Abstract

Methods and systems for performing a bioproduction process are described, the bioproduction process comprising the production of a cellular product by a cell population. The methods include the steps of culturing the cell population at least partially embedded in a hydrogel matrix forming a three-dimensional structure.

IPC Classes  ?

• C12P 21/00 - Preparation of peptides or proteins
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

The invention relates to a system for controlling the deposition of thin layers by gas phase growth in a deposition reactor (10), the gas phase corresponding to a gaseous state or a plasma state, the control system comprising: - a hollow cathode lamp (2); - an optical cavity (3) that contains at least two mirrors (31) and is configured such that light emitted by the light source (2) is trapped in the optical cavity (3) and interacts with the gas phase, resulting in the deposition of thin layers; and - a light analysis system (4) which is configured to analyze light emitted by the hollow cathode lamp (2) and passing through the optical cavity (3), by measuring the optical absorbance of at least one species of the gas phase penetrated by said light.

IPC Classes  ?

• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/28 - Investigating the spectrum
• G01J 3/42 - Absorption spectrometryDouble-beam spectrometryFlicker spectrometryReflection spectrometry
• G01N 21/03 - Cuvette constructions
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/433 - Modulation spectrometryDerivative spectrometry
• C23C 14/54 - Controlling or regulating the coating process
• C23C 16/52 - Controlling or regulating the coating process
• G01J 3/18 - Generating the spectrumMonochromators using diffraction elements, e.g. grating
• H01J 37/32 - Gas-filled discharge tubes
• G01N 21/84 - Systems specially adapted for particular applications

Abstract

The invention relates to a system for controlling the deposition of thin layers by gas phase growth in a deposition reactor (10), the gas phase corresponding to a gaseous state or a plasma state, the control system comprising: - a continuous light source (2); - an optical cavity (3) comprising at least two mirrors, and configured such that a light emitted by the light source is trapped in the optical cavity and interacts with the gas phase, resulting in the deposition of thin layers; and - a spectrometer (4) which is configured to analyze light emitted by the light source (2) and passing through the optical cavity (3), by measuring the optical absorbance of at least one species of the gas phase penetrated by said light.

IPC Classes  ?

• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/28 - Investigating the spectrum
• G01J 3/42 - Absorption spectrometryDouble-beam spectrometryFlicker spectrometryReflection spectrometry
• G01N 21/03 - Cuvette constructions
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• C23C 14/54 - Controlling or regulating the coating process
• C23C 16/52 - Controlling or regulating the coating process
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/18 - Generating the spectrumMonochromators using diffraction elements, e.g. grating
• H01J 37/32 - Gas-filled discharge tubes
• G01N 21/84 - Systems specially adapted for particular applications
• G01P 5/26 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring the direct influence of the streaming fluid on the properties of a detecting optical wave

Abstract

The invention relates to a system for controlling the deposition of thin layers by gas phase growth in a deposition reactor (10), the gas phase corresponding to a gaseous state or a plasma state, the control system comprising: - a continuous light source (2); and - a spectrometer (4) configured to analyze a light emitted by the light source (2) by measuring the optical absorbance of at least one species of the gas phase penetrated by said light, the spectrometer (4) comprising a dispersion stage (400), the dispersion stage being a scalar diffraction grating, the spectrometer (4) not having a diffraction order separation stage.

IPC Classes  ?

• G01J 3/18 - Generating the spectrumMonochromators using diffraction elements, e.g. grating
• G01J 3/28 - Investigating the spectrum
• G01J 3/42 - Absorption spectrometryDouble-beam spectrometryFlicker spectrometryReflection spectrometry
• G01N 21/03 - Cuvette constructions
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• C23C 14/54 - Controlling or regulating the coating process
• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• C23C 16/52 - Controlling or regulating the coating process
• H01J 37/32 - Gas-filled discharge tubes
• G01N 21/84 - Systems specially adapted for particular applications

Abstract

A method for determining, in vitro or ex vivo, the presence in a patient of an infection by a replicating respiratory virus, including a step i) of determining, in a test sample taken from the mouth or nose of said patient, the level of transcripts of at least one marker gene selected from the interferon-stimulated genes, referred to as ISGs; and associated kits.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• C12Q 1/6851 - Quantitative amplification

Abstract

The present invention relates to a FUBPI inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of FUBPI inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules, such as oligonucleotides including siRNA, shRNA and antisense oligonucleotides, which are complementary to FUBPI and capable of reducing a FUBPI mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
• A61P 31/20 - Antivirals for DNA viruses

Abstract

The device (1) for characterizing an evolution of the fluid flow rate profile at a treatment area includes a system (6) for controlling an energy emission probe (4) and an ultrasound imaging probe (5), configured to control the energy emission probe (4) in emission according to successive energy emission phases interspersed with energy emission stop phases, and driving the ultrasound imaging probe (5) in emission before an energy emission phase in order to measure a reference Doppler signal and during the energy emission stop phases.

IPC Classes  ?

• A61B 8/06 - Measuring blood flow
• A61B 8/08 - Clinical applications
• A61N 7/02 - Localised ultrasound hyperthermia

Abstract

222 bearing a metal and/or a metal oxide.

IPC Classes  ?

• B01J 21/06 - Silicon, titanium, zirconium or hafniumOxides or hydroxides thereof
• C07C 11/04 - Ethene
• B01J 23/72 - Copper
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 35/02 - Solids
• B01J 35/10 - Solids characterised by their surface properties or porosity
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves

Abstract

Nanoparticles that can be used as hydrosilylation and dehydrogenative silylation catalysts. The nanoparticles have at least one transition metal with an oxidation state of 0, chosen from the metals of columns 8, 9 and 10 of the periodic table, and at least one carbonyl ligand, preferably a silicide.

IPC Classes  ?

• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• B01J 31/20 - Carbonyls
• B01J 35/02 - Solids
• B01J 35/23 - Catalysts, in general, characterised by their form or physical properties characterised by their non-solid state in a colloidal state
• B01J 35/40 - Catalysts, in general, characterised by their form or physical properties characterised by dimensions, e.g. grain size
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

A binder for an injection moulding composition, the binder includes, in percentage by mass and for a total of 100%: 35% to 60% of a component (a), or polymer base, made of a polymer or a mixture of polymers, each of the polymer being non-amphiphilic and having a mass average molar mass greater than or equal to 5,000 g/mol, 30% to 55% of a component (b), or wax, made of a polymer or a mixture of polymers, each of the polymer being non-amphiphilic and having a mass average molar mass less than 5,000 g/mol, and less than 10% of an amphiphilic component (c), or surfactant, and less than 10% of other components (d). The polymer base comprising 2% to 15% of a styrene-ethylene-butylene-styrene copolymer (SEBS), in percentage by mass based on the mass of the binder.

IPC Classes  ?

• C04B 35/634 - Polymers
• C04B 35/638 - Removal thereof
• C04B 35/64 - Burning or sintering processes

Abstract

An acoustic treatment grid intended to be mounted inside or at the outlet of a duct of a bleed valve of a turbomachine of an aircraft intended to convey a gas flow, the grid comprising a perforated plate and circular orifices traversing the perforated plate along a first direction, the orifices having a diameter and a geometrical center. Each orifice is separated from an adjacent orifice by a space, the length of which is equal to the product of the diameter of said orifice and a spacing coefficient of a value between 1.1 and 6.

IPC Classes  ?

• F02C 7/24 - Heat or noise insulation
• F02C 6/08 - Gas-turbine plants providing heated or pressurised working fluid for other apparatus, e.g. without mechanical power output providing compressed gas the gas being bled from the gas-turbine compressor
• F16K 47/08 - Means in valves for absorbing fluid energy for decreasing pressure and having a throttling member separate from the closure member

Abstract

A selection process is iterative and includes an initialization associating with a so-called current molecule a value of a predetermined molecule descriptor associated with the target molecular structure, and during each iteration of the selection process, the process includes evaluating, for each molecule of a database including a plurality of molecules each associated with a value of the descriptor, a so-called overall similarity measure between the value of the descriptor associated with the molecule and the value of the descriptor associated with the current molecule; selecting molecules from the database having an overall similarity measure greater than a predetermined threshold, the selected molecules being added to the reference subset; and updating the value of the descriptor associated with the current molecule from the values of the descriptors associated with at least some of the molecules belonging to the reference subset.

IPC Classes  ?

• G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
• G16C 20/40 - Searching chemical structures or physicochemical data
• G16C 20/70 - Machine learning, data mining or chemometrics

Abstract

The invention relates to a method for determining, in vitro or ex vivo, the presence in a patient of an infection by a replicating respiratory virus, comprising a step i) of determining, in a test sample taken from the mouth or nose of said patient, the level of transcripts of at least one marker gene selected from the interferon-stimulated genes, referred to as ISGs. The invention also relates to the associated kits. Figure for the abstract: none.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

A device for converting an input DC voltage into an output DC voltage having a predetermined value, includes a set of elementary components comprising: an input voltage source; two output nodes; and a plurality of energy-storing elements, each consisting of one battery or of a plurality of batteries connected in series or in parallel. The converting device further comprises a switching matrix, configured to connect the elementary components to one another in a periodic cycle composed of a plurality of phases so that, for each cycle: Each phase is associated with one different connection configuration chosen so that, in each energy-storing element, the amount of charge at the start of the cycle is equal to the amount of charge at the end of the cycle.

IPC Classes  ?

• H02M 3/158 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
• H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
• H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
• H01M 10/0585 - Construction or manufacture of accumulators having only flat construction elements, i.e. flat positive electrodes, flat negative electrodes and flat separators

Abstract

The device (1) for characterising an evolution in the fluid flow velocity profile in a treatment zone comprises a control system (6) of an energy emission probe (4) and an ultrasonic imaging probe (5), configured to control the emission of the energy emission probe (4) during successive energy emission phases interspersed with phases of stopped energy emission, and to operate the emission of the ultrasonic imaging probe (5) before an energy emission phase, in order to measure a reference Doppler signal and during the stopped energy emission phases.

IPC Classes  ?

• A61B 8/06 - Measuring blood flow
• A61B 8/08 - Clinical applications
• A61N 7/02 - Localised ultrasound hyperthermia

Abstract

A method and system for measuring values of one or several characterizing parameters representative of the kinetics of an assay chemical reaction, including: providing a calibration tool having a reaction chamber; for a given set of defining features, performing a series of calibration experiments under different sets of calibration values of at least one operating parameter; providing a digital calibration model representative of the kinetics of the assay chemical reaction in the calibration tool, where the assay digital calibration model includes one or several characterizing parameters, the values of which have a dependency on the given set of defining features used for the calibration experiments; fitting, by computation, the values of the characterizing parameters for the given set of defining features, based on the series of calibration experiment results; and where the reaction chamber is a stirred-tank reactor.

IPC Classes  ?

• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 21/552 - Attenuated total reflection
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes

Abstract

A discharge grid (22) designed to be mounted inside or at the outlet of a line (21) of a discharge valve (20) of a turbomachine (1) of an aircraft, the discharge grid (22) comprising an upstream face (24) designed to receive a gas flow (F), a downstream face (25) parallel to the upstream face (24) and designed to deliver the gas flow (F) received at the upstream face (24), and orifices (230) passing through the perforated plate (23) from the upstream face (24) to the downstream face (25) and designed to convey the gas flow (F) through the perforated plate (23). The discharge grid (22) comprises, for each orifice (230) of the perforated plate (23), a tubular channel (26) that is coaxial with its associated orifice and projects from the downstream face (25) of the perforated plate (23).

IPC Classes  ?

• F02C 6/08 - Gas-turbine plants providing heated or pressurised working fluid for other apparatus, e.g. without mechanical power output providing compressed gas the gas being bled from the gas-turbine compressor
• F01D 17/10 - Final actuators
• F02K 3/075 - Plants including a gas turbine driving a compressor or a ducted fan in which part of the working fluid by-passes the turbine and combustion chamber the plant including ducted fans, i.e. fans with high volume, low-pressure outputs, for augmenting jet thrust, e.g. of double-flow type controlling flow ratio between flows
• F04D 27/02 - Surge control

Abstract

An acoustic treatment grid (22) designed to be mounted inside or at the outlet of a line (21) of a discharge valve (20) of a turbomachine (1) of an aircraft, this being designed to convey a gaseous flow (F), the grid (22) comprising a perforated plate (23) and circular orifices (230) passing through the perforated plate (23) in a first direction (DA), the orifices (230) having a diameter (D) and a geometric center (C). Each orifice (230) is separated from an adjacent orifice by a space whose length (e) is equal to the product of the diameter (D) of said orifice (230) with a spacing coefficient whose value is between 1.1 and 6.

IPC Classes  ?

• F02C 6/08 - Gas-turbine plants providing heated or pressurised working fluid for other apparatus, e.g. without mechanical power output providing compressed gas the gas being bled from the gas-turbine compressor
• F01D 17/10 - Final actuators
• F02K 3/075 - Plants including a gas turbine driving a compressor or a ducted fan in which part of the working fluid by-passes the turbine and combustion chamber the plant including ducted fans, i.e. fans with high volume, low-pressure outputs, for augmenting jet thrust, e.g. of double-flow type controlling flow ratio between flows
• F04D 27/02 - Surge control

Abstract

A method for producing a porous silicone material including the following steps: 1) implementing a direct emulsion E of silicone in water including: A) a silicone base A crosslinkable by polyaddition or polycondensation; B) at least one nonionic silicone surfactant B having a cloud point between 10 and 50° C.; C) optionally, at least one catalyst C; and D) water; 2) heating the emulsion E to a temperature greater than or equal to 60° C. to obtain a porous silicone material; and 3) optionally, drying the porous silicone material.

IPC Classes  ?

• C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof
• C08L 83/04 - Polysiloxanes
• C08J 9/28 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum

Abstract

The present invention relates to a FUBP1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of FUBP1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules, such as oligonucleotides including siRNA, shRNA and antisense oligonucleotides, which are complementary to FUBP1 and capable of reducing a FUBP1 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 31/20 - Antivirals for DNA viruses
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters

Abstract

Nanoparticles that can be used as hydrosilylation and dehydrogenative silylation catalysts. The nanoparticles have at least one transition metal with an oxidation state of 0, chosen from the metals of columns 8, 9 and 10 of the periodic table, and at least one carbonyl ligand, preferably a silicide.

IPC Classes  ?

• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 31/20 - Carbonyls
• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• B01J 35/02 - Solids
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 49/10 - Organic compounds
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 49/04 - X-ray contrast preparations
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation

Abstract

233222332223322-CHOH-R5 (lc), in which RI, R2, R3, R4 and R5 are as defined in the description. The invention also relates to a method for preparing said tetrazenes.

IPC Classes  ?

• C07C 245/22 - Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond containing chains of three or more nitrogen atoms with one or more nitrogen-to-nitrogen double bonds
• C07C 247/04 - Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
• C07C 255/26 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and singly-bound oxygen atoms bound to the carbon skeleton
• C07F 9/00 - Compounds containing elements of Groups 5 or 15 of the Periodic Table

Abstract

The selection method according to the invention is iterative and comprises an initialisation step (E10) associating with a molecule, referred to as the current molecule, a predetermined descriptor value of molecules associated with the target molecular structure, and, during each iteration (E20) of the selection method: — a step (E30), for each molecule of a database comprising a plurality of molecules each associated with a value of said descriptor, of evaluating a degree of similarity, referred to as overall similarity, between the value of the descriptor associated with said molecule and the value of the descriptor associated with the current molecule; — a step (E40) of selecting molecules of the database having a degree of overall similarity greater than a predetermined threshold, the selected molecules being added (E50) to the reference subassembly; and — a step (E60) of updating the value of the descriptor associated with the current molecule based on values of descriptors associated with at least one portion of the molecules belonging to the reference subassembly.

IPC Classes  ?

• C40B 30/02 - In silico screening
• C40B 50/02 - In silico or mathematical conception of libraries
• G06F 17/30 - Information retrieval; Database structures therefor
• G06F 19/10 - Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology (in silico methods of screening virtual chemical libraries C40B 30/02;in silico or mathematical methods of creating virtual chemical libraries C40B 50/02)
• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)

Abstract

The invention relates to cationic complexes made up of a lanthanide ion Ln3+ and a ligand of formula (I): with the exception of cationic complexes made up of a lanthanide ion Ln3+ and a ligand of one of formulae (I.1) or (I.4) as defined in claim 1, and the salts, solvates and hydrates thereof. The invention also relates to the use of such a complex or of a cationic complex made up of a lanthanide ion Ln3+ and a ligand of formula (I.1) or (I.4) as defined in claim 1, or of one of the salts thereof with an anion, the solvates or hydrates thereof, as an aid to the crystallisation of a biological macromolecule, as well as to crystallisation methods and methods for analysing or determining the structure of a biological macromolecule.

IPC Classes  ?

• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
• G01N 23/22 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• B01D 9/00 - Crystallisation
• C30B 7/14 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions the crystallising materials being formed by chemical reactions in the solution
• C30B 29/58 - Macromolecular compounds

Abstract

The invention relates to an additive manufacturing method for producing a three- dimensional elastomer silicone article. The elastomer silicone article is built up layer by layer by printing a silicone composition crosslinkable by addition reactions comprising at least one organopolysiloxane-polyoxyalkylene copolymer with a 3D printer selected from an extrusion 3D printer or a material jetting 3D printer.

IPC Classes  ?

• C08G 77/12 - Polysiloxanes containing silicon bound to hydrogen
• C08G 77/14 - Polysiloxanes containing silicon bound to oxygen-containing groups
• C08G 77/20 - Polysiloxanes containing silicon bound to unsaturated aliphatic groups
• C08L 83/04 - Polysiloxanes
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
• B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
• B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]

Abstract

The invention provides a high-voltage electrical transformer including: - a magnetic circuit (20); - at least one primary winding (22) and at least one secondary winding (24), each including at least one conductor which is wound in the form of turns around the magnetic circuit (20); - an electrically insulating housing (26) which encapsulates the magnetic circuit (20) and which has an outer envelope surface (28) on which the primary and secondary winding are wound and an inner envelope surface which defines an inner volume in which the magnetic circuit (20) is accommodated, characterized in that each turn of a winding (22, 24) is accommodated in a winding groove which is formed in the outer envelope surface (28) of the insulating housing (26), and in that each winding groove is provided with a conductive groove layer.

IPC Classes  ?

• H01F 30/16 - Toroidal transformers
• H01F 27/28 - CoilsWindingsConductive connections
• H01F 27/30 - Fastening or clamping coils, windings, or parts thereof togetherFastening or mounting coils or windings on core, casing, or other support
• H01F 27/32 - Insulating of coils, windings, or parts thereof

Abstract

The invention relates to a method for characterising the quality of an X-ray beam having a known profile for depositing a dose in a body, having an zone (Za1, Za2) of increasing dose rate inside said body extending between the input surface of the beam and a characteristic depth (Pmax) where the deposited dose is at a maximum, the method comprising the following steps: - providing a monolithic detector including m p-n junctions (m ᡶ 3) stacked depth-wise in the detector with at least three junctions distributed in the zone of increasing dose rate; - projecting said X-ray beam onto the monolithic detector; - recovering the m signals (r) delivered by the p-n junctions of the detector; - and processing the m signals (r) in order to characterise the quality of the X-ray beam.

IPC Classes  ?

• G01T 1/24 - Measuring radiation intensity with semiconductor detectors
• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation

Abstract

The invention relates to a product intended for the preparation of an injectable composition containing, separated from one another, at least one first and one second composition(s), and in which: - the first composition, referred to as A, is an aqueous solution of chitosan with a pH in the range extending from 3 to 7, and - the second composition, referred to as B1, corresponds to particles of one or more bioactive glass(es), said product not containing glycerophosphate; and also a process for preparing an injectable composition, the corresponding injectable compositions and devices for packaging a product according to the invention.

IPC Classes  ?

• A61L 27/10 - Ceramics or glasses
• A61L 27/20 - Polysaccharides
• A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
• A61L 27/58 - Materials at least partially resorbable by the body

Goods & Services

Biological analysis software; muscle cut image analysis software; cell image analysis software; analysis software of biological tissues; composite material image analysis software; nano-material image analysis software. Biological analysis services; online biological analysis services; researches in the field of biology; installation of biological analysis software; consulting relating to biological analysis software; developing [design] of biological analysis software; maintenance of biological analysis software; updating of biological analysis software; analysis services in the field of composite materials; on-line analysis services in the field of composite materials; researches in the field of composite materials; installation of analysis software in the field of composite materials; consultancy relating to analysis software in the field of composite materials; developing [design] of analysis software in the field of composite materials; maintenance of analysis software in the field of composite materials; updating of analysis software in the field of composite materials; analysis services in the field of nano-materials; on-line analysis services in the field of nano-materials; researches in the field of nano-materials; installation of analysis software in the field of nano-materials; consultancy relating to analysis software in the field of nano-materials; developing [design] of analysis software in the field of nano-materials; maintenance of analysis software in the field of nano-materials; updating of analysis software in the field of nano-materials. Analysis of medical images; on-line services for the analysis of medical images.

Abstract

The invention relates to cationic complexes made up of a lanthanide ion Ln3+ and a ligand of formula (I) with X, Y and R1 as defined in claim 1, and to the salts thereof with an anion, the solvates and hydrates thereof; with the exception of cationic complexes made up of a lanthanide ion Ln3+ and a ligand of one of formulae (1.1) or (1.4) as defined in claim 1, and the salts, solvates and hydrates thereof. The invention also relates to the use of such a complex or of a cationic complex made up of a lanthanide ion Ln3+ and a ligand of formula (1.1) or (1.4) as defined in claim 1, or of one of the salts thereof with an anion, the solvates or hydrates thereof, as an aid to the crystallisation of a biological macromolecule, as well as to crystallisation methods and methods for analysing or determining the structure of a biological macromolecule.

IPC Classes  ?

• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
• G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• B01D 9/00 - Crystallisation

Abstract

The invention provides probes with formula (I): as well as their physiologically acceptable salts, solvates, or hydrates. The invention also provides intermediates for the synthesis thereof and detection methods employing them.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
• C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 403/08 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing alicyclic rings
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 241/04 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

Abstract

The present invention concerns a process for polarizing 1H, 13C, 15N or another nucleus of an analyte by dissolution dynamic nuclear polarization (D- DNP), said process comprising the successive steps of: i) providing a liquid sample containing the analyte to be polarized; ii) impregnating a porous material carrying radicals with the liquid sample containing the analyte, iii) cooling the impregnated material, at a temperature in the range from 0.5 K to 300 K, iv) submitting the impregnated material in the cooled state obtained in step, iii) to D-DNP conditions to polarize, directly or indirectly, the selected nuclear spin of the analyte, v) warming the impregnated material obtained after step iv) and passing a solution through the material which will carry the polarized analyte with it, wherein the material carrying radicals which is impregnated in step ii) was obtained by incorporating radicals through covaient bonding on an initial existing porous solid, this initial existing porous solid being exclusively inorganic or being a carbon based solid with a content of carbon representing at least 97% of the mass of the initial existing porous solid.

IPC Classes  ?

• G01R 33/28 - Details of apparatus provided for in groups
• G01N 24/12 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using double resonance
• G01R 33/62 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques

Abstract

The invention concerns a material formed by a porous and non-structured network, this network consisting in either Si atoms or Si atoms and metal atoms, linked to each other by linking arms, characterized in that the material comprises organic molecules which include at least one radical and which are covalently bonded to the network or form part of the network, the amount of radicals being in the range of 0.5 to 160 μmol per gram of material, preferentially in the range of 2 to 100 μmol per gram of material, preferentially in the range of 2 to 100 μmol per gram of material and its use as an electron source for dynamic nuclear polarization (DNP), and in particular for dissolution dynamic nuclear polarization (D-DNP).

IPC Classes  ?

• C08L 83/08 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
• G01R 33/28 - Details of apparatus provided for in groups

Abstract

The invention relates to a liquid composition comprising: chlorhexidine digluconate; a colorant of formula (I) in the form a pharmaceutically acceptable salt, wherein R1, R2, R3, R4 are the same or different and each one independently represents a hydrogen atom or a chlorine atom; water and at least one alcohol selected from ethanol, n-propanol and isopropanol. The invention also relates to a method for producing such a composition, to the use thereof as a medicament, in particular for skin antisepsis, and to the use thereof for the disinfection of instruments, particularly before a surgical operation.

IPC Classes  ?

• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 31/02 - Local antiseptics
• A61L 2/18 - Liquid substances

Abstract

The present invention relates to a material (II) containing a matrix (IV) consisting of an inorganic network, in which semiconductor nanoparticles (III) and anisotropic gold nanoparticles (I) are distributed, the semiconductor nanoparticles (III) representing from 30 to 70 wt% of the total weight of the material (II). Said material is characterized in that: the anisotropic gold nanoparticles (I) represent from 0.1 to 10 wt% of the total weight of the material (II), preferably from 0.5 to 5 wt% of the total weight of the material (II), and more preferably from 0.5 to 2 wt% of the total weight of the material (II), and the anisotropic gold nanoparticles (I) have a particular shape as defined in claim 1. The invention also relates to the use of a material according to the invention for photocatalytic breakdown of organic compounds, particularly biological or chemical agents, or for photovoltaic power production, and to a method for preparing such a material.

IPC Classes  ?

• B01J 23/52 - Gold
• B01J 21/06 - Silicon, titanium, zirconium or hafniumOxides or hydroxides thereof
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 35/02 - Solids
• A61L 9/20 - Ultraviolet radiation
• B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures
• H01L 31/0264 - Inorganic materials
• B01J 23/68 - Silver or gold with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
• B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
• B01J 27/04 - Sulfides
• B01J 27/057 - Selenium or telluriumCompounds thereof

Abstract

The invention relates to a compound of formula (I): where X and R are defined in claim i, or a drug or pharmaceutical composition comprising such a compound of formula (I) or any pharmaceutically acceptable hydrates, salts or solvates thereof, in the form of a pure isomer or a mixture of isomers in any proportion, for the use thereof in treating intestinal cancer or intestinal inflammation.

IPC Classes  ?

• C07F 9/10 - Phosphatides, e.g. lecithin
• A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
• A61P 35/00 - Antineoplastic agents
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

The invention proposes a spectrometer facility comprising at least one main optical radiation collector (18, 21, 36) having a main field of vision (CVP) and at least one main optical fibre (18); characterised in that it comprises an aiming system comprising: at least two auxiliary optical radiation collectors (21, 341-343, 36) each having a separate auxiliary field of vision (CVAi), not coincident with the main field of vision, distributed around the main field of vision; for each auxiliary collector, at least one separate auxiliary optical fibre (341-343) and one separate associated photodetector (321-323). The invention also proposes a spectrometry method comprising the comparison of the intensity of the auxiliary optical radiation collected in at least two separate auxiliary fields of vision, not coincident with a main field of vision for collecting characteristic optical radiation.

IPC Classes  ?

• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/44 - Raman spectrometryScattering spectrometry

Abstract

and it also relates to the joint use of cyclosporin A and taxol in a solution for in vitro preservation of an organ, in particular the myocardium.

IPC Classes  ?

• A01N 1/02 - Preservation of living parts
• A61K 38/15 - DepsipeptidesDerivatives thereof
• A61K 51/04 - Organic compounds

Abstract

The present invention relates to a lithography and transfer method including the following consecutive steps: a) a step for depositing at least one biopolymer onto a substrate from an aqueous solution of said biopolymer; b) a step for exposing localized areas of the deposited biopolymer(s) to electromagnetic radiation or to an electron or ion beam in a pattern or series of patterns; c) a development step, causing the removal of the biopolymer(s) on the exposed areas so as to obtain substrate areas that are not covered with biopolymer(s) and that correspond to said pattern or to said series of patterns, which areas are defined by a mask of biopolymer(s); d) a step for transferring the pattern or series of patterns by etching, deposition, and/or implanting onto the areas of the substrate that are not covered by the mask of biopolymer(s); and e) a step for selectively removing the mask of biopolymer(s) deposited onto the substrate, the biopolymer(s) being selected from among chitosan and alginates.

IPC Classes  ?

• G03F 7/039 - Macromolecular compounds which are photodegradable, e.g. positive electron resists

Abstract

The invention relates to the use of at least one proanthocyanidin for limiting denitrification, consisting in the reduction of NO3 in N2O et N2, caused by microorganisms particularly present in an environment, by bringing said at least one proanthocyanidin into contact with said microorganisms.

IPC Classes  ?

• C05F 11/00 - Other organic fertilisers
• C05G 3/08 - Mixtures of one or more fertilisers with materials not having a specifically fertilising activity with agents affecting the nitrification of ammonium compounds or urea in the soil

Abstract

The invention relates to a process for treating a liquid effluent comprising an organic pollutant, said process producing electrical energy, characterized in that: the liquid effluent has a pH belonging to the range extending from 2 to 4 and contains aqueous hydrogen peroxide solution, at least one anode and one cathode are submerged in the liquid effluent and are connected to one another by an electrical circuit, said at least one anode being capable of generating Fe2+ ions by galvanic corrosion and said at least one cathode being made of a material more noble than the constituent material of the anode, Fe2+ ions are generated at the anode by galvanic corrosion and react, according to the Fenton reaction, with the aqueous hydrogen peroxide solution present in the liquid effluent, in order to form HO radicals that lead to the degradation, by oxidation, of the organic pollutant present in the effluent and the production of electrical energy, the electrical energy generated is recovered, and also to a device for the implementation of such a process.

IPC Classes  ?

• C02F 1/72 - Treatment of water, waste water, or sewage by oxidation
• H01M 14/00 - Electrochemical current or voltage generators not provided for in groups Manufacture thereof

Abstract

The present invention relates to a peptide comprising an amino acid sequence at least 85% identical to the amino acid sequence as shown in SEQ ID NO. 1, wherein the residues Lys905, Arg909, and Arg912 contained therein are present, for use as a medicament, in particular for its use as an inhibitor of FGF-2 induced angiogenesis.

IPC Classes  ?

• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Abstract

The invention concerns an assembly consisting of a substrate on which at least one lipid bilayer is attached by means of a peptide, referred to as the tethering peptide, which is itself linked to the substrate, characterised in that the tethering peptide has a C-terminal end constituted by at least four consecutive histidines and in that the lipid bilayer comprises a portion of lipids having a chelating headgroup enclosing a metal cation providing the link with the tethering peptide as a result of metal-chelate interactions between the metal cation and at least a portion of the histidines located at the C-terminal position of the tethering peptide; and the method for preparing same and the associated detection methods.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 21/552 - Attenuated total reflection
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention concerns materials consisting in a porous and structured network, this network being at least in part formed by Si atoms, or Si atoms and metal atoms, linked to each other by oxy bridges, comprising organic molecules which include at least one nitroxyl radical -NO· and which are covalently bonded to the network via siloxy bonds, the amount of nitroxyl radical -NO· ranging from 30 to 120 nmol per square meter of material characterized in that : Q > 0.4 and 4s < T1a < T1b < 800s, with Q, T1a * and T1b being obtained by the method defined in claim 1.

IPC Classes  ?

• C08L 83/08 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
• G01R 33/28 - Details of apparatus provided for in groups

Abstract

The present invention relates to luminescent lanthanide complexes including a chelating agent, formed with a macrocycle or a set of ligands, complexing a lanthanide ion Ln3+, wherein the chelating agent is substituted with at least two groups. The invention is most particularly applied to lanthanide complexes, the chelating agent of which is formed the with three ligands integrating a 2,6 pyridine-di(carboxylic acid) or is formed with a macrocycle having a 1,4,7 triazacyclononane structure.

IPC Classes  ?

• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
• C09K 9/02 - Organic tenebrescent materials
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 213/79 - AcidsEsters
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 255/02 - Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups not condensed with other rings
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

The invention relates to the probes of formula (I); in which: X1 = NH, O or S; X2 = O or S; SE is a labile group, which may be removed under the action of a stimulus which may in particular be the presence of an enzyme, of a chemical compound or of a physicochemical characteristic of the medium containing the probe; A is an aromatic group, which, after cleavage of the C(X2)-O, linkage in aqueous solution, results in the release of a chomophore or a flurophore; R is a hydrogen atom or -(L)n-GP, in which n is equal to 0 or 1, L is a link arm, GP is a hydrosolubilizing group, and also the physiologically acceptable salts, solvates or hydrates thereof. The subject matter of the invention is also the intermediates for the synthesis thereof and the detection methods using same.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• C07D 311/04 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring
• C07D 239/72 - QuinazolinesHydrogenated quinazolines
• C07D 249/04 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Abstract

The present invention relates to a method for producing borazane (NH3-BH3). The method includes: providing a reactor (1), provided with stirring means and a thermostat set to a temperature of θ1 to 40 °C; injecting anhydrous liquid ammonia (NH3(l)) into said reactor (1); injecting a borane-amine complex (Am.BH3) into said reactor (1) containing the anhydrous liquid ammonia (NH3(l)) while stirring, wherein said borane-amine complex (Am.BH3), the corresponding amine (Am) of which is only soluble in anhydrous liquid ammonia at a rate of less than 10 g in 100 g of ammonia at 20 °C, is injected in an amount such that the molar ratio R = anhydrous liquid ammonia (NH3(l)) / borane-amine complex (Am.BH3) is no lower than 5; stirring the mixture; halting the stirring and obtaining, within said reactor (1), two demixed phases: a light phase (1a) made up essentially of an anhydrous liquid ammonia solution (NH3(l)) containing borazane, and a heavy phase (1b) made up essentially of the amine (Am) corresponding to the injected borane-amine complex (Am.BH3); isolating said borazane and vacuum drying same; said temperature θ1 being no lower than the melting temperature of said borane-amine complex (Am.BH3).

IPC Classes  ?

• C01B 35/14 - Compounds containing boron and nitrogen, phosphorus, sulfur, selenium or tellurium
• C07F 5/02 - Boron compounds

Abstract

A device for characterizing a fluid medium with the help of a photoelectric transducer comprises at least one semiconductor substrate possessing at least one space charge zone and presenting a reception surface for receiving the fluid medium in order to constitute an interface between the substrate and the fluid medium, a production system for producing a spot light beam that is amplitude-modulated and that lights at least one zone of the interface through the fluid medium, a measurement system for measuring values of a photoelectric magnitude delivered while performing the lighting so as to create a matrix of values of the photoelectric magnitude, and a processor system for processing values of the photoelectric magnitude delivered by the measurement system and adapted to use the matrix to determine an electronic signature characteristic of the fluid medium.

IPC Classes  ?

• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated

Abstract

The invention relates to the use of a dicarboxylic acid comprising 2 to 5 carbon atoms to control the growth of holo- or hemiparasitic plants, as well as to the strain Azospirillum brasilense L4, registered with CNCM (Collection Nationale de Cultures de MicrOorganismes, France) under number I-4830, capable of producing a dicarboxylic acid exhibiting a bioherbicidal activity against Striga and Orobanche.

IPC Classes  ?

• A01N 37/04 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof polybasic
• A01N 37/06 - Unsaturated carboxylic acids or thio-analogues thereofDerivatives thereof
• A01N 37/36 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio-analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
• A01N 63/02 - Substances produced by, or obtained from, microorganisms or animals
• A01P 13/02 - HerbicidesAlgicides selective
• A01P 21/00 - Plant growth regulators

Abstract

The invention concerns a new class of tubulin polymerisation inhibitors and their applications in research and medicine, notably in chemotherapy. The invention proposes new azoaryl derivatives of formula (I): as defined in Claim 1, which may be fully reversibly interconverted between non-tubulin-binding trans and tubulin-binding cis isomeric forms, either by irradiation or spontaneously. The invention also concerns compounds with a azoaryl structure for use in studying the cytoskeleton and/or its associated processes, or in the treatment of a disease for which a tubulin polymerisation inhibition activity has a beneficial effect, wherein the compound is administered to the cell, organism or patient in need of such treatment in the trans form of the diazenyl bond, and where this trans form is inactive as regards a tubulin polymerisation inhibition effect, and where after photoisomerisation in vitro, in cellulo or in vivo to an azoaryl compound in its cis isomeric form of the diazenyl bond by the application of light, optionally with modification in vitro, in cellulo or in vivo of one or more substituents, the resultant cis form is active as regards a tubulin polymerisation inhibition effect.

IPC Classes  ?

• C09B 29/01 - Monoazo dyes prepared by diazotising and coupling characterised by the diazo component
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• C09B 29/08 - Amino benzenes

Abstract

The invention concerns novel glycosidase substrates of formula (I): and a method for detecting the presence of a catalytically active glycosidase using one of these substrates.

IPC Classes  ?

• C12Q 1/40 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving amylase
• C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase

Abstract

The invention pertains to the field of jewellery, especially nacreous pearls used in jewellery. Said invention especially relates to the development of a method for marking and/or labelling cultured pearls. The invention more generally relates to a method for marking a solid comprising at least a nacre coating, said method comprising the immersion of said solid in an aqueous solution comprising a tracer which is photoluminescent in the presence of said solid for a sufficient amount of time to allow the fluorescent tracer to adhere to the nacre coating.

IPC Classes  ?

• G01N 21/87 - Investigating jewels
• G01N 21/64 - FluorescencePhosphorescence
• A44C 27/00 - Making jewellery or other personal adornments
• G01N 21/84 - Systems specially adapted for particular applications

Abstract

The present invention relates to chitosan hydrogel microparticles of a median size d50 comprised between 1 and 500 μm (obtained from a number distribution), the chitosan having a degree of acetylation of less than equal to 20% and its concentration in the hydrogel being comprised between 0.25 and 5% by weight based on a total weight of the hydrogel, for use in neuron regeneration and/or in the repair of the nervous system, advantageously of the central nervous system, and/or in the grafting of neurons and/or in the treatment of neurodegenerative diseases and/or in the treatment of paralyses. It also relates to an implant comprising an aqueous suspension of microparticles mixed with Schwann cells and/or stem cells and/or trophic factors.

IPC Classes  ?

• A61K 31/722 - ChitinChitosan
• A61L 27/20 - Polysaccharides
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/38 - Animal cells
• A61L 27/50 - Materials characterised by their function or physical properties
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The spinal correction system has two bone-anchoring devices (2a), (2b) connected to each other by a stabilization system (3). A bone-anchoring device (2a) comprises a support (7), on which are fixed the fixation heads (6) that define between them a longitudinal axis, said support (7) comprising a connector element (7b) for connection to the stabilization system (3), said connector element (7b) extending on a first axis of rotation orthogonal to the longitudinal axis and being connected to the stabilization system (3) in such a way that the latter is offset from said fixation heads (6). According to the invention, the stabilization system (3) is mounted freely in rotation on the connector element (7b) of the first device at least around the first axis of rotation and has a system for blocking in translation with respect to said connector element (7b).

IPC Classes  ?

• A61B 17/70 - Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant

Abstract

The present invention concerns an implant for tissue regeneration in the form of a colorectal patch or a vascular substitute, characterised in that it consists at least partly of a physical chitosan hydrogel having a degree of acetylation (DA) less than or equal to 15%, characterised in that parameter P, corresponding to the product of the weight average molecular mass Mw of chitosan expressed in kg/mol multiplied by the concentration of chitosan in the hydrogel expressed as a mass % relative to the total mass of the hydrogel, is greater than or equal to 1500 %.kg/mol.

IPC Classes  ?

• A61L 27/20 - Polysaccharides
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

An aerodynamic system designed to be arranged near at least one rear edge (2, 42, 43) of a box-shaped rear portion of a vehicle (3). The aerodynamic system (1) comprises, in the operative position: at least one gas jet generating system (12) able to generate jets of gas (17); at least one outer surface (45) along which air flow generated by at least the forward motion of the vehicle is flowing; at least one opening which opens onto the outer surface (45) and which is connected to said at least one gas jet generating system (12) in order to blow jets of gas (17) in the atmosphere and to influence said air flow. The opening (16) being designed and/or oriented to blow jets of gas (17) rearward. The outer surface (45) comprises at least a guiding surface (20) extending at least partially downstream from said opening (16) and oriented inwards from front to rear, in order to guide said influenced air flow downstream from the opening (16). The gas jet generating system (12) is designed to discontinuously generate jets of gas (17) at a frequency F that is higher than 100 Hz, that is preferably comprised between 200 Hz and 1000 Hz and more preferably between 200 Hz and 450 Hz.

IPC Classes  ?

• B62D 35/00 - Vehicle bodies characterised by streamlining
• B62D 37/02 - Stabilising vehicle bodies without controlling suspension arrangements by aerodynamic means

Abstract

The present invention relates to a process for producing a device comprising a porous monolith confined in a microfluidic circuit, said porous monolith comprising at least two distinct zones, including at least one zone (Z) bearing a functionality R bonded to the porous monolith by a covalent bond and obtained by virtue of photografting with the use of a pair of functions X and Y defined as follows: - either X is a function comprising an abstractible hydrogen, chosen from -SH functions, -OH functions, alkylamine functions having a hydrogen atom, borne by a carbon in the alpha position with respect to the nitrogen atom, and ether functions having a hydrogen atom borne by a carbon in the alpha position with respect to the oxygen atom, and Y comprises an unsaturation; - or X comprises an unsaturation and Y is a function comprising an abstractible hydrogen, chosen from -SH functions, -OH functions, alkylamine functions having a hydrogen atom, borne by a carbon in the alpha position with respect to the nitrogen atom, and ether functions having a hydrogen atom borne by a carbon in the alpha position with respect to the oxygen atom.

IPC Classes  ?

• B01J 20/32 - Impregnating or coating
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography

Abstract

The invention relates to an aqueous solution for preserving an organ, especially the myocardium, comprising: between 100 and 130 mM of Na+, between 12 and 15 mM of K+, between 0.25 and 13 mM of Ca++, between 0.5 and 1.5 μΜ of cyclosporin A, and between 0.5 and 1.5 μΗ of taxol, and to the combined use of cyclosporin A and taxol in a solution for the in vitro preservation of organs, especially the myocardium.

IPC Classes  ?

• A01N 1/02 - Preservation of living parts

Abstract

2 adsorption at a low temperature, the catalyst being a catalyst comprising at least one supported or non-supported lanthanide oxide or a molecular sieve based on silicon containing the organic template thereof. The invention also relates to a method for preparing HMF from glucose, comprising the isomerization of glucose into fructose.

IPC Classes  ?

• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07D 307/46 - Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
• C07H 3/02 - Monosaccharides

Abstract

A method for assessing the effectiveness of a hearing aid. Said method involves: transmitting out a stimulus via a hearing aid, thereby supplying an auditory stimulus to the auditory nervous system of a person provided with said hearing aid; receiving the neurophysiological signals emitted by said auditory nervous system in response to the auditory stimulus by means of an electro- or magneto-encephalography system; processing the received signals; sending out a stimulus consisting of at least one pair of linguistic units selected from a phonetic confusion matrix; separately receiving a neurophysiological signal in response for each linguistic unit; and comparing the signals such as to assess the effectiveness of the hearing aid.

IPC Classes  ?

• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
• A61B 5/0484 - Electroencephalography using evoked response
• A61B 5/12 - Audiometering
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• H04R 25/00 - Deaf-aid sets

Abstract

The present invention concerns the cosmetic use, by topical administration, of an extract of Tapirira guianensis, for stimulating the expression of perlecan and/or dystroglycan and/or VE-cadherin and/or claudin-5, in particular in the extracellular matrix and/or in the epithelial basement membrane, in particular the dermoepidermal junction. It also concerns a method of cosmetic treatment comprising the application onto at least one area in question of healthy skin and/or healthy mucosa and/or healthy scalp of an extract of Tapirira guianensis or of a cosmetic composition comprising such an extract for stimulating the expression of perlecan and dystroglycan and/or VE-cadherin and/or claudin-5, in particular in the extracellular matrix and/or in the epithelial basement membrane, in particular the dermoepidermal junction. It also concerns a cosmetic composition comprising an extract of Tapirira guianensis and a topically acceptable cosmetic carrier. It finally concerns an extract of Tapirira guianensis or a dermatological composition containing an extract of Tapirira guianensis and a dermatologically acceptable carrier for use, by topical administration, in the treatment and/or prevention of rosacea, des telangiectasias, and/or pathologies of the oral and/or ocular mucosa.

IPC Classes  ?

• A61Q 19/08 - Anti-ageing preparations
• A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
• A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines

Abstract

The present invention relates to a prognosis method for a patient suffering from cancer, which involves in particular determining the course of the cancer and/or the effectiveness of a treatment within the framework of tracking the condition of the patient, including the following steps: measuring the isotopic ratio between two stable isotopes of a chemical element selected from among copper and zinc in a biological sample to be tested, which was taken from said patient; comparing said isotopic ratio with that which was measured in a reference sample; concluding the prognosis about said cancer in said patient on the basis of the variation in the isotopic ratio.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH

Abstract

− are as defined in Claim 1, and also the methods for labelling oligonucleotides using such a derivative, labeling substrates and the oligonucleotides which can be obtained by means of such methods or from such labelling substrates.

IPC Classes  ?

• C07D 279/18 - [b, e]-condensed with two six-membered rings
• C07F 9/6547 - Six-membered rings condensed with carbocyclic rings or ring systems
• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• C09B 21/00 - Thiazine dyes

Abstract

Staphylococcus aureus with a specific mass spectrometry technique allowing specific detection on the obtained mass spectrum of the presence or of the absence of a peak at an m/z value of 3005±5 Th Thomson or at 3035±5 Th Thomson, and accordingly, to the issuance of a decision conditioned by this result.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• C12Q 1/14 - StreptococcusStaphylococcus
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• H01J 49/40 - Time-of-flight spectrometers

Abstract

The invention relates to a sublimation head (F) for subliming an electroconductive wire element (4) held between at least two grip bodies (6, 8), said wire element (4) being at least partially sublimable during the electrical connection of the grip bodies (6, 8) with a sublimation station. The sublimation head (F) comprises a frame (1) having a station (14) for collecting the wire element (4) guided to said collection station (14) from a store (16), an assembly (18) which is rotatably mobile about the axis thereof and provided with the at least two bodies (6, 8) for gripping the wire element (4), said grip bodies (6, 8) being positioned on the assembly (18) in order to collect the wire element (4) at the collection station (14), and a system for the activation or deactivation of the grip of the grip bodies (6, 8) in order to activate the gripping of the wire element (4) by the grip body.

IPC Classes  ?

• C23C 14/26 - Vacuum evaporation by resistance or inductive heating of the source
• C30B 23/06 - Heating of the deposition chamber, the substrate, or the materials to be evaporated
• C23C 14/24 - Vacuum evaporation

Abstract

The invention relates to a method for preparing furfural by reacting pentose in water and in the presence of carboxylic acid and of a heterogeneous acid catalyst, the method being conducted in an aqueous solution of carboxylic acid as a reaction medium. The present invention also relates to the preparation of furfural by reaction of pentose in water and in the presence of carboxylic acid and of a heterogeneous acid catalyst. The invention also relates to an aqueous solution of carboxylic acid rich in furfural.

IPC Classes  ?

• C07D 307/48 - Furfural
• C07D 307/50 - Preparation from natural products

Abstract

The present invention relates to a method for depositing a photocatalytic coating onto a substrate, including the following steps: a) providing an aqueous and/or alcoholic solution of nanoparticles of a semiconductor material; b) providing a sol in an aqueous and/or alcoholic solution of a hydrolysed organosilane; c) mixing the suspension and the sol and proceeding with the deposit of the resulting mixture onto the substrate to be coated; d) performing a drying operation; e) and optionally illuminating the coating obtained after drying at at least one wavelength leading to the activation of the semiconductor material, such as to remove at least 3% of the organic groups initially present in the coating and bonded to the silicon atoms by Si-C bond. The invention also relates to coatings having photocatalytic properties, to materials — in particular textiles — covered with such a coating and to the use of such coatings and materials for photocatalysis.

IPC Classes  ?

• B05D 3/06 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• B05D 5/00 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
• B01J 35/02 - Solids
• B05D 3/02 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
• D06M 15/643 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicon in the main chain

Abstract

The present invention concerns compounds of formula (I); in which; - R2, R4 and R6, identical or different, represent a hydrogen, chlorine, bromine, iodine or fluorine atom, or an -OH or -O-alkyl group comprising 1 to 6 carbon atoms; -R2 and R4, identical or different, represent a hydrogen atom, or an --OH or -Q-alkyl group comprising 1 to 6 carbon atoms; in which R2' and/or R4' represent(s) a methoxy group; - n is equal to 1, 2 or 3; - X = CH2, G, S or N(R7); and - R7 represents a hydrogen atom or an alkyl group comprising 1 to 6 carbon atoms; and the pharmaceutically acceptable hydrates, solvates and salts thereof.

IPC Classes  ?

• C07D 211/22 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms by oxygen atoms
• A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
• A61P 37/08 - Antiallergic agents

Abstract

The invention relates to luminescent lanthanide complexes comprising a chelating agent, formed by a macrocycle or a set of ligands, complexing a lanthanide ion Ln3+, characterised in that the chelating agent is substituted with at least two groups. More specifically, the invention relates to lanthanide complexes having a chelating agent formed by three ligands incorporating a 2,6- pyridine-diacid carboxylic group or formed by a macrocycle having a 1,4,7- triazacyclononane structure.

IPC Classes  ?

• C09K 9/02 - Organic tenebrescent materials
• A61K 49/00 - Preparations for testing in vivo
• C07D 257/02 - Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
• C07D 213/24 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present invention relates to the topical cosmetic use of a Polygonum bistorta extract for stimulating the expression of perlecan and/or dystroglycan, in particular in the extracellular matrix and/or in the epithelial basement membrane, especially the dermoepidermal junction. It also relates to a cosmetic care method comprising the application, to at least one concerned area of healthy skin and/or healthy mucous membrane and/or healthy scalp, of a Polygonum bistorta extract or of a cosmetic composition comprising such an extract for stimulating the expression of perlecan and of dystroglycan, in particular in the extracellular matrix and/or in the epithelial basement membrane, especially the dermoepidermal junction. It finally relates to a Polygonum bistorta extract or a dermatological composition containing a Polygonum bistorta extract and a dermatologically acceptable excipient for topical use in the treatment and/or prevention of rosacea, telangiectasias, chapping and/or disorders of the buccal and/or ocular mucous membranes.

IPC Classes  ?

• A61Q 19/00 - Preparations for care of the skin
• A61Q 19/08 - Anti-ageing preparations
• A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof

Abstract

The invention concerns a measuring device for magnetic resonance applications comprising: - in a measurement housing (12) : • a sensor (15) for measuring radio-frequency magnetic fields, • a sensor (20) for measuring magnetic field gradients, • a sensor (40) for measuring the radio-frequency electric field, • a stage for converting the electrical signals delivered by the various measurement sensors into light signals, - a unit for controlling and processing the signals, linked to the conditioning stage of the measurement housing (12) via a beam for transmitting the light signals (13), said unit comprising a stage for converting the light signals into electrical signals delivered by the sensors.

IPC Classes  ?

• G01R 33/24 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux
• G01R 33/565 - Correction of image distortions, e.g. due to magnetic field inhomogeneities

Abstract

The invention concerns a method for characterising a fluid medium (3) using a semi-conductive substrate (2). According to the invention, the method comprises the following steps: - producing a receiving surface (6) for the fluid medium (3) on at least one face of the substrate (2), - bringing the fluid medium to be characterised into contact with the receiving surface (6), in order to produce a substrate/fluid medium interface (7), - illuminating, through the fluid medium (3), at least one area of the interface (7) using a pulsed light beam (9) to create photogenerated electrical charges, - using a microwave reflectometer (10) to measure the lifetime of the photogenerated electrical charges of which the value depends on the recombination rate at the substrate/fluid medium interface (7), - creating a matrix of the values of the measured lifetimes of the photogenerated electrical charges, - determining an electronic signature characteristic of the fluid medium from the created matrix of lifetimes.

IPC Classes  ?

• G01N 22/00 - Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated

Abstract

The invention concerns a device for characterising a fluid medium (3) using a photoelectric transducer (2). According to the invention, the device comprises: at least one semi-conductive substrate (4) having at least one space charge region {5} and having a receiving surface (6) for the fluid medium with a view to forming a substrate/fluid medium interface (7); a system (8) for producing an amplitude-modulated point light beam (9) that illuminates, through the fluid medium (3), at least one area of the interface (7), a system (10) for measuring the values of a photoelectric magnitude delivered during the illumination in order to create a matrix of the photoelectric magnitude values, and a system (12) for processing the photoelectric magnitude values delivered by the measurement system (10), designed to determine, from the matrix, an electronic signature characteristic of the fluid medium.

IPC Classes  ?

• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated

Abstract

The present invention concerns a device for producing electrical energy comprising two cells intended to contain two solutions of different concentrations of at least one solute and separated by at least one separation membrane in which channels are arranged, each of the cells being provided with an electrode intended to be in contact with the solution that said cell will contain, characterised in that the walls of the channels consist of a material chosen from boron nitride, carbon doped with boron, boron nitride doped with carbon, or any other mixture of the elements boron, carbon and nitrogen, and a method for producing electrical energy that implements such a device.

IPC Classes  ?

• F03G 7/00 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for
• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 61/06 - Energy recovery
• B01D 61/42 - ElectrodialysisElectro-osmosis
• H01M 8/22 - Fuel cells in which the fuel is based on materials comprising carbon or oxygen or hydrogen and other elementsFuel cells in which the fuel is based on materials comprising only elements other than carbon, oxygen or hydrogen

Abstract

The invention concerns a spectroscopic measurement device comprising: - a system (2) for focusing a laser beam (3) on a sample to be analysed (4), - a system for collecting and spectroscopically analysing (17) the light rays emitted by the plasma (15), the system for collecting and analysing (17) comprising, in particular, an optic fibre (18) for collecting light. According to the invention, the device comprises: - a motorised system (23) for moving the optic fibre (18), - an optical imaging system (25) for imaging the plasma, in image form, - and a processing and control unit (24) comprising: • means for analysing the image formed by the optical imaging system in order to select an area of interest, • means for controlling the motorised system (23) in order to position the optic fibre in a position enabling it to collect light coming from the selected area of interest of the plasma.

IPC Classes  ?

• G01N 21/71 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited

Abstract

The present invention concerns materials consisting in a porous and structured network, this network being at least in part formed by Si atoms, or Si atoms and metal atoms, linked to each other's via siloxy bonds, the amount of radical ranging from 0.50 to 0.03 mmol of radical per gram of material, and in that the network is formed with a sol-gel step using an organosilane for the introduction of the organic molecules allowing their regular distribution within the porous structured material. The invention also concern a process for the preparation of such material and a method of analysis by Nuclear Magnetic Resonance (NMR) of an analyte wherein it uses dynamic nuclear polarization generated with a material according to the invention.

IPC Classes  ?

• G01R 33/28 - Details of apparatus provided for in groups
• C08L 83/04 - Polysiloxanes

Abstract

The present invention concerns complexes of formula (I) as defined in claim 1, and such complexes for the in vivo detection by MRI of a chemical or biochemical stimulus resulting in the reduction of an -NO?. function, and a method for the in vitro detection of a chemical or biochemical stimulus resulting in the reduction of an -NQ2 function present in the complexes of formula (I).

IPC Classes  ?

• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• C07F 15/02 - Iron compounds
• A61K 49/10 - Organic compounds
• A61P 35/00 - Antineoplastic agents

Abstract

The invention concerns novel glycosidase substrates of formula (I); in which R0, R1, R2, R3 and R4 are as defined in claim 1, and a method for detecting the presence of a catalytically active glycosidase by means of one of said substrates.

IPC Classes  ?

• C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
• A61K 49/00 - Preparations for testing in vivo
• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase

Abstract

The present invention relates to microparticles of chitosan hydrogel having a median size d50 of 1 to 500 pm (obtained from a number distribution), the chitosan having an acetylation degree no higher than 20 % and the concentration thereof in the hydrogel being 0.25 wt % to 5 wt % relative to the total weight of the hydrogel, for use in nerve-cell regeneration and/or in repairing the nervous system, advantageously the central nervous system, and/or in grafting nerve cells and/or in the treatment of neurodegenerative diseases and/or in the treatment of paralysis; the invention further relates to an implant including an aqueous suspension of microparticles mixed with Schwann cells and/or stem cells and/or trophic factors.

IPC Classes  ?

• A61L 27/20 - Polysaccharides
• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

The present invention relates to novel pyrrolidine derivatives of formula (I), where R1, R2, R3, R4, R5 and X are as defined in claim 1, optionally in zwitterionic form, in the form of a pure optical isomer, or in the form of a mixture of optical isomers in any proportion, or in a form enriched with an optical isomer, as well as to the pharmaceutically acceptable salts, solvates, or hydrates thereof, and to the pharmaceutical compositions containing said compounds. Said compounds are useful in particular for the treatment, in particular in human beings, of epilepsy, ischaemia, neurodegenerative diseases, such as Parkinson's disease or Huntington's disease, multiple sclerosis, Devic's disease and Alzheimer's disease, and psychiatric disorders such as schizophrenia, depression, addiction, allodynia, and hyperalgesia.

IPC Classes  ?

• C07D 207/12 - Oxygen or sulfur atoms
• A61K 31/401 - ProlineDerivatives thereof, e.g. captopril
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The present invention relates to a method for detecting and/or quantifying Naegleria fowleri, in particular by real-time PCR or qPCR, to specific oligonucleotides for performing such a detection and/or quantification, such as probes and primers, as well as to devices or kits containing same.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The invention relates to an improved process/device for purification treatment, by photocatalysis, of aqueous liquid effluents comprising at least one pollutant. In this process: (a) a suspension consisting of the effluent to be treated and loaded with particles of a photocatalyst is used and/or prepared; (b) the suspension of effluent to be treated, loaded with photocatalyst particles, is circulated in a reactor which has an inlet and an outlet and which comprises at least two zones; (c) a stream of air bubbles is diffused within the suspension circulated; (d) a photoactivation is carried out using irradiation means placed in the reactor; (e) the liquid phase is separated from the solid phase of the treated effluent by filtration; (f) then this liquid phase of the treated effluent is recovered. This process is characterized in that (i) the reactor used comprises at least two zones; (ii) it is seen to that the stream of gas bubbles is diffused within only one of the two zones: the aerated zone, and generates a gas lift which makes it possible to obtain recirculation between the two zones and hydrodynamic behaviour of perfectly stirred reactor (PSR) type.

IPC Classes  ?

• C02F 1/32 - Treatment of water, waste water, or sewage by irradiation with ultraviolet light
• C02F 1/72 - Treatment of water, waste water, or sewage by oxidation
• C02F 101/30 - Organic compounds

Abstract

The present invention concerns particles consisting of a solid hydrophobic matrix in which the droplets of an aqueous dispersion of an adhesive compound are distributed, method for obtaining same and use thereof.

IPC Classes  ?

• C09J 9/00 - Adhesives characterised by their physical nature or the effects produced, e.g. glue sticks

Abstract

The invention relates to a novel use of ultrafine nanoparticles, which are of use as a diagnostic, therapeutic or theranostic agent, characterized by the mode of administration thereof via the airways. The invention is also directed towards the uses which follow from this new mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of lung diseases. In the therapeutic field, the uses envisaged are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), for neutron therapy, and of agents for PDT (photodynamic therapy), in particular for treating lung tumours.

IPC Classes  ?

• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/10 - Organic compounds
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

Abstract

The current invention is directed to particulate or vesicular immunomodulators, like e.g. cytokines, for use in combination therapy with antibodies for treatments of a range of 10 conditions and diseases, in particular cancer, as well as methods, compositions, and kits thereof.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/50 - Microcapsules
• A61K 9/51 - Nanocapsules
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to diaminophenothiazinium derivatives of formula (I); in which R1, R2, R3, R4, R5, R6 and X are as defined in Claim 1, and also the methods for labelling oligonucleotides using such a derivative, labelling substrates and the oligonucleotides which can be obtained by means of such methods or from such labelling substrates.

IPC Classes  ?

• C07D 279/18 - [b, e]-condensed with two six-membered rings
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C09B 49/06 - Sulfur dyes from azines, oxazines, thiazines, or thiazoles

Abstract

The present invention relates to a continuous spinning method for manufacturing a thread consisting of an assembly of continuous filaments, including the following sequential steps: a) electrospinning, through a first die comprising a series of tubular elements, a first series of polymeric filaments, and electrospinning, through a second die which comprises a series of tubular elements and which is subjected to a polarization voltage different from that to which the first die is subjected, a second series of polymeric filaments, the two series of tubular elements being arranged and oriented such that the two series of filaments outputted from the tubular elements are joined and combined together; and b) continuously recovering and drawing the thread formed by the assembly of the two series of filaments which are attracted to each other due to the polarities thereof, wherein the tubular elements of each of the dies are oriented in parallel in a substantially horizontal direction, and the outlets of the tubular elements of each die are arranged in a plane which extends perpendicularly to the direction of the tubular elements. The invention also relates to the threads that can be produced by such a method, as well as to a device for implementing such a method.

IPC Classes  ?

• D01D 5/00 - Formation of filaments, threads, or the like

Abstract

The invention relates in particular to a method for determining, in vitro, the specific activity of the LPA1 receptor by measuring the expression of the HBEGF and CXCL3 markers, in particular for determining, in vitro, the modulatory activity of a compound specifically with respect to the LPA1 receptor, in particular in the context of monitoring the efficacy of a therapeutic compound specifically targeting the LPA1 receptor.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The invention relates to a method for determining, in vitro, the specific activity of the LPA2 receptor by measuring the expression of one or more specific markers, in particular for determining, in vitro, the modulatory activity of a compound specifically with respect to the LPA2 receptor, in particular in the context of monitoring the efficacy of a therapeutic compound specifically targeting the LPA2 receptor. The markers are CCN1 (CYR61) and CCN2 (CTGF) and, optionally, IL6 and IL8.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The present invention relates to a method for preparing so-called modified hexagonal boron nitride particles with metal nanoparticles attached thereto by stable bonds, comprising the following steps: a) providing a reaction mixture comprising either the metal nanoparticles directly, or a water soluble precursor salt of the metal nanoparticles, urea, hexagonal BN particles, water, and an acid, so as to reduce the pH of the reaction mixture, b) then, stirring and heating the reaction mixture, in such a way as to attach the metal nanoparticles or nanoparticles containing the metal element used in order to obtain the desired metal nanoparticles after treatment, to the BN particles, c) washing the modified boron nitride particles closed in this way, and the modified BN particles which can be obtained according to such a method.

IPC Classes  ?

• C04B 35/583 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on borides, nitrides or silicides based on boron nitride
• C04B 35/628 - Coating the powders
• B01J 13/22 - Coating
• C09C 3/06 - Treatment with inorganic compounds
• C01B 21/064 - Binary compounds of nitrogen with metals, with silicon, or with boron with boron

Abstract

The present invention relates to a substrate which is formed by a material selected from among titanium or one of the alloys thereof and on which at least one polymer, having a biological activity and selected from among chitosan, collagen and the derivatives thereof, is covalently immobilized by means of a bonding entity (EL) forming a peptide bond: -CO-NH-, urea: -NH-C(O)-NH-, or thiourea: -NH-C(S)-NH- on the -MH2 functions present on the polymer prior to the grafting thereof and corresponding to the -NH2 functions present on chitosan or collagen in the natural state, or, in the case of chitosan and the derivatives thereof, forming a urethane bond: -NH-C(O)-O- or thiourethane: -NH-C(S)-O- on the -OH functions present on the polymer prior to the grafting thereof and corresponding to the -OH functions on chitosan in the natural state. The invention also relates to the method for preparing same.

IPC Classes  ?

• A61L 27/34 - Macromolecular materials

Abstract

The present invention relates to the use, as a precursor for the chemical vapour deposition of PtSi at the surface of a support, of at least one organometallic complex of Pt comprising at least: - a ligand having a cyclic structure that comprises at least two non-adjacent C=C double bonds, or two ligands having a cyclic structure that each comprise a C=C double bond; and - a ligand chosen from *O-Si(R)3 and *N-(Si(R')3)2, with: the R units being chosen, independently of one another, from (C1-C4)alkoxy groups; the R' units being chosen, independently of one another, from (C1-C4)alkyl and (C3-C4)cycloalkyl groups; and * representing the coordination of the ligand to the platinum.

IPC Classes  ?

• H01M 4/92 - Metals of platinum group
• H01M 4/88 - Processes of manufacture
• C23C 16/42 - Silicides

Abstract

The invention relates to a construction in the form of a box delimiting on the inside: - an inlet chamber connected to an inlet (6) for effluents and comprising a progressive widening, a system for dissipating energy (13) and a decantation area, - a measurement chamber communicating with the inlet chamber via a flow passage extending above a step (16) that extends inside the measurement chamber via a lateral weir. The measurement chamber that is connected to an outlet (7) for effluents is fitted with a measurement device (28) comprising at least one sensor for measuring the flow and the quality of the effluents at the bell-mouthed lateral weir.

IPC Classes  ?

• G01F 1/00 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
• E03F 5/12 - Emergency outlets

Abstract

and the material obtainable by such a method.

IPC Classes  ?

• C08L 83/00 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon onlyCompositions of derivatives of such polymers
• C03C 14/00 - Glass compositions containing a non-glass component, e.g. compositions containing fibres, filaments, whiskers, platelets, or the like, dispersed in a glass matrix
• C03B 19/12 - Other methods of shaping glass by liquid-phase reaction processes
• C01B 33/158 - PurificationDryingDehydrating
• C01B 33/16 - Preparation of silica xerogels
• C01B 33/157 - After-treatment of gels
• C03C 1/00 - Ingredients generally applicable to manufacture of glasses, glazes or vitreous enamels
• C01B 33/145 - Preparation of hydroorganosols, organosols or dispersions in an organic medium
• C01B 33/146 - After-treatment of sols
• C01B 33/155 - Preparation of hydroorganogels or organogels
• C07F 7/21 - Cyclic compounds having at least one ring containing silicon but no carbon in the ring

Abstract

The present invention relates to a method for studying a sample containing a bacterial population of Staphylococcus aureus using a specific mass spectrometry technique which enables the specific detection, on the mass spectrum obtained, of the presence or absence of a peak with an m/z value at 3005 ± 5 Thomson or at 3035 ± 5 Thomson, and consequently the issuing of a decision conditioned by this result.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to a method for detecting the interaction of at least one entity with a dielectric layer containing various electronic levels in the energy band gap of the dielectric layer, in which: a) the entity is deposited on the dielectric layer; b) the entity and the dielectric layer on which said entity is deposited are subjected to energising electromagnetic radiation, which does not take any observable luminosity from the actual entity, under the conditions implemented in step c); and c) the luminescence of the dielectric layer, in which the radiating and non-radiating electron transitions between the energy levels in the band gap have been influenced following the interaction thereof with the entity, is detected.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence

Abstract

The present invention relates to a method for preparing 1,2,3-trimethoxypropane from glycerol, in the presence of a methylating agent and a phase-transfer catalyst in a basic medium, to a composition including the 1,2,3-trimethoxypropane, and to the use thereof as a solvent for replacing a solvent used in the performance of a chemical reaction or as a reagent involved in said chemical reaction.

IPC Classes  ?

• C07C 41/16 - Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
• C07C 43/10 - Saturated ethers of polyhydroxy compounds
• A61K 8/33 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
• A61K 47/08 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen
• C09D 9/00 - Chemical paint or ink removers
• C10L 10/00 - Use of additives to fuels or fires for particular purposes
• C11D 3/43 - Solvents
• C11D 7/50 - Solvents

Abstract

The present invention relates to a method for preparing a polyol ether of general formula (I), including a reaction step involving a compound of general formula (II), a base, a methylating agent, and a phase-transfer catalyst in the absence of solvent. The invention also relates to a composition including a compound of formula (I) obtained by such a method, as well as to the use of said compound as a solvent for replacing a solvent used in the performance of a chemical reaction.

IPC Classes  ?

• C07C 41/01 - Preparation of ethers
• C07C 41/16 - Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
• C07C 43/10 - Saturated ethers of polyhydroxy compounds
• C07C 43/13 - Saturated ethers containing hydroxy or O-metal groups
• A61K 8/33 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
• A61K 47/08 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen
• C09D 9/00 - Chemical paint or ink removers
• C10L 10/00 - Use of additives to fuels or fires for particular purposes
• C11D 3/43 - Solvents
• C11D 7/50 - Solvents

Abstract

The invention relates to a method and kit for determining, in patients suffering from cancer, the aggressive nature of the cancer and/or the likelihood of the cancer developing metastases, in particular for breast or colon cancer.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer