C07C 51/29 - Preparation of carboxylic acids or their salts, halides, or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
C07C 61/125 - Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
C07C 67/10 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
C07C 69/753 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
An ink may be provided that includes a two-dimensional WS2 nanosheet and an organic solvent, such as water, and may be free of protective molecules and surfactants. Circuits may be provided that include this ink disposed onto a surface of a substrate (such as a flexible substrate) in various patterns, including, e.g., a superconducting qubit. The ink may be formed by sonicating, then centrifuging at a first speed, a sulfuric acid-KxWS2 solution, where x=0.3˜0.7, removing any supernatant from the centrifuged first suspension and replacing with water and sonicating the resulting WS2-water suspension, then centrifuging the result at a speed slower than the first speed, and using an upper portion of the resulting suspension.
H05K 1/09 - Use of materials for the metallic pattern
H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material
4.
METHODS, DEVICES, AND SYSTEMS FOR MULTIPHASE COUPLED INDUCTORS
Tile present disclosure relates to systems and methods for multiphase coupled inductors. The multiphase coupled inductor includes a magnetic ladder core assembly. The magnetic ladder core assembly includes: a first row of at least one rung, wherein an electrically conductive winding is wound around each rung of the at least one rung, forming a first row of electrical windings along a first direction; a second row of at least one rung, wherein an electrically conductive winding is wound around each rung of the at least one rung, forming a second row of electrical windings along the first direction; and a middle rail having a width along a second direction normal to the first direction, separating the first and the second row of electrical windings.
H02M 3/158 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
Disclosed is a method for forming selenoneine or analogs thereof. The method may include phosphorylating sodium selenide to a selenophosphate, using adenosine triphosphate (ATP) and at least a first protein, generating a selenosugar by converting the selenophosphate using at least a second protein in the presence of a common sugar donor, and forming selenoneine or an analog thereof by combining the selenosugar with N,N,N-trimethyl-L-histidine or analogs thereof using at least a third protein. The method may include combining SenA, SenB, and SenC in an aqueous buffer at neutral pH and ambient temperature, and allowing SenA, SenB, and SenC to form selenoneine or an analog thereof in the presence of ATP, a common sugar donor, and sodium selenide.
The Board of Regents of The University of Texas System (USA)
Inventor
Troyanskaya, Olga G.
Chen, Kathleen
Zhou, Jian
Abstract
Processes that determine transcriptional regulation from genetic sequence data are described. Generally, computational models are trained to predict transcriptional regulatory effects, which can be used in several downstream applications. Various methods further develop research tools, develop and perform diagnostics, and treat individuals based on identified variants.
San Diego State University Research Foundation (USA)
Inventor
Kleiner, Ralph
Wang, Danyang
Purse, Byron
Shalamberidze, Ana
Abstract
Disclosed is a platform for fluorescence imaging of bulk RNA dynamics in living cells. The platform utilizes a technique including exposing a plurality of live cells configured to overexpress a WT or mutant ribonucleoside kinase UCK2 under control of an inducible promoter, a constitutively active promoter, or both, to a first quantity of a fluorescent nucleoside (such as fluorescent bicyclic and tricyclic cytidine analogues) for a first period of time.
Antenna arrays, systems and methods using an algorithm-based array synthesis approach of designing and manufacturing an antenna array with non-uniform element distribution which fundamentally enables low side lobe beamforming capability over desired broadband/multiband frequency range across large scanning angles.
H01Q 5/20 - Arrangements for simultaneous operation of antennas on two or more different wavebands, e.g. dual-band or multi-band arrangements characterised by the operating wavebands
H01Q 3/38 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the relative phase or relative amplitude of energisation between two or more active radiating elementsArrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase by electrical means with variable phase-shifters the phase-shifters being digital
H01Q 9/28 - Conical, cylindrical, cage, strip, gauze or like elements having an extended radiating surface Elements comprising two conical surfaces having collinear axes and adjacent apices and fed by two-conductor transmission lines
9.
METHODS, DEVICES AND COMPOSITIONS FOR PRESERVING HUMAN MILK
Described herein, are compositions and methods for preserving human milk, preventing rancidity of human milk, extending shelf life of human milk, and maintaining the nutritional properties of human milk. Specifically, the present disclosure provides, among other things, devices for storing preserved human milk and methods and compositions for preserving the same.
A processing unit leverages a decode stage's pool of instructions, thereby expanding available instruction choices and eliminating the need for expensive OoO techniques to identify reordering opportunities. The processing unit introduces instruction reordering by presenting an alternative instruction to the warp scheduler through the existing interface rather than offering the oldest instruction in each warp. The result is a simple and efficient OoO engine that operates predominantly in the processing unit's front end.
Disclosed are techniques for training a graph language model (GEM). The techniques generally include training the GEM on a training corpus, expanding a current training knowledge graph into an expanded knowledge graph by distilling semantic information from the training corpus using neural inversion. The knowledge graph is only expanded when there is new data, and if convergence has not been reached, the method may include updating the training corpus by injecting the expanded knowledge graph into the training corpus, thereby making the expanded knowledge graph the current training knowledge graph. The training, expanding, and updating steps are repeated until convergence. The training corpus may be formed by parsing a dataset into chain graphs, where syntactic language information is represented as a chain sequence of one or more root nodes, and where semantic information from the seed knowledge graph is added as leaf nodes around each root node.
A method for quantum error correction includes: trapping and/or manipulating an array of qubits that include encoded neutral atoms or ions and forms a computational space; encoding the array of qubits to a state characterized in that an error during at least one of an idling, gate, or other operation results in a respective qubit transition to a disjointed state where that error can be detected without disturbing the qubits remaining in the computational space; performing a syndrome measurement of a quantum error correcting code; identifying the presence and location of an error by detecting the corresponding neutral atom or ion has left the computational space after performing the operation; identifying a logical error in the quantum error correcting code associated with a loss of qubit information based on the identified error location and results of the syndrome measurement; and adjusting subsequent computational steps based on the identified logical error.
Mosquito attractant compositions that mimic the neural activity evoked by real human odor in the mosquito brain. The attractant compositions comprise 1-hexanol and linear long chain aldehydes that mimic human attractant odors and that differentiate humans from other animals. Methods for controlling malaria and dengue virus transmission as well as other diseases that are transmitted using mosquitos as vectors are included as are general methods and devices for attracting, killing, and controlling populations of mosquitos.
A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
A01N 35/02 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio-analogues thereofDerivatives thereof, e.g. acetals
Use of high frequency waves, such a millimeter waves, in many circumstances is prevented due to their inability to diffract around common obstacles. Disclosed herein is a system and method for transforming an incident high frequency wave. The system includes meta-atom pairs that define a surface. The meta-atom pairs generate an electro-magnetic response by interacting with an incident wave. This electro-magnetic response can be modulated by applying voltage to the meta-atom pairs. The electro-magnetic response transforms the incident wave into an emitted wave based on its controlled properties. The system and method are able to, by changing the voltage applied, steer the emitted wave a full 360 degrees as wells as transmit it through the surface without significant power loss. Embodiments enable the transmission through or around many obstacles that would normally interfere with high frequency waves.
Systems and methods for batch correcting single-cell abundance data obtain a measurement value of each feature in a plurality of features originating from each cell in a plurality of cells. The cells collectively originate from a plurality of samples. Feature measurements for each cell are used to cluster the cells into clusters. Cluster assignments of each cell and an identity of a sample in the plurality of samples from which each cell originated are used to compute sample-level local inverse Simpson index (LISI) scores penalized by a measure of importance of cells in each sample. Scores are scaled and ordered before application of a Dixon's Q-test groups them into one or more groups. For each respective group, a common batch assignment is applied to each of the samples in the respective group.
Disclosed is a technique for improving the throughput of a neural network, using multiplexing and demultiplexing of information. Specifically, the multiplexing may include receiving a plurality of inputs, generating transformed inputs by performing, via a multiplexing layer, a transformation to each input of the plurality of inputs, and combining the transformed inputs into a single compact representation of the plurality of inputs. The demultiplexing may include receiving an output from a neural network, generating a plurality of values by converting, via a demultiplexing layer, the output back into independent representations, and producing predictions for each input based on the plurality of values. Further improvements may be seen when pretraining of the neural network and/or high-throughput transformers are incorporated.
A flat nanophotonic computational camera, which employs an array of skewed lenslets (meta-optics) and a learned reconstruction approach is disclosed herein. The optical array is embedded on a metasurface that with a height of approximately one micron, is flat and sits on the sensor cover glass at approximately 2.5 mm focal distance from the sensor. A differentiable optimization method continuously samples over the visible spectrum and factorizes the optical modulation for different incident fields into individual lenses. A megapizel image is reconstructed from a flat imager with a learned probabilistic reconstruction method that employs a generative diffusion model to sample an implicit prior. A method for acquiring paired captured training data in varying illumination conditions is proposed. The proposed flat camera design is assessed in simulation and with an experimental prototype, validating that the method is capable of recovering images from diverse scenes in broadband with a single nanophotonic layer.
Disclosed is a method for quantitative detection of a small, aberrant viral nucleic acid. The method includes combining a detection mixture with a sample, and allowing a reaction with the test mixture to begin. The sample includes an RNA sample. The detection mixture includes a Cas13 enzyme, a reporter, a sequence-specific CRISPR RNA (crRNA), and a buffer. The method includes determining a quantitative value representative of the reporter in the test mixture, where the quantitative value is a measure of an amount of target RNA present in the RNA sample.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
The present disclosure provides a rapid, facile, economical, and highly scalable method for producing selenoneine. The method involves SenA, hercynine, a selenosugar, and optionally a reductant, and a single, high-yielding enzymatic step in, e.g, aneutral-pH aqueous buffer and at ambient temperature. It can achieve yields of around 5 grams selenoneine per liter reaction with approximate costs of $100 per gram selenoneine.
Disclosed herein are compounds of Structural Formula I. Compounds of Structural Formula I inhibit aldehyde dehydrogenase isoform 1a3 (ALDH1a3) and are useful for treating cancer, for example, metastatic or chemoresistant cancer, such as metastatic cancer resistant to chemotherapy. Also disclosed herein are compositions comprising compounds of Structural Formula I and uses of compounds of Structural Formula I for treating cancer, for example, metastatic or chemoresistant cancer.
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
21.
HIGH-THROUGHPUT METHODS TO IDENTIFY AND CLASSIFY MODULATORS OF NUCLEOLAR MORPHOLOGY AND FUNCTION
Disclosed is a method coupling automated microscopy imaging with a deep neural network and computational modeling to classify distinct drug-induced nucleolar morphology changes with high accuracy and link them to nucleolar dysfunction. As such, this method can enable high-throughput characterization of nucleolar and other condensate phase behavior changes in chemical or genetic screens, directly linking condensate morphology changes to its physical mechanism of action for the first time.
A system for determining the ripeness of a food product (such as a fruit or vegetable) may include a metamaterials-based sticker configured to be coupled to an outer surface of the food product. The sticker may include micron-scale metal resonators coupled to a base, and may be configured to resonate at a sub-terahertz (THz) frequency. The system may include a handheld device, which may include a receiver configured to receive a reflection spectrum from the sticker after the sticker has been excited by electromagnetic radiation. The receiver may be configured to detect one or more wavelengths having frequencies of around 100 GHz - 170 GHz and 210 - 250 GHz. The system may include processing unit(s) configured to, collectively, perform various steps, including determining a resonant frequency, a dielectric property, a refractive index, or a value representative of the ripeness of the food product based on a reflection spectra.
Disclosed is a method for characterizing compositional and functional histories of cellular proteins and their associated molecular complexes in space and time. The method may include forming fusion proteins by fusing a universal genetic tag to each of a plurality of endogenous proteins. The fusion proteins may be conditionally labelled with a first ligand. The first ligand may be a ligand with a developed immunopurification capability and a known imaging capability. The method may include expressing the fusion proteins and performing at least one analysis. The analyses may include (i) tracking the plurality of endogenous proteins and any associated macromolecular complexes; (ii) determining composition and function of the plurality of endogenous proteins and/or any associated macromolecular complexes; and/or (iii) removing a ligand and performing a pulse-chase analysis.
A design methodology and tool called INFORM are provided that use a two-phase approach for sample-efficient constrained multi-objective optimization of real-world nonlinear systems. In the first optional phase, one may modify a genetic algorithm (GA) to make the design process sample-efficient, and may inject candidate solutions into the GA population using inverse design methods. The inverse design techniques may be based on (i) a neural network verifier, (ii) a neural network, and (iii) a Gaussian mixture model. The candidate solutions for the next generation are thus a mix of those generated using crossover/mutation and solutions generated using inverse design. At the end of the first phase, one obtains a set of nondominated solutions. In the second phase, one chooses one or more solution(s) from the non-dominated solutions or another reference solution to further improve the objective function values using inverse design methods.
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
G06F 111/06 - Multi-objective optimisation, e.g. Pareto optimisation using simulated annealing [SA], ant colony algorithms or genetic algorithms [GA]
25.
ENHANCED NUCLEIC ACID DETECTION USING CAS13 AND DESIGNED SECONDARY STRUCTURE
Disclosed are techniques for enhanced nucleic acid detection using blocked or partially blocked crRNAs or target RNAs, and a composition of matter (detection reactions consisting of occluded crRNAs or target RNAs). Here, the mechanism of Cas 13 protein activation in response to RNA structure perturbations was systematically probed using a massively multiplexed screen. It was found that there are two distinct sequence-independent modes by which secondary structure affects Cas13 activity: structure in the protospacer region competes with the crRNA and can be disrupted via a strand-displacement mechanism, while structure in the region 3′ to the protospacer has an allosteric inhibitory effect. The kinetic nature of the strand displacement process was leveraged to improve Cas13-based RNA detection and enhance mismatch discrimination by up to 50-fold, enabling sequence-agnostic mutation identification at low (<1%) allele frequencies.
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
C12Q 1/683 - Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
C12Q 1/6832 - Enhancement of hybridisation reaction
41 - Education, entertainment, sporting and cultural services
Goods & Services
Association services, namely, promoting the interests of alumni; arranging, organizing, conducting, and hosting alumni events for business development, business networking, and professional networking purposes; promoting special events of university and alumni groups; charitable services, namely, organizing and conducting volunteer programs and community service projects; administration of a program for alumni to interview university applicants Arranging, organizing, conducting and hosting social entertainment events; organizing and arranging of seminars, discussions, and lectures in the fields of general interest, education, music, art, science, literature, government, social justice, leadership development, sports, and academics; educational services, namely, providing educational speakers and lecturers; providing an interactive website featuring information related to educational, entertainment, athletic and social events for alumni of an educational institution; providing online newsletters featuring articles and information regarding alumni news, alumni achievement, career opportunities, and networking events
A process for making liquid fuels, especially diesel fuel, from primary alcohols. The process involves subjecting a feedstock comprising primary alcohols to Guerbet coupling to yield a first intermediate mix; subjecting the first intermediate mix to hydrogenolysis to yield a second intermediate mix; and subjecting the second intermediate mix to etherification to yield a liquid fuel suitable for use in internal combustion engines.
F02D 19/06 - Controlling engines characterised by their use of non-liquid fuels, pluralities of fuels, or non-fuel substances added to the combustible mixtures peculiar to engines working with pluralities of fuels, e.g. alternatively with light and heavy fuel oil, other than engines indifferent to the fuel consumed
29.
METHOD FOR CONVERTING FARNESYL PYROPHOSPHATE SYNTHASE INTO A GERANYL PYROPHOSPHATE SYNTHASE
Disclosed are techniques for monoterpenes biosynthesis in engineered microorganisms having a mevalonate pathway, where the microorganisms express an engineered enzyme. The engineered enzyme may include one or more peptides that are selected to alter the active site pocket volume of the engineered enzyme as compared to a wild-type farnesyl pyrophosphate synthase. The engineered enzyme may include a first peptide (such as a linker peptide) fused to a C-terminus of a farnesyl pyrophosphate synthase. Optionally, a second peptide (such as a Myc-tag or a HA-tag) be fused to the first peptide. The method may include exposing the engineered microorganism to a carbon source (such a glucose). The method may include allowing the engineered microorganism to generate (i) a first product from the mevalonate pathway and (ii) the engineered enzyme. The method may include forming a monoterpene by allowing the first product and the engineered enzyme to interact.
Disclosed are a method and system for thermal stabilization of pharmaceutical formulations containing proteins and monoclonal antibodies. The disclosed method of Rapid Room Temperature Aerosol Dehydration (RTAD) provides a scalable system for continuous dehydration of liquid pharmaceutical and biopharmaceutical formulations that provides thermal stabilization of biological drugs by converting liquid drugs into powder form, enabling their transportation, storage and handling at room temperature. The disclosed process can generate sprays/aerosols with droplets that are lOOx smaller (0.2-20 pm ) than existing spray drying technologies and perform dehydration without applying heat, which mitigates the risk of damage of thermolabile biologicals and provides a significant reduction in energy requirements. The technology has demonstrated superiority of tire system over traditional spray drying and freeze drying with respect to energy consumption, biological activity, scalability, powder dissolution, reduced protein aggregation, particle size and size uniformity, and high- quality of produced inhalable and reconstitutable biologic formulations.
B05B 7/24 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
B05B 9/04 - Spraying apparatus for discharge of liquid or other fluent material without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible containerSpraying apparatus for discharge of liquid or other fluent material without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pump
F26B 3/12 - Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray
B05B 7/16 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating the material to be sprayed
B01D 1/18 - Evaporating by spraying to obtain dry solids
F26B 21/00 - Arrangements for supplying or controlling air or gases for drying solid materials or objects
A process for making liquid fuels, especially diesel fuel, from primary alcohols. The process involves subjecting a feedstock comprising primary alcohols to Guerbet coupling to yield a first intermediate mix; subjecting the first intermediate mix to hydrogenolysis to yield a second intermediate mix; and subjecting the second intermediate mix to etherification to yield a liquid fuel suitable for use in internal combustion engines.
C10L 1/02 - Liquid carbonaceous fuels essentially based on components consisting of carbon, hydrogen, and oxygen only
C07C 2/06 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation of alkenes, i.e. acyclic hydrocarbons having only one carbon-to-carbon double bond
C07C 37/16 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving hydroxy groups of phenols or alcohols or the ether or mineral ester group derived therefrom
C07C 41/09 - Preparation of ethers by dehydration of compounds containing hydroxy groups
Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.
A synthetic triterpene composition such as squalene and methods for producing the composition by novel chemical synthesis routes is claimed. The squalene produced by the synthetic methods covered in this invention formulation is of high purity suitable for use in making vaccine adjuvants, antioxidant formulations, and drug delivery agents.
Systems and methods for predicting cell-type-specific gene expression from genetic sequence are described. A computational framework can comprise a computational model for predicting epigenetic regulatory markers using genetic sequence as input. A computational framework can additionally, or alternatively, comprise a computational model for predicting cell-type-specific gene expression utilizing epigenetic regulatory markers spaced along sequence of genes. The computational model for predicting cell-type-specific gene expression can be trained with single-cell genetic expression profiles, such as scRNA-seq or snRNA-seq. The computational framework can be utilized to assess polymorphic sequences, such as polymorphisms related to medical disorders. Various methods further develop research tools, perform diagnostics, and treat individuals based on cell-type-specific gene expression levels, which can be further based on differential gene expression patterns among polymorphic sequences.
Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches.
A magnetic orbital angular momentum beam accelerator will accelerate charged particles, electrons or ions, from rest in zero or low magnetic field into a high magnetic field regions with high kinetic energies in the form of magnetic orbital angular momentum. For example, a beam injector that accelerates electrons or ions into 1T magnetic fields with tens of keV kinetic energies transverse to the magnetic fields can be used to heat magnetically confined plasmas, to inject an initial energetic plasma component with high magnetic orbital angular momentum and to produce highly transverse particle momenta to the magnetic field for electron or ion beam lithography.
According to various embodiments, a machine-learning based system for mental health disorder identification and monitoring is disclosed. The system includes one or more processors configured to interact with a plurality of wearable medical sensors (WMSs). The processors are configured to receive physiological data from the WMSs. The processors are further configured to train at least one neural network based on raw physiological data augmented with synthetic data and subjected to a grow-and-prune paradigm to generate at least one mental health disorder inference model. The processors are also configured to output a mental health disorder-based decision by inputting the received physiological data into the generated mental health disorder inference model.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
Compositions of matter and methods for using the composition of matter may be provided. The method may include providing a virus-like particle (VLP) comprising C. elegans retrotransposon 1 (Cer1) and a heterologous RNA-based agent to an organism and allowing the organism to transfer the heterologous RNA-based agent to a tissue within the organism.
Cas-cleavable reporter systems, CRISPR-Cas systems thereof, and methods of use thereof in CRISPR-Cas based diagnostics. Cas-cleavable reporter systems may generate a luminescent, fluorescent, or other detectable signal upon Cas-collateral cleavage of one or more reporter system components. CRISPR-Cas systems may comprise a Cas protein having collateral cleavage activity, guide molecules, and the Cas-cleavable reporter system. Cas-cleavable reporter systems may be a split luciferase reporter system, at least one element of which is bound to beads. For multiplexing, CRISPR-Cas systems may comprise a Cas-cleavable quenched reporter system, optionally a Cas-cleavable quenched fluorescent reporter system, a Cas protein having collateral cleavage activity, and target-specific guide molecules attached to color-coded beads. CRISPR-Cas systems may further comprise amplification reagents. Methods may apply said CRISPR-Cas systems to flow cell, well-plate, or other devices, and may measure detectable signals by microscopic, plate reader, or other methods.
Disclosed is a technique that enables structural reinforcement and thermal stabilization of the conductor winding in a superconducting coil configuration, and superconducting coils produced via the technique. The superconducting coils generally include coil windings of superconducting materials defining an electrically conductive channel having an inlet and an outlet, where the coil windings are either (i) helically wound around a curve around a central axis or (b) wound in helical layers around a curve around a central axis. One or more of the coil windings are operably coupled to at least one co-wound reinforcement layer, where the at co-wound reinforcement layer(s) are positioned between at least two adjacent superconducting coil windings or layers of superconducting coil windings. The method can significantly improve the packing factor in a coil winding while simplifying quench protection, permitting the construction of all-metal high field magnets with large bore and high magnetic field.
H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
G01R 33/3815 - Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using electromagnets with superconducting coils, e.g. power supply therefor
H01F 6/02 - QuenchingProtection arrangements during quenching
H01F 41/04 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets for manufacturing coils
41.
OPTOGENETIC CIRCUITS FOR CONTROLLING CHEMICAL AND PROTEIN PRODUCTION IN ESCHERICHIA COLI
Disclosed herein are optogenetic circuits for the bacterium Escherichia coli that induce gene expression in darkness and repress it under blue light. Applying them to metabolic engineering improves chemical production compared to chemically induced controls in light-controlled fermentations. More particularly, these circuits can be used to control protein production with light. The system and method use light as a suitable alternative to chemical induction for microbial production of chemicals and proteins.
Disclosed are methods and a pharmaceutical composition for the prevention and treatment of fibrosis by the inhibition of fibronectin matrix assembly, as well as insights into the molecular mechanism by which cell-mediated assembly of fibronectin (FN) matrix contributes to extracellular matrix (ECM) accumulation. Peptides S2, S3, S20, and variants thereof may be utilized, either alone or fused to one or more proteins. In one aspect, a construct comprising a first protein fused to a first end of a peptide and a second protein fused to a second end of the peptide may be used, where the peptide has at least 80% sequence identity to S2, S3, or S20. The peptide may then be allowed to interact with fibronectin.
in situin situ position detection, thickness and refractive index measurement, and/or focus control, are provided. The systems may include a first laser emitting device, a first lens, a first beam splitter and a second lens respectively forming an optical path. The second lens, the first beam splitter, a third lens, and an image detection and processing module (that includes a sensor, such as a photodiode) may form an optical return path. The second lens may be configured to continuously oscillate, as a function of time, a focal position of a laser from the first laser emitting device. The image detection and processing module may be configured to receive a reflected beam, send information related to the received beam to processing units(s), which may be configured to receive the information and determine one or more surface positions based on a temporal response of the information.
Methods for co-designing transformer-accelerator pairs are provided. The methods may include using a transformer embedding to generate a computational graph and a transformer model. The methods may include running the computational graph through a surrogate model and outputting accuracy data of the surrogate model. The methods may include using an accelerator embedding and the transformer model to simulate training and inference tasks and outputting hardware performance data of the transformer model. The methods may include sending the hardware performance data (such as latency, energy leakage, dynamic energy, and chip area, which may be optimizable performance parameters) and model accuracy data to a co-design optimizer. The methods may include generating an output transformer-accelerator or a transformer-edge-device pair from the co-design optimizer. The transformer model and accelerator embedding may be the output transformer-accelerator or a transformer-edge-device pair.
Block copolymer-stabilized nanoparticles (50 nm - 1000 nm in size) of oligonucleotides with a polyethylene glycol (PEG) steric stabilizing layer are provided. Such nanoparticles may be formed using stabilizing blocks of PEG with molecular weights of 1000-5000 Dalton molecular weight, and hydrophobic anchoring blocks of a degradable polylactide and/or degradable lactide-co-glycolide polymer with molecular weights of 1000-20,000 Dalton molecular weight. The anchoring blocks may be, e.g., a polycaprolactone polymer, a polylactic acid polymer, and/or a copolymer of a lactide-co-glycolide polymer. Such nanoparticles are preferably configured to be internalized into cells and transfect cells at least as effectively as a lipid nanoparticle formulated with 1500 Dalton molecular weight PEG and Dimyristoyl glycerol (DMG) anchoring lipids.
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
Disclosed is a method to 3D print materials with defined bacterial communities into controlled, complex 3D structures, and compositions. The technique includes first providing an ink composition that includes a pre-polymer composition and a microorganism, where the pre-polymer composition includes a polymerizable monomer, a cross-linking agent, the photoinitiator, and a solvent. The technique also includes 3D printing a pattern in a hydrogel support matrix using the ink composition where the hydrogel support matrix is in a container. The technique may also include forming a 3D printed engineered living material by curing the 3D printed pattern.
Provided are polynucleotides comprising a transcriptional control element comprising a promoter sequence having at least 80% sequence identity to SEQ ID NO: 1. SEQ ID NO:2. SEQ ID NO:3 or SEQ ID NO:4 and a cell- or tissue-specific enhancer element. Also provided are compositions (e.g., vectors, viruses, host cells, and pharmaceutical compositions) comprising said polynucleotides, methods that are useful for expressing a target gene in a host cell, and methods that are useful for expressing a target gene in a subject in need thereof.
Systems and methods for fibrous material manufacturing are provided. The methods include dispensing a first stream of a solution (that includes a crosslinkable material) from first nozzle(s) into a bath containing a liquid (that includes a first material). The first nozzle(s) are submerged in the liquid. The methods include dispensing a second stream from second nozzle(s) also submerged in the liquid. The second stream(s) are configured to elongate and thin the first stream(s). The second stream contain a liquid. The liquid includes a second material, which may be the same, or may be different, form the first material. The methods include forming a fibrous material by crosslinking the crosslinkable material in the first stream (e.g., using a light source to cross-link a photo-crosslinkable material in the stream).
D01F 1/08 - Addition of substances to the spinning solution or to the melt for forming hollow filaments
D01F 6/36 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from copolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds comprising unsaturated carboxylic acids or unsaturated organic esters as the major constituent
49.
THREOGLUCINS AS POTENT-ANTIBACTERIAL AGENTS AGAINST STREPTOCOCCUS SUIS
Compositions are provided that can be used to, e.g., treat or prevent infections caused by Streptococcus suis. The compositions may include one or more threoglucins in a carrier, at a total concentration of threoglucins being at least 1 μM. The at least one threoglucin may include one or more of threoglucins A-R. Such threoglucins may be produced by, e.g., growing a culture of Streptococcus suis in the presence of niacin, nicotinamide, and/or anabasine.
Disclosed herein are methods and devices for generating sprays with droplets of micron and submicron diameter. This is accomplished through the disintegration of a thin liquid film using an atomizing gas flow. The device comprises a nozzle device having at least three channels comprising an inner channel, at least one middle annular channel, outside of the inner channel, and at least one outer annular channel outside of the at least one middle annular channel, the at least one middle annular channel being coaxially arranged between the inner channel and the at least one outer annular channel and having a gap width sufficient so as to atomize a liquid flowing through the at least one middle annular channel upon flow of one or more gases through at least the inner channel and the at least one outer annular channel. The methods comprise use of the device for generating atomized particles.
The present disclosure relates to prime editing systems, compositions, and methods for altering target gene sequences and/or expression of target gene sequences.
Described herein is a method of screening for a nuclease with an altered nuclease activity comprising; a) forming a first compartmentalizing reaction comprising a carrier and a variant nuclease template nucleic acid comprising a coding region for a variant nuclease, and amplifying said coding region for said variant nuclease, to obtain variant nuclease encoding nucleic acid; b) forming a second compartmentalizing reaction comprising said variant nuclease encoding nucleic acid, and performing an in vitro transcription and translation reaction to obtain variant nuclease polypeptides; and c) forming a third compartmentalizing reaction comprising said variant nuclease polypeptides, and assaying said variant nuclease polypeptides for the altered nuclease activity of said nuclease.
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
53.
PATH-INTEGRATED OPTICAL SENSING AND SIMULTANEOUS RETROREFLECTOR TRACKING
A retroreflector tracking and sensing technique is provided. Systems may include a laser source, optical component(s), and a beam steering component disposed along an optical transmit path. The optical component(s) may be disposed between the laser source and the beam steering component (such as a mirror coupled to an actuator). The systems may include a position-sensitive detector (PSD). The beam steering component, one or more of the optical component(s), and the PSD may be disposed along an optical return path. The optical component(s) in the optical return path may be disposed between the beam steering component and the position-sensitive detector. The PSD may be operably coupled to a position tracking analyzer and an optical sensing analyzer. Electrical signals generated by the PSD may be configured to be used for retroreflector tracking and/or optical sensing.
G01S 17/66 - Tracking systems using electromagnetic waves other than radio waves
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01S 7/481 - Constructional features, e.g. arrangements of optical elements
54.
SYSTEMS AND METHODS FOR SPATIO-TEMPORAL ANALYTE MEASUREMENTS OVER A FIELD USING AN OPTICAL WEB
Systems and methods are provided for measuring analytes (e.g., greenhouse gases, such as nitrous oxide) in the air over a field or other area. An optical web can be cast over the field, using a laser respectively provided from each of two or more towers disposed around an edge of the field, for the estimation of flux emissions and their spatiotemporal parameters. Each laser can be configured to provide light at a respective predetermined wavelength to one or more reflectors disposed around an edge of the field, providing a path integrated measurement, and then the light returns from the reflector to a detector that is coaligned with each respective laser. By making many such measurements, a set of linear equations can be generated, which can then be used to solve for the emission in any one grid cell of the field.
G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01W 1/02 - Instruments for indicating weather conditions by measuring two or more variables, e.g. humidity, pressure, temperature, cloud cover or wind speed
55.
OPTICAL MATERIALS FOR SPECTRALLY SELECTIVE HEAT TRANSFER
Techniques for controlling heat transfer or emission using spectrally selective transmissive substrates are provided. Each spectrally selective transmissive substrate may include a plurality of alternating stacked layers, where the spectrally selective transmissive substrate is generally at least 50% transparent on average across a long wavelength infrared wavelength range (8 pm to 13 pm), and greater than 30% reflective on average across infrared wavelengths outside the long wavelength infrared (LWIR) wavelength range. Such substrates may include polymer such as a polyolefin, a nylon, or a polytetrafluoroethylene (PTFE), and may include air voids with a lower refractive index than polyethylene, and/or particles with a higher refractive index than polyethylene, such as ZnO. ZnS. ZnSe, CuO, FeO, Si, etc. Particles sizes are typically selected to behave as an effective medium in LWIR wavelengths, which are 5-20x larger than the particles, while still providing either solar scattering or solar transparency as desired.
F28F 13/18 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by applying coatings, e.g. radiation-absorbing, radiation-reflectingArrangements for modifying heat transfer, e.g. increasing, decreasing by surface treatment, e.g. polishing
E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshineSimilar screens for privacy or appearance
B32B 17/10 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like comprising glass as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
E04B 1/76 - Heat, sound or noise insulation, absorption, or reflectionOther building methods affording favourable thermal or acoustical conditions, e.g. accumulating of heat within walls specifically with respect to heat only
56.
IN-VIVO PROXIMITY-BASED LABELING SYSTEMS AND APPLICATIONS THEREOF
In one aspect, compositions and methods are described herein for providing a microenvironment mapping platform operable to selectively identify various features, including in vivo protein-protein interactions on cellular membranes. In some embodiments, a composition comprises a tetrapyrrole photocatalyst, and a protein labeling agent, wherein the tetrapyrrole photocatalyst has electronic structure to activate the protein labeling agent to a reactive intermediate via energy transfer. The reactive intermediate reacts or crosslinks with a protein or other biomolecule within the diffusion radius of the reactive intermediate.
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood groups or blood types
57.
SYSTEM AND METHOD FOR GENERATING SYNTHETIC COUNTERFACTUALS VIA SPATIOTEMPORAL TRANSFORMERS
Disclosed is a framework called SCouT that employs a Transformer architecture to make counterfactual predictions that can be used in healthcare and other longitudinal decision-making scenarios. The disclosed approach can use longitudinal donors under an intervention to estimate the synthetic counterfactual for other units. The Transformer-based encoder-decoder model uses a causal map, which enables spatial bidirectionality, to autoregressively generate a synthetic control of a target unit.
A process for water, mineral, and/or organics recovery, as well as devices and systems that practice the process, are disclosed. The process may include providing a plurality of evaporator structures, each structure physically separated from the others, and contacting the first end of each evaporator structure with a liquid containing a plurality of materials (such as a solvent and one or more minerals). The process may include allowing capillary forces and siphonic action to draw at least one material of the plurality of materials (which may be, e.g., the solvent, a volatile organic material, and/or a mineral) from the first end towards the second end, and evaporating one or more of the plurality of materials by transferring at least one form of environmental energy (such as solar energy, wind energy, and/or ambient heat of air) directly to each evaporator structure, thereby providing the latent heat of vaporization.
Systems and methods for tackling a significant problem in data analytics: inaccurate dataset labeling. Such inaccuracies can compromise machine learning model performance. To counter this, label error detection algorithm is provided that efficiently identifies and removes samples with corrupted labels. The provided framework (CTRL) detects label errors in two steps based on the observation that models learn clean and noisy labels in different ways. First, one trains a neural network using the noisy training dataset and obtains the loss curve for each sample. Then, one applies clustering algorithms to the training losses to group samples into two categories: cleanly-labeled and noisily-labeled. After label error detection, one removes samples with noisy labels and retrains the model.
A light emitting device comprises a waveguide, a downconverting thin-film stack in optical communication with the waveguide, and an OLED thin-film stack in optical communication with the downconverting thin-film stack. An integrated photonic system comprises the downconverted as described above, wherein the downconverted OLED stack is integrated with a silicon photonic chip or CMOS photonic chip. A method for providing pump light for a silicon photonic integrated circuit comprises providing the integrated photonic as described above, producing light via the OLED thin-film stack; downconverting the produced light via the downconverting thin-film stack, and guiding the downconverted light via the waveguide.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A reactant comprising one or more polymers can be subjected to multiple consecutive processing cycles. Each processing cycle can have a first period with heating applied and a second period immediately following the first period with no heating applied. A duration of each processing cycle can be less than or equal to 10 seconds, and a duration of each first period can be less than 1 second. The subjecting can be effective to convert at least some of the reactant into one or more products, for example, one or more constituent monomers or other volatile or gas-phase species. In some embodiments, a reactor can be provided between a heating source and the reactant, for example, to provide a spatio-temporal temperature profile for improved polymer processing.
C08J 11/12 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by dry-heat treatment only
A base station classifier on a portable device includes code for obtaining base station resource allocations, converting the allocations into vectors to provide input to a neural network, and providing access to a trained neural network that evaluates the vectors to identify that a base station is a trusted vendor base station. A method of operations listens to resource allocations of a connected device, converts each allocation into a vector suitable for neural network analysis, evaluates the vector with a trained neural network with to determine if the vector is from a trusted base station, and connects only to base stations indicated by the trained neural network to be a trusted base station.
H04L 41/16 - Arrangements for maintenance, administration or management of data switching networks, e.g. of packet switching networks using machine learning or artificial intelligence
Provided herein are methods of using small molecule inhibitors of the MTDH-SND1 protein-protein interaction, such as a compound of the following structural formula: (I) or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X1, X2, X3, X4, X5, X6, X7, R3, R4, m) are as described herein. The compounds described herein can be used, for example, to treat cancer as, for example, by inhibiting metastasis of a cancer, sensitizing a cancer to treatment with an additional therapy, and/or promoting T-cell activation and/or infiltration in response to a cancer.
Provided herein are methods of using small molecule inhibitors of the MTDH-SND1 protein-protein interaction, such as a compound of the following structural formula: (I) or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X1, X2, X3, X4, X5, X6, X7, R3, R4, m) are as described herein. The compounds described herein can be used, for example, to treat cancer as, for example, by inhibiting metastasis of a cancer, sensitizing a cancer to treatment with an additional therapy, and/or promoting T-cell activation and/or infiltration in response to a cancer.
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Disclosed is DNA valency sorting chromatography, a purification method for separating solutes based on the number of barcoded DNA molecules present on their surface, which can operate using conventional low-pressure chromatography equipment and instrumentation. Solutes can take a variety of forms, including biological macromolecules, polymeric nanoparticles, gold or silver nanospheres, gold nanorods, iron oxide nanoparticles, and semiconducting nanocrystals. In contrast to most existing purification procedures, DNA valency sorting is highly selective for the DNA sequence specifically, rather than the characteristics of the solute as a whole, and uses extremely gentle elution conditions. As a result, it is applicable to a range of solute characteristics, including variable chemical composition, surface charge, and materials with hydrodynamic diameters up to 80 nm, which cannot be purified with a well-defined number of macromolecules by any other existing technique.
In one aspect, methods for the facile synthesis of cationic cobalt complexes for asymmetric hydrogenation of alkenes are provided. Synthetic methods described herein, in some embodiments, provide Co(I) precatalysts on a time scale and yield permitting catalytic evaluation of a significant number of enantiopure ligands.
The present disclosure provides methods for defining a magnet array for a stellarator. In some embodiments, the magnet array, once defined, comprises a plurality of permanent magnets, where each permanent magnet of the plurality of permanent magnets is selected from a set of predetermined permanent magnet types. In some embodiments, each predetermined permanent magnet type in the set of predetermined permanent magnet types has a predetermined shape (geometry) and/or predetermined orientation angles (also known as a polarization orientation).
Systems and methods are provided trajectory prediction that leverages game-theory to improve coverage of multi-modal predictions. Examples of the systems and methods include obtaining training data including first trajectories for a first plurality of agent devices and first map information of a first environment for a past time horizon and applying the training data to a game-theoretic mode-finding algorithm to generate a mode-finding model for each agent device that predicts modes of the first trajectories. A trajectory prediction model can be trained on the predicted modes as a coverage loss term between predicted modes. Future trajectories can be predicted for a second plurality of agent devices based on applying observed data to the trajectory prediction model. A control signal can then be generated to effectuate an autonomous driving command on an agent device of the second plurality of agent devices based on the predicted future trajectories.
Devices and methods for forming a spheromak plasma with targeted properties are described. The targeted properties can include a kinetic energy, an ejection speed, a plasma current, a magnetic flux, and a magnetic helicity. Examples of a high flux spheromak gun can include numerous components based on location, function, dimension, and/or constituent material. The components can include an inner electrode, an outer electrode, an inner bias coil, an outer bias coil, a ferromagnetic-core, one or more gas-puff valves, a power supply, and an electronic controller programmed to implement a magnetic flux injection scheme. Systems, such as field-reversed configuration (FRC) systems, employing the devices and methods are also described.
Disclosed is a non-transitory computer-readable storage device containing instructions that, when executed by one or more processing units, causes the one or more processing units to deploy a multi -headed deep neural network (DNN) model that includes an exemplar-replay - style continuous learning (CL) algorithm. The DNN model may be configured to receive information originating from a wearable medical sensor and receive replay data from the CL algorithm. The CL algorithm may be configured with a data preservation module and a synthetic data generation module. The data preservation module may be configured to preserve a subset of training data from one or more previous missions based on an average training loss of each data instance. The synthetic data generation module may be configured to model a probability distribution of real training data and then generate synthetic data sufficient for replays while maintaining data privacy.
A highly reliable and accurate method of assessing bacterial community viability has been developed that allows for the assessment of extremely low biomass samples, which cannot be done with traditional methods, such as qPCR. The method utilizes both PMA and droplet digital PCR (PMA-ddPCR), resulting in very accurate quantification of DNA even at very low abundances. Comparing DNA abundance in untreated samples to DNA abundance in PMA-treated samples allows the calculation of the overall viability of bacteria in any given sample. Further, PMA can be combined with traditional RNA gene sequencing (using gene-specific primers for a target species or strain) to accurately profile, e.g., the human skin microbiome, which has previously been done using traditional sequencing methods alone, but this method allows for a species-level understanding of the viable (and nonviable) components of any complex bacterial community.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
The approach disclosed herein is a process for non-equilibrium chemical and materials processing using the combination of non-equilibrium plasma, non-equilibrium multi-functional catalysis, a precisely programed heating and quenching (PHQ), and supersonic reaction quenching to dynamically change the chemical equilibrium and increase the yield and selectivity of the products. An important feature of the disclosed approach is to realize an efficient and high selectivity synthesis method of chemicals and materials by using non-chemical equilibrium, non-equilibrium catalysts, and non-equilibrium of excited states via active control of molecule excitation by low temperature hybrid plasma, dynamics of chemical reactions by programed heating and supersonic quenching, and the design of non-equilibrium catalysts by thermal shocks and plasma coupling to enable distributed and electrified chemical synthesis of hydrogen, ammonia, valued carbon and other chemical products at atmospheric conditions. As such, the disclosed approach will enable distributed, electrified, low-carbon, and non-equilibrium chemical and material synthesis using renewable electricity, fossil fuels, biomass, and other abundant or waste resources.
Microbial consortia exert great influence over the physiology of humans, animals, plants, and ecosystems. However, difficulty in controlling their composition and population dynamics have limited their application in medicine, agriculture, biotechnology, and the environment. The approach disclosed herein provides an effective method to dynamically control population compositions in microbial consortia, which we demonstrate in the context of co-culture fermentations for chemical production. Co-culture fermentations can improve chemical production from complex biosynthetic pathways over monocultures by distributing enzymes across multiple strains, thereby reducing metabolic burden, overcoming endogenous regulatory mechanisms, or exploiting natural traits of different microbial species. However, stabilizing and optimizing microbial sub-populations for maximal chemical production remains a major obstacle in the field. An optogenetic circuit, called OptoTA, is disclosed for regulating a toxin-antitoxin system, which enables tunability of, e.g., Escherichia coli growth using only blue light. With the disclosed system, one can control population ratios of co-cultures of, e.g., E. coli and Saccharomyces cerevisiae containing different metabolic modules of biosynthetic pathways. Results reveal that intermediate light duty cycles improve chemical production by establishing optimal co-culture populations.
Embodiments are directed to a telemetry tool that can decode all of the control messages included in a signal. The tool uses the decoded control messages in conjunction with packet statistics and other information to derive knowledge regarding network capacity, including during carrier aggregation. The tool locates and decodes the control messages within a control channel and uses a set of validation methods to ensure the control messages are decoded correctly. The tool provides valuable information that can be used to improve network efficiency and function and allow user devices to take advantage of all of a network's available bandwidth.
Disclosed is a technique for reducing CO2 to oxalate utilizing a copper-free, nickel-enhanced electrocatalyst (such as a nickel-enhanced (Cr2O3)3(Ga2O3) electrocatalyst) that can be used for producing, e.g., 1-butanol, in exceedingly high yields. Disclosed herein are various synthetic methodologies for introducing nickel into the electrocatalysts, and described is the characterization, and optimization of the Ni enhanced electrocatalysts for the reduction of CO2 to 1-butanol with a maximum faradaic efficiency ξmax of 64%, at an overpotential of 900 mV (−1.48 V vs Ag/AgCl), and having an onset overpotential of 320 mV. The product selectivity is potential dependent with other C2+ products such as 3-hydroxybutanal, (ξmax 63%) at an overpotential of 890 mV (−1.4 V vs Ag/AgCl); acetic acid with ξmax 18% at an overpotential of 390 mV (−1.0 V vs Ag/AgCl); and acetone with ξmax 10% at an overpotential of 620 mV (−1.2 V).
C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
System and techniques for in-situ carbonation in a 3D printing process may be provided. The system may include a nozzle for in-situ carbonation in a 3D printing process (e.g., of a cement). The layer-3D-printing process with induced interfaces may include a device that enables layer-wise fabrication and enhanced carbonation. Additionally, the techniques may include a design of materials architecture (arrangement) by slicing them in cellular fashion that also enhances carbonation. Further, a printable wollastonite-based paste is disclosed.
C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures.
Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures.
C07C 51/363 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogenPreparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by substitution of halogen atoms by other halogen atoms
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
C07C 69/753 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
C07C 69/757 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
C07C 69/76 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
C07D 209/08 - IndolesHydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
C07D 209/48 - Iso-indolesHydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
C07D 209/88 - CarbazolesHydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
C07D 213/26 - Radicals substituted by halogen atoms or nitro radicals
C07D 403/08 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing alicyclic rings
Disclosed is a system and method for the controlled clustering of gene regulatory proteins at the specific target genomic loci. The technology enables formation of liquid-like droplets closely interfaced with genome organization. This technology can be utilized for perturbing endogenous nuclear structures as well as nucleating synthetic membrane-less assemblies. The technology can also be utilized for inducing or detecting mechanical stresses within the genome.
C12N 15/90 - Stable introduction of foreign DNA into chromosome
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
Disclosed is a structured light sensor system. The system may include a beam structuring module configured to receive a laser beam from a laser source and output structured light towards a target volume. The beam structuring module designed to receive a laser beam and output a structured laser beam may comprise a spatial light modulator or a combination of axicons, or spiral phase plates, or other optical elements. This module directs the structured beam towards various optical components, which may consist of single or multimode optical fibers or free-space optics, including lenses, collimators, and mirrors, to precisely shape and guide the beam. The system may include optical element(s), including a focusing lens, configured to direct the structured light towards the target volume. The system may include additional optical element(s) configured to direct a non-reflection output response from the target volume towards a detector along a response optical path.
G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
81.
METHOD AND SYSTEMS FOR A MACHINE-ASSISTED DISCOVERY OF CHONDROITINASE ABC COMPLEXES TOWARDS SUSTAINED NEURAL REGENERATION
Disclosed are systems and methods that provide a framework for machine-assisted discovery of Chondroitinase ABC (ChABC) complexes towards sustained neural regeneration. In some embodiments, the framework may leverage a determination of a diverse set of tailor-made random copolymers that complex and stabilize ChABC at physiological temperature. The copolymer designs, which are based on chain length and/or composition of the copolymers, may be identified using an active machine learning paradigm, which involves, but is not limited to, copolymer synthesis, testing for ChABC thermostability upon copolymer complexation, Gaussian Process Regression modeling and Bayesian optimization. Copolymers are synthesized by automated PET-RAFT, and thermostability of ChABC may be assessed by retained enzyme activity (REA) after a predefined interval of hours at 37° C.
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
Disclosed is a directionally emissive device that may radiates heat skywards, but reflectively blocks longwave heat exchange with the ground. Relative to traditional building envelopes, such devices can cool buildings in the summer and heat them in the winter. Such devices generally include a micropattemed layer that includes a pattern on an outer surface that imparts a directional emittance (E), the repeating pattern defined by a repeating unit having a first surface oriented in first direction and a second surface oriented in a second direction, the first surface and the second surface being asymmetrically arranged within the repeating unit. Such devices also include an infrared (IR) reflective layer on at least a portion of the second surface, the first surface being free of the IR reflective layer.
F28F 13/18 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by applying coatings, e.g. radiation-absorbing, radiation-reflectingArrangements for modifying heat transfer, e.g. increasing, decreasing by surface treatment, e.g. polishing
F28F 3/02 - Elements or assemblies thereof with means for increasing heat-transfer area, e.g. with fins, with recesses, with corrugations
F28F 5/00 - Elements specially adapted for movement
B64G 1/50 - Arrangements or adaptations of devices for control of environment or living conditions for temperature control
E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshineSimilar screens for privacy or appearance
83.
STABILIZATION OF LEAD IODIDE PEROVSKITE-BASED DEVICES
Perovskite-based devices are susceptible to degradation that stems from formation of oxidized iodine species which simultaneously facilitates degradation of both perovskite and hole transport layers. Improved devices are provided that utilized a halide perovskite layer disposed between a first electrode and a second electrode, where either the halide perovskite layer is adjacent to a reducing agent; and/or at least one intermediate layer comprising the reducing agent is between the halide perovskite layer and the first electrode, the second electrode, or both.
C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
84.
LEARNING CLOSED-LOOP CONTROL POLICIES FOR MANUFACTURING
Institute of Science and Technology Austria (Austria)
Universita Della Svizzera Italiana (Switzerland)
Inventor
Foshey, Michael J.
Matusik, Wojciech
Bickel, Bernd
Piovarci, Michal
Rusinkiewicz, Szymon
Didyk, Piotr
Abstract
A manufacturing system and method involves learning a self-correcting closed-loop control policy through machine reinforcement learning for a manufacturing process that involves on-the-fly adjustment of process parameters to handle inconsistencies in the manufacturing process and material formulations, and controlling operation of a tool configured to interact with or produce a product including dynamically adjusting at least one parameter of the manufacturing process to thereby dynamically adjust operation of the tool based on qualitative performance information derived from at least one sensor applied as feedback to the closed-loop control policy learned through machine reinforcement learning.
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
85.
SUBSTITUTED HETEROCYCLES AS ALDEHYDE DEHYDROGENASE INHIBITORS
Provided herein are novel heterocyclic compounds, for example, compounds of Formula (IV-C). Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
Provided herein are novel heterocyclic compounds, for example, compounds of Formula (IV-C). Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 215/50 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 491/048 - Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Some embodiments of the invention provide methods that can create large area complex patterns for nanoimprint molds without or with very litter of the use of the charged beam or photon beam direct-writing of nanostructures. Some embodiments of the invention use (i) Fourier nanoimprint patterning (FNP), (ii) edge-guided nanopatterning (EGN), and (iii) nanostructure self-perfection, and their combinations.
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
87.
SYSTEM AND METHOD FOR SUBJECT-EFFICIENT CLINICAL RANDOMIZED CONTROLLED TRIALS
Systems and methods for making a randomized control trial (RCT) more data efficient may include receiving subject data for subjects in control arm(s) or treatment arm(s) of an already-conducted RCT; estimating individual treatment effects (ITEs) by utilizing synthetic intervention (SI) to estimate counterfactual treatment responses for each patient in the control arm and counterfactual control responses for each patient in the treatment arm; conducting a two-sided hypothesis test, using the ITE for each patient and the control data; estimating a null distribution of the ITE for each patient under a null hypothesis by repeatedly resampling the control data to provide samples, and running SI with the samples; using the null distribution to determine a critical value achieving a desired significance level; and conducting the two-sided hypothesis test using the critical value. The methods may include conducting a pilot study and trend-adaptive algorithm to arrive at a sample size estimate.
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
Embodiments are disclosed for converting audio data to studio quality audio data. The method includes obtaining an audio data having a first quality for conversion to studio quality audio. A first machine learning model predicts a set of acoustic features. A spectral mask is applied to the audio data during the prediction of the set of acoustic features. A second machine learning model generates studio quality audio from the set of acoustic features and the audio data.
G10L 25/18 - Speech or voice analysis techniques not restricted to a single one of groups characterised by the type of extracted parameters the extracted parameters being spectral information of each sub-band
G10L 25/24 - Speech or voice analysis techniques not restricted to a single one of groups characterised by the type of extracted parameters the extracted parameters being the cepstrum
G10L 25/60 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination for measuring the quality of voice signals
89.
SYSTEM FOR GENERATING SOUND WAVES FOR AT LEAST TWO SEPARATE ZONES OF A SINGLE SPACE AND ASSOCIATED METHOD
The invention relates to a system for generating sound waves for at least two separate zones of a single space. The system includes, for each zone of said space: at least one array of high-frequency loudspeakers forming a directional sound wave; and at least one low-frequency loudspeaker. The system also comprises means for audio processing of the signals transmitted to the loudspeakers, which means control at least one loudspeaker to generate destructive sound waves in at least one zone of said space and to obtain distinct sound contents in said at least two distinct zones of said space. To do this, the audio-processing means control each low-frequency loudspeaker individually and each array of high-frequency loudspeaker mutually in order to generate the destructive sound waves.
H04S 7/00 - Indicating arrangementsControl arrangements, e.g. balance control
H04R 1/40 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by combining a number of identical transducers
Metasurfaces and systems including metasurfaces for imaging and methods of imaging are described. In one embodiment, a method for acquiring images by an imaging system comprising a metalens includes: illuminating the metalens; acquiring light passing through the metalens as a first image by an image sensor; and processing the first image into a second image that is a deconvolved version of the first image by a post-processing engine. The metalens includes a plurality of nanoposts carried by a substrate.
Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.
G11C 11/4074 - Power supply or voltage generation circuits, e.g. bias voltage generators, substrate voltage generators, back-up power, power control circuits
G11C 11/4094 - Bit-line management or control circuits
G11C 11/4097 - Bit-line organisation, e.g. bit-line layout, folded bit lines
H03K 19/20 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits characterised by logic function, e.g. AND, OR, NOR, NOT circuits
ddd ≤10 cm. The solar absorption material may include a plurality of layers, including a carbonaceous light absorbing layer and at least one additional layer. The at least one additional layer may include a reflective layer disposed below the carbonaceous light absorbing layer, an anti-reflection layer disposed above the carbonaceous light absorbing layer, and/or a first layer disposed above the carbonaceous light absorbing layer and any anti-reflection layer, where the first layer may consist of an anti-scaling layer, a photocatalyst layer, or a selective mineral adsorption layer.
Vinylcyclobutane (VCB) homopolymers, VCB copolymers and processes for making same. The VCB homopolymers and copolymers have a polydispersity (PDI) of less than 3.0 and are made by contacting VCB monomer in the presence of a single-site metallocene, post metallocene, or half metallocene, and an activator, under sufficient reaction conditions to produce a VCB (co)polymer having the narrow PDI of less than 3.0. The resulting poly(vinylcyclobutane) polymers have increased crystallinity and melting point properties (Tm of 165° C. to 246° C.) that are comparable to conventional polyolefins such as polyethylene (typical Tm <135° C.) and polypropylene (typical Tm <165° C.).
C08F 10/14 - Monomers containing five or more carbon atoms
C08F 4/659 - Component covered by group containing a transition metal-carbon bond
C08F 4/6592 - Component covered by group containing a transition metal-carbon bond containing at least one cyclopentadienyl ring, condensed or not, e.g. an indenyl or a fluorenyl ring
An organic optoelectronic device comprises a first electrode, a first charge transport layer positioned over the first electrode, a first emissive layer positioned over the first charge transport layer, a second charge transport layer positioned over the first emissive layer, a second electrode positioned over the second charge transport layer, and a top organic emissive layer positioned over the second electrode, configured to convert surface plasmon polaritons on a surface of the second electrode to light. A white emitting organic optoelectronic device and a method for transferring energy to acceptor molecules are also disclosed.
H10K 59/95 - Assemblies of multiple devices comprising at least one organic light-emitting element wherein all light-emitting elements are organic, e.g. assembled OLED displays
Systems and methods disclosed herein provide for a passive backscattering beamformer based on large-area electronics (LAE). Low power is critical for distributed nodes in future IoT/5G networks. A key emerging solution is using ubiquitous 2.4 GHz Wi-Fi infrastructure with passive backscattering nodes, for low-power communication. LAE enables monolithic integration of devices over large and flexible substrates, with recent advances into the gigahertz regime opening new opportunities for wireless systems. An LAE passive backscattering beamformer is chosen that is capable of (1) enhancing the backscattered signal power in a scalable manner enabled by LAE's monolithic integrability over meter-scale area; (2) configuration between constructive/destructive beamforming; (3) frequency-shift keying for data modulation and SNR enhancement, by shifting the signal away from the incident interferer; and (4) frequency division multiplexing for increasing data bandwidth.
The present disclosure provides compositions of matter comprising a polymer or peptide bound to an oxidized amino acid or an analog thereof. The present disclosure also provides packaging materials, consumer products, and cosmetic products comprising the compositions of matter disclosed herein.
A design methodology and tool called INFORM are provided that use a two-phase approach for sample-efficient constrained multi-objective optimization of real -world nonlinear systems. In the first optional phase, one may modify a genetic algorithm (GA) to make the design process sample-efficient, and may inject candidate solutions into the GA population using inverse design methods. The inverse design techniques may be based on (i) a neural network verifier, (ii) a neural network, and (iii) a Gaussian mixture model. The candidate solutions for the next generation are thus a mix of those generated using crossover/mutation and solutions generated using inverse design. At the end of the first phase, one obtains a set of nondominated solutions. In the second phase, one chooses one or more solution(s) from the non-dominated solutions or another reference solution to further improve the objective function values using inverse design methods.
G06N 3/126 - Evolutionary algorithms, e.g. genetic algorithms or genetic programming
G06F 18/2115 - Selection of the most significant subset of features by evaluating different subsets according to an optimisation criterion, e.g. class separability, forward selection or backward elimination
98.
METHODS OF SCREENING INHIBITORS OF BIOMOLECULAR INTERACTIONS USING PHASE SEPARATION AS IN CELLULO READ-OUT
Provided herein are methods of identifying an inhibitory activity of an exogeneous agent that disrupts binding of a target peptide to a biomolecule using phase separation as in cellulo read-out. Provided herein also are kits for the methods, pharmaceutical compositions comprising the agents screened by the methods, methods of preparing the pharmaceutical composition, and methods of treating a disease or condition in a subject in need thereof by administering the pharmaceutical composition.
Disclosed herein are methods, systems, and devices including a tunable coupler design that harnesses interference due to higher energy levels to achieve zero static ZZ coupling between the two qubits. Biasing to zero ZZ interaction, a fast perfect entangler is realized with parametric flux modulation in less than 20 ns. The disclosed coupler provides very fast gates between far-detuned fixed frequency qubits, and is a crucial building block in scaled quantum computers.
The present disclosure relates to a method for designing a sound stage control (SSC) processor to control a sound stage rendered by distributed loudspeakers in acoustically reflective environments. The method includes step A, including designing of Alignment Stage filters, step B, including measuring the response from the different loudspeakers to the same control points with the Alignment Stage filters applied, step C including pre-processing of the response obtained in step B by time-windowing impulse responses in a frequency-dependent manner, a step D including inverting of pre-processed IRs obtained from the step C; and a step E including cascading of the Alignment Stage and SSC Stage to program the SSC processor.
