Provided herein are high viscosity friction reducers that are self-degrading and a one-component system using the same high viscosity friction reducers. The high viscosity friction reducer is a crosslinked polymer, for example a crosslinked cationic polymer such as a polyacrylamide polymer. The high viscosity friction reducers are useful in a fracture well self-cleaning system without the need of a breaker.
Provided herein are wearable devices and systems therewith configured with wearable sensors, a machine learning framework with a machine learning model, and reinforcement learning models. Also provided are methods utilizing the wearable devices and technologies for understanding and optimizing emotional states in a subject and for predicting anxiety in a subject.
A61B 5/16 - Devices for psychotechnicsTesting reaction times
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61M 21/02 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
A flame-retardant treatment composition includes a polyamine, a phosphoric acid methacrylate ester, and a photoinitiator. A flame-retardant coating includes a photopolymerized product of the flame-retardant treatment composition. A flame-retardant substrate includes a porous substrate such as wood or a fiber and the flame-retardant coating thereon.
C09D 4/06 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups
C09D 133/14 - Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
4.
INORGANIC IONS AND BIOMATERIALS TO DRIVE STEM CELL DIFFERENTIATION
The present disclosure provides compositions and methods for increasing osteoblast or chondrocyte differentiation. The present disclosure further provides inorganic ion compositions, including silver ion composition and copper ion compositions. Aspects of the disclosure further relate to methods for treating diseases or disorders associated with altered osteoblast or chondrocyte differentiation, growth, or function.
A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
The disclosure relates to a method for forming a flame-retardant coated substrate, the method comprising, among other things, exposing a substrate to the combined aqueous solution to give a treated substrate; and exposing the treated substrate to a buffer solution to produce a flame-retardant coated substrate, wherein a coating on the flame-retardant coated substrate comprises a polyelectrolyte complex formed between the polymeric, polycationic material and the polyborate salt.
Disclosed is a reactor thermal management system. A molten salt reactor vessel and a second component (e.g., a drain tank) fluidly coupled with the molten salt reactor vessel are configured to receive a flow of a molten salt therewith. The reactor thermal management system includes an internal shield or vessel encompassing the molten salt reactor vessel and the second component, the internal shield or vessel defining a first thermally insulative region therein. The internal shield or vessel is configured to maintain the first thermally insulated region above a melting temperature of the molten salt during operation of the molten salt reactor vessel.
A deployable anti-fatigue mat for a stool includes a first portion flexibly joined to a second portion along a common edge, the first portion comprising a footrest secured thereto and the second portion being configured to be movably attached to a base of the stool.
A secure system for sending and receiving remote signals that control semiautonomous critical systems and infrastructure. The secure system includes a plurality of independent operator stations to provide command signals to the remote critical systems and infrastructure by means of wired and/or wireless communications. Decoupling of the secure system from raw signals is performed by a data broker that serves to check for time-dependent and signal-dependent corroboration between the raw signals and then provide limited-scope instructions to the secure system controller. Further security is afforded to the secure system through encryption of the incoming command signals, convoluting the encrypted command signals within data structures, and padding with erroneous information with the implementation of a synthesized command signal that renders successfully decrypted and deconvoluted command signals neither readable by humans or machines. The final method of data security is appropriated through the synthesis of transmitter/receiver unique “languages” that serve to translate decrypted and unconvoluted signals into their final human/machine readable instructions.
G06F 21/72 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure computing or processing of information in cryptographic circuits
A leak detection system includes a leak detection apparatus. The leak detection apparatus includes an electrode mesh and an insulative layer associated with the electrode mesh. The insulative layer is engageable with a conducting fluid containing component. The electrode mesh is configured to output an electric signal responsive to a conducting fluid reaching the electrode mesh through the insulative layer. The leak detection apparatus further includes a computing device configured to receive said electrical signal and associate said electrical signal with a leak event by correlating said electrical signal with a baseline electrical output of the electrode mesh.
G01M 3/16 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means
Provided are systems, methods, and apparatuses for systems and methods of memory efficient multi-vector information retrieval based on embeddings from a storage pipelined network. In one or more examples, the systems, devices, and methods include performing a first portion of a nearest neighbor search on a first subset of a set of media sources; performing a fetch process on the first subset that include identifying a first set of highest matching media sources from the first subset, transferring multi-vector representations of the first set of highest matching media sources from a storage drive to a memory, and performing a second ranking of the first set highest matching media sources. The systems, devices, and methods include performing, in parallel with the fetch process, a second portion of the nearest neighbor search on a second subset of the set of media sources.
A microfluidic device including an interdigitated electrode (IDE) structure having a plurality of IDE pairs, each of which may include a first electrode and a second electrode. Also, a method including placing a fluid sample and/or cells in contact with an interdigitated electrode (IDE) structure having a plurality of IDE pairs, each of which may include a first electrode and a second electrode. The method may further include measuring electrical impedance between the first electrode and the second electrode over time to analyze the degree of corrosion based on impedance value changes over time as the corrosive electrodes erode over time due to corrosion. The IDE pairs purely composed of non-corrosive metal may provide a baseline impedance value that can be used to calibrate and/or normalize the impedance values of the IDE pairs composed of non-corrosive and corrosive electrode pair.
G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
The present disclosure relates to compositions and methods for the treatment and/or prevention of SARS-COV-2 infections. In one embodiment the method comprises the delivery of a pharmaceutical composition comprising a SARS-COV-2 neutralizing synthetic protein, optionally wherein the protein is a trimeric protein composed of designed ankyrin repeat protein (DARPin) fused with a T4 foldon peptide that is administered non-invasively such as by nasal inhalation.
Technologies for optically controlling friction include a plasmon-active photofriction element, or a friction pixel. A structure includes a base substrate material, a plasmon-active element coupled to the base substrate material, and a frictional interface material. The frictional interface material is positioned at a surface of the structure and has a phonon mode. The plasmon-active element includes a pattern comprising multiple pattern elements that have a plasmon mode tuned to couple with the phonon mode of the frictional interface material. When illuminated, the plasmon mode of the plasmon-active element is excited. Thus, energy dissipation of a sliding contact across the surface of the structure is changed to generate an active decrease or increase in friction based on light illumination frequency or intensity. The frictional interface material may include silica, and the plasmon-active element may include graphene. Other embodiments are described and claimed.
Some T-cell receptors (TCRs) require many ligands for activation while others need only a few, functioning in analog or digital modes, correspondingly. Digital performance is best but undiscernible using conventional functional avidity or TCR sequence distance metrics. Correlates of optimal biophysical parameters include magnitudes of ERK phosphorylation, CD3 surface loss, and activation marker upregulation. The disclosed findings underscore the requirement to match TCR performance quality with pMHC copy number, as nature does. Given tumor antigen array paucity, engaging superior digital TCRs appears critical for T-cell adoptive cancer therapies and vaccines. Therefore, disclosed herein are methods for detecting digital T cell receptor interactions with presented antigen and selecting a T cell or antigen based on these methods. Also disclosed are adoptive cell transfer methods for treating a subject with digital T cells identified by the disclosed methods. In addition, disclosed are methods for designing RNA vaccines based on the copy number that elicits a digital T cell response.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
G01N 33/557 - ImmunoassayBiospecific binding assayMaterials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
C07K 14/74 - Major histocompatibility complex [MHC]
An apparatus for converting heavy hydrocarbons to light hydrocarbons includes an inlet capable of supplying a pre-foaming mixture comprising a hydrocarbon to be processed and a processing gas, wherein the processing gas is dissolved in the hydrocarbon to be processed; a foam generator configured to receive the pre-foaming mixture at a first pressure, compress the pre-foaming mixture to a second pressure that is higher than the first pressure by routing it through a nozzle; and generate a foam by allowing the pre-foaming mixture at the second pressure to expand in a chamber at a third pressure that is lower than the first or second pressures; a plasma reactor, wherein the plasma reactor is capable of receiving the foam and comprises at least one pair of spark gap electrodes capable of subjecting the foam to a plasma discharge to yield a processed mixture; and an outlet capable of receiving the processed mixture.
C09K 23/00 - Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
C10G 49/00 - Treatment of hydrocarbon oils, in the presence of hydrogen or hydrogen-generating compounds, not provided for in a single one of groups , , , , or
Embodiments of the invention are directed to biosensors comprising one or more encapsulated functionalized domains, where the encapsulating matrix acts as the primary interface between the biosensor and the environment. Embodiments of the invention are also directed to the fabrication of the biosensor.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/54 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving glucose or galactose
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
H10F 30/10 - Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices being sensitive to infrared radiation, visible or ultraviolet radiation, and having no potential barriers, e.g. photoresistors
Board of Regents, The University of Texas System (USA)
Inventor
Haas, Derek
Robison, Jordan
Biegalski, Steven
Head, Timothy
Towell, Rusty
Clarno, Kevin
Petrovic, Bojan
Tsvetkov, Pavel
Scherr, Jonathan
Kimber, Mark
Abstract
An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
G21C 1/32 - Integral reactors, i.e. reactors wherein parts functionally associated with the reactor but not essential to the reaction, e.g. heat exchangers, are disposed inside the enclosure with the core
G21C 3/54 - Fused salt, oxide, or hydroxide compositions
G21C 7/30 - Control of nuclear reaction by displacement of reactor fuel or fuel elements
18.
HYDRO-ELECTROCHEMICAL POWER GENERATORS AND ASSOCIATED METHODS
A hydro-electrochemical power generator includes an interlayer having a first end and a second end opposite the first end, a first electrode in contact with the first end of the interlayer, wherein the first electrode includes a first material that is a corrodible metallic material, a second electrode in contact with the second end of the interlayer, wherein the second electrode includes a second material that is a corrodible metallic material, and at least one heat source coupled to one of the first electrode and the second electrode and configured to apply a temperature gradient across the first end and the second end of the interlayer, and wherein the first electrode and the second electrode are configured to output a non-zero electrical voltage in response to the application of the temperature gradient.
H10N 10/13 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects characterised by the heat-exchanging means at the junction
H01M 6/36 - Deferred-action cells containing electrolyte and made operational by physical means, e.g. thermal cells
H10N 10/856 - Thermoelectric active materials comprising organic compositions
In an embodiment, the present disclosure pertains to a solvent including a hydrocarbon oligomer with at least 20 carbon atoms, where the hydrocarbon oligomer has at least one of a low viscosity, a low vapor pressure, and a high flashpoint. In another embodiment, the present disclosure pertains to a solution including a poly (α-olefin) and a reactive organometallic reagent. In a further embodiment, the present disclosure pertains to a solution including an oligomeric hydrocarbon and a reactive organometallic reagent. In an additional embodiment, the present disclosure pertains to a method for creating a solution, where the method includes adding a reactive organometallic reagent to an oligomeric hydrocarbon.
B01J 31/12 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
B01J 31/06 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
B01J 35/27 - Catalysts, in general, characterised by their form or physical properties characterised by their non-solid state in a liquid or molten state
C07C 33/20 - Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
C07C 49/76 - Ketones containing a keto group bound to a six-membered aromatic ring
C07C 233/65 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
20.
PROCESS FOR PREPARATION OF PLASTIC COPPER NANOWIRE COMPOSITION
Formosa Plastics Corporation (Taiwan, Province of China)
Inventor
Sue, Hung-Jue
Tsai, Chia-Ying
Chen, Kwang-Ming
Hsieh, Kun-Pei
Chang, Chao-Shun
Huang, Ssu-Ping
Abstract
The present disclosure provides a copper nanowire composition. The a copper nanowire composition includes copper nanowire having associated alkylamine ligands with the structure HNR1R2. where R1 and R2 are independently hydrogen, alkyl or arylalkyl groups. The copper nanowire has an aspect ratio of at least 10. The associated alkylamine ligand is NR1R2 which contains at least 12 carbon atoms.
B22F 1/07 - Metallic powder characterised by particles having a nanoscale microstructure
B22F 1/102 - Metallic powder coated with organic material
B22F 1/107 - Metallic powder containing lubricating or binding agentsMetallic powder containing organic material containing organic material comprising solvents, e.g. for slip casting
B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
C08J 3/20 - Compounding polymers with additives, e.g. colouring
C08J 3/205 - Compounding polymers with additives, e.g. colouring in the presence of a liquid phase
C08J 3/215 - Compounding polymers with additives, e.g. colouring in the presence of a liquid phase the polymer being premixed with a liquid phase at least one additive being also premixed with a liquid phase
An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
A method of delivering a recombinant adeno-associated virus (rAAV) or a biologic to cytosol of a plurality of cells is described. In an embodiment, the method comprises contacting the plurality of cells with the rAAV; contacting the plurality of cells with a cationic amphiphilic drug (CAD), thereby delivering the rAAV to the cytosol of the plurality of cells. In an embodiment, the method comprises contacting the plurality of cells with the biologic; contacting the plurality of cells with cell penetrating peptides (CPP); contacting the plurality of cells with a CAD, thereby delivering the biologic to the cytosol of the plurality of cells.
22). Also provided are methods for detecting and monitoring physiological changes via the wearable electronic skin and for diagnosing a disease or disorder based on the physiological changes.
The present disclosure relates to anti-fibrotic sialidase-inhibitor compounds and methods of preventing or inhibiting fibrosis using such compounds. The present disclosure also relates to methods of controlling the formation of fibrocytes or their activity using such compounds. The compounds may include both antibodies as well as small molecules. The methods may involve administering the compounds to a patient with or at risk of developing fibrosis in a manner that inhibits at least one sialidase in the patient.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61P 11/00 - Drugs for disorders of the respiratory system
A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue
C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (Tg) of the SMP foam to below 25° C. Other embodiments are described herein.
A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
A microfluidic device includes a microfluidic channel formed in the microfluidic device and defined by a floor and a ceiling positioned vertically above the floor, wherein the microfluidic channel includes at least one fluid inlet configured to receive a fluid flow and at least one fluid outlet, and wherein at least one of the ceiling and the floor of the microfluidic channel is sloped relative to a horizontal plane.
B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
C08F 2/48 - Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
An embodiment includes a process for treating an abdominal aortic aneurysm (AAA) endoleak with a shape memory polymer (SMP) foam device. First, a bifurcated stent graft is placed within the aneurysm while a micro guidewire is positioned within the aneurysm for future catheter access. Second, after placing the iliac graft extension, a catheter is introduced over wire to deliver embolic foams. Third, embolic foams expand and conform to the aneurysm wall. Fourth, embolic foams create a stable thrombus to prevent endoleak formation by isolating peripheral vessels from the aneurysm volume.
A61L 31/14 - Materials characterised by their function or physical properties
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61F 2/945 - Stents retaining their form, i.e. not being deformable, after placement in the predetermined place hardenable, e.g. stents formed in situ
A61F 2/954 - Instruments specially adapted for placement or removal of stents or stent-grafts for placing stents or stent-grafts in a bifurcation
A61L 31/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 31/18 - Materials at least partially X-ray or laser opaque
31.
SHAPE-MEMORY POLYMER FOAM DEVICE FOR TREATING ANEURYSMS
A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
A device for a tissue channel includes a device frame, a shape memory polymer foam segment coupled to the device frame, and an attachment structure coupled to the device frame. The device frame includes a proximal structure, a distal structure, and an intermediate structure coupled to the proximal structure and the distal structure. The proximal structure is configured to collapse to fit into a delivery structure and expand to block migration of the proximal structure. The distal structure is configured to collapse to fit into the delivery structure and expand to block migration of the distal structure. The intermediate structure is configured to fit in the tissue channel upon device deployment. The shape memory polymer foam segment is configured to compress to fit into the delivery structure and occlude the channel. The attachment structure is configured to attach and detach the device from a delivery guide.
41 - Education, entertainment, sporting and cultural services
Goods & Services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting lectures; providing news and information in the field of academics
Disclosed is a new variety of Prunus persica named ‘Flat Delight Three’. This new variety, which requires approximately 350 chilling units of dormancy, is considered to be a peach tree of early season maturity, which produces subacid, white-fleshed flat (pantao) fruit that are firm, with the skin covered on 50-80% of its surface with a dark pink to dark maroon blush over a light yellow ground color, and suitable for both local and long-distance shipping.
A method of removing pollutants from flue gas includes cooling the flue gas to remove condensed water. The flue gas is then compressed and dehydrated. The dehydrated flue gas is chilled to separate pollutants.
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
Disclosed herein are solid-liquid composites including a crosslinked polymer network having a plurality of inclusions dispersed therein. The inclusions can be regularly spaced apart within the composite. The volume and composition of the inclusions can be controlled to give composites having a variety of different mechanical properties. The composites can be used as surgical phantoms, including cerebrovascular surgical phantoms.
An instrumented blanket includes an insulative material and a temperature control structure integrated with the insulative material. The heating structure is configured to produce a heat or a cooling output in response to an input signal. The temperature-control blanket further includes an optical sensor including an optical fiber integrated with the insulative material along the heating structure. The optical sensor is configured to detect a change in an optical property measured from a plurality of intervals along a length of the optical fiber. The change in the optical property is indicative of a temperature of the temperature-control blanket at a respective interval of the plurality of intervals.
G21C 1/03 - Fast fission reactors, i.e. reactors not using a moderator cooled by a coolant not essentially pressurised, e.g. pool-type reactors
G01K 11/32 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in transmittance, scattering or luminescence in optical fibres
G21C 3/24 - Fuel elements with fissile or breeder material in fluid form within a non-active casing
B01F 23/23 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
38.
SYSTEMS AND METHODS FOR DISCOVERY AND PREDICTING PHENOTYPES
An example method of predicting a phenotype of interest of a subject includes generating apluralityofbiomarkers; selectingasubsetofbiomarkersfromthepluralityofbiomarkers;anddeterminin garelationshipbetweenthesubsetofbiomarkersandthephenotypeofinterest;receivingsample biomarkers;where thesample biomarkerscomprise oneor more measurementsofthesubject;andpredictingthephenotypeofinterestofthesubjectbasedonthesampleb iomarkers and the relationship between the subsetof biomarkers and the phenotype of interest.
Provided herein are nanoengineered biomaterial inks used to 3D print a biocompatible, flexible electronic device, for example, a hydrogel constructs a biocompatible, flexible electronic device or 3D printed wearable electronic devices. The biocompatible, flexible electronic device may be a crosslinked gelatin-SH-2D-MoS2 nanoassembly. Also provided are methods for nanoengineering a biomaterial ink and for determining a treatment for a subject in need thereof utilizing the biocompatible, flexible electronic device.
B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
The present disclosure provides compositions and methods for increasing mitochondrial function or decreasing cellular oxidative stress. The present disclosure further provides nanomaterial structures comprising high atomic vacancy concentrations. Aspects of the disclosure further relate to methods for treating diseases or disorders associated with decreased mitochondrial function or increased cellular oxidative stress.
A61K 33/00 - Medicinal preparations containing inorganic active ingredients
A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
A61K 47/52 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
A bioreactor device may include a housing assembly having a body defining a bioreactor cavity with an opening, a lid to be received by the opening and including rack openings, and a port coupled to the bioreactor cavity. The bioreactor device may also include racks respectively received by the rack openings. Each of the racks may include a vertical arm, vertically spaced supports coupled to the vertical arm, and substrates respectively carried by the vertically spaced supports, each substrate having culture media thereon. The bioreactor device may also include a control unit coupled to the port and configured to selectively supply culture medium to the bioreactor cavity based upon a characteristic within the bioreactor cavity.
An example system for predicting a phenotypic measurement includes a remote sensing platform comprising a remote sensor configured to capture image data, where the image data comprises a plurality of temporally-spaced images of a plant; and a computing device operably coupled to the remote sensing platform, where the computing device includes at least one processor and memory, the memory having computer-executable instructions stored thereon that, when executed by the at least one processor, cause the at least one processor to: input the image data into a prediction model; and determine, using the prediction model, a phenotypic measurement.
An instrumented blanket includes an insulative material and a temperature control structure integrated with the insulative material. The heating structure is configured to produce a heat or a cooling output in response to an input signal. The temperature-control blanket further includes an optical sensor including an optical fiber integrated with the insulative material along the heating structure. The optical sensor is configured to detect a change in an optical property measured from a plurality of intervals along a length of the optical fiber. The change in the optical property is indicative of a temperature of the temperature-control blanket at a respective interval of the plurality of intervals.
G01K 11/3206 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in transmittance, scattering or luminescence in optical fibres at discrete locations in the fibre, e.g. using Bragg scattering
G01K 7/02 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using thermoelectric elements, e.g. thermocouples
44.
SYSTEMS AND METHODS FOR DETECTING AND PREDICTING PHENOTYPIC MEASUREMENTS AND PHENOTYPES
An example system for predicting a phenotypic measurement includes a remote sensing platform comprising a remote sensor configured to capture image data, where the image data comprises a plurality of temporally-spaced images of a plant; and a computing device operably coupled to the remote sensing platform, where the computing device includes at least one processor and memory, the memory having computer-executable instructions stored thereon that, when executed by the at least one processor, cause the at least one processor to: input the image data into a prediction model; and determine, using the prediction model, a phenotypic measurement.
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
An example method of predicting a phenotype of interest of a subject includes generating a plurality of biomarkers; selecting a subset of biomarkers from the plurality of biomarkers; and determining a relationship between the subset of biomarkers and the phenotype of interest; receiving sample biomarkers; where the sample biomarkers comprise one or more measurements of the subject; and predicting the phenotype of interest of the subject based on the sample biomarkers and the relationship between the subset of biomarkers and the phenotype of interest.
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
46.
ELECTROCHEMICAL STORAGE INCORPORATING SIZE- AND MORPHOLOGY-CONTROLLED METASTABLE VANADIUM PENTOXIDE AS A CATHODE MATERIAL FOR ION BATTERIES
The Li-ion paradigm of battery technology is fundamentally constrained by the monovalency of the Li-ion. A straightforward solution is to transition to multivalent ion chemistries, with Mg2+ the most obvious candidate due to considerations of size and mass. Despite early interest, the realization of Mg batteries has faced myriad obstacles, including a sparse selection of cathode materials demonstrating the ability to reversibly insert divalent ions. Disclosed herein is evidence of reversible topochemical and electrochemical insertion of Mg2+ into a metastable one-dimensional polymorph of V2O5. Not only does ζ-V2O5 represent a rare addition to the pantheon of functional Mg battery cathode materials, but is also distinctive in exhibiting a combination of high stability, high specific capacity due to ion insertion, and moderately high operating voltage.
In an embodiment. the present disclosure pertains to environmental biospecimen recovery after in-droplet gel encapsulation (eBRIDGE) platforms for co-culturing multiple microorganisms in gel microspheres and then transferring single-cell-derived clonal populations from within the gel microspheres into separate water-in-oil emulsion droplets for further processing and analysis. In some embodiments. the gel-encapsulated bacteria are released by lysing the gel matrix using an enzyme. The methods of the present disclosure provide a single workflow that goes from environmental microbial harvesting and amplification to functional interrogation of their characteristics.
A wearable biosensor for real-time quantification of a biomarker in a biofluid includes at least one functional module. The functional module includes an iontophoresis induction module, a microfluidic layer, a plurality of multimodal biosensors, and a paperfluidic layer.
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
49.
SMART SINGLE-DOMAIN INTRABODIES WITH PRECISION SWITCHES FOR BIOMEDICAL APPLICATIONS
The present disclosure provides intrabody compositions comprising i) an intrabody and ii) one or more inserts. The disclosure also provides methods for activating and deactivating intracellular and extracellular interactions utilizing the compositions, for instance via chemical and/or light.
C07K 14/71 - ReceptorsCell surface antigensCell surface determinants for growth factorsReceptorsCell surface antigensCell surface determinants for growth regulators
A61K 47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
50.
PHYSIOLOGICALLY RELEVANT PUMPS AND ASSOCIATED SYSTEMS AND METHODS
A physiologically relevant pump includes a support frame, a flexible bladder sealingly coupled to the support frame, a mechanical drive coupled to at least one of the support frame, and a pump motor coupled to the support frame and the mechanical drive and configured, in response to receiving a control signal, to displace, through the mechanical drive, a first end of the flexible bladder relative to a second end of the flexible bladder to alter an internal volume of the flexible bladder whereby a desired fluid pressure in an internal chamber of the flexible bladder is achieved.
G05D 7/06 - Control of flow characterised by the use of electric means
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
A61B 6/58 - Testing, adjusting or calibrating thereof
51.
CYNOBACTERIA CULTIVATION, SEDIMENTATION, AND UTILIZATION
The present invention is related to the fields of bioplastics. In particular, a strain of photosynthetic cyanobacteria (i.e. blue-green algae) having a high growth rate was engineered to overexpress limonene synthase. These engineered cyanobacteria improve auto-sedimentation for biomass harvest and provide for plastic bioremediation capture. Further, machine-learning methods are provided for improving some of the aspects of cultivating cyanobacteria including, but not limited to, assessing real-time light availability and predicting real-time algae growth rates to increase a cyanobacteria biomass.
In an embodiment, the present disclosure pertains to a method of deposition of nanostructures with engineered patterns. In an additional embodiment, the present disclosure pertains to a method of preparing colloidal suspensions of hybrid nanoparticle systems (HNMS). In a further embodiment, the present disclosure pertains to a method of making a cellulose nanocrystal (CNC)-bonded carbon nanotube carbon fiber reinforced polymer (CNT-CFRP) hybrid composite. In another embodiment, the present disclosure pertains to a method of making a cellulose nanocrystal (CNC)-bonded graphene nanoplatelets (GNP) carbon fiber reinforced polymer (GNP-CFRP) hybrid composite. In a further embodiment, the present disclosure pertains to a method of making a hybrid cellulose nanocrystal (CNC)-graphene nanoplatelet(boron nitride nanobarb) (GNP-(BNNB))-carbon fiber (CF)Zpolyether ether ketone (PEEK) using spray-coating.
A wearable biosensing system includes a case, a contact carriage, a biosensor, and a contact pressure management unit. The case is adapted to be fixed to a skin surface of a user. The contact carriage is mounted for movement relative to the case into contact with the skin surface of the user to apply a contact pressure to the skin surface of the user. The biosensor is configured to measure physiological signals of the user. The contact pressure management includes at least one pressure sensor configured to output pressure data.
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/0295 - Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
41 - Education, entertainment, sporting and cultural services
Goods & Services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
41 - Education, entertainment, sporting and cultural services
Goods & Services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
56.
CEASELESS INDUSTRY FEARLESS INVESTIGATION UNFETTERED THOUGHT UNSELFISH SERVICE EAST TEXAS A&M UNIVERSITY 1889
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college graduation ceremonies.
41 - Education, entertainment, sporting and cultural services
Goods & Services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
41 - Education, entertainment, sporting and cultural services
Goods & Services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting lectures; providing news and information in the field of academics
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life.
63.
SYNTHETIC PROTEIN SCAFFOLDS TO TARGET AND REMOVE BACTERIAL VIRULENCE PILI
Synthetic bacterial phage maturation (Mat) protein scaffolds, compositions, and methods of use to decrease bacterial virulence, treat and prevent bacterial infections, and lower the incidence of bacterial gene transfers to combat the spread of treatment-resistant bacterial strains. Scaffolds include at least a portion of an apical domain of a Mat protein and can decrease type IV pili (T4P) attachment for reduction of bacterial virulence.
An apparatus for surgical lighting is disclosed. The apparatus includes a light emitting element formed with a light source encapsulated within an outer layer. The outer layer includes a biocompatible material. A power supply is coupled to the light source. The apparatus includes an actuating mechanism that controls power from the power supply to the light source to emit light along a surgical area. The light emitting element provides enhanced illumination and other surgical advantages.
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
F21S 2/00 - Systems of lighting devices, not provided for in main groups or , e.g. of modular construction
A passive infrared (PIR) sensor system, includes a PIR sensor configured to produce an output signal in response to receiving infrared (IR) radiation, an electronic shutter positionable in a field of view (FOV) of the PIR sensor, wherein the electronic shutter includes a liquid crystal (LC) material, wherein the electronic shutter includes a first state providing a first transmissivity of IR radiation through the electronic shutter and a second state providing a second transmissivity of IR radiation through the electronic shutter that is less than the first transmissivity, and a shutter actuator configured to apply an actuation signal to the electronic shutter to actuate the electronic shutter between the first state and the second state.
G01J 5/0875 - WindowsArrangements for fastening thereof
G01J 5/34 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors using capacitors, e.g. pyroelectric capacitors
Described herein are compounds and methods for the treatment of coronavirus infection. The compounds can function as an inhibitor of the main protease (Mpro) of coronaviruses. The compounds can include diphenylmethyl piperazine derivatives, diphenylmethyl piperidine derivatives, diphenylmethylidene piperidine derivatives, tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen derivatives, tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen derivatives, 6,11-dihydrobenzo[c][1]benzoxepin derivatives, 6,11-dihydrobenzo[c][1]benzothiepin derivatives, 5,5-dioxo-6,11-dihydrobenzo[c][1]benzothiepin derivatives, and 6-oxo-5,11-dihydrobenzo[c][1]benzazepin derivatives, as well as pharmaceutically acceptable salts, hydrates, and prodrugs thereof.
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/4995 - Pyrazines or piperazines forming part of bridged ring systems
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
The current disclosure provides polypeptides and peptides comprising SEQ ID NO: 1. Antibodies or antigen binding fragments thereof specifically bind to a polypeptide comprising SEQ ID NO: 1 or peptide fragments thereof (e.g., SEQ ID NOs: 2 and/or 3) are also provided. Accordingly, the current disclosure provides polypeptides and peptides comprising ant one of SEQ ID NOs: 1-6 or fragments thereof. The antibodies or antigen binding fragments thereof can be monoclonal antibodies (Mab), chimeric antibodies, single chain antibodies, single chain fragment variable (scFv) antibodies, or fragment antigen-binding (Fab fragment). The antibodies or antigen binding fragments thereof can be labeled with an enzyme, a radioisotope, a fluorescent label, or a bioluminescent label and/or used in diagnostic assays. Diagnostic assays and vaccines using the disclosed polypeptides or fragments thereof are also provided.
Provided are compositions and methods for modifying a plant genome. Methods and compositions are also provided for delivering genome editing components across graft junctions and generating genome modified plants in the presence of a selection agent without integration of a selectable marker gene into the genome. Recombinant DNA constructs for modifying a plant genome and plants comprising the same are further provided.
Toyota Motor Engineering & Manufacturing North America, Inc. (USA)
Toyota Jidosha Kabushiki Kaisha (Japan)
The Texas A&M University System (USA)
Inventor
Ponce Valderrama, Victor
Marjuban, Shaik Merkatur Hakim
Castaneda-Lopez, Homero
Eich, Heather M.
Tarr, Walter D.
Abstract
A corrosion monitoring system includes a processor, and a memory in communication with the processor and having a control module, a potentiostat, coupled to a clamp with a first plate and a second plate. The control module includes instructions that, when executed by the processor, cause the processor to control the potentiostat to apply a voltage to the first plate and the second plate during an EIS test of a coating on a metal substrate disposed between the first plate and the second plate. The corrosion monitoring system also monitors or detects a change in at least one of a phase angle and an impedance of the applied voltage, and identifies a change in corrosion activation at the substrate for any coating system based, at least in part, on the change in the at least one of the phase angle and the impedance.
A biosensor for in situ continuous monitoring of molecular biomarkers includes a flexible organic or inorganic layer, and a biorecognition element microarray placed on the organic or inorganic layer. In some aspects, the flexible layer is placed upon a disk that may be made of, for example, one or more of poly dimethylsiloxane (PDMS), silicone, polyurethane, polymers, and hydrogels. The organic or inorganic layer enables the immobilization of biorecognition elements, such as polystyrene (PS) film comprises functional groups from Gamma irradiation to increase biorecognition element binding. The biorecognition elements may include, for example, one or more of an antibody, aptamer, peptide, molecularly imprinted polymers, nucleic acid.
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
71.
SYSTEMS AND METHODS FOR IDENTIFYING ONE OR MORE SUBSTANCES USING MICRO-PLASMA INDUCED BREAKDOWN SPECTROSCOPY
A system for identifying one or more substances in a liquid sample using micro¬ plasma induced breakdown spectroscopy (MIBS) includes a system controller including a processor and memory encoded with instructions that, when executed by the processor, cause the processer to activate one or more pulse generators to apply one or more electrical pulses to a plasma electrode whereby a plasma discharge is generated in the liquid sample when the liquid sample is received in the plasma receptacle, wherein the voltage of each of the one or more electrical pulses applied to the plasma electrode is between 13 kilovolts (kV) and 40 kV, and activate an optical detector to identify the one or more substances in the liquid sample based on an optical signal from the plasma discharge that is collected by an optical collector.
G01N 21/73 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited using plasma burners or torches
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 21/85 - Investigating moving fluids or granular solids
G01N 21/71 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited
H05H 1/16 - Arrangements for confining plasma by electric or magnetic fieldsArrangements for heating plasma using applied electric and magnetic fields
H05H 1/18 - Arrangements for confining plasma by electric or magnetic fieldsArrangements for heating plasma using applied electric and magnetic fields wherein the fields oscillate at a very high frequency, e.g. in the microwave range
A61K 31/4406 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
73.
COMPOSITIONS AND METHODS FOR GENOME EDITING ACROSS GRAFT-JUNCTIONS
Provided are compositions and methods for modifying a plant genome. Methods and compositions are also provided for delivering genome editing components across graft junctions and generating genome modified plants in the presence of a selection agent without integration of a selectable marker gene into the genome. Recombinant DNA constructs for modifying a plant genome and plants comprising the same are further provided.
C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
A01H 4/00 - Plant reproduction by tissue culture techniques
Disclosed herein are antisense oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA at the 5′-end of UBE3A-AS, which is downstream of SNORD115-45 snoRNA. Also disclosed are pharmaceutical compositions and methods for treatment of Angelman syndrome.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Board of Regents, The University of Texas System (USA)
Inventor
Haas, Derek
Robison, Jordan
Biegalski, Steven
Head, Timothy
Towell, Rusty
Clarno, Kevin
Petrovic, Bojan
Tsvetkov, Pavel
Scherr, Jonathan
Kimber, Mark
Abstract
An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
G21C 1/32 - Integral reactors, i.e. reactors wherein parts functionally associated with the reactor but not essential to the reaction, e.g. heat exchangers, are disposed inside the enclosure with the core
G21C 7/30 - Control of nuclear reaction by displacement of reactor fuel or fuel elements
76.
CORN ENDOTYPE-DERIVED POLYPEPTIDES CAPABLE OF METABOLIZING FUMONISIN
Polynucleotides and polypeptides conferring the ability to detoxify or metabolize the mycotoxin fumonisin are provided, as are constructs, compositions, and plants comprising the polynucleotides and polypeptides. Also provided are plants having the ability to detoxify fumonisin, methods of conferring fumonisin detoxification, methods of controlling fumonisin contamination, and kits and methods for identification of plants having the ability to detoxify fumonisin.
C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventor
Haas, Derek
Robison, Jordan
Biegalski, Steven
Head, Timothy
Towell, Rusty
Clarno, Kevin
Petrovic, Bojan
Tsvetkov, Pavel
Scherr, Jonathan
Kimber, Mark
Abstract
An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
G01C 3/30 - Measuring distances in line of sightOptical rangefinders using a parallactic triangle with fixed angles and a base of variable length at, near, or formed by, the object with provision for reduction of the distance into the horizontal plane with adaptation to the measurement of the height of an object, e.g. tacheometers
G21C 3/54 - Fused salt, oxide, or hydroxide compositions
G21C 7/30 - Control of nuclear reaction by displacement of reactor fuel or fuel elements
G21C 9/00 - Emergency protection arrangements structurally associated with the reactor
G21C 9/02 - Means for effecting very rapid reduction of the reactivity factor under fault conditions, e.g. reactor fuse
Embodiments of the disclosure include compositions comprising peptides with an N-terminal capping motif or with the combination of an N-terminal capping motif and a C-terminal capping motif, and methods for synthesizing the peptides. The capping motifs can impart helicity to peptides that otherwise do not exhibit helicity. The helix capping motifs are conformationally rigid, improve peptide serum stability, and increase cell permeability of peptides.
Polynucleotides and polypeptides conferring the ability to detoxify or metabolize the mycotoxin fumonisin are provided, as are constructs, compositions, and plants comprising the polynucleotides and polypeptides. Also provided are plants having the ability to detoxify fumonisin, methods of conferring fumonisin detoxification, methods of controlling fumonisin contamination, and kits and methods for identification of plants having the ability to detoxify fumonisin.
The present disclosure pertains to a circulating tumor cell (CTC) microfluidic platform that is used for the detection of CTCs, enumeration of CTCs in a sample, characterization of biophysical properties, CTC cell size, CTC cell membrane deformability, stresses on CTC cell membranes, adhesion stress on CTC cells, normal stress of CTC cells, or combinations thereof.
Embodiments of the disclosure include compositions comprising peptides with C-terminal capping motifs, and methods for making the compositions. The capping motifs impart helicity to C-termini of peptides that otherwise do not exhibit helicity. The helix capping motifs are conformationally rigid, stable in serum, and increase cell permeability of peptides.
In an embodiment, the present disclosure pertains to a droplet system, apparatus, or fluid sample testing system to accomplish high-precision and high-efficiency droplet manipulation (e.g., greater than 99% platform operation efficiency). In some embodiments, the droplet system, apparatus, or fluid sample testing system includes at least one microfluidic channel or chamber and at least one interdigitated electrode (IDE) that can create a localized electric field below and/or within at least one fluidic channel or chamber. In some embodiments, this allows size-specific and/or size-dependent droplet manipulation.
Board of Regents, The University of Texas System (USA)
Inventor
Kelly, Ryan
Biegalski, Steven
Brownfield, Ryan
Farrar, Kraig
Gates, Tyler
Haas, Derek
Scherr, Jonathan
Shoemate, Jack
Tsvetkov, Pavel
Abstract
A method and system for calibrating nuclear instrumentation of a reactor is disclosed. The system comprises a reactor configured to operate at a low power level and an external heater configured to heat the reactor to its operating temperature and maintain the reactor in a critical state. The reactor maintains its temperature at a steady state by repeating steps of reducing the heater's power and increasing the reactor's power by changing one or more reactivity settings, wherein the reduced heater's power is compensated by using the increased power generated by the reactor itself. The nuclear instrumentation is configured to measure the reactor's output power and compare it with the calculated reactor's power. Based on the discrepancy between the calculated power and the measured power exceeds a threshold; and the nuclear instrumentation is appropriately calibrated by adjusting one or more settings.
Disclosed are RNA inhibitors, such as small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) specific for RND3, alternatively referred to as RhoE. Also disclosed are methods of treating subjects by administering RNA inhibitors. Further disclosed are methods of detecting potential modulators of RND3.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
85.
CERVICAL SPINAL FIXATION ASSEMBLY FOR LAMINAR SCREWS
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
THE TEXAS A&M UNIVERSITY SYSTEM (USA)
Inventor
Tatsui, Claudio E.
Bird, Justin E.
Rhines, Laurence D.
North, Robert Y.
Alvarez-Breckenridge, Christopher A.
Bohle, Kihoon
Mansfield, Hunter
Abstract
A spinal fixation assembly for use with a cervical fixation rod and methods of use thereof. The spinal fixation assembly can comprise a washer comprising a first side and a second side opposing the first side, the first side comprising a first set of teeth arranged longitudinally, the second side comprising a second set of teeth arranged circumferentially and a laminar wing comprising a slot configured to receive a fastener therethrough, wherein the laminar wing extends laterally from the cervical fixation rod when coupled thereto, the laminar wing adjustably coupled to the cervical fixation rod via the washer such that the first set of teeth are configured to allow a longitudinal position of the laminar wing to be adjusted relative to the cervical fixation rod and the second set of teeth are configured to allow an orientation of the laminar wing to be adjusted relative to the cervical fixation rod.
Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to a vaccine compositions and methods of vaccinating comprising: a Brucella canis comprising one or more attenuating gene knockouts; and a pharmaceutically acceptable vaccine carrier.
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventor
Kelly, Ryan
Haas, Derek
Scherr, Jonathan
Shoemate, Jack
Tsvetkov, Pavel
Biegalski, Steven
Brownfield, Ryan
Farrar, Kraig
Gates, Tyler
Abstract
A method and system for calibrating nuclear instrumentation of a reactor is disclosed. The system comprises a reactor configured to operate at a low power level and an external heater configured to heat the reactor to its operating temperature and maintain the reactor in a critical state. The reactor maintains its temperature at a steady state by repeating steps of reducing the heater's power and increasing the reactor's power by changing one or more reactivity settings, wherein the reduced heater's power is compensated by using the increased power generated by the reactor itself. The nuclear instrumentation is configured to measure the reactor's output power and compare it with the calculated reactor's power. Based on the discrepancy between the calculated power and the measured power exceeds a threshold; and the nuclear instrumentation is appropriately calibrated by adjusting one or more settings.
A method of producing a lignin composition comprising contacting a lignin obtained from a renewable resource with an aqueous fluid a plurality of times to produce a washed lignin; contacting the washed lignin with an acid under conditions suitable for formation of an acid washed lignin; contacting the acid washed lignin with one or more cellulases to form a pretreated lignin; and fermenting the pretreated lignin to form a crosslinked high molecular weight lignin. A composite material comprising a high molecular weight crosslinked lignin and at least one material selected from the group consisting of carbon fiber, polymers, a precursor for carbon-based materials, nanomaterials, cement, concrete and combinations thereof.
A metal hydride storage system (MHSS) and a method for refueling the MHSS includes obtaining a parameter vector comprising a first state of a metal hydride storage system (MHSS), and a measurable output of the MHSS; sending the parameter vector to a control algorithm, wherein the control algorithm includes a first data structure and a second data structure, wherein the first data structure corresponds to a plurality of critical regions, wherein the second data structure corresponds to a plurality of piecewise affine functions, wherein the affine functions corresponds to a control action; searching the first data structure with the parameter vector; selecting a critical region based on searching the first data structure; selecting, from the second data structure, a piecewise affine function corresponding to the selected critical region; and calculating a control action based on the affine function, where the control action comprises controlling at least one controlled parameter.
Systems and methods for automated separation and recovery of compounds from solution are disclosed herein. In some embodiments, the system can use a pump in fluid/air communication with a chromatography column to dissolve and recover astatine from a solution containing astatine, bismuth, and nitric acid. The system can be in communication with a controller that can automate and/or remotely signal each component of the system to execute the recovery without manual user inputs.
Blood coagulation testing can be performed by measuring, based on video of a blood sample flowing in a microfluidic channel, the time it takes until flow stops due to clotting. In various embodiments, such measurements are enabled by a low-cost testing system that includes a microfluidic cartridge and uses a smartphone or similar device for video acquisition, in conjunction with a lighting module for illuminating the microfluidic channel and a 3D-printed platform for holding and positioning and orienting the cartridge, lighting module, and smartphone in fixed special relation to each other.
Disclosed are example efficient circuits that produce spark discharges for hydrocarbon conversion (or treatment of other mixtures) using a high-voltage rectified DC supply to discharge a capacitor (either internal or external) across a two-electrode gap, optimized to minimize waste energy by operating in a constant current, approximately-constant current, or constant power mode. The circuits may operate off of a standard electrical supply line (e.g. 120 VAC or 240 VAC, 60 Hz, single-phase or multi-phase). The disclosed approach is scalable to any number of discharge gaps while maintaining similar pulse characteristics and electrical efficiency.
C10G 15/08 - Cracking of hydrocarbon oils by electric means, electromagnetic or mechanical vibrations, by particle radiation or with gases superheated in electric arcs by electric means or by electromagnetic or mechanical vibrations
B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
93.
MID-INFRARED WAVEGUIDE SENSORS FOR VOLATILE ORGANIC COMPOUNDS
Chalcogenide waveguides with high width-to-height aspect ratios and a smooth exposed surfaces can serve as mid-infrared evanescent-absorption-based sensors for detecting and identifying volatile organic compounds and/or determining their concentration, optionally in real-time. The waveguide sensors may be manufactured using a modified sputtering process in which the sputtering target and waveguide substrate are titled and/or laterally offset relative to each other and the substrate is continuously rotated.
In an embodiment, the present disclosure pertains to a method of reducing cytocidal activity of cells. In some embodiments, the method includes altering eukaryotic elongation factor-2 kinase (eEF-2K) in a subject and inducing a reduction of cytocidal activity of cytotoxic T cells (CTLs) in the subject. In some embodiments, the altering of eEF-2K in the subject can include a decrease of eEF-2K in the subject.
In one aspect, the disclosure relates to a universal method for biomarker extraction and detection from clinical samples using magnetic nanoparticles (MNPs) coupled with a locked aptamer-initiator approach. The MNP bound locked aptamer undergoes a conformational change in the presence of the target biomarker and the unfolded initiator triggers a hybridization chain reaction with a structurally stabilized catalytic trimeric triplex DNAzyme hairpin. Amplicons from the hybridization chain reaction can be incubated with hemin to obtain a stable triplex structure that has horseradish peroxidase-like activity in the presence of H2O2 and a substrate molecule. The intensity of the signal is directly proportional to the amount of biomarker present. Binding one or more reagents on a nanoparticle can be coupled with this approach for use in a microfluidic or paper fluidic platform. In any of these aspects, the assay can detect as low as femtogram amounts of biomarker from the clinical sample.
In an embodiment, the present disclosure pertains to a wearable sensor. In some embodiments, the wearable sensor includes a double-sided adhesive layer, a paper microfluidic layer, and an encapsulation layer. In an additional embodiment, the present disclosure pertains to a method of biochemical analysis. In general, the method includes collecting biofluid from a subject via a wearable sensor and quantifying the biofluid. In some embodiments, the wearable sensor includes a double-sided adhesive layer and a paper microfluidic layer having a microfluidic channel in a serpentine configuration. In some embodiments the microfluidic channel includes an inlet to receive the biofluid, an outlet to collect the excess biofluid, and a plurality of plasmonic sensors.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A method and system for decoding low density parity check (LDPC) codes. A method includes performing block parallel processing that initiates processing all non-zero block columns of a plurality (M) of rows of a layer of an LDPC matrix in each clock cycle, where M≤p, and p is a total number of rows in a layer of the LDPC matrix; and updating a P message responsive to determination of a final state for each row of the LDPC matrix. The LDPC matrix includes layers, each comprising a plurality (M) of rows that are processed per clock cycle. Each of the plurality of rows of each of the layers is datawise independent of the rows processed during a previous NP_MAX clock cycles and at least one row in each layer is datawise dependent on a row of an immediately preceding layer, and NP_MAX is greater than one.
H03M 13/11 - Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words using block codes, i.e. a predetermined number of check bits joined to a predetermined number of information bits using multiple parity bits
H03M 13/00 - Coding, decoding or code conversion, for error detection or error correctionCoding theory basic assumptionsCoding boundsError probability evaluation methodsChannel modelsSimulation or testing of codes
Method and systems for situational awareness are disclosed. An example method includes receiving a first set of sensor data from a plurality of internal data sources that describes geospatial locations of objects within an airspace. The method also includes receiving event data from an external data source over a network describing publicly available information affecting the airspace. The method also includes receiving a second set of sensor data from another external data source operated by a user that describes the geospatial location of a user-operated object. The method also includes generating object metadata based on the first and second sets of sensor data and the event data. The method also includes streaming at least a subset of the object metadata to the computing device of the user. The object metadata is processed to generate a real-time three-dimensional rendering of the airspace, including the objects and the user-operated object.
A method for reconstructing a three-dimensional (3D) of a sample includes displacing an outer surface of the sample at a desired sample, repeatedly activating an ultraviolet stroboscopic illuminator to produce ultraviolet excitation light at a frequency that is based on the speed of the sample, repeatedly activating a pair of laterally spaced cameras of a stereoscopic imaging unit as the outer surface of the sample is displaced to capture a plurality of 2D images of different sections of the outer surface of the sample, and reconstructing a 3D image of the sample from the plurality of 2D images of the different sections captured by the pair of cameras.
H04N 13/167 - Synchronising or controlling image signals
H04N 13/239 - Image signal generators using stereoscopic image cameras using two 2D image sensors having a relative position equal to or related to the interocular distance
H04N 13/254 - Image signal generators using stereoscopic image cameras in combination with electromagnetic radiation sources for illuminating objects
100.
RECYCLING CARBON FIBER COMPOSITES USING ELECTROMAGNETIC FIELDS
In an embodiment, the present disclosure pertains to a method of recycling that includes applying an electromagnetic field to a composite material having carbon fiber therein, heating the composition, degrading a matrix of the composite material, and recovering the carbon fiber from the composite material. In an additional embodiment, the present disclosure pertains to a method of non-contact recycling that includes applying an electromagnetic field to a composite material having carbon fiber therein with an electromagnetic applicator via at least one of direct current or alternating current, heating the composition, degrading a matrix of the composite material, and recovering the carbon fiber from the composite material. In some embodiments, the electromagnetic field is applied in a non-contact manner. In some embodiments, the heating is locally induced heating that includes increasing the temperature inside the composite material via an inside-out method thereby initiating pyrolysis within the composite material.
B29K 105/08 - Condition, form or state of moulded material containing reinforcements, fillers or inserts of continuous length, e.g. cords, rovings, mats, fabrics, strands or yarns
