Disclosed herein is a live navigation tool. A scan of a sample is generated based on a first channel. The scan of the sample is acquired at a first magnification. Data relating to a camera feed of an imaging device during imaging of the sample is received from the imaging device. The data is received in real time. The camera feed is associated with at least one of a second magnification and a second channel. The second magnification is different from the first magnification and/or the second channel is different from the first channel. The scan and a window are displayed via an interface of a computing device. The camera feed of the imaging device is displayed in the window.
Disclosed herein is a focusing stage. The focusing stage comprises a unit configured to perform real-time focus correction during imaging of a sample. The sample is contained by a substrate positioned on a sample stage. The unit comprises a multi-spot light module comprising a plurality of stationary light sources, at least one optical light splitter configured to reflect a portion of light projected by at least one first stationary light source of the plurality of stationary light sources, at least one detector configured to detect spots of light reflected from interfaces of the substrate, a detector processor configured to calculate, based on locations of the spots on the at least one detector, a correction of a distance between a first objective lens of a plurality of objective lenses and the substrate, and an actuator configured to adjust the distance between the first objective lens and the substrate by the correction.
Described herein is a tissue sample compartmentalization apparatus and methods for labeling and identifying one or more analytes in a tissue sample. In one embodiment the apparatus comprises a tissue sample compartmentalization module having a first member defining a first plurality of apertures; and a second member defining a second plurality of apertures, the second member pivotably connected to the first member, wherein the second member is configured to engage with the first member to form a closed configuration or pivot relative to the first member between an open configuration and a closed configuration, wherein in the closed configuration the first plurality of apertures and the second plurality of apertures are aligned and form a plurality of sample compartments. The tissue sample compartmentalization module permits individual sample environments for sectioned tissue microscope slides.
The electronic pipette comprises at least one cylinder (11), a piston (12) protruding into said at least one cylinder (11) and configured to be moveable in a reciprocating manner for aspirating liquid into the pipette and dispensing liquid from the pipette, a motor (13) for moving the piston (12), and a control system (30) for controlling the operation of the pipette, wherein the control system (30) is configured to monitor the counter-electromotive force of the motor (13).
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
Inventor
Hadfield, Maximillian Spencer
Abstract
Methods and systems for scientific method creation. One method includes building a data store including a plurality of linked data sets linking a predetermined experiment method defining a plurality of experiment parameters, a predetermined sample type, and a predetermined analysis; training a model with the plurality of linked data set stored in the data store; inputting to the model, as trained, at least one selected from a group consisting of a sample type and a desired analysis; and outputting, from the model, a list of one or more recommended methods based on the at least one of the sample and the desired analysis. The method may also include receiving actual experiment results collected via one or more scientific instructions, the actual experiment results associated with performance of a method from the list; determining expected results for the performed methods; and verifying the actual experiment results based on expected results.
Thermo Electron Manufacturing Limited (United Kingdom)
Inventor
Hadfield, Max
Abstract
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a method is provided that includes generating a sample identifier for a sample, receiving sample information for the sample, and generating a data structure ledger for the sample. The data structure ledger includes an initial ledger block with the sample identifier and the sample information. The method also includes receiving experiment data relating to the sample, generating an experiment ledger block in the data structure ledger. The method further includes receiving a request for a report corresponding to the sample, querying the data structure ledger to receive ledger data corresponding to the request, and generating the report based on the ledger data received in response to the query.
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
Inventor
Williams, Richard Thomas
Cui, Xiao
Abstract
The present invention relates to column packing material and methods of making thereof. In particular, the present invention relates to column packing material that is used in Hydrophilic Interaction Liquid Chromatography (HILIC).
B01D 15/08 - Selective adsorption, e.g. chromatography
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
B01D 15/10 - Selective adsorption, e.g. chromatography characterised by constructional or operational features
The charging stand kit for assembling a charging stand (1) for electrical pipettes (10) comprises a charging module (2) configured to hold an electrical pipette (10) to be charged, the charging module (2) comprising first and second sets of electrical contacts (7, 8) on first and second sides for connecting the charging module (2) electrically to adjacent parts (2, 3) of the charging stand (1), a first leg (3) having an upper end con- figured to be attached to the first side of the charging module (2) and comprising a set of electrical contacts (9) configured to contact the first set of electrical contacts (7) of the charging module (2), and a second leg (4) having an upper end config- ured to be attached to the second side of the charging module (2).
The charging stand (1) for electrical pipettes (10) comprises a base (6), at least one leg (3, 4) extending upwards from the base (6), a charging position (25, 25') arranged at the upper end of the charging stand (1) and configured to receive an electrical pipette (10) and comprising means (11) for supplying charging current to said electrical pipette (10), and a temporary storage position (26, 26') configured to receive said electrical pipette (10) such that in the temporary storage position (26, 26') the pipette (10) is in a higher vertical position than in the charging position (25, 25'). The charging stand (1 ) is configured such that in the charging position (25, 25') the electrical pipette (10) is supported from a first height of the pipette (10) and in the temporary storage position the electrical pipette (10) is supported from a second height of the pipette (10), the second height being below the first height.
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
DIONEX CORPORATION (USA)
Inventor
Hadfield, Maximillian Spencer
Schroeder, Tara L.
Lin, Linda Xueying
Rehman, Misbah
Cao, Yu
Cardasis, Helene L.
Zhou, Yu
Kenny, Patrick
Yuen, Waiming
Schauer, Kevin
Abstract
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a support system is provided for a scientific instrument. The support system is configured to acquire, for each of a plurality of scientific instrument groups, asset information associated with the scientific instrument group. The scientific instrument group includes at least one scientific instrument. The support system is also configured to acquire, for each of the plurality of scientific instrument groups, reservation information associated with the scientific instrument group. The support system is also configured to generate, for each of the plurality of scientific instrument groups, a status card including status information associated with the scientific instrument group. The status information is at least based on the asset information and the reservation information. The support system is configured to provide a first user interface for displaying the status cards.
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
THERMO FINNIGAN LLC (USA)
DIONEX CORPORATION (USA)
Inventor
Hadfield, Maximillian
Schroeder, Tara
Lin, Linda
Rehman, Misbah
Cao, Yu
Cardasis, Helene
Zhou, Yu
Yuen, Waiming
Kenny, Patrick
Schauer, Kevin
Abstract
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a support system is provided for a scientific instrument. The support system is configured to acquire, for each of a plurality of scientific instrument groups, asset information associated with the scientific instrument group. The scientific instrument group includes at least one scientific instrument. The support system is also configured to acquire, for each of the plurality of scientific instrument groups, reservation information associated with the scientific instrument group. The support system is also configured to generate, for each of the plurality of scientific instrument groups, a status card including status information associated with the scientific instrument group. The status information is at least based on the asset information and the reservation information. The support system is configured to provide a first user interface for displaying the status cards.
According to an example aspect of the present invention, there is provided a method for moving specimen carriers (5) on a cadence deviator, the deviator comprising a deviator disc (11) and at least one entry (15, 16, 17) to the deviator disc (11) and two exits (18, 19, 20) from it, the deviator disc (11) having at least one slot (13) for receiving a specimen carrier (5) from an entry (15, 16, 17) and expelling it to an exit (18, 19, 20), and a control logic (49). The method comprising the steps of rotating the deviator disc (11) at a continuous motion, reading RFID data of the identifying the specimen carrier (5) at before arrival of the specimen carrier (5) to the entry (15, 16, 179 and instructing the deviator control logic (49) on which slot (13) of the deviator disc (11) the specimen carrier (5) has been inserted. Further, the deviator control logic (49) is instructed on which exit (18, 19, 20) the specimen carrier (5) is expelled from the deviator disc (11) and providing the expelling of the specimen carrier (5) at the instructed exit (18, 19, 20) by determining when the slot (13) with the specimen carrier (5) enters the instructed exit (18, 19, 20) on basis of the angular position of the deviator disc (11).
B65G 47/84 - Star-shaped wheels or devices having endless travelling belts or chains, the wheels or devices being equipped with article-engaging elements
According to a first aspect of the present disclosure, there is provided a turning device featuring a guide forming a path, and a set of at least three conveying platforms arranged below and successively along the path. The turning device further includes a first and a third conveying platform having a first rotating direction and a second conveying platform having a direction opposite to the first rotating direction.
B65G 35/06 - Mechanical conveyors not otherwise provided for comprising a load-carrier moving along a path, e.g. a closed path, and adapted to be engaged by any one of a series of traction elements spaced along the path
B65G 47/74 - Feeding, transfer, or discharging devices of particular kinds or types
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
Inventor
Marriott, Philip
Makarov, Alexander
Wapelhorst, Eric
Abstract
An ion optical device comprises: first and second electrode arrangements, spatially separated from one another, for receiving ions and a gas and arranged to operate in a high gas pressure environment; and an RF voltage supply applying: a first RF voltage comprising one or more RF drive frequencies to the first electrode arrangement; and a second RF voltage of the one or more RF drive frequencies, having a different phase, to the second electrode arrangement, wherein the first and second RF voltages have an asymmetric waveform, the application of the first and second RF voltages to the first and second electrodes arrangements respectively causing the received ions to experience an electric field. The first and second electrode arrangements and the RF voltage supply are configured such that a strength of the electric field experienced by the received ions is sufficient for ions to experience mobility variation.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/06 - Electron- or ion-optical arrangements
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
Inventor
Marriott, Philip
Makarov, Alexander
Wapelhorst, Eric
Abstract
An ion repulsive surface comprises: a first plurality of elongated electrodes distributed along an axis, configured to receive a first RF voltage with an asymmetric waveform; and a second plurality of elongated electrodes distributed along the axis, the second plurality of electrodes being interleaved with the first plurality of electrodes and configured to receive a second RF voltage with an asymmetric waveform, having a different phase than the first RF voltage. The first and second pluralities of electrodes and first and second RF voltages are configured such that a strength of an electric field adjacent the ion repulsive surface is sufficient for ions to experience mobility variation. An ion optical device may be provided from such an ion repulsive surface, from which an ion optical system, ion optical interface, mass spectrometer and/or ion mobility spectrometer may be considered.
The tool (1) for removing a cap strip (12) from a row (11) of sample wells (10a) of a tube strip or a microplate (10) com- prises a first wedge portion (2a) having a leading end and be- ing configured to be inserted below an edge of the cap strip (12) on a first side of the row (11) of sample wells (10a), and a second wedge portion (3a) having a leading end and being configured to be inserted below an edge of the cap strip (12) on a second side of the row (11) of sample wells (10a), the thickness of each of the wedge portions (2a, 2b) increasing from the leading end towards another end such that when the tool (1) is moved along the row (11) of sample wells (10a), the wedge portions (2a, 3a) urge the cap strip (12) upwards for releasing the cap strip (12) from the row (11) of sample wells (10a).
Mass Spectrometry has been widely used to identify microbes present in a sample. However, rapid analysis (e.g. 1-5 minutes) of spectral data to identify microbes has proven to be very challenging due to the high level of processing required and complexity associated with identification from a large pool of candidate microbes. Disclosed herein are methods and systems for rapidly identifying microbes present in a sample through the application of conditional likelihoods that certain proteoforms are particularly indicative of a candidate microbe.
The cutting tool (1) for cutting tube strips (2) comprising two or more sample vessels (2a) comprises a body (3), tube strip holding means (4, 5) comprising a first holding portion (4) configured to hold a sample vessel (2a) and a second holding portion (5) configured to hold another sample vessel (2a), a blade unit (6) comprising a blade (11), the blade unit (6) being configured to be moveable in a direction that is perpendicular to the longitudinal direction of a tube strip (2) hold by the tube strip holding means (4, 5) and to cut the tube strip (2) between the first holding portion (4) and the second holding portion (5), a lever (7) pivotably connected to the body (3) via a pivot axis (8), and a connecting element (9) connecting the lever (7) to the blade unit (6), wherein rotation of the lever (7) about the pivot axis (8) is configured to move the blade unit (6) towards the tube strip holding means (4, 5) to cut the tube strip (2).
B26D 1/08 - Cutting through work characterised by the nature or movement of the cutting memberApparatus or machines thereforCutting members therefor involving a cutting member which does not travel with the work having a linearly-movable cutting member wherein the cutting member reciprocates of the guillotine type
Thermo Electron Manufacturing Limited (United Kingdom)
Inventor
Marriott, Philip
Abstract
A method of separating a sample of ions according to their ion mobilities is provided. The method comprises receiving the sample of ions into a drift tube; applying a first electric field component within the drift tube so as to cause the sample of ions to move along a path within the drift tube, whereby the sample of ions separates along the path; and applying a second electric field component within the drift tube. The first and second electric field components have a combined electric field strength to modify the ion mobility of at least a portion of the sample of ions and to increase the separation of at least a portion of the sample of ions along the path The second electric field component substantially does not cause a net change in the velocity of the sample of ions perpendicular to the path. An apparatus for separating a sample of ions according to their ion mobilities is also provided.
According to a first aspect of the present disclosure, there is provided a turning device (100) featuring a guide (111) forming a path (113), and a set of at least three conveying platforms arranged below and successively along the path (113). The turning device further includes a first and a third conveying platform (114, 116) having a first rotating direction and a second conveying platform (115) having a direction opposite to the first rotating direction.
B65G 35/06 - Mechanical conveyors not otherwise provided for comprising a load-carrier moving along a path, e.g. a closed path, and adapted to be engaged by any one of a series of traction elements spaced along the path
B65G 47/74 - Feeding, transfer, or discharging devices of particular kinds or types
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
THERMO FISHER SCIENTIFIC (BREMEN) GMBH (Germany)
Inventor
Marriott, Philip
Makarov, Alexander
Wapelhorst, Eric
Abstract
An ion repulsive surface, comprises: a first plurality of elongated electrodes distributed along an axis, configured to receive a first RF voltage with an asymmetric waveform; and a second plurality of elongated electrodes distributed along the axis, the second plurality of electrodes being interleaved with the first plurality of electrodes and configured to receive a second RF voltage with an asymmetric waveform, having a different phase than the first RF voltage. The first and second plurality of electrodes and first and second RF voltages are configured such that a strength of an electric field adjacent the ion repulsive surface is sufficient for ions to experience mobility variation. An ion optical device may be provided from such an ion repulsive surface, from which an ion optical system, ion optical interface, mass spectrometer and/or ion mobility spectrometer may be considered.
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
Inventor
Marriott, Philip
Abstract
A multipole ion optical device comprises: a first plurality of electrodes distributed along a first axis; and a second plurality of electrodes distributed along a second axis, generally parallel to the first axis, to define an ion channel between the first and second pluralities of electrodes. Each of the first plurality of electrodes and the second plurality of electrodes is configured to receive a respective RF voltage having an asymmetric waveform and such that adjacent electrodes of the first and second pluralities of electrodes receive RF voltages having different phases. The first and second plurality of electrodes and the plurality of RF voltages are configured such that a strength of an electric field in the ion channel is sufficient for ions to experience mobility variation.
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
THERMO FISHER SCIENTIFIC (BREMEN) GMBH (Germany)
Inventor
Marriott, Philip
Makarov, Alexander
Wapelhorst, Eric
Abstract
An ion optical device comprises: first and second electrode arrangements, spatially separated from one another, for receiving ions and a gas and arranged to operate in a high gas pressure environment; and an RF voltage supply applying: a first RF voltage comprising one or more RF drive frequencies to the first electrode arrangement; and a second RF voltage of the one or more RF drive frequencies, having a different phase, to the second electrode arrangement, wherein the first and second RF voltages have an asymmetric waveform, the application of the first and second RF voltages to the first and second electrodes arrangements respectively causing the received ions to experience an electric field. The first and second electrode arrangements and the RF voltage supply are configured such that a strength of the electric field experienced by the received ions is sufficient for ions to experience mobility variation.
Mass Spectrometry has been widely used to identify microbes present in a sample. However, rapid analysis (e.g. 1-5 minutes) of spectral data to identify microbes has proven to be very challenging due to the high level of processing required and complexity associated with identification from a large pool of candidate microbes. Disclosed herein are methods and systems for rapidly identifying microbes present in a sample through the application of conditional likelihoods that certain proteoforms are particularly indicative of a candidate microbe.
A filter sampling tool for filtering biological suspensions includes a body having a throughway extending through the body between a first end and an opposing second end, the body including a tubular sleeve portion having a first end and an opposing second end with a first passage extending therebetween, the first end of the tubular sleeve portion forming an opening that communicates with the first passage, the first passage forming at least a portion of the throughway of the body. An elongated stem has a first end and an opposing second end, the first end of the stem terminating at a tip, the stem being retained within the throughway of the body so that the first end of the stem passes through the opening at the first end of the tubular sleeve portion. A first fluid channel is formed between the stem and the body along a length of the stem disposed within the throughway so that fluid entering the body through the opening at the first end of the sleeve portion can travel along the first fluid channel and exit the body at the second end of the body.
The direct identification of antibiotic resistance proteins from clinical specimens remains a challenge. Disclosed herein are unique compositions and methods for overcoming the challenges presented by confounding proteins in positive blood cultures. The disclosed compositions and methods are especially applicable to mass spectrometric based analyses for the identification of microorganisms in a blood culture.
According to the present invention, there is provided an analyser comprising an interface for receiving a cartridge (3) comprising one or more liquid chromatography column(s) (4, 5) and connecting it to the analyser for performing an analysing task, a heater (11) for heating a chromatography column (5, 6), the cartridge (3) comprising a cartridge casing (6) for containment of the liquid chromatography column (4, 5), a heating block (7) thermally connected to the liquid chromatography column (5) and a thermal interface (8) for thermally connecting the heating block (7) to the heater (11).
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory magnetic particle processors for purification of
biological materials; laboratory purification apparatuses
for laboratory use, namely, magnetic particle processors for
purification; computer software and computer programs for
laboratory magnetic particle processors for purification of
biological materials and laboratory purification apparatuses
for laboratory use.
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
Inventor
Marriott, Philip
Abstract
A method of separating a sample of ions according to their ion mobilities is provided. The method comprises receiving the sample of ions into a drift tube; applying a first electric field component within the drift tube so as to cause the sample of ions to move along a path within the drift tube, whereby the sample of ions separates along the path; and applying a second electric field component within the drift tube. The first and second electric field components have a combined electric field strength to modify the ion mobility of at least a portion of the sample of ions and to increase the separation of at least a portion of the sample of ions along the path The second electric field component substantially does not cause a net change in the velocity of the sample of ions perpendicular to the path. An apparatus for separating a sample of ions according to their ion mobilities is also provided.
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Laboratory magnetic particle processors for purification of biological materials; laboratory purification apparatuses for laboratory use, namely, magnetic particle processors for purification; computer software and computer programs for laboratory magnetic particle processors for purification of biological materials and laboratory purification apparatuses for laboratory use.
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory magnetic particle processors for purification of
biological materials; laboratory purification apparatuses
for laboratory use, namely, magnetic particle processors for
purification; downloadable computer software and computer
programs for laboratory magnetic particle processors for
purification of biological materials and laboratory
purification apparatuses for laboratory use.
35.
MASS SPECTROMETRIC METHODS AND COMPOSITIONS FOR IDENTIFYING MICROBES FROM BLOOD BY REDUCING CONFOUNDING PROTEINS
The direct identification of microorganisms from positive blood culture broths by protein analysis remains a challenge. Although positive blood culture broths are usually mono-bacterial or mono-fungal, the presence of proteins from red cells, white cells, and serum confounds analysis. Disclosed herein are unique compositions and methods for overcoming the challenges presented by confounding proteins in positive blood cultures. The disclosed compositions and methods are especially applicable to mass spectrometric based analyses for the identification of microorganisms in a blood culture.
The optical reader for analyzing biological samples comprises a reading plane (3) for receiving a microplate (1), an illuminating arrangement (4) configured to illuminate samples in the wells (2) of the microplate (1), an imaging device (6) arranged to receive light from the microplate (1), a beam splitter (7), which is arranged to direct light from the illuminating arrangement (4) towards the reading plane (3) and to direct light received from the microplate (1) to the imaging device (6), and a lens system (8) arranged between the beam splitter (7) and the reading plane (3) to focus the light received from the illuminating arrangement (4) to a sample and to focus an image of the sample to the imaging device (6). The optical reader is configured to transmit from the illuminating arrangement (4) to the lens system (8) only light having a specific polarization, and the optical reader comprises a polarizer (10, 19) that is arranged between the lens system (8) and the imaging device (6) and configured to block polarized light reflected from the surfaces of the lens system (8).
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
The method of analyzing samples (3) in the wells (2) of a microplate (1) comprises the steps of producing electro- magnetic radiation having a first predetermined wavelength or wavelength range (101), illuminating a sample (3) by said radiation by transmitting the radiation to the sample (3) from above the microplate (1) via the upper end of the well (102), transmitting light emitted by the sample (3) and having a second predetermined wavelength or wavelength range via the upper end of the well (2) to detection means (13) (103), determining intensity of light emitted by one or more predetermined measurement areas (23) of the sample (3) (104), based on the determined intensities, determining a result value representing the total amount of light emitted by the sample (3), and counting the number of spots emitting light having the second predetermined wavelength or wave- length range (106).
A receptacle holder having a base body, a first perimeter wall which at least partially protrudes from the base body, and a plurality of resilient elements, which are distributed about a first axis of the receptacle holder and are detachably connected with the first perimeter wall, and wherein each resilient element comprises a first end portion and a second end portion, and wherein each second end portion rests hooked over an edge of a portion of the first perimeter wall, and wherein the receptacle holder is configured to allow sliding of each second end portion in a direction perpendicular to the first axis.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
A novel waste bin carrier (100) is proposed for carrying at least one waste bin (200). The waste bin carrier (100) includes a frame (110) having a base (130) for receiving thereon one waste bin (200) or more. The waste bin carrier (100) also has a locking mechanism (120) movably attached to the frame (110) for releasably securing at least one waste bin (200) to the waste bin carrier (100). The locking mechanism (120) has a pusher guide (121) that extends in a first horizontal Cartesian dimension (X) for lateral engagement with the waste bin (200). The locking mechanism also has at least one articulated arm (122) that connects the pusher guide (121) to the frame (110) of the waste bin carrier (100) for allowing movement of the pusher guide (121) in respect to the frame (110) between the deployed state and the released state.
B62B 3/04 - Hand carts having more than one axis carrying transport wheelsSteering devices thereforEquipment therefor involving means for grappling or securing in place objects to be carriedLoad handling equipment
B62B 3/10 - Hand carts having more than one axis carrying transport wheelsSteering devices thereforEquipment therefor characterised by supports specially adapted to objects of definite shape
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory equipment for clinical use, namely, a modular,
scalable system comprised of microprocessor-based hardware
and recorded embedded software for laboratory automation and
consolidation of multiple functions, namely, for
consolidating sample transfer, preparation, labeling,
sorting and storage.
The present invention includes a novel method and system for identification of microorganisms in samples that proteins and other biological material from non-microorganism sources (e.g., proteins of mammalian origin) that can interfere with identification of the microorganisms. The methods and systems described herein include use of a single-use chromatography medium to purify intact proteins prior to mass spectrometry analysis. The chromatography medium and the methods described herein can rapidly and efficiently remove of a substantial portion of interfering biological material (e.g., mammalian proteins) from a crude cell lysate while preserving high signal strength and removing enough of the interfering protein(s) to allow for identification of the microorganism(s) by mass spectrometry analysis.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Laboratory equipment used in specimen preparation, namely,
tissue processors for preserving tissues for scientific and
clinical research. Medical apparatus used in specimen preparation, namely,
tissue processors for preserving tissues for medical
diagnostic use.
47.
TISSUE PROCESSING APPARATUS FOR PROCESSING BIOLOGICAL TISSUE
A tissue processing apparatus for processing biological tissue. The tissue processing apparatus includes: an extraction device configured to, when connected to a reagent receptacle, take reagent out from the reagent receptacle for use by the tissue processing apparatus; a tag reader configured to read information from a machine- readable tag. The tissue processing apparatus is configured to: provide an indication to a user to instruct the user to connect the extraction device to a reagent receptacle containing reagent that has not previously been used in a tissue processing apparatus; and after the user has connected the extraction device to a reagent receptacle and/or has indicated that such a connection has been made, use the extraction device to take reagent out from the reagent receptacle for use by the tissue processing apparatus only if it has been determined, based on information read by the tag reader from a machine-readable tag attached to the reagent receptacle, that the reagent receptacle contains reagent that has not previously been used in a tissue processing apparatus.
A pipette comprising a cylinder with a piston movable inside the cylinder for aspiring and dispensing liquid, and a handle portion for gripping the pipette, wherein the pipette further comprises an imaging device element for obtaining images that assist the use of the pipette.
The method of analyzing one or more samples (3) arranged in sample receptacles (2) of a platform (1) that is configured to receive a plurality of separate samples (3) comprises the steps of measuring electromagnetic radiation transmitted or emitted by each sample (3) (201), repeating the measurement a plurality of times at predetermined intervals (202), on the basis of each measurement, forming a result matrix comprising a plurality of cells (23), each cell (23) of the result matrix corresponding to a sample receptacle (2) of the platform (1), wherein a measurement value of each sample (3) is used as an input for determining the visual properties of the respective cell (23) in the result matrix (203), and displaying the results as consecutive matrixes in respect of time (204).
The method of analyzing absorbance of one or more liquid samples (3) arranged in the wells (2) of a microplate (1) comprises the steps of setting a desired wavelength falling within the wavelength range of 380 nm - 750 nm for absorbance measurement (101), illuminating the samples (3) using electromagnetic radiation having a bandwidth of at most 20 nm around the set wavelength (102), measuring radiant flux transmitted through each sample (3) (103), on the basis of measured radiant flux values, determining an absorbance value for each sample (3) (104), and visualizing the absorbance values on a display (12) as a matrix comprising a plurality of cells (23), each cell (23) corresponding to a well (2) of the microplate (1) (105). The set wavelength is used as an input for determining the visual properties of the cells (23).
A method of multiplexing the operation of a sample preparation and analysis system is disclosed. The system includes a sample preparation system capable of preparing a first sample in accordance with a first assay that is selected from a database containing a plurality of unique assays and preparing a second sample in accordance with a second, different assay. The method includes separately transporting the first and second prepared samples to an analysis station having first and second separation channels and an analyzer comprising a mass spectrometer. The method further includes simultaneously analyzing the first prepared sample with the analyzer in accordance with the first selected assay and separating the second prepared sample with the second separation channel in accordance with the second selected assay.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/00 - Particle spectrometers or separator tubes
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
According to an example aspect of the present invention, there is provided a receptacle holder (1) comprising a base body (3), a first perimeter wall (4) which at least partially protrudes from the base body (3), and a plurality of resilient elements (5), which are distributed about a first axis (A1) of the receptacle holder (1) and are detachably connected with the first perimeter wall (4), and wherein each resilient element (5) comprises a first end portion (6) and a second end portion (7), and wherein each second end portion (7) rests hooked over an edge of a portion of the first perimeter wall (4), and wherein the receptacle holder (1) is configured to allow sliding of each second end portion (7) in a direction perpendicular to the first axis (A1).
According to an example aspect of the present invention, there is provided a receptacle terminal (1) comprising a housing (2), and a first transporting unit (3) which is configured to transport at least a first receptacle rack (4), which is arranged on a movable platform (9), within the housing (2) from a first position (5) to a second position (6), and wherein the first receptacle rack (4) is at the second position (6) within the housing (2) and manually accessible by a user through a first opening (7) in the housing (2).
A novel waste bin carrier (100) is proposed for carrying at least one waste bin (200). The waste bin carrier (100) includes a frame (110) having a base (130) for receiving thereon one waste bin (200) or more. The waste bin carrier (100) also has a locking mechanism (120) movably attached to the frame (110) for releasably securing at least one waste bin (200) to the waste bin carrier (100).The locking mechanism (120) has a pusher guide (121) that extends in a first horizontal Cartesian dimension (X) for lateral engagement with the waste bin (200).The locking mechanism also has at least one articulated arm (122) that connects the pusher guide (121) to the frame (110) of the waste bin carrier (100) for allowing movement of the pusher guide (121) in respect to the frame (110) between the deployed state and the released state.
B62B 3/04 - Hand carts having more than one axis carrying transport wheelsSteering devices thereforEquipment therefor involving means for grappling or securing in place objects to be carriedLoad handling equipment
B62B 3/10 - Hand carts having more than one axis carrying transport wheelsSteering devices thereforEquipment therefor characterised by supports specially adapted to objects of definite shape
According to an example aspect of the present invention, there is provided a system (1) for disposal of a series of receptacles (2a, 2b), the system (1) comprising at least one transporting unit (3a, 3b) which is configured to transport a series of receptacles (2a, 2b) to at least one disposal port(4a, 4b) provided for the disposal of the receptacles (2a, 2b), wherein the disposal port(4a, 4b) comprises at least a first disposal guide(5a) connected to a first disposal hole (6a) and a second disposal guide(5b) connected toa second disposal hole (6b), at least one receptacle disposal container (7a, 7b), and wherein the system (1) is configured to guide a first receptacle(2a) to the at least one receptacle disposal container (7a, 7b) via the first disposal guide(5a) and to guide a second receptacle(2b) to the at least one receptacle disposal container (7a, 7b) via the second disposal guide(5b).
A gripper comprising an actuator and two fingers mounted parallel at a distance from each other on the actuator for movement perpendicularly to a longitudinal axis of the fingers, the fingers having a longitudinal body attached at one end to the actuator. The fingers having two longitudinal claws at the end opposite to the end attached to the actuator, the claws being spaced apart so that there is an elongated gap between the claws. At least one of the fingers having a groove for accommodating an optical fiber which extends partially into the elongated gap.
An apparatus for pretreatment of a desired sample in a discrete fluid analyzing instrument includes a frame rotatably mounted on or within the discrete fluid analyzing instrument with a column for immobilizing at least one substance or analyte from the sample. The substance or analyte is reversibly immobilized. A first fluid transport line is provided for aspirating the sample into the column and for ejecting the substance or analyte eluted from the column. A pump is provided for pumping the sample through the column with a second fluid transport line connecting the pump to the column. A member is providing to supply the eluted substance or analyte to the discrete fluid analyzing instrument for measurement of at least one property of the substance or analyte. A device is provided for simultaneously or consecutively directing any non-pretreated sample or any subsample directly to the discrete fluid analyzing instrument.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
An apparatus for pretreatment of a sample of whole blood in a discrete fluid analyzing instrument comprises automated means for handling and analyzing the sample and means for performing a pretreatment step on the sample or a sub-sample of the sample. The means for pretreatment are used for immobilizing at least one substance or analyte from the sample or sub-sample wherein the substance or analyte is reversibly immobilized. Usually, the apparatus further comprises means for eluting the substance or analyte from the capture means prior to analysis.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
A sample vessel (1, 11) for transferring and analyzing a sample with analyzer instrument, which sample vessel comprises an elongated vessel body (2, 12) for containing the sample and a hinged cap (3, 13) connected in top end area of the vessel body, and the cross-section of the vessel body (2, 12) on a transversal plane in relation to the lengthwise center axis of the vessel body the inner surface of the vessel body is rotationally asymmetrical in relation to the lengthwise center axis, wherein the sample vessel (1, 11) comprises a surface (5, 15) extending upwards from the vessel body, which surface partially surrounds the edge of the cap (3, 13), when the cap is in closed position.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
B65D 47/00 - Closures with filling and discharging, or with discharging, devices
B65D 41/18 - Snap-on caps or cap-like covers non-metallic, e.g. made of paper or plastics
B65D 47/08 - Closures with discharging devices other than pumps with pouring spouts or tubesClosures with discharging devices other than pumps with discharge nozzles or passages having articulated or hinged closures
B65D 47/40 - Closures with filling and discharging, or with discharging, devices with drip catchers or drip-preventing means
61.
MASS SPECTROMETRIC METHODS AND KITS TO IDENTIFY A MICROORGANISM
The present invention includes a novel method and system for identification of microorganisms in samples that proteins and other biological material from non-microorganism sources (e.g., proteins of mammalian origin) that can interfere with identification of the microorganisms. The methods and systems described herein include use of a single-use chromatography medium to purify intact proteins prior to mass spectrometry analysis. The chromatography medium and the methods described herein can rapidly and efficiently remove of a substantial portion of interfering biological material (e.g., mammalian proteins) from a crude cell lysate while preserving high signal strength and removing enough of the interfering protein(s) to allow for identification of the microorganism(s) by mass spectrometry analysis.
A sample vessel rack (1), which comprises a frame (2) with a plurality of openings (3) in the upper surface of the frame for sample vessels (9), and a locking plate member (5) movable in a plane parallel to the upper surface of the frame (2) of the rack from a releasing position to a locking position and back, wherein the removal of the sample vessels (9) from the rack is prevented when the locking plate member is in the locking position, the openings (3) of the upper surface of the frame (2) comprises slots (12) formed on their side, and in the locking position a part of the locking plate member (5) sets itself in the area of the slots. The invention also relates to such a method and a sample vessel rack system.
A method and apparatus for opening a reaction vessel having a body forming a volume for liquid, and a lid. In the method at least one reaction vessel is placed on a transport vehicle and the reaction vessel is positioned on the vehicle so that the vessel's rotation about its own axis is prevented. Then, the at least one reaction vessel is transferred on the vehicle and a guide rod, attached to the lid that is attached by a hinge to the reaction vessel, is pushed by the movement of the vehicle against a guide surface that forces the lid to turn on the hinge so that the lid is at least partially opened.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
64.
METHOD FOR ATTACHING A SAMPLE VESSEL RACK IN AN APPARATUS, SAMPLE VESSEL RACK AND APPARATUS FOR A SAMPLE VESSEL RACK
Method for attaching a sample vessel rack (1, 1') in an apparatus (2, 2', 23), which apparatus comprises a slot (4, 24) into which the sample vessel rack is inserted, wherein magnetic attraction force is utilized in the attachment and correct positioning of the sample vessel rack (1, 1') into the slot (4, 24), where in the slot (4, 24) comprises a movable member (9, 9', 28, 35), which movable member is moved to a locking position with a magnetic attraction force when the sample vessel rack (1, 1') is in a correct position in the slot, and which movable member comprises at least one protrusion (11, 33) which protrusion sets itself in a notch (37) formed in the sample vessel rack in the locking position of the movable member. The invention also relates to such a sample vessel rack and an apparatus, and to a use of such a sample vessel rack.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
A tissue processing apparatus for processing biological tissue. The tissue processing apparatus comprises a measurement probe that includes two measurement surfaces spaced apart from each other, wherein the measurement probe is configured to be inserted into a reagent receptacle so that the two measurement surfaces are at least partially immersed in reagent contained in the reagent receptacle. The tissue processing apparatus is configured to use the two measurement surfaces of the measurement probe to obtain at least one electrical measurement of reagent contained in the reagent receptacle before reagent is taken out from the reagent receptacle by the tissue processing apparatus. The tissue processing apparatus is configured to determine, based on the at least one electrical measurement, a concentration and/or a type of reagent contained in the reagent receptacle.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Laboratory equipment used in specimen preparation, namely, tissue processors for preserving tissues for scientific and clinical research Medical apparatus used in specimen preparation, namely, tissue processors for preserving tissues for medical diagnostic use
A pipette comprising a cylinder with a piston movable inside the cylinder for aspiring and dispensing liquid, and a handle portion for gripping the pipette, wherein the pipette further comprises an imaging device element for obtaining images that assist the use of the pipette.
According to an example aspect of the present invention, there is provided a gripper comprising an actuator (1) and two fingers (10) mounted parallel at a distance from each other on the actuator (1) for movement perpendicularly to a longitudinal axis of the fingers(4), the fingers(4) comprising a longitudinal body (5), means (6, 7, 8) for attaching the body (5) to the actuator(1)and two longitudinal claws (10) at the end opposite to the means (6, 7, 8) of attachment, the claws (10) being spaced apart so that there is an elongate gap (12) between the claws (10).
A pipette is described which includes a piston for aspirating liquid into and dispensing out of a container in the pipette. The pipette is provided with at least one tracking element which is able to count the magnitude of some variable or variables relating to the amount of use of the pipette, at least one operating device for creating a limit magnitude for each variable, and for giving information when the limit value is exceeded. Thus, the user may, for instance, be warned when he may be exposed to high workload stress possibly causing injuries.
An electronic pipette comprising a piston actuated in a cylinder by a motor, a control system for carrying out pipette operations, and a user interface for operating the pipette, which user interface comprises a display, wherein the main menu of the user interface comprises a user defined shortcut to a specific pipetting application.
Described are extraction columns and systems that include extraction columns. The extraction column includes a column body that has a reservoir portion, an extraction media portion, and a collar portion. The reservoir portion includes an inlet and a reservoir. The extraction media portion includes an elongated sleeve having an inner surface defining a cavity. The extraction media portion has an inlet end in fluid communication with the reservoir and an outlet end. An extraction medium is disposed in the cavity of the elongated sleeve. The collar portion extends axially in a common direction with the elongated sleeve. The collar portion has a terminal end which is spaced apart from the outlet end of the elongated sleeve and which extends axially at least to a plane defined by the outlet end of the elongated sleeve.
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
Described are devices, systems, and methods directed to extraction columns. An embodiment of the extraction column includes a column body having a reservoir portion including an inlet and a reservoir, an extraction media portion, and a collar portion. The extraction media portion includes an elongated sleeve having a cavity having an extraction medium disposed therein. The extraction media portion has an inlet end and an outlet end. The collar portion extends axially with the elongated sleeve. The collar portion has a terminal end which is spaced apart from the outlet end of the elongated sleeve and which extends axially at least to a plane defined by the outlet end of the elongated sleeve. Also described is a sheath with a medium disposed therein, wherein the medium is separated from an inner surface of the sheath by a layer configured to substantially prevent a portion of sample from bypassing the medium.
A method for controlling an electronic pipette, which pipette comprises a piston actuated in a cylinder by a motor, which motor is controlled with a control system, which control system is controlled through a user interface for operating the pipette, wherein actual backlash affecting the movement of the piston of the electronic pipette is measured with a system located in the pipette, the measured backlash value is forwarded to the control system of the electronic pipette, and the movement of the piston is adjusted by the control system based on the measured backlash value.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01F 11/02 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific apparatus and instruments; laboratory apparatus
and instruments; test tubes; cuvettes for scientific or
laboratory use; vessels for scientific or laboratory use;
single use vessels for scientific or laboratory use. Medical apparatus and instruments; veterinary apparatus and
instruments; medical diagnostic instruments; testing
instruments for medical diagnostic purposes; tubes for
medical purposes; cuvettes for medical diagnostic purposes;
vessels for medical diagnostic purposes; single use vessels
for medical diagnostic purposes.
A sample vessel (1, 11) for transferring and analyzing a sample with analyzer instrument, which sample vessel comprises an elongated vessel body (2, 12) for containing the sample and a hinged cap (3, 13) connected in top end area of the vessel body, and the cross-section of the vessel body (2, 12) on a transversal plane in relation to the lengthwise center axis of the vessel body the inner surface of the vessel body is rotationally asymmetrical in relation to the lengthwise center axis, wherein the sample vessel (1, 11) comprises a surface (5, 15) extending upwards from the vessel body, which surface partially surrounds the edge of the cap (3, 13), when the cap is in closed position.
A sample vessel rack (1), which comprises a frame (2) with a plurality of openings (3) in the upper surface of the frame for sample vessels (9), and a locking plate member (5) movable in a plane parallel to the upper surface of the frame (2) of the rack from a releasing position to a locking position and back, wherein the removal of the sample vessels (9) from the rack is prevented when the locking plate member is in the locking position, the openings (3) of the upper surface of the frame (2) comprises slots (12) formed on their side, and in the locking position a part of the locking plate member (5) sets itself in the area of the slots. The invention also relates to such a method and a sample vessel rack system.
A bottle compartment (1, 21) for an analyzer instrument, which bottle compartment comprises a frame (3) with a location (4) for a bottle (10, 23) of liquid, and a tube (7, 24) for aspiration of liquid from a bottle at the location for a bottle by the analyzer instrument, wherein the bottle compartment (1, 21) comprises a handle mechanism (2, 22) connected turnably to the frame (3), which handle mechanism in an open position allows access to the location (4) for insertion and removal of a bottle (10, 23) and in a closed position prevents access to the location, and that the tube (7, 24) for aspiration of liquid is connected to the handle mechanism so that when the handle mechanism is turned to the open position the end of the tube is simultaneously moved from the bottle at the location and when the handle mechanism is turned to the closed position the end of the tube is simultaneously moved inside the bottle at the location.
This invention relates to a sampling device comprising a shaft and a sample collection portion removably connected with the shaft, wherein the connection site between the shaft and the sample collection portion is weakened. The in- vention relates also to a combination of a sampling device comprising a shaft and a removable sample collection portion and a sample vessel configured to receive sample collection portion from the shaft.
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
G06F 19/24 - for machine learning, data mining or biostatistics, e.g. pattern finding, knowledge discovery, rule extraction, correlation, clustering or classification
G06G 7/58 - Analogue computers for specific processes, systems, or devices, e.g. simulators for chemical processes
A novel solution is proposed for processing a test tube transported on a test tube carrier by a conveyor so that spilling of the liquid in the test tube is reduced or even prevented, particularly an arrangement for sequencing and guiding travel of test tube carriers transported on at least one conveyor. The arrangement includes at least one rotatable deviator positioned to intersect the at least one conveyor. The deviator includes a horizontal deviator plate including at least one grip for receiving a test tube carrier. One contact surface is positioned vertically at a distance from the deviator plate and aligned with the grip. The contact surface is formed to contact the test tube carrier at a distance from the contact level of the grip and the carrier.
B65G 47/84 - Star-shaped wheels or devices having endless travelling belts or chains, the wheels or devices being equipped with article-engaging elements
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific apparatus and instruments; Laboratory apparatus and instruments; Test tubes; Cuvettes for scientific or laboratory use; Vessels for scientific or laboratory use; Single use vessels for scientific or laboratory use. Medical apparatus and instruments; Veterinary apparatus and instruments; Medical diagnostic instruments; Testing instruments for medical diagnostic purposes; Tubes for medical purposes; Cuvettes for medical diagnostic purposes; Vessels for medical diagnostic purposes; Single use vessels for medical diagnostic purposes.
09 - Scientific and electric apparatus and instruments
Goods & Services
Computer software and computer programs for laboratory magnetic particle processors for purification of biological materials and for operating laboratory purification apparatuses for laboratory use
89.
CHROMATOGRAPHIC MATERIAL AND METHOD FOR PREPARATION THEREOF
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
Inventor
Liu, Xiaodong
Williams, Richard T.
Cui, Xiao
Abstract
A chromatographic materialcomprisinga zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: wherein R1, R2, R3 are independently selected from an oxygen atom that is configured to connect to a substrate atom in the substrate, an oxygen atom that is configured to connect to a silicon atom of an adjacent ligand, a hydroxyl group, a halogen atom, an alkoxy group, a dialkylamino group, an acyl group, an alkyl group, or an aryl group; L1, L2 and L3 are independently hydrophobic moieties; each containing 2 to 30 carbon atoms, wherein there are at least 10 carbon atoms in the combined chain lengths of L1, L2 and L3; X is an O atom, S atom, amide group or sulfonamide group; n is 0 or 1; R4, R5 are independently selected from a hydrogen atom or a hydrocarbon moiety containing 1 to 20 carbon atoms; and Rf is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
Thermo Electron Manufacturing Limited (United Kingdom)
Dionex Corporation (USA)
Inventor
Liu, Xiaodong
Williams, Richard T.
Cui, Xiao
Abstract
A chromatographic material comprising a zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II:
f is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.
A method and an apparatus for optical measurement of a liquid sample (2) placed in a sample well (3) where the sample in the sample well is exposed to excitation light (7) at first wavelength from an excitation light source (4), which excitation light generates a collection of singlet state oxygen molecules from donor molecules in the liquid sample, said singlet state oxygen molecules reacting with acceptor molecules in the liquid sample causing said acceptor molecules to emit chemiluminescence emission light (11) at second wavelength, which second wavelength is shorter than said first wavelength, and where the emission light produced by the excitation light is measured with a detector, characterized in that the excitation light source is a LED (4).
A pipette (1, 21) comprising a cylinder (10) with a piston (11) movable inside the cylinder for aspiring and dispensing liquid, and a handle portion (2) for gripping the pipette, wherein the pipette (1, 21) further comprises an imaging device element (16) for obtaining images that assist the use of the pipette.
The invention relates to a cap (16) for closing a reagent bottle and a gripper for handling an inner part of the closing cap (2). According to the invention, the inner part of the closing cap (2) has a recess (6) for gripping the cap (2) by applying a vacuum. The invention relates also to a system for handling closures, a method for removing a closing cap from a reagent bottle, and a related gripper.
A sample preparation and analysis system. The system includes a sample preparation system and a sample analysis system. The sample preparation system prepares samples in accordance with an assay that is selected from a database containing a plurality of unique assays. The sample analysis system includes an analyzer that is dynamically reconfigurable based on the selected assay so as to analyze the prepared sample in accordance with that selected assay. A data communication link communicates data from the sample preparation system to the sample analysis system to reconfigure the analyzer in accordance with the selected assay.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
H01J 49/26 - Mass spectrometers or separator tubes
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/00 - Particle spectrometers or separator tubes
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
THERMO ELECTRON MANUFACTURING LIMITED (United Kingdom)
DIONEX CORPORATION (USA)
Inventor
Skinley, Kevin
Pohl, Christopher A.
Liu, Xiaodong
Ritchie, Harald
Abstract
A particulate material for chromatographic use comprising silica particles is provided having a skeleton structure containing silsesquioxane cage moieties. The material is useful as a chromatographic material, for example in HPLC. The silica particles may be hybrid organo-silica particles wherein the silsesquioxane moieties comprise a cage structure having silicon atoms positioned at corners of the cage wherein one or more silicon atoms positioned at the corners of the cagecarry an organic group. A preferred method of preparing the particulate material comprises hydrolysing a silsesquioxane as a co-component of a hydrolysis mixture, especially ina Stöber or modified Stöber process.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
Thermo Electron Manufacturing Limited (United Kingdom)
Inventor
Ritchie, Harald
Abstract
A chromatography column (2) containing a bed of packed particles (22, 24, 26, 28, 30), wherein the packed particles comprise fused core particles and the particle diameters of the packed particles vary along the column. Preferably, the particles (2, 24, 26, 28, 30) are arranged according to their average particle diameter, in order of increasing average particle diameter from the inlet end (4) to the outlet end (6). The bed may comprise a plurality of bed sections and each bed section has an average particle diameter calculated from the particles in that section and there are at least two different average particle diameter bed sections, wherein the particles of each bed are separated from particles of an adjacent bed by a partition that is liquid permeable to allow through a flow of mobile phase. A high column efficiency can be provided with lower pressure drop per unit length of the column.
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
A method for controlling an electronic pipette (1), which pipette comprises a piston (11) actuated in a cylinder (10) by a motor (15), which motor is controlled with a control system, which control system is controlled through a user interface (6, 8, 9) for operating the pipette, wherein actual backlash affecting the movement of the piston (11) of the electronic pipette (1) is measured with a system (16) located in the pipette, the measured backlash value is forwarded to the control system of the electronic pipette, and the movement of the piston is adjusted by the control system based on the measured backlash value.
G01F 25/00 - Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume
G01F 11/02 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
