C07D 473/16 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
C07D 473/18 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
In a preferred embodiment, there is provided a compound having structural Formula I, II, III or IV.
In a preferred embodiment, there is provided a compound having structural Formula I, II, III or IV.
In a preferred embodiment, there is provided a method for preparing a crown ether, the method comprising: loading a resin having a resin functional group with a linking compound having a functional group selected for coupling to the resin functional group and at least two carbon atoms each having a substituent; coupling the linking compound to a polyethylene glycol having two terminal carbon atoms each bonded to an optionally protected terminal hydroxyl group to obtain a cyclized intermediate, whereby one said at least two carbon atoms or the substituent and an associated one of the two terminal carbon atoms or the hydroxyl groups undergo a coupling or substitution reaction; and removing the linking compound and the cyclized intermediate from the resin.
A01N 57/34 - Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-halogen bondsPhosphonium salts
In a preferred embodiment, there is provided a method for determining a breathing pattern, the method comprising: placing a motion sensor and a flex sensor proximate to a diaphragm of a subject; obtaining time domain signals or data from both said sensors over a time period; subjecting the time domain signals or data from the motion sensor to Fast Fourier transformation to obtain frequency domain signals or data, and determining from the frequency domain signals or data one or more frequencies associated with body motion of the subject substantially unrelated to breathing; and filtering the time domain signals or data from the flex sensor to remove information related to the body motion therefrom to obtain filtered time domain signals or data.
In a preferred embodiment, there is provided a pharmaceutical coordination composition having a plurality of central atoms or ions, a multitopic ligand and one or more pharmaceutical compounds coordinated to at least one of the plurality of the central atoms or ions, wherein the multitopic ligand is coordinated to at least two of the plurality of central atoms or ions.
A61K 47/52 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
7.
Debossed Contact Printing as a Patterning Method for Paper-Based Electronics
In a preferred embodiment, there is provided a method for preparing a printed electronic device, the method comprising debossing a recessed relief or relief pattern into a plane of a substrate, and applying an electrically functional ink generally along the plane, thereby depositing the ink on the substrate substantially without depositing the ink on the recessed relief or relief pattern.
H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material
H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances
A resonator and/or transducer comprising at least one deflectable membrane, a fixed substrate, and at least one cavity defined between the at least one deflectable membrane and the fixed substrate. A Free to Fixed Boundary Ratio (FFBR) of the deflectable membrane is selected to optimize a characteristic of the resonator and/or transducer, such as resonant frequency, displacement, operating voltage, electromechanical coupling coefficient, or mass sensitivity.
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
B06B 1/02 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy
9.
ALTERING AND ENHANCING RESONATOR PERFORMANCES USING FREE TO FIXED BOUNDARY RATIO (FFBR) TOPOLOGY
A resonator and/or transducer comprising at least one deflectable membrane, a fixed substrate, and at least one cavity defined between the at least one deflectable membrane and the fixed substrate. A Free to Fixed Boundary Ratio (FFBR) of the deflectable membrane is selected to optimize a characteristic of the resonator and/or transducer, such as resonant frequency, displacement, operating voltage, electromechanical coupling coefficient, or mass sensitivity.
In a preferred embodiment, there is provided a method for measuring a capacitance change or difference of a sensing capacitor, the method comprising: sweeping a frequency range of first and second alternating current (AC) voltage sources respectively connected to first and second amplifiers, said first amplifier having or connected to a first reference capacitor or electrode and said second amplifier having or connected to a second reference capacitor or electrode and the sensing capacitor; detecting first and second high cutoff frequencies respectively of the first and second amplifiers; and determining a difference between the first and second high cutoff frequencies, wherein the difference reflects the capacitance change or difference.
G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
G01D 5/24 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance
11.
NOVEL CAPACITANCE VARIATION MEASUREMENT MIXED SIGNAL IC BASED ON HIGH-FREQUENCY RESPONSE
. .In a preferred embodiment, there is provided a method for measuring a capacitance change or difference of a sensing capacitor, the method comprising: sweeping a frequency range of first and second alternating current (AC) voltage sources respectively connected to first and second amplifiers, said first amplifier having or connected to a first reference capacitor or electrode and said second amplifier having or connected to a second reference capacitor or electrode and the sensing capacitor; detecting first and second high cutoff frequencies respectively of the first and second amplifiers; and determining a difference between the first and second high cutoff frequencies, wherein the difference reflects the capacitance change or difference.CA 3199358 2023-05-10
G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
G01R 17/02 - Arrangements in which the value to be measured is automatically compared with a reference value
G01R 27/26 - Measuring inductance or capacitanceMeasuring quality factor, e.g. by using the resonance methodMeasuring loss factorMeasuring dielectric constants
12.
QCM WITH ELECTRODE CONFIGURATION BASED ON DISTRIBUTION OF AREA FOR IMPROVING MASS SNSITIVITY (DAIS)
In a preferred embodiment, there is provided a quartz crystal microbalance comprising a pair of electrodes and a quartz crystal disposed therebetween, one said electrode operable as a sensing electrode for interacting with an analyte, wherein said sensing electrode comprises an array of sensing electrode members positioned within a sensing electrode surface portion on the quartz crystal.
13.
QCM WITH ELECTRODE CONFIGURATION BASED ON DISTRIBUTION OF AREA FOR IMPROVING MASS SENSITIVITY (DAIS)
In a preferred embodiment, there is provided a quartz crystal microbalance comprising a pair of electrodes and a quartz crystal disposed therebetween, one said electrode operable as a sensing electrode for interacting with an analyte, wherein said sensing electrode comprises an array of sensing electrode members positioned within a sensing electrode surface portion on the quartz crystal.
In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
In a preferred embodiment, there is provided a modified fabric composition, the composition comprising a fabric member and an electroactive member for storing energy, wherein the fabric member comprises a fabric framework defining a deformable plane and a plurality of projections extending at an angle from the plane, and wherein the electroactive member is coupled to at least one of the projections.
H01M 4/74 - Meshes or woven materialExpanded metal
D06M 11/51 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with sulfur, selenium, tellurium, polonium or compounds thereof
D04B 1/04 - Pile fabrics or articles having similar surface features characterised by thread material
C23C 18/08 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of metallic material
In a preferred embodiment, there is provided a method for reducing power consumption in an artificial neural network, the method comprising: receiving an input signal; modulating a sampling frequency of an artificial neuron based on the input signal; and forwarding the input signal or a further input signal obtained from the input signal to the artificial neuron at the sampling frequency, wherein said modulating the sampling frequency comprises increasing the sampling frequency with an increased input signal and reducing the sampling frequency with a decreased input signal.
In a preferred embodiment, there is provided a method for reducing power consumption in an artificial neural network, the method comprising: receiving an input signal; modulating a sampling frequency of an artificial neuron based on the input signal; and forwarding the input signal or a further input signal obtained from the input signal to the artificial neuron at the sampling frequency, wherein said modulating the sampling frequency comprises increasing the sampling frequency with an increased input signal and reducing the sampling frequency with a decreased input signal.
In a preferred embodiment, there is provided a pharmaceutical coordination composition having a plurality of central atoms or ions, a multitopic ligand and one or more pharmaceutical compounds coordinated to at least one of the plurality of the central atoms or ions, wherein the multitopic ligand is coordinated to at least two of the plurality of central atoms or ions.
A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/56 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
C07C 237/06 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C07D 233/61 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
19.
THERAPEUTIC COORDINATION POLYMERS CONTAINING PHARMACEUTICALS FOR DRUG RELEASE APPLICATIONS
In a preferred embodiment, there is provided a pharmaceutical coordination composition having a plurality of central atoms or ions, a multitopic ligand and one or more pharmaceutical compounds coordinated to at least one of the plurality of the central atoms or ions, wherein the multitopic ligand is coordinated to at least two of the plurality of central atoms or ions.
A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/56 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
C07C 237/06 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C07D 233/61 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
20.
MEMS VIBRATING RING RESONATOR WITH DEFORMABLE INNER RING-SHAPED SPRING SUPPORTS
A Microelectromechanical systems (MEMS) based ring resonator includes an outer ring which is supported in resilient deformable movement relative to one or more peripherally disposed electrodes by a symmetrically positioned array of radially extending inner spring supports. The inner spring supports extend radially from a central anchor post or support to the inner circumferential edge of the outer ring. The inner spring supports are configured to deformation or regulate movement in outer ring driving and sensing modes.
B81B 3/00 - Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes
G01C 19/5684 - Turn-sensitive devices using vibrating masses, e.g. vibratory angular rate sensors based on Coriolis forces using the phase shift of a vibration node or antinode of essentially two-dimensional vibrators, e.g. ring-shaped vibrators the devices involving a micromechanical structure
21.
Non-destructive evaluation system for inspection of weld and braze joints
An inspection probe and system for inspecting a welded or brazed joint includes a housing having an internal cavity and opposed tapered standoffs disposed at a distal end portion of the housing. Distal ends of the opposed tapered standoffs define pivot surfaces, and the opposed tapered standoffs are spaced apart to define a secondary enclosure. A plurality of transducer elements are disposed within the internal cavity of the housing and a primary coupling medium made of a flexible, semi-solid material is secured between the opposed tapered standoffs. A signal processing module is in communication with a data acquisition unit, which is in communication with the transducer elements. The inspection probe is rotated across the joint, data from the transducer elements is communicated to the signal processing module, and reconstructed and corrected images obtained at different angles from the transducer elements are stitched to generate an inspection image.
G06F 30/12 - Geometric CAD characterised by design entry means specially adapted for CAD, e.g. graphical user interfaces [GUI] specially adapted for CAD
G06T 3/4038 - Image mosaicing, e.g. composing plane images from plane sub-images
A motor drive system for an electrified vehicle includes a DC source, such as a battery, and an inverter, which includes one or more phase drivers, each configured to switch current from the DC source to generate AC power upon one or more output terminals using a hybrid of two or more different solid-state switches, each having a corresponding voltage rating. A nine-switch inverter includes three phase drivers, each including high, low, and middle solid-state switches, with Si-MOSFET high and low switches having a first voltage rating of half of the rated voltage of the system, and with Gallium Nitride (GaN) transistors rated to block a full rated voltage of the system used for the middle switches. A delay driver synchronizes timing between two different solid-state switches by energizing control terminals at different rates. The inverter can be operated using near-state pulse-width modulation (NSPWM) to reduce switching losses.
H02P 27/08 - Arrangements or methods for the control of AC motors characterised by the kind of supply voltage using variable-frequency supply voltage, e.g. inverter or converter supply voltage using DC to AC converters or inverters with pulse width modulation
B60L 15/00 - Methods, circuits or devices for controlling the propulsion of electrically-propelled vehicles, e.g. their traction-motor speed, to achieve a desired performanceAdaptation of control equipment on electrically-propelled vehicles for remote actuation from a stationary place, from alternative parts of the vehicle or from alternative vehicles of the same vehicle train
H02M 1/084 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters using a control circuit common to several phases of a multi-phase system
H02M 7/5387 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration
23.
Thermally sensitive protecting groups for cysteine for peptide cyclization and selective disulfide bond formation
In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
A system and method are provided for growing cyber security awareness relating to social engineering and administering anti-social engineering training. The system makes use of artificial intelligence (AI), cyber security strategies and/or gamification principles to help organizations better understand and prepare for potential social engineering security risks. One embodiment of the system includes a reinforcement learning (RL) module, which further includes a trained predictor and an agent that interacts with a target. The RL module receives as input a training dataset that includes information about the target. The trained predictor generates a bait for the target based on the input training dataset; and the agent delivers the generated bait as an attack on the target. The RL module outputs a playbook of the attack, which can be used to update the training dataset and the trained predictor for subsequent iterative attacks, and/or to recommend social engineering countermeasures to the target.
In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
An analyzer for diagnosing pulmonary and abdominals including, a pulsed force generator for outputting a mechanical disturbance to generate vibrations and reflected/return waves/vibrations in a patient's torso, and sensors for detecting the vibration/return wave signals. The apparatus compares the detected electrical signals with pre-stored reference wave profiles and based on the compared data generates an output signal indicative of a potential presence or absence of a pulmonary disease and/or condition.
A61B 9/00 - Instruments for examination by percussionPleximeters
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
27.
Tufted pile fabric as framework for stretchable and wearable composite electrodes
In a preferred embodiment, there is provided a modified fabric composition, the composition comprising a fabric member and an electroactive member for storing energy, wherein the fabric member comprises a fabric framework defining a deformable plane and a plurality of projections extending at an angle from the plane, and wherein the electroactive member is coupled to at least one of the projections.
H01M 4/74 - Meshes or woven materialExpanded metal
D06M 11/51 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with sulfur, selenium, tellurium, polonium or compounds thereof
D04B 1/04 - Pile fabrics or articles having similar surface features characterised by thread material
C23C 18/08 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of metallic material
28.
TUFTED PILE FABRIC AS FRAMEWORK FOR STRETCHABLE AND WEARABLE COMPOSITE ELECTRODES
ABSTRACTIn a preferred embodiment, there is provided a modified fabric composition, the composition comprising a fabric member and an electroactive member for storing energy, wherein the fabric member comprises a fabric framework defining a deformable plane and a plurality of projections extending at an angle from the plane, and wherein the electroactive member is coupled to at least one of the projections.CA 3101146 2020-11-27
D04B 1/00 - Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machinesFabrics or articles defined by such processes
In a preferred embodiment, there is provided a self-healing polymer composition preferably for use in manufacturing a dielectric layer of a capacitive pressure sensor, and which comprises a central atom and a polymer having a main chain and one or more terminal moieties coupled to the main chain, wherein said one or more terminal moieties are selected to operate as ligands to form a coordination complex with the central atom, and preferably, the ligands and the central atom are selected to form the coordination complex after being subject to an external force sufficient to remove coordinate covalent bonds therebetween.
C08L 83/08 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
C08K 3/11 - Compounds containing metals of Groups 4 to 10 or of Groups 14 to 16 of the Periodic Table
C08G 77/388 - Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing nitrogen
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
C08G 77/26 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen nitrogen-containing groups
In a preferred embodiment, there is provided a self-healing polymer composition preferably for use in manufacturing a dielectric layer of a capacitive pressure sensor, and which comprises a central atom and a polymer having a main chain and one or more terminal moieties coupled to the main chain, wherein said one or more terminal moieties are selected to operate as ligands to form a coordination complex with the central atom, and preferably, the ligands and the central atom are selected to form the coordination complex after being subject to an external force sufficient to remove coordinate covalent bonds therebetween.
In a preferred embodiment, there is provided a protected cysteine having structural formula 9 or 10:wherein X and Y are independently of each other oxygen, sulfur, nitrogen or phosphorus; RI and R2 are independently of each other hydrogen, hydroxyl, halo, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, formyl, haloformyl, carbonyl, carboxyl, alkoxy, alkoxycarbonyl, (alkoxycarbonyl)oxy; carbamoyl, amino, amido, imino, imido, azo, cyanato, isocyanato, cyano, nitro, sulfanyl, thiocyanato or phosphono, each of which is optionally substituted; R3 and R4 are independently of each other hydrogen or a protecting group; and n is an integer between 1 and 12, inclusive.
A motor drive system and method for determining an optimized efficiency of the motor drive system are provided. The motor drive system includes a system controller, a motor drive having includes an inverter configured to generate the AC power upon one or more motor leads, and an electric motor, which is to convert the AC power from the motor leads to rotational energy. A dynamometer may include a load coupled to the shaft and sensors to measure to measure operating characteristics such as torque and speed of the electric motor. The system controller is configured to generate a lookup table, with an entry describing an output current command for operating the inverter and the motor at a maximum system efficiency for a given combination rotational speed and output torque. Motor temperature may also be measured and used as an additional index into the lookup table.
H02P 21/02 - Arrangements or methods for the control of electric machines by vector control, e.g. by control of field orientation specially adapted for optimising the efficiency at low load
H02P 21/22 - Current control, e.g. using a current control loop
H02P 21/14 - Estimation or adaptation of machine parameters, e.g. flux, current or voltage
H02P 21/06 - Rotor flux based control involving the use of rotor position or rotor speed sensors
H02P 6/08 - Arrangements for controlling the speed or torque of a single motor
H02P 21/00 - Arrangements or methods for the control of electric machines by vector control, e.g. by control of field orientation
H02P 27/08 - Arrangements or methods for the control of AC motors characterised by the kind of supply voltage using variable-frequency supply voltage, e.g. inverter or converter supply voltage using DC to AC converters or inverters with pulse width modulation
H02P 27/06 - Arrangements or methods for the control of AC motors characterised by the kind of supply voltage using variable-frequency supply voltage, e.g. inverter or converter supply voltage using DC to AC converters or inverters
H02P 27/04 - Arrangements or methods for the control of AC motors characterised by the kind of supply voltage using variable-frequency supply voltage, e.g. inverter or converter supply voltage
H02P 6/34 - Modelling or simulation for control purposes
B60L 15/20 - Methods, circuits or devices for controlling the propulsion of electrically-propelled vehicles, e.g. their traction-motor speed, to achieve a desired performanceAdaptation of control equipment on electrically-propelled vehicles for remote actuation from a stationary place, from alternative parts of the vehicle or from alternative vehicles of the same vehicle train for control of the vehicle or its driving motor to achieve a desired performance, e.g. speed, torque, programmed variation of speed
33.
MOTOR DRIVE TOPOLOGIES FOR TRACTION AND CHARGING IN ELECTRIFIED VEHICLES
A motor drive system for an electrified vehicle includes a DC source, such as a battery, and an inverter, which includes one or more phase drivers, each configured to switch current from the DC source to generate AC power upon one or more output terminals using a hybrid of two or more different solid-state switches, each having a corresponding voltage rating. A nine-switch inverter includes three phase drivers, each including high, low, and middle solid-state switches, with Si-MOSFET high and low switches having a first voltage rating of half of the rated voltage of the system, and with Gallium Nitride (GaN) transistors rated to block a full rated voltage of the system used for the middle switches. A delay driver synchronizes timing between two different solid-state switches by energizing control terminals at different rates. The inverter can be operated using near-state pulse-width modulation (NSPWM) to reduce switching losses.
H02M 7/48 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
H02M 7/44 - Conversion of DC power input into AC power output without possibility of reversal by static converters
H02M 7/537 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
H02P 27/06 - Arrangements or methods for the control of AC motors characterised by the kind of supply voltage using variable-frequency supply voltage, e.g. inverter or converter supply voltage using DC to AC converters or inverters
B60L 50/51 - Electric propulsion with power supplied within the vehicle using propulsion power supplied by batteries or fuel cells characterised by AC-motors
This invention relates to elastomeric coatings for electronics. Disclosed is a electronic device comprising a substrate layer, a conductive layer and an encapsulant layer. The encapsulant layer comprises at least a butyl rubber material. The butyl rubber encapsulant prevents a change in resistivity of the conductive layer following exposure to nitric acid vapour for 12 hours or hydrochloric acid vapour for 10 hours.
B32B 25/18 - Layered products essentially comprising natural or synthetic rubber comprising butyl or halobutyl rubber
B32B 17/10 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like comprising glass as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
B32B 17/06 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like comprising glass as the main or only constituent of a layer, next to another layer of a specific substance
H01L 23/29 - Encapsulation, e.g. encapsulating layers, coatings characterised by the material
In a preferred embodiment, there is provided a method for preparing a capacitive pressure sensor, the sensor comprising a pair of conductive plate layers and a dielectric layer disposed therebetween, the dielectric layer comprising a dielectric polymer formed with a polymerization mixture fluid, wherein the method comprises placing the polymerization mixture fluid over a mold surface having a first three dimensional pattern thereon to form the dielectric polymer, thereby forming a second three dimensional pattern on a surface of the dielectric polymer complementary to the first three dimensional pattern.
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
G01L 9/12 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elementsTransmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in capacitance
A multilevel power converter, or inverter, for converting a direct current electrical power to an alternating current electrical power includes one or more 2-level converters each including gallium nitride (GaN) transistors configured to switch two input lines to a three-phase output line. The multilevel power converter may be used in a motor drive circuit, which may provide a 3-phase AC supply. Two power converters, which may be 2-level or 3-level power converters, may be alternately switched to provide the AC power to an AC motor by an output stage including bi-directional switching transistors configured to switch a corresponding three-phase output lines from the multilevel power converters. The multilevel power converters switch input lines from a neutral-point clamped input stage including capacitors connected in series across input terminals having a DC voltage therebetween to energize a midpoint terminal with an intermediate voltage half of the voltage between the input terminals.
H02M 7/00 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output
H02M 7/72 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
A multilevel power converter, or inverter, for converting a direct current electrical power to an alternating current electrical power includes one or more 2-level converters each including gallium nitride (GaN) transistors configured to switch two input lines to a three-phase output line. The multilevel power converter may be used in a motor drive circuit, which may provide a 3-phase AC supply. Two power converters, which may be 2-level or 3-level power converters, may be alternately switched to provide the AC power to an AC motor by an output stage including bi-directional switching transistors configured to switch a corresponding three-phase output lines from the multilevel power converters. The multilevel power converters switch input lines from a neutral-point clamped input stage including capacitors connected in series across input terminals having a DC voltage therebetween to energize a midpoint terminal with an intermediate voltage half of the voltage between the input terminals.
H02M 7/00 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output
H02M 7/72 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
38.
ELECTRIC MOTOR DRIVE WITH GALLIUM NITRIDE POWER SWITCHES
A motor drive for providing AC power to an electric motor includes a DC bus and three output terminals for connection to the electric motor. A positive switch selectively connects a positive conductor of the DC bus with each of the output terminals and a negative switch selectively connects a negative conductor of the DC bus with each of the output terminals. Each of the switches are Gallium Nitride (GaN) power switches. A controller commands each of the switches at a high switching speed between 10 kHz and 100 kHz using pulse width modulation to approximate an AC waveform on each of the output terminals. A dead time between activation of corresponding two of the switches conn to be selected to minimize a fifth-order harmonic distortion current.
H02M 1/12 - Arrangements for reducing harmonics from AC input or output
H02M 7/537 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
H02P 27/00 - Arrangements or methods for the control of AC motors characterised by the kind of supply voltage
H02P 27/06 - Arrangements or methods for the control of AC motors characterised by the kind of supply voltage using variable-frequency supply voltage, e.g. inverter or converter supply voltage using DC to AC converters or inverters
39.
MMTV-SV40-Spy1A and Spy1A-pTRE transgenic mouse models
In one aspect, the invention provides a transgenic non-human animal model having germ cells and somatic cells containing an endogenous MMTV-SV40-Spy1A gene sequence introduced into said animal model or an ancestor of said animal model at an embryonic stage, wherein said gene sequence comprises a mouse mammary tumor virus gene (MMTV), a functionally disrupted SV40 gene (SV40) and a human Spy1A gene. In another aspect, the present invention provides a transgenic non-human animal model whose germ cells and somatic cells contain an endogenous Spy1A-pTRE-Tight gene sequence introduced into said animal model or an ancestor of said animal model at an embryonic stage. Preferably, the Spy1A-pTRE-Tight animal model expresses the Spy1A gene and develop cancer, preferably breast cancer, when administered with tetracycline, preferably doxycycline.
An integrated circuit includes stacked benzocyclobutene layers and a circuit geometry comprising conductive electric traces and interconnects on and/or extending through the BCB layers. A first said BCB layer formed and partially cured state. A top surface masked with photoresist, and after exposure, etched selectively form through vias at locations corresponding to conductive interconnects of the circuit geometry associated with said first BCB layer. A further mask coating is applied and after exposure, conductive metal is deposited to infill vias and form the electric traces of the circuit geometry. Subsequent BCB layers are then likewise formed, etched masked and coated in the same manner.
An analyzer for diagnosing pulmonary and abdominals including, a pulsed force generator for outputting a mechanical disturbance to generate vibrations and reflected / return waves/vibrations in a patient's torso, and sensors for detecting the vibration / return wave signals. The apparatus compares the detected electrical signals with pre-stored reference wave profiles and based on the compared data generates an output signal indicative of a potential presence or absence of a pulmonary disease and/or condition.
An analyzer for diagnosing pulmonary and abdominals including, a pulsed force generator for outputting a mechanical disturbance to generate vibrations and reflected / return waves/vibrations in a patient's torso, and sensors for detecting the vibration / return wave signals. The apparatus compares the detected electrical signals with pre-stored reference wave profiles and based on the compared data generates an output signal indicative of a potential presence or absence of a pulmonary disease and/or condition.
A printed target model is formed by 3D printing by inputting target model data, and based on target model data, identifying surface portions requiring support. The surface portions are projected onto a virtual printer table, and one or more virtual support structures having a V-shaped cap portion and optionally a generally planar web are created therefore. The virtual model is then used to control a 3D printer to integrally print-form the target model and support structures.
A printed target model is formed by 3D printing by inputting target model data, and based on target model data, identifying surface portions requiring support. The surface portions are projected onto a virtual printer table, and one or more virtual support structures having a V-shaped cap portion and optionally a generally planar web are created therefore. The virtual model is then used to control a 3D printer to integrally print-form the target model and support structures.
The present invention providing a real-time positioning ultrasonic system that locates the dental implant drill bit relative to placed reference points or fiducial markers, and guides the drill entry point and angular trajectory, so that drilling is effected in the most optimum location in the jaw bone, as planned based on pre-surgery cone-beam computed tomography scans.
A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereonDental implantsImplanting tools
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61C 1/08 - Machine parts specially adapted for dentistry
A61B 6/14 - Applications or adaptations for dentistry
The present invention providing a real-time positioning ultrasonic system that locates the dental implant drill bit relative to placed reference points or fiducial markers, and guides the drill entry point and angular trajectory, so that drilling is effected in the most optimum location in the jaw bone, as planned based on pre-surgery cone-beam computed tomography scans.
A system for predicting epileptic seizures includes sensors operable to record a wearer's brain activity. The sensors electronically communicate with a processor configured to receive and store output EEG oscillations and activities. A threshold electrical fluctuation level is identified as the level electrical activity experienced at the onset of a seizure event, and is then stored in the PDA memory as a predetermined threshold value. The processor analyzes the input EEG data logged for a recording period, and the logged data is broken into a number of data values across a series of individual set sampling periods. Convert collected data value readings for individual sampling periods as a non-linear measure value using fractal dimension, P&H and/or Lyapunov weighing. The calculated values for a predicted next time intervals extending the sampling period is projected forward and compared against the predetermined threshold value to indicate a likely seizure event.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
48.
Ultrasonic sensor microarray and its method of manufacture
A sensor assembly including one or more capacitive micromachined ultrasonic transducer (CMUT) microarray modules which are provided with a number of individual transducers. The microarray modules are arranged to simulate or orient individual transducers in a hyperbolic paraboloid geometry. The transducers/sensor are arranged in a rectangular or square matrix and are activatable individually, selectively or collectively to emit and received reflected beam signals at a frequency of between about 100 to 170 kHz.
A sensor assembly including one or more capacitive micromachined ultrasonic transducer (CMUT) microarray modules which are provided with a number of individual transducers. The microarray modules are arranged to simulate or orient individual transducers in a hyperbolic paraboloid geometry. The transducers/sensor are arranged in a rectangular or square matrix and are activatable individually, selectively or collectively to emit and received reflected beam signals at a frequency of between about 100 to 170 kHz.
In one aspect, the invention provides a transgenic non-human animal model having germ cells and somatic cells containing an endogenous MMTV-SV40-Spy1A gene sequence introduced into said animal model or an ancestor of said animal model at an embryonic stage, wherein said gene sequence comprises a mouse mammary tumor virus gene (MMTV), a functionally disrupted SV40 gene (SV40) and a human Spy1A gene. In another aspect, the present invention provides a transgenic non-human animal model whose germ cells and somatic cells contain an endogenous Spy1A-pTRE-Tight gene sequence introduced into said animal model or an ancestor of said animal model at an embryonic stage. Preferably, the Spy1A-pTRE-Tight animal model expresses the Spy1A gene and develop cancer, preferably breast cancer, when administered with tetracycline, preferably doxycycline.
A sensor assembly including one or more capacitive micromachined ultrasonic transducer (CMUT) microarray modules which are provided with a number of individual transducers. The transducers/sensor are arranged in a rectangular or square matrix and are provided with a conductive pad positioned in the transducer air gap. The conducive pads are activatable individually, selectively or collectively to emit and received reflected beam signals at a frequency of between about 100 to 170 kHz.
G01D 5/56 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using means specified in two or more of groups , , , , and using electric or magnetic means
G01D 5/24 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance
G01D 5/48 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using wave or particle radiation means
G01S 15/88 - Sonar systems specially adapted for specific applications
G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
NATIONAL RESEARCH COUNCIL OF CANADA (NRC) (Canada)
UNIVERSITY OF WINDSOR (Canada)
Inventor
Sikorska, Marianna
Sandhu, Jagdeep
Pandey, Siyaram
Abstract
Provided herein are compositions and methods for reducing neurogeneration in a patient suffering from Parkinson's Disease, comprising administration of a composition comprising CoQ10 and polyoxyethanyl-a-tocopherylsebacate (PTS). The compositions of the invention have been shown to penetrate the blood-brain barrier in mammals, thus effecting delivery of CoQ10 directly to brain tissue. Beneficial effects of the treatment have been observed at lower doses of CoQ10 than previously described.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
53.
Ultrasonic sensor microarray and method of manufacturing same
A sensor assembly including one or more capacitive micromachined ultrasonic transducer (CMUT) microarray modules which are provided with a number of individual transducers. The transducers include silicon device and backing layers joined by a fused benzocyclobutene (BCB) layer which defines the transducer air gap, and which are arranged to simulate or orient individual transducers in a hyperbolic paraboloid geometry. The transducers/sensor are arranged in a matrix and are activatable to emit and receive reflected beam signals at a frequency of between about 100 to 170 kHz.
A hybrid electro-electroless deposition process whereby multiple metal films layers are deposited from a single plating solution which includes both electroless and electroplating components. The article to be plated is immersed in the solution, and electric current is selectively applied at determined voltages for predetermined times, at selected intervals to effect electroplating in conjunction with electroless deposition. Electroplated metal layers are interspersed with electroless deposited metal layers.
C23C 28/00 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and
C23C 18/16 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by reduction or substitution, i.e. electroless plating
C25D 5/18 - Electroplating using modulated, pulsed or reversing current
55.
Medicament containing taraxacum plant root extract for treatment or prevention of cancer, and method for preparing same
Taraxacum plant root to obtain a frozen root stock, said freezing step being selected to effect at least partial disruption of one or more root cells; dry grinding the frozen root stock to obtain a ground root powder, wherein during said dry grinding step the frozen root stock is maintained at a grinding temperature below about 40° C.; steeping the ground root powder with a solvent to obtain a suspension having a liquid extract portion and a solid particle portion; and separating the liquid extract portion from the solid particle portion to provide a separated liquid extract for use in the medicament.
A stable delivery system for the therapeutic release and application of nitric oxide to a patient suffering from a cutaneous injury or wound includes a S-nitrosothiol and transition element nanoparticles. The transition metal nanoparticles are selected to react with the S-nitrosothiol to release and diffuse nitric oxide into the injury or wound.
A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
A61K 31/43 - Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
A method of processing a metal for improved damping of a metal part is provided. The method comprises placing the metal part inside a current carrying coil and closing a circuit for to apply current to the coil, thus producing a magnetic field in the metal part. Thereafter, the circuit is opened for a time and then the circuit is closed a second time to apply a second current to the coil. The circuit is then opened a second time and the metal part is removed from the current carrying coil.
F16F 1/02 - Springs made of steel or other material having low internal frictionWound, torsion, leaf, cup, ring or the like springs, the material of the spring not being relevant
58.
ULTRASONIC SENSOR MICROARRAY AND ITS METHOD OF MANUFACTURE
A sensor assembly including one or more capacitive micromachined ultrasonic transducer (CMUT) microarray modules which are provided with a number of individual transducers. The microarray modules are arranged to simulate or orient individual transducers in a hyperbolic paraboloid geometry. The transducers/sensor are arranged in a rectangular or square matrix and are activatable individually, selectively or collectively to emit and received reflected beam signals at a frequency of between about 100 to 170 kHz.
G01D 5/48 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using wave or particle radiation means
G01S 7/52 - Details of systems according to groups , , of systems according to group
G01S 15/93 - Sonar systems specially adapted for specific applications for anti-collision purposes
59.
ULTRASONIC SENSOR MICROARRAY AND ITS METHOD OF MANUFACTURE
A sensor assembly including one or more capacitive micromachined ultrasonic transducer (CMUT) microarray modules which are provided with a number of individual transducers. The microarray modules are arranged to simulate or orient individual transducers in a hyperbolic paraboloid geometry. The transducers/sensor are arranged in a rectangular or square matrix and are activatable individually, selectively or collectively to emit and received reflected beam signals at a frequency of between about 100 to 170 kHz.
G01D 5/24 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance
G01D 5/48 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using wave or particle radiation means
G01S 7/52 - Details of systems according to groups , , of systems according to group
G01S 15/931 - Sonar systems specially adapted for specific applications for anti-collision purposes of land vehicles
The present invention provides an optically transparent peroxide cured article made from a peroxide curable butyl rubber ionomer comprising repeating units derived from the reaction product of one or more multiolefin monomers and at least one nitrogen or phosphorous based nucleophile comprising a pendant vinyl group. A process is also disclosed for making the optically transparent article.
C08F 299/00 - Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
C08C 19/24 - Incorporating phosphorus atoms into the molecule
This invention relates to elastomeric coatings for electronics. Disclosed is a electronic device comprising a substrate layer, a conductive layer and an encapsulant layer. The encapsulant layer comprises at least a butyl rubber material. The butyl rubber encapsulant prevents a change in resistivity of the conductive layer following exposure to nitric acid vapour for 12 hours or hydrochloric acid vapour for 10 hours.
B32B 25/18 - Layered products essentially comprising natural or synthetic rubber comprising butyl or halobutyl rubber
B32B 33/00 - Layered products characterised by particular properties or particular surface features, e.g. particular surface coatingsLayered products designed for particular purposes not covered by another single class
Surface modification methods based on a combination of plasma and chemical treatments render an unfilled butyl rubber surface highly reactive toward organosilanes, allowing formation of an organosilane self-assembled monolayer (SAM). Plasma oxidation of the butyl rubber surface followed by vapour deposition of SiCl4 produces a hydrophilic surface suitable for anchoring organosilanes. Fabrication of SAMs on this hydrophilic butyl rubber surface with n-octadecyltrichlorosilane (OTS) and trichloro(1H,1H,2H,2H-perfluorooctyl)silane (FOTS) via vapour deposition resulted in a 15% and 25% decrease in gas permeability, respectively, with no change in optical transparency of the butyl rubber.
A sensor assembly including one or more capacitive micromachined ultrasonic transducer (CMUT) microarray modules which are provided with a number of individual transducers. The microarray modules are arranged to simulate or orient individual transducers in a hyperbolic paraboloid geometry. The transducers/sensor are arranged in a rectangular or square matrix and are activatable individually, selectively or collectively to emit and received reflected beam signals at a frequency of between about 100 to 170 kHz.
G01D 5/24 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance
B06B 1/02 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy
G01S 15/93 - Sonar systems specially adapted for specific applications for anti-collision purposes
64.
Ultrasonic sensor microarray and method of manufacturing same
A sensor assembly including one or more capacitive micromachined ultrasonic transducer (CMUT) microarray modules which are provided with a number of individual transducers. The microarray modules are arranged to simulate or orient individual transducers in a hyperbolic paraboloid geometry. The transducers/sensor are arranged in a rectangular or square matrix and are activatable individually, selectively or collectively to emit and received reflected beam signals at a frequency of between about 100 to 170 Hz.
In one aspect, the invention provides a transgenic non-human animal model havings germ cells and somatic cells containing an endogenous MMTV-SV40-Spy1A gene sequence introduced into said animal model or an ancestor of said animal model at an embryonic stage, wherein said gene sequence comprises a mouse mammary tumor virus gene (MMTV), a functionally disrupted SV40 gene (SV40) and a human Spy1A gene. In another aspect, the present invention provides a transgenic non-human animal model whose germ cells and somatic cells contain an endogenous Spy1A-pTRE-Tight gene sequence introduced into said animal model or an ancestor of said animal model at an embryonic stage. Preferably, the Spy1A-pTRE-Tight animal model expresses the Spy1A gene and develop cancer, preferably breast cancer, when administered with tetracycline, preferably doxycycline.
A pathogen detection system including a specimen support for supporting a test specimen sample to be analyzed, a coherent light source, an optical detector and an analyzer electronically coupled to the optical detection. The coherent light source is operable to direct a coherent light beam at said specimen support to break down and at least partially atomize said test specimen sample. The optical detector is positioned to detect a spectral signature of electromagnetic radiation emitted by the partial atomization of the test specimen sample. The analyzer compares the detected spectral signature to one or more predetermined spectral signatures for one or more pathogens.
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
G01N 21/71 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
67.
Apparatus for the automated testing and validation of electronic components
An automatic test equipment (ATE) unit, which incorporates a mass interconnect system. The mass interconnect system is provided with a universal mounting table for use with receiver and test interface modules for electronically mounting and testing a variety of different types of electronic components or unit under test thereon. The mounting table test interface module incorporates MEMS based spring contacts to provide high-speed micro test-channels in order to establish signal connectivity between the components or unit under test and the tester, and which maintain the signal integrity up to 50 GHz without significant signal loss distortion.
G01R 31/00 - Arrangements for testing electric propertiesArrangements for locating electric faultsArrangements for electrical testing characterised by what is being tested not provided for elsewhere
G01R 1/04 - HousingsSupporting membersArrangements of terminals
The present invention relates to an improved method for preparing a medicament comprising a Taraxacum plant root extract for the treatment or prevention of a cancer. In one aspect, the method comprises freezing Taraxacum plant root to obtain a frozen root stock, said freezing step being selected to effect at least partial disruption of one or more root cells; dry grinding the frozen root stock to obtain a ground root powder, wherein during said dry grinding step the frozen root stock is maintained at a grinding temperature below about 40°C; steeping the ground root powder with a solvent to obtain a suspension having a liquid extract portion and a solid particle portion; and separating the liquid extract portion from the solid particle portion to provide a separated liquid extract for use in the medicament.
The present invention relates to an improved method for preparing a medicament comprising a Taraxacum plant root extract for the treatment or prevention of a cancer. In one aspect, the method comprises freezing Taraxacum plant root to obtain a frozen root stock, said freezing step being selected to effect at least partial disruption of one or more root cells; dry grinding the frozen root stock to obtain a ground root powder, wherein during said dry grinding step the frozen root stock is maintained at a grinding temperature below about 40°C; steeping the ground root powder with a solvent to obtain a suspension having a liquid extract portion and a solid particle portion; and separating the liquid extract portion from the solid particle portion to provide a separated liquid extract for use in the medicament.
A radar system (100) is described including a transmitting assembly (10), a receiving assembly (20), a control unit (30) and a signal processing unit (40). The transmitting assembly (10) receives an input signal (31) and transmits an incident radar signal (2). The transmitting assembly (10) includes a Rotman lens (12) having a lens cavity (74), a plurality of beam ports (60), a plurality of array ports (62) and a patch antenna assembly (14). The lens cavity (74) has a lens gap (h) between 10 microns to 120 microns, and preferably 40 microns to 60 microns. The patch antenna assembly (14) includes a plurality of antenna arrays (130) operable to receive a plurality of time-delayed, in-phase signals from the Rotman lens (12) and to transmit the incident radar signal (2) towards a target (4). The receiving assembly (20) receives a reflected radar signal (6) and produces an output signal. The signal processing unit (40) compares the input signal (31) to the output signal and implements an algorithm determining the range, velocity and position of the target (4).
H01Q 15/02 - Refracting or diffracting devices, e.g. lens, prism
H01Q 19/06 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using refracting or diffracting devices, e.g. lens
H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
G01S 13/34 - Systems for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated using transmission of continuous, frequency-modulated waves while heterodyning the received signal, or a signal derived therefrom, with a locally-generated signal related to the contemporaneously transmitted signal
G01S 13/42 - Simultaneous measurement of distance and other coordinates
G01S 13/58 - Velocity or trajectory determination systemsSense-of-movement determination systems
G01S 13/93 - Radar or analogous systems, specially adapted for specific applications for anti-collision purposes
H01Q 1/34 - Adaptation for use in or on ships, submarines, buoys or torpedoes
H01Q 25/00 - Antennas or antenna systems providing at least two radiating patterns
G01S 7/00 - Details of systems according to groups , ,
G01S 13/00 - Systems using the reflection or reradiation of radio waves, e.g. radar systemsAnalogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
H01Q 15/00 - Devices for reflection, refraction, diffraction or polarisation of waves radiated from an antenna, e.g. quasi-optical devices
H01Q 19/00 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic
G01S 13/02 - Systems using reflection of radio waves, e.g. primary radar systemsAnalogous systems
71.
System and method for determining fluid flow of compressible and non-compressible liquids
A system and method for determining fluid flow of compressible and non-compressible liquids includes an input receiving an object model defined as a plurality of cells having nodes, a processor and memory. The processor is configured for: discretizing a partial differential equation (PDE) corresponding to the received model; for each node P: (i) locating all neighboring cells that share the node P; establish a finite difference stencil at each cell center, and identify stencil intersection points with cell boundary edges; calculate an approximate solution of the PDE at the intersection points; (ii) approximating the PDE at the cell center of the neighboring cells using the stencil and discretized PDE; and (iii) updating a solution of the PDE at the node P by using the solution of approximated discretized PDE at all the neighboring cell centers; and iteratively updating the solution for all nodes P from an initial guess until a convergence criterion is satisfied.
G06F 7/60 - Methods or arrangements for performing computations using a digital non-denominational number representation, i.e. number representation without radixComputing devices using combinations of denominational and non-denominational quantity representations
An automatic test equipment (ATE) unit, which incorporates a mass interconnect system. The mass interconnect system is provided with a universal mounting table for use with receiver and test interface modules for electronically mounting and testing a variety of different types of electronic components or unit under test thereon. The mounting table test interface module incorporates MEMS based spring contacts to provide high-speed micro test-channels in order to establish signal connectivity between the components or unit under test and the tester, and which maintain the signal integrity up to 50 GHz without significant signal loss distortion.
An automatic test equipment (ATE) unit, which incorporates a mass interconnect system. The mass interconnect system is provided with a universal mounting table for use with receiver and test interface modules for electronically mounting and testing a variety of different types of electronic components or unit under test thereon. The mounting table test interface module incorporates MEMS based spring contacts to provide high-speed micro test-channels in order to establish signal connectivity between the components or unit under test and the tester, and which maintain the signal integrity up to 50 GHz without significant signal loss distortion.
A stable delivery system for the therapeutic release and application of nitric oxide to a patient suffering from a cutaneous injury or wound includes a S-nitrosothiol and transition element nanoparticles. The transition metal nanoparticles are selected to react with the S- nitrosothiol to release and diffuse nitric oxide into the injury or wound.
A61F 13/40 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators having means integral therewith for supplying media to the absorbent material, e.g. contained in a rupturable reservoir
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 33/00 - Medicinal preparations containing inorganic active ingredients
A stable delivery system for the therapeutic release and application of nitric oxide to a patient suffering from a cutaneous injury or wound includes a S-nitrosothiol and transition element nanoparticles. The transition metal nanoparticles are selected to react with the S- nitrosothiol to release and diffuse nitric oxide into the injury or wound.
A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
A61F 13/40 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators having means integral therewith for supplying media to the absorbent material, e.g. contained in a rupturable reservoir
A61K 9/00 - Medicinal preparations characterised by special physical form
A plating process using an electroless plating bath formed from two separate prepared component solutions. The component solutions mixed within 120 hours prior to plating operations, to provide a highly alkaline plating bath solution. One component solution of the two-part plating bath, is provided with a metal salt or source of plating ions, and which is initially kept in a separate solution from the second other prepared component solution. The second component solution contains formaldehyde, and preferably paraformaldehyde, used to reduce the metal salts into the metal to be deposited on a substrate. Each component solution further includes sodium hydroxide in concentrations selected so that when the two solutions are preferably mixed the final plating bath solution has a pH greater than 11.5.
A method of processing a metal for improved damping of a metal part is provided. The method comprises placing the metal part inside a current carrying coil and closing a circuit for to apply current to the coil, thus producing a magnetic field in the metal part. Thereafter, the circuit is opened for a time and then the circuit is closed a second time to apply a second current to the coil. The circuit is then opened a second time and the metal part is removed from the current carrying coil.
A radar system (100) is described including a transmitting assembly (10), a receiving assembly (20), a control unit (30) and a signal processing unit (40). The transmitting assembly (10) receives an input signal (31) and transmits an incident radar signal (2). The transmitting assembly (10) includes a Rotman lens (12) having a lens cavity (74), a plurality of beam ports (60), a plurality of array ports (62) and a patch antenna assembly (14). The lens cavity (74) has a lens gap (h) between 10 microns to 120 microns, and preferably 40 microns to 60 microns. The patch antenna assembly (14) includes a plurality of antenna arrays (130) operable to receive a plurality of time- delayed, in-phase signals from the Rotman lens (12) and to transmit the incident radar signal (2) towards a target (4). The receiving assembly (20) receives a reflected radar signal (6) and produces an output signal. The signal processing unit (40) compares the input signal (31) to the output signal and implements an algorithm determining the range, velocity and position of the target (4).
H01H 36/00 - Switches actuated by change of magnetic field or of electric field, e.g. by change of relative position of magnet and switch, by shielding
H01Q 1/38 - Structural form of radiating elements, e.g. cone, spiral, umbrella formed by a conductive layer on an insulating support
H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
A radar system (100) is described including a transmitting assembly (10), a receiving assembly (20), a control unit (30) and a signal processing unit (40). The transmitting assembly (10) receives an input signal (31) and transmits an incident radar signal (2). The transmitting assembly (10) includes a Rotman lens (12) having a lens cavity (74), a plurality of beam ports (60), a plurality of array ports (62) and a patch antenna assembly (14). The lens cavity (74) has a lens gap (h) between 10 microns to 120 microns, and preferably 40 microns to 60 microns. The patch antenna assembly (14) includes a plurality of antenna arrays (130) operable to receive a plurality of time- delayed, in-phase signals from the Rotman lens (12) and to transmit the incident radar signal (2) towards a target (4). The receiving assembly (20) receives a reflected radar signal (6) and produces an output signal. The signal processing unit (40) compares the input signal (31) to the output signal and implements an algorithm determining the range, velocity and position of the target (4).
H01H 36/00 - Switches actuated by change of magnetic field or of electric field, e.g. by change of relative position of magnet and switch, by shielding
H01Q 1/38 - Structural form of radiating elements, e.g. cone, spiral, umbrella formed by a conductive layer on an insulating support
H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
80.
Kinetic energy dissipation system for dissipating kinetic shock energy
An energy dissipation assembly is provided for mounting between a fixed support and moveable support. The assembly includes a sacrificial deformation tube, a hardened cutter/deflector assembly and, optionally, a connecting cable to maintain the cutter/deflector assembly in juxtaposed coaxial alignment with an end deformation tube. The cutter/deflector assembly has a generally flattened disc shaped profile and includes a central hub, a circular support ring and one or more cutting blades. The support ring is concentrically about the hub and has an inner diameter greater than the outer tube diameter. On the occurrence of a shock force, the cutter/deflector assembly moves axial to cut/deform the deformation tube to dissipate force energy.
B60R 19/42 - Bumpers, i.e. impact receiving or absorbing members for protecting vehicles or fending off blows from other vehicles or objects extending primarily along the sides of, or completely encircling, a vehicle
An energy dissipation assembly is provided for mounting between a fixed support and moveable support. The assembly includes a sacrificial deformation tube, a hardened cutter/deflector assembly and, optionally, a connecting cable to maintain the cutter/deflector assembly in juxtaposed coaxial alignment with an end deformation tube. The cutter/deflector assembly has a generally flattened disc shaped profile and including a central hub, a circular support ring and one or more cutting blades. The support ring concentrically about the hub and has an inner diameter greater than the outer tube diameter. On the occurrence of a shock force, the cutter/deflector assembly moves axially to cut/deform the deformation tube to dissipate force energy.
The present invention provides the following new polymers which are useful for hydrogen storage: (i) a polymer comprising -[MN2]- as a repeating unit, wherein M is selected from the group consisting Sc, Ti, V, Cr, Mn, Fe, Co, Zr, Nb, Mo, and mixtures thereof; and (ii) a polymer comprising -[M2N3]- as a repeating unit, wherein M is selected from the group consisting Sc, Ti, V, Cr, Mn, Fe, Co, Zr, Nb, Mo, and mixtures thereof.
C07F 9/00 - Compounds containing elements of Groups 5 or 15 of the Periodic Table
C08G 79/00 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon
F02K 9/08 - Rocket-engine plants, i.e. plants carrying both fuel and oxidant thereforControl thereof using solid propellants
C01B 3/00 - HydrogenGaseous mixtures containing hydrogenSeparation of hydrogen from mixtures containing itPurification of hydrogen
Spy1A is a cyclin-like protein required for progression through the Gj/S phase of the cell cycle. Overexpression of Spy1A is sufficient to override the DNA damage response and to support enhanced cell proliferation; accordingly aberrant levels of this protein have been implicated in tumorigenesis. Understanding how Spy1A is produced and degraded is essential in resolving how it contributes to normal and abnormal growth processes. Herein, we demonstrate that Spy1A is degraded in a cell-cycle-dependent manner via the ubiquitin-proteasome system. We have resolved that the E3 ligase mediating degradation during the somatic cell cycle is in fact Nedd4, a protein responsible for the degradation of several important cellular oncogenes and tumor suppressor genes. In addition, we have identified the phosphorylation sites on Spy1A which mediate its degradation and we have resolved that non-degradable forms of Spy1A do not trigger cell cycle arrest but rather contribute to uncontrolled cell growth. Importantly, this work connects two proteins previously implicated in carcinogenesis, Spy1A and Nedd4. Further investigation into the regulation of Spy1lA may reveal novel strategies for understanding the etiology and progression of specific growth disorders. Aberrant levels Spy1A protein have been implicated in, many forms of cancer, developmental disorders, neurodegenerative disorders, diabetes and are attributed to overriding the DNA damage response and enhancing cell proliferation. Understanding how Spy1A is produced and degraded is essential in resolving how it contributes to normal and abnormal growth process, this process represents a novel mechanism for the development of agents and therapeutic treatments for these disorders. These technologies also represent effective strategies for regenerative medicine. Furthermore, protein levels of Spy1A represent a valuable diagnostic and prognostic marker for many forms of cancer, development disorders, neurodegenerative disorders and diabetes applicable to all vertebrates.
An ultrasonic device evaluates the sound velocity of a nail to determine the overall health of a patient and to monitor cosmetological effects of certain products on the nail. The ultrasonic device includes a handhold probe having an piezoelectric transducer encased in cover that emits high-frequency ultrasonic impulses directed towards the nail. The nail reflects returning ultrasonic echoes back to the piezoelectric transducer. The returning ultrasonic echoes vibrate the piezoelectric transducer. A processor of a computer converts the vibrations into electrical pulses. The processor evaluates amplitude values of the electrical pulses to determine the parameters of the human nail, including the thickness, density and elasticity. The parameters are displayed on a display and analyzed by a technician to determine the nail condition. The health of the person or the effect of products on the nail can be determined based on the nail parameters.
An ultrasonic device evaluates the sound velocity of a nail to determine the overall health of a patient and to monitor cosmetological effects of certain products on the nail. The ultrasonic device includes a handhold probe having an piezoelectric transducer encased in cover that emits high-frequency ultrasonic impulses directed towards the nail. The nail reflects returning ultrasonic echoes back to the piezoelectric transducer. The returning ultrasonic echoes vibrate the piezoelectric transducer. A processor of a computer converts the vibrations into electrical pulses. The processor evaluates amplitude values of the electrical pulses to determine the parameters of the human nail, including the thickness, density and elasticity. The parameters are displayed on a display and analyzed by a technician to determine the nail condition. The health of the person or the effect of products on the nail can be determined based on the nail parameters.
Single-domain antibodies that bind pro-apoptotic proteins Bax and caspase-3 are identified and isolated. These single-domain antibodies may be used to modulate the activity of Bax and caspase-3, thereby modulating the symptoms and steps of oxidative stress and/or cell apoptosis, including Bax dimerization, mitochondrial permeabilization and the release of apoptotic proteins.
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
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