Abstract

The present disclosure provides a device comprising a frame, a 3-axis gantry operably coupled to the frame, a scratch tip tool removably coupled to the 3-axis gantry, a sample holder operably coupled to the frame configured to receive a culture vessel containing cells, and at least one processing unit. The processing unit is configured to receive information comprising a target pattern and cause the scratch tip tool to scratch the cells in the target pattern. The device enables automated and precise creation of scratch patterns in cell cultures for wound healing and migration assays.

IPC Classes  ?

• B25J 9/02 - Programme-controlled manipulators characterised by movement of the arms, e.g. cartesian co-ordinate type
• B25J 9/16 - Programme controls
• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
• C12M 3/02 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
• C12M 3/04 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers

Abstract

Described herein are methods and kits for assaying the rancidity of human milk, in particular breastmilk. Specifically, methods and kits thereof for determining whether a subject is a high-lipase producer of breastmilk by assessing lipase activity levels and determining whether a breastmilk sample has become rancid by assessing the extent of lipolysis (or potential rancidity) by measuring glycerol accumulation are provided. Kits that use test strips are also described.

IPC Classes  ?

• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol

Abstract

Provided herein are methods of treating a cancer, comprising administering to a patient diagnosed with cancer an effective amount of a thymidine analog and a thymidylate synthase inhibitor, wherein the thymidine analog incorporates into DNA.

IPC Classes  ?

• A61K 31/7072 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

e.g.e.g.e.g., outward expansion of an edge of a tissue or inward migration resulting in tissue densification, is controlled by the position of the illuminated region with respect to the tissue.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts

Abstract

Disclosed is a device that will take radiometric images of the shortwave spectrum from 0.2-2 μm, which can then be processed into a spherical panoramic image. This single source of data can then be used to produce a wide range of functional outputs for radiative energy analysis, from architectural performance and thermal comfort analysis to replacing the array of sensors required to make specific biometeorological measurements, such as Global Horizontal Irradiance (GHI), Direct Normal Irradiance (DNI), Diffuse Horizontal Irradiance (DHI), Sky View Factor (SVF), and/or Global Tilted Irradiance (GTI). The data is also combined with a longwave array detector to produce full-spectrum radiative energy measurements.

IPC Classes  ?

• H04N 23/11 - Cameras or camera modules comprising electronic image sensorsControl thereof for generating image signals from different wavelengths for generating image signals from visible and infrared light wavelengths
• G01J 1/02 - Photometry, e.g. photographic exposure meter Details
• G01J 1/04 - Optical or mechanical part
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G01J 5/02 - Constructional details
• G01J 5/04 - Casings
• G01J 5/0804 - Shutters
• G01J 5/0875 - WindowsArrangements for fastening thereof
• G01J 5/10 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors
• H04N 23/13 - Cameras or camera modules comprising electronic image sensorsControl thereof for generating image signals from different wavelengths with multiple sensors
• H04N 23/23 - Cameras or camera modules comprising electronic image sensorsControl thereof for generating image signals from infrared radiation only from thermal infrared radiation
• H04N 23/55 - Optical parts specially adapted for electronic image sensorsMounting thereof

Abstract

The present disclosure provides devices, computing systems, and methods for optical imaging. The device may comprise an aperture having an optical axis and comprising a first portion and a second portion. The second portion may comprise an optical modulation element configured to modulate incident light such that light output via the first portion is different than light output via the second portion. The device may comprise a first plurality of sensors configured to detect the light output via the first portion of the aperture. The device may comprise a second plurality of sensors configured to detect the light output via the second portion of the aperture. The device may comprise a storage element configured to cause, based on a single capture operation, storage of a first image captured from the first plurality of sensors and a second image captured from the second plurality of sensors.

IPC Classes  ?

• H04N 23/45 - Cameras or camera modules comprising electronic image sensorsControl thereof for generating image signals from two or more image sensors being of different type or operating in different modes, e.g. with a CMOS sensor for moving images in combination with a charge-coupled device [CCD] for still images
• H04N 13/257 - Colour aspects
• H04N 13/271 - Image signal generators wherein the generated image signals comprise depth maps or disparity maps
• H04N 23/55 - Optical parts specially adapted for electronic image sensorsMounting thereof

Abstract

Disclosed are systems and techniques for generating and steering laser beams onto atoms for performing locally addressed quantum gate operations. A system may include (i) a high-speed acousto-optic modulator (AOM) for producing a single input beam, (ii) a phase-only spatial light modulator (SLM) for imprinting a phase pattern on the single input beam, the phase pattern being chosen such that after a lens positioned after the SLM, the single input beam is divided into a pattern of secondary beams that correspond to the positions of the atoms or ions in a quantum computer, the lens after the SLM being positioned so the secondary beams are focused to form an image on a digital micromirror device (DMD) amplitude modulator, (iii) a compensation grating after the DMD, in the path of the secondary beams, and (iv) an objective lens after the compensation grating to image the secondary beams onto an atomic array.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• G02F 1/33 - Acousto-optical deflection devices
• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers

Abstract

The present disclosure provides a host cell for optogenetic protein production, comprising: a first sequence comprising a first promoter operably linked to a gene of interest; a second sequence comprising a second promoter operably linked to a gene encoding a light-sensitive transcription factor, wherein the light-sensitive transcription factor is configured to induce expression of the gene of interest upon activation by light; and a first selection marker. The gene of interest, first promoter, second gene, second promoter, and first selection marker are either integrated at a first locus, or the gene of interest, first promoter, and first selection marker are integrated at the first locus while the second gene, second promoter, and a second selection marker are integrated at a second locus. The disclosure also provides systems and methods for optogenetic protein production using the host cell.

IPC Classes  ?

• C07K 14/39 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from fungi from yeasts
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Abstract

The present disclosure provides a method for training an interpretable differentiable logic network (DLN) for classification tasks. The method includes initializing a DLN and iteratively training the DLN by alternating between two phases for a predetermined number of iterations. In a first phase, neuron functionality parameters are learned while fixing neuron connections such that a link between any two neurons is either 0 or 1. In a second phase, neuron connection parameters are learned while fixing neuron functionalities such that each neuron performs only one discrete logic operation among all possible operations. The DLN comprises a ThresholdLayer to convert continuous inputs to binary values, at least one LogicLayer to perform binary logic operations, and a SumLayer to aggregate outputs for classification.

IPC Classes  ?

• G06N 3/08 - Learning methods
• G06N 3/042 - Knowledge-based neural networksLogical representations of neural networks
• G06N 3/043 - Architecture, e.g. interconnection topology based on fuzzy logic, fuzzy membership or fuzzy inference, e.g. adaptive neuro-fuzzy inference systems [ANFIS]
• G06N 3/06 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons
• G06N 3/048 - Activation functions
• G06N 3/045 - Combinations of networks

Abstract

The present disclosure provides a method for predicting coincident peak events in electricity demand. The method includes receiving historical electrical usage data and forecasted demand data for a given timeframe, training a simulation engine based on the historical data, generating a plurality of load scenarios for a target period of time using the trained simulation engine, and computing a probability that the target period of time will include a new record high peak in electricity demand based on the generated scenarios. The method enables accurate prediction of peak demand events without relying on weather or economic data, allowing utilities and consumers to better manage electricity usage and reduce costs associated with peak demand periods.

IPC Classes  ?

• G06F 18/20 - Analysing
• G06F 18/214 - Generating training patternsBootstrap methods, e.g. bagging or boosting
• G06N 20/00 - Machine learning

Abstract

Disclosed is a simple and cost-effective technique for generation of high-throughput aerosols of uniform-diameter submillimeter-size core-shell particles. An aerosol may be created by using, e.g., a first tube filled with liquid and having a small hole through a sidewall, then passing a fluid through the liquid via a second tube passing partially though the first tube at a location above the small hole, forming coaxial flow through the small hole. The diameter of generated core-shell particles scales with the inner and outer diameter of the gas tube nozzle, enabling control on the size of the produced particles. Further disclosed is a simple, scalable and cost-effective technique that enables microencapsulation of various materials. Including highly viscous materials, into sub-10 μm particles. A specially designed atomizing tube interacts with bubbles formed in a liquid comprising a plurality of immiscible liquid layers to generate aerosols of droplets which have layered core-shell structure.

IPC Classes  ?

• B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying
• B01F 33/3011 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream

Abstract

The present disclosure provides a method of inhibiting telomerase activity to reduce human herpesvirus (e.g., HMCV, EBV, HSV-1, and/or HHV-6/7/8) replication. The method comprises treating cells with a telomerase inhibitor prior to and after HCMV infection. The telomerase inhibitor may be a pharmaceutical inhibitor such as BIBR1532 or MST312, or an siRNA construct targeting the hTERT catalytic subunit of telomerase. Treatment with the telomerase inhibitor results in reduced viral titer, decreased viral gene expression, and diminished viral protein levels across different temporal phases of herpesvirus infection. The method provides a novel approach for inhibiting herpesvirus replication through targeting of host cell telomerase activity.

IPC Classes  ?

• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/22 - Antivirals for DNA viruses for herpes viruses
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid

Abstract

The present disclosure provides compositions and methods for prime editing with improved editing efficiency and/or reduced indel formation by inhibiting the DNA mismatch repair path way while conducting prime editing of a target site. Accordingly, the present disclosure provides a method for editing a nucleic acid molecule by prime editing that involves contacting a nucleic acid molecule with a prime editor, a pegRNA, and an inhibitor of the DNA mismatch repair pathway, thereby installing one or more modifications to the nucleic acid molecule at a target site with increased editing efficiency and/or lower indel formation. The present disclosure further provides polynucleotides for editing a DNA target site by prime editing comprising a nucleic acid sequence encoding a napDNAbp, a polymerase, and an inhibitor of the DNA mismatch repair pathway, wherein the napDNAbp and polymerase is capable in the presence of a pegRNA of installing one or more modifications in the DNA target site with increased editing efficiency and/or lower indel formation. The disclosure further provides, vectors, cells, and kits comprising the compositions and polynucleotides of the disclosure. The present disclosure also provides compositions and methods for prime editing with improved editing efficiency and/or reduced indel formation with modified prime editor fusion proteins. The disclosure further provides, vectors, cells, and kits comprising the compositions and polynucleotides of the disclosure.

IPC Classes  ?

• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

The present disclosure provides a rapid, facile, economical, and highly scalable method for producing selenoneine. The method involves SenA, hercynine, a selenosugar, and optionally a reductant, and a single, high-yielding enzymatic step in, e.g., a neutral-pH aqueous buffer and at ambient temperature. It can achieve yields of around 5 grams selenoneine per liter reaction with approximate costs of $100 per gram selenoneine.

IPC Classes  ?

• C12P 17/10 - Nitrogen as only ring hetero atom
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 1/20 - BacteriaCulture media therefor
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12R 1/19 - Escherichia coli

Goods & Services

Jewelry, namely, rings and tie tacks. Decals, loose leaf binders, ballpoint and lead pencils, writing paper; stationery and file folders, notebooks, yearbooks, and postcards. Handbags, umbrellas, knapsacks, and duffle bags. Drinking glasses, mugs, cups, coasters (not of paper and not of linen), insulation sleeves for canned drinks, serving trays, decorative boxes. Cloth pennants, cloth flags, cloth banners, towels. Clothing, namely, decorative t-shirts (not being undergarments), sweaters, jackets, sweatshirts, sweatpants, shorts, ties, caps, hats, sunvisors, headbands, wristbands, shoes, socks, rain ponchos, belts. Educational services, namely, providing instruction and training at the undergraduate, graduate and postgraduate levels; entertainment services in the nature of presentation of a variety of intercollegiate sporting events, including football, baseball, ice hockey, basketball, soccer, and track and field.

Abstract

Systems and methods are provided for measuring analytes (e.g., greenhouse gases) in the air over a field in an agricultural setting. The existing equipment of a center pivot and an attached arm can be used by adding reflectors and/or point sensors on the arm and an analyzer unit on the center pivot. The analyte concentration in the air can be detected down to a sensitivity of 1 part per billion or less.

IPC Classes  ?

• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01W 1/02 - Instruments for indicating weather conditions by measuring two or more variables, e.g. humidity, pressure, temperature, cloud cover or wind speed

Abstract

Systems and methods are provided for measuring analytes in the air over an area. Open-path sensing equipment can be used to measure the concentration of one or more analytes over the area. The open-path sensing equipment can include at least one light source configured to provide light at a respective predetermined wavelength, a detector, and a plurality of mirrors. The open-path sensing equipment can further include and/or be operated with electronics, such as field programmable gate array (FPGA) electronics.

IPC Classes  ?

• G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
• G01N 21/47 - Scattering, i.e. diffuse reflection
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• B64U 101/35 - UAVs specially adapted for particular uses or applications for science, e.g. meteorology

Abstract

Disclosed are a method and system for thermal stabilization of pharmaceutical formulations containing enveloped and nonenveloped viruses. The disclosed method of Rapid Room Temperature Aerosol Dehydration (RTAD) provides a scalable system for continuous dehydration of liquid pharmaceutical and biopharmaceutical formulations that provides thermal stabilization of biological drugs by converting liquid drugs into powder form, enabling their transportation, storage and handling at room temperature. The disclosed process can generate sprays/aerosols with droplets that are 100x smaller (0.2-20 μm) than existing spray drying technologies and perform dehydration, without applying heat, which mitigates the risk of damage of thermolabile biologicals and provides a significant reduction in energy requirements. The technology has demonstrated superiority of the system over traditional spray drying and freeze drying with respect to energy consumption, biological activity, scalability, powder solubility, particle size and size uniformity, and high-quality of produced inhalable and reconstitutable biologic formulations.

IPC Classes  ?

• B01D 1/18 - Evaporating by spraying to obtain dry solids
• B05B 9/04 - Spraying apparatus for discharge of liquid or other fluent material without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible containerSpraying apparatus for discharge of liquid or other fluent material without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pump
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61M 11/02 - Sprayers or atomisers specially adapted for therapeutic purposes operated by air pressure applied to the liquid to be sprayed or atomised
• B05B 7/06 - Spray pistolsApparatus for discharge with one outlet orifice surrounding another approximately in the same plane

Abstract

A method may be provided for producing a voltage across a magnetized plasma. The techniques may include generating, within a plasma device having at least one outer boundary that defines walls, at least one magnetic field including an axially directed magnetic field in an open field line configuration. The axial-directed magnetic field may confine a plasma in a direction perpendicular to the magnetic field. The techniques may also include generating at least one electric field within the plasma device.

IPC Classes  ?

• H05H 1/04 - Arrangements for confining plasma by electric or magnetic fieldsArrangements for heating plasma using magnetic fields substantially generated by the discharge in the plasma
• H05H 1/16 - Arrangements for confining plasma by electric or magnetic fieldsArrangements for heating plasma using applied electric and magnetic fields

Goods & Services

Clothing, namely, t-shirts, polo shirts, long sleeve shirts, sweatshirts, fleece shirts, shorts, sweatpants, jogging pants, scarves, socks; headgear, namely, hats, beanies; footwear Entertainment services, namely, arranging and conducting of competitions in the field of a variety of intercollegiate sporting events; Providing collegiate athletic and sporting events; Teaching, training, tutoring and courses of instruction at the undergraduate, graduate and post-graduate level; Educational services in the nature of undergraduate, graduate and post-graduate level schools; Education services in the nature of courses at the university level; Educational services, namely, providing instruction and training in the fields of undergraduate, graduate and post graduate level education

Goods & Services

Clothing, namely, t-shirts, polo shirts, long sleeve shirts, sweatshirts, fleece shirts, shorts, sweatpants, jogging pants, scarves, socks; headgear, namely, hats, beanies; footwear

Abstract

Systems and methods are provided for measuring analytes (e.g., greenhouse gases) in the air over a field in an agricultural setting. The existing equipment of a center pivot and an attached arm can be used by adding reflectors and/or point sensors on the arm and an analyzer unit on the center pivot. The analyte concentration in the air can be detected down to a sensitivity of 1 part per billion or less.

IPC Classes  ?

• G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
• G01N 1/22 - Devices for withdrawing samples in the gaseous state
• G01N 1/24 - Suction devices

Abstract

Atomic magnetometers are usually used as scalar sensors to measure the magnitude of the magnetic field. The magnetic field is converted to a frequency that can be measured with high fractional precision. There are no comparable methods for measuring vector magnetic field components. Common sensors, such as flux-gate and SQUID magnetometers, suffer from calibration and orthogonality uncertainty. Disclosed is a method of using an atomic magnetometer to measure the magnitude and two polar angles of the magnetic field vector. The two polar angles are dimensionless quantities and can be measured with high fractional precision. Also disclosed is a particular measurement procedure that is immune to systematic effects in such measurements.

IPC Classes  ?

• G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping

Abstract

Systems and methods are provided for measuring analytes in the air over an area. Open-path sensing equipment can be used to measure the concentration of one or more analytes over the area. The open-path sensing equipment can include at least one light source configured to provide light at a respective predetermined wavelength, a detector, and a plurality of mirrors. The open-path sensing equipment can further include and/or be operated with electronics, such as field programmable gate array (FPGA) electronics.

IPC Classes  ?

• G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
• B64U 10/13 - Flying platforms
• B64U 101/35 - UAVs specially adapted for particular uses or applications for science, e.g. meteorology

Abstract

According to various embodiments, a power converter circuit is disclosed. The power converter circuit includes at least two vertically stacked printed circuit boards (PCBs) comprising a top PCB and a bottom PCB. The power converter circuit further includes at least one multiphase coupled inductor placed between the top PCB and the bottom PCB. The top PCB is coupled to the bottom PCB via at least one conductive winding of the multiphase coupled inductor. The power converter circuit further includes at least one circuit module placed above the top PCB and at least one power source placed below the bottom PCB. The multiphase coupled inductor is configured to deliver current vertically from the bottom PCB to the top PCB.

IPC Classes  ?

• H02M 1/14 - Arrangements for reducing ripples from DC input or output
• H01F 27/06 - Mounting, supporting, or suspending transformers, reactors, or choke coils
• H01F 27/255 - Magnetic cores made from particles
• H01F 27/30 - Fastening or clamping coils, windings, or parts thereof togetherFastening or mounting coils or windings on core, casing, or other support
• H02M 7/00 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output
• H05K 1/14 - Structural association of two or more printed circuits
• H05K 1/18 - Printed circuits structurally associated with non-printed electric components

Abstract

Techniques for reel-to-reel assessment of a high-temperature superconducting (HTS) tape are provided. The techniques include a cryocooler-powered cryogenic system configured to cool the HTS tape in a background magnetic field. The cryocooler-powered cryogenic system may be free of liquid cryogenic. The cryocooler-powered cryogenic system may include a measurement zone, where the magnetic field is perpendicular to the path of the HTS tape. The techniques may also include a Hall sensor array within the measurement zone. The Hall sensor array may be configured to scan a magnetic field at a surface of the HTS tape to measure a screening-current-induced field and separate it from the background magnetic field. The techniques may also include a data acquisition (DAQ) module operably coupled to the Hall sensor array. The DAQ module may be configured to oversample Hall voltages.

IPC Classes  ?

• G01R 31/08 - Locating faults in cables, transmission lines, or networks
• G01R 33/07 - Hall-effect devices
• G01R 33/12 - Measuring magnetic properties of articles or specimens of solids or fluids
• G01R 33/20 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance

Abstract

Disclosed herein are compositions and methods for the generation of peptide macrocycles from peptide substrates for ATP-grasp enzymes. The peptide substrates contain sufficient linkage cites to produce monocyclic, bicyclic, tricyclic, or multicyclic peptides comprising macrocyclic linkages selected from ω-ester linkages, ω-amide linkages, ω-thioester linkages, and combinations thereof.

IPC Classes  ?

• C12P 21/00 - Preparation of peptides or proteins
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 9/10 - Transferases (2.)
• C12N 9/90 - Isomerases (5.)
• C07K 1/07 -

Abstract

Functionalized polycaryophyllenes are described herein. Such functionalized polycaryophyllenes can serve as additives in various compositions or can be employed as reactants to provide polymeric species having a variety of structures.

IPC Classes  ?

• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
• C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCompositions of derivatives of such polymers
• C09D 165/00 - Coating compositions based on macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCoating compositions based on derivatives of such polymers

Abstract

Disclosed are devices, systems, and techniques for decontaminating a gas or aerosol. Such techniques may be utilized, e.g., in conjunction with existing nebulizers or atomizers, or with residential, commercial, or industrial HVAC systems. The devices may include a housing configured to allow a gas or aerosol to pass from an inlet, through the housing, to an outlet. The devices may include a dielectric barrier discharge (DBD) element positioned in the opening or covering an end of the opening. The DBD element may be configured to generate a plasma and configured to allow the gas or aerosol to pass along or through a surface of the DBD element. When passing through the plasma, a disinfectant compound is created in the gas or aerosol, allowing for the gas or aerosol to be decontaminated. The decontaminated gas or aerosol can then be sent to, e.g., a mask, a room, etc.

IPC Classes  ?

• A61L 9/22 - Ionisation
• A61L 9/14 - Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances

Abstract

A platform for automated design of gene-editing experiments includes one or more processing units and a non-transitory computer-readable storage device. The storage device contains instructions that, when executed, configure the processing units to perform a method. The method includes receiving a meta request with information about a requested gene-editing experiment, configuring an ordered list of tasks via a reasoning framework, and implementing tasks via a Task Executor module utilizing state machines. The Task Executor connects to external APIs, provides instructions to a User-Proxy Agent module, and receives user input. The User-Proxy Agent forms prompts based on current state instructions, user requests, interaction history, and API results to determine appropriate actions. The platform outputs recommendations responsive to the meta request.

IPC Classes  ?

• G06N 3/126 - Evolutionary algorithms, e.g. genetic algorithms or genetic programming
• G06F 16/334 - Query execution
• G06F 16/338 - Presentation of query results
• G16B 40/20 - Supervised data analysis

Abstract

A thermal plasma can be generated using a pair of electrodes spaced apart from each other by a gap along a first direction. One or more reactants can be conveyed into and/or through at least a portion of the generated plasma. For example, the portion of the generated plasma can subject the reactant(s) to a temperature of at least 1000 K. As a result, the one or more reactants can undergo a thermochemical reaction that converts the one or more reactants into one or more products.

IPC Classes  ?

• H05H 1/24 - Generating plasma
• H05H 1/48 - Generating plasma using an arc
• H01J 37/32 - Gas-filled discharge tubes
• H05H 1/34 - Details, e.g. electrodes, nozzles

Abstract

The present invention is based, in part, on the identification of a minimal region of the SS18-SSX fusion oncoprotein that mediates a direct, high-affinity interaction between the mSWI/SNF complex and the nucleosome acidic patch, and methods and agents of modulating the interaction between the SS18-SSX fusion protein and H2A K119Ub-marked nucleosomes to treat synovial sarcoma.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A rare earth doped single crystal diamond showing photoluminescence using off-resonant excitation at 853 nm and having a full width half maximum spectral linewidth at 1508 nm of less than 1.0 nm. There is also disclosed a method of producing rare earth doped single crystal diamond. A single crystal diamond is provided, and a rare earth metal is implanted into the single crystal diamond using ion implantation. The implanted single crystal diamond is then annealed at a pressure of at least 5 GPa and a temperature of at least 1600°C.

IPC Classes  ?

• C23C 14/48 - Ion implantation
• C30B 29/06 - Silicon
• C30B 33/02 - Heat treatment
• C30B 33/04 - After-treatment of single crystals or homogeneous polycrystalline material with defined structure using electric or magnetic fields or particle radiation
• C23C 14/06 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
• C30B 29/04 - Diamond

Abstract

Provided herein are rhodoquinone mimetics, including compounds defined by Formula I and Formula II. Also provided are methods, uses, and kits involving the disclosed compounds and pharmaceutical compositions thereof for treating and/or preventing a disease (e.g., a metabolic disorder (e.g., obesity, diabetes), a hypoxia related disease (e.g., a proliferative disease, inflammatory disease, neuromuscular disorder, neurodegenerative disorder, hypoxia, ischemia, oxidative stress, or a mitochondrial DNA related disorder), or a disease resulting from rhodoquinone depletion (e.g., a proliferative disease, inflammatory disease, neuromuscular disorder, metabolic disorder, or neurodegenerative disorder)) in a subject.

IPC Classes  ?

• C07C 217/84 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
• C07C 225/28 - Compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly-bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of non-condensed quinone rings
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Disclosed is a method to control and manipulate floating water droplets. More particularly, disclosed are the self-assembly and pattern formation of electrically charged water droplets that are floating at an oil-gas interface. Also shown is that the assembly occurs because of electrostatic interactions between the drops. It is shown that the depth of the oil bath plays a significant role in the distance between the drops assembled at the interface. The relevance of the type of the boundary containing the entire system is highlighted by showing that even drops with a net zero electric charge can self-assemble under certain conditions. Furthermore, disclosed are ways to control the motion and the assembly of the drops at an interface.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The present disclosure provides systems, devices, and methods for using a user interface associated with musical composition. An example method may comprise outputting interface objects representing musical properties and establishing hierarchical relationships between the objects. A first interface object may visually represent a first musical property. A hierarchical relationship may be determined between the first object and a second object, indicating inheritance of the first property. Changes to the first property in the first object may update the second object.

IPC Classes  ?

• G10H 1/38 - Chord
• G06F 16/683 - Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually using metadata automatically derived from the content
• G10H 1/40 - Rhythm
• G10H 7/02 - Instruments in which the tones are synthesised from a data store, e.g. computer organs in which amplitudes at successive sample points of a tone waveform are stored in one or more memories
• G10H 7/08 - Instruments in which the tones are synthesised from a data store, e.g. computer organs by calculating functions or polynomial approximations to evaluate amplitudes at successive sample points of a tone waveform

Abstract

Described herein are substituted cubased and methods of making substituted cubanes.

IPC Classes  ?

• C07C 51/29 - Preparation of carboxylic acids or their salts, halides, or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
• C07C 61/125 - Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
• C07C 67/10 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
• C07C 69/753 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids

Abstract

1212 inhibitor.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/33 - Heterocyclic compounds

Abstract

An ink may be provided that includes a two-dimensional WS2 nanosheet and an organic solvent, such as water, and may be free of protective molecules and surfactants. Circuits may be provided that include this ink disposed onto a surface of a substrate (such as a flexible substrate) in various patterns, including, e.g., a superconducting qubit. The ink may be formed by sonicating, then centrifuging at a first speed, a sulfuric acid-KxWS2 solution, where x=0.3˜0.7, removing any supernatant from the centrifuged first suspension and replacing with water and sonicating the resulting WS2-water suspension, then centrifuging the result at a speed slower than the first speed, and using an upper portion of the resulting suspension.

IPC Classes  ?

• C09D 11/037 - Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment
• B41J 2/175 - Ink supply systems
• B41M 5/00 - Duplicating or marking methodsSheet materials for use therein
• B41M 7/00 - After-treatment of printed works, e.g. heating, irradiating
• C09D 11/322 - Pigment inks
• C09D 11/52 - Electrically conductive inks
• H05K 1/09 - Use of materials for the metallic pattern
• H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material

Abstract

Tile present disclosure relates to systems and methods for multiphase coupled inductors. The multiphase coupled inductor includes a magnetic ladder core assembly. The magnetic ladder core assembly includes: a first row of at least one rung, wherein an electrically conductive winding is wound around each rung of the at least one rung, forming a first row of electrical windings along a first direction; a second row of at least one rung, wherein an electrically conductive winding is wound around each rung of the at least one rung, forming a second row of electrical windings along the first direction; and a middle rail having a width along a second direction normal to the first direction, separating the first and the second row of electrical windings.

IPC Classes  ?

• H01F 3/10 - Composite arrangements of magnetic circuits
• H01F 27/28 - CoilsWindingsConductive connections
• H02M 3/158 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
• H02M 1/00 - Details of apparatus for conversion
• H01F 27/29 - TerminalsTapping arrangements

Abstract

Disclosed is a method for forming selenoneine or analogs thereof. The method may include phosphorylating sodium selenide to a selenophosphate, using adenosine triphosphate (ATP) and at least a first protein, generating a selenosugar by converting the selenophosphate using at least a second protein in the presence of a common sugar donor, and forming selenoneine or an analog thereof by combining the selenosugar with N,N,N-trimethyl-L-histidine or analogs thereof using at least a third protein. The method may include combining SenA, SenB, and SenC in an aqueous buffer at neutral pH and ambient temperature, and allowing SenA, SenB, and SenC to form selenoneine or an analog thereof in the presence of ATP, a common sugar donor, and sodium selenide.

IPC Classes  ?

• C12P 17/10 - Nitrogen as only ring hetero atom
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/10 - Transferases (2.)
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Abstract

Disclosed is a platform for fluorescence imaging of bulk RNA dynamics in living cells. The platform utilizes a technique including exposing a plurality of live cells configured to overexpress a WT or mutant ribonucleoside kinase UCK2 under control of an inducible promoter, a constitutively active promoter, or both, to a first quantity of a fluorescent nucleoside (such as fluorescent bicyclic and tricyclic cytidine analogues) for a first period of time.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

Antenna arrays, systems and methods using an algorithm-based array synthesis approach of designing and manufacturing an antenna array with non-uniform element distribution which fundamentally enables low side lobe beamforming capability over desired broadband/multiband frequency range across large scanning angles.

IPC Classes  ?

• H01Q 5/20 - Arrangements for simultaneous operation of antennas on two or more different wavebands, e.g. dual-band or multi-band arrangements characterised by the operating wavebands
• H01Q 3/38 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the relative phase or relative amplitude of energisation between two or more active radiating elementsArrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase by electrical means with variable phase-shifters the phase-shifters being digital
• H01Q 9/27 - Spiral antennas
• H01Q 9/28 - Conical, cylindrical, cage, strip, gauze or like elements having an extended radiating surface Elements comprising two conical surfaces having collinear axes and adjacent apices and fed by two-conductor transmission lines

Abstract

Processes that determine transcriptional regulation from genetic sequence data are described. Generally, computational models are trained to predict transcriptional regulatory effects, which can be used in several downstream applications. Various methods further develop research tools, develop and perform diagnostics, and treat individuals based on identified variants.

IPC Classes  ?

• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16B 40/20 - Supervised data analysis

Abstract

Described herein, are compositions and methods for preserving human milk, preventing rancidity of human milk, extending shelf life of human milk, and maintaining the nutritional properties of human milk. Specifically, the present disclosure provides, among other things, devices for storing preserved human milk and methods and compositions for preserving the same.

IPC Classes  ?

• A23B 11/18 - Preservation of milk or milk preparations by addition of preservatives
• A23C 9/20 - Dietetic milk products not covered by groups

Abstract

A processing unit leverages a decode stage's pool of instructions, thereby expanding available instruction choices and eliminating the need for expensive OoO techniques to identify reordering opportunities. The processing unit introduces instruction reordering by presenting an alternative instruction to the warp scheduler through the existing interface rather than offering the oldest instruction in each warp. The result is a simple and efficient OoO engine that operates predominantly in the processing unit's front end.

IPC Classes  ?

• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead

Abstract

Disclosed are techniques for training a graph language model (GEM). The techniques generally include training the GEM on a training corpus, expanding a current training knowledge graph into an expanded knowledge graph by distilling semantic information from the training corpus using neural inversion. The knowledge graph is only expanded when there is new data, and if convergence has not been reached, the method may include updating the training corpus by injecting the expanded knowledge graph into the training corpus, thereby making the expanded knowledge graph the current training knowledge graph. The training, expanding, and updating steps are repeated until convergence. The training corpus may be formed by parsing a dataset into chain graphs, where syntactic language information is represented as a chain sequence of one or more root nodes, and where semantic information from the seed knowledge graph is added as leaf nodes around each root node.

IPC Classes  ?

• G06N 5/02 - Knowledge representationSymbolic representation
• G06F 16/901 - IndexingData structures thereforStorage structures
• G06F 40/216 - Parsing using statistical methods
• G06N 3/02 - Neural networks
• G06N 5/022 - Knowledge engineeringKnowledge acquisition

Abstract

A method for quantum error correction includes: trapping and/or manipulating an array of qubits that include encoded neutral atoms or ions and forms a computational space; encoding the array of qubits to a state characterized in that an error during at least one of an idling, gate, or other operation results in a respective qubit transition to a disjointed state where that error can be detected without disturbing the qubits remaining in the computational space; performing a syndrome measurement of a quantum error correcting code; identifying the presence and location of an error by detecting the corresponding neutral atom or ion has left the computational space after performing the operation; identifying a logical error in the quantum error correcting code associated with a loss of qubit information based on the identified error location and results of the syndrome measurement; and adjusting subsequent computational steps based on the identified logical error.

IPC Classes  ?

• G06N 10/70 - Quantum error correction, detection or prevention, e.g. surface codes or magic state distillation
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

Mosquito attractant compositions that mimic the neural activity evoked by real human odor in the mosquito brain. The attractant compositions comprise 1-hexanol and linear long chain aldehydes that mimic human attractant odors and that differentiate humans from other animals. Methods for controlling malaria and dengue virus transmission as well as other diseases that are transmitted using mosquitos as vectors are included as are general methods and devices for attracting, killing, and controlling populations of mosquitos.

IPC Classes  ?

• A01N 31/02 - Acyclic compounds
• A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
• A01N 35/02 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio-analogues thereofDerivatives thereof, e.g. acetals
• A01P 19/00 - Pest attractants

Abstract

Use of high frequency waves, such a millimeter waves, in many circumstances is prevented due to their inability to diffract around common obstacles. Disclosed herein is a system and method for transforming an incident high frequency wave. The system includes meta-atom pairs that define a surface. The meta-atom pairs generate an electro-magnetic response by interacting with an incident wave. This electro-magnetic response can be modulated by applying voltage to the meta-atom pairs. The electro-magnetic response transforms the incident wave into an emitted wave based on its controlled properties. The system and method are able to, by changing the voltage applied, steer the emitted wave a full 360 degrees as wells as transmit it through the surface without significant power loss. Embodiments enable the transmission through or around many obstacles that would normally interfere with high frequency waves.

IPC Classes  ?

• H04W 72/542 - Allocation or scheduling criteria for wireless resources based on quality criteria using measured or perceived quality
• H04B 17/13 - MonitoringTesting of transmitters for calibration of power amplifiers, e.g. of gain or non-linearity
• H04B 17/391 - Modelling the propagation channel
• H04W 72/044 - Wireless resource allocation based on the type of the allocated resource
• H04W 72/0453 - Resources in frequency domain, e.g. a carrier in FDMA

Abstract

Systems and methods for batch correcting single-cell abundance data obtain a measurement value of each feature in a plurality of features originating from each cell in a plurality of cells. The cells collectively originate from a plurality of samples. Feature measurements for each cell are used to cluster the cells into clusters. Cluster assignments of each cell and an identity of a sample in the plurality of samples from which each cell originated are used to compute sample-level local inverse Simpson index (LISI) scores penalized by a measure of importance of cells in each sample. Scores are scaled and ordered before application of a Dixon's Q-test groups them into one or more groups. For each respective group, a common batch assignment is applied to each of the samples in the respective group.

IPC Classes  ?

• G16B 40/30 - Unsupervised data analysis
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Abstract

Disclosed is a technique for improving the throughput of a neural network, using multiplexing and demultiplexing of information. Specifically, the multiplexing may include receiving a plurality of inputs, generating transformed inputs by performing, via a multiplexing layer, a transformation to each input of the plurality of inputs, and combining the transformed inputs into a single compact representation of the plurality of inputs. The demultiplexing may include receiving an output from a neural network, generating a plurality of values by converting, via a demultiplexing layer, the output back into independent representations, and producing predictions for each input based on the plurality of values. Further improvements may be seen when pretraining of the neural network and/or high-throughput transformers are incorporated.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

A flat nanophotonic computational camera, which employs an array of skewed lenslets (meta-optics) and a learned reconstruction approach is disclosed herein. The optical array is embedded on a metasurface that with a height of approximately one micron, is flat and sits on the sensor cover glass at approximately 2.5 mm focal distance from the sensor. A differentiable optimization method continuously samples over the visible spectrum and factorizes the optical modulation for different incident fields into individual lenses. A megapizel image is reconstructed from a flat imager with a learned probabilistic reconstruction method that employs a generative diffusion model to sample an implicit prior. A method for acquiring paired captured training data in varying illumination conditions is proposed. The proposed flat camera design is assessed in simulation and with an experimental prototype, validating that the method is capable of recovering images from diverse scenes in broadband with a single nanophotonic layer.

IPC Classes  ?

• H04N 23/55 - Optical parts specially adapted for electronic image sensorsMounting thereof
• H04N 23/69 - Control of means for changing angle of the field of view, e.g. optical zoom objectives or electronic zooming

Abstract

Disclosed is a method for quantitative detection of a small, aberrant viral nucleic acid. The method includes combining a detection mixture with a sample, and allowing a reaction with the test mixture to begin. The sample includes an RNA sample. The detection mixture includes a Cas13 enzyme, a reporter, a sequence-specific CRISPR RNA (crRNA), and a buffer. The method includes determining a quantitative value representative of the reporter in the test mixture, where the quantitative value is a measure of an amount of target RNA present in the RNA sample.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Abstract

The present disclosure provides a rapid, facile, economical, and highly scalable method for producing selenoneine. The method involves SenA, hercynine, a selenosugar, and optionally a reductant, and a single, high-yielding enzymatic step in, e.g, aneutral-pH aqueous buffer and at ambient temperature. It can achieve yields of around 5 grams selenoneine per liter reaction with approximate costs of $100 per gram selenoneine.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 1/20 - BacteriaCulture media therefor
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12P 17/10 - Nitrogen as only ring hetero atom
• B01D 15/08 - Selective adsorption, e.g. chromatography
• C07D 23/64 -

Abstract

Disclosed herein are compounds of Structural Formula I. Compounds of Structural Formula I inhibit aldehyde dehydrogenase isoform 1a3 (ALDH1a3) and are useful for treating cancer, for example, metastatic or chemoresistant cancer, such as metastatic cancer resistant to chemotherapy. Also disclosed herein are compositions comprising compounds of Structural Formula I and uses of compounds of Structural Formula I for treating cancer, for example, metastatic or chemoresistant cancer.

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Disclosed is a method coupling automated microscopy imaging with a deep neural network and computational modeling to classify distinct drug-induced nucleolar morphology changes with high accuracy and link them to nucleolar dysfunction. As such, this method can enable high-throughput characterization of nucleolar and other condensate phase behavior changes in chemical or genetic screens, directly linking condensate morphology changes to its physical mechanism of action for the first time.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G06N 3/08 - Learning methods
• G06T 3/4046 - Scaling of whole images or parts thereof, e.g. expanding or contracting using neural networks

Abstract

A system for determining the ripeness of a food product (such as a fruit or vegetable) may include a metamaterials-based sticker configured to be coupled to an outer surface of the food product. The sticker may include micron-scale metal resonators coupled to a base, and may be configured to resonate at a sub-terahertz (THz) frequency. The system may include a handheld device, which may include a receiver configured to receive a reflection spectrum from the sticker after the sticker has been excited by electromagnetic radiation. The receiver may be configured to detect one or more wavelengths having frequencies of around 100 GHz - 170 GHz and 210 - 250 GHz. The system may include processing unit(s) configured to, collectively, perform various steps, including determining a resonant frequency, a dielectric property, a refractive index, or a value representative of the ripeness of the food product based on a reflection spectra.

IPC Classes  ?

• G01N 21/55 - Specular reflectivity
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 33/02 - Food
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements

Abstract

Disclosed is a method for characterizing compositional and functional histories of cellular proteins and their associated molecular complexes in space and time. The method may include forming fusion proteins by fusing a universal genetic tag to each of a plurality of endogenous proteins. The fusion proteins may be conditionally labelled with a first ligand. The first ligand may be a ligand with a developed immunopurification capability and a known imaging capability. The method may include expressing the fusion proteins and performing at least one analysis. The analyses may include (i) tracking the plurality of endogenous proteins and any associated macromolecular complexes; (ii) determining composition and function of the plurality of endogenous proteins and/or any associated macromolecular complexes; and/or (iii) removing a ligand and performing a pulse-chase analysis.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 1/34 - PurifyingCleaning
• G01N 21/64 - FluorescencePhosphorescence
• C07K 19/00 - Hybrid peptides

Abstract

A design methodology and tool called INFORM are provided that use a two-phase approach for sample-efficient constrained multi-objective optimization of real-world nonlinear systems. In the first optional phase, one may modify a genetic algorithm (GA) to make the design process sample-efficient, and may inject candidate solutions into the GA population using inverse design methods. The inverse design techniques may be based on (i) a neural network verifier, (ii) a neural network, and (iii) a Gaussian mixture model. The candidate solutions for the next generation are thus a mix of those generated using crossover/mutation and solutions generated using inverse design. At the end of the first phase, one obtains a set of nondominated solutions. In the second phase, one chooses one or more solution(s) from the non-dominated solutions or another reference solution to further improve the objective function values using inverse design methods.

IPC Classes  ?

• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
• G06F 111/06 - Multi-objective optimisation, e.g. Pareto optimisation using simulated annealing [SA], ant colony algorithms or genetic algorithms [GA]

Abstract

Disclosed are techniques for enhanced nucleic acid detection using blocked or partially blocked crRNAs or target RNAs, and a composition of matter (detection reactions consisting of occluded crRNAs or target RNAs). Here, the mechanism of Cas 13 protein activation in response to RNA structure perturbations was systematically probed using a massively multiplexed screen. It was found that there are two distinct sequence-independent modes by which secondary structure affects Cas13 activity: structure in the protospacer region competes with the crRNA and can be disrupted via a strand-displacement mechanism, while structure in the region 3′ to the protospacer has an allosteric inhibitory effect. The kinetic nature of the strand displacement process was leveraged to improve Cas13-based RNA detection and enhance mismatch discrimination by up to 50-fold, enabling sequence-agnostic mutation identification at low (<1%) allele frequencies.

IPC Classes  ?

• C12Q 1/6823 - Release of bound markers
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/683 - Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
• C12Q 1/6832 - Enhancement of hybridisation reaction

Goods & Services

Stickers and decals Bags Clothing, footwear, and headgear

Goods & Services

Association services, namely, promoting the interests of alumni; arranging, organizing, conducting, and hosting alumni events for business development, business networking, and professional networking purposes; promoting special events of university and alumni groups; charitable services, namely, organizing and conducting volunteer programs and community service projects; administration of a program for alumni to interview university applicants Arranging, organizing, conducting and hosting social entertainment events; organizing and arranging of seminars, discussions, and lectures in the fields of general interest, education, music, art, science, literature, government, social justice, leadership development, sports, and academics; educational services, namely, providing educational speakers and lecturers; providing an interactive website featuring information related to educational, entertainment, athletic and social events for alumni of an educational institution; providing online newsletters featuring articles and information regarding alumni news, alumni achievement, career opportunities, and networking events

Abstract

A process for making liquid fuels, especially diesel fuel, from primary alcohols. The process involves subjecting a feedstock comprising primary alcohols to Guerbet coupling to yield a first intermediate mix; subjecting the first intermediate mix to hydrogenolysis to yield a second intermediate mix; and subjecting the second intermediate mix to etherification to yield a liquid fuel suitable for use in internal combustion engines.

IPC Classes  ?

• F02D 19/06 - Controlling engines characterised by their use of non-liquid fuels, pluralities of fuels, or non-fuel substances added to the combustible mixtures peculiar to engines working with pluralities of fuels, e.g. alternatively with light and heavy fuel oil, other than engines indifferent to the fuel consumed

Abstract

Disclosed are techniques for monoterpenes biosynthesis in engineered microorganisms having a mevalonate pathway, where the microorganisms express an engineered enzyme. The engineered enzyme may include one or more peptides that are selected to alter the active site pocket volume of the engineered enzyme as compared to a wild-type farnesyl pyrophosphate synthase. The engineered enzyme may include a first peptide (such as a linker peptide) fused to a C-terminus of a farnesyl pyrophosphate synthase. Optionally, a second peptide (such as a Myc-tag or a HA-tag) be fused to the first peptide. The method may include exposing the engineered microorganism to a carbon source (such a glucose). The method may include allowing the engineered microorganism to generate (i) a first product from the mevalonate pathway and (ii) the engineered enzyme. The method may include forming a monoterpene by allowing the first product and the engineered enzyme to interact.

IPC Classes  ?

• C12P 5/02 - Preparation of hydrocarbons acyclic
• C07K 14/395 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from fungi from yeasts from Saccharomyces
• C12N 1/16 - YeastsCulture media therefor
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 9/10 - Transferases (2.)

Abstract

Disclosed are a method and system for thermal stabilization of pharmaceutical formulations containing proteins and monoclonal antibodies. The disclosed method of Rapid Room Temperature Aerosol Dehydration (RTAD) provides a scalable system for continuous dehydration of liquid pharmaceutical and biopharmaceutical formulations that provides thermal stabilization of biological drugs by converting liquid drugs into powder form, enabling their transportation, storage and handling at room temperature. The disclosed process can generate sprays/aerosols with droplets that are lOOx smaller (0.2-20 pm ) than existing spray drying technologies and perform dehydration without applying heat, which mitigates the risk of damage of thermolabile biologicals and provides a significant reduction in energy requirements. The technology has demonstrated superiority of tire system over traditional spray drying and freeze drying with respect to energy consumption, biological activity, scalability, powder dissolution, reduced protein aggregation, particle size and size uniformity, and high- quality of produced inhalable and reconstitutable biologic formulations.

IPC Classes  ?

• A61K 9/12 - AerosolsFoams
• B05B 7/24 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
• B05B 9/04 - Spraying apparatus for discharge of liquid or other fluent material without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible containerSpraying apparatus for discharge of liquid or other fluent material without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pump
• F26B 3/12 - Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray
• B05B 7/16 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating the material to be sprayed
• B01D 1/18 - Evaporating by spraying to obtain dry solids
• F26B 21/00 - Arrangements for supplying or controlling air or gases for drying solid materials or objects

Abstract

A process for making liquid fuels, especially diesel fuel, from primary alcohols. The process involves subjecting a feedstock comprising primary alcohols to Guerbet coupling to yield a first intermediate mix; subjecting the first intermediate mix to hydrogenolysis to yield a second intermediate mix; and subjecting the second intermediate mix to etherification to yield a liquid fuel suitable for use in internal combustion engines.

IPC Classes  ?

• C10L 1/02 - Liquid carbonaceous fuels essentially based on components consisting of carbon, hydrogen, and oxygen only
• C07C 2/06 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation of alkenes, i.e. acyclic hydrocarbons having only one carbon-to-carbon double bond
• C07C 37/16 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving hydroxy groups of phenols or alcohols or the ether or mineral ester group derived therefrom
• C07C 41/09 - Preparation of ethers by dehydration of compounds containing hydroxy groups

Abstract

Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.

IPC Classes  ?

• G21B 1/05 - Thermonuclear fusion reactors with magnetic or electric plasma confinement
• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor

Abstract

A synthetic triterpene composition such as squalene and methods for producing the composition by novel chemical synthesis routes is claimed. The squalene produced by the synthetic methods covered in this invention formulation is of high purity suitable for use in making vaccine adjuvants, antioxidant formulations, and drug delivery agents.

IPC Classes  ?

• A61K 31/01 - Hydrocarbons
• A61K 47/06 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
• A61K 39/12 - Viral antigens
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

Abstract

Systems and methods for predicting cell-type-specific gene expression from genetic sequence are described. A computational framework can comprise a computational model for predicting epigenetic regulatory markers using genetic sequence as input. A computational framework can additionally, or alternatively, comprise a computational model for predicting cell-type-specific gene expression utilizing epigenetic regulatory markers spaced along sequence of genes. The computational model for predicting cell-type-specific gene expression can be trained with single-cell genetic expression profiles, such as scRNA-seq or snRNA-seq. The computational framework can be utilized to assess polymorphic sequences, such as polymorphisms related to medical disorders. Various methods further develop research tools, perform diagnostics, and treat individuals based on cell-type-specific gene expression levels, which can be further based on differential gene expression patterns among polymorphic sequences.

IPC Classes  ?

• G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
• G16B 10/00 - ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G16B 20/30 - Detection of binding sites or motifs
• G16B 20/50 - Mutagenesis

Abstract

Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches.

IPC Classes  ?

• H04L 47/11 - Identifying congestion
• H04L 43/062 - Generation of reports related to network traffic
• H04L 43/16 - Threshold monitoring
• H04L 47/125 - Avoiding congestionRecovering from congestion by balancing the load, e.g. traffic engineering
• H04L 47/2483 - Traffic characterised by specific attributes, e.g. priority or QoS involving identification of individual flows
• H04L 47/32 - Flow controlCongestion control by discarding or delaying data units, e.g. packets or frames

Abstract

According to various embodiments, a machine-learning based system for mental health disorder identification and monitoring is disclosed. The system includes one or more processors configured to interact with a plurality of wearable medical sensors (WMSs). The processors are configured to receive physiological data from the WMSs. The processors are further configured to train at least one neural network based on raw physiological data augmented with synthetic data and subjected to a grow-and-prune paradigm to generate at least one mental health disorder inference model. The processors are also configured to output a mental health disorder-based decision by inputting the received physiological data into the generated mental health disorder inference model.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

Abstract

A magnetic orbital angular momentum beam accelerator will accelerate charged particles, electrons or ions, from rest in zero or low magnetic field into a high magnetic field regions with high kinetic energies in the form of magnetic orbital angular momentum. For example, a beam injector that accelerates electrons or ions into 1T magnetic fields with tens of keV kinetic energies transverse to the magnetic fields can be used to heat magnetically confined plasmas, to inject an initial energetic plasma component with high magnetic orbital angular momentum and to produce highly transverse particle momenta to the magnetic field for electron or ion beam lithography.

IPC Classes  ?

• H05H 13/08 - Alternating-gradient magnetic resonance accelerators
• H05H 13/00 - Magnetic resonance acceleratorsCyclotrons

Abstract

Compositions of matter and methods for using the composition of matter may be provided. The method may include providing a virus-like particle (VLP) comprising C. elegans retrotransposon 1 (Cer1) and a heterologous RNA-based agent to an organism and allowing the organism to transfer the heterologous RNA-based agent to a tissue within the organism.

IPC Classes  ?

• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Cas-cleavable reporter systems, CRISPR-Cas systems thereof, and methods of use thereof in CRISPR-Cas based diagnostics. Cas-cleavable reporter systems may generate a luminescent, fluorescent, or other detectable signal upon Cas-collateral cleavage of one or more reporter system components. CRISPR-Cas systems may comprise a Cas protein having collateral cleavage activity, guide molecules, and the Cas-cleavable reporter system. Cas-cleavable reporter systems may be a split luciferase reporter system, at least one element of which is bound to beads. For multiplexing, CRISPR-Cas systems may comprise a Cas-cleavable quenched reporter system, optionally a Cas-cleavable quenched fluorescent reporter system, a Cas protein having collateral cleavage activity, and target-specific guide molecules attached to color-coded beads. CRISPR-Cas systems may further comprise amplification reagents. Methods may apply said CRISPR-Cas systems to flow cell, well-plate, or other devices, and may measure detectable signals by microscopic, plate reader, or other methods.

IPC Classes  ?

• C12Q 1/682 - Signal amplification
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

Disclosed is a technique that enables structural reinforcement and thermal stabilization of the conductor winding in a superconducting coil configuration, and superconducting coils produced via the technique. The superconducting coils generally include coil windings of superconducting materials defining an electrically conductive channel having an inlet and an outlet, where the coil windings are either (i) helically wound around a curve around a central axis or (b) wound in helical layers around a curve around a central axis. One or more of the coil windings are operably coupled to at least one co-wound reinforcement layer, where the at co-wound reinforcement layer(s) are positioned between at least two adjacent superconducting coil windings or layers of superconducting coil windings. The method can significantly improve the packing factor in a coil winding while simplifying quench protection, permitting the construction of all-metal high field magnets with large bore and high magnetic field.

IPC Classes  ?

• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
• G01R 33/3815 - Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using electromagnets with superconducting coils, e.g. power supply therefor
• H01F 6/02 - QuenchingProtection arrangements during quenching
• H01F 41/04 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets for manufacturing coils

Abstract

Disclosed herein are optogenetic circuits for the bacterium Escherichia coli that induce gene expression in darkness and repress it under blue light. Applying them to metabolic engineering improves chemical production compared to chemically induced controls in light-controlled fermentations. More particularly, these circuits can be used to control protein production with light. The system and method use light as a suitable alternative to chemical induction for microbial production of chemicals and proteins.

IPC Classes  ?

• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

Disclosed are methods and a pharmaceutical composition for the prevention and treatment of fibrosis by the inhibition of fibronectin matrix assembly, as well as insights into the molecular mechanism by which cell-mediated assembly of fibronectin (FN) matrix contributes to extracellular matrix (ECM) accumulation. Peptides S2, S3, S20, and variants thereof may be utilized, either alone or fused to one or more proteins. In one aspect, a construct comprising a first protein fused to a first end of a peptide and a second protein fused to a second end of the peptide may be used, where the peptide has at least 80% sequence identity to S2, S3, or S20. The peptide may then be allowed to interact with fibronectin.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C12N 9/10 - Transferases (2.)

Abstract

in situin situ position detection, thickness and refractive index measurement, and/or focus control, are provided. The systems may include a first laser emitting device, a first lens, a first beam splitter and a second lens respectively forming an optical path. The second lens, the first beam splitter, a third lens, and an image detection and processing module (that includes a sensor, such as a photodiode) may form an optical return path. The second lens may be configured to continuously oscillate, as a function of time, a focal position of a laser from the first laser emitting device. The image detection and processing module may be configured to receive a reflected beam, send information related to the received beam to processing units(s), which may be configured to receive the information and determine one or more surface positions based on a temporal response of the information.

IPC Classes  ?

• G01B 11/06 - Measuring arrangements characterised by the use of optical techniques for measuring length, width, or thickness for measuring thickness
• G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length
• G01M 11/02 - Testing optical properties
• G01B 11/02 - Measuring arrangements characterised by the use of optical techniques for measuring length, width, or thickness
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• G01S 7/481 - Constructional features, e.g. arrangements of optical elements

Abstract

Methods for co-designing transformer-accelerator pairs are provided. The methods may include using a transformer embedding to generate a computational graph and a transformer model. The methods may include running the computational graph through a surrogate model and outputting accuracy data of the surrogate model. The methods may include using an accelerator embedding and the transformer model to simulate training and inference tasks and outputting hardware performance data of the transformer model. The methods may include sending the hardware performance data (such as latency, energy leakage, dynamic energy, and chip area, which may be optimizable performance parameters) and model accuracy data to a co-design optimizer. The methods may include generating an output transformer-accelerator or a transformer-edge-device pair from the co-design optimizer. The transformer model and accelerator embedding may be the output transformer-accelerator or a transformer-edge-device pair.

IPC Classes  ?

• G06N 20/00 - Machine learning
• G06N 5/04 - Inference or reasoning models

Abstract

Block copolymer-stabilized nanoparticles (50 nm - 1000 nm in size) of oligonucleotides with a polyethylene glycol (PEG) steric stabilizing layer are provided. Such nanoparticles may be formed using stabilizing blocks of PEG with molecular weights of 1000-5000 Dalton molecular weight, and hydrophobic anchoring blocks of a degradable polylactide and/or degradable lactide-co-glycolide polymer with molecular weights of 1000-20,000 Dalton molecular weight. The anchoring blocks may be, e.g., a polycaprolactone polymer, a polylactic acid polymer, and/or a copolymer of a lactide-co-glycolide polymer. Such nanoparticles are preferably configured to be internalized into cells and transfect cells at least as effectively as a lipid nanoparticle formulated with 1500 Dalton molecular weight PEG and Dimyristoyl glycerol (DMG) anchoring lipids.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 9/14 - Particulate form, e.g. powders
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

Abstract

Disclosed is a method to 3D print materials with defined bacterial communities into controlled, complex 3D structures, and compositions. The technique includes first providing an ink composition that includes a pre-polymer composition and a microorganism, where the pre-polymer composition includes a polymerizable monomer, a cross-linking agent, the photoinitiator, and a solvent. The technique also includes 3D printing a pattern in a hydrogel support matrix using the ink composition where the hydrogel support matrix is in a container. The technique may also include forming a 3D printed engineered living material by curing the 3D printed pattern.

IPC Classes  ?

• B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
• B29C 64/209 - HeadsNozzles
• B29C 64/264 - Arrangements for irradiation
• B29C 64/40 - Structures for supporting 3D objects during manufacture and intended to be sacrificed after completion thereof
• B29K 33/00 - Use of polymers of unsaturated acids or derivatives thereof, as moulding material
• B29K 105/00 - Condition, form or state of moulded material
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• C12N 1/20 - BacteriaCulture media therefor

Abstract

Provided are polynucleotides comprising a transcriptional control element comprising a promoter sequence having at least 80% sequence identity to SEQ ID NO: 1. SEQ ID NO:2. SEQ ID NO:3 or SEQ ID NO:4 and a cell- or tissue-specific enhancer element. Also provided are compositions (e.g., vectors, viruses, host cells, and pharmaceutical compositions) comprising said polynucleotides, methods that are useful for expressing a target gene in a host cell, and methods that are useful for expressing a target gene in a subject in need thereof.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/86 - Viral vectors

Abstract

Systems and methods for fibrous material manufacturing are provided. The methods include dispensing a first stream of a solution (that includes a crosslinkable material) from first nozzle(s) into a bath containing a liquid (that includes a first material). The first nozzle(s) are submerged in the liquid. The methods include dispensing a second stream from second nozzle(s) also submerged in the liquid. The second stream(s) are configured to elongate and thin the first stream(s). The second stream contain a liquid. The liquid includes a second material, which may be the same, or may be different, form the first material. The methods include forming a fibrous material by crosslinking the crosslinkable material in the first stream (e.g., using a light source to cross-link a photo-crosslinkable material in the stream).

IPC Classes  ?

• D01D 5/38 - Formation of filaments, threads, or the like during polymerisation
• D01D 5/06 - Wet spinning methods
• D01F 1/08 - Addition of substances to the spinning solution or to the melt for forming hollow filaments
• D01F 6/36 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from copolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds comprising unsaturated carboxylic acids or unsaturated organic esters as the major constituent

Abstract

Compositions are provided that can be used to, e.g., treat or prevent infections caused by Streptococcus suis. The compositions may include one or more threoglucins in a carrier, at a total concentration of threoglucins being at least 1 μM. The at least one threoglucin may include one or more of threoglucins A-R. Such threoglucins may be produced by, e.g., growing a culture of Streptococcus suis in the presence of niacin, nicotinamide, and/or anabasine.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 31/04 - Antibacterial agents

Abstract

Disclosed herein are methods and devices for generating sprays with droplets of micron and submicron diameter. This is accomplished through the disintegration of a thin liquid film using an atomizing gas flow. The device comprises a nozzle device having at least three channels comprising an inner channel, at least one middle annular channel, outside of the inner channel, and at least one outer annular channel outside of the at least one middle annular channel, the at least one middle annular channel being coaxially arranged between the inner channel and the at least one outer annular channel and having a gap width sufficient so as to atomize a liquid flowing through the at least one middle annular channel upon flow of one or more gases through at least the inner channel and the at least one outer annular channel. The methods comprise use of the device for generating atomized particles.

IPC Classes  ?

• B05B 15/00 - Details of spraying plant or spraying apparatus not otherwise provided forAccessories
• A61M 11/04 - Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
• A61M 11/06 - Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Abstract

The present disclosure relates to prime editing systems, compositions, and methods for altering target gene sequences and/or expression of target gene sequences.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• A61K 38/45 - Transferases (2)
• A61K 38/46 - Hydrolases (3)
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Abstract

Described herein is a method of screening for a nuclease with an altered nuclease activity comprising; a) forming a first compartmentalizing reaction comprising a carrier and a variant nuclease template nucleic acid comprising a coding region for a variant nuclease, and amplifying said coding region for said variant nuclease, to obtain variant nuclease encoding nucleic acid; b) forming a second compartmentalizing reaction comprising said variant nuclease encoding nucleic acid, and performing an in vitro transcription and translation reaction to obtain variant nuclease polypeptides; and c) forming a third compartmentalizing reaction comprising said variant nuclease polypeptides, and assaying said variant nuclease polypeptides for the altered nuclease activity of said nuclease.

IPC Classes  ?

• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase

Abstract

A retroreflector tracking and sensing technique is provided. Systems may include a laser source, optical component(s), and a beam steering component disposed along an optical transmit path. The optical component(s) may be disposed between the laser source and the beam steering component (such as a mirror coupled to an actuator). The systems may include a position-sensitive detector (PSD). The beam steering component, one or more of the optical component(s), and the PSD may be disposed along an optical return path. The optical component(s) in the optical return path may be disposed between the beam steering component and the position-sensitive detector. The PSD may be operably coupled to a position tracking analyzer and an optical sensing analyzer. Electrical signals generated by the PSD may be configured to be used for retroreflector tracking and/or optical sensing.

IPC Classes  ?

• G01S 17/66 - Tracking systems using electromagnetic waves other than radio waves
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01S 7/481 - Constructional features, e.g. arrangements of optical elements

Abstract

Systems and methods are provided for measuring analytes (e.g., greenhouse gases, such as nitrous oxide) in the air over a field or other area. An optical web can be cast over the field, using a laser respectively provided from each of two or more towers disposed around an edge of the field, for the estimation of flux emissions and their spatiotemporal parameters. Each laser can be configured to provide light at a respective predetermined wavelength to one or more reflectors disposed around an edge of the field, providing a path integrated measurement, and then the light returns from the reflector to a detector that is coaligned with each respective laser. By making many such measurements, a set of linear equations can be generated, which can then be used to solve for the emission in any one grid cell of the field.

IPC Classes  ?

• G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01W 1/02 - Instruments for indicating weather conditions by measuring two or more variables, e.g. humidity, pressure, temperature, cloud cover or wind speed

Abstract

Techniques for controlling heat transfer or emission using spectrally selective transmissive substrates are provided. Each spectrally selective transmissive substrate may include a plurality of alternating stacked layers, where the spectrally selective transmissive substrate is generally at least 50% transparent on average across a long wavelength infrared wavelength range (8 pm to 13 pm), and greater than 30% reflective on average across infrared wavelengths outside the long wavelength infrared (LWIR) wavelength range. Such substrates may include polymer such as a polyolefin, a nylon, or a polytetrafluoroethylene (PTFE), and may include air voids with a lower refractive index than polyethylene, and/or particles with a higher refractive index than polyethylene, such as ZnO. ZnS. ZnSe, CuO, FeO, Si, etc. Particles sizes are typically selected to behave as an effective medium in LWIR wavelengths, which are 5-20x larger than the particles, while still providing either solar scattering or solar transparency as desired.

IPC Classes  ?

• F28F 13/18 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by applying coatings, e.g. radiation-absorbing, radiation-reflectingArrangements for modifying heat transfer, e.g. increasing, decreasing by surface treatment, e.g. polishing
• E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshineSimilar screens for privacy or appearance
• B32B 17/10 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like comprising glass as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
• E04B 1/76 - Heat, sound or noise insulation, absorption, or reflectionOther building methods affording favourable thermal or acoustical conditions, e.g. accumulating of heat within walls specifically with respect to heat only

Abstract

In one aspect, compositions and methods are described herein for providing a microenvironment mapping platform operable to selectively identify various features, including in vivo protein-protein interactions on cellular membranes. In some embodiments, a composition comprises a tetrapyrrole photocatalyst, and a protein labeling agent, wherein the tetrapyrrole photocatalyst has electronic structure to activate the protein labeling agent to a reactive intermediate via energy transfer. The reactive intermediate reacts or crosslinks with a protein or other biomolecule within the diffusion radius of the reactive intermediate.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• G01N 33/80 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood groups or blood types

Abstract

Disclosed is a framework called SCouT that employs a Transformer architecture to make counterfactual predictions that can be used in healthcare and other longitudinal decision-making scenarios. The disclosed approach can use longitudinal donors under an intervention to estimate the synthetic counterfactual for other units. The Transformer-based encoder-decoder model uses a causal map, which enables spatial bidirectionality, to autoregressively generate a synthetic control of a target unit.

IPC Classes  ?

• G06N 3/0455 - Auto-encoder networksEncoder-decoder networks

Abstract

A process for water, mineral, and/or organics recovery, as well as devices and systems that practice the process, are disclosed. The process may include providing a plurality of evaporator structures, each structure physically separated from the others, and contacting the first end of each evaporator structure with a liquid containing a plurality of materials (such as a solvent and one or more minerals). The process may include allowing capillary forces and siphonic action to draw at least one material of the plurality of materials (which may be, e.g., the solvent, a volatile organic material, and/or a mineral) from the first end towards the second end, and evaporating one or more of the plurality of materials by transferring at least one form of environmental energy (such as solar energy, wind energy, and/or ambient heat of air) directly to each evaporator structure, thereby providing the latent heat of vaporization.

IPC Classes  ?

• B01D 1/00 - Evaporating
• B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
• B01D 9/00 - Crystallisation
• C01D 3/06 - Preparation by working up brines, seawater or spent lyes
• C01D 15/04 - Halides
• C01D 15/08 - CarbonatesBicarbonates
• C22B 26/12 - Obtaining lithium

Abstract

Systems and methods for tackling a significant problem in data analytics: inaccurate dataset labeling. Such inaccuracies can compromise machine learning model performance. To counter this, label error detection algorithm is provided that efficiently identifies and removes samples with corrupted labels. The provided framework (CTRL) detects label errors in two steps based on the observation that models learn clean and noisy labels in different ways. First, one trains a neural network using the noisy training dataset and obtains the loss curve for each sample. Then, one applies clustering algorithms to the training losses to group samples into two categories: cleanly-labeled and noisily-labeled. After label error detection, one removes samples with noisy labels and retrains the model.

IPC Classes  ?

• G06N 3/08 - Learning methods

Abstract

A light emitting device comprises a waveguide, a downconverting thin-film stack in optical communication with the waveguide, and an OLED thin-film stack in optical communication with the downconverting thin-film stack. An integrated photonic system comprises the downconverted as described above, wherein the downconverted OLED stack is integrated with a silicon photonic chip or CMOS photonic chip. A method for providing pump light for a silicon photonic integrated circuit comprises providing the integrated photonic as described above, producing light via the OLED thin-film stack; downconverting the produced light via the downconverting thin-film stack, and guiding the downconverted light via the waveguide.

IPC Classes  ?

• G02B 6/42 - Coupling light guides with opto-electronic elements

Goods & Services

Educational services, namely, providing instruction and training at the undergraduate, graduate and post graduate levels

Abstract

Compositions including dihydromyricetin (DHM) and methods for forming them through spray drying.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A reactant comprising one or more polymers can be subjected to multiple consecutive processing cycles. Each processing cycle can have a first period with heating applied and a second period immediately following the first period with no heating applied. A duration of each processing cycle can be less than or equal to 10 seconds, and a duration of each first period can be less than 1 second. The subjecting can be effective to convert at least some of the reactant into one or more products, for example, one or more constituent monomers or other volatile or gas-phase species. In some embodiments, a reactor can be provided between a heating source and the reactant, for example, to provide a spatio-temporal temperature profile for improved polymer processing.

IPC Classes  ?

• C08J 11/12 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by dry-heat treatment only
• B01J 6/00 - CalciningFusing

Abstract

A base station classifier on a portable device includes code for obtaining base station resource allocations, converting the allocations into vectors to provide input to a neural network, and providing access to a trained neural network that evaluates the vectors to identify that a base station is a trusted vendor base station. A method of operations listens to resource allocations of a connected device, converts each allocation into a vector suitable for neural network analysis, evaluates the vector with a trained neural network with to determine if the vector is from a trusted base station, and connects only to base stations indicated by the trained neural network to be a trusted base station.

IPC Classes  ?

• H04L 41/16 - Arrangements for maintenance, administration or management of data switching networks, e.g. of packet switching networks using machine learning or artificial intelligence
• H04W 12/12 - Detection or prevention of fraud
• H04W 72/04 - Wireless resource allocation
• G06F 21/00 - Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity