University of Delaware

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C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule 7
A61P 35/00 - Antineoplastic agents 6
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings 6
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1.

TWO PHASE FLOWS FOR REACTIONS AND SEPARATIONS

      
Application Number 18675478
Status Pending
Filing Date 2024-05-28
First Publication Date 2025-12-04
Owner University of Delaware (USA)
Inventor
  • Baker-Fales, Montgomery
  • Vlachos, Dionisios G.

Abstract

Disclosed herein is a method for designing a liquid-liquid biphasic micro-fluidic flow channel reactor for continuous extraction or reactive extraction, where chemistry happens in one phase and the product is removed to the other. The method comprises developing random forest and symbolic genetic regression machine learning (ML) models to predict flow patterns and the mass transfer rate, respectively, using a combination of experimental and computational fluid dynamics (CFD) data and literature-mined data while accounting for the effects of solvent properties and channel diameter. This enables rapid prediction for efficient scale-up of microchannels to millichannels. To minimize the number of CFD simulations and maximize model accuracy, the method comprises using active learning techniques.

IPC Classes  ?

  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
  • B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
  • B01J 19/24 - Stationary reactors without moving elements inside

2.

UNIVERSITY OF DELAWARE

      
Application Number 1889289
Status Registered
Filing Date 2025-10-10
Registration Date 2025-10-10
Owner University of Delaware (USA)
NICE Classes  ? 41 - Education, entertainment, sporting and cultural services

Goods & Services

Educational services, namely, providing courses of instruction at the college level; educational services, namely, providing on-line courses of instruction at the college level.

3.

DEVICES, METHODS, AND SYSTEMS FOR COLLECTING AQUATIC FIELD METABOLIC RATE DATA

      
Application Number 18874111
Status Pending
Filing Date 2023-06-13
First Publication Date 2025-11-27
Owner University of Delaware (USA)
Inventor
  • Dohner, Stephanie Marie
  • Carlisle, Aaron Ball
  • Cohen, Jonathan Hirsch
  • Trembanis, Arthur C.
  • Leontiou, Andrea

Abstract

A device collects aquatic field metabolic rate data related to a water-breathing animal having at least one gill opening. The device has at least one oxygen probe, which measures and records oxygen consumption or oxygen extraction data at the at least one gill opening. The device is configured to collect metabolic data when the animal is in a natural environment. A method for determining a metabolic rate of the animal located in a water environment includes measuring metabolic rate data via at least one gill oxygen probe which is inserted into the at least one gill opening; measuring ambient data in the water environment via at least one ambient oxygen probe; and estimating a whole animal metabolic rate.

IPC Classes  ?

  • A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

4.

BIO-NANOSHELLS AND METHODS FOR PREPARATION AND APPLICATIONS THEREOF

      
Application Number 19086533
Status Pending
Filing Date 2025-03-21
First Publication Date 2025-09-25
Owner University of Delaware (USA)
Inventor
  • Day, Emily Shannon
  • Aboeleneen, Sara

Abstract

The present invention provides a bio-nanoshell for binding specifically to a target cell. The bio-nanoshell may comprise a cell-derived biological membrane from a donor cell and a nanoshell having an exterior surface coated with the cell-derived biological membrane. The cell-derived biological membrane may comprise a phospholipid bilayer and an adhesion protein specific for the target cell. Also provided is a method for preparing the bio-nanoshells and a method for delivering the bio-nanoshells to target cells.

IPC Classes  ?

  • A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
  • A61K 9/51 - Nanocapsules
  • A61P 35/00 - Antineoplastic agents

5.

IMPROVED PLASTIC DEGRADATION BY DARKLING BEETLE LARVAE, MICROBES, AND ENZYMES

      
Application Number 18861356
Status Pending
Filing Date 2023-04-28
First Publication Date 2025-09-18
Owner University of Delaware (USA)
Inventor
  • Blenner, Mark
  • Solomon, Kevin
  • Monteiro, Lummy
  • Singh, Jyoti
  • Klauer, Ross

Abstract

The invention provides a method for improving degradation of a plastic substrate. The improvement method comprises treating darkling beetle larvae (e.g., mealworms) with a feed supplemented with one or more dietary supplements, for example, oats, and exposing a plastic substrate to an effective amount of the darkling beetle larvae. Also provided are methods for degrading a plastic substrate using a microorganism isolated from the darkling beetle larvae (e.g., mealworms) or an enzyme, for example, a peroxidase.

IPC Classes  ?

6.

INTERACTIVE MUSICAL INTERFACE TO ENHANCE FORMATIVE LISTENING EXPERIENCES FOR CHILDREN WITH AUTISM SPECTRUM DISORDER

      
Application Number 19201395
Status Pending
Filing Date 2025-05-07
First Publication Date 2025-08-21
Owner University of Delaware (USA)
Inventor
  • Mauriello, Matthew
  • Stevens, Daniel
  • Ruggiero, Elise
  • Karwankar, Abhishek

Abstract

An interactive audio control device having a user interface, the user interface having a plurality of selectable user input elements, each selectable user input element having an audio playback control corresponding to a predetermined audio layer of a selected multi-layer music track or a playback operation, wherein each selectable user input corresponding to a predetermined audio layer is configured to select from a plurality of playback modes corresponding to the predetermined audio layer and to provide a visual indication corresponding to the selected playback mode.

IPC Classes  ?

  • G06F 3/16 - Sound inputSound output
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06F 3/04817 - Interaction techniques based on graphical user interfaces [GUI] based on specific properties of the displayed interaction object or a metaphor-based environment, e.g. interaction with desktop elements like windows or icons, or assisted by a cursor's changing behaviour or appearance using icons
  • G06F 3/0482 - Interaction with lists of selectable items, e.g. menus
  • G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
  • G06F 3/0487 - Interaction techniques based on graphical user interfaces [GUI] using specific features provided by the input device, e.g. functions controlled by the rotation of a mouse with dual sensing arrangements, or of the nature of the input device, e.g. tap gestures based on pressure sensed by a digitiser

7.

PROCESS AND SYSTEM FOR ADDITIVE MANUFACTURING OF CARBON SCAFFOLDS

      
Application Number 18857615
Status Pending
Filing Date 2023-04-20
First Publication Date 2025-08-21
Owner University of Delaware (USA)
Inventor
  • Fu, Kun
  • Zhang, Chunyan

Abstract

A process for additive manufacturing of a nanocomposite is disclosed. The process includes providing a uniform filament comprising a carbon fiber material and a polymer binder; dispensing the uniform filament to form a preform architecture that defines a first 3-dimensional bulk structure having a first set of volume-defining dimensions; heating the preform architecture to remove the polymer binder, thereby forming a porous carbon scaffold; and incorporating a matrix material into the porous carbon scaffold to form a third 3-dimensional bulk structure. The carbon scaffold defines a second 3-dimensional bulk structure having a second bulk volume, wherein the second bulk volume is equal to the first bulk volume within a tolerance of 10%. A system for additive manufacturing of a fiber reinforced composite is also disclosed. The system has a filament dispenser; means for moving the filament dispenser; a heater; and a matrix material applicator.

IPC Classes  ?

  • B28B 1/00 - Producing shaped articles from the material
  • B28B 11/00 - Apparatus or processes for treating or working the shaped articles
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
  • B33Y 40/20 - Post-treatment, e.g. curing, coating or polishing
  • C08J 5/24 - Impregnating materials with prepolymers which can be polymerised in situ, e.g. manufacture of prepregs

8.

MEDIUM AND DEVICE FOR PROTEOMIC SAMPLE PREPARATION

      
Application Number 18859334
Status Pending
Filing Date 2023-04-27
First Publication Date 2025-08-21
Owner UNIVERSITY OF DELAWARE (USA)
Inventor Yu, Yanbao

Abstract

The invention provides a medium. The medium comprises a fibrous matrix and silica microparticles immobilized in the fibrous matrix. The fibrous matrix may comprise glass fibers, polyolefin fibers, polyvinylidene fluoride (PVDF) fibers, polytetrafluoroethylene (PTFE) fibers, polypropylene fibers, polyethylene fibers, aramid fibers, natural cellulosic fibers, or a combination thereof. A composition comprising the medium is provided. A device comprising the medium or the composition is also provided. Further provided are methods for preparing a proteomic sample from a biological sample on the medium. The biological sample comprises cells or proteins. The method may comprise a treating step, a digesting step, a reducing and alkylating step, and an eluting step. All of these steps may be performed on the medium. The proteomic sample comprises the eluted peptides. The proteomic sample may be desalted. The peptides prepared from the biological sample may be suitable for qualitative or quantitative analysis, for example, mass spectrometric analysis.

IPC Classes  ?

9.

L-THREONINE TRANSALDOLASES AND USES THEREOF

      
Application Number 18847362
Status Pending
Filing Date 2023-03-17
First Publication Date 2025-07-03
Owner University of Delaware (USA)
Inventor
  • Kunjapur, Aditya
  • Jones, Michaela
  • Butler, Neil
  • Wirt, Sean

Abstract

The invention provides a method for producing in vitro a beta-hydroxy non-standard amino acid (0-OH-nsAA). The in vitro method comprises incubating L-threonine, an aldehyde and an L-threonine transaldolase (TTA). Also provided is a method for producing a beta-hydroxy non-standard amino acid (0-OH-nsAA) by recombinant cells, comprising expressing a heterologous L-threonine transaldolase (TTA) by the recombinant cells, and growing the recombinant cells in a medium. The medium comprises L-threonine and an aldehyde.

IPC Classes  ?

10.

ENGINEERED EXTRACELLULAR VESICLES FOR TARGETED DRUG DELIVERY TO MUSCLE

      
Application Number 18848245
Status Pending
Filing Date 2023-03-23
First Publication Date 2025-06-26
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Shuler, Kyle
  • Mitchell, Andrew
  • Muñoz, Eric
  • Sperduto, John
  • Hudson, Matthew

Abstract

The invention relates to myotropic extracellular vesicle compositions comprising a muscle-targeting membrane protein and optionally one or more therapeutic agents. The invention further relates to methods of using the myotropic extracellular vesicles comprising a muscle-targeting membrane protein for therapeutic applications for treating muscular disorders, conditions, and damage in a subject.

IPC Classes  ?

  • A61K 9/50 - Microcapsules
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

11.

THERMO-RESPONSIVE AND CONDUCTING POLYMER WITH A REVERSIBLE SOL-GEL TRANSITION

      
Application Number 18847860
Status Pending
Filing Date 2023-03-17
First Publication Date 2025-06-19
Owner University of Delaware (USA)
Inventor
  • Kayser, Laure V.
  • Damani, Vidhika S.

Abstract

Disclosed herein is a composition comprising a block copolymer-polyelectrolyte complex. The block copolymer-polyelectrolyte complex comprises a water-insoluble polycationic doped conducting polymer substantially homogeneously dispersed throughout a block-copolymer. The block-copolymer comprises at least one thermo-responsive polymeric block and at least one water-soluble polyanionic polymeric block comprising a plurality of negatively charged moieties. The water-insoluble polycationic doped conducting polymer comprises a plurality of positively charged moieties, such that at least a portion of the positively charged moieties form an ionic bond with at least a portion of the negatively charged moieties throughout the block copolymer-polyelectrolyte complex.

IPC Classes  ?

  • C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
  • C08J 3/075 - Macromolecular gels
  • H01M 4/02 - Electrodes composed of, or comprising, active material

12.

ORDERING NODES FOR TENSOR NETWORK CONTRACTION BASED QUANTUM COMPUTING SIMULATION

      
Application Number 19055021
Status Pending
Filing Date 2025-02-17
First Publication Date 2025-06-12
Owner
  • UNIVERSITY OF DELAWARE (USA)
  • Argonne National Laboratory (USA)
Inventor
  • Safro, Ilya
  • Ibrahim, Cameron
  • Alexeev, Yuri
  • Lykov, Danil

Abstract

A classical computer includes a classical processor and a classical memory coupled to the classical processor. The classical memory includes a gate-graph conversion array, which itself includes at least one correspondence between a conversion quantum gate and a conversion graphical representation. The classical memory further includes classical programming in the classical memory. Execution of the classical programming configures the classical computer to perform the following functions. Receive a plurality of quantum circuit input files, where each quantum circuit input file includes a quantum circuit comprising an input quantum gate. Convert each quantum circuit into a tensor graph by utilizing the gate-graph conversion array. Evaluate the tensor graph as a contraction tree. Output a selected quantum circuit input file of the plurality of quantum circuit input files, with a potential to demonstrate quantum advantage over one or more non-selected quantum circuit input files of the plurality of quantum circuit input files.

IPC Classes  ?

  • G06N 10/80 - Quantum programming, e.g. interfaces, languages or software-development kits for creating or handling programs capable of running on quantum computersPlatforms for simulating or accessing quantum computers, e.g. cloud-based quantum computing

13.

METHODS FOR MAKING A GENETICALLY ENGINEERED ORGANISM EXCLUSIVELY COMMUNICATE TO OR RELY ON ANOTHER ENGINEERED ORGANISM

      
Application Number US2024058838
Publication Number 2025/122849
Status In Force
Filing Date 2024-12-06
Publication Date 2025-06-12
Owner
  • UNIVERSITY OF DELAWARE (USA)
  • STANFORD UNIVERSITY (USA)
Inventor
  • Kunjapur, Aditya
  • Forti, Amanda
  • Jones, Michaela
  • Brophy, Jennifer
  • Zhong, Vivian
  • Cabales, Avaniek
  • Gevorgyan, Alice

Abstract

The present invention provides a method of enabling growth, survival, or a biological function of a recombinant utilizer organism. The growth, survival or biological activity of the recombinant utilizer organism depends on a non-standard amino acid (nsAA). 5 The method comprises: (a) providing a system comprising the recombinant utilizer organism and a recombinant producer organism, wherein the system lacks the nsAA and is not supplemented externally with the nsAA; (b) producing the nsAA by the recombinant producer organism into the system; and (c) incubating the recombinant utilizer organism in the system after step (b).

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12P 13/04 - Alpha- or beta-amino acids
  • C12P 21/00 - Preparation of peptides or proteins
  • C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

14.

DEPOLYMERIZATION OF POLYURETHANES: REGENERATION OF ISOCYANATES VIA CHEMICAL RECYCLING

      
Application Number 18845271
Status Pending
Filing Date 2023-03-09
First Publication Date 2025-06-05
Owner University of Delaware (USA)
Inventor
  • Nandi, Mridula
  • O'Dea, Robert M.
  • Epps, Thomas H.
  • Korley, Lashanda T.J.

Abstract

The present invention discloses a one-step polyurethane (PU) depolymerization to recover isocyanates and regenerate both thermoplastic and thermoset PUs. The method uses a halide-containing boron compound to depolymerize PUs directly to isocyanates under mild conditions (e.g., <100° C. in toluene). Also, disclosed herein is depolymerization of both model and commercially available PUs and regeneration of PUs using recovered isocyanates, with molecular weight distributions and thermomechanical properties that are equivalent to virgin PUs with yields of up to 50%.

IPC Classes  ?

  • C08J 11/22 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material by treatment with organic oxygen-containing compounds
  • C07C 263/20 - SeparationPurification
  • C08G 18/81 - Unsaturated isocyanates or isothiocyanates

15.

OPTICAL COUPLING SYSTEMS AND METHODS FOR MANUFACTURING SAME

      
Application Number US2024030951
Publication Number 2025/116965
Status In Force
Filing Date 2024-05-24
Publication Date 2025-06-05
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Gu, Tingyi
  • Mirotznik, Mark
  • Gupta, Ellen
  • Rahim, Masudur
  • Zhao, Haixin

Abstract

Semiconductor chips including microlens arrays, and methods for forming microlens arrays, are disclosed. A semiconductor chip includes at least one optical coupler and a microlens array. The at least one optical coupler is formed on a surface of the semiconductor chip. The microlens array is formed on the surface of the semiconductor chip covering the at least one optical coupler. A method for forming a microlens array includes identifying a location of at least one optical coupler on a surface of a semiconductor chip, dispensing optical material on the surface of the semiconductor chip at the location of the at least one optical coupler in a shape of a microlens array, and curing the optical material to form the microlens array.

IPC Classes  ?

  • G02B 6/42 - Coupling light guides with opto-electronic elements
  • B29D 11/00 - Producing optical elements, e.g. lenses or prisms

16.

PATTERNED PROBE STRUCTURES, METHODS FOR FABRICATION, AND MICRO-MECHANICAL SPRING SYSTEMS CONTAINING THE SAME

      
Application Number US2024056056
Publication Number 2025/106767
Status In Force
Filing Date 2024-11-15
Publication Date 2025-05-22
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Herrmann, Eric
  • Wang, Xi

Abstract

A method of fabricating a plurality of patterned probes includes steps of depositing a plurality of layers on a substrate; exposing the plurality of layers including includes a silicon-containing film and a non-silicon bilayer resist, thereby forming at least one intermediary nanostructure arran 5 ged in a pattern; depositing a hard mask layer on the plurality of layers; performing a liftoff of portions of the hard mask layer, thereby forming a sample; placing the sample into a chamber; flowing etching gas including fluorine compound etching gas into the chamber; and etching portions of the sample to form the plurality of patterned probes distributed across the substrate. Each 10 patterned probe includes a sidewall profile having a first portion between an attachment to the substrate and an inflection region, and a second portion between the inflection region and a distal end, and the first portion and the second portion have different profile characteristics.

IPC Classes  ?

  • B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
  • B82Y 40/00 - Manufacture or treatment of nanostructures
  • H01L 21/027 - Making masks on semiconductor bodies for further photolithographic processing, not provided for in group or
  • G01J 5/46 - Radiation pyrometry, e.g. infrared or optical thermometry using radiation pressure or radiometer effect

17.

MICROWAVE-ASSISTED CATALYTIC PYROLYSIS PROCESS AND REACTOR FOR SELECTIVELY CONVERTING ADDITIVE-CONTAINING PLASTIC ALKENES AND ALKANES

      
Application Number 18948419
Status Pending
Filing Date 2024-11-14
First Publication Date 2025-04-24
Owner University of Delaware (USA)
Inventor
  • Selvam, Esun
  • Kots, Pavel
  • Chen, Weiqi
  • Vlachos, Dionisios G.
  • Ngu, Jacqueline
  • Najmi, Sean
  • Vance, Brandon

Abstract

The present disclosure provides a pyrolysis process for converting an additive-containing plastic comprising a polyolefin polymer to an alkene, an alkane, or a mixture thereof. The process comprises contacting the plastic with a catalyst in a one-pot pyrolysis system at a temperature between about 350° C. and about 500° C.; wherein the catalyst comprises a solid acid selected from the group consisting of HY, HZSM-5, and Al-SBA-15. The present disclosure further provides a one-pot pyrolysis system and uses of a solid acid in the pyrolysis process for converting plastic comprising a polyolefin polymer to an alkene.

IPC Classes  ?

  • C10G 1/02 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal by distillation
  • B01J 6/00 - CalciningFusing
  • B01J 23/30 - Tungsten
  • B01J 27/182 - PhosphorusCompounds thereof with silicon
  • B01J 29/04 - Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites, pillared clays
  • B01J 29/12 - Noble metals
  • B01J 29/76 - Iron group metals or copper
  • B01J 37/02 - Impregnation, coating or precipitation
  • B01J 37/08 - Heat treatment

18.

Super-semiconductors based on nanostructured arrays

      
Application Number 18864780
Grant Number 12317575
Status In Force
Filing Date 2023-05-11
First Publication Date 2025-04-03
Grant Date 2025-05-27
Owner University of Delaware (USA)
Inventor
  • Wei, Bingqing
  • Li, Zhigang

Abstract

−7 ohm*m at a temperature of 300K+/−40K.

IPC Classes  ?

  • H10F 30/22 - Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation the devices having only one potential barrier, e.g. photodiodes
  • H10D 8/30 - Point-contact diodes
  • H10D 64/20 - Electrodes characterised by their shapes, relative sizes or dispositions
  • H10D 64/62 - Electrodes ohmically coupled to a semiconductor

19.

SOLID-STATE, SINGLE-ION-CONDUCTING, POLYMER BLEND ELECTROLYTES WITH IMPROVED IONIC CONDUCTIVITY

      
Application Number US2024047404
Publication Number 2025/064618
Status In Force
Filing Date 2024-09-19
Publication Date 2025-03-27
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Yang, Mengying
  • Epps, Thomas, H.

Abstract

The present disclosure provides compositions that include one or more of the following: (i) a glassy single-ion conducting (SIC) polymer containing an anionic moiety chemically bound to the glassy SIC polymer and a mobile cation; (li) a flexible ion¬ conducting polymer blended with or chemically bound to the glassy SIC polymer; and/or (iii) optionally one or more nanoparticles dispersed in or chemically bound to at least one of the glassy SIC polymer and/or the flexible ion-conducting polymer. Electrolytes and devices containing the above compositions are also disclosed.

IPC Classes  ?

  • H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
  • H01M 10/058 - Construction or manufacture
  • H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

20.

VARIABLE STIFFNESS TREADMILL

      
Application Number US2024047611
Publication Number 2025/064758
Status In Force
Filing Date 2024-09-20
Publication Date 2025-03-27
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Artemiadis, Panagiotis
  • Thè, Zachary
  • Hobbs, Bradley
  • Chambers, Vaughn
  • Gaither, William

Abstract

A variable stiffness treadmill system is disclosed. An elevated split-belt treadmill has a left treadmill platform assembly and a right treadmill platform assembly, each includes a frame, a belt, and a motor for independently driving the respective belt. A variable stiffness mechanism (VSM) is operatively connected to the treadmill platform assembly and adjusts vertical stiffness of each belt. The VSM has at least one linear actuator adjustable for varying the vertical stiffness of each belt. A counterweight system is operatively connected to each treadmill platform assembly to counterbalance the weight of the treadmill platform assembly acting on the VSM in an unloaded configuration of the treadmill platform. The counterweight system has a pulley system driven by a roller chain and connected to opposite ends of each platform assembly. A plurality of guide rail bearings is operatively connected to the split-belt treadmill for constraining the split-belt treadmill to linear vertical deflection.

IPC Classes  ?

  • A63B 22/02 - Exercising apparatus specially adapted for conditioning the cardio-vascular system, for training agility or co-ordination of movements with movable endless bands
  • A63B 71/00 - Games or sports accessories not covered in groups

21.

NEO ACIDS AND DERIVATIVES THEREOF

      
Application Number 18718861
Status Pending
Filing Date 2022-12-16
First Publication Date 2025-02-27
Owner University of Delaware (USA)
Inventor
  • Sadula, Sunitha
  • Andini, Erha
  • Vlachos, Dionisios G.

Abstract

The invention provides neo acids (NAs) and derivatives thereof. Also provided is a method for producing a NA, comprising hydrodeoxygenation (HDO) of a furan-containing neo acid (FNA) in the presence a metal triflate and a hydrogenation catalyst. The NA production method may further comprise hydroxyalkylation/alkylation (HAA) of 2-alkylfuran with levulinic acid or pyruvic acid in the presence of an acid catalyst, and at least one of 2-alkylfuran, levulinic acid and pyruvic acid may be from a renewable carbon source. The NA may have a bio-based content in the range of 20-100% according to, for example, ASTM-D6866. Further provided are methods for producing branched alkanes (BAs), tertrahydrofuran-containing neo acid (THFNA) and furan-containing neo ester (FNE) and side products such as iso acids (IAs).

IPC Classes  ?

  • C07D 307/54 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07C 9/16 - Branched-chain hydrocarbons
  • C07C 9/22 - Acyclic saturated hydrocarbons with more than fifteen carbon atoms
  • C07C 53/126 - Acids containing more than four carbon atoms
  • C07D 307/16 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

22.

OPTICAL ATOMIC TELECOMMUNICATIONS-BAND CLOCK

      
Application Number US2024042319
Publication Number 2025/038753
Status In Force
Filing Date 2024-08-14
Publication Date 2025-02-20
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • UNIVERSITY OF DELAWARE (USA)
Inventor
  • Eustice, Scott Ethan
  • Stamper-Kurn, Dan
  • Novoa, Diego Tomas Dyer
  • Schrott, Jackson Stone
  • Safronova, Marianna Svyatoslavna
  • Filin, Dmytro
  • Porsev, Sergey Germanovich
  • Cheung, Charles

Abstract

An optical clock including a magneto optical trap configured to cool Titanium atoms using a first set of laser beams, an optical trap configured to trap the cooled Titanium atoms in a vacuum chamber using a second set of laser beams, and a clock laser. Each laser beam of the first set of laser beam has a respective cooling wavelength correspond to a first state transition between an excited state and a first state. Each laser beam of the second set of laser beams has a respective magic trapping wavelength. The clock laser emits a clock laser beam having a clock wavelength to cause trapped Titanium atoms in the first state to transition to a second state. The clock wavelength correspond to a second state transition between the first state and the second state. The clock wavelength is in the telecom band.

IPC Classes  ?

  • G04F 5/14 - Apparatus for producing preselected time intervals for use as timing standards using atomic clocks
  • H03L 7/26 - Automatic control of frequency or phaseSynchronisation using energy levels of molecules, atoms, or subatomic particles as a frequency reference

23.

DEVICE AND METHOD FOR MAKING SHEAR-ALIGNED, SOLVENT-CAST FILMS

      
Application Number 18720851
Status Pending
Filing Date 2022-12-16
First Publication Date 2025-02-13
Owner University of Delaware (USA)
Inventor
  • Gottlieb, Eric R.
  • Epps, Thomas H.

Abstract

Disclosed herein is an inline rolling shear alignment (IRSA) coating device and methods of producing a nanostructured film and inorganic nanostructures. The IRSA coating device comprises a coating head for disposing a solvent-containing film having a starting amount of solvent on a substrate; a roller comprising a rigid axle having a pad radially disposed thereon, the pad in contact with the film at a film-roller contact area located a distance from the deposition area; means for causing relative motion between the film and the roller in an operation direction at a film velocity; and a resistance member coupled to the roller, the resistance member configured to apply a rotation-opposing bias to the roller in an amount sufficient to cause the roller to apply a desired amount of shear stress to the film in the film-roller contact area during rotation of the roller.

IPC Classes  ?

  • C09D 153/02 - Vinyl aromatic monomers and conjugated dienes
  • B05D 3/12 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by mechanical means
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

24.

HIGH-RESOLUTION MAGNETIC IMAGING SYSTEM AND METHOD WITH DIAMOND MICROSTRUCTURES

      
Application Number US2024041704
Publication Number 2025/035090
Status In Force
Filing Date 2024-08-09
Publication Date 2025-02-13
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Ku, Mark
  • Asif, Shahidul
  • Chen, Hang

Abstract

A method for performing wide-field microscopy (WFM) using nitrogen vacancy (NV) centers in diamond. A diamond micro chip (DMC) having a (111)-oriented NV ensemble is temporarily adhered to a polymer microstructure on a portion of a transparent substrate, positioned above a placement location on a sample, and the transparent substrate tilted until the DMC detaches from the polymer microstructure and lands in the vicinity of the placement location, and then optionally its position is fined tuned. An image of the sample is then procured using NV WFM through the DMC.

IPC Classes  ?

  • G01R 33/60 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance using electron paramagnetic resonance
  • G01N 21/64 - FluorescencePhosphorescence
  • G01Q 60/52 - Resonance
  • A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves

25.

LUNG REPLICA AND USES THEREOF

      
Application Number 18709078
Status Pending
Filing Date 2022-11-09
First Publication Date 2025-02-06
Owner University of Delaware (USA)
Inventor
  • Fromen, Catherine Ann
  • Woodward, Ian

Abstract

The invention provides a lung replica to approximate spatial deposition in the human airway during breath. The lung replica comprises an upper airway compartment comprising an upper airway space: one or more lobe compartments, comprising two or more generation regions, a compressible terminal unit, and lattices in the two or more generation regions, and each comprising a lobar airway space connected with the upper airway space; and one or more modular components. The one or more modular components actuate the one or more lobe compartments to compress or expand. An exhaled airflow is generated when the one or more lobe compartments are compressed while an inhaled airflow is generated when the one or more lobe compartments are expanded. Also provided is a method for exchanging airflow in the lung replica. Further provided is a method for preparing a lobe compartment or a lung replica.

IPC Classes  ?

  • A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

26.

BIO-INSECTICIDES FROM WASTE BIOMASS

      
Application Number US2024037794
Publication Number 2025/015272
Status In Force
Filing Date 2024-07-12
Publication Date 2025-01-16
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Goculdas, Tejas
  • Sadula, Sunitha
  • Vlachos, Dionisios, G.

Abstract

Disclosed herein are bio-based insecticide compositions for more sustainable pest management practices that contain carbamate compounds. Processes for producing these bio-based insecticide compositions are also disclosed.

IPC Classes  ?

  • A01N 37/18 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N, e.g. carboxylic acid amides or imidesThio-analogues thereof
  • A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
  • A01N 25/30 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants

27.

SYSTEMS AND METHODS FOR RECYCLING END-OF-USE TEXTILES INTO SECOND GENERATION TEXTILES

      
Application Number 18765772
Status Pending
Filing Date 2024-07-08
First Publication Date 2025-01-09
Owner University of Delaware (USA)
Inventor
  • Cao, Huantian
  • Cobb, Kelly
  • Shen, Hongqing

Abstract

A process for making a textile from a feedstock comprising a quantity of post-consumer apparel, each item of apparel having a desired textile composition and devoid of non-textile materials, including shredding the feedstock to obtain textile shreds, providing the textile shreds as a component in at least a first layer of a plurality of stacked layers comprising at least a second layer of supporting material, and feeding the plurality of stacked layers through a needle-felting machine in a plurality of passes, including at least one pass in each of a plurality of different 90-degree offset orientations. The textile shreds, or a mixture of the textile shreds and new textile fibers comprising no more than 15%-20% new textile fibers, may be carded with a carding machine to form a batting. Products made by the process may include a 100% cotton mulch mat for agricultural use.

IPC Classes  ?

  • A01G 13/02 - Protective coverings for plants; Devices for laying-out coverings
  • C09K 17/52 - Mulches

28.

OXIDATIVE DEHYDROGENATION OF ETHANE OVER BORON-CONTAINING CHABAZITE

      
Application Number US2024034976
Publication Number 2024/263887
Status In Force
Filing Date 2024-06-21
Publication Date 2024-12-26
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Lobo, Raul, F.
  • Huang, Xinlei
  • Kuo, Mi, Jen

Abstract

Disclosed herein are processes of oxidative dehydrogenation of ethane to ethylene that involve the use of boron-containing chabazite. Systems for performing the processes are also disclosed.

IPC Classes  ?

  • C07C 2/02 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons
  • C07C 2/06 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation of alkenes, i.e. acyclic hydrocarbons having only one carbon-to-carbon double bond
  • C07C 2/08 - Catalytic processes
  • C07C 2/10 - Catalytic processes with metal oxides
  • C07C 5/42 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with a hydrogen acceptor

29.

TRANS-CYCLOOCTENE COMPOUNDS AND METHODS OF USE IN THE SYNTHESIS OF PET PROBES AND RADIOISOTOPE BASED THERAPY

      
Application Number US2024035275
Publication Number 2024/264053
Status In Force
Filing Date 2024-06-24
Publication Date 2024-12-26
Owner
  • THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
  • UNIVERSITY OF DELAWARE (USA)
Inventor
  • Li, Zibo
  • Fox, Joseph, Michael
  • Pigga, Jessica
  • Wu, Zhanhong
  • Xu, Muyun
  • Ma, Xinrui
  • Zhang, He

Abstract

This invention relates to the development of bioorthogonal reactant compounds, e.g., 5-hydroxy strained trans-cyclooctene compounds, and to methods of synthesizing said compounds. Moreover, this invention relates to methods of synthesizing positron emission tomography (PET) imaging probes using the bioorthogonal reactant compounds as described herein, as well as probes produced by the methods. Lastly, this invention relates to methods of detecting a tumor in a subject by administering said bioorthogonal reactant compounds and/or PET probes that are described herein.

IPC Classes  ?

  • A61K 31/13 - Amines, e.g. amantadine
  • A61K 31/31 - Mercury compounds containing nitrogen
  • A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
  • A61K 31/275 - NitrilesIsonitriles

30.

DIRECT HYDROGEN CYANIDE SYNTHESIS VIA PLASMA-ASSISTED CONVERSION OF METHANE AND NITROGEN

      
Application Number US2024032740
Publication Number 2024/254261
Status In Force
Filing Date 2024-06-06
Publication Date 2024-12-12
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Kamarinopoulou, Nefeli
  • Vlachos, Dionisios G.

Abstract

Disclosed herein are processes that can directly synthesize hydrogen cyanide from methane and nitrogen in a single-step conversion. Systems for performing the process are also disclosed.

IPC Classes  ?

  • C01C 3/02 - Preparation of hydrogen cyanide
  • C01B 3/34 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents

31.

FUNCTIONALIZED THIOPHENE POLYMER--BASED BIOSENSORS

      
Application Number US2024027686
Publication Number 2024/229358
Status In Force
Filing Date 2024-05-03
Publication Date 2024-11-07
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Martin, David
  • Wu, Yuhang
  • Lee, Junghyun

Abstract

The present invention provides a biosensor for detecting an analyte. The biosensor comprises an electrode having a surface coated with a layer of a biological molecule-immobilized functionalized thiophene polymer, which comprises a biological molecule and a functionalized thiophene polymer. The biological molecule is immobilized to the functionalized thiophene polymer via covalent binding and is capable of forming a complex with the analyte. Also provided are a method for preparing the biosensor and a method for detecting an analyte with the biosensor.

IPC Classes  ?

  • G01N 27/327 - Biochemical electrodes
  • H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances
  • C07D 495/04 - Ortho-condensed systems
  • C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule

32.

COAXIAL DIELECTRIC BARRIER DISCHARGE PLASMA BIPHASIC MICROREACTOR FOR CONTINUOUS OXIDATIVE PROCESSES

      
Application Number 18685604
Status Pending
Filing Date 2022-08-23
First Publication Date 2024-10-24
Owner University of Delaware (USA)
Inventor
  • Dimitrakellis, Panagiotis
  • Cameli, Fabio
  • Vlachos, Dionisios G.

Abstract

A reactor assembly for igniting and sustaining a plasma and method for performing a reaction. The assembly includes an elongated cylindrical inner electrode; a dielectric tube arranged helically around the elongated cylindrical inner electrode to form a helical reactor. The reactor assembly also includes an annular outer electrode arranged around at least a portion of the exterior of the helical reactor. The assembly includes a power source to provide a voltage across the elongated cylindrical inner electrode and the annular outer electrode. A process stream including at least a gas flows through the dielectric tube. The voltage is applied across the elongated cylindrical inner electrode and the annular outer electrode such that at least a portion of the flow of the process stream through the dielectric tube is exposed to the voltage and the plasma is ignited and sustained.

IPC Classes  ?

  • B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
  • C01B 3/34 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents
  • C01B 15/027 - Preparation from water
  • C02F 1/72 - Treatment of water, waste water, or sewage by oxidation
  • C02F 101/30 - Organic compounds
  • C07B 33/00 - Oxidation in general

33.

METHODS FOR CURTAILING BIOGENIC METHANE EMISSIONS USING PYROGENIC CARBON

      
Application Number US2024022050
Publication Number 2024/206682
Status In Force
Filing Date 2024-03-28
Publication Date 2024-10-03
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Chiu, Pei
  • Xin, Danhui

Abstract

A method for reducing methane emitted from an anaerobic ecosystem comprising a microbial source prone to methanogenesis. The method comprising adding a quantity of pyrogenic carbon (PC), such as biochar (BC), as a terminal electron acceptor to promote anaerobic respiration and suppress methanogenesis. In one embodiment, the biochar is added in at least a quantity corresponding to a ratio of unit weight PC for each mmol of methane otherwise expected to be produced and desired to be reduced from the anaerobic ecosystem, wherein the ratio equals A*0.125*ESC*M per mol methane reduction, wherein: A = ESC bioavailability factor; ESC = electrons accepted in mol/unit weight; and M = unit weight of PC or BC.

IPC Classes  ?

  • A01B 79/00 - Methods for working soil
  • B09C 1/10 - Reclamation of contaminated soil microbiologically or by using enzymes
  • C02F 3/28 - Anaerobic digestion processes

34.

SYSTEMS FOR REAL-TIME PREDICTION OF TRANSITIONS TO RIGID AND COMPLIANT SURFACES USING MYOELECTRIC AND KINEMATIC DATA

      
Application Number US2024021108
Publication Number 2024/197237
Status In Force
Filing Date 2024-03-22
Publication Date 2024-09-26
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Artemiadis, Panagiotis
  • Angelidou, Charikleia

Abstract

An electronic control system of a lower limb prosthesis includes a control device, a plurality of sensors, and a controller. The plurality of sensors captures kinematic data and electromyographic (EMG) recordings during at least one gait cycle. The gait cycle has at least one of: a rigid (R) terrain scenario corresponding to movement between a rigid surface and another rigid surface, and a transition (T) terrain scenario corresponding to movement between the rigid surface and a compliant surface. The controller processes the kinematic data and EMG recordings, then performs a classification thereof as corresponding to the R terrain or T terrain scenario, and predicts a subject's intent to move in accordance with the R terrain or T terrain scenario. The controller is configured to dynamically modify, in real-time, one or more control settings of the control device in response to the classification of the kinematic data and EMG recordings.

IPC Classes  ?

  • A61F 2/72 - Bioelectric control, e.g. myoelectric
  • A61F 2/64 - Knee joints
  • A61F 2/66 - FeetAnkle joints
  • A61F 2/76 - Means for assembling, fitting, or testing prostheses, e.g. for measuring or balancing
  • A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

35.

HIGH ANKLE BRACE

      
Application Number 18275069
Status Pending
Filing Date 2022-02-02
First Publication Date 2024-09-26
Owner University of Delaware (USA)
Inventor
  • Hall, Martha
  • Desantis, Brandon
  • Bink, Kiki
  • Curtin, Riley
  • Reynolds, Andrew
  • Swamy, Rachel
  • Yoo, Jaeah
  • Ashrafi, Marjan

Abstract

An ankle brace configured to be worn by a target wearer having a foot, an ankle, a lower leg, and a tibia and a fibula disposed within the lower leg, is disclosed. The ankle brace comprises a foot plate having a foot bed contoured to underlie the foot. The foot bed has a heel cup extending upward from the foot bed and has a relatively greater flexibility than a front foot portion of the foot bed. An orthopedic splint is pivotably coupled to the foot plate and configured to at least partially wrap around the lower leg. The orthopedic splint is disposed in an adjustable pocket, which is configured to adjust compression of the orthopedic splint relative to the lower leg to promote a rehabilitative position of the tibia and the fibula. The foot plate may be fabricated with a computer aided manufacturing process.

IPC Classes  ?

  • A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

36.

PRODUCTION OF LIGNIN DERIVED RENEWABLE LUBRICANTS

      
Application Number 18681356
Status Pending
Filing Date 2022-08-08
First Publication Date 2024-09-19
Owner University of Delaware (USA)
Inventor
  • Ebikade, Elvis Osamudiamhen
  • Sadula, Sunitha
  • Liu, Sibao
  • Vlachos, Dionisios G.

Abstract

Disclosed herein are bio-based compositions comprising branched aromatic compounds and/or branched cycloaliphatic compounds, and methods of their preparation from lignin-derived monomers, and their use as base oils in lubricant compositions, personal care compositions, and pharmaceutical compositions.

IPC Classes  ?

  • C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
  • A61K 8/31 - Hydrocarbons
  • A61K 8/33 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K 8/34 - Alcohols
  • A61K 47/06 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
  • A61K 47/08 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen
  • A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
  • A61Q 19/00 - Preparations for care of the skin
  • C07C 13/28 - Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
  • C07C 41/30 - Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation

37.

DUAL CURE ADDITIVE MANUFACTURING

      
Application Number US2024020110
Publication Number 2024/192332
Status In Force
Filing Date 2024-03-15
Publication Date 2024-09-19
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Fu, Kun
  • Deng, Kaiyue
  • Zhang, Chunyan

Abstract

A method for manufacturing a composite material includes providing a matrix comprising a fiber material and a thermoset polymer. A length of the fiber tow is impregnated with the thermoset polymer via a Localized-In-Plane Thermal Assist (LITA) impregnation system. A dual curable polymer is provided between a first layer of the matrix and the second layer of the matrix, and the dual curable polymer includes a thermally curable component and a photocurable component curable by exposure to actinic radiation. The dual curable polymer is exposed to actinic radiation to at least partially cure the photocurable component. In this way, a layer of the composite material is formed, and the aforementioned steps are repeated until a desired number of layers have been stacked together to create a structure. The layer or the structure is heated to thermally cure the thermoset polymer and the thermally curable component of the dual curable polymer.

IPC Classes  ?

  • B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
  • B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
  • B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
  • B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
  • B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
  • B29C 64/00 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
  • B29C 64/10 - Processes of additive manufacturing

38.

ALIPHATIC ANION EXCHANGE POLYMERS

      
Application Number 18435852
Status Pending
Filing Date 2024-02-07
First Publication Date 2024-08-22
Owner
  • University of Delaware (USA)
  • Versogen, Inc. (USA)
Inventor
  • Yan, Yushan
  • Wang, Junhua
  • Duan, Hui
  • Hu, Keda
  • Wang, Lan
  • Shi, Wenjuan

Abstract

Alkaline-stable cations were introduced to a polyolefin bearing phenyl side chains to enable manipulation of ion exchange capacity and hot pressing technique. Hydroxide exchange membranes or hydroxide exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved device stability as compared to conventional hydroxide exchange membranes or ionomers. Hydroxide exchange membrane fuel cells and hydroxide exchange membrane electrolyzers comprising the polyolefin with pendant cation provide enhanced performance and durability at relatively high temperatures.

IPC Classes  ?

  • B01J 41/14 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
  • H01M 8/1004 - Fuel cells with solid electrolytes characterised by membrane-electrode assemblies [MEA]
  • H01M 8/103 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having nitrogen, e.g. sulfonated polybenzimidazoles [S-PBI], polybenzimidazoles with phosphoric acid, sulfonated polyamides [S-PA] or sulfonated polyphosphazenes [S-PPh]
  • H01M 8/1081 - Polymeric electrolyte materials characterised by the manufacturing processes starting from solutions, dispersions or slurries exclusively of polymers
  • H01M 8/1086 - After-treatment of the membrane other than by polymerisation

39.

ALIPHATIC ANION EXCHANGE POLYMERS

      
Application Number US2024014857
Publication Number 2024/168074
Status In Force
Filing Date 2024-02-07
Publication Date 2024-08-15
Owner
  • UNIVERSITY OF DELAWARE (USA)
  • VERSOGEN, INC. (USA)
Inventor
  • Wang, Junhua
  • Hu, Keda
  • Wang, Lan
  • Yan, Yushan
  • Duan, Hui
  • Shi, Wenjuan

Abstract

Alkaline-stable cations were introduced to a polyolefin bearing phenyl side chains to enable manipulation of ion exchange capacity and hot pressing technique. Hydroxide exchange membranes or hydroxide exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved device stability as compared to conventional hydroxide exchange membranes or ionomers. Hydroxide exchange membrane fuel cells and hydroxide exchange membrane electrolyzers comprising the polyolefin with pendant cation provide enhanced performance and durability at relatively high temperatures.

IPC Classes  ?

  • C07C 211/63 - Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
  • B01J 41/09 - Organic material
  • C08F 212/14 - Monomers containing only one unsaturated aliphatic radical containing one ring substituted by hetero atoms or groups containing hetero atoms
  • C08L 23/08 - Copolymers of ethene

40.

ELECTROCHEMICAL GENERATION OF CARBON-CONTAINING PRODUCTS FROM CARBON DIOXIDE AND CARBON MONOXIDE

      
Application Number 18594354
Status Pending
Filing Date 2024-03-04
First Publication Date 2024-08-01
Owner University of Delaware (USA)
Inventor
  • Jiao, Feng
  • Jouny, Matthew
  • Lv, Jing-Jing

Abstract

Disclosed herein is a method of electroreduction with a working electrode and counter electrode. The method includes a step of electrocatalyzing carbon monoxide and/or carbon dioxide in the presence of one or more nucleophilic co-reactants in contact with a catalytically active material present on the working electrode, thereby forming one or more carbon-containing products electrocatalytically.

IPC Classes  ?

  • C25B 3/26 - Reduction of carbon dioxide
  • C25B 1/23 - Carbon monoxide or syngas
  • C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms

41.

SUPER-SEMICONDUCTORS BASED ON NANOSTRUCTURED ARRAYS

      
Application Number US2023021885
Publication Number 2024/151282
Status In Force
Filing Date 2023-05-11
Publication Date 2024-07-18
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Wei, Bingqing
  • Li, Zhigang

Abstract

A super-semiconductor (SSC), semiconductor devices including the SSC, and methods for making the SSC. The SSC includes a bimetallic nanostructured array having a substrate and a nanoshell array disposed on the substrate. The nanoshell array is defined by a plurality of non-close-packed, non-conductive, core bodies disposed on the substrate, a first metal layer disposed on the non-conductive core bodies and on the substrate in areas located between adjacent non-conductive core- bodies, and at least a second metal layer disposed on the first metal layer, wherein the second metal is different than the first metal. The bimetallic nanostructured array exhibits p-type or n-type metal conductivity above a transition temperature, and in embodiments, exhibits resistivity in a range of 10-8- 10-7 ohm*m at a temperature of 300K +/- 40K.

IPC Classes  ?

  • H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
  • H01L 27/02 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier
  • H01L 27/10 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including a plurality of individual components in a repetitive configuration
  • B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
  • H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
  • H01L 21/8256 - Manufacture or treatment of devices consisting of a plurality of solid state components or integrated circuits formed in, or on, a common substrate with subsequent division of the substrate into plural individual devices to produce devices, e.g. integrated circuits, each consisting of a plurality of components the substrate being a semiconductor, using technologies not covered by one of groups , or
  • H01L 23/29 - Encapsulation, e.g. encapsulating layers, coatings characterised by the material
  • H01L 29/66 - Types of semiconductor device
  • B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

42.

BIO-BASED POLYMERS FOR THE PURIFICATION OF HIGH COMMERCIAL VALUE CHEMICALS EXTRACTED FROM PLANTS, FOOD WASTE, AND NON-FOOD BIOMASS

      
Application Number 18490069
Status Pending
Filing Date 2023-10-19
First Publication Date 2024-07-11
Owner University of Delaware (USA)
Inventor
  • Gupta, Yagya
  • Beckett, Laura E.
  • Sadula, Sunitha
  • Vlachos, Dionisios G.
  • Korley, Lashanda T.

Abstract

Disclosed herein is a process for separating phenolic acids, comprising a step a) of contacting a feed containing at least two different phenolic acids (PA) with an extraction solvent to extract the at least two different PAs in a first PA containing liquid. The process also comprises a step b) of contacting the first PA containing liquid with a solid molecular imprinted polymer (MIP), such that the MIP captures a target PA from the at least two different PAs, to thereby form a first PA bound MIP dispersed in a second PA containing liquid, where the second PA containing liquid comprises at least one PA and none or a substantially lesser amount of the target PA originally present in the first PA containing liquid. The process further comprises a step c) of separating the first phenolic acid bound MIP from the second PA containing liquid, and a step d) of separating the target phenolic acid from the first PA bound MIP to obtain a recovered MIP, wherein the recovered MIP is substantially free of the target phenolic acid.

IPC Classes  ?

  • C07C 67/58 - SeparationPurificationStabilisationUse of additives by liquid-liquid treatment
  • C08J 11/08 - Recovery or working-up of waste materials of polymers without chemical reactions using selective solvents for polymer components

43.

ANKLE FOOT ORTHOSIS

      
Application Number 18275063
Status Pending
Filing Date 2022-02-11
First Publication Date 2024-07-11
Owner University of Delaware (USA)
Inventor
  • Hall, Martha
  • Arch, Elisa Sarah
  • Neti, Ahlad
  • Khandha, Ashutosh D.

Abstract

An ankle-foot orthosis having a foot plate defining a foot bed contoured to underlie the foot of the wearer, a flexible cuff configured to wrap around at least a portion of the shank of the wearer, and a strut assembly comprising a plurality of metal wires connecting the foot plate to the cuff. The plurality of metal wires may include piano wires. The foot plate may be fabricated with a computer aided manufacturing process.

IPC Classes  ?

  • A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

44.

METHOD AND SYSTEM FOR DYNAMIC CAPILLARY-DRIVEN ADDITIVE MANUFACTURING OF CONTINUOUS FIBER COMPOSITE

      
Application Number 18428961
Status Pending
Filing Date 2024-01-31
First Publication Date 2024-07-04
Owner University of Delaware (USA)
Inventor
  • Fu, Kelvin
  • Shi, Baohui

Abstract

A process for additive manufacturing of a thermoset resin fiber reinforced composite, composites produced using the same, and system for producing such a composite. The process includes depositing a fiber material along a path having a direction; heating the fiber material using a heater to generate a moving thermal gradient in the fiber material trailing the heater relative to the path direction; and dispensing a thermosetting polymer material on the heated fiber material at a trailing distance the from the heater along the path. The thermosetting polymer dynamically wicks into the fiber material along the thermal gradient in the path direction.

IPC Classes  ?

  • B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
  • B29C 64/321 - Feeding
  • B29K 63/00 - Use of epoxy resins as moulding material
  • B29K 307/04 - Carbon
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
  • B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials

45.

LIGNIN-DERIVED AND PERFORMANCE-ENHANCED NON-ISOCYANATE POLYURETHANE THERMOSETS

      
Application Number 18540190
Status Pending
Filing Date 2023-12-14
First Publication Date 2024-07-04
Owner University of Delaware (USA)
Inventor
  • Mhatre, Sampanna V.
  • Mahajan, Jignesh S.
  • Epps,, Iii, Thomas H.
  • Korley, Lashanda T. J.

Abstract

Disclosed herein are bio-derivable polyhydroxyurethanes, methods of making them, compositions comprising the same, and articles comprising such compositions. The bio-derivable polyhydroxyurethane comprises in polymerized form at least one polymerizable lignin-derivable cyclic carbonate monomer, and one or more polymerizable amine crosslinkers, each comprising two or more primary amines, such that at least one of the one or more polymerizable amine crosslinkers comprises three primary amines. The bio-derivable polyhydroxyurethanes display enhanced mechanical performance as compared to the petroleum-derived analogues.

IPC Classes  ?

46.

NANOPARTICLES AND BIOTEMPLATES WITH TUNABLE LENGTH AND METHODS OF MANUFACTURING THE SAME

      
Application Number 18516243
Status Pending
Filing Date 2023-11-21
First Publication Date 2024-06-27
Owner
  • Purdue Research Foundation (USA)
  • University of Delaware (USA)
Inventor
  • Solomon, Kevin
  • Lee, Kok Zhi
  • Vaidya, Akash
  • Rammohan, Mruthula

Abstract

Methods and nucleic acid sequences for the synthesis of biotemplates in a non-plant based expression system are provided. Such biotemplates include Barley stripe mosaic virus viral-like particles (BSMV-VLPs) that are capable of self-assembly due to being operatively linked with an origin of self-assembly with the Barley stripe mosaic virus capsid protein (BSMV-CP). Also provided are BSMV-VLPs that are capable of self-assembly due one or more site-directed mutations on the BSMV-CP, and BSMV-VLPs that exhibit enhanced stability due to such site-directed mutation(s).

IPC Classes  ?

  • C12N 15/70 - Vectors or expression systems specially adapted for E. coli
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
  • C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
  • C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

47.

Catalytic hydroconversion of polypropylene-based plastic waste to lubricant base-oils

      
Application Number 18281349
Grant Number 12403455
Status In Force
Filing Date 2022-03-10
First Publication Date 2024-05-23
Grant Date 2025-09-02
Owner University of Delaware (USA)
Inventor
  • Vlachos, Dionisios G.
  • Liu, Sibao
  • Vance, Brandon
  • Wang, Cong
  • Kots, Pavel

Abstract

n].

IPC Classes  ?

  • B01J 23/46 - Ruthenium, rhodium, osmium or iridium
  • B01J 21/06 - Silicon, titanium, zirconium or hafniumOxides or hydroxides thereof
  • B01J 21/08 - Silica
  • B01J 21/18 - Carbon
  • B01J 23/10 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of rare earths
  • B01J 23/75 - Cobalt
  • B01J 23/755 - Nickel
  • B01J 23/94 - Regeneration or reactivation of catalysts comprising metals, oxides or hydroxides of the iron group metals or copper
  • B01J 23/96 - Regeneration or reactivation of catalysts comprising metals, oxides or hydroxides of the noble metals
  • B01J 37/02 - Impregnation, coating or precipitation
  • B01J 37/18 - Reducing with gases containing free hydrogen
  • B01J 38/02 - Heat treatment
  • B01J 38/10 - Gas or vapour treatingTreating by using liquids vaporisable upon contacting spent catalyst using elemental hydrogen
  • C10G 1/06 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal by destructive hydrogenation
  • C10G 1/10 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal from rubber or rubber waste
  • C10M 105/04 - Well-defined hydrocarbons aliphatic
  • C10M 177/00 - Special methods of preparation of lubricating compositionsChemical modification by after-treatment of components or of the whole of a lubricating composition, not covered by other classes
  • C10N 70/00 - Special methods of preparation

48.

OXIDATION RESISTANT POLYMERS FOR USE AS ANION EXCHANGE MEMBRANES AND IONOMERS

      
Application Number 18276019
Status Pending
Filing Date 2022-02-04
First Publication Date 2024-04-25
Owner
  • University of Delaware (USA)
  • Versogen, Inc. (USA)
Inventor
  • Yan, Yushan
  • Hu, Keda
  • Wang, Lan
  • Setzler, Brian
  • Shi, Wenjuan
  • Wang, Junhua

Abstract

Hydroxide-exchange membranes (HEMs) and hydroxide-exchange ionomers (HEIs) are provided which include polymers with oxidation resistant groups. The attachment of the oxidation resistant groups to the polymer backbone allows fine-tuning of the mechanical properties of the membrane and incorporation of alkaline stable cations, such as imidazoliums, phosphoniums and ammoniums, and provides enhanced stability to the polymer. HEMs/HEIs formed from these polymers exhibit superior chemical stability, anion conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional HEM/HEIs. The HEMs exhibit enhanced stability in a highly oxidative environment.

IPC Classes  ?

49.

SYSTEM AND APPARATUS FOR MEASURING SCATTERED LIGHT SIGNALS FROM PRESSURIZED SOLUTIONS AND METHOD OF ASSEMBLY

      
Application Number US2023029655
Publication Number 2024/030679
Status In Force
Filing Date 2023-08-07
Publication Date 2024-02-08
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Berger, Jordan, Evan
  • Roberts, Christopher, J.
  • Qi, Wei
  • Marujo Teixeira, Susana
  • Sloey, Christopher

Abstract

A system for evaluating light scattering properties of a liquid sample includes a light scattering instrument with a chassis and a laser source that emits a laser beam along a path. An apparatus includes a pressure cell with a chamber for containing a fluid pressurized up to 350 MPa and a plurality of light-transmissive windows, including a beam entry window and a beam exit window positioned in the path of the laser beam, and one or more windows positioned orthogonal to the path of the laser beam. A biological sample is received in the pressure cell. A plurality of detectors includes a transmission detector disposed adjacent the beam exit window, or light scattering detectors positioned adjacent the windows orthogonal to the path of the laser beam and configured to detect light scattered from the laser beam passing through the sample. An external condition-inducing system provides a fluid temperature and pressure.

IPC Classes  ?

  • G01N 21/51 - Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
  • G01N 21/03 - Cuvette constructions
  • G01N 21/65 - Raman scattering

50.

MICROWAVE-ASSISTED CATALYTIC PYROLYSIS PROCESS AND REACTOR FOR SELECTIVELY CONVERTING PLASTIC TO ALKENES

      
Application Number US2023027762
Publication Number 2024/015567
Status In Force
Filing Date 2023-07-14
Publication Date 2024-01-18
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Selvam, Esun
  • Kots, Pavel
  • Chen, Weiqi
  • Vlachos, Dionisios, G.

Abstract

The present disclosure provides a pyrolysis process for converting a plastic comprising a polyolefin polymer to an alkene. The process comprises contacting the plastic with a catalyst in a one-pot pyrolysis system at a temperature between about 350 °C and about 500 °C; wherein the catalyst comprises a solid acid. The present disclosure further provides a one-pot pyrolysis system and uses of a solid acid in the pyrolysis process for converting plastic comprising a polyolefin polymer to an alkene.

IPC Classes  ?

  • B01J 6/00 - CalciningFusing
  • B09B 3/40 - Destroying solid waste or transforming solid waste into something useful or harmless involving thermal treatment, e.g. evaporation
  • C10B 53/07 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form of synthetic polymeric materials, e.g. tyres
  • B01J 19/24 - Stationary reactors without moving elements inside

51.

FOAM VACCINATION OF AVIANS

      
Application Number 18350357
Status Pending
Filing Date 2023-07-11
First Publication Date 2024-01-11
Owner University of Delaware (USA)
Inventor
  • Li, Hong
  • Elliott, Kenneth C.

Abstract

The invention provides a method for vaccinating one or more avians in need thereof. The vaccination method comprises administering to the one or more avians a stable foam in an amount effective for inducing a neutralizing immune response against an infectious pathogen in the one or more avians. The foam comprises a gas and a liquid, and the liquid comprises a vaccine and a foaming agent. The avian may be a chick. Also provided is a method for preparing the stable foam.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
  • A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
  • A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
  • A61P 31/14 - Antivirals for RNA viruses

52.

CELLULAR MEMBRANE VESICLES AND USES THEREOF

      
Application Number 18032094
Status Pending
Filing Date 2021-10-14
First Publication Date 2023-12-07
Owner University of Delaware (USA)
Inventor
  • Papoutsakis, Eleftherios
  • Das, Samik

Abstract

The present invention provides a stable non-naturally occurring cellular membrane vesicle for delivering an active agent into a target cell. The cellular membrane vesicle comprises a biological membrane from a parent cell and a liquid medium encapsulated by the biological membrane. The liquid medium comprises an active agent and does not comprise a native cytoplasmic component of the parent cell. The biological membrane is specific for the target cell, and the active agent remains active upon delivery into the target cell. Also provided are methods for delivering the active agent with the cellular membrane vesicle and methods of preparing the cellular membrane vesicles.

IPC Classes  ?

  • A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
  • C12N 9/22 - Ribonucleases

53.

Electrochemical devices and fuel cell systems

      
Application Number 18234278
Grant Number 12334611
Status In Force
Filing Date 2023-08-15
First Publication Date 2023-12-07
Grant Date 2025-06-17
Owner University of Delaware (USA)
Inventor
  • Yan, Yushan
  • Setzler, Brian

Abstract

Electrochemical devices including electrochemical pumps (ECPs) and fuel cell systems comprising a fuel cell and an ECP are disclosed. In particular, this electrochemical device can be an ECP that comprises an anode, a cathode and an anion exchange polymer separating the anode from the cathode. The ECP can be coupled to a hydroxide exchange membrane fuel cell (HEMFC) that is disclosed herein as a fuel cell system. These devices can be used in methods for removing carbon dioxide from air and for generating electricity.

IPC Classes  ?

  • H01M 8/0612 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants from carbon-containing material
  • B01D 53/32 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
  • H01M 4/90 - Selection of catalytic material
  • H01M 4/92 - Metals of platinum group
  • H01M 8/0258 - CollectorsSeparators, e.g. bipolar separatorsInterconnectors characterised by the configuration of channels, e.g. by the flow field of the reactant or coolant
  • H01M 8/0656 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants by electrochemical means
  • H01M 8/0662 - Treatment of gaseous reactants or gaseous residues, e.g. cleaning
  • H01M 8/10 - Fuel cells with solid electrolytes
  • H01M 8/1018 - Polymeric electrolyte materials

54.

MEDIUM AND DEVICE FOR PROTEOMIC SAMPLE PREPARATION

      
Application Number US2023020215
Publication Number 2023/212205
Status In Force
Filing Date 2023-04-27
Publication Date 2023-11-02
Owner UNIVERSITY OF DELAWARE (USA)
Inventor Yu, Yanbao

Abstract

The invention provides a medium. The medium comprises a fibrous matrix and silica microparticles immobilized in the fibrous matrix. The fibrous matrix may comprise glass fibers, polyolefin fibers, polyvinylidene fluoride (PVDF) fibers, polytetrafluoroethylene (PTFE) fibers, polypropylene fibers, polyethylene fibers, aramid fibers, natural cellulosic fibers, or a combination thereof. A composition comprising the medium is provided. A device comprising the medium or the composition is also provided. Further provided are methods for preparing a proteomic sample from a biological sample on the medium. The biological sample comprises cells or proteins. The method may comprise a treating step, a digesting step, a reducing and alkylating step, and an eluting step. All of these steps may be performed on the medium. The proteomic sample comprises the eluted peptides. The proteomic sample may be desalted. The peptides prepared from the biological sample may be suitable for qualitative or quantitative analysis, for example, mass spectrometric analysis.

IPC Classes  ?

  • B01D 39/06 - Inorganic material, e.g. asbestos fibres, glass beads or fibres
  • B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
  • B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires

55.

PROCESS AND SYSTEM FOR ADDITIVE MANUFACTURING OF CARBON SCAFFOLDS

      
Application Number US2023019227
Publication Number 2023/205309
Status In Force
Filing Date 2023-04-20
Publication Date 2023-10-26
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Fu, Kun
  • Zhang, Chunyan

Abstract

A process for additive manufacturing of a nanocomposite is disclosed. The process includes providing a uniform filament comprising a carbon fiber material and a polymer binder; dispensing the uniform filament to form a preform architecture that defines a first 3-dimensional bulk structure having a first set of volume-defining dimensions; heating the preform architecture to remove the polymer binder, thereby forming a porous carbon scaffold; and incorporating a matrix material into the porous carbon scaffold to form a third 3-dimensional bulk structure. The carbon scaffold defines a second 3-dimensional bulk structure having a second bulk volume, wherein the second bulk volume is equal to the first bulk volume within a tolerance of 10%. A system for additive manufacturing of a fiber reinforced composite is also disclosed. The system has a filament dispenser; means for moving the filament dispenser; a heater; and a matrix material applicator.

IPC Classes  ?

  • B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
  • B29C 67/20 - Shaping techniques not covered by groups , or for porous or cellular articles, e.g. of foam plastics, coarse-pored
  • B29C 71/02 - Thermal after-treatment

56.

TRANS-CYCLOOCTENES WITH HIGH REACTIVITY AND FAVORABLE PHYSIOCHEMICAL PROPERTIES

      
Application Number 18210862
Status Pending
Filing Date 2023-06-16
First Publication Date 2023-10-19
Owner University of Delaware (USA)
Inventor
  • Fox, Joseph M.
  • Pigga, Jessica
  • Boyd, Samantha Jo

Abstract

The present invention discloses a new class of trans-cyclooctenes (TCOs), “a-TCOs,” that are prepared in high yield via stereocontrolled 1,2-additions of nucleophiles to trans-cyclooct-4-enone, which itself was prepared on large scale in two steps from 1,5-cyclooctadiene. Computational transition state models rationalize the diastereoselectivity of 1,2-additions to deliver a-TCO products, which were also shown to be more reactive than standard TCOs and less hydrophobic than even a trans-oxocene analog. Illustrating the favorable physicochemical properties of a-TCOs, a fluorescent TAMRA derivative in live HeLa cells was shown to be cell-permeable through intracellular Diels-Alder chemistry and to washout more rapidly than other TCOs.

IPC Classes  ?

  • C07C 49/607 - Unsaturated compounds containing a keto group being part of a ring of a seven- to twelve-membered ring
  • C07C 35/20 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing seven- or eight-membered rings
  • C07C 35/21 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
  • C07D 311/82 - Xanthenes
  • C07D 207/408 - Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
  • C07C 29/143 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of ketones

57.

Hydrocracking catalysts and uses thereof

      
Application Number 18010917
Grant Number 12305126
Status In Force
Filing Date 2021-06-17
First Publication Date 2023-10-12
Grant Date 2025-05-20
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Liu, Sibao
  • Vlachos, Dionisios G.

Abstract

b)] and the moiety Z are mechanically mixed; wherein the weight percentage of the moiety Z is about 1% to about 99% of the total weight of the catalyst. Furthermore, the present disclosure provides a tunable, low-temperature, energy-efficient process for hydrocracking plastics to form a fuel, a lubricant, or a mixture thereof.

IPC Classes  ?

58.

Method to thermo-reversibly control light and heat flow with bicontinuous micro-domain

      
Application Number 18017106
Grant Number 12411336
Status In Force
Filing Date 2021-07-27
First Publication Date 2023-09-28
Grant Date 2025-09-09
Owner
  • University Of Delaware (USA)
  • Government of the United States of America, as Represented by the Secretary of Commerce (USA)
Inventor
  • Xi, Yuyin
  • Liu, Yun

Abstract

A dynamically tunable composition, a device including the composition, a method of dynamically tuning radiation transmission through the composition, and a method of thermo-reversibly controlling operation of a filter formed from the composition. The composition includes a plurality of nanoparticles dispersed in a single phase region of a binary solvent systems composed of a first solvent and a second solvent, the nanoparticles having a preferential wettability to the first solvent. Changing temperature of the composition causes it to transition thermo-reversibly from the liquid state to a gel state having bi-continuous domains, including a particle domain and a solvent domain. The particle domain features nanoparticles dispersed in a first-solvent-rich fraction of the binary solvent system, and the solvent domain is a second-solvent-rich fraction of the binary solvent system. Exemplary devices incorporating the composition include a filter, a temperature sensor, a smart window, a smart display, a battery, and a tissue growth scaffold.

IPC Classes  ?

  • G02B 26/00 - Optical devices or arrangements for the control of light using movable or deformable optical elements
  • C09K 9/00 - Tenebrescent materials, i.e. materials for which the range of wavelengths for energy absorption is changed as a result of excitation by some form of energy
  • B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals

59.

ENGINEERED EXTRACELLULAR VESICLES FOR TARGETED DRUG DELIVERY TO MUSCLE

      
Application Number US2023064840
Publication Number 2023/183860
Status In Force
Filing Date 2023-03-23
Publication Date 2023-09-28
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Shuler, Kyle
  • Mitchell, Andrew
  • Muñoz, Eric
  • Sperduto, John
  • Hudson, Matthew

Abstract

The invention relates to myotropic extracellular vesicle compositions comprising a muscle-targeting membrane protein and optionally one or more therapeutic agents. The invention further relates to methods of using the myotropic extracellular vesicles comprising a muscle-targeting membrane protein for therapeutic applications for treating muscular disorders, conditions, and damage in a subject.

IPC Classes  ?

  • A61K 9/51 - Nanocapsules
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
  • C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids

60.

Genital concealing underwear for trans female gender presentation

      
Application Number 18013973
Grant Number 12185768
Status In Force
Filing Date 2021-06-30
First Publication Date 2023-09-14
Grant Date 2025-01-07
Owner University of Delaware (USA)
Inventor Hall, Martha

Abstract

Garments for concealing male genitalia of a wearer, the garment having a compressible region configured to be disposed over the genitalia of the wearer. Adjustment of tensile forces exerted on the compressible region resolve to compression forces exerted by the compressible region on the wearer's genitalia. Embodiments include garments having a primary portion and a connector portion configured to connect a front portion to a back portion, the connector having an adjustable length between a connection to the front portion and connection to the back portion, wherein adjustment of the length is used for adjusting the tensile forces.

IPC Classes  ?

  • A41B 9/04 - Knickers for ladies, with or without inserted crotch or seat parts
  • A41B 9/00 - Undergarments
  • A41B 9/02 - Drawers or underpants for men, with or without inserted crotch or seat parts

61.

HUMAN SIMULATOR

      
Application Number 18143307
Status Pending
Filing Date 2023-05-04
First Publication Date 2023-08-31
Owner University of Delaware (USA)
Inventor
  • Hall, Martha
  • Zarlenga, Gabriella

Abstract

A monitoring system for use with a human simulator for simulating interaction between a human baby and a bonded human and method of operating thereof are disclosed. The simulator comprises a housing having an outer layer configured to contact the baby, the housing having a surface contoured to simulate a torso of the bonded human; a respiration simulation system configured to simulate a respiration motion of the bonded human; and a heartbeat simulation system configured to simulate a heartbeat of the bonded human. The monitoring system comprises a smart device having a first communication interface; one or more sensors for detecting one or more biological parameters of the bonded human; at least one processor programmed with machine readable instructions to activate the sensor(s) and to transmit a signal corresponding to the detected biological parameters from the first communication interface to a second communication interface connected to the simulator.

IPC Classes  ?

  • A61M 21/02 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia

62.

POSITIVE DISPLACEMENT PUMP MATERIAL DELIVERY SYSTEM FOR ADDITIVE MANUFACTURE

      
Application Number 18131669
Status Pending
Filing Date 2023-04-06
First Publication Date 2023-08-03
Owner University of Delaware (USA)
Inventor
  • Mackay, Michael E.
  • Swain, Zachary

Abstract

A positive displacement pump for an additive manufacture application includes a motor having a rotatable output shaft, at least one rotatable gear or rotatable screw that is attached to the output shaft of the motor, and a passage defined downstream of said at least one rotatable gear or rotatable screw. The gear or screw is configured to receive material, and expel the material out of the pump at a flow rate proportional to a rotation rate of the output shaft of the motor and at a constant flow rate for a fixed rotation rate of the output shaft regardless of changes in system pressure.

IPC Classes  ?

  • B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
  • B29C 64/321 - Feeding
  • F04C 2/18 - Rotary-piston machines or pumps of intermeshing-engagement type, i.e. with engagement of co-operating members similar to that of toothed gearing of other than internal-axis type with toothed rotary pistons with similar tooth forms
  • F04C 13/00 - Adaptations of machines or pumps for special use, e.g. for extremely high pressures

63.

AN ANION EXCHANGE ELECTROLYZER HAVING A PLATINUM-GROUP-METAL FREE SELF-SUPPORTED OXYGEN EVOLUTION ELECTRODE

      
Application Number 17923355
Status Pending
Filing Date 2021-05-04
First Publication Date 2023-06-29
Owner University of Delaware (USA)
Inventor
  • Yan, Yushan
  • Xiao, Junwu
  • Oliveria, Alexandra
  • Wang, Lan
  • Zhao, Yun
  • Wang, Teng
  • Wang, Junhua
  • Setzler, Brian

Abstract

Fluoride-containing nickel iron oxyhydroxide electrocatalysts for use as anodes in anion exchange membrane electrolyzers for generating hydrogen gas.

IPC Classes  ?

  • C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
  • C25B 1/04 - Hydrogen or oxygen by electrolysis of water
  • C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms
  • C25B 11/032 - Gas diffusion electrodes
  • C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
  • C25B 11/065 - Carbon
  • C25B 11/081 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the element being a noble metal

64.

ELECTROCHEMICALLY DRIVEN CARBON DIOXIDE SEPARATOR

      
Application Number 17926229
Status Pending
Filing Date 2021-05-20
First Publication Date 2023-06-22
Owner University of Delaware (USA)
Inventor
  • Yan, Yushan
  • Matz, Stephanie
  • Yan, David
  • Razdan, Rohan
  • Setzler, Brian

Abstract

Electrochemical devices including electrochemically-driven carbon dioxide separators are disclosed, the devices including electrodes comprised of an anion exchange polymer and a charge storage compound such as nickel hydroxide and a membrane comprising an anion exchange poiymer, the membrane having a channel for inflow of a carbon dioxide-containing gas within the membrane.

IPC Classes  ?

  • B01D 53/32 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
  • H01M 12/06 - Hybrid cellsManufacture thereof composed of a half-cell of the fuel-cell type and of a half-cell of the primary-cell type with one metallic and one gaseous electrode
  • H01M 8/0662 - Treatment of gaseous reactants or gaseous residues, e.g. cleaning

65.

Medical treatment simulation devices

      
Application Number 18092505
Grant Number 12154456
Status In Force
Filing Date 2023-01-03
First Publication Date 2023-05-11
Grant Date 2024-11-26
Owner University of Delaware (USA)
Inventor
  • Cowperthwait, Amy
  • Erol, Amy Bucha
  • Collins, Olivia
  • Devenny, Andrew

Abstract

Medical treatment simulation systems and devices are disclosed. One device includes an overlay, a simulated treatment structure, at least one feedback device, and at least one processor. The overlay is configured to be secured to the live subject and to cover at least a portion of a body of the live subject. The simulated treatment structure is configured to simulate a structure associated with the medical procedure. The at least one feedback device is configured to provide a feedback signal to the live subject. The at least one processor is connected to the simulated treatment structure and the at least one feedback device. The processor is programmed to operate the feedback device to provide the feedback signal based upon input generated from interaction between a treatment provider and the simulated treatment structure. The disclosed devices may be used to simulate intravenous, catheter, defibrillation, and/or thoracic treatments.

IPC Classes  ?

  • G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
  • G09B 23/30 - Anatomical models

66.

Ion-conducting bio-based polymers from raw lignocellulosic biomass

      
Application Number 17980792
Grant Number 12291592
Status In Force
Filing Date 2022-11-04
First Publication Date 2023-04-13
Grant Date 2025-05-06
Owner University Of Delaware (USA)
Inventor
  • Epps, Iii, Thomas H.
  • Holmberg, Angela L.
  • Nicastro, Kaleigh H.
  • Wang, Shu
  • Saha, Basudeb
  • Shuai, Li
  • Vlachos, Dionisios G.
  • Morris, Melody A.

Abstract

Disclosed herein is a bio-based copolymer comprising in polymerized form (i) at least one polymerizable bio-based monomer containing one phenolic hydroxyl group which has been derivatized to provide at least one polymerizable functional group which is an ethylenically unsaturated functional group (such as a [meth]acrylate group), where the precursors of the polymerizable bio-based monomers are derived from raw lignin-containing biomass, and (ii) at least one ion-conducting co-monomer other than the bio-based monomer. Also disclosed herein are binders comprising the bio-based copolymer, electrodes comprising the binder, polymer electrolytes comprising the bio-based copolymer and an electrochemical device comprising an electrode in electrical contact with a polymer electrolyte, wherein at least one of the electrode and the polymer electrolyte comprises the bio-based copolymer.

IPC Classes  ?

  • C08F 212/14 - Monomers containing only one unsaturated aliphatic radical containing one ring substituted by hetero atoms or groups containing hetero atoms
  • B32B 27/30 - Layered products essentially comprising synthetic resin comprising vinyl resinLayered products essentially comprising synthetic resin comprising acrylic resin
  • C07C 41/18 - Preparation of ethers by reactions not forming ether-oxygen bonds
  • C07C 41/38 - SeparationPurificationStabilisationUse of additives by liquid-liquid treatment
  • C07C 67/14 - Preparation of carboxylic acid esters from carboxylic acid halides
  • C07C 69/618 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
  • C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
  • C08G 83/00 - Macromolecular compounds not provided for in groups
  • C09J 7/38 - Pressure-sensitive adhesives [PSA]
  • C09J 9/02 - Electrically-conducting adhesives
  • C09J 125/18 - Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen
  • C09J 133/08 - Homopolymers or copolymers of acrylic acid esters
  • C09J 153/00 - Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsAdhesives based on derivatives of such polymers
  • H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
  • H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
  • C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
  • C08H 8/00 - Macromolecular compounds derived from lignocellulosic materials

67.

Processes for depositing functionalized nanoparticles upon a substrate

      
Application Number 17983818
Grant Number 11999650
Status In Force
Filing Date 2022-11-09
First Publication Date 2023-03-09
Grant Date 2024-06-04
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Thostenson, Erik
  • Schumacher, Thomas

Abstract

Processes for depositing functionalized nanoparticles upon a non-conductive substrate are disclosed herein. The processes may include the step of aerosolizing one or more particles into suspension within a gas, each of the one or more particles comprising functionalized nanoparticles having an electric charge. The processes may include the step the step of attracting the one or more particles onto a non-conductive substrate by a static electric charge opposite of the electric charge, wherein at least portions of the non-conductive substrate are having the static electric charge. The processes may include the step of depositing the functionalized nanoparticles onto the non-conductive substrate.

IPC Classes  ?

  • C25D 13/02 - Electrophoretic coating characterised by the process with inorganic material
  • C03C 25/44 - Carbon, e.g. graphite
  • C09D 5/44 - Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects producedFilling pastes for electrophoretic applications
  • C25D 13/12 - Electrophoretic coating characterised by the process characterised by the article coated
  • C25D 13/22 - Servicing or operating
  • C08K 3/04 - Carbon
  • C09D 7/61 - Additives non-macromolecular inorganic

68.

COAXIAL DIELECTRIC BARRIER DISCHARGE PLASMA BIPHASIC MICROREACTOR FOR CONTINUOUS OXIDATIVE PROCESSES

      
Application Number US2022041174
Publication Number 2023/028034
Status In Force
Filing Date 2022-08-23
Publication Date 2023-03-02
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Dimitrakellis, Panagiotis
  • Cameli, Fabio
  • Vlachos, Dionisios G.

Abstract

A reactor assembly for igniting and sustaining a plasma and method for performing a reaction. The assembly includes an elongated cylindrical inner electrode; a dielectric tube arranged helically around the elongated cylindrical inner electrode to form a helical reactor. The reactor assembly also includes an annular outer electrode arranged around at least a portion of the exterior of the helical reactor. The assembly includes a power source to provide a voltage across the elongated cylindrical inner electrode and the annular outer electrode. A process stream including at least a gas flows through the dielectric tube. The voltage is applied across the elongated cylindrical inner electrode and the annular outer electrode such that at least a portion of the flow of the process stream through the dielectric tube is exposed to the voltage and the plasma is ignited and sustained.

IPC Classes  ?

  • H05H 1/24 - Generating plasma
  • H05H 1/42 - Plasma torches using an arc with provisions for introducing materials into the plasma, e.g. powder or liquid
  • H05H 1/00 - Generating plasmaHandling plasma
  • H01J 37/32 - Gas-filled discharge tubes
  • H05H 1/46 - Generating plasma using applied electromagnetic fields, e.g. high frequency or microwave energy

69.

PRODUCTION OF LIGNIN DERIVED RENEWABLE LUBRICANTS

      
Application Number US2022039739
Publication Number 2023/015037
Status In Force
Filing Date 2022-08-08
Publication Date 2023-02-09
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Ebikade, Elvis, Osamudiamhen
  • Sadula, Sunitha
  • Liu, Sibao
  • Vlachos, Dionisios, G.

Abstract

Disclosed herein are bio-based compositions comprising branched aromatic compounds and/or branched cycloaliphatic compounds, and methods of their preparation from lignin-derived monomers, and their use as base oils in lubricant compositions, personal care compositions, and pharmaceutical compositions.

IPC Classes  ?

  • C10M 109/02 - Reaction products
  • C10M 169/04 - Mixtures of base-materials and additives
  • C10G 1/00 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal

70.

SEMICONDUCTOR DEVICE AND FABRICATION METHODS THEREOF

      
Application Number 17836487
Status Pending
Filing Date 2022-06-09
First Publication Date 2022-12-15
Owner University of Delaware (USA)
Inventor
  • Cui, Peng
  • Zeng, Yuping

Abstract

A semiconductor device and fabricating method thereof is disclosed. The method comprises depositing epitaxial layers over a silicon substrate to form a semiconductor layer surface; forming at least one mesa portion on the semiconductor layer surface; depositing a metal stack on the semiconductor layer surface; subjecting the semiconductor layer surface to a rapid thermal annealing system for a two-step ohmic contact annealing in H2/N2 forming gas (FG) and then nitrogen; subjecting the semiconductor layer surface to an oxygen plasma treatment; and depositing a T-shaped metal gate on the semiconductor layer surface. A semiconductor device comprises a semiconductor layer surface having an epitaxial layer disposed over a silicon substrate; at least one mesa portion formed on the semiconductor layer surface; a metal stack, disposed on the semiconductor layer surface, and sequentially annealed in FG and nitrogen; and a T-shaped metal gate on the semiconductor layer surface.

IPC Classes  ?

  • H01L 29/66 - Types of semiconductor device
  • H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
  • H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
  • H01L 21/324 - Thermal treatment for modifying the properties of semiconductor bodies, e.g. annealing, sintering
  • H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

71.

MICRORNAS ENRICHED IN MEGAKARYOCYTIC EXTRACELLULAR VESICLES AND USES THEREOF

      
Application Number 17770433
Status Pending
Filing Date 2020-10-21
First Publication Date 2022-11-24
Owner University of Delaware (USA)
Inventor
  • Papoutsakis, Eleftherios
  • Kao, Chen-Yuan
  • Jiang, Jinlin

Abstract

The present invention relates to a method for inducing megakaryocytic differentiation of hematopoietic stem/progenitor cells (HSPCs). The method comprises transferring into the HSPCs an effective amount of small RNAs. The HSPCs may differentiate into megakaryocytes in the absence of thrombopoietin (TPO) and/or without using megakaryocytic microparticles (MkMPs). The small RNAs may be micro RNAs (miRs) selected from the group consisting of miR-486, miR-22, miR-191, miR-181, miR-378, miR-26, let-7, miR-92, miR-126, miR-92, miR-21, miR-146, miR-181, and combinations thereof. For example, the small RNAs are miR-486 and miR-22. The small RNAs may be synthetic or isolated from cells. Also provided is a method for enhancing megakaryocytic differentiation of HSPCs cultured with megakaryocytic microparticles MkMPs in the presence of an effective amount of one or more exogenous small RNAs (e.g., miR-486).

IPC Classes  ?

  • C12N 5/078 - Cells from blood or from the immune system
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

72.

INDIRECT THREE-DIMENSIONAL CO-CULTURE OF DORMANT TUMOR CELLS AND USES THEREOF

      
Application Number 17764593
Status Pending
Filing Date 2020-09-30
First Publication Date 2022-11-10
Owner University of Delaware (USA)
Inventor
  • Kloxin, April
  • Pradhan, Lina
  • Sikes, Robert
  • Van Golen, Kenneth
  • Moore, Devonte

Abstract

The present invention relates to an indirect three-dimensional co-culture. The indirect co-culture may comprise bone marrow niche cells, tumor cells and a culture medium. The bone marrow niche cells and the tumor cells may be incubated in the culture medium without direct contact between the bone marrow niche cells and the tumor cells. The tumor cells may be dormant or reactivated. Also provided are a method for preparing the indirect co-culture and a method for screening for an agent capable of inhibiting reactivation of dormant tumor cells or promoting dormancy of proliferating tumor cells.

IPC Classes  ?

  • C12N 5/09 - Tumour cells
  • C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells

73.

EX VIVO LYMPH NODE AND USES THEREOF

      
Application Number 17641254
Status Pending
Filing Date 2020-09-16
First Publication Date 2022-10-20
Owner University of Delaware (USA)
Inventor
  • Gleghorn, Jason Paul
  • Zurakowski, Ryan Mark

Abstract

The present invention provides an ex vivo lymph node is provided. The ex vivo lymph node comprises an intact lobule in a chamber connected to an afferent lymphatic vessel and an efferent lymphatic vessel. The intact lobule is perfused with a lymphatic fluid into the chamber via the afferent lymphatic vessel and out of the chamber via the efferent lymphatic vessel and perfused with a vascular fluid into the intact lobule via an endogenous artery and out of the intact lobule via an endogenous vein. Also provided is a method for preparing the ex vivo lymph node. Further provided are methods for screening for an agent capable of changing the ex vivo lymph node, producing T lymphocytes or B lymphocytes and determining immunoreactivity of the ex vivo lymph node.

IPC Classes  ?

  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
  • C12N 5/078 - Cells from blood or from the immune system
  • A01N 1/02 - Preservation of living parts
  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • C12N 5/0781 - B cellsProgenitors thereof

74.

Low-pressure depolymerization of lignocellulosic biomass

      
Application Number 17634271
Grant Number 12358858
Status In Force
Filing Date 2020-08-14
First Publication Date 2022-10-13
Grant Date 2025-07-15
Owner University Of Delaware (USA)
Inventor
  • Ebikade, Elvis O.
  • Gottlieb, Eric R.
  • O'Dea, Robert M.
  • Epps, Iii, Thomas H.
  • Vlachos, Dionisios

Abstract

3 are independently selected from H or methoxy group.

IPC Classes  ?

  • C07C 37/00 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
  • B01D 3/00 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
  • B01D 36/00 - Filter circuits or combinations of filters with other separating devices
  • C07C 41/01 - Preparation of ethers
  • C07C 41/18 - Preparation of ethers by reactions not forming ether-oxygen bonds

75.

Biofunctional thiophene monomers and polymers thereof for electronic biomedical devices

      
Application Number 17637108
Grant Number 12252582
Status In Force
Filing Date 2020-08-28
First Publication Date 2022-09-15
Grant Date 2025-03-18
Owner University Of Delaware (USA)
Inventor
  • Martin, David C.
  • Nagane, Samadhan Suresh
  • Sitarik, Peter

Abstract

6 is replaced by a direct bond to an amide group, an azide group, or an ester group of a biofunctional hydrocarbyl moiety. Also, disclosed herein are polymers and copolymers made therefrom.

IPC Classes  ?

  • C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
  • C07D 495/04 - Ortho-condensed systems
  • C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
  • C07J 33/00 - Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton
  • H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances

76.

CATALYTIC HYDROCONVERSION OF POLYPROPYLENE-BASED PLASTIC WASTE TO LUBRICANT BASE-OILS

      
Application Number US2022019667
Publication Number 2022/192484
Status In Force
Filing Date 2022-03-10
Publication Date 2022-09-15
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Vlachos, Dionisios, G.
  • Liu, Sibao
  • Vance, Brandon
  • Wang, Cong
  • Kots, Pavel

Abstract

The present disclosure provides a process for converting plastic comprising a polyolefin polymer to a lubricant. The process comprises contacting the plastic with a catalyst represented by A/[RmQn],(I)

IPC Classes  ?

  • C10G 1/10 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal from rubber or rubber waste
  • C10G 1/06 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal by destructive hydrogenation
  • C10M 177/00 - Special methods of preparation of lubricating compositionsChemical modification by after-treatment of components or of the whole of a lubricating composition, not covered by other classes
  • B01J 21/06 - Silicon, titanium, zirconium or hafniumOxides or hydroxides thereof
  • B01J 21/08 - Silica
  • B01J 23/40 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of noble metals of the platinum group metals
  • B01J 23/74 - Iron group metals

77.

High-Gain, Wide-Angle, Multi-Beam, Multi-Frequency Beamforming Lens Antenna

      
Application Number 17826057
Status Pending
Filing Date 2022-05-26
First Publication Date 2022-09-08
Owner University of Delaware (USA)
Inventor
  • Biswas, Soumitra
  • Jetmundsen, Howard
  • Rogers, Shawn
  • Cox, Harold Thomas
  • Mirotznik, Mark

Abstract

A high-gain, wide-angle, multi-beam, multi-frequency beamforming lens antenna that includes a Luneburg lens with at least one planar interface in the southern hemisphere of the Luneburg lens and a planar ultrawideband modular antenna (PUMA array) structure. The PUMA array structure is connected to at least one of the planar interfaces of the Luneburg lens and is configured to function as a feed network to illuminate cells of the Luneburg lens simultaneously.

IPC Classes  ?

  • H01Q 25/00 - Antennas or antenna systems providing at least two radiating patterns
  • H01Q 5/25 - Ultra-wideband [UWB] systems, e.g. multiple resonance systemsPulse systems
  • H01Q 21/00 - Antenna arrays or systems
  • H01Q 3/46 - Active lenses or reflecting arrays
  • H01Q 15/02 - Refracting or diffracting devices, e.g. lens, prism
  • H01Q 15/08 - Refracting or diffracting devices, e.g. lens, prism formed of solid dielectric material
  • H01Q 19/06 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using refracting or diffracting devices, e.g. lens

78.

BIO-BASED POLYSULFONES AND USES THEREOF

      
Application Number 17616245
Status Pending
Filing Date 2020-06-11
First Publication Date 2022-08-11
Owner
  • University of Delaware (USA)
  • Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Epps, Iii, Thomas H.
  • Korley, Lashanda T. J.
  • Green, Matthew D.
  • Mahajan, Jignesh S.
  • Behbahani, Hoda Shokrollahzadeh

Abstract

Disclosed herein are bio-based polysulfones, and in particular, bisguaiacol-based PSfs synthesized from (i) at least one polymerizable lignin-based monomer having a structure corresponding to formula (I) wherein each R1 is independently either an H or a methyl group, wherein R2, R3, and R4 are each individually selected from an H or a methoxy group, and (ii) at least one polymerizable 4,4′-dihalophenyl sulfone as a comonomer. Also, disclosed herein are compositions comprising the bio-based polysulfones and a membrane comprising the composition Disclosed herein are bio-based polysulfones, and in particular, bisguaiacol-based PSfs synthesized from (i) at least one polymerizable lignin-based monomer having a structure corresponding to formula (I) wherein each R1 is independently either an H or a methyl group, wherein R2, R3, and R4 are each individually selected from an H or a methoxy group, and (ii) at least one polymerizable 4,4′-dihalophenyl sulfone as a comonomer. Also, disclosed herein are compositions comprising the bio-based polysulfones and a membrane comprising the composition

IPC Classes  ?

  • C08G 75/20 - Polysulfones
  • C08L 81/06 - PolysulfonesPolyethersulfones
  • B01D 71/68 - PolysulfonesPolyethersulfones
  • B01D 61/02 - Reverse osmosisHyperfiltration
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
  • C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
  • H01M 8/1004 - Fuel cells with solid electrolytes characterised by membrane-electrode assemblies [MEA]
  • H01M 8/1032 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having sulfur, e.g. sulfonated-polyethersulfones [S-PES]

79.

OXIDATION RESISTANT POLYMERS FOR USE AS ANION EXCHANGE MEMBRANES AND IONOMERS

      
Application Number US2022015189
Publication Number 2022/170022
Status In Force
Filing Date 2022-02-04
Publication Date 2022-08-11
Owner
  • UNIVERSITY OF DELAWARE (USA)
  • VERSOGEN, INC. (USA)
Inventor
  • Yan, Yushan
  • Hu, Keda
  • Wang, Lan
  • Setzler, Brian
  • Shi, Wenjuan
  • Wang, Junhua

Abstract

Hydroxide-exchange membranes (HEMs) and hydroxide-exchange ionomers (HEIs) are provided which include polymers with oxidation resistant groups. The attachment of the oxidation resistant groups to the polymer backbone allows fine-tuning of the mechanical properties of the membrane and incorporation of alkaline stable cations, such as imidazoliums, phosphoniums and ammoniums, and provides enhanced stability to the polymer. HEMs/HEIs formed from these polymers exhibit superior chemical stability, anion conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional HEM/HEIs. The HEMs exhibit enhanced stability in a highly oxidative environment.

IPC Classes  ?

  • C08K 5/375 - Sulfides containing six-membered aromatic rings
  • C09J 181/02 - PolythioethersPolythioether-ethers
  • C09J 5/00 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers

80.

ALGICIDAL SHEWANELLA BACTERIA OR ITS FILTRATE IMMOBILIZED TO POROUS MATRICES AND USES THEREOF

      
Application Number 17619356
Status Pending
Filing Date 2020-06-26
First Publication Date 2022-08-04
Owner University of Delaware (USA)
Inventor
  • Coyne, Kathryn J.
  • Wang, Yanfei

Abstract

The present invention provides an algicidal composition comprising Shewanella strain IRI-160 or a filtrate of a Shewanella strain IRI-160 culture, a matrix and a medium. The Shewanella strain IRI-160 or the filtrate is immobilized to the matrix. Also provided are methods for preparing the algicidal composition and using the algicidal composition for inhibiting growth of a dinoflagellate.

IPC Classes  ?

  • A01N 63/20 - BacteriaSubstances produced thereby or obtained therefrom
  • C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
  • C12N 1/20 - BacteriaCulture media therefor
  • C12N 11/10 - Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate

81.

PREVENTION OF POSTERIOR CAPSULAR OPACIFICATION (PCO) WITH INTEGRIN AVB8 BLOCKING ANTIBODY

      
Application Number US2022013738
Publication Number 2022/164818
Status In Force
Filing Date 2022-01-25
Publication Date 2022-08-04
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • UNIVERSITY OF DELAWARE (USA)
Inventor
  • Sheppard, Dean
  • Bidlingmaier, Scott
  • Liu, Bin
  • Atakilit, Amha
  • Duncan, Melinda K.
  • Shihan, Mahbubul H.

Abstract

Methods to treat or prevent posterior capsular opacification (PCO) using antibodies that inhibit αvβ8 ligand adhesion are provided.

IPC Classes  ?

  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61P 27/02 - Ophthalmic agents
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells

82.

Reagents and methods for tetrazine synthesis

      
Application Number 17492016
Grant Number 11767302
Status In Force
Filing Date 2021-10-01
First Publication Date 2022-04-07
Grant Date 2023-09-26
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Fox, Joseph M.
  • Lambert, William
  • Fang, Yinzhi
  • Am Ende, Christopher William
  • Mahapatra, Subham
  • Xie, Yixin
  • Wang, Chuanqi

Abstract

Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.

IPC Classes  ?

  • C07D 257/08 - Six-membered rings
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 403/08 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing alicyclic rings
  • C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07F 5/02 - Boron compounds
  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
  • B01J 31/24 - Phosphines
  • B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
  • B01J 31/22 - Organic complexes
  • C07J 43/00 - Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton

83.

Method and system for dynamic capillary-driven additive manufacturing of continuous fiber composite

      
Application Number 17404365
Grant Number 11897194
Status In Force
Filing Date 2021-08-17
First Publication Date 2022-02-17
Grant Date 2024-02-13
Owner University of Delaware (USA)
Inventor
  • Fu, Kelvin
  • Shi, Baohui

Abstract

A process for additive manufacturing of a thermoset resin fiber reinforced composite comprises depositing a fiber material along a path having a direction; heating the fiber material using a heater to generate a moving thermal gradient in the fiber material trailing the heater relative to the path direction; and dispensing a thermosetting polymer material on the heated fiber material at a trailing distance the from the heater along the path. The thermosetting polymer dynamically wicks into the fiber material along the thermal gradient in the path direction.

IPC Classes  ?

  • B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
  • B29C 64/321 - Feeding
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
  • B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
  • B29K 307/04 - Carbon
  • B29K 63/00 - Use of epoxy resins as moulding material

84.

METHOD TO THERMO-REVERSIBLY CONTROL LIGHT AND HEAT FLOW WITH BICONTINUOUS MICRO-DOMAIN

      
Application Number US2021070989
Publication Number 2022/027017
Status In Force
Filing Date 2021-07-27
Publication Date 2022-02-03
Owner
  • UNIVERSITY OF DELAWARE (USA)
  • GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (USA)
Inventor
  • Xi, Yuyin
  • Liu, Yun

Abstract

A dynamically tunable composition, a device including the composition, a method of dynamically tuning radiation transmission through the composition, and a method of thermo-reversibly controlling operation of a filter formed from the composition. The composition includes a plurality of nanoparticles dispersed in a single phase region of a binary solvent systems composed of a first solvent and a second solvent, the nanoparticles having a preferential wettability to the first solvent. Changing temperature of the composition causes it to transition thermo-reversibly from the liquid state to a gel state having bi-continuous domains, including a particle domain and a solvent domain. The particle domain features nanoparticles dispersed in a first- solvent-rich fraction of the binary solvent system, and the solvent domain is a second- solvent-rich fraction of the binary solvent system. Exemplary devices incorporating the composition include a filter, a temperature sensor, a smart window, a smart display, a battery, and a tissue growth scaffold.

IPC Classes  ?

  • C08F 2/46 - Polymerisation initiated by wave energy or particle radiation
  • B82Y 40/00 - Manufacture or treatment of nanostructures
  • B82Y 99/00 - Subject matter not provided for in other groups of this subclass
  • G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
  • C08F 2/00 - Processes of polymerisation

85.

VIBRATIONAL DEVICE AND METHODS FOR MITIGATING SYMPTOMS OF FREEZING OF GAIT

      
Application Number 17413337
Status Pending
Filing Date 2019-12-12
First Publication Date 2022-01-20
Owner University of Delaware (USA)
Inventor
  • Pretzer-Aboff, Ingrid
  • Martin, Richard D.
  • Chase, David Bruce
  • Jones, Scott
  • Rabolt, John F.

Abstract

A device adapted to be secured to the foot of a user includes one or more vibration actuators configured to provide vibrations to the user's foot, one or more force or acceleration sensors configured to sense forces or acceleration exerted by the user's foot, and a controller configured to operate the vibration actuators in a continuous mode to provide intermittent vibration to the user's foot independent of information sensed by the force or acceleration sensors. The vibration includes a first period of continuous vibration followed by a second period of no vibration followed by a third period of continuous vibration. The device may also be configured to operate in a feedback mode.

IPC Classes  ?

  • A43B 7/14 - Footwear with health or hygienic arrangements with foot-supporting parts
  • A43B 3/00 - Footwear characterised by the shape or the use
  • A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
  • A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
  • G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising

86.

GENITAL CONCEALING UNDERWEAR FOR TRANS FEMALE GENDER PRESENTATION

      
Application Number US2021039867
Publication Number 2022/006257
Status In Force
Filing Date 2021-06-30
Publication Date 2022-01-06
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Hall, Martha
  • Zhang, Haobo
  • Dyes, Caitlin

Abstract

Garments for concealing male genitalia of a wearer, the garment having a compressible region configured to be disposed over the genitalia of the wearer. Adjustment of tensile forces exerted on the compressible region resolve to compression forces exerted by the compressible region on the wearer's genitalia. Embodiments include garments having a primary portion and a connector portion configured to connect a front portion to a back portion, the connector having an adjustable length between a connection to the front portion and connection to the back portion, wherein adjustment of the length is used for adjusting the tensile forces.

IPC Classes  ?

  • A41B 9/02 - Drawers or underpants for men, with or without inserted crotch or seat parts
  • A41B 9/00 - Undergarments
  • A41B 9/04 - Knickers for ladies, with or without inserted crotch or seat parts
  • A41B 9/08 - Combined undergarments
  • A41B 9/12 - Protective undergarments
  • A41B 9/16 - Shoulder-straps forming part of the undergarments
  • A61F 5/451 - Genital receptacles

87.

HYDROCRACKING CATALYSTS AND USES THEREOF

      
Application Number US2021037751
Publication Number 2021/257783
Status In Force
Filing Date 2021-06-17
Publication Date 2021-12-23
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Liu, Sibao
  • Vlachos, Dionisios, G.

Abstract

ababb)] and the moiety Z are mechanically mixed; wherein the weight percentage of the moiety Z is about 1% to about 99% of the total weight of the catalyst. Furthermore, the present disclosure provides a tunable, low-temperature, energy- efficient process for hydrocracking plastics to form a fuel, a lubricant, or a mixture thereof.

IPC Classes  ?

  • C10G 1/10 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal from rubber or rubber waste
  • C10G 47/16 - Crystalline alumino-silicate carriers
  • B01J 29/74 - Noble metals
  • B01J 35/10 - Solids characterised by their surface properties or porosity

88.

Extracellular vesicles as biomarkers and therapeutics for neuromuscular disorders

      
Application Number 17270674
Grant Number 12371653
Status In Force
Filing Date 2019-08-23
First Publication Date 2021-11-11
Grant Date 2025-07-29
Owner
  • University of Delaware (USA)
  • Iowa State University Research Foundation, Inc. (USA)
Inventor
  • Hudson, Matthew B.
  • Selsby, Joshua T.

Abstract

This invention relates to extracellular vesicles and method of isolated tissue-specific extracellular vesicles from bodily fluids. The invention further relates to methods of using extracellular vesicles for diagnostic applications for detecting and monitoring diseases, conditions, and damage in a subject. The invention also relates to methods of using extracellular vesicles for therapeutic applications for treating diseases, conditions, and damage in a subject.

IPC Classes  ?

  • C12N 1/02 - Separating microorganisms from their culture media
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

89.

AN ANION EXCHANGE MEMBRANE ELECTROLYZER HAVING A PLATINUM-GROUP-METAL FREE SELF-SUPPORTED OXYGEN EVOLUTION ELECTRODE

      
Application Number US2021030696
Publication Number 2021/226119
Status In Force
Filing Date 2021-05-04
Publication Date 2021-11-11
Owner UNIVERSITY OF DELAWARE (USA)
Inventor
  • Yan, Yushan
  • Xiao, Junwu
  • Oliveria, Alexandra
  • Wang, Lan
  • Zhao, Yun
  • Wang, Teng
  • Wang, Junhua
  • Setzler, Brian

Abstract

Fluoride-containing nickel iron oxyhydroxide electrocatalysts for use as anodes in anion exchange membrane electrolyzers for generating hydrogen gas.

IPC Classes  ?

  • B01J 23/76 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups
  • C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds

90.

Multi-room in-home harness system

      
Application Number 16384404
Grant Number 11135112
Status In Force
Filing Date 2019-04-15
First Publication Date 2021-10-05
Grant Date 2021-10-05
Owner
  • Arizona Board of Regents acting for and on behalf of Northern Arizona University (USA)
  • University of Delaware (USA)
Inventor
  • Winfree, Kyle N.
  • Galloway, James Cole

Abstract

A multi-room in-home harness system is disclosed. Specific implementations may include a first plurality of tracks including a first track system in a first room, a trolley that may be configured to moveably couple to a track of the first plurality of tracks and move along a horizontal plane of the track, and a cart coupled to the trolley, where the trolley may be configured to move the cart along each track of the first plurality of tracks and may also be configured to transfer the cart from the first plurality of tracks to a second plurality of tracks in a second room.

IPC Classes  ?

  • A61G 7/10 - Devices for lifting patients or disabled persons, e.g. special adaptations of hoists thereto

91.

BIOMEMBRANE-COVERED NANOPARTICLES (BIONPS) FOR DELIVERING ACTIVE AGENTS TO STEM CELLS

      
Application Number 17327932
Status Pending
Filing Date 2021-05-24
First Publication Date 2021-09-09
Owner University of Delaware (USA)
Inventor
  • Papoutsakis, Eleftherios T.
  • Day, Emily
  • Winter, Erica
  • Harris, Jenna
  • Kao, Chen-Yuan
  • Das, Samik

Abstract

The present invention provides bio-nanoparticles (BioNPs) for delivering an active agent into hematopoietic stem & progenitor cells (HSPCs). Each BioNP comprises a core and a biological membrane covering the core, which comprises the active agent and a polymer. The biological membrane comprises a phospholipid bilayer and one or more surface proteins of a megakaryocyte (Mk). The active agent remains active after being delivered into the HSPC. Also provided are methods for preparing the BioNPs and uses of the BioNPs for targeted delivery of an active agent into HSPCs and/or treating or preventing a disease or condition in a subject in need thereof.

IPC Classes  ?

  • A61K 9/51 - Nanocapsules
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

92.

Methods for producing silver-amended carbon materials

      
Application Number 17258798
Grant Number 11974875
Status In Force
Filing Date 2019-07-12
First Publication Date 2021-09-02
Grant Date 2024-05-07
Owner University of Delaware (USA)
Inventor
  • Chiu, Pei-Chun
  • Xin, Danhui
  • Lobo, Ii, Steven

Abstract

Silver-amended carbon materials containing silver nanoparticles are prepared by a process involving an initial reduction of a porous carbon material, followed by contacting the reduced porous carbon material with an aqueous solution of a silver salt. Such silver-amended carbon materials may contain a relatively high loading of silver nanoparticles on both the outside surface and within the interior of the porous carbon material and are useful for disinfecting and/or otherwise purifying fluids such as microbe-containing fluids.

IPC Classes  ?

  • C01B 32/05 - Preparation or purification of carbon not covered by groups , , ,
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
  • A61B 6/58 - Testing, adjusting or calibrating thereof
  • B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes

93.

Methods for inducing bioorthogonal reactivity

      
Application Number 17132532
Grant Number 11485987
Status In Force
Filing Date 2020-12-23
First Publication Date 2021-06-03
Grant Date 2022-11-01
Owner University of Delaware (USA)
Inventor
  • Fox, Joseph M.
  • Thorpe, Colin
  • Tallon, Amanda M.
  • Xie, Yixin
  • Trout, William
  • Cantrel, Ashlyn S.
  • Rosenberger, Julia E.

Abstract

A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein the dihydrotetrazine 1 comprises a first R group and a second R group, wherein the first R group is a substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the second R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, and heteroatom-containing groups; wherein the method comprises (a) providing the dihydrotetrazine 1 in a reaction medium, and (b) adding an enzyme as a catalyst and an oxidant to the reaction medium, whereby the dihydrotetrazine 1 is converted to the tetrazine 2.

IPC Classes  ?

  • C12P 17/12 - Nitrogen as only ring hetero atom containing a six-membered hetero ring
  • C12P 17/16 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing two or more hetero rings

94.

Increasing water retention in soil to mitigate drought

      
Application Number 17045010
Grant Number 12378166
Status In Force
Filing Date 2019-04-03
First Publication Date 2021-05-20
Grant Date 2025-08-05
Owner University of Delaware (USA)
Inventor
  • Bais, Harsh
  • Jin, Yan

Abstract

Bacillus subtilis UD1022 to the soil composition to improve water retention of the soil composition.

IPC Classes  ?

  • C05D 9/00 - Other inorganic fertilisers
  • A01N 25/08 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
  • A01N 63/22 - Bacillus
  • C09K 17/16 - Soil-conditioning materials or soil-stabilising materials containing organic compounds only applied in a physical form other than a solution or a grout, e.g. as platelets or granules
  • C12N 1/20 - BacteriaCulture media therefor
  • C12R 1/125 - Bacillus subtilis

95.

Electrochemical generation of carbon-containing products from carbon dioxide and carbon monoxide

      
Application Number 17044379
Grant Number 11959184
Status In Force
Filing Date 2019-04-11
First Publication Date 2021-05-13
Grant Date 2024-04-16
Owner University of Delaware (USA)
Inventor
  • Jiao, Feng
  • Jouny, Matthew
  • Lv, Jing-Jing

Abstract

Disclosed herein is a method of electroreduction with a working electrode and counter electrode. The method includes a step of electrocatalyzing carbon monoxide and/or carbon dioxide in the presence of one or more nucleophilic co-reactants in contact with a catalytically active material present on the working electrode, thereby forming one or more carbon-containing products electrocatalytically.

IPC Classes  ?

  • C25B 3/03 - Acyclic or carbocyclic hydrocarbons
  • C25B 1/23 - Carbon monoxide or syngas
  • C25B 3/07 - Oxygen containing compounds
  • C25B 3/09 - Nitrogen containing compounds
  • C25B 3/25 - Reduction
  • C25B 3/26 - Reduction of carbon dioxide
  • C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms

96.

Layered mixed-matrix membranes and mixed-matrix composites from polymers and active materials

      
Application Number 16638817
Grant Number 11504673
Status In Force
Filing Date 2018-08-15
First Publication Date 2021-05-06
Grant Date 2022-11-22
Owner
  • GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE DEFENSE THREAT REDUCTION AGENCY (USA)
  • GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY (USA)
  • UNIVERSITY OF DELAWARE (USA)
Inventor
  • Peterson, Gregory W.
  • Lu, Annie
  • Epps, Iii, Thomas H.
  • Epps, Jean S.

Abstract

Disclosed herein are multi-layer structures comprising a first composite layer disposed over a second composite layer, wherein the first composite layer contains a first active material dispersed in a first polymer containing an elastomeric polymer and the second composite layer contains a second polymer which may have a second active material dispersed therein, wherein the first active material chemically or physically interacts with at least one toxic chemical and is selected from the group consisting of metal-organic frameworks (MOFs), metal oxides, metal hydroxides, zeolites, and combinations thereof, and wherein the active material and the second active material (if present) are the same as or different from each other, and the first polymer and second polymer are the same as or different from each other, subject to the proviso that the first composite layer and the second composite layer compositionally differ from each other in at least one respect.

IPC Classes  ?

  • B01D 69/12 - Composite membranesUltra-thin membranes
  • B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
  • B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
  • B01D 69/14 - Dynamic membranes
  • B01D 71/02 - Inorganic material
  • B01D 71/80 - Block polymers
  • B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
  • B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
  • B32B 27/18 - Layered products essentially comprising synthetic resin characterised by the use of special additives
  • B32B 27/30 - Layered products essentially comprising synthetic resin comprising vinyl resinLayered products essentially comprising synthetic resin comprising acrylic resin

97.

Modular artificial skeletal muscle actuators and exoskeletons powered thereby

      
Application Number 17117904
Grant Number 12083067
Status In Force
Filing Date 2020-12-10
First Publication Date 2021-04-29
Grant Date 2024-09-10
Owner University of Delaware (USA)
Inventor
  • Behboodi, Ahad
  • Lee, Samuel C. K.
  • Binder-Macleod, Stuart A.
  • Wright, Henry

Abstract

A modular artificial skeletal muscle (MASM) actuator having a plurality of dielectric elastomer units assembled in series or in parallel. A proximal anchoring member is connected to a proximal end of at least one proximal dielectric elastomer unit and is configured for attachment to a proximal anchor point relative to a user. A tension member has a proximal end attached to a distal end of at least one distal dielectric elastomer unit and a distal end configured for attachment to a distal anchor point relative to the user. A controller is configured to cause simultaneous contraction or expansion of plurality of dielectric elastomer units, which contraction or expansion causes displacement of the tension member. A plurality of MASM actuators may be attached to an exoskeleton attached about an ankle of a user and controlled for therapeutic purposes, such as for assisting pediatric patients with cerebral palsy.

IPC Classes  ?

  • A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
  • A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

98.

FURAN BASED COMPOSITIONS AND METHODS OF MAKING THEREOF

      
Application Number 16639314
Status Pending
Filing Date 2018-08-17
First Publication Date 2021-02-11
Owner University of Delaware (USA)
Inventor
  • Saha, Basudeb
  • Liu, Sibao
  • Vlachos, Dionisios

Abstract

Disclosed herein are processes for the preparation of compounds of formula (I) from one or more bio-derived reactants, and their use as base oils: Disclosed herein are processes for the preparation of compounds of formula (I) from one or more bio-derived reactants, and their use as base oils: (R1-A)b-(CHx)a(CHR2)m—(C(R4R5))n—(CHR3)o—(CHy)c-(A-R1′)d  (I) Disclosed herein are processes for the preparation of compounds of formula (I) from one or more bio-derived reactants, and their use as base oils: (R1-A)b-(CHx)a(CHR2)m—(C(R4R5))n—(CHR3)o—(CHy)c-(A-R1′)d  (I) wherein a and c are independently 0 or 1, b and d are independently 1 or 2, x and y are independently 1 or 2, dependent upon the values of a-d, m and o are independently 0 or 1, n is an integer of 0-6, and each A is independently an unsaturated furan ring, a partially saturated furan ring, a saturated furan ring, or —(CH2)4—. Also, R1, R1′, R2, R3, R4 and R5 are independently selected from the group consisting of H and alkyl groups having 1 to 18 carbon atoms, with a proviso that at least one of R2, R3, R4, and R5 is not hydrogen, and the total carbon content of the compound of formula (I) is in the range of 20-62.

IPC Classes  ?

  • C07D 307/10 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
  • A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61Q 19/00 - Preparations for care of the skin
  • A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
  • C07D 307/38 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
  • C10M 105/18 - Ethers, e.g. epoxides
  • C10M 105/04 - Well-defined hydrocarbons aliphatic
  • C10M 111/02 - Lubricating compositions characterised by the base-material being a mixture of two or more compounds covered by more than one of the main groups , each of these compounds being essential at least one of them being a non-macromolecular organic compound
  • C07C 1/22 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms by reduction

99.

Electrochemical devices and fuel cell systems

      
Application Number 17073696
Grant Number 11757120
Status In Force
Filing Date 2020-10-19
First Publication Date 2021-02-04
Grant Date 2023-09-12
Owner University of Delaware (USA)
Inventor
  • Yan, Yushan
  • Setzler, Brian

Abstract

Electrochemical devices including electrochemical pumps (ECPs) and fuel cell systems comprising a fuel cell and an ECP are disclosed. In particular, this electrochemical device can be an ECP that comprises an anode, a cathode and an anion exchange polymer separating the anode from the cathode. The ECP can be coupled to a hydroxide exchange membrane fuel cell (HEMFC) that is disclosed herein as a fuel cell system. These devices can be used in methods for removing carbon dioxide from air and for generating electricity.

IPC Classes  ?

  • H01M 8/0612 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants from carbon-containing material
  • H01M 8/0656 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants by electrochemical means
  • H01M 8/0662 - Treatment of gaseous reactants or gaseous residues, e.g. cleaning
  • H01M 4/92 - Metals of platinum group
  • H01M 8/1018 - Polymeric electrolyte materials
  • H01M 8/0258 - CollectorsSeparators, e.g. bipolar separatorsInterconnectors characterised by the configuration of channels, e.g. by the flow field of the reactant or coolant
  • H01M 4/90 - Selection of catalytic material
  • B01D 53/32 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
  • H01M 8/10 - Fuel cells with solid electrolytes

100.

Poly(aryl piperidinium) polymers including those with stable cationic pendant groups for use as anion exchange membranes and ionomers

      
Application Number 16651622
Grant Number 11512156
Status In Force
Filing Date 2018-09-28
First Publication Date 2021-01-14
Grant Date 2022-11-29
Owner University of Delaware (USA)
Inventor
  • Yan, Yushan
  • Hu, Keda
  • Wang, Junhua
  • Wang, Lan
  • Xu, Bingjun
  • Zhao, Yun

Abstract

Poly(aryl piperidinium) polymers with pendant cationic groups are provided which have an alkaline-stable cation, piperidinium, introduced into a rigid aromatic polymer backbone free of ether bonds. Hydroxide exchange membranes or hydroxide exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional hydroxide exchange membranes or ionomers. Hydroxide exchange membrane fuel cells comprising the poly(aryl piperidinium) polymers with pendant cationic groups exhibit enhanced performance and durability at relatively high temperatures.

IPC Classes  ?

  • C08F 26/08 - N-Vinyl-pyrrolidine
  • B01J 41/14 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
  • H01M 8/10 - Fuel cells with solid electrolytes
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