Ophthalmic agents
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present invention relates to a self-emulsifying oil-in-water microemulsion or nanoemulsion, containing or consisting of at least one surface-active antioxidant, at least one zwitterionic substance, and at least one active substance. The active substance can be effectively emulsified even in the case of low water solubility, and therefore its bioavailability is significantly increased. In many cases, the improved bioavailability means that the active substance concentration can be accordingly reduced and the biocompatibility can be increased as a result. The present invention also relates to an emulsifying composition, by means of which active substances can be effectively emulsified.

IPC Classes  ?

• A61K 9/107 - Emulsions
• A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
• A61K 8/06 - Emulsions
• A61K 8/92 - Oils, fats or waxesDerivatives thereof, e.g. hydrogenation products
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 31/60 - Salicylic acidDerivatives thereof
• A61K 31/616 - Salicylic acidDerivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
• A61K 31/65 - Tetracyclines
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/38 - CelluloseDerivatives thereof
• A61Q 19/00 - Preparations for care of the skin

Abstract

The present invention addresses the problem of indicating active-ingredient classes which can treat virus diseases caused by coronaviruses in a human or animal. Said treatment includes the acute treatment of an already existing virus disease and the prophylaxis of same. The present invention relates to a bromelain protease, bromelain, jacalin-like lectin, extract from the stem and/or the fruit of a pineapple plant, combination preparation, bromelain protease inhibitor, protein/protease mix, and glycated bromelain protein formed by exogenous non-enzymatic glycation, for use in the treatment or prophylaxis of virus infections caused by coronaviruses in a human or animal.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• A61K 36/88 - Liliopsida (monocotyledons)
• A61P 31/14 - Antivirals for RNA viruses
• C12N 9/50 - Proteinases

Abstract

The present invention relates to a self-emulsifying oil-in-water microemulsion or nanoemulsion, containing or consisting of at least one surface-active antioxidant, at least one zwitterionic substance, and at least one active substance. The active substance can be effectively emulsified even in the case of low water solubility, and therefore its bioavailability is significantly increased. In many cases, the improved bioavailability means that the active substance concentration can be accordingly reduced and the biocompatibility can be increased as a result. The present invention also relates to an emulsifying composition, by means of which active substances can be effectively emulsified.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 9/10 - DispersionsEmulsions
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Abstract

The present invention relates to a self-emulsifying oil-in-water microemulsion or nanoemulsion, containing or consisting of at least one surface-active antioxidant, at least one zwitterionic substance, and at least one active substance. The active substance can be effectively emulsified even in the case of low water solubility, and therefore its bioavailability is significantly increased. In many cases, the improved bioavailability means that the active substance concentration can be accordingly reduced and the biocompatibility can be increased as a result. The present invention also relates to an emulsifying composition, by means of which active substances can be effectively emulsified.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/10 - DispersionsEmulsions
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Abstract

The present invention addresses the problem of indicating active-ingredient classes which can treat virus diseases caused by coronaviruses in a human or animal. Said treatment includes the acute treatment of an already existing virus disease and the prophylaxis of same. The present invention relates to a bromelain protease, bromelain, jacalin-like lectin, extract from the stem and/or the fruit of a pineapple plant, combination preparation, bromelain protease inhibitor, protein/protease mix, and glycated bromelain protein formed by exogenous non-enzymatic glycation, for use in the treatment or prophylaxis of virus infections caused by coronaviruses in a human or animal.

IPC Classes  ?

• A61K 36/88 - Liliopsida (monocotyledons)
• A61K 38/46 - Hydrolases (3)
• A61P 31/12 - Antivirals

Abstract

The invention relates to a food supplement containing minerals and/or vitamins, a humectant and, for example, essential oils. The food supplement is formulated as an oral spray. In particular, the invention relates to a concentrated food supplement in the form of an oral spray, containing a combination of magnesium ions, panthenol (vitamin B5), caffeine, menthol aroma and/or peppermint aroma, and a humectant. The food supplement is particularly suited for use in sport and in stressful situations.

IPC Classes  ?

• A61K 33/14 - Alkali metal chloridesAlkaline earth metal chlorides
• A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
• A23L 33/15 - Vitamins
• A23L 33/29 - Mineral substances, e.g. mineral oils or clays
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/08 - Solutions
• A61K 9/107 - Emulsions
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• A61K 47/46 - Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
• A61K 31/355 - Tocopherols, e.g. vitamin E
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61K 31/4415 - Pyridoxine, i.e.vitamin B6
• A61K 31/51 - Thiamines, e.g. vitamin B1
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61K 31/525 - Isoalloxazines, e.g. riboflavins, vitamin B2

Abstract

The invention relates to a food supplement containing minerals and/or vitamins, a humectant and, for example, essential oils. The food supplement is formulated as an oral spray. In particular, the invention relates to a concentrated food supplement in the form of an oral spray, containing a combination of magnesium ions, panthenol (vitamin B5), caffeine, menthol aroma and/or peppermint aroma, and a humectant. The food supplement is particularly suited for use in sport and in stressful situations.

IPC Classes  ?

• A23L 27/12 - Natural spices, flavouring agents or condimentsExtracts thereof from fruit, e.g. essential oils
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A23L 33/15 - Vitamins
• A23L 33/16 - Inorganic salts, minerals or trace elements
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 33/00 - Medicinal preparations containing inorganic active ingredients
• A61K 36/53 - Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• A61K 36/534 - Mentha (mint)
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61Q 90/00 - Cosmetics or similar toiletry preparations for specific uses not provided for in other groups of this subclass

Abstract

The invention relates to a food supplement containing minerals and/or vitamins, a humectant and, for example, essential oils. The food supplement is formulated as an oral spray. In particular, the invention relates to a concentrated food supplement in the form of an oral spray, containing a combination of magnesium ions, panthenol (vitamin B5), caffeine, menthol aroma and/or peppermint aroma, and a humectant. The food supplement is particularly suited for use in sport and in stressful situations.

IPC Classes  ?

• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A61Q 90/00 - Cosmetics or similar toiletry preparations for specific uses not provided for in other groups of this subclass
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 33/00 - Medicinal preparations containing inorganic active ingredients
• A61K 36/53 - Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• A61K 36/534 - Mentha (mint)
• A23L 27/12 - Natural spices, flavouring agents or condimentsExtracts thereof from fruit, e.g. essential oils
• A23L 33/15 - Vitamins
• A23L 33/16 - Inorganic salts, minerals or trace elements

Abstract

The present invention relates to a composition comprising multilamellar vesicles from neutralised hydrogenated polymerised fatty acids. The hydrogenated polymerised fatty acids are obtained from a feedstock comprising C18 unsaturated fatty acids. The multilamellar vesicles are excellent for ocular or nasal care.

IPC Classes  ?

• A61K 31/728 - Hyaluronic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/10 - DispersionsEmulsions
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61P 11/02 - Nasal agents, e.g. decongestants
• A61P 27/04 - Artificial tearsIrrigation solutions

Abstract

The invention relates to a kit for the topical cosmetic treatment of the eye and the skin, and a cosmetic contained therein for application to the eye and to the skin.

IPC Classes  ?

• A61K 8/365 - Hydroxycarboxylic acidsKetocarboxylic acids
• A61Q 1/14 - Preparations for removing make-up
• A61K 8/73 - Polysaccharides
• A61Q 19/00 - Preparations for care of the skin
• A61K 8/368 - Carboxylic acidsSalts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
• A61K 8/34 - Alcohols
• A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
• A61K 31/60 - Salicylic acidDerivatives thereof

Abstract

The invention relates to an ophthalmological composition with high viscosity. The claimed composition contains or consists of hyaluronic acid or a hyaluronic acid derivative such as an ophthalmologically acceptable salt of the hyaluronic acid, and ectoine or an ophthalmologically acceptable ectoine derivative. The composition is also characterised in that it does not contain any other pharmaceutically active ingredient.

IPC Classes  ?

• A61K 9/08 - Solutions
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/728 - Hyaluronic acid

Abstract

The invention relates to an ophthalmological composition with high viscosity. The claimed composition contains or consists of hyaluronic acid or a hyaluronic acid derivative such as an ophthalmologically acceptable salt of the hyaluronic acid, and ectoine or an ophthalmologically acceptable ectoine derivative. The composition is also characterised in that it does not contain any other pharmaceutically active ingredient.

IPC Classes  ?

• A61K 9/08 - Solutions
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/728 - Hyaluronic acid

Abstract

Aronia extract in an amount of at least about 10 μg/mg and seleniumin in an amount from about 0.0001 μg/mg to about 2.0 μg/mg. The composition may further comprise zinc as additional micronutrient. The composition may be formulated as a pharmaceutical or a nutraceutical composition.

IPC Classes  ?

• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61K 9/28 - DrageesCoated pills or tablets
• A61K 9/08 - Solutions
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 33/30 - ZincCompounds thereof
• A61K 36/73 - Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 37/02 - Immunomodulators
• A61P 37/08 - Antiallergic agents

Abstract

The invention relates to an aqueous pharmaceutical composition, which comprises an anti-inflammatory and/or antiallergic agent, oil, and at least one viscosity regulator. The invention further relates to the use of said pharmaceutical composition for preventing and/or treating allergically irritated nasal mucosa.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
• A61K 47/46 - Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
• A61P 11/02 - Nasal agents, e.g. decongestants

Abstract

The invention relates to a metering pump for a metering device for the metered dispensing of a liquid, which metering device can be connected to a supply container, the metering pump comprising a cylindrical pump body and an actuating body.

IPC Classes  ?

• B05B 11/00 - Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use

Abstract

The present invention pertains to a composition which comprises a combination of Aronia extract in an amount of at least about 10 .mu.g/mg and seleniumin in an amount from about 0,0001 .mu.g/mg to about 2.0 .mu.g/mg. The composition may further comprise zinc as additional micronutrient. The composition may be formulated as a pharmaceutical or a nutraceutical composi-tion.

IPC Classes  ?

• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61K 33/30 - ZincCompounds thereof
• A61K 36/73 - Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

The invention relates to a phosphate-free pharmaceutical composition which comprises at least one FP prostanoid receptor agonist and/or at least one prostamide receptor agonist and citrate salts and/or citric acid.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/08 - Solutions
• A61P 27/06 - Antiglaucoma agents or miotics

Abstract

The present invention pertains to a composition which comprises a combination of Aronia extract in an amount of at least about 10 μg/mg and seleniumin in an amount from about 0,0001 μg/mg to about 2.0 μg/mg. The composition may further comprise zinc as additional micronutrient. The composition may be formulated as a pharmaceutical or a nutraceutical composition.

IPC Classes  ?

• A61K 36/73 - Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61K 33/30 - ZincCompounds thereof
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

The present invention pertains in general to Bromelain and particularly to the active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed Bromelain inhibitor precursor and Bromelain inhibitors, which are found in Bromelain. It has been found that the recombinant expressed inhibitors have superior effects in terms of treatment of disorders and conditions than Bromelain or its protein fractions from plant extracts.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61P 35/00 - Antineoplastic agents
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 31/04 - Antibacterial agents
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors

Abstract

The present invention pertains in general to Bromelain and particularly to the different active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed cysteine proteases, which are found in Bromelain. It has been found that the method for expression of the recombinant proteins is superior to the purification from Bromelain itself.

IPC Classes  ?

• C12N 9/50 - Proteinases
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C12N 15/29 - Genes encoding plant proteins, e.g. thaumatin
• C12N 15/57 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A23J 3/34 - Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
• A61Q 19/00 - Preparations for care of the skin