Goods & Services

Advertising services to promote public awareness of medical issues; Advertising in periodicals, brochures and newspapers; Preparation of advertising campaigns; Data processing services in the field of healthcare; Development of promotional campaigns; Promotional marketing; On-line advertising and marketing services; Personnel management consultancy. Teaching; Education services relating to health; Team building (education); Adult education services relating to medicine; Training of non-medical staff in the care of children; Education and instruction; Advanced training; Providing online electronic publications, not downloadable; Electronic publishing services; Publication of newspapers, periodicals, catalogs and brochures; Publishing of medical publications; Providing electronic publications; Issue of publications; Provision of information relating to publishing; Publication of text books; Publication of printed matter relating to education; Online publication of electronic books and journals; Publication of electronic books and periodicals on the Internet; Organising of meetings in the field of education; Workshops for training purposes; Provision of play facilities for children; Workshops for educational purposes; Arranging of workshops and seminars; Arranging, conducting and organisation of workshops; Arranging and conducting of workshops [training]; Online interactive entertainment; Providing on-line publications; Organisation of Webinars.

Abstract

characterized bycharacterizedcharacterized by comprising nanochannels that control the sample (20) access to the working electrode; and d) means for determining the difference in the electrochemical state between the working electrode and the second electrode. In the system, the presence and/or concentration is determined from the change in the difference in the electrochemical state caused by the blockage of the nanochannels by the presence of the nanoparticles in the sample. The disclosure also refers to uses and methods thereof.

IPC Classes  ?

• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

The present invention describes a method for identifying free radicals present in a pathological process suffered by an individual, comprising: (a) determining the absorption spectrum of haemoglobin (Hb) between 500 and 1000 nm in a sample of venous blood isolated from the individual, and (b) comparing the absorption spectrum obtained in step (a) with the absorption spectrum of Hb between 500 and 1000 nm obtained in a sample of venous blood from a control individual. This method is applicable in the diagnosis of pathologies such as endometriosis.

IPC Classes  ?

• G01N 33/72 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood pigments, e.g. hemoglobin, bilirubin
• G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light

Abstract

A method for obtaining secretomes from platelets and the secretome uses in regenerative medicine, in the treatment of diseases, including cell therapy, and in vitro cell culture. This method is developed with the aim of obtaining platelet-derived bio-products enriched in platelet granular cargo, rich in growth factors, and depleted of other platelet-derived molecules and plasma for universal use. The method avoids the use of platelet inhibitors or temperature-shock during the process, assuring the integrity of the platelet biological source. Furthermore, the potential processing of the product would allow additional clinical applications and solve storage limitations. This method and the characterization thereof of secretomes at the molecular level in health and disease will contribute to the identification of biomarkers for disease diagnosis and prognosis.

IPC Classes  ?

• C12N 5/078 - Cells from blood or from the immune system
• A61K 9/14 - Particulate form, e.g. powders
• A61K 35/19 - PlateletsMegacaryocytes
• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

nrr , nii Qrr , Qii i ) and normalized three-dimensional magnetization vector (I) are accurately obtained.

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties

Abstract

The present invention enables identifying each measured value of the input variables (voltage, current and phase shift angle) of the status of the system (1). Based on the time evolution of the statuses of the system (1), it enables identifying sequences or groups of statuses that describe aggregated behaviours of said system. In particular, it comprises the steps of: training artificial intelligence models; capturing analogue voltage, current and phase shift angle signals (2); synchronously predicting the discrete status (5) of the system (1) at each moment; sequencing and segmenting the discrete statuses (5) of the system (1), obtaining a set of subsequences (6); and obtaining a set of behaviour trends of the system (1) based on the subsequences (6), their duration and repeatability.

IPC Classes  ?

• G06N 20/00 - Machine learning
• G06N 5/00 - Computing arrangements using knowledge-based models

Abstract

The invention relates to a device for the demonstration and experimental study of the boiling regimes of a liquid, comprising a container (1) containing the liquid, an electrical resistor element (4), an electrical power supply (6), a temperature sensor (8), an image sensor (11), first means (7) for viewing the voltage, current or power, and second means (13) for viewing the image captured by the image sensor (11). The device of the invention is suitable for use in sectors involving the design, production or use of devices for the study, control or demonstration of the boiling regimes of a liquid (e.g. petrochemistry), in the steam-based energy production sector, in the thermal systems sector, in the sector for the production, treatment and distribution of water, in the sector for the production of additives or solutes, or in the sector for the surface treatment of materials.

IPC Classes  ?

• G01N 25/08 - Investigating or analysing materials by the use of thermal means by investigating changes of state or changes of phaseInvestigating or analysing materials by the use of thermal means by investigating sintering of boiling point

Abstract

The invention relates to a portable wastewater sample collection device and method that automatically extracts and filters wastewater collected directly from urban sewage collectors using hydraulic equipment and a filter cartridge that recirculates the water collected by a wastewater tank until obtaining a volume of water with a specific concentration to subsequently carry out the viral analysis of the filtered wastewater sample using a qRT-PCR assay.

IPC Classes  ?

• G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
• G01N 1/40 - Concentrating samples

Abstract

An analytical method makes use of an oxygen-containing source having a predetermined content of an isotope of oxygen zO, which is not the same as natural composition and distribution of oxygen isotopes, to detect and/or quantify oxygen in oxidizable compound(s). The analytical method allows detecting and/or quantification with relatively high precision and accuracy oxygen in oxidizable compound(s), even at low content. The method is easy to implement and can be used for in-line analysis.

IPC Classes  ?

• G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods
• G01N 31/12 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using combustion

Abstract

The present invention relates to a material comprising a membrane extracted from eggshell, coated with a layer of calcium phosphate. The invention also relates to a method for producing the material and to the use thereof as a pulp capping or bony tissue regenerator.

IPC Classes  ?

• A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• A61K 35/57 - BirdsMaterials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
• A61K 6/50 - Preparations specially adapted for dental root treatment
• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives
• A61K 6/75 - Apatite

Abstract

The present invention relates to methods for the diagnosis, monitoring, and evaluation of treatments for lung overdistension, based on the determination of specific miRNAs levels, and subsequent comparison with other reference values. Furthermore, the invention also relates to kits and uses for said purposes.

IPC Classes  ?

• B60H 1/00 - Heating, cooling or ventilating devices
• B60H 1/32 - Cooling devices
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

n vitron vitro cell culture. This method is developed with the aim of obtaining platelet-derived bio-products enriched in platelet granular cargo, rich in growth factors, and depleted of other platelet-derived molecules and plasma for universal use. The method avoids the use of platelet inhibitors or temperature-shock during the process, assuring the integrity of the platelet biological source. Furthermore, the potential processing of the product would allow additional clinical applications and solve storage limitations. This method and the characterization thereof of secretomes at the molecular level in health and disease will contribute to the identification of biomarkers for disease diagnosis and prognosis.

IPC Classes  ?

• A61K 35/19 - PlateletsMegacaryocytes
• A61M 1/02 - Blood transfusion apparatus
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• B01D 21/26 - Separation of sediment aided by centrifugal force
• C12N 5/078 - Cells from blood or from the immune system
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

The present invention relates to three-dimensional (3D) graphene aerogels which exhibit ultra-low density, large macroporosity and high electrical conductivity values and its process of obtainment. Said 3D graphene aerogels with controlled porosity and high electrical conductivity are extremely attractive for their application in several fields, especially as electrode materials for electrochemical devices such as supercapacitors, batteries, fuel cells and sensors. Therefore, the present invention also refers to an electrode for electrochemical energy devices comprising said 3D graphene aerogels.

IPC Classes  ?

• C01B 32/198 - Graphene oxide
• C01B 32/00 - CarbonCompounds thereof
• B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons

Abstract

The present disclosure relates to halogenated fatty acid lactylates, in particular to chlorinated fatty acid lactylates. The present disclosure relates to halogenated fatty acid lactylates, in particular to chlorinated fatty acid lactylates. The halogenated fatty acid lactylates now disclosed have antimicrobial and/or antibiofilm activity towards healthcare associated microbial infections.

IPC Classes  ?

• C07C 69/63 - Halogen-containing esters of saturated acids
• A61P 31/04 - Antibacterial agents
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 29/16 - Biologically active materials, e.g. therapeutic substances

Abstract

The present disclosure relates to halogenated fatty acid lactylates, in particular to chlorinated fatty acid lactylates. The halogenated fatty acid lactylates now disclosed have antimicrobial and/or antibiofilm activity towards healthcare associated microbial infections.

IPC Classes  ?

• C07C 69/63 - Halogen-containing esters of saturated acids
• A61K 31/23 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms

Abstract

The invention relates to a system and method for antenna diagnosis, which comprises a probe antenna (1) that is moved manually by an operator relative to the antenna being measured (3) describing an arbitrary path (7) that collects the radiated signal (2). It also comprises a radiofrequency unit (4) which measures the properties of said signal, a positioning means (5) for positioning the probe antenna (1), and a processing system which diagnoses the antenna being measured (3). The method comprises defining a reference surface (15), moving the probe antenna (1) close to the antenna being measured (3), homogenising the sampling, processing the information and performing a diagnosis by calculating the tangential component of the field. The invention is useful in industries where antenna diagnosis is required, such as in the communications industry. It is of particular interest in 5G networks.

IPC Classes  ?

• G01R 29/10 - Radiation diagrams of antennas

Abstract

An airborne system and method for the characterization and measurement of radiating systems or antennas (5), including: an aerial module (1) including a unit for measuring electromagnetic emissions (11), which captures the electromagnetic field (E) radiated by the radiating system or antenna (5), and a positioning and guiding system (13) with an accuracy equal to or less than 3 cm; and a ground station (2) including a unit (23) for processing the electromagnetic emission measurements, which processes the measurements using a set of algorithms for processing electromagnetic emission measurements (25). Also, a method for measuring and characterizing radiating systems or antennas (5). The invention is suitable for use in sectors that require antennas to be characterized and measured, such as, for example, radar and radio navigation facilities, terrestrial- and satellite-based telecommunications systems, or terrestrial broadcasting facilities.

IPC Classes  ?

• G01R 29/10 - Radiation diagrams of antennas
• H04B 17/10 - MonitoringTesting of transmitters
• B64C 39/02 - Aircraft not otherwise provided for characterised by special use
• G08G 5/00 - Traffic control systems for aircraft
• H04B 7/185 - Space-based or airborne stations

Abstract

Airborne systems and methods for the detection, location and obtaining of images of buried objects and for the characterization of the composition of the subsoil. The systems comprise at least one aerial module with a radar unit that emits and/or captures radar signals and a positioning and guidance system with an accuracy equal to or less than 3 cm, and a ground station with a flight control system and a radar signal processing unit where radar signal processing algorithms are applied. The invention also comprises a method for the detection, localization and obtaining of images of buried objects and a method for the characterization of the composition of the subsoil. Applicable in sectors where it is necessary to perform the detection of buried objects, as for example in civil applications (detection of antipersonnel mines), pipeline inspection or in archaeology.

IPC Classes  ?

• G01S 13/88 - Radar or analogous systems, specially adapted for specific applications
• G01S 13/90 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging using synthetic aperture techniques
• G01C 11/00 - Photogrammetry or videogrammetry, e.g. stereogrammetryPhotographic surveying
• G01S 7/00 - Details of systems according to groups , ,
• G01S 7/40 - Means for monitoring or calibrating
• G01S 19/43 - Determining position using carrier phase measurements, e.g. kinematic positioningDetermining position using long or short baseline interferometry
• B64C 39/02 - Aircraft not otherwise provided for characterised by special use

Abstract

The invention relates to an airborne system and method for the characterisation and measurement of radiating systems or antennas (5), comprising: an aerial module (1) including a unit for measuring electromagnetic emissions (11), which captures the electromagnetic field (E) radiated by the radiating system or antenna (5), and a positioning and guiding system (13) with an accuracy equal to or less than 3 cm; and a ground station (2) including a unit (23) for processing the electromagnetic emission measurements, which processes the measurements using a set of algorithms for processing electromagnetic emission measurements (25). The invention also relates to a method for measuring and characterising radiating systems or antennas (5). The invention is suitable for use in sectors that require antennas to be characterised and measured, such as, for example, radar and radio navigation facilities, terrestrial- and satellite-based telecommunications systems, or terrestrial broadcasting facilities.

IPC Classes  ?

• G01R 29/10 - Radiation diagrams of antennas

Abstract

The invention relates to a device for collecting waste in patients having an elimination stoma, which comprises a bag (1) disposed inside the body of a patient with a colostomy or ileostomy, and which collects waste, preventing all the inconveniences of external bags. The device also comprises a self-expanding element (2) for inserting and adequately positioning the bag (1), and means for attaching to the patient's body. The device of the invention can be attached to the adhesives currently used to secure external bags on patients whose skin is not irritated by the adhesive, or can self-attach to the stoma in the manner described in one of the preferred embodiments. The device can be used in fields related to the design, production and use of devices for medical treatments or other health therapies for dispensing drugs or collecting samples.

IPC Classes  ?

• A61F 5/44 - Devices worn by the patient for reception of urine, faeces, catamenial or other dischargeColostomy devices
• A61F 5/445 - Colostomy devices
• A61F 5/448 - Means attaching bag to seal ring

Abstract

A device for collecting and transferring samples in anaerobiosis, comprising a vessel (1) with an opening (2), and a closure (4) for covering the opening (2), in which the closure (4) incorporates a manually operated activator plug (6) that releases an activator element contained in a bag (8) to start a chain of reactions determined by a reagent material (13) capable of creating an anaerobic atmosphere inside the vessel (1). The device is preferably designed for the case in which said samples are stool, of human or animal origin, with the aim of preserving the viability of the gut microbiota and being able to proceed with their later revival in the laboratory.

IPC Classes  ?

• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• C12M 1/00 - Apparatus for enzymology or microbiology
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The invention relates to airborne systems and methods for the detection, localisation and production of images of buried objects and for the characterisation of the composition of the subsurface. The systems comprise at least one aerial module (1) with a radar unit (11) that emits and/or captures radar signals, a positioning and guidance system (13), the accuracy of which is equal to or less than 3 cm, and a ground station (2) with a flight control system (21) and a unit for processing radar signals (23) where radar signal processing algorithms (25) are applied. The invention also relates to a method for the detection, localisation and production of images of buried objects, and to a method for characterising the composition of the sub-surface. The invention is applicable in sectors where the detection of buried objects is required, for example in civil applications (detection of anti-personnel mines), inspection of tubing or in archeology.

IPC Classes  ?

• F41H 11/13 - Systems specially adapted for detection of landmines
• G01S 13/88 - Radar or analogous systems, specially adapted for specific applications

Abstract

The present invention concerns an analytical method that makes use of an oxygen-containing source having a predetermined content of an isotope of oxygen (zO), which is not the same as natural composition and distribution of oxygen isotopes, to detect and/or quantify oxygen in oxidizable compound(s). The analytical method allows detecting and/or quantification with relatively high precision and accuracy oxygen in oxidizable compound(s), even at low content. The method is easy to implement and can be used for in-line analysis.

IPC Classes  ?

• G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods
• G01N 31/12 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using combustion

Abstract

The present invention relates to an in vitro method for the prognosis or prediction of the response to treatment with anti-psychotic drugs in subjects who have suffered first episode psychosis (FEP), and specifically to the use of the expression value, in a biological sample isolated from said subjects, of the ratio formed by two of the isoforms – active isoform and truncated isoform – of the receptor (TrKB) of the nerve growth factor BDNF, named TrKB-FL and TrkB-T, respectively. The present invention also describes kits and uses of same to implement the method of the invention.

IPC Classes  ?

• G01N 33/536 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a recombinant nucleic acid comprising a sequence encoding a protein with at least 70% with the sequence SEQ ID NO: 1 and a sequence encoding a protein with at least 70% with the sequence SEQ ID NO: 4. Furthermore, that sequence may comprise sequences of other genes for the synthesis of polyphenols. In the present invention the utility of such gene constructs in the synthesis of polyphenols, particularly stilbenes, chalcones, flavanones, isoflavones, flavones, flavonols, dihydroflavonols, dihidroflavanoles, anthocyanidins and their derivatives, is shown.

IPC Classes  ?

• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/10 - Transferases (2.)
• C12N 9/88 - Lyases (4.)
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12P 7/22 - Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
• C12P 7/42 - Hydroxy carboxylic acids

Abstract

The invention relates to a method for assessing non-classical cardiovascular risk by means of detection of anti-high-density-lipoprotein autoantibodies, to an immunosensor, and to a kit for the application thereof. The method comprises bringing a sample of the subject into contact with human HDL particles in conditions such that a detectable specific antigen-antibody union may occur, and stratifying the cardiovascular risk of the subject by comparing the result obtained in the analysis of the sample with those obtained in the healthy population. The invention is applicable in the sectors of biotechnology and pharmacology and in that of medicine and clinical diagnostics, and more specifically in the assessment of cardiovascular risk to prevent diseases using biomarkers in different groups of patients.

IPC Classes  ?

• G01N 33/49 - Physical analysis of biological material of liquid biological material blood

Abstract

Marker of ocular pathologies. The invention relates to an in vitro method for diagnosing or determining the degree of an ocular surface pathology, to an in vitro method for monitoring the effect of a treatment administered to a patient diagnosed with an ocular surface pathology, and to an in vitro method for selecting a subject to undergo corneal refractive surgery based on the determination of the heparanase activity in a sample of said subject. The invention also relates to the use of the heparanase activity as a diagnostic marker of an ocular surface pathology, as a marker for determining the degree of said pathology, as a marker for monitoring the effect of a treatment administered to a patient diagnosed with an ocular surface pathology, and to the use of the heparanase activity in order to select a subject to undergo corneal refractive surgery.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase

Abstract

The invention relates to a method for the absolute quantification of peptides by means of tandem mass spectrometry, and the uses thereof using peptides that are isotopically enriched in stable isotopes that exhibit spectral overlapping with the peptide of natural isotopic abundance; monitoring multiple reactions at low resolution in the first analyser of a tandem mass spectrometer; and multiple linear regression. The method is also suitable for indirectly determining proteins after the hydrolysis of the proteins using enzymes, the selection of one or a number of peptides that are characteristic of same, and the determining of these peptides in an absolute manner. The invention is suitable for application in fields requiring the quantification of proteins and/or peptides in a sample, such as in biological fluids or in cell cultures, for example in the fields of agriculture, chemistry, pharmacy, biomedicine or food safety.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to an endocavitary mechanical distractor device comprising a set of rigid and pivoting rods (6), a front head (1), an inlet port (3), transmission means (2), and actuating means (10). The particular configuration of the rods (6) is such that, once they have been rotated, a working space is created that can be accessed via the inlet port (3). The invention provides a device for providing assistance in surgical procedures, for medical exploration or for dosing medicines, that is particularly suitable for transanal endoscopic microsurgery (TEM) or urogynaecological treatments. The device can be employed in fields involved in the design, production and use of devices for surgery, medical exploration or dosing medicine, such as the technical field of human or animal medicine, that of machinery and mechanical equipment, or that of chemistry and pharmacy.

IPC Classes  ?

• A61B 1/32 - Devices for opening or enlarging the visual field, e.g. of a tube of the body
• A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors
• A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes

Abstract

The invention relates to an in vitro method for the simultaneous detection of Campylobacter jejuni, Cronobacter sakazakii, an enterohemorrhagic strain of Escherichia coli, Listeria monocytogenes, Salmonella spp. and Shigella spp. in a sample, said method comprising: a) isolating the DNA of said sample; b) carrying out a multiplex PCR on the DNA isolated in step a) with a group of primer pairs designed for this purpose; and c) detecting the amplification products obtained in step b). The invention also relates to a group of primer pairs especially designed for implementing said in vitro method, and to a kit comprising the above-mentioned group of primer pairs.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The invention relates to a method for the production of various chiral esters with a high enantiomeric purity, by means of catalytic hydrogenation reactions of enol esters. The invention also relates to the chiral esters obtained and to the use thereof for producing, by means of hydrolysis, the corresponding chiral 2-alkanols to which the present invention also relates.

IPC Classes  ?

• C07C 69/66 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
• C07C 69/732 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
• C07C 67/283 - Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
• C07B 53/00 - Asymmetric syntheses
• B01J 23/46 - Ruthenium, rhodium, osmium or iridium

Abstract

Cryoablation cell with temperature control of the sample (5), comprising a removable top cover (2) with a window (3) that is transparent to the laser, and a base of the cell (4) with an internal cooling system (12). The system also comprises an external cooling system (16), a temperature sensor (21), temperature control means (22) and an external ventilation system (27). The cell may be used in combination with other devices, such as a laser ablation system coupled to an inductively coupled plasma system with detection by optical emission or mass spectrometry. The invention may be used in sectors involving the design, production or use of ablation cells, such as mechanical machinery and equipment, geology, biology, medicine, archaeology and chemistry.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

The invention concerns a method and template with geometric features for checking and calibrating measurements with articulated arms for measuring using coordinates, which comprises solid spheres, virtual spheres, planes, inner cylinders (44), (45) and outer cylinders (42), (43), (58), (59) and inner cones (48), (49) or outer cones. The invention concerns a particular selection and spatial arrangement of geometric features which enable numerous geometric and dimensional tolerances to be produced. The measuring of the geometric features and comparison thereof with reference values in different spatial positions enable both the measuring technique and apparatus to be evaluated, such that operatives can be trained or accredited with respect to their use. The invention also concerns a method for calibrating and verifying by means of this template. The invention can be applied in sectors in which calibration templates are designed, produced and used, such as industrial dimensional metrology preferably with portable or fixed machines which measure using coordinates.

IPC Classes  ?

• G01B 5/008 - Measuring arrangements characterised by the use of mechanical techniques for measuring coordinates of points using coordinate measuring machines
• G01B 21/04 - Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant for measuring length, width, or thickness by measuring coordinates of points

Abstract

The present invention is a method of predicting the evolution of a patient suffering of CLL comprising the steps of determining in a biological sample obtained from said patient the DNA methylation level of site cg11472422 of the lymphocyte population of said sample, comparing the result of said methylation level with a standard wherein the methylation level is indicative of a CLL outcome subgroup, and predicting the evolution of said patient evaluating the result of the comparison. In a preferred embodiment, the method comprises additionally, the determination of the methylation level of at least one site selecting from any of the following:cg03462096, cg17014214, cg00869668, cg09637172 or any combination thereof.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The invention relates to single-stranded DNA molecules, also called aptamers, that are able to recognise and bind specifically to gluten. The invention also relates to a method for recognising, capturing and/or detecting gluten using said aptamers, and to a kit comprising said aptamers.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Abstract

Beverage-preparation capsules with deflectors which contain a food preparation for preparing beverages by means of a leaching process, which comprise at least one deflector (4) in the inner part of the lower wall (3) thereof. The present invention likewise relates to a beverage-preparation capsule, which comprises at least one floating deflector (6) arranged within the food preparation contained in the interior thereof. The invention can be used in those sectors that involve the design, manufacture, production or use of beverage-preparation capsules, such as, for example, the food industry, the beverages and tobacco industry, the chemicals industry, the rubber and plastics industry, the metal-goods-manufacturing industry and the trade and hotel industry.

IPC Classes  ?

• B65D 85/804 - Disposable containers or packages with contents which are infused or dissolved in situ

Abstract

The invention relates to a device for the continuous movement of a structure by means of a friction force, said device comprising drive mechanisms (19) configured to rotate pinions (6) in two directions, that in turn entrain traction chains (4); and a chain of highly rigid supporting links (2) for supporting vertical loads, connected to the traction chains (4) by means of bolts (3) that support vertical and horizontal loads. The ends of said bolts (3) receive said traction chains (4) and wheels (5) that are designed to support vertical loads and are in contact with said traction pinions (6), the supporting links (2) remaining in the central area of the bolts (3).

IPC Classes  ?

• E01D 21/00 - Methods or apparatus specially adapted for erecting or assembling bridges
• E01D 21/06 - Methods or apparatus specially adapted for erecting or assembling bridges by translational movement of the bridge or bridge sections

Abstract

The invention relates to a system for launching a structure, comprising: a first deck (4) produced and mounted by means of the successive addition of voussoirs and designed to be longitudinally moved up to stacks by means of at least one pushing system (18); and a second deck (6) placed on the upper part of the first deck, or lower deck (4), and securely connected to said lower deck (4) by means of dismountable connecting means (8). The second deck, or upper deck, is designed to be the last span of the structure and, when securely fixed to the lower deck (4), is designed to be pushed over the stacks together with the lower deck. The connection means (8) are designed to transmit the force from the lower deck to the upper deck, in such a way that the two decks work together in a joint manner, collaborating in order to resist the overall shear, flexion and torsion forces that are produced during the launching. The invention also relates to a method for launching a structure by pushing.

IPC Classes  ?

• E01D 21/06 - Methods or apparatus specially adapted for erecting or assembling bridges by translational movement of the bridge or bridge sections

Abstract

Method for the microbial decontamination of milk or whey using deionization by means of a semipermeable membrane, without alteration to the physical/chemical, nutritional, bioactive or organoleptic properties of the natural product. The method is of use in sectors of the food industry requiring a non-thermal pasteurization method, particularly the milk-product-processing industry.

IPC Classes  ?

• A23C 3/00 - Preservation of milk or milk preparations

Abstract

The present invention relates to the isolation, cloning and sequencing of the group of genes involved in the biosynthesis of coly-mycin by Streptomyces spp. CS40, and to the use of said genes to increase the production of coly-mycin and/or associated analogous compounds or derivatives by means of productive strains. Said compounds produced in the present invention can be used to treat several diseases, such as cancer, neuro-degenerative diseases and infectious diseases.

IPC Classes  ?

• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• A61P 35/00 - Antineoplastic agents

Abstract

A robot platform for climbing posts comprising a frame (1) formed by four semicircular sectors hinged in pairs in parallel planes. It also comprises two joints (6), including a detachable joint and a hinged joint that keep together the frame (1) and allow closing the platform around the post. Moreover, the robot platform comprises a cover (7) that houses accessories, and at least three radially arranged wheels (2) in contact with the post surface. The robot platform also comprises a pressure mechanism (3) that urges the wheels against the post, motive means, transmission means (8) and remote control means (12) for the robot. The robot platform can be used in the fields in which lifting robot platforms are designed, manufactured, produced or used, such as the mechanical machinery and equipment industry, the electrical, electronic and optical tools and equipment industry, and the transport equipment industry.

IPC Classes  ?

• A63B 27/00 - Apparatus for climbing poles, trees, or the like
• B66B 9/02 - Kinds or types of lifts in, or associated with, buildings or other structures actuated mechanically otherwise than by rope or cable
• B62D 57/024 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members specially adapted for moving on inclined or vertical surfaces

Abstract

Open-face- or jet-type protective helmet and uses thereof, comprising a shell (1), a fold-down visor (2) for protecting the eyes, the face and the jaw, totally or partially, a deployable protection and retention system housed in the inner or outer part of the shell (1), which in turn comprises at least two rigid or semi-rigid protective devices (3) that are deployed after an impact and retain and protect the user's head, means for transmission of the impact variable from the visor (2) to the protection and retention system, and a system (14) for connecting the visor (2) to the transmission means. The present helmet can be used in those sectors where helmets are designed, produced or used such as, for example, the sectors of agriculture, machinery and mechanical equipment, electric, electronic and optical material and equipment, material for transport or material for individual protection of people.

IPC Classes  ?

• A42B 3/04 - Parts, details or accessories of helmets
• A42B 3/18 - Face protection devices
• A42B 3/32 - Collapsible helmetsHelmets made of separable parts

Abstract

Procedure for isolating genes involved in the biosynthesis of streptolydigin, molecules of DNA, genetic manipulation of the route and uses thereof. The invention provides a procedure for isolating and purifying a fragment of nucleic acid containing the gene grouping of the streptolydigin biosynthesis route. Additionally it provides molecules of nucleic acid, molecules of recombinant nucleic acid, polypeptides encoded by these molecules, host cells containing these molecules and uses thereof. Moreover it provides a process for increasing production of tetramic metabolites in a bacterial host, a process for generating derivatives of streptolydigin or precursors of streptolydigin and uses thereof. Furthermore an object of the invention is a recombinant strain of Streptomyces lydicus and the derivatives of streptolydigin produced thereby. Applicable in the obtainment of superproducer strains of streptolydigin or derivatives of streptolydigin for isolation and utilisation thereof, inter alia in the pharmaceutical or chemical sector.

IPC Classes  ?

• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12P 19/28 - N-glycosides

Abstract

The present invention comprises a method for marking and identifying manufactured articles, substances and organisms (referred to below as "products"), based on the addition to the product to be marked of a known mixture of two or more isotropic profiles of a single chemical element that are enriched in different stable isotopes. Identification thereof may be performed by measuring the ratio of molar fractions between those isotropic profiles present in the product using mass spectrometry. The present invention also relates to the use of the product marked by means of the above method for marking other products which are derived therefrom or which use it in their composition. The present invention is applicable to the concealed marking of manufactured articles, substances and organisms in the sectors of pharmaceuticals, explosives, jewellery, works of art, plants, foodstuffs and addictive drugs, among other things.

IPC Classes  ?

• G01N 33/22 - FuelsExplosives
• G01N 33/02 - Food
• G01N 33/15 - Medicinal preparations

Abstract

The frequency-selective surface (FSS) comprises a periodic metallization structure (D) formed by the repetition of the metallization of a unit cell on a dielectric substrate (Y). The planar artificial magnetic conductor (AMC) comprises at least one FSS situated on a conductive earth plane (F). The invention can be used in communication systems, particularly in those which require reduced sizes such as portable systems, for example for implementing filters or as an earth plane for antennas. The use of the invention in passive tagging in radio-frequency identification systems in UHF bands on metals or in environments in which metals are present, such as hospital logistics, airport logistics, station logistics, the manufacturing industry, transport, the automotive industry, the food industry, and the metallurgical industry among others, is particularly interesting.

IPC Classes  ?

• H01Q 1/38 - Structural form of radiating elements, e.g. cone, spiral, umbrella formed by a conductive layer on an insulating support

Abstract

The invention relates to the enzymatic resolution of derivatives of cis- and trans-cyclopentane-1,2-diamines in order to obtain enantiomerically pure or enriched compounds, a method for preparing the starting materials for this method, the products of said method and the transformation thereof into products of commercial interest.

IPC Classes  ?

• C07C 211/36 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
• C07C 271/24 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
• C07C 233/41 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
• C07B 53/00 - Asymmetric syntheses

Abstract

Glycosylated indolecarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by means of fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to produce rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing medicaments that are of use in the treatment of tumour, neurological and inflammatory diseases.

IPC Classes  ?

• C07H 19/23 - Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups
• C12P 19/28 - N-glycosides
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to oviedomycin derivatives, the method for obtaining same and the use thereof. The invention relates to oviedomycin derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to produce the oviedomycin derivatives. The invention further relates to bacterial strains that can be used to produce oviedomycin derivatives. Said oviedomycin derivatives can be used in the field of human health, specifically to produce drugs for the treatment of tumour diseases.

IPC Classes  ?

• C07C 50/36 - Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
• C07C 49/747 - Unsaturated compounds containing a keto group being part of a ring containing hydroxy groups containing six-membered aromatic rings
• C07C 49/753 - Unsaturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 15/76 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for ActinomycesVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Streptomyces
• C12N 9/10 - Transferases (2.)
• A61P 35/00 - Antineoplastic agents
• C12R 1/47 - Streptomyces albus

Abstract

Method and system for producing fresh milk with properties that are differentiated on the basis of separation during milking, which are, respectively, a set of methods that comprise measurement of certain parameters of the milk in the pipe where differentiation is to take place, comparison with target values or reference values to be achieved and diversion of the flowing milk towards other pipes that convey same towards different storage points; and the set of units that implement the above method and that comprises measurement sensors in line and/or in the tanks for indicating the values of the target differentiation parameters, units for estimating other parameters, a calculation unit that will give the diversion orders and a set of actuators capable of diverting the milk towards other pipes. This invention applies to milk-production facilities.

IPC Classes  ?

• A01J 5/007 - Monitoring milking processesControl or regulation of milking machines
• A01J 5/013 - On-site detection of mastitis in milk

Abstract

The invention relates to an in-line sensor and a system for obtaining the fat content of milk, respectively: a hollow device similar to any pipe through which the milk can flow and provided with a light-transparent hole and a plate located at a short distance from, and parallel to said hole, such that milk always occupies all of the section extending from the hole to the plate; and a system capable of producing the corresponding excitation light in near infrared or the visible, below 1000 nm, and of collecting the light reflected by the milk. The fat content can be obtained at all times by applying a quadratic or simple linear calculation and is provided by means of an analog or digital signal. Control actions can also be supplied using digital outputs. The invention is suitable for use in milk production facilities.

IPC Classes  ?

• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light

Abstract

The present invention provides compounds characterised by the formula (l), where each of the substituent radicals is described in the report. The invention also describes the use of said compounds in the treatment of various diseases, including: cancer or tumoral processes in general, Paget's disease, hypercalcaemia, hypercalciuria and neurological diseases (inter alia, Parkinson's, Alzheimer's, Huntington's).

IPC Classes  ?

• C07H 15/24 - Condensed ring systems having three or more rings
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 15/76 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for ActinomycesVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Streptomyces
• C12N 9/10 - Transferases (2.)
• A61P 35/00 - Antineoplastic agents
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• A61P 19/00 - Drugs for skeletal disorders
• A61P 25/00 - Drugs for disorders of the nervous system
• C12R 1/465 - Streptomyces

Abstract

The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological ageing.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 31/663 - Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
• A61P 17/00 - Drugs for dermatological disorders
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The present invention is a method for producing a modular, intelligent switch, which is bi-directional in terms of current and electrical voltage, applying principally to power supplies. The most noteworthy characteristics of this novel device is that it incorporates the various stages of power, control and protection of the circuits, in order to guarantee bidirectionality in terms of voltage and current, together with the circuits and control algorithms required for secure, robust switching. Its modular nature also provides the user with a combination of choices for forming complex circuits with a wide range of practical applications, such as matrix power converters, and also easy replacement in the event of repair.

IPC Classes  ?

• H02M 1/096 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters for the simultaneous control of series or parallel connected semiconductor devices the power supply of the control circuit being connected in parallel to the main switching element

Abstract

The invention relates to the quantification of organic compounds originating from a chromatographic system that does not involve the use of patterns, comprising the continuous conversion of the carbon of said compounds into carbon dioxide (CO2), involving a chemical reaction and the mixing of same, before or after separation, with a known constant flow of a carbon compound, preferably CO2, which is enriched with carbon isotope -13 (13C). The mixture is introduced into a mass spectrometer in which the isotopic ratio 12C/13C is continuously measured either in the carbon or in any characteristic ion originating from same. Said isotopic ratio is converted into a carbon mass flow measurement using in-line isotopic dilution.

IPC Classes  ?

• G01N 30/72 - Mass spectrometers
• G01N 31/12 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using combustion

Abstract

The new proposed technique makes it possible to neutralise and dewax oils in a single phase by modifying the mode of implementation of neutralising deodorization or physical refining; it also includes the modification of the deodorising agents used, either continuous, semicontinuous or discontinuous. The method is based on distillation with entrainment of steam or free fatty alcohol vapours present in the oils or produced by cleavage of the waxes contained in the same. In order to facilitate distillation, esterification is prevented and reflux of the components to be distilled is avoided.

IPC Classes  ?

• C11B 3/14 - Refining fats or fatty oils by distillation with the use of indifferent gases or vapours, e.g. steam

Abstract

The invention relates to a micro-organism carrier for use in fluid-bed wastewater treatment plants. The inventive carrier comprises a preferably-hollow cylindrical body (1) with at least one helical flange (2) disposed therearound, which favours the creation of a biofilm and which facilitates the flow of water through and around the carrier in order to promote contact and the decomposition of the contaminant elements by the biofilm. In addition, the helical flanges (2) minimise the surface exposed to contact, thereby preventing the biofilm from detaching upon coming into contact with another carrier.

IPC Classes  ?

• C02F 3/10 - PackingsFillingsGrids
• B01J 19/30 - Loose or shaped packing elements, e.g. Raschig rings or Berl saddles, for pouring into the apparatus for mass or heat transfer