Abstract

Disclosed is a coating composition that includes at least one silane or functionalized silane, and at least one electroactive or electroconductive polymer, and optionally a solvent. In particular, the coating composition comprises a mixture of octadecyltrichlorosilane and poly(3,4-ethylenedioxythiophene):polystyrene sulfonate.

IPC Classes  ?

• C09D 5/16 - Anti-fouling paintsUnderwater paints
• C09D 5/24 - Electrically-conducting paints
• C09D 7/63 - Additives non-macromolecular organic
• C09D 165/00 - Coating compositions based on macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCoating compositions based on derivatives of such polymers

Abstract

Provided herein are compositions to treat Clostridioides difficile (C. difficile), Mycobacterium tuberculosis (M. tuberculosis) and Enterococcus faecalis (E. faecalis). These compositions are related to the known compounds (+)-Puupehenone and (+)-ent-Chromazonarol, which are both naturally occurring products. The new compositions were shown to potently inhibit both growth and toxin production of C. difficile as well as inhibit the growth and survival of both replicating and dormant M. tuberculosis. In the United States the C. difficile burden is approximately 453,000 hospital cases and 29,000 deaths annually. Globally, about 10 million people fall ill from tuberculosis and 1.4 million died from the disease. In addition, the known compound (+)-ent-Chromazonarol (10) was found for the first time to strongly inhibit the growth of E. faecalis. E. faecalis has grown drug resistant to vancomycin. In 2017, Vancomycin-Resistant Enterococci (VRE) caused an estimated 54,500 infections among hospitalized patients and 5,400 estimated deaths in the United States.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 31/04 - Antibacterial agents
• C07D 311/78 - Ring systems having three or more relevant rings

Abstract

Community-associated and hospital acquired infections caused by bacteria and viruses on surfaces are global challenges to human health. New strategies that offer non-specific and broad protection are urgently needed. Irradiated cerium nanoparticles IrCNPs are provided which optionally are synthesized with a metal such as silver. These nanoparticles are designed to have superior function due to a higher trivalent (Ce3+Pseudomonas aeruginosa, Staphylococcus aureusS. aureusS. aureus, both species and biofilm, within 3 hours of exposure, and are effective against viruses as well.

IPC Classes  ?

• C01F 17/235 - Cerium oxides or hydroxides
• A61K 9/51 - Nanocapsules
• A61P 31/04 - Antibacterial agents
• B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

The present disclosure is directed to a hydrogen selective catalytic reduction catalyst composition effective for reducing nitrogen oxides using hydrogen gas, wherein the hydrogen selective catalytic reduction catalyst composition comprises a first component comprising a metal component supported by an oxide support and a second component comprising a zeolite; a selective catalytic reduction article effective for catalyzing the reduction of nitrogen oxides using hydrogen gas comprising such a hydrogen selective catalytic reduction catalyst composition; and a method for treating an exhaust stream containing nitrogen oxides using an emissions treatment system comprising such a hydrogen selective catalytic reduction catalyst composition.

IPC Classes  ?

• B01D 53/94 - Chemical or biological purification of waste gases of engine exhaust gases by catalytic processes

Abstract

An optical fiber may include a cladding structure extending along a fiber length providing a hollow interior fiber region and one or more sets of anti-resonant (AR) elements formed as walled structures with walls extending along the fiber length. The one or more sets of AR elements may be distributed around an interior wall of the cladding structure and, configured to guide light along the fiber length in a central portion of the hollow interior fiber region based on optical anti-resonance. At least one of the one or more sets of AR elements may comprise a first AR element, two or more support structures disposed on an inner surface of the first AR element, and a second AR element disposed on at least one of the two or more support structures.

IPC Classes  ?

• G02B 6/032 - Optical fibres with cladding with non-solid core or cladding
• C03B 37/025 - Manufacture of glass fibres or filaments by drawing or extruding from reheated softened tubes, rods, fibres or filaments
• G02B 6/02 - Optical fibres with cladding
• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers

Abstract

A system comprises an airflow pathway; a nozzle configured to inject the liquid into the airflow pathway; and a pintle disposed within the nozzle such that an end of the pintle contacts the liquid injected into the airflow pathway, wherein the pintle is configured to impart vibratory energy unto the liquid injected into the airflow pathway.

IPC Classes  ?

• B05B 17/06 - Apparatus for spraying or atomising liquids or other fluent materials, not covered by any other group of this subclass operating with special methods using ultrasonic vibrations
• F02M 27/08 - Apparatus for treating combustion-air, fuel, or fuel-air mixture, by catalysts, electric means, magnetism, rays, sonic waves, or the like by sonic or ultrasonic waves
• F02M 61/16 - Details not provided for in, or of interest apart from, the apparatus of groups

Abstract

A signal transmitted by a trusted transmitter is sampled, and a machine-learning algorithm is trained using these samples to learn to distinguish the signal characteristics of the trusted transmitter from the signal characteristics of other transmitters. The machine-learning parameters learned to distinguish the trusted transmitter's signals can then be exported allowing other devices to authenticate signals from the trusted transmitter. Since the signal characteristics of the trusted transmitter is based on manufacturing variations, the transmitters of unauthorized users should be unable to replicate the signal characteristics of the trusted transmitter. Thus, the transmitters of unauthorized users should not be usable to spoof a device that uses the exported parameters to authenticate messages from the trusted transmitter.

IPC Classes  ?

• H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
• H04L 9/40 - Network security protocols
• H04W 12/122 - Counter-measures against attacksProtection against rogue devices

Abstract

Described herein relates to a system and method for autonomous vehicle navigation. The technique may combine a Hybrid Predictive Network (HPN) and a Value Function Network (VFN), along with a safety prioritizer, to enhance decision-making and safety. The HPN, built on a symmetric encoder-decoder architecture, may utilize a series of observations to predict future scenarios. The VFN may also estimate state-action value functions, combining HPN's predictive capabilities with decision-making, improving navigation. A multi-step prediction chain may also use the HPN to generate future hypotheses based on observation history. The safety prioritizer, integrated within the VFN, may be configured to penalize high-risk actions, masking them when selected, increasing safety. Additionally, the system may apply deep reinforcement learning for high-level policy creation for safe tactical decision-making. The method may optimize social utility and/or may increase sample efficiency and safety, making significant strides in autonomous vehicle operation.

IPC Classes  ?

• B60W 60/00 - Drive control systems specially adapted for autonomous road vehicles
• B60W 50/00 - Details of control systems for road vehicle drive control not related to the control of a particular sub-unit
• G06N 3/092 - Reinforcement learning

Abstract

Disclosed are compositions and methods relating to the treatment of a cancer.

IPC Classes  ?

• A61K 40/15 - Natural-killer [NK] cellsNatural-killer T [NKT] cells
• A61K 38/20 - Interleukins
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/41 - Vertebrate antigens
• A61P 35/00 - Antineoplastic agents
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

An augmented reality (AR) chemistry training system is disclosed, featuring a video see-through AR (VST-AR) device that captures a real-world scene and overlays interactive virtual content. A physical laboratory vessel analog (corporal entity) is equipped with capacitive tactile sensors on its exterior to detect user touch and grasp. A unique identification marker on the vessel allows the system's at least one processor to recognize the vessel type and retrieve corresponding parameters (such as virtual liquid properties) from a data store. In real-time, the processor generates visual augmentations inside the vessel, representing virtual chemicals that respond to the user's touch and motions. This tactile-responsive AR system safely simulates hands-on chemistry experiences—such as mixing liquids—by providing realistic visual reactions coupled with touch-based feedback, thereby enhancing user immersion and skill development.

IPC Classes  ?

• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06F 3/16 - Sound inputSound output

Abstract

An augmented reality chemistry system is presented that combines visual and thermal feedback to create immersive laboratory simulations. A video see-through AR headset or device captures the user's real environment and overlays virtual chemical reactions inside a physical analog vessel. The physical vessel analog is instrumented with a thermal diode embedded in its structure, capable of safely heating or cooling its surface to simulate exothermic or endothermic reactions. A unique marker on the vessel is tracked by the AR device, enabling a processor to anchor virtual liquid visuals to the vessel and retrieve predetermined reaction parameters from a database. As virtual reactions occur (e.g. mixing chemicals), the system dynamically adjusts the vessel's temperature via the thermal diode in sync with the visual augmentation, so the user can feel temperature changes corresponding to the reaction. This AR apparatus enriches remote chemistry training by providing realistic heat feedback and interactive visualizations without real hazardous materials.

IPC Classes  ?

• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06F 3/16 - Sound inputSound output

Abstract

A class of nanowires that possess enzyme-like catalytic activities, which are termed as “enzyme mimics”. The morphologies of such enzyme mimics are nanoscale wires (i.e., nanowires) of various lengths, diameters, and degrees of branching and bending. The composition of such enzyme mimics may contain various elements, but at least one is a platinum-group metal [including platinum (Pt), iridium (Ir), rhodium (Rh), palladium (Pd), and/or ruthenium (Ru)]. The nanowires as enzyme mimics can efficiently catalyze multiple chemical reactions that are typically catalyzed by natural enzymes (such as peroxidase, catalase, oxidase, and superoxide dismutase). For example, the nanowires can act as peroxidase mimics and catalyze the oxidation of chromogenic substrates by oxidizing agents (e.g., hydrogen peroxide), yielding colored products. In addition, disclosed here include the applications of such enzyme mimics in biosensing systems, wherein the enzyme mimics arc conjugated to bioreceptors (e.g., antibodies) and are used as labels or reporters.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• B01J 23/46 - Ruthenium, rhodium, osmium or iridium
• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• B01J 31/22 - Organic complexes
• B01J 35/45 - Nanoparticles
• B01J 35/58 - Fabrics or filaments
• B01J 37/16 - Reducing
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

Disclosed herein are three-dimensional culture system for producing cartilage and/or selecting therapeutic agents for promoting cartilage regeneration.

IPC Classes  ?

• A61K 31/4748 - QuinolinesIsoquinolines forming part of bridged ring systems
• A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61K 31/475 - QuinolinesIsoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61L 27/20 - Polysaccharides
• A61L 27/22 - Polypeptides or derivatives thereof
• A61L 27/38 - Animal cells
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A thulium fiber is described. The thulium fiber is designed for in-band pumping. The thulium fiber may take advantage of higher efficiencies and lower thermal load associated with in-band pumping. The thulium fiber may include a triple clad design. The triple clad design may offer a balance between thermal effects, modulation instability thresholds, and pump absorption. The thulium fiber may provide greater than 5 kilowatts of continuous wave (CW) output power across the 1950-2100 nanometer region.

IPC Classes  ?

• G02B 6/02 - Optical fibres with cladding
• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers

Abstract

The system extracts water from lunar regolith and includes a regolith intake having a digging bucket that collects lunar regolith soil and a gravel separator that separates and discharges gravel and passes a mixture of ice-regolith powder having ice grains that are about 10-100 microns along the conveyor. A pneumatic separator receives the ice-regolith powder and pneumatically splits the ice-regolith powder into streams of different sized lithic fragments and ice particles per the ratio of inertial force and aerodynamic drag force of the lithic fragments and ice particles. Each split stream may include a magnetic separator that separates further the magnetic and paramagnetic lithic fragments from ice particles to discharge up to 80 percent of lithic fragments to slag.

IPC Classes  ?

• E21C 51/00 - Apparatus for, or methods of, winning materials from extraterrestrial sources
• B03C 1/30 - Combinations with other devices, not otherwise provided for
• B03C 7/02 - Separators
• B04C 9/00 - Combinations with other devices, e.g. fans
• B64G 4/00 - Tools specially adapted for use in space
• B64G 5/00 - Ground equipment for vehicles, e.g. starting towers, fuelling arrangements

Abstract

An IR sensor comprises a substrate, a rear reflector on the substrate, a supporting layer, a PCM layer carried by the supporting layer and comprising a PCM material, and a second dopant material different than the PCM material, and first and second electrically conductive contacts carried by the substrate and coupled to opposing sides of the PCM layer. The IR sensor also includes a circuit coupled to the first and second electrically conductive contacts and configured to apply an electrical bias signal to the PCM layer to generate an electrical oscillation, and detect the frequency modulation (FM) of the oscillation signal based upon IR radiation received by the PCM layer.

IPC Classes  ?

• G01J 5/24 - Use of specially adapted circuits, e.g. bridge circuits
• G01J 5/02 - Constructional details
• G01J 5/34 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors using capacitors, e.g. pyroelectric capacitors

Abstract

Systems and methods to improve efficiency of in-coupling into, propagating through, and out-coupling from, electromagnetic waves (e.g., in a visible light wavelength range), a waveguide system arrangement. The waveguide system arrangement includes an illumination assembly; an in-coupler, a waveguide substrate, and a parallelepiped prisms array structure, which efficiently couple electromagnetic waves (e.g., in a visible light wavelength range), horizontally propagating through the waveguide substrate, and the parallelepiped prisms array structure out-couples the electromagnetic waves (e.g., in a visible light wavelength range), from the waveguide substrate. In one implementation, the waveguide system arrangement includes an augmented reality display system and the out-coupled light provides a virtual image that is overlaid on an image of a real object with both images seen by a viewer's eye. An ultracompact liquid-crystal on silicon (LCoS) display system is also disclosed. The LCoS display system exhibits excellent light uniformity, optical efficiency, and contrast ratio.

IPC Classes  ?

• F21V 8/00 - Use of light guides, e.g. fibre optic devices, in lighting devices or systems
• G02B 27/01 - Head-up displays
• G02F 1/13357 - Illuminating devices

Abstract

A mode transformation device may include a tapered waveguide having a first face and a second face separated along a guiding direction, where a cross-section of the tapered waveguide at the first face comprises an arrangement of three or more guiding structures, and where the three or more guiding structures include at least a first guiding structure surrounded by a second guiding structure surrounded by third guiding structure. A cross-sectional dimension of at least one of the three or more guiding structures adiabatically changes along the guiding direction such that light propagating through the tapered waveguide has a first optical mode profile at the first face and a second optical mode at the second face, where the light transitions from the first optical mode profile to the second optical mode profile as it propagates along the guiding direction.

IPC Classes  ?

• G02B 6/30 - Optical coupling means for use between fibre and thin-film device

Abstract

e.ge.ge.g., for treating or preventing a disease).

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61K 31/33 - Heterocyclic compounds

Abstract

Systems and methods to improve efficiency of in-coupling electromagnetic waves, such as in a visible light wavelength range, into a waveguide system arrangement are disclosed. The waveguide system includes: a display or an illumination assembly; a waveguide substrate; a polarization volume grating or a spin-dependent bifacial metasurface as in-coupler, which efficiently couples electromagnetic waves, such as in a visible light wavelength range, into the waveguide substrate. An out-coupler can couple the electromagnetic waves, such as in a visible light wavelength range, out of the waveguide substrate.

IPC Classes  ?

• G02B 27/01 - Head-up displays

Abstract

An integral-proportional (IP)/proportional-integral (PI) (IPPI) controller is blended through a single parameter for voltage and current control. When the parameter is optimized, the IPPI controller delivers a superior transient response, improved stability margins, and wider operating ranges for voltage source converters (VSCs) in comparison to conventional standalone PI controllers.

IPC Classes  ?

• H02M 7/483 - Converters with outputs that each can have more than two voltage levels
• G05B 19/4155 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme
• H02M 1/00 - Details of apparatus for conversion

Abstract

Described herein relates to a method that may be used for synthesizing a bifunctional electrocatalyst for electrochemical water splitting. The method may involve anodically converting an electrodeposited iron-nickel alloy film into an iron-nickel-oxygen nanofilm, followed by sequential phosphorization and/or selenylation treatments via chemical vapor deposition to form a quaternary iron-nickel phosphoselenide nanoporous film. This self-supported catalyst can facilitate both hydrogen evolution and oxygen evolution reactions, improving electrolysis efficiency. The inclusion of selenium may enhance electrical conductivity and stabilize catalytic performance, while the nanoporous structure can optimize mass transport. The film may be used as both anode and cathode in a two-electrode electrolyzer, enabling hydrogen production from pure water or seawater. Notably, the catalyst can demonstrate high turnover frequency and low overpotential, potentially surpassing conventional noble-metal-based catalysts. The system's stability under prolonged operation may underscore its potential for scalable hydrogen generation, reducing reliance on fossil fuels and advancing renewable energy applications.

IPC Classes  ?

• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• B01J 27/185 - PhosphorusCompounds thereof with iron group metals or platinum group metals
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 35/30 - Catalysts, in general, characterised by their form or physical properties characterised by their physical properties
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/28 - Phosphorising
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds

Abstract

Method for predicting severity of COVID-19 disease resulting from infection with SARS-COV-2 (severe acute respiratory syndrome coronavirus 2). The method uses a high dimensional approach to construct a comprehensive metabolic landscape of immune cells participating in the anti-viral response against SARS-CoV-2. Also encompassed within the invention are novel immune cell subsets exhibiting metabolic dysfunction that could serve as predictive biomarkers for COVID-19 severity or as targets for therapeutic interventions in COVID-19 disease.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/14 - Antivirals for RNA viruses
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• G01N 15/10 - Investigating individual particles
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
• G16B 40/30 - Unsupervised data analysis
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

Malaria still afflicts about half of the world population causing more than 400,000 deaths, mostly children. The options for malaria therapy are increasingly becoming limited because of widespread drug resistance. Furthermore, drugs for prophylaxis are suboptimal. This disclosure reports the identification of type II protein kinase inhibitor compounds which have never been explored as antimalarial agents and which now have been discovered to possess therapeutic and prophylactic properties against malaria.

IPC Classes  ?

• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 33/06 - Antimalarials
• C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond

Abstract

A screening gas diffusion material, which can have a porosity and which can be a layer and which can be a membrane, for use in electrolysis systems and methods, such as in an electrolyzer, permits smaller molecules, such as methanol, to pass through while excluding larger organic contaminants from reaching the catalyst surface. The screening layer minimizes the energy penalty caused by the larger organic impurities while maintaining the cell potential below the threshold where catalysts are potentially oxidized.

IPC Classes  ?

• C25B 1/02 - Hydrogen or oxygen
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 11/032 - Gas diffusion electrodes
• C25B 11/065 - Carbon
• C25B 11/097 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds comprising two or more noble metals or noble metal alloys
• C25B 13/05 - DiaphragmsSpacing elements characterised by the material based on inorganic materials
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes
• H01M 4/88 - Processes of manufacture
• H01M 4/92 - Metals of platinum group
• H01M 8/0234 - Carbonaceous material

Abstract

Nanoparticles comprising miR-211 and their use for treating brain cancers, such as medulloblastomas, including pediatric medulloblastomas, are disclosed.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Antineoplastic agents
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

Described herein relates to a system and method for optimizing a physical patient examination through augmented reality (AR), virtual reality (VR), mixed reality (MR), and/or extended reality (XR) to augment the appearance of the physical patient representation and/or to simulate physical movements, aspects, and/or behaviors that the physical patient representation is not capable of on its own, while also affording the ability to provide physical contact with the physical patient representation. Additionally, these enhancements may offer several benefits in the healthcare domain, such as improved learning, training, mentoring, practice, and/or case planning. Furthermore, these enhancements may be useful for other domains, such as biology education, clothing retail, and any service or activity involving human representations.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

A power system for an engine that can be used in an aircraft, a marine vessel or a land vehicle has a storage tank containing ammonia. An engine supported on the vehicle is configured to operate using hydrogen gas as fuel. A cracking device in or adjacent the engine receives heat from operation of the engine, e.g., from a compressor or a combustion chamber, and also receives ammonia from the storage tank, and it uses the heat from the engine to dissociate the ammonia to produce hydrogen gas. The cracking device supplies the hydrogen gas to the engine, which has a combustor in which combustion of the hydrogen gas takes place. The energy from the combustion drives the engine so as to provide mechanical energy.

IPC Classes  ?

• F23R 3/36 - Supply of different fuels
• F23R 3/16 - Continuous combustion chambers using liquid or gaseous fuel characterised by the air-flow or gas-flow configuration with devices inside the flame tube or the combustion chamber to influence the air or gas flow
• F23R 3/34 - Feeding into different combustion zones

Abstract

The invention provides a method for adapting a text-to-image (T2I) diffusion model for video editing by using spectral decomposition to achieve controlled spectral shifts in the model's weights. This adaptation involves maintaining constant singular vectors while selectively adjusting singular values in response to a text prompt. A spectral shift regularizer constrains adjustments, particularly limiting changes to larger singular values to ensure minimal deviation from the original model's structure. This approach allows efficient, prompt-driven video editing by modifying specific elements according to the prompt while preserving the original video context. By focusing on selective spectral adjustments, the method reduces adaptation time and computational demands, making it suitable for real-time and resource-sensitive applications, such as dynamic video editing for streaming services.

IPC Classes  ?

• G11B 27/031 - Electronic editing of digitised analogue information signals, e.g. audio or video signals
• G06F 40/40 - Processing or translation of natural language

Abstract

A screening gas diffusion material, which can have a porosity and which can be a layer and which can be a membrane, for use in electrolysis systems and methods, such as in an electrolyzer, permits smaller molecules, such as methanol, to pass through while excluding larger organic contaminants from reaching the catalyst surface. The screening layer minimizes the energy penalty caused by the larger organic impurities while maintaining the cell potential below the threshold where catalysts are potentially oxidized.

IPC Classes  ?

• C25B 9/15 - Flow-through cells
• C25B 9/17 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof
• H01M 4/88 - Processes of manufacture
• H01M 4/92 - Metals of platinum group
• C25B 1/02 - Hydrogen or oxygen
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes

Abstract

A novel anti-microbial coating and uses thereof on medical devices are presented. The novel coating is comprised of a layer of boron carbon nitride (BCN) coated onto a medical device such as a catheter. The BCN coating was found to inhibit bacterial growth by at least 80% and reduce biofilm formation by at least 60% on the treated surface of the catheter. This coating can be used to reduce or prevent central line associated bloodstream infections (CLABSI) in patients as well as inhibit bacterial growth and biofilm formation on a variety of medical devices or polymeric surfaces.

IPC Classes  ?

• A61L 29/10 - Inorganic materials
• A61L 29/04 - Macromolecular materials
• A61L 29/16 - Biologically active materials, e.g. therapeutic substances

Abstract

The present invention relates to an advanced augmented reality, AR, apparatus featuring a video see-through AR, VST-AR, device that captures images of a real-world environment and displays augmented versions on a screen. The system includes a corporal entity, such as an empty laboratory vessel, equipped with a unique identification marker. This marker provides real-time spatial data for generating visual augmentations representing virtual matter within the vessel. The apparatus integrates various sensors, including an inertial measurement unit, IMU, capacitive tactile sensors, and a thermal diode, to dynamically adjust visual augmentations based on user interactions. Additional sensory enhancements include an olfactory output fan, an eccentric rotating mass, ERM, motor, and auditory outputs. Wireless connectivity via IEEE 802.11 (Wi-Fi) and IEEE 802.15.1 (Bluetooth) ensures seamless communication between components. This AR system is particularly valuable for educational and laboratory settings, offering realistic, interactive simulations.

IPC Classes  ?

• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06F 3/16 - Sound inputSound output

Abstract

Disclosed are compositions and methods relating to the treatment of a cancer via the induction of PDL1 and use of anti-PDL1 antibodies.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 38/20 - Interleukins
• A61K 40/15 - Natural-killer [NK] cellsNatural-killer T [NKT] cells
• A61K 40/22 - Immunosuppressive or immunotolerising
• A61K 40/42 - Cancer antigens
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

A quantum cascade laser (QCL) may include multiple branch waveguide regions having one or more laser cores providing optical gain at one or more output wavelengths, a stem waveguide region, and multiple couplers arranged to couple light from the plurality of branch waveguide regions to the stem waveguide region. Each of the couplers may include two or more curved waveguide regions having a continuously-varying radius of curvature providing that a fundamental transverse mode at the output wavelengths is dominant, and a coupler to combine light from the two or more curved waveguides and maintain dominance of the fundamental transverse mode at the output wavelengths. The fundamental transverse mode at the output wavelengths may be dominant in output light from the stem waveguide.

IPC Classes  ?

• H01S 5/10 - Construction or shape of the optical resonator
• H01S 5/34 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers

Abstract

Hybridization probes have been used in the detection of specific nucleic acids for the last 50 years. Despite the extensive efforts and the great significance, the challenges of the commonly used probes include (1) low selectivity in detecting single nucleotide variations (SNV) at low (e.g., room or 37° C.) temperatures; (2) low affinity in binding folded nucleic acids, and (3) the cost of fluorescent probes. To address all three issues, a multicomponent hybridization probe, called OWL2 sensor, is introduced. OWL2 sensor uses two analyte binding arms to tightly bind and unwind folded nucleic acid analytes, and two sequence-specific strands that bind both the analyte and a universal molecular beacon (UMB) probe to form fluorescent ‘OWL’ structure. OWL2 sensor can differentiate single base variations in folded analytes in a temperature range of 5-38° C. The design is cost-efficient since the same optimized fluorescently labeled UMB probe can be used for the detection of any analyte sequence.

IPC Classes  ?

• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Disclosed is a hydrogel and hydrogel-based foam, which are made of a naturally-derived material, alginate hydrogel in combination with CaCO3, glucono delta-lactone (GDL), and sodium lauryl ether sulfate, as well as methods for making alginate hydrogel and alginate hydrogel foam, which have radiological and mechanical properties equivalent to those of human lung. The material is environment-friendly, and the hydrogel properties can be readily adjusted by changing the alginate concentration, Ca2+ ratio, and solution volume in the container. The hydrogel and hydrogel foam disclosed here have potential to be used for making tissue-equivalent phantoms of various human organs, in particular human lung, for radiotherapy dosimetry, and other applications such as bioimplants, artificial biological tissues, soft robotics, and optics.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• G09B 23/30 - Anatomical models

Abstract

A photonic switch system includes an optical chip having an optical input configured to receive an optical signal into the optical chip and an optical output configured to output the optical signal from the optical chip in an ON state. The optical chip defines an optical path from the optical input to the optical output in the ON state. A moveable member is included in the optical path proximate the optical input and a stationary member is included in the optical path proximate the optical output. In the ON state, the optical path runs from the optical input, into the moveable member, through the moveable member, into the stationary member, though the stationary member, and to the optical output. In an OFF state, the optical path diverts away from the optical output.

IPC Classes  ?

• G02B 6/35 - Optical coupling means having switching means

Abstract

Disclosed are compositions and methods relating to the expansion of memory NK cells.

IPC Classes  ?

• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 35/33 - Fibroblasts
• A61K 38/20 - Interleukins
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

A method for training a deep learning model configured for virtual screening of molecules for micro ribonucleic acid (miRNA) drug discovery includes creating a training dataset including a plurality of assay datasets. The method also includes training the deep learning model to learn a plurality of tasks; performing, using the deep learning model, inference for the respective task associated with at least one miRNA assay dataset; and evaluating respective performance metrics associated with the respective predictions for each of the plurality of tasks. The method further includes selecting a set of the plurality of assay datasets for training; and training the deep learning model to learn a set of the plurality of tasks using the set of the plurality of assay datasets. The trained deep learning model is configured to predict molecules capable of affecting a target miRNA.

IPC Classes  ?

• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• C40B 30/06 - Methods of screening libraries by measuring effects on living organisms, tissues or cells
• G16B 35/20 - Screening of libraries

Abstract

An optical fiber may include a cladding structure extending along a fiber length providing a hollow interior fiber region, and anti-resonant (AR) elements formed as walled structures with walls extending along the fiber length. At least one of the AR elements surrounds an interior region and further includes one or more support structures in the interior region and formed as at least a portion of at least one of the walls, where the one or more support structures have a non-uniform thickness profile, and where the plurality AR elements is configured to guide light along the fiber length in a central portion of the hollow interior fiber region based on optical anti-resonance.

IPC Classes  ?

• G02B 6/032 - Optical fibres with cladding with non-solid core or cladding
• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers

Abstract

Multifunctional cerium oxide-P7C3 (aminopropyl carbazole) chimeric nanocompositions and methods for using these nanocompositions for enhancing bone deposition are provided. For example, these nanocompositions can be used to combat radiation-induced bone tissue/cell damage, to treat any disorders that promote osteoporosis, and/or to treat bone trauma/injury.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

A glass fiber-based structural composite offers an alternative or supplement to carbon fibers in areas such as battery storage. Through electroless deposition of conductive materials like copper and nickel, the glass fiber surface is made conducting and functions as a good current collector. By using anode and cathode materials like manganese (II, III) oxide and Zinc, cathode and anode mats on the copper- and nickel-coated glass fibers are created via hydrothermal and electro-deposition methods. In one example application, the anode and cathode mats are in an alternate square patterned arrangement using copper and nickel-coated glass fiber as a current collector. The device, with a capacity of >300 mAh/g at 0.1 A/g is assembled using an alternate system of epoxy and electrolyte. Uncoated pristine glass fiber ladened and patterned with electrolyte are used as a separator. Uncoated pristine glass fiber ladened with epoxy can be used as an insulator between two devices.

IPC Classes  ?

• B60L 50/64 - Constructional details of batteries specially adapted for electric vehicles
• B60L 50/40 - Electric propulsion with power supplied within the vehicle using propulsion power supplied by capacitors
• B62D 29/04 - Superstructures characterised by material thereof predominantly of synthetic material
• H01G 11/04 - Hybrid capacitors
• H01G 11/10 - Multiple hybrid or EDL capacitors, e.g. arrays or modules
• H01G 11/26 - Electrodes characterised by their structure, e.g. multi-layered, porosity or surface features
• H01G 11/52 - Separators
• H01G 11/62 - Liquid electrolytes characterised by the solute, e.g. salts, anions or cations therein
• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
• H01M 10/058 - Construction or manufacture
• H01M 50/437 - Glass
• H01M 50/44 - Fibrous material
• H01M 50/457 - Separators, membranes or diaphragms characterised by the material having a layered structure comprising three or more layers

Abstract

A method of domain knowledge learning by developing a language model from medical data. One application of the invention includes the steps of receiving a medical examination dataset, executing a data processing procedure, and providing an automatic short answer grading mechanism. The method also includes determining a final decision of the grade by aggregating the deciding factors in the final grade and reporting the results' uncertainty.

IPC Classes  ?

• G06N 3/094 - Adversarial learning
• G06F 40/295 - Named entity recognition
• G16H 70/00 - ICT specially adapted for the handling or processing of medical references

Abstract

Described herein relates to a system and method of water treatment that integrates green sorption media with nanofiltration for the effective removal of perfluoroalkyl substances and/or polyfluoroalkyl substances (PFAS) from contaminated fluid. As such, the water filtration system may include a filtration chamber configured to pretreat the fluid prior to membrane filtration via the green sorption media. The green sorption media may comprise natural and/or recycled materials, including but not limited to sand, clay, perlite, and/or optionally zero-valent iron (ZVI), which pre-treats the fluid by adsorbing the perfluoroalkyl substances and/or polyfluoroalkyl substances. Additionally, the water treatment system may further comprise a crossflow nanofiltration chamber having at least one nanofiltration membrane configured to remove additional PFAS through size exclusion and/or electrostatic repulsion. The combined approach within the water treatment system may enhance the overall removal efficiency, particularly for the PFAS, while also reducing membrane fouling and/or extending operational life.

IPC Classes  ?

• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
• C02F 101/14 - Fluorine or fluorine-containing compounds

Abstract

An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

IPC Classes  ?

• A61L 27/30 - Inorganic materials
• A61L 27/04 - Metals or alloys
• A61L 27/10 - Ceramics or glasses
• A61L 27/14 - Macromolecular materials
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• C25D 13/02 - Electrophoretic coating characterised by the process with inorganic material
• C25D 13/12 - Electrophoretic coating characterised by the process characterised by the article coated
• C25D 13/18 - Electrophoretic coating characterised by the process using modulated, pulsed or reversing current
• C25D 15/00 - Electrolytic or electrophoretic production of coatings containing embedded materials, e.g. particles, whiskers, wires

Abstract

The compositions, methods, and systems described herein are useful in treating subjects suffering from or at risk of developing Intrauterine Growth Restriction.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
• A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
• A61K 33/244 - LanthanidesCompounds thereof
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 9/50 - Microcapsules
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

Efficient lung cancer treatment is challenging due to the lack of therapeutic targets. The succinate dehydrogenase (SDH) enzyme plays a critical metabolic role as an intermediate between the citric acid cycle and the electron transport chain associated with the cancer disease state. Although several existing compounds have been applied to target metabolic diseases in vitro, modulating SDH for lung cancer treatment has been elusive. By integrating the AtomNet® technology for compound identification with mitochondria- and cell-based enzyme activity assays, this disclosure demonstrates identification of four new small molecules that bind directly to SDH subunits in lung cancer cells. Mechanistically, treatment with these small molecules increased reactive oxygen species and DNA damage in lung cancer cell lines. Functionally, these small molecules reduced short-term and long-term malignant growth of lung cancer cell lines in vitro. This study provides a new therapeutic approach for targeting lung and other types of cancers through modulation of SDH.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/33 - Heterocyclic compounds

Abstract

A method of skin anomaly assessment, measurement, and monitoring is disclosed. The three-dimensional topology of a skin anomaly is digitally scanned, and a three-dimensional model of the skin anomaly is computationally constructed. From the three-dimensional model, length, width, depth, perimeter, and surface area measurements of the skin anomaly are derived. This information may be quantified by volume surface area, and/or distance along the surface of the anomaly, and measured against models of anticipated healing for medical monitoring and training.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring

Abstract

Disclosed herein are novel compositions and methods for stimulation of and the production or expansion of natural killer (NK) cells. Numbers of NK cells can be increased following contact with exosomes modified with one or more stimulatory peptides. Methods and compositions for the production of exosomes, wherein the exosomes comprises stimulatory peptides are also described. Also described are methods of treating cancer using the disclosed NK-stimulating exosomes or NK cells stimulated by the disclosed methods.

IPC Classes  ?

• A61K 35/13 - Tumour cells, irrespective of tissue of origin
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/20 - Interleukins
• C07K 14/54 - Interleukins [IL]
• C07K 14/55 - IL-2
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

A power semiconductor waveguide optical amplifier (P-SWA) may include an amplifier waveguide with an invertible core formed from one or more undoped heterogeneous semiconductor layers and one or more cladding layers surrounding one or more sides of the invertible core formed as one or more undoped semiconductor layers. Pump light may be coupled into the amplifier waveguide to induce the population inversion in the invertible core. Signal light may further be coupled into the amplifier waveguide and may be amplified as it propagates through the amplifier waveguide. The signal light may then exit the amplifier waveguide as amplified signal light.

IPC Classes  ?

• H01S 3/067 - Fibre lasers
• H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light
• H01S 3/16 - Solid materials
• H01S 5/026 - Monolithically integrated components, e.g. waveguides, monitoring photo-detectors or drivers
• H01S 5/04 - Processes or apparatus for excitation, e.g. pumping
• H01S 5/10 - Construction or shape of the optical resonator

Abstract

Described herein relates to a low-cost, synergistic, and/or green sorption media and methods thereof capable of removing MC-LR in-situ over different landscapes. The synergistic composition may include a mixture of a plurality of sand particles, a plurality of biochar particles, a plurality of clay particles, a plurality of zero-valent iron (hereinafter “ZVI”) iron molecules, and/or a plurality of perlite particles. In certain embodiments, the plurality of clay particles, plurality of ZVI molecules, and/or plurality of perlite particles may have an approximately equal volume percentage, with the volume percentage being less than or equal to a volume percentage of the plurality of biochar particles. Furthermore, the synergistic composition may be homogenously mixed and/or included in a media chamber of a filtration system.

IPC Classes  ?

• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
• B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• C02F 101/38 - Organic compounds containing nitrogen

Abstract

An active sparse labeling system that provides high performance and low annotation costs by performing partial instance annotation (i.e., sparse labeling) by frame level selection to annotate the most informative frames, thereby improving action detection task efficiencies. The active sparse labeling system utilizes a frame level cost estimation to determine the utility of each frame in a video based on the frame's impact on action detection. The system includes an adaptive proximity-aware uncertainty model, which is an uncertainty-based frame scoring mechanism. The adaptive proximity-aware uncertainty model estimates a frame's utility using the uncertainty of detections of the frame's proximity to existing annotations, thereby determining a diverse set of frames in a video which are effective for learning the task of dense video understanding (such as action detection). In addition, the active sparse labeling system includes a loss formulation training model (max-Gaussian weighted loss) that uses weighted pseudo-labeling.

IPC Classes  ?

• G06V 20/70 - Labelling scene content, e.g. deriving syntactic or semantic representations
• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting

Abstract

The systems disclosed herein can include a cell culture surface having a silicon oxide first layer and second layer comprising a plurality of amphiphilic molecules, each amphiphilic molecule having a positively charged portion extending from a silane portion that is bound to the silicon oxide first layer. The cell culture surface can also include extracellular matrix components and water molecules dispersed between and bonded to positively charged portions of the amphiphilic molecules. Methods of using the systems can include plating mechanically active cells onto the cell culture surface, forming a mechanically active cell culture, and maintaining the mechanically active cell culture in a mechanically active state and adhered to the cell culture surface for at least 14 days. The mechanically active cell culture can be exposed to an agent and responses of the mechanically active cell culture to the agent can be detected.

IPC Classes  ?

• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention relates to an advanced augmented reality, AR, apparatus featuring a video see-through AR, VST-AR, device that captures images of a real-world environment and displays augmented versions on a screen. The system includes a corporal entity, such as an empty laboratory vessel, equipped with a unique identification marker. This marker provides real-time spatial data for generating visual augmentations representing virtual matter within the vessel. The apparatus integrates various sensors, including an inertial measurement unit, IMU, capacitive tactile sensors, and a thermal diode, to dynamically adjust visual augmentations based on user interactions. Additional sensory enhancements include an olfactory output fan, an eccentric rotating mass, ERM, motor, and auditory outputs. Wireless connectivity via IEEE 802.11 (Wi-Fi) and IEEE 802.15.1 (Bluetooth) ensures seamless communication between components. This AR system is particularly valuable for educational and laboratory settings, offering realistic, interactive simulations.

IPC Classes  ?

• G06V 20/20 - ScenesScene-specific elements in augmented reality scenes
• G09B 19/24 - Use of tools
• G02B 27/01 - Head-up displays
• H04N 13/106 - Processing image signals
• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06F 18/24 - Classification techniques
• G06K 19/06 - Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
• G09B 23/24 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for chemistry
• G09B 5/02 - Electrically-operated educational appliances with visual presentation of the material to be studied, e.g. using film strip

Abstract

A real-time position location system can include one or more location modules configured to be attached to a user or a weapon of the user and to output location data associated with each user and one or more kinematic base station modules configured to receive the location data from each location module. The system can include a position module operatively connected to the one or more kinematic base stations and configured to determine a real-time location of each of the one or more location modules and to output module position data for each of the one or more location modules in real-time.

IPC Classes  ?

• F41G 3/26 - Teaching or practice apparatus for gun-aiming or gun-laying
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

An optical fiber may include a cladding structure extending along a fiber length providing a hollow interior fiber region, and anti-resonant (AR) elements formed as walled structures with walls extending along the fiber length. At least one of the AR elements surrounds an interior region and further includes one or more support structures in the interior region and formed as at least a portion of at least one of the walls, where the one or more support structures have a non-uniform thickness profile, and where the plurality AR elements is configured to guide light along the fiber length in a central portion of the hollow interior fiber region based on optical anti-resonance.

IPC Classes  ?

• G02B 6/032 - Optical fibres with cladding with non-solid core or cladding
• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers

Abstract

A monolithically 3D printed array of microchannels in a multilayer circuit includes a base substrate and integrated microchamber to form a microelectrode array (MEA) device. Microchannels at different levels serve as conduits towards a centrally located 2.5D/3D Microelectrode Array (MEA) for electrical stimulation/recording of electrogenic spheroids, and as inlet/outlet for injection/suction of liquids, e.g., samples or reagents. The microchamber allows for control and isolation of the cultured microenvironment, and additionally perfusion of gases, such as O2 and CO2 for electroactive responses. The device is operative with organoids under Phosphate Buffer Saline (PBS) and sample gas (Oxygen) injection.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

An optical fiber may include a cladding structure extending along a fiber length providing a hollow interior fiber region and anti-resonant (AR) elements distributed within the interior fiber region. Each of the AR elements may be formed as walled structures with walls extending along the fiber length, where at least some of the plurality of AR elements are nested to form one or more nested sets of AR elements. At least one of the nested sets of AR element may include a first AR element of the plurality of AR elements, where an interior region of the first AR element is segmented into two or more interior cavities by one or more segmentation walls extending along the fiber length. At least one of the two or more interior cavities of the first AR element may include two or more second AR elements of the plurality of AR elements.

IPC Classes  ?

• G02B 6/032 - Optical fibres with cladding with non-solid core or cladding
• G02B 6/02 - Optical fibres with cladding

Abstract

Techniques for stochastic control of at least one load is provided. Electric power generators provide alternating current (AC) to a plurality of consumer premises (CP). Each CP has one or more loads configured to be electrically powered by the AC. The stochastic control is performed at each consumer premises in a distributed manner. The stochastic control is used to maintain or increase the frequency of the AC provided by an AC electrical power distribution grid when such AC frequency falls below a nominal AC frequency of the AC electrical power distribution grid.

IPC Classes  ?

• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks
• G06F 7/58 - Random or pseudo-random number generators

Abstract

Disclosed is a method to amplified nucleic acids by polymerase chain reaction (PCR) without isolation or purification from the biological samples. All the reactions associated with reverse transcriptase qPCR or real-time qPCR are completed on a filter paper chamber using a handheld Real-time PCR device. The process requires a very small amount of sample since there is no loss of materials associated with isolation and purification steps. The amplification process is faster than a normal tube-based PCR reaction because the thin chamber makes heating and cooling process fast. This technique is applicable in the rapid detection of pathogenic viruses from body fluids, such as COVID-19 detection in saliva. The technology is valuable for quantitative detection of nucleic acids that are established markers of diseases. Novel use of a piece of filter paper to perform sample collection, storage, and conduct direct PCR amplification without any extraction of the sample will allow us to test infections and the diseases anywhere by anybody without the requirement of technical knowledge or skills.

IPC Classes  ?

• B01L 7/00 - Heating or cooling apparatusHeat insulating devices
• C12Q 1/6844 - Nucleic acid amplification reactions

Abstract

An optical fiber may include a cladding structure extending along a fiber length providing a hollow interior fiber region and anti-resonant (AR) elements distributed within the interior fiber region. Each of the AR elements may be formed as walled structures with walls extending along the fiber length, where at least some of the plurality of AR elements are nested to form one or more nested sets of AR elements. At least one of the nested sets of AR element may include a first AR element of the plurality of AR elements, where an interior region of the first AR element is segmented into two or more interior cavities by one or more segmentation walls extending along the fiber length. At least one of the two or more interior cavities of the first AR element may include two or more second AR elements of the plurality of AR elements.

IPC Classes  ?

• G02B 6/032 - Optical fibres with cladding with non-solid core or cladding

Abstract

An imaging element may include volume Bragg grating (VBG) within a material, where the material has an input face, and where the VBG is formed as a periodic distribution of curved surfaces of refractive index variation with chirped periodicity in a volume of the material. The periodic distribution of curved surfaces of refractive index variation forming the VBG may be selected to image different object planes oriented parallel to the input face onto different lateral locations of a single image plane with different wavelengths via the Bragg diffraction.

IPC Classes  ?

• G02B 5/18 - Diffracting gratings
• G02B 5/32 - Holograms used as optical elements
• G03H 1/02 - Holographic processes or apparatus using light, infrared, or ultraviolet waves for obtaining holograms or for obtaining an image from themDetails peculiar thereto Details

Abstract

An optical display system and an electronic device are disclosed. The optical display system comprises: a controllable optical image-generating display apparatus, generating circularly polarized image output; a beam scanning unit, adjusting a direction of the circularly polarized image output; an exit pupil steering apparatus, including diffractive liquid crystal lenses, each of which focuses the circularly polarized image output of one circular polarization state to a distinct focus point and let light with the other circular polarization state pass directly through; and an eye-tracking apparatus, detecting position information of a viewer's eye pupil and providing the position information to the beam scanning unit. The beam scanning unit adjusts the direction of the circularly polarized image output according to the position information, so that the circularly polarized image output is diffracted by one of the diffractive liquid crystal lenses.

IPC Classes  ?

• G02B 27/01 - Head-up displays
• G02B 3/12 - Fluid-filled or evacuated lenses
• G02B 5/18 - Diffracting gratings
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
• G02B 27/28 - Optical systems or apparatus not provided for by any of the groups , for polarising

Abstract

Described herein relates to methods of accurately determining DNA barcodes using a cylindrical nanopore system. The system and method may include the steps of leveraging the average velocity of a double-stranded DNA segment passing through a single cylindrical nanopore that may be measured through repeated scanning to accurately determine protein tag locations on the double-stranded DNA segment. As such, the system and methods may provide for the accurate calculation of a barcode for the double-stranded DNA segment based on protein tag locations without underestimation or overestimate issues. Additionally, the underlying concept and/or the system and/or the methods may be equally applicable to other multi-nanopore systems which use the dwell time and/or time of flight velocities to measure the barcodes.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G06F 17/18 - Complex mathematical operations for evaluating statistical data

Abstract

Described herein relates to an optimum, low maintenance and low-cost filtration media which may be implemented near a source water location as a pretreatment to remove tannic acid and/or humic acid (color) from dissolved natural organic matter (NOM) (i.e., tannic acid, humic acid) to impede the prompt production of disinfection by-products collectively termed trihalomethanes in drinking water treatment processes. In an embodiment, the filtration media may comprise a composition having a ratio of at least 83% sand, at most 5% clay, at most 6% ZVI and at most 6% perlite by percent volume.

IPC Classes  ?

• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• B01J 20/04 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
• B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
• B01J 20/12 - Naturally occurring clays or bleaching earth
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• C02F 101/10 - Inorganic compounds
• C02F 101/30 - Organic compounds
• C02F 101/34 - Organic compounds containing oxygen
• C02F 103/00 - Nature of the water, waste water, sewage or sludge to be treated
• C02F 103/06 - Contaminated groundwater or leachate

Abstract

An optical fiber may include a cladding structure extending along a fiber length providing a hollow interior fiber region, and anti-resonant (AR) elements formed as walled structures with walls extending along the fiber length. At least one of the AR elements surrounds an interior region and further includes one or more support structures in the interior region and formed as at least a portion of at least one of the walls, where the one or more support structures have a non-uniform thickness profile, and where the plurality AR elements is configured to guide light along the fiber length in a central portion of the hollow interior fiber region based on optical anti-resonance.

IPC Classes  ?

• G02B 6/032 - Optical fibres with cladding with non-solid core or cladding
• C03B 37/027 - Fibres composed of different sorts of glass, e.g. fibre optics
• G02B 6/024 - Optical fibres with cladding with polarisation-maintaining properties
• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers

Abstract

A method is for forming a radiation shield around an object. The method includes providing an inorganic paint pigment comprising a fluid matrix, and paint flakes carried within the fluid matrix. Each paint flake includes a common aluminum mirror layer having a first major surface and a second major surface opposing the first major surface, a first plasmonic aluminum reflector layer carried by the first major surface, and a second plasmonic aluminum reflector layer carried by the second major surface. The method also includes coating an outer surface of the object with the inorganic paint pigment.

IPC Classes  ?

• C09D 5/32 - Radiation-absorbing paints
• C09D 7/62 - Additives non-macromolecular inorganic modified by treatment with other compounds
• C09D 7/40 - Additives
• C09D 7/20 - Diluents or solvents
• C09C 1/00 - Treatment of specific inorganic materials other than fibrous fillers Preparation of carbon black
• C08K 9/02 - Ingredients treated with inorganic substances

Abstract

A system and method for wavefront correction is achieved using an adaptive optics photonic integrated circuit with monitoring per stage. The method begins with receiving a single optical data signal contained in a distorted wavefront, wherein a single optical signal is divided into a plurality of parts, each representing a unique propagation path through free space, wherein the plurality of parts of the single optical signal is received by a programmable optical processor consisting of cascaded Mach-Zehnder Interferometers (MZi) each with a first phase shifter and a second phase shifter. Next, the settings are adjusted of each of the first phase shifter and the second phase shifter until the plurality of parts of the single optical signal are combined into one output of a last MZi, wherein the settings of the first phase shifter and the setting of the second phase shifter of each MZi are controlled by independent measurements.

IPC Classes  ?

• H04B 10/112 - Line-of-sight transmission over an extended range
• H04B 10/079 - Arrangements for monitoring or testing transmission systemsArrangements for fault measurement of transmission systems using an in-service signal using measurements of the data signal
• H04B 10/61 - Coherent receivers

Abstract

Described herein relates to apparatus and method for developing a free-standing zwitterion-promoted hybrid clay film having excellent ionic conductivity, thermal stability, and/or chemical stability. As such, in an embodiment the clay film apparatus may comprise biocompatible materials, including but not limited to clay and trimethyl glycine (hereinafter “TMG”), also known as a zwitterion. Additionally, in an embodiment, the clay film apparatus may be synthesized utilizing a simple method for making a free-standing flexible, non-polymeric clay film. Moreover, in an embodiment, the prepared film's increased porosity, superior thermal and chemical stability, electrically insulating, and ionic conductivity, as compared to clay films known in the art, may make it an excellent material for energy applications as an ion-conducting membrane. The applications may include but are not limited to battery separators, electrolyte membranes in fuel cells, and solid electrolyte membranes in batteries.

IPC Classes  ?

• B01D 71/02 - Inorganic material
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/12 - Composite membranesUltra-thin membranes

Abstract

Various embodiments relate to a microserpentine including a plurality of u-bends, each having a degree of completeness (α), in which an α value of 0° corresponds to a semi-circular shape, and in which an α value of +90° corresponds to a complete circle and −90° corresponds to a straight shape. Each of the plurality of u-bends may have an α value of from about −35° to about 45°. The microserpentine may include a core coated with a conductive coating. The core may include a polymeric material. Various embodiments relate to microelectronic devices and methods of producing the same. The microelectronic devices may include but are not limited to a microelectrode array, a microelectronics packaging, an interconnect, a stretchable sensor, a wearable sensor, a wearable actuator, an in vitro sensor, an in vivo sensor, and combinations thereof.

IPC Classes  ?

• H01B 7/06 - Extensible conductors or cables, e.g. self-coiling cords
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• H05K 1/02 - Printed circuits Details

Abstract

Compositions, methods, and kits relating to substantially monodisperse, ultrasound targeted nanobubble compositions are disclosed. The nanobubble compositions comprise a hollow core containing at least one gas and a polymer shell encircling the hollow core. Methods of producing the substantially monodisperse nanobubble compositions using an ultrasound shearing-based fabrication method are disclosed. Methods of using the nanobubble compositions are also disclosed.

IPC Classes  ?

• A61K 49/22 - Echographic preparationsUltrasound imaging preparations
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 31/02 - Halogenated hydrocarbons
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation

Abstract

A method to coat active pharmaceutical ingredient (API) powders with atomically thin layers of biocompatible metal oxide films such as aluminum oxide and zinc oxide films. Metal oxide films provide a barrier that controllably dissolves and releases the active pharmaceutical ingredients (APIs) in different pH environments such as is found in the human gastrointestinal (GI) tract. Coated API powders, can be prepared using the described methods, such as 5-Aminosalicylic acid (5-ASA) powder coated with aluminum oxide and zinc oxide films.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid

Abstract

Numerous fields of basic research, medicine, and technology require an understanding of the biological composition and diversity in water samples. A common approach to acquiring such information is to collect samples ‘in the field’ and to subsequently extract nucleic acids in a laboratory for sequence analyses. A challenge to this pipeline is the preservation of the abundance and quality of the nucleic acids present in and around the organisms because, once a sample is harvested, it is no longer connected to the environment that established it. Many organisms, particularly microbes, rapidly adapt to such environmental changes and the relative abundance and quality of nucleic acids within them can change in a manner of minutes. A common methodology intended to address this problem is to filter the water to collect microorganisms on site and then to store the filters in a frozen state until they are processed. This technique creates several problems: the filter systems are expensive, require a vacuum, and are cumbersome to operate; the microbes change their metabolisms as they are filtered; freezing the samples requires substantial infrastructure at the collection site and during transport; and freezing and thawing many organisms causes their cells to break open, which releases their nucleic acids. The disclosed invention circumvents these problems by allowing microorganisms and their nucleic acids to be rapidly preserved on site using simple collection vessels, without the need for refrigeration or freezing. The methodology allows for the subsequent recovery and processing of nucleic acids for downstream molecular analyses. Although the current embodiment was developed for sea water collection, it can be also be applied to other aqueous samples

IPC Classes  ?

• A01N 1/02 - Preservation of living parts

Abstract

A patient simulation system for healthcare training is provided. The system includes one or more interchangeable shells comprising a physical anatomical model of at least a portion of a patient's body, the shell adapted to be illuminated from within the shell to provide one or more dynamic images viewable on the outer surface of the shells; wherein the system comprises one or more imaging devices enclosed within the shell and adapted to render the one or more dynamic images on an inner surface of the shell and viewable on the outer surface of the shells; one or more interface devices located about the patient shells to receive input and provide output; and one or more computing units in communication with the image units and interface devices, the computing units adapted to provide an interactive simulation for healthcare training. In other embodiments, the shell is adapted to be illuminated from outside the shell.

IPC Classes  ?

• G09B 23/34 - Anatomical models with removable parts
• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
• G09B 23/30 - Anatomical models
• G09B 23/32 - Anatomical models with moving parts
• H04N 9/31 - Projection devices for colour picture display
• H04N 23/698 - Control of cameras or camera modules for achieving an enlarged field of view, e.g. panoramic image capture

Abstract

This invention relates to a self-supervised privacy preservation action recognition system leveraging a learnable transformation anonymization function. The system is designed to process videos by removing spatial cues to protect privacy while retaining critical information for action recognition. The anonymization function, based on an encoder-decoder model, undergoes iterative training on a dataset to optimize the balance between obscuring privacy-sensitive information and preserving capability of recognizing actions. This training involves freezing and adjusting the weights of an action recognition branch and a self-supervised privacy removal branch to refine the model's effectiveness. The outcome is an anonymized video with minimized privacy information leakage, suitable for action analysis without privacy labels. Additional functionalities include frame sampling for enhanced privacy evaluation, data augmentation for model robustness, and a minimax optimization protocol ensuring optimal action recognition accuracy alongside privacy preservation.

IPC Classes  ?

• G06V 20/52 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects
• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 20/40 - ScenesScene-specific elements in video content
• G06V 40/20 - Movements or behaviour, e.g. gesture recognition

Abstract

Described herein relates to system and method for detecting an abnormal presence within at least one dataset. In an embodiment, the dataset may comprise 1D signals, and/or multidimensional signals (e.g., images). The multi-field data analysis system (hereinafter “system”) may be configured to detect at least one type of abnormality that may not be detected visually otherwise (e.g., analysis by an expert). In addition, the system may be configured to detect the size and/or shape of the abnormality. In this embodiment, the system may also retain the physical location (spatial information) of the abnormality. As such, the system may optimize computation and/or implementation due to the system's ability to project the data on any appropriate domain (e.g., transform domains). Moreover, the system may be configured to search for abnormalities and/or particular characteristics any biometric signal known in the art.

IPC Classes  ?

• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation

Abstract

A system for use in determining parking spot allocation. The system includes a host vehicle parked in a host parking spot. The host vehicle includes a transceiver configured for vehicle-to-vehicle communication, and a control unit configured to determine the host vehicle is ready to depart the host parking spot, receive, via the transceiver, a first signal from at least one client vehicle, wherein the first signal indicates the at least one client vehicle is searching for a parking spot, allocate the host parking spot to a first client vehicle of the at least one client vehicle; and transmit, via the transceiver, a second signal to the first client vehicle, wherein the second signal notifies the first client vehicle that the host parking spot has been allocated to the first client vehicle, and provides location data associated with the host parking spot to the first client vehicle.

IPC Classes  ?

• G08G 1/14 - Traffic control systems for road vehicles indicating individual free spaces in parking areas
• H04W 4/44 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P] for communication between vehicles and infrastructures, e.g. vehicle-to-cloud [V2C] or vehicle-to-home [V2H]

Abstract

Provided herein is a system for use in determining right-of-way. The system includes a host vehicle at or approaching an intersection, and the host vehicle includes a transceiver configured for vehicle-to-vehicle communication and a control unit. The control unit is configured to receive a local map of an area surrounding the intersection; receive, via the transceiver, a first signal from at least one client vehicle, wherein the first signal indicates the at least one client vehicle is at or approaching the intersection; determine, based upon a set of rules, that the host vehicle is an arbitrator, wherein the arbitrator assigns a priority value for right-of-way to each vehicle at or approaching the intersection; and transmit, via the transceiver, a second signal to the at least one client vehicle, wherein the second signal includes the assigned priority values for each vehicle at or approaching the intersection.

IPC Classes  ?

• G08G 1/16 - Anti-collision systems
• H04W 4/46 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P] for vehicle-to-vehicle communication [V2V]

Abstract

A nickel-free and cobalt-free cathode for a lithium (Li) battery is provided. The lithium manganese composite oxide material of the cathode has a sloping discharge voltage profile between 3V to 4 V. The material comprises multiple crystal structures with R3-m, C2/m, and Pmnm space groups, and is characterized to maintain a high capacity when these phases are in a specific ratio.

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/485 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of mixed oxides or hydroxides for inserting or intercalating light metals, e.g. LiTi2O4 or LiTi2OxFy
• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy

Abstract

An optical receiver may include multiple photodetectors connected in serial and an amplifier connected to the photodetectors, where the amplifier is configured to amplify an electrical signal generated by the photodetectors in response to illumination. The receiver may further include one or more optical elements to receive signal light and direct the signal light to a subset of the plurality of photodetectors. The receiver may further include an illumination source to illuminate the plurality of photodetectors with flood illumination during operation. An optical modulator may include multiple modulators connected in serial and driven by a common voltage driver.

IPC Classes  ?

• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G01J 1/44 - Electric circuits
• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
• G02F 1/015 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on semiconductor elements having potential barriers, e.g. having a PN or PIN junction

Abstract

Anti-malarial compounds are disclosed for administration to subjects infected or at risk of being infected with a Plasmodium sp.

IPC Classes  ?

• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 33/06 - Antimalarials

Abstract

A light source may include an array of grating-coupled semiconductor optical amplifiers (GC-SOAs) arranged along a surface of a substrate, where the array of GC-SOAs receive seed light from a common seed source, and where the array of GC-SOAs provide an array of SOA output beams associated with amplification of the seed light at a non-zero angle from the surface of the substrate. A light source may further include one or more phase shifters configured to provide that the SOA output beams are phase-locked.

IPC Classes  ?

• H01S 5/40 - Arrangement of two or more semiconductor lasers, not provided for in groups
• H01S 5/04 - Processes or apparatus for excitation, e.g. pumping
• H01S 5/068 - Stabilisation of laser output parameters
• H01S 5/0683 - Stabilisation of laser output parameters by monitoring the optical output parameters

Abstract

A multiplication unit, such as a photonic multiplication unit, for multiplication of a floating point number is claimed. A first signal is produced representing an exponent of a floating point number mapped onto a frequency of a harmonic wave. A second signal is produced representing a significant of the floating point number mapped onto an amplitude of the harmonic wave to produce a floating point number. There are numerous examples of how the floating point number may be used, such as displayed, stored in a fixed, non-transitory, storage medium for later retrieval, used in a mathematical operation using cascade modulation, used in a mathematical operation using interference, used in a mathematical operation using interference with a comb filter, used in a mathematical operation using cascade operation with summation. The multiplication unit includes is extendable to a multiplication unit for vector, matrix or tensor multiplication using interference or o beam combiner.

IPC Classes  ?

• G06F 7/487 - MultiplyingDividing

Abstract

A system and method for evaluating Boolean functions using in-memory computing comprising a plurality of programmed non-volatile memory devices synthesized in a crossbar design. The evaluation phase of a given Boolean function using the programmed non-volatile memory devices is accomplished using READ operations only.

IPC Classes  ?

• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

The system extracts water from lunar regolith and includes a regolith intake having a digging bucket that collects lunar regolith soil and a gravel separator that separates and discharges gravel and passes a mixture of ice-regolith powder having ice grains that are about 10-100 microns along the conveyor. A pneumatic separator receives the ice-regolith powder and pneumatically splits the ice-regolith powder into streams of different sized lithic fragments and ice particles per the ratio of inertial force and aerodynamic drag force of the lithic fragments and ice particles. Each split stream may include a magnetic separator that separates further the magnetic and paramagnetic lithic fragments from ice particles to discharge up to 80 percent of lithic fragments to slag.

IPC Classes  ?

• E21C 51/00 - Apparatus for, or methods of, winning materials from extraterrestrial sources
• B03C 1/30 - Combinations with other devices, not otherwise provided for
• B03C 7/02 - Separators
• B04C 9/00 - Combinations with other devices, e.g. fans
• B64G 4/00 - Tools specially adapted for use in space
• B64G 5/00 - Ground equipment for vehicles, e.g. starting towers, fuelling arrangements

Abstract

CNN-based methods for cross-view image geo-localization rely on polar transform and fail to model global correlation. A pure transformer-based approach (TransGeo) is described to address these limitations from a different perspective. TransGeo takes full advantage of the strengths of the transformer related to global information modeling and explicit position information encoding. The claimed invention further leverages transformer input's flexibility and discloses an attention-guided non-uniform cropping method so that uninformative image patches are removed with a negligible drop in performance to reduce computation cost. The saved computation can be reallocated to increase resolution only for informative patches, resulting in performance improvement with no additional computation cost. This “attend and zoom-in” strategy is highly similar to human behavior when observing images. Remarkably, TransGeo achieves state-of-the-art results on both urban and rural datasets, with significantly less computation cost than CNN-based methods. It does not rely on polar transform and provides faster methods.

IPC Classes  ?

• G06T 3/4053 - Scaling of whole images or parts thereof, e.g. expanding or contracting based on super-resolution, i.e. the output image resolution being higher than the sensor resolution
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects

Abstract

Here discloses a method for duplicating a hologram and a hologram optical element. The method comprises: preparing a master with a master hologram; preparing a sample with coated photoalignment material layer above the master; and irradiating a recording light through the sample to the master, so that at least one portion of the recording light is reflected by the master as an object light carrying the master hologram information, and so that the object light and the recording light are interfered at the photoalignment material layer to produce a duplicated hologram in the photoalignment material layer.

IPC Classes  ?

• G03H 1/20 - Copying holograms by holographic means
• G02B 5/32 - Holograms used as optical elements
• G03H 1/02 - Holographic processes or apparatus using light, infrared, or ultraviolet waves for obtaining holograms or for obtaining an image from themDetails peculiar thereto Details
• G03H 1/04 - Processes or apparatus for producing holograms

Abstract

A system may include a first light source configured to generate a first light beam, where the first light beam is a pulsed light beam, where the first light beam is guided as a single transverse mode beam. A system may include a second light source configured to generate a second light beam, where the second light beam is a continuous-wave light beam. A system may include a hollow core optical fiber configured to propagate the first and second light beams. A system may include one or more optical elements to couple the first and second beams into the hollow core fiber.

IPC Classes  ?

• G02B 6/032 - Optical fibres with cladding with non-solid core or cladding
• G02B 6/26 - Optical coupling means
• H04B 10/2507 - Arrangements specific to fibre transmission for the reduction or elimination of distortion or dispersion
• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
• A61N 5/06 - Radiation therapy using light

Abstract

Various embodiments relate to a method for producing a metal-organic framework (MOF) having a desired redox conductivity and including redox-active linkers, having ω-alkyl-ferrocene groups, via de novo solvothermal synthesis. Various embodiments relate to a metal-organic framework (MOF) linker comprising an ω-alkyl-ferrocene group. Various embodiments relate to a metal-organic framework (MOF), having a first plurality of redox-active linkers, each having an ω-alkyl-ferrocene group. The MOF according to various embodiments, may further have one or more redox-inactive linkers. Various embodiments relate to materials, apparatuses, and components that include the MOF according to various embodiments. For example, various embodiments relate to thin-films, bulk powders, or electrodes.

IPC Classes  ?

• C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
• C25B 11/048 - Organic compounds

Abstract

Here discloses an optical display system and an electronics device. The optical display system comprises: image-generating display; controllable polarization rotator module, which receives light from the image-generating display and outputs the light into polarized light with a first polarization and/or a second polarization under control; a first reflective lens, which reflects the polarized light with a first polarization to a pupil of an observer; and a second reflective lens, which reflects the polarized light with a second polarization to the pupil, wherein the first reflective lens and the second reflective lens have different optical powers to produce image planes at different depths.

IPC Classes  ?

• G02B 27/01 - Head-up displays
• G02B 27/12 - Beam splitting or combining systems operating by refraction only
• G02B 27/28 - Optical systems or apparatus not provided for by any of the groups , for polarising

Abstract

A ceria heterostructure may include one or more base materials and one or more ceria surface structures at least partially surrounding the one or more base materials, where defect states of the one or more ceria surface structures are reversibly controllable by controlling a stress on the one or more surface structures that is at least partially induced by the one or more base materials.

IPC Classes  ?

• C23C 16/40 - Oxides
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells

Abstract

A sensor may include one or more photonic lanterns, each including a waveguide structure with a single input waveguide at an input end and two or more output waveguides at an output end, where the two or more output waveguides of each of the one or more photonic lanterns are optically decoupled. A distribution of intensities of light exiting two or more output waveguides of each of the one or more photonic lanterns may correspond to a modal decomposition of input light coupled into the input waveguide of the corresponding one of the one or more photonic lanterns. The sensor may further include one or more spectrometers coupled to the two or more output waveguides of the one or more photonic lanterns to provide a wavelength-resolved modal decomposition of the input light.

IPC Classes  ?

• G01J 3/28 - Investigating the spectrum
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/14 - Generating the spectrumMonochromators using refracting elements, e.g. prism

Abstract

An optical imaging system and an imaging device are disclosed. The optical imaging system includes: a display assembly, which outputs lights of an image; a lens assembly, which enlarges the image; a polarization converter, wherein the polarization converter is a frequency-dependent polarization converter, which can convert the lights of a first frequency to a first polarization and convert the lights of a second frequency to a second polarization; and an aberration-correcting optical assembly, which is a polarization-dependent planar optics assembly.

IPC Classes  ?

• G02B 27/01 - Head-up displays
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
• G02B 27/09 - Beam shaping, e.g. changing the cross-sectioned area, not otherwise provided for
• G02B 27/28 - Optical systems or apparatus not provided for by any of the groups , for polarising
• G02B 27/42 - Diffraction optics
• G02B 27/44 - Grating systemsZone plate systems

Abstract

A method for manufacturing a color-changing product using an electrical connectorization system including an ultrasonic welder includes providing a fabric to the electrical connectorization system where the fabric includes a plurality of color-changing fibers, providing a connection bus to the electrical connectorization system, and operating the electrical connectorization system to move the fabric and the connection bus into engagement with the ultrasonic welder to generate one or more welds between the connection bus and at least a subset of the plurality of color-changing fibers as the fabric and the connection bus pass the ultrasonic welder.

IPC Classes  ?

• D03D 1/00 - Woven fabrics designed to make specified articles

Abstract

A hollow core fiber (HCF) may include a solid tubular cladding structure extending in a longitudinal direction along a length of the HCF and one or more antiresonant (AR)structures extending in the longitudinal direction along the length of the HCF and located in an interior region of the cladding structure, where the one or more AR structures form a central hollow region providing a core region for guiding light. The HCF may further include a low-index coating at least partially surrounding the cladding structure, wherein a refractive index of the low-index coating is lower than a refractive index of the cladding structure to provide guiding of leakage light, where the leakage light includes at least light that decouples from the hollow central core.

IPC Classes  ?

• G02B 6/02 - Optical fibres with cladding
• C03B 37/027 - Fibres composed of different sorts of glass, e.g. fibre optics

Abstract

A prediction system may train a neural network model to analyze data to predict sentiments associated with the data and a measure of incompleteness of the data. The prediction system may obtain communication data regarding a communication session between a first device and a second device. The communication data is obtained via a network. The prediction system may provide the communication data as an input to the trained neural network model. The prediction system may determine, using the trained neural network model, a first set of sentiments associated with the first device and a second set of sentiments associated with the second device. The prediction system may determine, using the trained neural network model, a measure of incompleteness of the communication data based on the first set of sentiments and the second set of sentiments. The prediction system may perform an action based on the measure of incompleteness.

IPC Classes  ?

• G06F 40/242 - Dictionaries
• G06F 40/205 - Parsing

Abstract

A system can include a beamsplitter configured to be in optical communication with an optical input source configured to generate one or more input optical signals. The beamsplitter can be configured to split the one or more input optical signals into one or more seed optical signals configured to propagate along a first optical path, and one or more pump optical signals configured to propagate along a second optical path. The system can include a frequency divider in optical communication with the beamsplitter to receive the one or more seed optical signals. The frequency divider can be configured to divide optical frequencies of the one or more seed optical signals in half to provide one or more subharmonic seed optical signals. The system can include a beam combiner in optical communication with the frequency divider to receive the one or more subharmonic seed optical signals, and with the beamsplitter to receive the one or more pump optical signals. The beam combiner can be configured to combine at least one of the one or more pump optical signals and at least one of the one or more subharmonic seed optical signals to provide a combined optical signal. The system can include a nonlinear material in optical communication with the beam combiner to receive the combined optical signal. The nonlinear material can be configured to provide optical parametric amplification of the at least one of the one or more subharmonic seed optical signals of the combined optical signal.

IPC Classes  ?

• G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves

Abstract

This invention relates to a biodegradable hydrophobic or omniphobic coating with tailorable properties for various applications. The technology's hydrophobic modifications, surface functionalization, and surface roughness modifications enable low contact angle hysteresis for easy roll-off and self-cleaning properties. The composite is based on polymer substrate(s) or functionalized polymer substrate(s), filler(s), inorganic(s), binder(s), Lycopodium, or a combination of materials. The Lycopodium may be functionalized with suitable end groups for better adhesion or to impart beneficial properties. The polymer(s) and other constituents may be deposited on the substrate by various methods including spin coating, dip coating, spray coating, sputter coating, electrospinning, solvent casting, or extrusion. Binders and chemicals are incorporated in suitable chronology with or without the solvents of choice.

IPC Classes  ?

• C08J 7/04 - Coating
• C09D 5/16 - Anti-fouling paintsUnderwater paints
• C09D 197/02 - Lignocellulosic material, e.g. wood, straw or bagasse
• C09D 201/00 - Coating compositions based on unspecified macromolecular compounds

Abstract

Described herein relates to a self-supervised reinforced learning (hereinafter “SSRL”) system for question-and-answer query systems that may include one or more initial steps to prime a neural network to prevent an agent from prematurely selecting an early path and method thereof. The SSRL method may also provide the agent with a lead for queries with a large action space, such that at least one existing reinforced learning system may be improved (e.g., accuracy). Additionally, to scale to larger datasets in which label generation for each training sample is infeasible, the SSRL system may include one or more steps of pretraining the dataset(s) with partial labels, which may be generated from a subset of a whole knowledge graph.

IPC Classes  ?

• G06N 5/02 - Knowledge representationSymbolic representation
• G06N 3/092 - Reinforcement learning

Abstract

A fastener gun or nail gun utilizes a propellant cartridge having a centerfire primer made from thermite. The thermite is made from alternating layers of metal oxide and reducing metal, and includes one or more layers of carbide-containing ceramic. The primer ignites a propellant which may be a conventional single base or double base smokeless powder, or which may be thermite having a structure similar to the thermite of the primer. The primer may be initiated mechanically or electrically. The fastener gun is capable of applying a level of force similar to the force applied by conventional propellant cartridges, while avoiding inhalation of lead particles by the operator of the fastener gun.

IPC Classes  ?

• B25C 1/16 - Cartridges specially adapted for impact toolsCartridge-and-nail units
• C06C 9/00 - Chemical contact ignitersChemical lighters
• F42B 5/16 - Cartridges, i.e. cases with propellant charge and missile characterised by composition or physical dimensions or form of propellant charge or powder