Thermus aquaticusThermus aquaticus (Taq) DNA polymerase, a method for the detection of 5-methylcytosine nucleotides (5mC) in a DNA molecule of interest using said DNA polymerase, and a kit comprising said DNA polymerase. Further, the present invention concerns related DNA polymerases of Sequence Family A carrying the corresponding mutations.
Thermus aquaticusThermus aquaticus (Taq) DNA polymerase, a method for the detection of 5-methylcytosine nucleotides (5mC) in a DNA molecule of interest using said DNA polymerase, and a kit comprising said DNA polymerase. Further, the present invention concerns related DNA polymerases of Sequence Family A carrying the corresponding mutations.
A method, program and system for training a neural network to perform a machine learning task is provided. The method comprises receiving input data for the neural network. The method further comprises determining values for a plurality of hyperparameters of the neural network. The method further comprises building the neural network according to the hyper parameter values, wherein the neural network comprises a plurality of neurons. Each neuron includes a probability distribution for a plurality of logic operators, such that the neuron includes a corresponding probability for each of the logic operators. The method further comprises training the neural network according to the hyper parameter values and the input data by learning the probability distribution of each neuron. The method further comprises determining a logic operator of the plurality of logic operators for each neuron by selecting a value in the probability distribution.
The present invention relates to a process for producing a mixture that is insoluble in water of a homologous series of a number of various long-chain (≥C8) alkyl dicarboxylic acids, more particularly α,ω-n-alkyl dicarboxylic acids, by oxidative degradation of polyethylene (PE)-containing mixtures with oxygen, and to the mixtures or compositions obtainable therefrom and to their uses.
C07C 51/215 - Preparation of carboxylic acids or their salts, halides, or anhydrides by oxidation with molecular oxygen of saturated hydrocarbyl groups
C07C 51/44 - SeparationPurificationStabilisationUse of additives by change of the physical state, e.g. crystallisation by distillation
C07C 51/47 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
C07C 51/48 - SeparationPurificationStabilisationUse of additives by liquid-liquid treatment
C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material
5.
DOPING OF A SILICON SUBSTRATE BY LASER DOPING WITH A SUBSEQUENT HIGH-TEMPERATURE STEP
A method for doping a silicon substrate, in particular for a solar cell, includes coating a surface of the silicon substrate with a layer stack composed of at least two glass layers such that the layer stack at least covers a first region to be doped and a second region to be doped of the silicon substrate. the layer stack includes a first glass layer containing boron as p-type dopant and a second glass layer containing phosphorus as n-type dopant; and irradiating the first region covered with the layer stack with laser radiation such that dopant predominantly from the glass layer of the two glass layers that is closer to the surface of the silicon substrate than the other of the two glass layers is introduced into the silicon substrate close to the surface.
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
H01L 31/0288 - Inorganic materials including, apart from doping material or other impurities, only elements of Group IV of the Periodic System characterised by the doping material
The present description relates to a method for automatically determining an optimal individual dosing regimen of at least one drug. The method includes providing a mathematical model adapted to model a progression of said disease and an effect of the at least one drug on the progression of the disease, the model comprising individual model parameters associated with the patient. The method includes utilizing an empirical Bayesian estimation to automatically and numerically estimate the individual model parameters of the mathematical model. The method includes automatically calculating an optimal individual dosing regimen for the mathematical model by solving an optimal control problem based on a desired progression of the disease, the estimated individual model parameters, and an initial guess for the dosing regimen. The method includes adjusting the optimal individual dosing regimen to optionally account for at least one clinical constraint to yield the optimal individual dosing regimen.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
7.
METHOD FOR THE COMPUTER ASSISTED DETERMINATION OF PHYSICAL PROPERTIES OF A POROUS LAYER DISPOSED ON A SURFACE OF SUBSTRATE
A method and an apparatus (15) for computer-implemented determination of physical properties of a porous layer (1) present on a surface of a substrate. The physical properties include at least a layer thickness (d) of the layer, a porosity (p) of the layer and a roughness (r) of the layer at an interface (9) with the substrate supporting the layer. The method includes recording a reflectance curve (39) concerning light (25) irradiated onto the porous layer within a wavelength range in which the porous layer is largely transparent, setting a predetermined roughness start value, setting a porosity start value based on knowledge concerning a manufacturing process for forming the porous layer, setting a layer thickness start value based on an evaluation of periodic fluctuations of reflectance intensities within the recorded reflectance curve, and determining the physical properties of the porous layer by computer-implemented fitting of the recorded reflectance curve using a non-linear least squares method.
G01B 11/30 - Measuring arrangements characterised by the use of optical techniques for measuring roughness or irregularity of surfaces
G01B 11/06 - Measuring arrangements characterised by the use of optical techniques for measuring length, width, or thickness for measuring thickness
G01N 15/08 - Investigating permeability, pore volume, or surface area of porous materials
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
Described are to a biodegradable multilayer composite, in particular for food packaging, its use and a process for preparing said biodegradable multilayer composite.
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
B32B 27/20 - Layered products essentially comprising synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
B32B 27/22 - Layered products essentially comprising synthetic resin characterised by the use of special additives using plasticisers
The present invention relates to a compound which can be used in the treatment of infections caused by SARS coronaviruses, e.g. by blocking the active site of the proteases 3CLpro and PLpro. The compound can be used as inhibitor or label as such or can be used in screening methods for profiling other inhibitors. Moreover, the present invention relates to a method of producing the compound.
C07D 211/28 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
C07C 237/22 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
C07D 311/74 - Benzo [b] pyrans, hydrogenated in the carbocyclic ring
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
10.
TRAINING A NEURAL NETWORK TO PERFORM A MACHINE LEARNING TASK
A method, program and system for training a neural network to perform a machine learning task is provided. The method comprises receiving input data for the neural network. The method further comprises determining values for a plurality of hyperparameters of the neural network. The method further comprises building the neural network according to the hyper parameter values, wherein the neural network comprises a plurality of neurons. Each neuron includes a probability distribution for a plurality of logic operators, such that the neuron includes a corresponding probability for each of the logic operators. The method further comprises training the neural network according to the hyper parameter values and the input data by learning the probability distribution of each neuron. The method further comprises determining a logic operator of the plurality of logic operators for each neuron by selecting a value in the probability distribution.
The present invention relates to a process for producing a mixture that is insoluble in water of a homologous series of a number of various long-chain (≥ C8) alkyl dicarboxylic acids, more particularly α,ω-n-alkyl dicarboxylic acids, by oxidative degradation of polyethylene (PE)-containing mixtures with oxygen, and to the mixtures or compositions obtainable therefrom and to their uses.
C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material
12.
METHOD, SYSTEM AND COMPUTER PROGRAM FOR COMPUTATION OF OPTIMAL INDIVIDUAL DOSING REGIMEN, PARTICULARLY SUBJECT TO CLINICAL CONSTRAINTS
The present invention relates to a method for automatically determining an optimal individual dosing regimen of at least one drug for a patient suffering from a known disease, the optimal individual dosing regimen being optionally subject to at least one clinical constraint, wherein the method comprises the steps of: providing a mathematical model adapted to model a progression of said disease and an effect of the at least one drug on the progression of the disease, the model comprising individual model parameters associated with the patient; utilizing an empirical Bayesian estimation to automatically and numerically estimate the individual model parameters of the mathematical model utilizing patient data associated with the patient; automatically calculating an optimal individual dosing regimen for the mathematical model by solving an optimal control problem based on a desired progression of the disease, the estimated individual model parameters, and an initial guess for the dosing regimen; and adjusting the optimal individual dosing regimen to optionally account for at least one clinical constraint to yield the optimal individual dosing regimen subject to said at least one clinical constraint.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
13.
DOPING OF A SILICON SUBSTRATE BY LASER DOPING WITH A SUBSEQUENT HIGH-TEMPERATURE STEP
A method of doping a silicon substrate (1), especially for a solar cell (25), comprises: coating a surface of the silicon substrate with a layer stack (7) composed of at least two glass layers (9, 11), such that the layer stack covers at least a first region (3) to be doped and a second region (5) to be doped of the silicon substrate, wherein the layer stack comprises a first glass layer (9) containing boron as p-type dopant and a second glass layer (11) containing phosphorus as n-type dopant; irradiating the first region covered by the layer stack with laser radiation (17) in such a way that dopant is introduced into the silicon substrate close to the surface predominantly from the one of the two glass layers closer to the surface of the silicon substrate than the other of the two glass layers, and the layer stack is ablated in order to obtain a doped first region from which the layer stack has been ablated, wherein the second region covered by the layer stack is not irradiated with the laser radiation and hence the layer stack is not ablated there; and, subsequently, heating the silicon substrate in a furnace (19) to a temperature of at least 700°C such that dopant is introduced into the silicon substrate close to the surface predominantly from one of the two glass layers, in order to obtain a doped second region, the doping of which differs in polarity and/or doping intensity from a doping of the doped first region.
H01L 31/068 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN homojunction type, e.g. bulk silicon PN homojunction solar cells or thin film polycrystalline silicon PN homojunction solar cells
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
14.
OPTO-ELECTRONIC DEVICE AND METHOD FOR PROVIDING VISUAL ORIENTATION
An opto-electronic device (100) is disclosed. The opto-electronic device (100) comprises at least one sensor (106) configured to obtain head orientation data including information on an orientation of a user's head, a processing unit (112) configured to process the head orientation data so as to obtain self motion data including information on the user's self motion and to provide at least one visual cue (114) based on the obtained self motion data, and a display device (120) configured to display the at least one visual cue (114) at a dis-play (102) at least in a periphery of a visual field of the user. Further, a method for providing visual orientation is disclosed.
The present invention relates to a multifunctional, surface-active comb polymer for compatibilization of at least two phases, and to a process for preparing the multifunctional, surface-active comb polymer according to the invention.
Described are a method and a device (15) for the computer-assisted determination of physical properties of a porous layer (1) disposed on a surface of a substrate (3). The physical properties comprise at least a layer thickness (d) of the layer, a porosity (p) of the layer and a roughness (r) of the layer at a boundary surface (9) to the substrate carrying the layer. The method comprises: - acquiring a reflection profile (39) of the light (25) incident on the porous layer within a wavelength range in which the porous layer is largely transparent, - setting a predefined roughness start value, - setting a porosity start value based on knowledge of a production process for forming the porous layer, - setting a layer thickness start value based on an evaluation of periodic fluctuations in reflection intensities within the reflection profile acquired, - determining the physical properties of the porous layer by computer-assisted fitting of the acquired reflection profile using a nonlinear least squares method, for example a Levenberg-Marquardt algorithm or a trust region method, proceeding from the roughness start value, the porosity start value and the layer thickness start value.
In a first aspect, the present invention relates to a polymer blend, comprising: (i) 1 to 99.9 weight-% of a first polyethylene-like polymer having a repetition unit (I) within its structure [-X12aa-X22bb-] (I) wherein X122-O-group; X222-O-group; a, b are each an integer independently selected from the range from 2 to 200 wherein the first polyethylene-like polymer has in the range of from 89 to 99.5 mol% of methylene groups; and (ii) 0.1 to 99 weight-% of a second polymer; wherein the sum of the weight-% of (i) and (ii) amounts to 100 weight-%. A second aspect of the invention relates to the use of a polymer blend according to the first aspect as a material, preferably for a consumer article, preferably selected from the group consisting of a cup, a plate, cutlery, a sanitary article, a packaging article, and a film.
C08G 65/34 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
C08G 79/04 - Phosphorus linked to oxygen or to oxygen and carbon
The present invention relates to a compound which can be used in the treatment of infections caused by SARS coronaviruses, e.g. by blocking the active site of the proteases 3CLproand PLpro. The compound can be used as inhibitor or label as such or can be used in screening methods for profiling other inhibitors. Moreover, the present invention relates to a method of producing the compound.
C07C 233/15 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
C07C 233/19 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
C07C 233/38 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
C07C 233/88 - Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
C07C 323/29 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
C07D 211/28 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
C07D 311/74 - Benzo [b] pyrans, hydrogenated in the carbocyclic ring
C07C 237/22 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof
C08J 9/30 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by mixing gases into liquid compositions or plastisols, e.g. frothing with air
20.
POLYETHYLENE-TYPE MATERIALS, THE SOLVOLYSIS THEREOF AND PRODUCTION OF FINISHED PARTS THEREFROM
22) and at least one functional group selected from group O-C(=O) and group O-C(=O)-O, the polyethylene-type polymer having a number-average molecular weight (Mn) in the range of 20,000 to 10,000,000 g/mol. In a second aspect, the invention relates to a method for producing specific monomers of general formula (II) and/or specific oligomers of general formula (III). In a third aspect, the invention relates to a composition comprising a monomer of general formula (II) and/or an oligomer of general formula (III), the composition being obtained or obtainable by means of the method of the second aspect. A fourth aspect of the invention relates to the use of the composition according to the third aspect to produce polymers. A fifth aspect of the invention relates to a method for producing a finished part, comprising: - provision of a material having a polyethylene-type polymer; and - primary forming of the material. A sixth aspect of the invention relates to a method for producing a finished part from a material, the material having a polyethylene-type polymer, wherein the finished part is produced by means of an additive manufacturing method.
C08J 11/24 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material by treatment with organic oxygen-containing compounds containing hydroxyl groups
C07B 37/06 - Decomposition, e.g. elimination of carbon dioxide
C07C 29/09 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
C07C 29/128 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by alcoholysis
There are provided a method for producing a photovoltaic element with stabilised efficiency, and a device which may be used to carry out the method, for example in the form of a specially adapted continuous furnace. A silicon substrate to be provided with an emitter layer and electrical contacts is thereby subjected to a stabilisation treatment step. In that step, hydrogen, for example from a hydrogenated silicon nitride layer, is introduced into the silicon substrate, for example within a zone (2) of maximum temperature. The silicon substrate may then purposively be cooled rapidly in a zone (3) in order to avoid hydrogen effusion. The silicon substrate may then purposively be maintained, for example in a zone (4), within a temperature range of from 230° C. to 450° C. for a period of, for example, at least 10 seconds. The previously introduced hydrogen may thereby assume an advantageous bond state. At the same time or subsequently, a regeneration may be carried out by generating excess minority charge carriers in the substrate at a temperature of at least 90° C., preferably at least 230° C. Overall, with the proposed method, a regeneration process in the production of a photovoltaic element may be accelerated significantly so that it may be carried out, for example, in a suitably modified continuous furnace.
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
H01L 31/068 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN homojunction type, e.g. bulk silicon PN homojunction solar cells or thin film polycrystalline silicon PN homojunction solar cells
H01L 21/677 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for conveying, e.g. between different work stations
F27B 9/40 - Arrangements of controlling or monitoring devices
H01L 21/67 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components
F27B 9/06 - Furnaces through which the charge is moved mechanically, e.g. of tunnel type Similar furnaces in which the charge moves by gravity heated without contact between combustion gases and chargeFurnaces through which the charge is moved mechanically, e.g. of tunnel type Similar furnaces in which the charge moves by gravity electrically heated
22.
CALCIUM COACERVATES FOR REMINERALIZATION AND FOR DEMINERALIZATION INHIBITION
The invention relates to calcium coacervate for use in a method for caries prevention and/or caries treatment, comprising a step during which dental enamel is infiltrated with calcium coacervate; and to kits that comprise: a) a phosphate ion-containing solution; and b1) a calcium coacervate-containing emulsion and/or b2) a second solution comprising polyanions and/or their salts, and a calcium ion-containing third solution.
An apparatus (1) for measuring a radiation intensity is presented, in particular for measuring radiation in a continuous furnace as used in the regeneration of solar cells during the production thereof. The apparatus (1) comprises a radiation sensor (3), a measuring device (5) and a holding device (7). The radiation sensor (3) has a radiation-sensitive detection area (9) and, when radiation impinges on the detection area (9), generates a radiation sensor signal, which is dependent on the radiation intensity. The measuring device (5) has measurement electronics (11) for controlling a function of the radiation sensor (3) and/or for evaluating the radiation sensor signal. The measuring device (5) further has a housing (27) which surrounds the measurement electronics (11) in a thermally insulating fashion in order to protect them from temperature-related damage in environments with temperatures of at least up to 100°C and radiation intensities of at least up to 1 kW/m2. The holding device (7) holds the radiation sensor (3).
The present invention relates to a compound which can be used in the treatment of infections with pathogenic bacteria, in particular pathogens mediating pathogenicity by quinolone dependent production of virulence factors, such as e.g. Pseudomonas aeruginosa and species of the genus Burkholderia, and which can be used for treating bacterial or chronic infections or can be used in combination with other anti-bacterial agents, such as antibiotics, to increase sensitivity of the bacteria for treatment of e.g. multiresistant strains in e.g. mammals.
A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
The present invention relates to a compound, which can be used as an anti-bacterial and/or an anti-fungal agent as well as a zinc sensor. Moreover, the present invention relates to a pharmaceutical composition comprising said compound and methods for treating bacterial or fungal infections in mammals.
A01N 43/18 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with sulfur as the ring hetero atom
C07D 215/42 - Nitrogen atoms attached in position 4
C07D 345/00 - Heterocyclic compounds containing rings having selenium or tellurium atoms as the only ring hetero atoms
C07D 211/22 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms by oxygen atoms
A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
A01N 43/42 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
A01N 55/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
C07D 311/24 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Neisseria N. gonorrhoeaeN. meningitidisHaemophilus Moraxellacatarrhaliscatarrhalis), and which can be used for disinfecting a substrate from said bacteria. Moreover, the present invention relates to a corresponding pharmaceutical composition comprising said compound.
C07D 215/58 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
The invention relates to a multifunctional block copolymer, which comprises a hydrophilic non-acidic polymer block (A) and also a hydrophilic acidic polymer block (B) and/or a hydrophobic polymer block (C), wherein the hydrophobic polymer block (C) is provided with a steroid or a derivative thereof and the multifunctional block copolymer has at least the structure (A)-(C), (A)-(B)-(C), (A)-(C)-(B) or a combination of the structures (A)-(B) and (A)-(C). The invention further relates to a polymeric nanoparticle that is formed by self-assembly and that is based on the multifunctional block copolymer according to the invention, to a pharmaceutical composition comprising the polymeric nanoparticle, and to the use of said composition to absorb cholesterol molecules and possibly calcium ions from atherosclerotic plaques.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61P 9/00 - Drugs for disorders of the cardiovascular system
The present invention relates to a compound, which can be used as an anti-bacterial and/or an anti-fungal agent as well as a zinc sensor. Moreover, the present invention relates to a pharmaceutical composition comprising said compound and methods for treating bacterial or fungal infections in mammals.
C07D 345/00 - Heterocyclic compounds containing rings having selenium or tellurium atoms as the only ring hetero atoms
C07D 211/22 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms by oxygen atoms
The present invention relates to modified nucleosides which are linked to cargo molecules and which can be incorporated by DNA or RNA polymerases in strand synthesis. The present invention also relates to use of such modified nucleosides as substrates for DNA or RNA polymerases. The present invention also relates to the use of such modified nucleosides in diagnosis and prognosis of diseases or disorders associated with a target sequence. The present invention also relates to methods for producing such modified nucleosides, kits comprising such nucleosides, and in vitro methods for diagnosing or predicting diseases or disorders associated with a target sequence. The present invention also relates to modified nucleosides for use in diagnosing, predicting or treating diseases or disorders associated with a target sequence.
heating the such prepared silicon substrate (1) to temperatures above 300° C., preferably above 900° C., in a furnace in an atmosphere containing significant quantities of the first dopant type. Additionally, at least a third doped subzone (15) doped with the second dopant type may be produced by the method additionally comprising, prior to the heating, a covering of the doping layer (7), above the third doped subzone (15) to be produced, with a further layer (17) acting as a diffusion barrier for the first dopant type.
The method uses the observation that a borosilicate glass layer seems to promote an in-diffusion of phosphorus from a gas atmosphere and may substantially facilitate a manufacturing for example of solar cells, in particular back contact solar cells.
H01L 31/068 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN homojunction type, e.g. bulk silicon PN homojunction solar cells or thin film polycrystalline silicon PN homojunction solar cells
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
H01L 21/225 - Diffusion of impurity materials, e.g. doping materials, electrode materials, into, or out of, a semiconductor body, or between semiconductor regionsRedistribution of impurity materials, e.g. without introduction or removal of further dopant using diffusion into, or out of, a solid from or into a solid phase, e.g. a doped oxide layer
H01L 21/223 - Diffusion of impurity materials, e.g. doping materials, electrode materials, into, or out of, a semiconductor body, or between semiconductor regionsRedistribution of impurity materials, e.g. without introduction or removal of further dopant using diffusion into, or out of, a solid from or into a gaseous phase
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
H01L 31/0376 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their crystalline structure or particular orientation of the crystalline planes including amorphous semiconductors
H01L 21/38 - Diffusion of impurity materials, e.g. doping materials, electrode materials, into, or out of, a semiconductor body, or between semiconductor regions
H01L 21/04 - Manufacture or treatment of semiconductor devices or of parts thereof the devices having potential barriers, e.g. a PN junction, depletion layer or carrier concentration layer
H01L 21/22 - Diffusion of impurity materials, e.g. doping materials, electrode materials, into, or out of, a semiconductor body, or between semiconductor regionsRedistribution of impurity materials, e.g. without introduction or removal of further dopant
H01L 21/18 - Manufacture or treatment of semiconductor devices or of parts thereof the devices having potential barriers, e.g. a PN junction, depletion layer or carrier concentration layer the devices having semiconductor bodies comprising elements of Group IV of the Periodic Table or AIIIBV compounds with or without impurities, e.g. doping materials
H01L 21/24 - Alloying of impurity materials, e.g. doping materials, electrode materials, with a semiconductor body
31.
Mutated DNA polymerases with high selectivity and activity
The present invention provides DNA polymerases and their use in various applications. The present invention also relates to uses and methods utilizing the DNA polymerase of the present invention for discriminating between matched and mismatched primers or detecting SNP or methylated cytosine. The present invention also relates to kits comprising such DNA polymerases.
The invention relates to a material for bone implants, comprising: a surface consisting of oxide ceramic materials, titanium or polyether ether ketone (PEEK) or other polymer or composite materials; a matrix which consists of collagen or gelatin and is covalently bonded to said surface; and calcium phosphate which is embedded into said matrix. The invention also relates to a method for producing the claimed material, to bone implants comprising the claimed material, and to the use of same as a bone implant material.
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
33.
Direct, programmable detection of epigenetic DNA cytosine modifications using TAL effectors
Methods for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of the cytosine residue of interest or (ii) an unmodified cytosine residue of interest, the methods making use of the capability of transcription-activator-like effector (TALE) proteins to preferentially bind with strong affinity to nucleic acid sequences containing non-modified cytosine residues or 5-methyl modified cytosine residues, and to bind, if at all, with only strongly reduced affinity to nucleic acid sequences containing 5-hydroxymethyl modified cytosine residues. The present invention further relates to respective uses of TALE proteins for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of the cytosine residue of interest or (ii) the unmodified cytosine residue of interest.
According to an example, in a method for producing a photovoltaic element with stabilised efficiency, a silicon substrate may be provided with an emitter layer and electrical contacts, which may be subjected to a stabilisation treatment step. Hydrogen from a hydrogenated silicon nitride layer may be introduced into the silicon substrate, for example, within a zone of maximum temperature. The silicon substrate may then be cooled rapidly in a zone in order to avoid hydrogen effusion. The silicon substrate may then be maintained, for example in a zone within a temperature range of from 230° C. to 450° C. for a period of, for example, at least 10 seconds. The previously introduced hydrogen may thereby assume an advantageous bond state. At the same time or subsequently, a regeneration may be carried out by generating excess minority charge carriers in the substrate at a temperature of at least 90° C., preferably at least 230° C.
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
H01L 31/068 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN homojunction type, e.g. bulk silicon PN homojunction solar cells or thin film polycrystalline silicon PN homojunction solar cells
H01L 21/677 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for conveying, e.g. between different work stations
F27B 9/40 - Arrangements of controlling or monitoring devices
H01L 21/67 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components
F27B 9/06 - Furnaces through which the charge is moved mechanically, e.g. of tunnel type Similar furnaces in which the charge moves by gravity heated without contact between combustion gases and chargeFurnaces through which the charge is moved mechanically, e.g. of tunnel type Similar furnaces in which the charge moves by gravity electrically heated
35.
PRODUCTION AND ISOLATION OF A NATIVE HUMAN DERMAL EXTRACELLULAR MATRIX
The present invention relates to functionalized extracellular matrices, composites of functionalized extracellular matrices and carriers, to processes for their preparation and uses thereof.
A method for producing at least two partial regions (3, 5) doped to different extents predominantly with a first dopant type in a silicon substrate (1), more particularly for a solar cell, comprising: covering at least one first partial region (3) of the silicon substrate, in which a higher doping with the first dopant type is intended to be produced, with a doping layer (7) composed of borosilicate glass, wherein at least one second partial region (5) of the silicon substrate, in which a weaker doping with the first dopant type is intended to be produced, is not covered with the doping layer, and wherein boron as dopant of a second dopant type, which is of opposite polarity to the first dopant type, is incorporated into the layer; and heating the silicon substrate prepared in this way in a furnace in an atmosphere of the first dopant type. The method makes use of the observation that a borosilicate glass layer appears to promote indiffusion of phosphorus from a gas atmosphere.
H01L 31/068 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN homojunction type, e.g. bulk silicon PN homojunction solar cells or thin film polycrystalline silicon PN homojunction solar cells
H01L 21/225 - Diffusion of impurity materials, e.g. doping materials, electrode materials, into, or out of, a semiconductor body, or between semiconductor regionsRedistribution of impurity materials, e.g. without introduction or removal of further dopant using diffusion into, or out of, a solid from or into a solid phase, e.g. a doped oxide layer
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
Thermus aquaticus (Taq) polymerase, comprising the mutations S515R, I638F, and M747K with regard to the wild-type amino acid sequence. The present invention further relates to nucleic acids coding for the DNA polymerases of the present invention, vectors containing said nucleic acids, host cells containing said vectors or nucleic acids, methods for the generation of DNA molecules using said DNA polymerases, kits containing said DNA polymerases, and uses thereof.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
C12P 21/04 - Cyclic or bridged peptides or polypeptides, e.g. bacitracin
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
A method for producing a solar cell is described, in which a plurality of doped regions are to be etched-back selectively or over their entire surface. Once a semiconductor substrate (1) has been provided, various doped regions (3, 5) are formed in partial regions of a surface of the semiconductor substrate, the various doped regions (3, 5) differing as regards their doping concentration and/or their doping polarity. The various doped regions (3, 5) are then purposively etched-back in order to achieve desired doping profiles, and finally electrical contacts (21) are formed at least at some of the doped regions (3, 5). The etching-back of the various doped regions takes place in a common etching operation in an etching medium. In order that such common etching-back of various doped regions (3, 5) is possible, it is proposed purposively to adjust both properties of the initially unetched doped regions (3, 5) and parameters that influence the etching operation with regard to properties of the desired doping profiles within the etched doped regions.
H01L 31/068 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN homojunction type, e.g. bulk silicon PN homojunction solar cells or thin film polycrystalline silicon PN homojunction solar cells
The invention relates to a non-canonical amino acid of the formula I, namely A - L - X, A is a lysine or a tyrosine, L is a linker or absent, and X is an aminoxyl radical or photocaged aminoxyl radical, and if A is lysine, L is bound to the N-epsilon atom of the lysine or, if L is absent, X is bound to the N-epsilon atom of the lysine; and if A is tyrosine, L is bound to the phenolic hydroxyl of the tyrosine or, if L is absent, X is bound to the phenolic hydroxyl of the tyrosine. Moreover, the invention also relates to a method for introducing a spin label into a protein and to a modified pyrrolysyl-tRNA- synthetase.
The present invention provides DNA polymerases and their use in various applications. The present invention also relates to uses and methods utilizing the DNA polymerase of the present invention for discriminating between matched and mismatched primers or detecting SNP or methylated cytosine. The present invention also relates to kits comprising such DNA polymerases.
The invention relates to a method for generating doped and/or metallized regions on a surface (3) of a semiconductor substrate (1) for a solar cell. A pattern is formed on the surface (3) from different types of regions (5, 7), such as lower-set sub-regions (5) and higher-set sub-regions (7). Into the lower-set sub-regions (5), a flowable substance (11) is introduced, such as in the form of a screen printing paste or an inkjet ink, which contains doping materials and/or metal particles and additionally contains a deflocculant to increase flowability. As a result of the flowability thereof, the substance (11), first introduced in a droplet shape, for example, flows laterally and preferably uniformly fills the lower-set regions (5). The deflocculant can then be evaporated or converted out of the flowable substance (11), and the substance thus solidified. Metal particles contained in the substance (11) can then be fired in order to form electrical metal contacts, for example, or doping materials contained in the substance (11) can be diffused to form emitter regions for the solar cell, for example. By means of the method according to the invention, a risk of short-circuit paths in solar cells can be reduced and production tolerances can be greater than in conventional production methods for solar cells.
H01L 31/068 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN homojunction type, e.g. bulk silicon PN homojunction solar cells or thin film polycrystalline silicon PN homojunction solar cells
The invention relates to a non-canonical amino acid (ncAA) comprising a lysine and an aromatic residue and to a peptide comprising such a ncAA. The invention further relates to the use of a ncAA comprising a lysine and an aromatic residue for enhancing the affinity of a nucleic acid binding peptide and to a method for producing a nucleic acid binding compound.
C07D 241/44 - Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
The invention relates to a method and a prokaryotic cell for identifying a compound, which interferes with ribosome biogenesis, assembly and/or degradation. The cell expresses a first fusion protein comprising a first ribosomal protein, an amino acid linker and a first fluorescent protein, and a second fusion protein comprising a second ribosomal protein, an amino acid linker and a second fluorescent protein. The invention further relates to a gene construct comprising a first element encoding a first ribosomal protein fused to a first fluorescent protein by an amino acid linker, and a second element encoding a second ribosomal protein fused to a second fluorescent protein by an amino acid linker.
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12Q 1/18 - Testing for antimicrobial activity of a material
44.
DIRECT, PROGRAMMABLE DETECTION OF EPIGENETIC DNA CYTOSINE MODIFICATIONS USING TAL EFFECTORS
The present invention relates to methods for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of said cytosine residue of interest o,r (ii) said unmodified cytosine residue of interest, said methods making use of the capability of transcription-activator-like effector (TALE) proteins to preferentially bind with strong affinity to nucleic acid sequences containing non-modified cytosine residues or 5-methyl modified cytosine residues, and to bind, if at all, with only strongly reduced affinity to nucleic acid sequences containing 5-hydroxymethyl modified cytosine residues. The present invention further relates to respective uses of TALE proteins for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of said cytosine residue of interest or (ii) said unmodified cytosine residue of interest.
A method for producing a photovoltaic element with stabilized efficiency and a device that can be used for carrying out this method, for example in the form of a specially adapted continuous furnace, are presented. A silicon substrate that is to be provided with an emitter layer and electrical contacts is subjected to a stabilizing treatment step. In this step, hydrogen, for example coming from a hydrogenated silicon nitride layer, is introduced into the silicon substrate, for example within a zone (2) of maximum temperature. Subsequently, the silicon substrate can be rapidly cooled in a specific manner in a zone (3) in order to avoid hydrogen effusion. After that, the silicon substrate can be kept within a temperature range from 230°C to 450°C for a period of for example at least 10 seconds in a specific manner, for example in a zone (4). This allows the previously introduced hydrogen to assume a favourable bonding state. At the same time or subsequently, a regeneration may be carried out, in that excess minority charge carriers are produced in the substrate at a temperature of at least 90°C, preferably at least 230°C. Altogether, with the method proposed, a regeneration process in the production of a photovoltaic element can be speeded up significantly, and so it can for example be carried out in a suitably modified continuous furnace.
H01L 31/068 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN homojunction type, e.g. bulk silicon PN homojunction solar cells or thin film polycrystalline silicon PN homojunction solar cells
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
46.
METHOD FOR THE DETERMINATION OF BIOLOGICAL AGE IN HUMAN BEINGS
The present invention relates to methods for the determination of the biological age of a human being. This method is based on the findings of a multinational study screening for biomarkers of aging in humans.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
47.
BUSBARLESS REAR‑CONTACT SOLAR CELL, METHOD OF MANUFACTURE THEREFOR AND SOLAR MODULE HAVING SUCH SOLAR CELLS
A busbarless rear‑contact solar cell and possible electrical interconnection thereof are presented. The substrate reverse (5) of a semiconductor substrate (3) has a plurality of linear emitter regions (15) and base regions (17) with which electrical contact is made by likewise linear emitter metal contacts (7) and base metal contacts (9), with the emitter metal contacts (7) being connected to one another, and the base metal contacts (9) being connected to one another, in electrically conductive fashion not by busbars that run parallel thereto and are in electrical contact with the substrate reverse (5). Each of the emitter metal contacts (7) and each of the base metal contacts (9) have, along an emitter region (15) or base region (17) that is in contact therewith, a plurality of interruptions (29, 31) that are substantially shorter than adjoining uninterrupted regions of emitter and base metal contacts (7, 9). First and second metal wires (19, 21) that are used for the interconnection of the solar cell can run through these interruptions (29, 31) so as to cross the emitter and base regions (15, 17), without producing shorts.
H01L 31/05 - Electrical interconnection means between PV cells inside the PV module, e.g. series connection of PV cells
H01L 31/068 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN homojunction type, e.g. bulk silicon PN homojunction solar cells or thin film polycrystalline silicon PN homojunction solar cells
48.
DEVICE FOR NON-PERMANENT ELECTRICAL CONTACTING OF SOLAR CELLS IN ORDER TO MEASURE ELECTRICAL PROPERTIES
The invention relates to a contacting device (1) and a measuring device (45), which can be used for non-permanent electrical contacting of solar cells (3) when determining electrical properties such as an I-V characteristic of the solar cell (3) as part of a solar cell classification. The contacting device (1) has a rigid optically transparent carrier plate (5), made of glass for example. A plurality of electrical leads (7) are arranged on the carrier plate (5) along a surface of the carrier plate (5) and protruding therefrom. For example, the electrical leads (7) can run along trench-like recesses (23) formed in the carrier plate (5). The electrical leads (7) can make contact with contact fingers (21) of the solar cell (3) uniformly and preferably under conditions such as those also prevailing in the encapsulated state of the solar cell (3) in a solar module; in particular, solar cells (3) without bus bars can also be contacted.
The present invention relates to DNA polymerases displaying increased substrate scope such as improved reverse transcriptase and DNA polymerase activities, as well as improved activities for incorporating and extending modified nucleotides. In particular, the present invention relates to DNA polymerases derived from wild-type Thermus aquaticus (Taq) polymerase, comprising the mutations S515R, I638F, and M747K with regard to the wild-type amino acid sequence. The present invention further relates to nucleic acids coding for the DNA polymerases of the present invention, vectors containing said nucleic acids, host cells containing said vectors or nucleic acids, methods for the generation of DNA molecules using said DNA polymerases, kits containing said DNA polymerases, and uses thereof.
The present invention relates to the means and methods for the detection of the methylation status of cytosine residues and in particular to the use of at least one primer which is at least 5 nucleotides in length, and which hybridizes to a target sequence that comprises at least one defined 5'-CpG-3' which target sequence is comprised in a genomic DNA of a vertebrate, and which has its 3'end opposite to the C of said 5'-CpG-3', and which comprises at said 3'end a mismatched nucleotide in relation to said C of said 5'-CpG- 3', for determining the methylation status of a vertebrate genomic nucleic acid at said C. Said mismatched base at the 3'-end of the primer does not sufficiently pair with the cytosine of interest, in case said cytosine is not methylated or hydroxymethylated, thus impairing for example a DNA polymerase reaction with said primer using said DNA molecule as template. However, said mismatched base at the 3'-end of the primer pairs sufficiently with the cytosine of interest, in case said cytosine is methylated or hydroxymethylated, thus allowing a DNA polymerase reaction with said primer using said DNA molecule as template. The present invention further relates to polymerase proteins that can be used in the embodiments of the present invention. The present invention also relates to a kit comprising at least one primer of the invention and optionally means to conduct the amplification.
The present invention relates to a method for directly detecting methylation or hydroxymethylation of a cytosine residue of interest in a DNA molecule. Said method comprises steps of providing a primer having its 3'-end opposite of the cytosine residue of interest and having at said 3'-end a mismatched base, performing a specific DNA polymerase reaction, such as primer extension, rolling circle amplification (RCA) or polymerase chain reaction (PCR), with said primer using said DNA molecule as template, and detecting said methylation or hydroxymethylation via an increased efficiency of said specific DNA polymerase reaction as compared to the same reaction performed with an unmodified DNA molecule as template.
The invention relates to a method for producing a solar cell, to a device for producing a metal structure on a solar cell substrate and to a correspondingly produced solar cell. In the method, a thin metal layer (29) with a thickness of less than 5 µm, preferably less than 0.5 µm, is deposited on a solar cell substrate (27). Then, preferably with the aid of an interference pattern (25) generated by superimposing two laser beams, illumination subsurfaces (33) of the metal layer (29) are illuminated sufficiently intensively such that no metal evaporates, but the metal layer (29) briefly melts locally over its entire thickness, whereas adjoining web subsurfaces (35) are illuminated less or not at all and thus do not melt. In the locally melted metal layer, de-wetting effects can occur due to surface tensions, meaning that the metal shifts and exposed surface regions (37) are formed on the solar cell substrate (27). The displaced metal assists in increasing the thickness of webs (39). These webs (39) can be used both as metal contacts or as seed layers for such metal contacts and also as an etching mask or for fine reflection-reducing surface texturing during the production of the solar cell.
The present invention relates to fucose- and mannose-derived glycomimetics and their general use in prophylaxis or treatment of Pseudomonas aeruginosa infections including respiratory tract infections, urinary tract infections, nosocomial infections and chronic wound infections in a patient encompassing a patient suffering already from cystic fibrosis. Said glycomimetics are inhibitors of Pseudomonas aeruginosa lectin LecB.
C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical
C07D 309/02 - Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
PRINTABLE MEDIUM THAT CONTAINS METAL PARTICLES AND EFFECTS ETCHING, MORE PARTICULARLY FOR MAKING CONTACT WITH SILICON DURING THE PRODUCTION OF A SOLAR CELL
A printable medium is proposed, such as can be used, for example, during the production of metal contacts (11) for silicon solar cells which are covered with a passivation layer (9) on a surface (7) of a silicon substrate (1). A corresponding production method and a correspondingly produced solar cell are also disclosed. The printable medium contains at least one medium that etches the passivation layer (9) and metal particles such as nickel particles (15), for example. By locally applying the printable medium to the passivation layer and subsequent heating, the passivation layer (9) can be opened locally with the aid of the etching medium. As a result, the nickel particles (15) can form a mechanical and electrical contact with the substrate surface (7), preferably with the formation of a nickel silicide layer (19). The printable medium and the production method made possible therewith are cost-effective owing to the use of nickel particles, for example, and allow both good electrical contact and avoidance of undesirable high-temperature steps.
RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT BONN (Germany)
UNIVERSITÄT KONSTANZ (Germany)
Inventor
Mayer, Günter
Lünse, Christina, Elsbeth
Wittmann, Valentin
Schmidt, Magnus, S.
Abstract
The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.
C07C 213/02 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
C07C 215/44 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
C07F 9/144 - Esters of phosphorous acids with cycloaliphatic alcohols
A61K 31/133 - Amines, e.g. amantadine having hydroxy groups, e.g. sphingosine
A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
56.
DEVICE FOR MEASURING A CHARGE-CARRIER SERVICE LIFE IN A SEMICONDUCTOR SUBSTRATE
Proposed is a device for measuring a charge-carrier service life in a semiconductor substrate. The measuring device can be adapted for a PLI (photoluminescence imaging) measurement method. The device (1) has a camera system (9). A chopper (17) is used to temporarily interrupt and open up a beam path (7) between a semiconductor substrate (3) and the camera system (9). In addition, an additional objective (25) is provided between the substrate position and the camera system (9), which additional objective (25) is configured to generate an intermediate image of the semiconductor substrate (3) in an intermediate image plane Z. The chopper (17) is arranged in the region of the intermediate image plane Z of the additional objective (25). Since the beam path (7) has a minimum cross section here, slits (21) having a small width can be formed in a chopper disc (19), such that a great number of narrow slits (21) can be formed in the chopper disc (19). Alternatively, a chopper can be implemented using an electronically controllable photomultiplier. Owing to the thus possible increased measurement frequency, the temporal resolution of the measurement device can be increased in comparison with conventional devices, and dynamic service-life measurements in the microsecond range can be made possible.
The invention relates to a method for producing a solar cell (100) and to a solar cell which can be produced accordingly. On a solar cell substrate (1), first a ridged texture (7), which may for example comprise pyramids (7) produced by alkaline etching, is formed both on a front face (3) and on a rear face (5) of the solar cell substrate (1). Then an etching barrier layer is applied to the front face of the solar cell substrate (1). Next the texture (7) on the rear face (5) of the solar cell substrate (1) is smoothed by etching in an isotropically acting etching solution which for example contains acid, wherein the front face (3) is protected by the etching barrier layer. Thus, ridged structures on the rear face (5) can be avoided and in this way reflection can be increased and surface passivation can be improved, both of which can lead to an increased potential efficiency. At the same time an emitter layer (13) formed over the entire surface of the solar cell substrate (1) on the rear face (5) can be removed during etching, so that electrical isolation of the front face contacts (23) and the rear face contacts (25) may be superfluous.
There is described the use of a peptide (1) for the preparation of an agent for detecting an antigen (4) which (a) includes an amino acid sequence of a paratope (7) of an antibody (6) which is directed against the antigen (4), b) binds specifically to an epitope (5) of the antigen (4) and c) includes an 11C carbon atom. There is furthermore provided a radiopharmaceutical for locating a tumour, which radiopharmaceutical comprises a peptide (1) which includes an 11C carbon atom. The peptide (1) includes an amino acid sequence of a paratope (7) of an antibody (6) which is directed against the tumour (18).
There is described the use of a peptide (1) for the preparation of an agent for detecting an antibody (4), where the peptide (1) binds to a paratope (5) of the antibody (4) and includes an 11C carbon atom. Also provided is a radiopharmaceutical for locating a tumour (18) comprising a peptide (1) which includes an 11C carbon atom, where the peptide (1) binds to a paratope (5) of an antibody (4) which is directed against the tumour (18).
THURGAUISCHE STIFTUNG FÜR WISSENSCHAFT UND FORSCHUNG (Germany)
Inventor
Groettrup, Marcus
Oehlschlaeger, Peter
Abstract
The present invention concerns an (adjuvant) treatment or prevention option for the treatment and prevention of prostate cancer. In particular, it pertains to the provision of recombinant, optimized PAP genes which are useful as DNA vaccines for the above treatment or prevention.
The invention relates to a method for texturing a surface of a semiconductor substrate. The surface is etched with an etching solution that etches the semiconductor substrate material, wherein a wetting agent that contains water-soluble polymers, in particular in the form of polyvinyl alcohol, is added to the etching solution. The process temperatures of the etching solution can be increased compared to traditional texturing methods, whereby the process duration can be shortened. The process control is simplified and the process stability is increased. A suitable texturing device for carrying out the method can also contain, in addition to a tank (6) for accommodating the etching solution (7) and a heater (9) for heating the etching solution (7) to at least 85°C, an optionally heatable drainage assembly (12) for draining the etching solution from the tank (6), a removal assembly (14, 15) for removing crystallized water-soluble polymers from the etching solution (7), and a circulating assembly (18) for circulating the etching solution.
A method for fabricating a photovoltaic element with stabilized efficiency is proposed. The method comprises the following steps: preparing a boron-doped, oxygen-containing silicon substrate; forming an emitter layer on a surface of the silicon substrate; and a stabilization treatment step. The stabilization treatment step comprises keeping the temperature of the substrate during a treatment time within a selectable temperature range having a lower temperature limit of 50° C., preferably 90° C., more preferably 130° C. and even more preferably 160° C. and an upper temperature limit of 230° C., preferably 210° C., more preferably 190° C. and even more preferably 180° C., and generating excess minority carriers in the silicon substrate during the treatment time, for example, by illuminating the substrate or by applying an external voltage. This method can be used to fabricate a photovoltaic element, e.g. a solar cell or a solar module having an efficiency which is stable at a value higher than that of photovoltaic elements fabricated without the stabilization treatment step.
B05D 5/06 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain multicolour or other optical effects
The invention relates to a method, to a system and to a computer program product for computer-supported communication, wherein the method comprises: providing primary image data for output via a first and a second monitor; capturing first secondary image data by means of a first camera, at least partially through the first monitor and/or mirrored on the first monitor; generating first combined image data by superimposing the first secondary image data with the primary image data; and outputting the first combined image data via the second monitor.
Bioconjugates are provided comprising a scaffold and an antigen, wherein the antigen is a peptide comprising a region from the β-amyloid peptide (AB). Such bioconjugates are useful for immunotherapy and diagnosis of Alzheimer's disease.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
A method for hosting a plurality of versions of memory pages in a storage system, wherein memory pages (Pp) are divided into memory page cells (PCp, c1,..., PCp, cn) and unique memory page cell identification information (c) is associated with each memory page cell, wherein in response to a revision (R) of a certain memory page (Pp), a counter (r) of revisions (Rp) and valid for the respective memory page is changed by a value and a memory page version (PVp, r) is logically managed by the storage system, and a memory page part (PPp, r) is physically stored in the storage system. The memory page part (PPp, r) comprises at lease one memory page cell (PCp, c) modified during the revision (Rr, p) and in response to the revision (Rr, p) of a memory page (Pp), a memory page version indicator (PVRr, p) is managed by the storage system, said indicator comprising m memory page part indicators (PPRrmax,p,..., PPRrmax-m+1,p) for the memory page parts (PPp,rmax,..., PPp, rmax-m+1), wherein m is a parameter value of m>0 that can be determined.
The invention relates to a method for storing a plurality of revisions (Rr) of data family parts which are linked tree structure-like and each have a number of tree-like linked data pages (Pr,p) with a central parent data page (PPr,0) and originating therefrom child data pages (PPr,x). For each revision (Rr), a main reference pointer (RRr) is provided on the parent data page (PPr,0) of the respective data page (Pr) in a separately stored list (NDLr,p). The data pages (Pr) have at least one page reference pointer (PPr,x) on logically linked child data pages (PPr,x). Node change information about a reference to changes of nodes of the structure of tree-like linked data family parts defining logically directly subsequently linked child data pages (PPr,x) are stored for each revision (Rr).
The present invention relates to ligands for selectively binding a non-complexed member of the β-amyloid polypeptide (Aβ)/human cystatin C (HCC)-complex, a pharmaceutical composition containing said ligands, methods for detecting non-complexed members of the Aβ/HCC-complex using said ligands as well as to a kit containing said ligands.
The present invention relates to cell free assays for measuring receptor activity, especially for measuring a constitutive or a non-constitutive activity of frizzled receptors and uses thereof. The present invention further concerns a method for measuring a constitutive or non-constitutive activity of a frizzled receptor and a method for obtaining an active frizzled receptor ligand.
FRAUNHOFER GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (Germany)
Inventor
Hahn, Giso
Haverkamp, Helge
Raabe, Bernd
Dastgheib-Shirazi, Amir
Book, Felix
Abstract
A method is presented for producing a silicon solar cell with a back-etched emitter preferably with a selective emitter and a corresponding solar cell. According to one aspect, the method comprises the following method steps: producing a two-dimensionally extending emitter (5) at an emitter surface of a solar cell substrate (21); applying an etching barrier (25) onto first partial zones (7) of the emitter surface; etching the emitter surface in second partial zones (9) of the emitter surface not covered by the etching barrier (25); removing the etching barrier (25); and producing metal contacts (17) at the first partial zones (7). During the method, especially during the etching of the emitter surface in the second partial zones, a porous silicon layer is advantageously produced, which is then oxidised. This oxidised porous silicon layer can subsequently be etched away together with any phosphorus glass (23) that may be present. The method makes use of conventional screen-printing and etching technologies and is thus compatible with current industrial production plants.
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
70.
DIAGNOSIS AND TREATMENT OF ALZHEIMER'S AND OTHER NEURODEMENTING DISEASES
Isolated, monoclonal, human, anti-/3-amyloid antibodies are provided which bind to dimeric forms of Ab with higher affinity than to monomelic forms of Ab and when bound to an Aβ polypeptide comprising Aβ(21 -37) shield Aβ(21-37) from proteolytic digestion. The antibodies were shown to inhibit fibril formation and reduce plaque size in vivo and to not bind brain vessel walls. Accordingly, the antibodies are useful in human and veterinary medicine for the treatment and prophylaxis of Alzheimer's disease and other neurodementing diseases. Methods of detecting or measuring the progression of a neurodementing disease also are provided.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
71.
METHOD FOR TEXTURING SILICON WAFERS FOR PRODUCING SOLAR CELLS
In a method for texturing silicon wafers for producing solar cells, the step of introducing a silicon wafer makes use of a texturing solution which is at a temperature of at least 80 degrees Celsius and which comprises water admixed with 1 percent by weight to 6 percent by weight of KOH or 2 percent by weight to 8 percent by weight of NaOH and with a surfactant or a surfactant mixture with less than 0.01 percent by weight. Very economic texturing can be carried out as a result.
The invention relates to a DNA-polymerase with increased mismatch discrimination which, compared to wild type variants, has at least one mutation in the amino acid sequence thereof, also to a host cell and to a method for producing the DNA-polymerase. The invention also relates to the use of the DNA-polymerase in diagnostic and molecular biological methods, and to a kit which contains the DNA-polymerase.
The present invention relates to a DNA polymerase with increased reverse transcriptase activity, which has, by comparison with the wild type variant at least one mutation in its amino acid sequence, and a host cell and a method for preparing the DNA polymerase. The present invention further relates to a method for identifying a nucleic acid and a kit which comprises the DNA polymerase.
A method for fabricating a photovoltaic element with stabilised efficiency is proposed. The method comprises the following steps: preparing a boron-doped, oxygen-containing silicon substrate; forming an emitter layer on a surface of the silicon substrate; and a stabilisation treatment step. The stabilisation treatment step comprises keeping the temperature of the substrate during a treatment time within a selectable temperature range having a lower temperature limit of 50 °C, preferably 90 °C, more preferably 130 °C and even more preferably 160 °C and an upper temperature limit of 230 °C, preferably 210 °C, more preferably 190 °C and even more preferably 180 °C, and generating excess minority carriers in the silicon substrate during the treatment time, for example, by illuminating the substrate or by applying an external voltage. This method can be used to fabricate a photovoltaic element, e.g. a solar cell or a solar module having an efficiency which is stable at a value higher than that of photovoltaic elements fabricated without the stabilisation treatment step.
The invention relates to a method for computerised processing of source data elements (32-40, 46-54) of a source data set (20), comprising the steps: input at least one request element, in particular a search string, determine a weighted interconnection (42, 44, 60) of the request data element to at least one source data element (34, 38, 40) of the source data set (20), in particular with at least one hit string from the source data set (20) and output of the at least one source data element (34, 38, 40) corresponding to a weighting (w12, w13, w34) for the weighted interconnection (42, 44, 60), preferably a hit probability for the request data element with the at least one source data element (34, 38, 40), wherein the weighting (w12, w13, w34) for the weighted interconnection (42, 44, 60) is determined from at least one associative interconnection (42, 44, 60) and a further method a system and a computer programme product.
The problem posed by both conventional and novel crystalline silicon solar cells is the electrical isolation of layers doped with p and n conductivity types. The invention solves said problem in a simple and elegant manner. A masking paste is applied locally to at least one side of the silicon substrate and is subsequently dried. A doping material diffusion is then carried out, whereby the conductivity type of the doping material is in opposition to that of the base doping of the crystalline silicon substrate. In one of the subsequent production steps of the solar cell, the electric contacts are applied in such a way that at least one section of said contacts is isolated electrically from the rest of the contact by the masking paste. The masking paste thus allows an electrical isolation of the two external contacts of a solar cell by preventing the diffusion of one doping material using said paste. Other methods that achieve the same results are substantially more complex and expensive to use.
77.
METHOD, SYSTEM AND COMPUTER PROGRAM FOR COMPUTATION OF OPTIMAL INDIVIDUAL DOSING REGIMEN, PARTICULARLY SUBJECT TO CLINICAL CONSTRAINTS
The present invention relates to a method for automatically determining an optimal individual dosing regimen of at least one drug for a patient suffering from a known disease, the optimal individual dosing regimen being optionally subject to at least one clinical constraint, wherein the method comprises the steps of: providing a mathematical model adapted to model a progression of said disease and an effect of the at least one drug on the progression of the disease, the model comprising individual model parameters associated with the patient; utilizing an empirical Bayesian estimation to automatically and numerically estimate the individual model parameters of the mathematical model utilizing patient data associated with the patient; automatically calculating an optimal individual dosing regimen for the mathematical model by solving an optimal control problem based on a desired progression of the disease, the estimated individual model parameters, and an initial guess for the dosing regimen; and adjusting the optimal individual dosing regimen to optionally account for at least one clinical constraint to yield the optimal individual dosing regimen subject to said at least one clinical constraint.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
ABSTRACT Described are to a biodegradable multilayer composite, in particular for food packaging, its use and a process for preparing said biodegradable multilayer composite.
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
B32B 27/20 - Layered products essentially comprising synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
B32B 27/22 - Layered products essentially comprising synthetic resin characterised by the use of special additives using plasticisers
patents
