Abstract

A thermally insulating apparatus comprises a first material (10) configured to at least partially enclose an article (30), such as a flight data recorder and/or cockpit voice recorder or a part thereof, the first material (10) comprising or consisting of a metal fluoride hydrate; and a second material (20) configured to at least partially enclose the first material (10), the second material (20) comprising or consisting of an inorganic scrubbing agent.

IPC Classes  ?

• C09K 5/18 - Non-reversible chemical reactions
• H01L 23/42 - Fillings or auxiliary members in containers selected or arranged to facilitate heating or cooling

Goods & Services

Downloadable content in the field of finance; downloadable content relating to cryptocurrency-related risks; downloadable content relating to blockchain systems; downloadable electronic publications in the field of finance; downloadable electronic publications relating to cryptocurrency-related risks; downloadable electronic publications relating to blockchain systems; interactive electronic publications; downloadable electronic reports in the field of finance; downloadable electronic reports relating to cryptocurrency-related risks; downloadable electronic reports relating to blockchain systems; interactive downloadable software; downloadable software for finance; downloadable financial management software; downloadable software for producing financial models; downloadable software for quantifying the degree of decentralization across various blockchain systems; downloadable software for managing cryptocurrency-related risks; downloadable risk detection software; databases; interactive databases. Financial, monetary and banking services; computerised financial data monitoring and analysis; computerised financial information services; financial analysis and research services; financial data analysis; financial due diligence services; financial economic analysis; financial forecasting; preparation of financial reports; financial studies; investment risk assessment services; financial risk management; financial research in the field of risk management; financial consultancy in the field of risk management; economic financial research services; research and analysis relating to financial transactions via blockchain; research and analysis relating to the financial trading of cryptocurrency; research and analysis relating to the electronic transfer of cryptocurrency; research and analysis relating to the financial exchange of crypto assets; financial evaluation; financial appraisals; providing and updating financial index; information, advice and consultancy in relation to the aforesaid. Scientific research and analysis; preparation of technical reports in the field of finance; preparation of technical reports relating to blockchain systems; preparation of technical reports relating to cryptocurrency-related risks; technical research services in the field of finance and cryptocurrency; research services relating to blockchain technology; providing online non-downloadable software; providing online non-downloadable software for finance; providing online non-downloadable financial management software; providing online non-downloadable software for producing financial models; providing online non-downloadable software for quantifying the degree of decentralization across various blockchain systems; providing online non downloadable software for managing cryptocurrency-related risks; providing online non-downloadable risk detection software; design and development of software tools for finance; design and development of software tools for quantifying the degree of decentralization across various blockchain systems; design and development of software tools for managing cryptocurrency-related risks; design and development of computer codes; design of models; design of mathematical models; design of computer-simulated models; technical development of frameworks and tools for evaluating blockchain system decentralisation across various layers; information, advice and consultancy in relation to the aforesaid.

Abstract

An imaging apparatus for collecting and imaging a sample inside a vessel comprising: a first surface comprising or configured to receive a first optical element; a light source housing for a light source; a moveable spacer secured at a distal end of the light source housing by a resilient membrane and moveable relative to the distal end of the light source housing, wherein the moveable spacer comprises a second surface comprising or configured to receive a second optical element; a mechanism for controllably moving said moveable spacer from a retracted position to a protruding position relative to the distal end of the light source housing, wherein the movable spacer is biased against movement into the protruding position by the resilient membrane, wherein the first surface and/or the second surface of the moveable spacer comprise one or more interfacing features configured to form an at least partially closed sample chamber for imaging, wherein the at least partially closed sample chamber is defined, at least in part, by the first and second optical elements and/or at least part of the interfacing features.

IPC Classes  ?

• G01N 15/075 - Investigating concentration of particle suspensions by optical means
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 21/03 - Cuvette constructions
• G02B 21/00 - Microscopes
• G02B 21/24 - Base structure
• G02B 21/34 - Microscope slides, e.g. mounting specimens on microscope slides
• G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials

Abstract

Disclosed is a construct for use in a method of transcriptional activation of a complex genomic locus. The construct comprises a single guide RNA (sgRNA) binding a regulatory element of the said complex genomic locus, and a deactivated Cas. The construct may be introduced into cells including the genomic locus of interest in order to activate the regulatory element to transcribe multiple transcripts within said complex genomic locus.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/86 - Viral vectors

Abstract

A sampling apparatus (100) comprises a probe (220), the probe comprising a first lumen (222) configured to dispense a first fluid at a distal end (230) thereof; a second lumen (223) configured to aspire the first fluid at a distal end (230) thereof, wherein a distal end of the first lumen is adjacent a distal end of the second lumen, wherein the sampling apparatus (100) is configured to dispense the first fluid via the first lumen (322) and to aspirate the first fluid via the second lumen (323) simultaneously.

IPC Classes  ?

• A61B 10/04 - Endoscopic instruments, e.g. catheter-type instruments
• A61B 1/015 - Control of fluid supply or evacuation
• A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements

Abstract

The disclosure provides for optimized therapeutic MECP2 polynucleotide constructs utilized for replacing or compensating for the loss of MeCP2 function in patients with Rett Syndrome. Suitably, the disclosure provides gene therapy cassettes to enable better regulatory control of the MeCP2 protein, including tunable systems that allow MECP2 gene therapy to be expressed at a desired moderate level and demonstrate expression of the vector-derived transgene within a window that alleviates the disease-causing genetic deficiency without producing undesired side effects including overexpression toxicity.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/86 - Viral vectors

Abstract

A heat exchange device (10) for use in a heat exchange apparatus (12) configured to transfer heat from and/or to a water source comprises a support arrangement (14) and a pipe arrangement (16). The pipe arrangement (16) is configured and/or operable to convey a working fluid of the heat exchange apparatus (12). The pipe arrangement (16) is disposed on or operatively associated with the support arrangement such that the pipe arrangement (16) defines one or more conical spirals. The pipe arrangement (16) may be constructed from a thin-walled plastic material. The support arrangement (14) comprises one or more support arms (38), at least one of which is curved or substantially curved. The pipe arrangement (16) may be configured and/or operable such that the heat exchange device (10) self-bleeds air.

IPC Classes  ?

• F28D 7/02 - Heat-exchange apparatus having stationary tubular conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits being helically coiled
• F28D 7/04 - Heat-exchange apparatus having stationary tubular conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits being spirally coiled
• F28F 9/013 - Auxiliary supports for elements for tubes or tube-assemblies
• F28F 21/06 - Constructions of heat-exchange apparatus characterised by the selection of particular materials of plastics material

Abstract

KomagataellaKomagataellaKomagataellaKomagataellaKomagataellaKomagataella Komagataella species.

IPC Classes  ?

• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Goods & Services

Computer software; downloadable computer software; cloud computing software; downloadable machine learning software; downloadable artificial intelligence computer software; downloadable generative artificial intelligence computer software; downloadable computer software for generating and creating text, videos and images; downloadable computer software for machine-learning based language and speech processing; downloadable computer software for the artificial production of human speech and text; downloadable computer software for natural language processing, generation, understanding and analysis; downloadable computer chatbot software for simulating conversations; machine learning downloadable software; mobile application software; mobile application software for generating and creating text, videos and images; mobile application software for machine-learning based language and speech processing; mobile application software for the artificial production of human speech and text mobile application software for natural language processing, generation, understanding and analysis; mobile application chatbot software for simulating conversations; parts, fittings and accessories for the aforementioned goods. Software as a Service [SaaS]; Platform as a Service [PaaS]; providing online non-downloadable computer software; providing online non-downloadable artificial intelligence computer software; providing online non-downloadable generative artificial intelligence computer software; providing online non-downloadable computer software for generating and creating text, videos and images; providing online non-downloadable computer software for machine-learning based language and speech processing; providing online non-downloadable computer software for the artificial production of human speech and text; providing online non-downloadable computer software for natural language processing, generation, understanding and analysis; providing online non-downloadable computer chatbot software for simulating conversations; research, design and development of computer programs and software; research and development services in the field of artificial intelligence; research and development services in the field of large language models [LLM]; cloud computing services; consultancy services in the field of artificial intelligence software and cloud computing; Design and development of operating software for cloud computing networks; rental of operating software for accessing and using a cloud computing network; installation, repair and maintenance of computer software; information, advice and consultancy for the aforementioned services.

Abstract

A lateral flow immunoassay 10 comprises a sample-receiving portion 20 configured to receive a sample; SERS-active particles configured to bind to cytokeratin-18 (K18) in the sample; and a test portion 40 configured to immobilise SERS-active particles that have bound to K18.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 21/65 - Raman scattering
• G01N 33/558 - ImmunoassayBiospecific binding assayMaterials therefor using diffusion or migration of antigen or antibody

Abstract

The disclosure relates to a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, wherein: R1 is selected from a group consisting of alkyl, cycloalkyl, alkenyl, cycloalkenyl and alkynyl; R2 is selected from a group consisting of H, halo, OR11, NHR11, alkyl, alkenyl and alkynyl; R3 is selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, halo, aryloxy, NHCO2R4, NHCONR5R6, NHCOR7, NH-alkyl, NH-alkenyl, NH(CH2)n-aryl, (CH2)p-heteroaryl, (CH2)qCO2R8, (CH2)qCOR9 and NHSO2R10, wherein each alkyl, alkenyl, aryl or heteroaryl moiety in the aforementioned list is optionally further substituted by one or more groups selected from alkyl, halo, OH, NH2, alkoxy, aryloxy, alkylamino, arylamino, carboxyl and carboxamide; R4 to R11 are each independently selected from a group consisting of alkyl, alkenyl and aryl; and n is selected from a group consisting of 0, 1, 2, 3, 4, 5 and 6, p is selected from a group consisting of 0, 1, 2, 3, 4, 5 and 6, q is selected from a group consisting of 0, 1, 2, 3, 4, 5 and 6, and r is selected from a group consisting of 0, 1, 2, 3, 4, 5 and 6. The disclosure also relates to pharmaceutical compositions, therapeutic uses and process for preparing the compound of the disclosure.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 35/00 - Antineoplastic agents

Abstract

A system for monitoring user gestures or other movement or state, comprises: at least one sensor configured to perform measurements of muscle, nerve and/or brain activity of a user; a processing resource configured to: receive measurements from the at least one sensor; provide inputs comprising a set of features based on the measurements to a trained machine learning model, wherein the machine learning model is trained to determine distance in a latent space that is of lower dimensionality than a dimensionality of the set of input features, and the distance represents closeness of a position to a centroid or other position in the latent space that corresponds to a classification as a respective one a plurality of different gestures on which the machine learning model is trained, provide an output to the user representing or determined from the determined distance, thereby representing similarity between the gesture or other movement or state by the user and one or more gestures or other movements or states of interest, wherein the output varies as the muscle, nerve and/or brain activity of the user varies.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample.

IPC Classes  ?

• G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A microfluidic device comprising: a microfluidic module comprising: a plurality of fluidic paths between an input and an output; and a plurality of restrictions, wherein each restriction is provided on a respective fluidic path of the plurality of fluidic paths, wherein each restriction is configured to trap or at least restrict movement of one or more objects, for example, one or more tissue and/or multicellular objects, in a fluid introduced along its respective fluidic path at a respective sensing region; and at least one further fluidic path between the input and a further output, wherein the at least one further fluidic path is in fluid communication with the plurality of restrictions and wherein the further fluidic path comprises a delivery portion between the input and the plurality of restrictions to allow delivery of a further fluid to the trapped and/or restricted one or more objects and an output portion to allow removal of the further fluid from the further output; wherein the device further comprises: an electronic sensing module comprising: at least one sensing element arranged to sense one or more signals from the respective sensing regions of the plurality of restrictions.

IPC Classes  ?

• B01L 3/50 -

Abstract

Disclosed are methods of achieving viral resistance in animals and modified protein sequences which exhibit reduced polymerase activity.

IPC Classes  ?

• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A01K 67/0275 - Genetically modified vertebrates, e.g. transgenic
• C07K 14/465 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from birds

Goods & Services

Downloadable content in the field of finance; downloadable content relating to cryptocurrency-related risks; downloadable content relating to blockchain systems; downloadable electronic publications in the field of finance; downloadable electronic publications relating to cryptocurrency-related risks; downloadable electronic publications relating to blockchain systems; interactive electronic publications; downloadable electronic reports in the field of finance; downloadable electronic reports relating to cryptocurrency-related risks; downloadable electronic reports relating to blockchain systems; interactive downloadable software; downloadable software for finance; downloadable financial management software; downloadable software for producing financial models; downloadable software for quantifying the degree of decentralization across various blockchain systems; downloadable software for managing cryptocurrency-related risks; downloadable risk detection software; databases; interactive databases. Financial, monetary and banking services; computerised financial data monitoring and analysis; computerised financial information services; financial analysis and research services; financial data analysis; financial due diligence services; financial economic analysis; financial forecasting; preparation of financial reports; financial studies; investment risk assessment services; financial risk management; financial research in the field of risk management; financial consultancy in the field of risk management; economic financial research services; research and analysis relating to financial transactions via blockchain; research and analysis relating to the financial trading of cryptocurrency; research and analysis relating to the electronic transfer of cryptocurrency; research and analysis relating to the financial exchange of crypto assets; financial evaluation; financial appraisals; providing and updating financial index; information, advice and consultancy in relation to the aforesaid. Scientific research and analysis; preparation of technical reports in the field of finance; preparation of technical reports relating to blockchain systems; preparation of technical reports relating to cryptocurrency-related risks; technical research services in the field of finance and cryptocurrency; research services relating to blockchain technology; providing online non-downloadable software; providing online non-downloadable software for finance; providing online non-downloadable financial management software; providing online non-downloadable software for producing financial models; providing online non-downloadable software for quantifying the degree of decentralization across various blockchain systems; providing online non downloadable software for managing cryptocurrency-related risks; providing online non-downloadable risk detection software; design and development of software tools for finance; design and development of software tools for quantifying the degree of decentralization across various blockchain systems; design and development of software tools for managing cryptocurrency-related risks; design and development of computer codes; design of models; design of mathematical models; design of computer-simulated models; technical development of frameworks and tools for evaluating blockchain system decentralisation across various layers; information, advice and consultancy in relation to the aforesaid.

Abstract

Disclosed are compounds which modulates the function, activity and/or expression of a swine leucocyte antigen complex II (SLA II) gene and/or a SLA II protein, for use in medicine, for use as medicaments or for use in treating or preventing ASF or an ASFV infection. The disclosure also provides the use the SLA-DMA, SLA-DMB, RFXANK, RFXAP 5 and CIITA genes for achieving ASFV resistance.

IPC Classes  ?

• A01K 67/0275 - Genetically modified vertebrates, e.g. transgenic
• C07K 14/74 - Major histocompatibility complex [MHC]

Abstract

A method of identifying stable peptides from a protein, said method comprising: obtaining a peptide from a protein; comparing a solvent-accessible surface area (SASA) of the peptide with a SASA of a corresponding peptide region within the protein; using a result of the comparison to determine whether or not the peptide is structurally stable relative to the corresponding peptide region within the protein. Also disclosed is use of the method to identify stable immunogenic epitopes of SARS-CoV-2, and methods of detecting an antibody response.

IPC Classes  ?

• G16B 15/20 - Protein or domain folding
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction

Abstract

There is provided a computer-implemented method 70 of obtaining reflection properties of a subsurface region. The method 70 comprises determining 72 an initial dictionary constructed from a starting pulse. The method 70 further comprises inverting 74 seismic data of a subsurface region using the initial dictionary to obtain a model of subsurface reflectivities, and the method further comprises updating 76 the initial dictionary based on the model of subsurface reflectivities according to set criteria to generate a learned dictionary; and repeating the inverting 76 of seismic data using the learned dictionary until a convergence criteria is met.

IPC Classes  ?

• G01V 1/28 - Processing seismic data, e.g. for interpretation or for event detection
• E21B 41/00 - Equipment or details not covered by groups
• G01V 1/30 - Analysis

Abstract

The present disclosure relates to the development of novel constructs that are specifically cleaved by fibroblast activation protein-α (FAP) and uses thereof in assays for detecting FAP. Particular constructs include a fluorescence resonance energy transfer (FRET) probe comprising a fluorescent moiety and a quencher moiety attached to a FAP cleavable peptide sequence and optionally including a solubilising moiety, which may be a polyethylene glycol (PEG) derivative.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.

IPC Classes  ?

• C07D 215/48 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• A61K 51/04 - Organic compounds

Abstract

According to the present disclosure, there is provided an endoscopic fibre having a proximal end and a distal end, comprising a plurality of cores wherein one or more of the cores comprise excitation core(s) and one or more of the cores comprise collection core(s); wherein the excitation core or cores each comprises a solid core; wherein the collection core or cores each comprises a respective solid core with a refractive index that is different to a refractive index of the excitation core or cores; wherein the excitation core or cores are configured to transmit an optical excitation signal from the proximal end to a target region at or near the distal end; and wherein the collection core or cores are configured to transmit an optical detection signal from the target region at or near the distal end to the proximal end; and the difference in refractive index between excitation core(s) and the collection core(s) is such that cross-talk between mode(s) in the excitation core(s) and mode(s) in the collection core(s) is reduced or eliminated. There is also provided a fibre connector configured to connect to the fibre, a detection system comprising a laser source or other excitation light source connected to the excitation core(s) of the fibre, and a method of performing Raman spectroscopy comprising transmitting an excitation signal to a target region via the excitation core(s) of a fibre.

IPC Classes  ?

• G02B 6/02 - Optical fibres with cladding
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present disclosure relates to methods and kits for detecting levels of androgens, androgen precursors and androgen metabolites. In particular, the present disclosure relates to methods and kits for diagnosing and/or prognosing endometriosis based on the levels of these androgens, androgen precursors and androgen metabolites.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/74 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving hormones

Abstract

eySBSB eycondcondSBSB. • the method is based on actuating adsorption and desorption in the sorption chamber via a pressure swing, rather than a temperature swing.

IPC Classes  ?

• C02F 1/16 - Treatment of water, waste water, or sewage by heating by distillation or evaporation using waste heat from other processes
• B01D 1/00 - Evaporating
• B01D 3/00 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
• B01D 3/42 - RegulationControl
• C02F 103/08 - Seawater, e.g. for desalination
• C02F 1/00 - Treatment of water, waste water, or sewage

Abstract

The disclosure provides methods, compounds (molecules) and/or compositions for the treatment and/or prevention of diseases and/or conditions caused or contributed to by TAR DNA-binding protein 43 (TDP-43) dependent mis-splicing of its downstream target genes.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides

Abstract

The present invention relates to methods of modulating reprogramming, comprising increasing, enhancing and/or promoting the activity of peptidylarginine deiminase 4 (PADI4) enzyme, such as wherein the reprogramming of a somatic cell to a pluripotent-like state is increased, enhanced and/or promoted. The invention further relates to activators of PADI4, in particular activators which allosterically bind to PADI4, as well as their use in methods of reprogramming somatic cells and pharmaceutical compositions comprising said activators. Also provided is the pharmaceutical composition for use in treatment, rejuvenation, regeneration and repair.

IPC Classes  ?

• C12N 5/074 - Adult stem cells
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Abstract

The present disclosure relates to composite materials comprising a recycled polymer material and a waste glass fiber material, and methods of manufacturing such composite materials. The described materials have been found to show a number of good mechanical properties.

IPC Classes  ?

• B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
• B29B 17/00 - Recovery of plastics or other constituents of waste material containing plastics
• B32B 17/04 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like in the form of fibres or filaments bonded with or embedded in a plastic substance
• B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
• B32B 27/32 - Layered products essentially comprising synthetic resin comprising polyolefins

Abstract

The present invention relates to methods of treating liver disease using compositions comprising macrophages.

IPC Classes  ?

• A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention provides a method of monitoring radiotherapy response in a subject having prostate cancer, the method comprising: a) providing a cell-free DNA (cfDNA)-containing sample obtained from the subject; b) performing DNA sequencing on the cfDNA-containing sample in order to generate methylation sequencing reads; c) assessing methylation levels within the cfDNA at each of a plurality of pre-determined differentially methylated regions (DMRs) to generate a sample methylation profile, wherein each pre-determined DMR is associated with a tissue of origin, thereby detecting the presence of one or more tissues of origin; and d) determining the radiotherapy response of the subject based on the sample methylation profile Also provided are methods of treating a subject with prostate cancer using adaptive radiotherapy.

IPC Classes  ?

• C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present disclosure relates to methods of screening salmonids for increased resistance to viral infection, such as infectious pancreatic necrosis virus (IP-NV) infection. The present disclosure also relates to fish which have been genetic modified to have increased resistance to viral/IPNV infection. The present disclosure further relates to the use of these fish, which have been identified. or genetically modified to have increased genetic resistance. in aquaculture breeding programs and/or production. The present disclosure further relates to the use of small molecules which target NAE1 and their use in therapy or prevention of viral/IPNV infection.

IPC Classes  ?

• A01K 67/0275 - Genetically modified vertebrates, e.g. transgenic
• A61K 31/708 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
• C07K 14/46 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

The present disclosure relates to the development of novel cleavable peptide probes for use in detecting granzyme B, as well as methods for using the probes in medical and biological settings. The probes may comprise a fluorescent moiety conjugated or bound to the peptide, and quencher moiety conjugated or bound to the peptide and upon cleavage of the peptide, the fluorescent moiety becomes dequenched.

IPC Classes  ?

• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

A method of separating a metal from a solution comprises adding to the solution a compound having a structure represented by Formula (I): wherein: R1, R2, R3 and R4 are each independently a substituted or unsubstituted aryl group or a substituted or unsubstituted C1-C8 hydrocarbyl group: and Z is a C2-C6 hydrocarbyl group or an aryl group.

IPC Classes  ?

• C22B 3/44 - Treatment or purification of solutions, e.g. obtained by leaching by chemical processes
• C22B 3/00 - Extraction of metal compounds from ores or concentrates by wet processes
• C22B 11/00 - Obtaining noble metals
• C22B 58/00 - Obtaining gallium or indium

Abstract

A medical image processing apparatus includes a memory storing training medical images, each annotated with respective weak supervision annotation information relating to at least one object represented in the training medical image, the at least one object comprising an anatomical object, a pathology, or a medical device; and processing circuitry configured to use the plurality of training medical images to train a deep learning network to perform a task, wherein the training of the deep learning network includes training a compositional latent representation comprising a plurality of kernels, wherein the training of the compositional latent network includes using the weak supervision annotation information to provide weak supervision of the training of the computational latent representation, thereby guiding the compositional latent representation towards a representation in which different ones of the kernels are representative of different objects, the different objects comprising at least one anatomical object, pathology, or medical device.

IPC Classes  ?

• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
• G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion

Abstract

A turbine blade (10), a turbine (1) comprising said turbine blade (10), a trailing edge assembly (11', 11'', 111') for a turbine blade (10', 10'', 110') and a kit of parts for a turbine blade (10', 10'', 110'). The turbine blade (10) comprising a leading edge (12), a trailing edge (14), a pressure side (16), and a suction side (18); wherein each of the pressure side (16) and the suction side (18) extend between the leading edge (12) and the trailing edge (14); wherein the pressure side (16) is formed of a first wall (20); wherein the suction side (18) is formed of a second wall (22); and wherein the first wall (20) and the second wall (22) are configured to be independently deformable and move relative to each other proximal the trailing edge (14) in response to loading on the turbine blade (10).

IPC Classes  ?

• F03B 3/12 - BladesBlade-carrying rotors
• F03B 13/26 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using tide energy
• F03D 1/06 - Rotors

Abstract

A memory computing device is disclosed comprising: a bitcell array comprising a plurality of bitcells, each bitcell being connected to a respective wordline and bitline; an address decoder connected to the bitcell array; and peripheral circuitry connected to the bitcell array, comprising pre-charging and pre-discharging circuitry, sensing circuitry and output circuitry. The address decoder is configured to receive an address for a wordline and to activate the wordline corresponding to the address. The peripheral circuitry is configured to: pre-charge or pre-discharge a bitline in the bitcell array using the pre-charging and pre-discharging circuitry; sense the bitline using the sensing circuitry; receive a stochastic multiplier as input data for multiplication with read bitcell data in the bitcell array, wherein the read bitcell data constitutes a stochastic multiplicand; perform, by the peripheral circuitry of the memory computing device, a digital stochastic multiplication between the input data and the read bitcell data; and output a result of the stochastic multiplication.

IPC Classes  ?

• G11C 7/10 - Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers
• G06F 7/523 - Multiplying only
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
• G11C 11/419 - Read-write [R-W] circuits
• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using elements simulating biological cells, e.g. neuron
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or

Abstract

A fluidic apparatus 105 comprises an inlet 111; an outlet 112; and a first group of compartments 121 comprising two or more first compartments 121a, 121b, 121c, 121 d arranged in parallel between the inlet 111 and the outlet 112; wherein each of the first compartments 121a, 121b, 121c, 121 d is configured to receive a respective cell culture insert 150, and wherein a flow of fluid between the inlet 111 and the outlet 112 is evenly distributed and/or substantially identical between the first compartments 121a, 121b, 121c, 121d.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B29C 64/00 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

Abstract

A photon sensing device for photon sensing comprising: a plurality of photon detectors coupled to a plurality of shift registers, wherein the plurality of photon detectors and shift registers are provided as part of a configurable circuitry configurable to combine two or more of the plurality of shift registers and to combine two or more photon detectors to form one or more combined shift registers and one or more combined photon detectors, respectively.

IPC Classes  ?

• G01S 7/4863 - Detector arrays, e.g. charge-transfer gates
• G01S 7/4914 - Detector arrays, e.g. charge-transfer gates
• G01S 17/10 - Systems determining position data of a target for measuring distance only using transmission of interrupted, pulse-modulated waves
• G01S 17/36 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated with phase comparison between the received signal and the contemporaneously transmitted signal
• G01S 17/894 - 3D imaging with simultaneous measurement of time-of-flight at a 2D array of receiver pixels, e.g. time-of-flight cameras or flash lidar

Abstract

A fuzzy logic gate comprising an input node configured to receive an analogue input signal. A complementary metal oxide semiconductor (CMOS) logic gate is connected to the input node. A tunable load is connected to the CMOS logic gate such that the tunable load is provided on a current path connected to an output node. The output node is configured to output an analogue output signal.

IPC Classes  ?

• G06N 3/065 - Analogue means
• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs
• G11C 11/413 - Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing, timing or power reduction
• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using elements simulating biological cells, e.g. neuron
• H03K 19/20 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits characterised by logic function, e.g. AND, OR, NOR, NOT circuits

Abstract

An apparatus (14) for pitching a turbine blade (12) comprises a pitching arrangement 5 (26) defining a pitching axis (p) and a blade mounting arrangement (28). The blade mounting arrangement (28) comprises a member (32) configured to receive a turbine blade (12) thereon. The member (32) is pivotably coupled to the pitching arrangement (26) and is configured to space the turbine blade (12) from the pitching axis (p). The pitching arrangement (20) is configured to control rotation of the blade mounting 10 arrangement (28) around the pitching axis (p) in response to forces acting on the turbine blade (12).

IPC Classes  ?

• F03D 1/06 - Rotors
• F03B 13/26 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using tide energy
• F03B 17/06 - Other machines or engines using liquid flow, e.g. of swinging-flap type

Abstract

The present disclosure relates to methods of screening tilapia for increased genetic resistance to viral infection, such as Tilapia Lake Virus, as well as the use of these fish, which have been identified as having increased genetic resistance, in aquaculture breeding programs and production.

IPC Classes  ?

• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

Abstract

A memory device for storing data comprising: voltage divider circuitry comprising at least one memory element, wherein the at least one memory element is operable or selected to be in a resistance and/or impedance state representative of at least part of the data, wherein the voltage divider circuitry is configured to divide a voltage in dependence on the resistance and/or impedance state of the at least one memory element as part of a data read and/or a data write operation, wherein the at least one memory element is capacitive and is connected to one or more further capacitive elements such that the voltage divider circuitry comprises a capacitor divider arrangement.

IPC Classes  ?

• G11C 15/00 - Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores
• G11C 15/04 - Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores using semiconductor elements

Abstract

The present disclosure relates to extracellular vesicles (EVs) (and their contents) from a pluripotent stem-cell derived endothelial cell product (ECP); as well as their isolation; uses and methods employing the EVs in therapy, such as in promoting angiogenesis and/or neovascularisation.

IPC Classes  ?

• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/44 - VesselsVascular smooth muscle cellsEndothelial cellsEndothelial progenitor cells
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 9/12 - Antihypertensives
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• B01D 15/34 - Size-selective separation, e.g. size-exclusion chromatographyGel filtrationPermeation
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances

Abstract

The present disclosure provides methods of determining whether or not to administer a subject gabapentin, said method comprising assessing the genetic profile of a subject considered for a gabapentin-based therapy and determining, on the basis of the genetic profile, whether or not to administer the subject gabapentin.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

MECP2 EXPRESSION CASSETTES. The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5′ to 3′: a 5′ transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3′ untranslated region (3′UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes. The nucleic acid molecules and viral vectors disclosed herein provide novel tools for expressing MeCP2 and are of particular value in the treatment of disorders associated with reduced MeCP2 activity, including Rett syndrome.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 15/86 - Viral vectors

Abstract

A system comprising: a nematic liquid crystal, and at least one interface in contact with the nematic liquid crystal, wherein the interface comprises a first interface region on one side of the nematic liquid crystal and a second interface region on another side of the nematic liquid crystal, the interface comprising nucleation sites to form defect lines in the nematic liquid crystal extending across the nematic liquid crystal from the first interface region to the second interface region.

IPC Classes  ?

• C09K 19/54 - Additives having no specific mesophase
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C09K 19/52 - Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives

Abstract

An apparatus (105) for manufacturing a tubular biological structure (165) comprises a tubular member (150) configured to be rotated, wherein the tubular member (150) comprises a tubular wall extending from a first end (151) and a second end (152), wherein the tubular member (150) is configured to receive a biological material (160) on an internal surface (154) thereof, and wherein the tubular member (150) comprises at least one opening (156) through the tubular wall configured to allow egress of excess biological material (160), in use.

IPC Classes  ?

• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• A61L 27/38 - Animal cells
• B29C 41/04 - Rotational or centrifugal casting, i.e. coating the inside of a mould by rotating the mould

Abstract

A sensor device (10) for photon-based imaging comprising one or more photon detectors configured to produce a plurality of photon detection signals in response to a plurality of photon detection events, wherein each photon detection event has a corresponding detection time and wherein the detection times of the plurality of photon detection events are distributed in accordance with a distribution over time; and processing circuitry configured to perform a sketching process using timing information of the plurality of photon detection events to obtain a compressed representation of the distribution over time, wherein the sketching process comprises: generating a plurality of feature values based on the timing information of the plurality of photon detection events using one or more feature functions; combining the generated plurality of feature values to obtain the compressed representation of the distribution over time, wherein the feature functions have one or more properties such that combining the plurality of feature values generated using the one or more feature functions preserves signal information and/or supresses background information and/or distinguishes signal information from background information in the compressed representation, wherein the compressed representation is such that at least one or more desired parameters of the distribution over time can be estimated by performing a parameter estimation process using the compressed representation, wherein the parameter estimation process is based on a model of the distribution over time.

IPC Classes  ?

• G01S 17/894 - 3D imaging with simultaneous measurement of time-of-flight at a 2D array of receiver pixels, e.g. time-of-flight cameras or flash lidar
• G01S 7/4865 - Time delay measurement, e.g. time-of-flight measurement, time of arrival measurement or determining the exact position of a peak
• G01S 7/487 - Extracting wanted echo signals
• G01S 17/10 - Systems determining position data of a target for measuring distance only using transmission of interrupted, pulse-modulated waves

Abstract

A data processing apparatus comprises: a memory configured to store a trained model; and processing circuitry configured to: receive at least one dataset that comprises d variables and n samples; determine variances associated with the variables by processing the dataset using the model; determine an order of the variables based on the determined variances, including iteratively removing at least one node or variable represented by said at least one node thereby to determine the order.

IPC Classes  ?

• G06F 7/24 - Sorting, i.e. extracting data from one or more carriers, re-arranging the data in numerical or other ordered sequence, and re-recording the sorted data on the original carrier or on a different carrier or set of carriers
• G06F 17/18 - Complex mathematical operations for evaluating statistical data

Abstract

The disclosure relates to synthetic super-enhancers activated by one or more transcription factors. In particular, the present disclosure describes synthetic super-enhancers that are activated by one or more transcription factors expressed in a target cell and used to express transgenes, such as adverse payloads, upon activation of the synthetic super-enhancer by the transcription factor(s).

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/86 - Viral vectors

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present disclosure relates to compositions for use in the treatment of a class of Rett syndrome mutations, namely C-terminal deletions, comprising a base editor to alter a stop codon in a mutant MECP2 gene. This alteration does not return the gene to its wild-type (WT) form, but re-establishes normal levels of a version which is functionally equivalent to a wild¬ type version of the MeCP2 protein.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/22 - Ribonucleases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Abstract

A computer implemented method of providing and an indication of the probability of myocardial infarction using cardiac biomarker measurements comprises combining measured with other clinical indicators in statistical model to compute the probability of a subject having suffered myocardial infarction, the statistical model using a machine learning algorithm. A decision tool and a system for implementing the method are disclosed.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16B 40/20 - Supervised data analysis
• G06N 20/20 - Ensemble learning

Abstract

Disclosed is a cohort of anti-proliferative microRNAs (miRs) wherein each member of the cohort (or combinations thereof) represent a target for modulating cell proliferation (and migration), influencing (or modulating) vascular remodelling and the treatment of various vascular complications, vascular injury vascular disease and (for example) disorders, diseases, syndromes and/or conditions which affect vessels and/or vascular systems of the human or animal body.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 9/12 - Antihypertensives

Abstract

A method of selectively extracting rhodium from an aqueous hydrochloric acid solution comprising rhodium and iridium, the method comprising: mixing a first aqueous hydrochloric acid solution comprising rhodium and iridium with an immiscible organic solution comprising a first organic solvent and an extractant system which selectively extracts the rhodium into the organic solution, wherein the first aqueous hydrochloric acid solution has a hydrochloric acid concentration in a range 2 M to 7 M; separating the organic solution comprising the rhodium from the first aqueous hydrochloric acid solution; mixing the separated organic solution with an aqueous stripping solution in order to strip the rhodium from the organic solution into the aqueous stripping solution; separating the organic solution from the aqueous stripping solution; and re-using the organic solution for further extraction of rhodium.

IPC Classes  ?

• B01D 11/00 - Solvent extraction
• C01G 55/00 - Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum
• C22B 3/26 - Treatment or purification of solutions, e.g. obtained by leaching by liquid-liquid extraction using organic compounds
• C22B 11/00 - Obtaining noble metals

Abstract

Disclosed are constructs configured to express adverse (for example cytotoxic and immunomodulatory) payloads in cells, which constructs may be used to treat or prevent recurrent/secondary cancer/tumours and to prime, induce, raise or promote an immune response which is effective against a recurrent/secondary cancer/tumour which might arise from said primary cancer/tumour.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/67 - General methods for enhancing the expression

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/67 - General methods for enhancing the expression
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

Disclosed is a construct for use in a method of transcriptional activation of a complex genomic locus. The construct comprises a single guide RNA (sgRNA) binding a regulatory element of the said complex genomic locus, and a deactivated Cas. The construct may be introduced into cells including the genomic locus of interest in order to activate the regulatory element to transcribe multiple transcripts within said complex genomic locus.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present disclosure relates to a fluid level and/or fluid composition monitoring system (2) comprising a radiofrequency sensor (4) configured to be included in an item of furnishing or other item for use by a patient or other subject and a control system (8) configured to receive a signal from the radiofrequency sensor and to determine a level of fluid and/or a composition of fluid in a part (6a) of a patient or other subject's body (6) in vivo based on the signal.

IPC Classes  ?

• A61B 5/0507 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves using microwaves or terahertz waves

Abstract

An optical device comprises a plurality of optical components comprising at least one primary mirror and further comprising at least one scanning mirror component and/or at least one spatial light modulator and/or at least one digital mirror, wherein the plurality of optical components are configured to direct light from an input/output module to an objective module and from the objective module to the input/output module and to manipulate a position and/or pattern of the light; and a mono-block structure in which the plurality of optical components is mounted, wherein the mono-block structure is a continuous single structure having walls and a base.

IPC Classes  ?

• G02B 26/10 - Scanning systems
• G02B 21/24 - Base structure
• G02B 7/00 - Mountings, adjusting means, or light-tight connections, for optical elements
• G02B 7/182 - Mountings, adjusting means, or light-tight connections, for optical elements for prismsMountings, adjusting means, or light-tight connections, for optical elements for mirrors for mirrors
• G02B 21/00 - Microscopes

Abstract

The invention relates to a short single-stranded DNA or RNA aptamer that is capable of binding the TDP-43 protein and of detecting all of the different TDP-43 structures individually, from the soluble monomer to the TDP-43 larger aggregates. The aptamer of the invention is also capable of inhibiting aggregation of TDP-43. Because of these properties, the RNA aptamer of the invention is suitable for use in both the diagnosis and therapeutic treatment and prevention of TDP-43-related proteinopathies, such as ALS and FTD.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

An endoscopic device comprises a wall defining an interior space, a working channel in, or defined by, the interior space, and at least one optical fibre embedded or otherwise provided in the wall, wherein the endoscopic device has an outer diameter of less than 2.5 mm.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Recombinant human FMR1 constructs and related methods for treating Fragile X syndrome and related disorders in a subject are provided.

IPC Classes  ?

• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/864 - Parvoviral vectors

Abstract

FMR1FMR1 constructs and related methods for treating Fragile X syndrome and related disorders in a subject are provided.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/864 - Parvoviral vectors
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

A macropixel is disclosed. The macropixel comprises a plurality of pixels, each pixel comprising a Single Photon Avalanche Diode (SPAD). The macropixel also comprises a memory configured to store: a plurality of counts, each count associated with a pixel of the plurality of pixels; and a plurality of saturation bits, each saturation bit associated with a count of the plurality of counts. The macropixel also comprises saturation detection circuitry configured to gate a recharge of each SPAD based on a state of the respective saturation bit.

IPC Classes  ?

• H04N 25/773 - Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components comprising A/D, V/T, V/F, I/T or I/F converters comprising photon counting circuits, e.g. single photon detection [SPD] or single photon avalanche diodes [SPAD]

Abstract

The invention relates to an ophthalmological viscoelastic composition comprising an aqueous solution having a viscoelastic base component and having an additive including at least one water-soluble polymer without covalent bonding to the base component. The additive increases an extensional viscosity of the composition compared to the composition without additive. In addition, the additive is present in a concentration equal to or lower than a concentration of the base component in the aqueous solution.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61P 27/12 - Ophthalmic agents for cataracts

Abstract

This invention relates to an electrode comprising (a) as an anion, a halide of either bismuth or antimony, wherein the halide is bromide or iodide, and (b) a cation. The invention also relates to a sodium ion or lithium ion battery comprising the electrode, and a laptop, mobile phone, electric vehicle or grid storage system comprising the sodium ion or lithium ion battery. In addition, the invention relates to a method of making the electrode comprising the steps of: (a) preparing a first solution comprising a halide of either bismuth or antimony, wherein the halide is bromide or iodide, (b) preparing a second solution comprising a cation, (c) mixing the first and second solutions, and (d) drying the resulting product.

IPC Classes  ?

• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulatorsProcesses of manufacture thereof
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds
• H01M 4/66 - Selection of materials
• C07F 9/94 - Bismuth compounds

Abstract

A system to limit the expression of a vector-derived transgene within a window that alleviates the disease-causing genetic deficiency without producing overexpression toxicity is described. This provides for ‘dosage-insensitivity’, whereby cells or tissues receiving more vector-derived transgene are disproportionately suppressed through an in-built single gene circuit that can regulate adaptively.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

The disclosure is in part directed to a method of treating a cancer, e.g., a B-cell cancer, in a patient in need thereof, comprising administering to the patient an effective amount of a disclosed tyrosine kinase inhibitor. In some embodiments, the cancer harbors a BTK mutation.

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

A receiving device (12) for receiving an optical communication signal, wherein the optical communication signal comprises an encoded or modulated signal, the device comprising: one or more photodetectors (12) configured to produce photodetector signals in response to detecting photons; one or more further photodetectors (14) configured to produce further photodetector signals; a controller (16) configured to select an operational mode of the receiving device in dependence on at least a light level, wherein the operational mode is one of at least a first mode in which a demodulation or decoding process is performed on the photodetector signals and a second mode in which the demodulation or decoding process is performed on the further photodetector signals, and a photon count limiter (18) associated with the one or more photodetector for controlled limiting of the photon count of the one or more photodetectors in dependence on at least a light level.

IPC Classes  ?

• H04B 10/67 - Optical arrangements in the receiver
• H04B 10/112 - Line-of-sight transmission over an extended range

Abstract

A nucleic acid molecule for controllable gene expression comprises: a double-stranded section, comprising a sequence for expression; and a single-stranded overhanging section configured to bind to the double-stranded section to form a nucleic acid triplex.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

The present invention relates to the detection of disease states such as clonal haematopoiesis and cancer as well as fetal screening by analysing thrombocytes for disease associated markers. The methods comprises steps of providing a biological sample comprising thrombocytes; extracting nucleic acid from said biological sample; analysing said nucleic acid to identify the presence of one or more clonal haematopoiesis associated mutations or cancer associated nucleic acid fragments; and indicating the presence or prognosis of clonal haematopoiesis or cancer based on the presence of one or more clonal haematopoiesis associated mutations or cancer associated nucleic acid fragments; or or analysing the nucleic acids for genetic information related to the foetus.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A sensing device comprising: a plurality of electrodes configured to be distributed about one or more surfaces of a deformable object, wherein the plurality of electrodes are operable to generate capacitance signal output from a plurality of selected pairings of the plurality of electrodes, wherein the plurality of electrodes are distributed about the one or more surfaces of a deformable object such that the plurality of selected pairings comprise at least one proximate pairing and at least one non-proximate pairing, wherein the generated capacitance signal output for a pairing of electrodes is dependent on at least one of: a distance between the electrodes; shape and/or orientation of the electrodes and at least one property of the material between the pairing.

IPC Classes  ?

• G01B 7/16 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring the deformation in a solid, e.g. by resistance strain gauge
• G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
• G01L 5/22 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring the force applied to control members, e.g. control members of vehicles, triggers
• G01D 5/24 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance

Abstract

There is provided a method of targeting mitochondrial biogenesis and mitochondrial transport from the cell body to axon to protect acutely demyelinated axons from degeneration. The method may comprise increasing mobilization of mitochondria from the neuronal cell body to the demyelinated axon to treat demyelinating disorders and provide a novel neuroprotective strategy for vulnerable acutely demyelinated axons. The method may comprise mitochondrial biogenesis in the demyelinated axon to treat demyelinating disorders and provide a novel neuroprotective strategy for vulnerable acutely demyelinated axons. The method comprises a variety of compounds and strategies for increasing mitochondrial transport and biogenesis to the demyelinated axon in both the peripheral and central nervous systems.

IPC Classes  ?

• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/385 - Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A tunable CMOS circuit comprising a CMOS element and a tunable load. The CMOS element is configured to receive an analogue input signal. The tunable load is connected to the CMOS element and configured to set a switch point of the CMOS element. The CMOS element is configured to output an output current that is largest when the analogue input signal is equal to the switch point. The combination of a CMOS element with a tunable load may also provide a hardware implementation of fuzzy logic. A fuzzy logic gate comprises an input node, a CMOS logic gate, a tunable load, and an output node. The input node is configured to receive an analogue input signal. The CMOS logic gate is connected to the input node. The tunable load is connected to the CMOS logic gate such that the tunable load is provided on a current path connected to the output node. The output node is configured to output an analogue output signal.

IPC Classes  ?

• G06N 3/065 - Analogue means
• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs
• G11C 11/413 - Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing, timing or power reduction
• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using elements simulating biological cells, e.g. neuron
• H03K 19/20 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits characterised by logic function, e.g. AND, OR, NOR, NOT circuits

Abstract

The disclosure provides for optimized therapeutic MECP2 polynucleotide constructs utilized for replacing or compensating for the loss of MeCP2 function in patients with Rett Syndrome. Suitably, the disclosure provides gene therapy cassettes to enable better regulatory control of the MeCP2 protein, including tunable systems that allow MECP2 gene therapy to be expressed at a desired moderate level and demonstrate expression of the vector-derived transgene within a window that alleviates the disease-causing genetic deficiency without producing undesired side effects including overexpression toxicity.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 15/86 - Viral vectors

Abstract

The disclosure provides for optimized therapeutic MECP2 polynucleotide constructs utilized for replacing or compensating for the loss of MeCP2 function in patients with Rett Syndrome. Suitably, the disclosure provides gene therapy cassettes to enable better regulatory control of the MeCP2 protein, including tunable systems that allow MECP2 gene therapy to be expressed at a desired moderate level and demonstrate expression of the vector-derived transgene within a window that alleviates the disease-causing genetic deficiency without producing undesired side effects including overexpression toxicity.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

There is described a computer implemented method for efficient aggregation of a Television White Space (TVWS) spectrum for backhaul use, said method comprising: providing a TVWS conversion substrate with a single antenna for combining multiple non-contiguous chunks of TVWS spectrum with said single antenna; providing a Multi-Path transport protocol; and providing an uncoupled, cross-layer congestion control algorithm for Multi-path Transmission Control Protocol (MPTCP).

IPC Classes  ?

• H04W 16/14 - Spectrum sharing arrangements

Abstract

The improved 4-5 day, optionally 3-5 day GMP-compliant in-vitro method enables the production of macrophages from monocytes that benefits from a shorter cell culture time, fewer interventions whilst maintaining the desired characteristics of the human macrophages. The present invention describes a method wherein the monocytes are cultured in medium comprising one or more growth actors to stimulate macrophages with a pro-regenerative phenotype. The method described herein is xeno-free, serum-free and GMP compliant. In addition, further disclosed are macrophages produced according to the present invention and the use of said macrophages in the treatment of liver diseases, such as liver cirrhosis.

IPC Classes  ?

• C12N 5/0786 - MonocytesMacrophages
• A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells

Abstract

The invention relates to methods for purifying and isolating at least one RNA molecule which interacts with an RNA-binding protein (RBP). The invention also provides nucleic acid adaptors and primers for use in such methods.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
• C12Q 1/6869 - Methods for sequencing

Abstract

There is provided a method, systems and device to provide an indication of the probability of acute heart failure in a subject/individual. Suitably a device, systems and methods to determine a likelihood score based upon the concentration of natriuretic peptides in blood and at least two other clinical parameters. The method of determining acute heart failure can comprise the steps of combining the level of natriuretic peptide in a sample from an individual with at least two other clinical parameters from the individual in a statistical model to compute the probability of acute heart failure for the individual patient wherein the level of natriuretic peptide is provided as a continuous variable in the model.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G06N 20/20 - Ensemble learning
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The present invention relates to a digital silicon photomultiplier, methods of operating a digital silicon photomultiplier and a device comprising one or more digital silicon photomultipliers. The digital silicon photomultiplier may comprise at least one least one pixel, wherein each pixel includes at least one single photon avalanche photodiode and a toggle operatively connected to each of the at least one single photon avalanche photodiodes. The toggle may output at least one transition wherein each transition represents a detection of a photon. A programmable divider may be operatively connected to each pixel, wherein each programmable divider is programmed with a divisor and each programmable divider receives a first set of transitions and outputs a second set of transitions, wherein each transition in the first set of transitions represents a detection of a photon by a single photon avalanche photodiode of a respective pixel and each transition of the second set of transitions represents a number of detected photons of the respective pixel equivalent to the divisor.

IPC Classes  ?

• G01T 1/208 - Circuits specially adapted for scintillation detectors, e.g. for the photo-multiplier section

Abstract

A method of identifying stable peptides from a protein, said method comprising: obtaining a peptide from a protein; comparing a solvent-accessible surface area (SASA) of the peptide with a SASA of a corresponding peptide region within the protein; using a result of the comparison to determine whether or not the peptide is structurally stable relative to the corresponding peptide region within the protein. Also disclosed is use of the method to identify stable immunogenic epitopes of SARS-CoV-2, and methods of detecting an antibody response.

IPC Classes  ?

• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present disclosure relates to the development of novel constructs that are specifically cleaved by fibroblast activation protein-α (FAP) and uses thereof in assays for detecting FAP. Particular constructs include a fluorescence resonance energy transfer (FRET) probe comprising a fluorescent moiety and a quencher moiety attached to a FAP cleavable peptide sequence and optionally including a solubilising moiety, which may be a polyethylene glycol (PEG) derivative.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 49/00 - Preparations for testing in vivo
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

A method of performing Raman spectroscopy comprising: generating wavelength shifted excitation light for exciting a Raman response from at least one sample, wherein the wavelength shifted excitation light comprises at least two excitation wavelengths; providing the wavelength shifted excitation light to the at least one sample and collecting signal light from the at least one sample; obtaining response signals from the collected signal light; processing the obtained response signals to determine a Raman response and a fluorescence response, wherein determining the Raman response uses at least one characteristic of an expected Raman response to the wavelength shifted excitation light and wherein determining the fluorescence response uses at least one characteristic of an expected fluorescence response to the shifted excitation light.

IPC Classes  ?

• G01N 21/65 - Raman scattering

Abstract

To be able to adequately provide desired services over a 5G mobile service network, the 5G communication infrastructures requires a much-improved flexibility in resource management. Network operators are foreseen to deploy network slicing, by isolating dedicated resources and providing customised logical instances of the physical infrastructure to each service. A critical operation in performing management and orchestration of network resources is the anticipatory provisioning of isolated capacity to each network slice. Accordingly, it is necessary to obtain an estimate of service level demands. However, the estimation of such service level demands is typically obtained via deep packet inspection, which is a resource intensive and time-consuming process. Therefore, it is typically not possible to provide updated accurate estimates at a frequency suitable for use in accurate prediction of a future per-service traffic consumption, without an undesirable level of computational and time resources being required. The present invention provides a distributed network traffic data decomposition method which makes use of a neural network to provide an accurate future per-service traffic consumption prediction without deep-packet inspection or another resource intensive analysis method.

IPC Classes  ?

• H04L 41/147 - Network analysis or design for predicting network behaviour
• H04L 41/16 - Arrangements for maintenance, administration or management of data switching networks, e.g. of packet switching networks using machine learning or artificial intelligence
• H04L 43/028 - Capturing of monitoring data by filtering

Abstract

The present disclosure relates to a method of coupling a first carbon atom with a second carbon atom to form a C-C bond and a kit suitable for said method. The method comprises contacting carbon atoms with microbially supported metal nanoparticles. The microbially supported metal nanoparticles are prepared by contacting metal reducing microbes with a source of metal under anaerobic conditions and the carbon atoms and microbially supported metal nanoparticles are contacted in a liquid in the presence of a surfactant. The kit comprises microbially supported metal nanoparticles prepared by contacting metal reducing microbes with a source of metal under anaerobic conditions; and a surfactant.

IPC Classes  ?

• B01J 23/44 - Palladium
• B01J 37/36 - Biochemical methods
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 37/16 - Reducing
• C07C 41/30 - Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
• C07B 37/04 - Substitution

Abstract

There is disclosed a method of aiding diagnosis of endometriosis in a female subject. The method comprises comparing a level of 2-methyladenosine detected in a biological sample obtained from the female subject with a baseline level of 2-methyladenosine. There is also disclosed a method of aiding the assessment of endometriosis treatment in a female subject identified as having endometriosis..

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present disclosure relates to methods of screening salmonids for increased resistance to viral infection, such as infectious pancreatic necrosis virus (IPNV) infection. The present disclosure also relates to fish which have been genetic modified to have increased resistance to viral/IPNV infection. The present disclosure further relates to the use of these fish, which have been identified, or genetically modified to have increased genetic resistance, in aquaculture breeding programs and/or production. The present disclosure further relates to the use of small molecules which target NAE1 and their use in therapy or prevention of viral/IPNV infection.

IPC Classes  ?

• C07K 14/46 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

There is described a method of producing a flexible structure and sensor devices incorporating the former, such as wireless LC sensors, that comprises a plurality of thin-film layers of elastomeric material and at least one layer of micro-wrinkled electrically conductive material. The method includes steps leading to 2D wrinkled metallised polydimethylsiloxane (PDMS) layers enabling considerable flexibility with negligible bending failure for angles up to 180 degrees.

IPC Classes  ?

• G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
• H05K 3/02 - Apparatus or processes for manufacturing printed circuits in which the conductive material is applied to the surface of the insulating support and is thereafter removed from such areas of the surface which are not intended for current conducting or shielding
• H05K 3/46 - Manufacturing multi-layer circuits

Abstract

The present disclosure relates to methods of screening salmonids for increased resistance to viral infection, such as infectious pancreatic necrosis virus (IPNV) infection. The present disclosure also relates to fish which have been genetic modified to have increased resistance to viral/IPNV infection. The present disclosure further relates to the use of these fish, which have been identified, or genetically modified to have increased genetic resistance, in aquaculture breeding programs and/or production. The present disclosure further relates to the use of small molecules which target NAE1 and their use in therapy or prevention of viral/IPNV infection.

IPC Classes  ?

• C07K 14/46 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

1211113245672n2p2q282r921022, alkoxy, aryloxy, alkylamino, arylamino, carboxyl and carboxamide; R41111 are each independently selected from a group consisting of alkyl, alkenyl and aryl; and n is selected from a group consisting of 0, 1, 2, 3, 4, 5 and 6, p is selected from a group consisting of 0, 1, 2, 3, 4, 5 and 6, q is selected from a group consisting of 0, 1, 2, 3, 4, 5 and 6, and r is selected from a group consisting of 0, 1, 2, 3, 4, 5 and 6. The disclosure also relates to pharmaceutical compositions, therapeutic uses and process for preparing the compound of the disclosure.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61P 35/00 - Antineoplastic agents

Abstract

A method comprises providing a thermoplastic polymer composite article (100) comprising a thermoplastic polymer, wherein the thermoplastic polymer is an addition polymer derived from at least one first addition monomer; contacting a portion of the article with a solvent-free composition comprising at least one polymerisable compound, the at least one polymerisable compound comprising at least one second addition monomer; and polymerising the composition at ambient temperature, wherein the at least one polymerisable compound does not include a polymer.

IPC Classes  ?

• B05D 7/02 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to macromolecular substances, e.g. rubber
• B29C 73/02 - Repairing of articles made from plastics or substances in a plastic state, e.g. of articles shaped or produced by using techniques covered by this subclass or subclass using liquid or paste-like material
• B29C 65/48 - Joining of preformed partsApparatus therefor using adhesives
• B32B 37/00 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
• C08J 5/12 - Bonding of a preformed macromolecular material to the same or other solid material such as metal, glass, leather, e.g. using adhesives
• C08J 7/06 - Coating with compositions not containing macromolecular substances

Abstract

12344 are each independently a substituted or unsubstituted aryl group or a substituted or unsubstituted C1-C8 hydrocarbyl group; and Z is a C2-C6 hydrocarbyl group or an aryl group.

IPC Classes  ?

• C22B 3/44 - Treatment or purification of solutions, e.g. obtained by leaching by chemical processes
• C22B 11/00 - Obtaining noble metals
• C22B 58/00 - Obtaining gallium or indium
• C07C 323/60 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
• C22B 3/16 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in organic solutions
• C22B 3/28 - Amines

Abstract

A system that provides the ability to integrate both diagnostic tissue detection and therapeutic tissue treatment functionality in an implantable medical device (IMD), such as a graft or stent. The system comprises: an IMD having a pair of electrodes configured to contact biological tissue at an implant location; an impedance sensor configured to detect data indicative of a complex impedance of the biological tissue at the electrodes for a plurality of frequencies; and an analysis device configured to determine one or more cell types in the biological tissue using information indicative of variation in phase and magnitude of the complex impedance across the plurality of frequencies. The system may include a signal generator for applying a treatment signal to the same electrodes.

IPC Classes  ?

• A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
• A61N 1/375 - Constructional arrangements, e.g. casings

Abstract

A Light Detection and Ranging (LIDAR) circuit includes a non-transitory memory device comprising a first memory and a second memory, and at least one control circuit. The at least one control circuit is configured to execute first memory storage operations to store data indicated by detection signals received from one or more photodetector elements in the first memory during a time between pulses of an emitter signal output from a LIDAR emitter element, and execute second memory storage operations to include previous data indicated by previous detection signals received from the one or more photodetector elements, which was stored in the first memory, in respective memory bins of the second memory. The first and second memory storage operations are executed at least partially concurrently. Related devices and methods of operation are also discussed.

IPC Classes  ?

• G01S 7/4863 - Detector arrays, e.g. charge-transfer gates
• G01S 17/26 - Systems determining position data of a target for measuring distance only using transmission of interrupted, pulse-modulated waves wherein the transmitted pulses use a frequency-modulated or phase-modulated carrier wave, e.g. for pulse compression of received signals
• G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
• G01S 17/931 - Lidar systems, specially adapted for specific applications for anti-collision purposes of land vehicles

Abstract

The invention relates to spiro-(fluorene-9,9'-(thio)xanthene)-based compounds (I) and a process for the preparation of these. The compounds are useful as thermally activated delayed fluorescence material in electroluminescent devices such as organic light-emitting diodes (OLEDs). The invention extends to electroluminescent devices comprising one or more of these compounds as an emitter and a host material.

IPC Classes  ?

• C07F 9/6547 - Six-membered rings condensed with carbocyclic rings or ring systems
• C07F 9/655 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof

Abstract

The present disclosure relates to the development of novel cleavable peptide probes for use in detecting granzyme B, as well as methods for using the probes in medical and biological settings. The probes may comprise a fluorescent moiety conjugated or bound to the peptide, and quencher moiety conjugated or bound to the peptide and upon cleavage of the peptide, the fluorescent moiety becomes dequenched.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase

Abstract

The present disclosure relates to the development of novel cleavable peptide probes for use in detecting granzyme B, as well as methods for using the probes in medical and biological settings. The probes may comprise a fluorescent moiety conjugated or bound to the peptide, and quencher moiety conjugated or bound to the peptide and upon cleavage of the peptide, the fluorescent moiety becomes dequenched.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids

Abstract

There is provided an in vitro three dimensional cell construct for use as a model of the avian intestine derived from avian intestinal tissue comprising avian cells organised into intestinal villi and crypts. Suitably the construct comprises an exterior surface that mimics the apical surface of a chicken intestine. Also provided are methods of making the cell construct and use of the construct as an in vitro intestinal model system to examine an agent including, but not limited to a microbe, a vaccine, a pharmaceutical, a feed additive, a toxin, a pre-biotic, post-biotic, pre pro post biotic, therapeutic, a cell, gene construct, protein, immune-modulator, an intestinal effector agent, a candidate intestinal effector agent, cell signalling inhibitor, or cell signalling activator.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means