The present invention relates to a method of diagnosis of primary headache. More particular, the invention relates to a method of differentiating between primary and secondary headache in a human subject by applying a biomarker for primary headache.
The present invention relates to a method of diagnosis of primary headache. More particular, the invention relates to a method of differentiating between primary and secondary headache in a human subject by applying a biomarker for primary headache.
In a particular aspect, the invention relates to a method for the diagnosis of migraine. In one particular aspect the invention relates to the field of theranostic and personalized medicine.
The present invention relates to a method of diagnosis of primary headache. More particular, the invention relates to a method of differentiating between primary and secondary headache in a human subject by applying a biomarker for primary headache. In a particular aspect, the invention relates to a method for the diagnosis of migraine. In one particular aspect the invention relates to the field of theranostic and personalized medicine.
The present invention relates to dosage units of oral films for the administration of active pharmaceutical ingredients (API), such as analgesics, relaxants, anxiolytics, sedatives, hypnotics, narcotics, anesthetics and/or other API with peripheral and/or central nervous effects, in particular for use in the treatment of pain, metabolic disorders and diseases of the central nervous system (CNS). More particular the invention relates to dosage units of oral films comprising relaxants, anxiolytics, sedatives, hypnotics, narcotics, anesthetics and/or analgesics prone to misuse and abuse, such as overdosing. More particular, the invention relates to dosage units of oral films comprising propofol. In a further aspect, the invention relates to dosage units of oral films comprising propofol for use in the treatment of a subject suffering from migraine.
The invention pertains to a pharmaceutical preparation comprising an active pharmaceutical ingredient (API) and a film for use in the prophylactic or therapeutic treatment of a subject by dermal administration, wherein the API is deposited onto the film.
The present invention relates to a topical composition for delivering API. In at least one embodiment, the composition comprises the pharmaceutically active ingredient, in particular ropivacaine, and/or a salt thereof; at least one adhesive material; and at least one backing material; and wherein, after application of the topical composition to keratinous materials of a subject, a pharmaceutically effective amount of the pharmaceutically active ingredient, in particular ropivacaine, permeates into the subject for greater than 12 hours while the topical composition remains adhesive to the keratinous material. A method of making the topical composition, and a method of continuous treatment of pain using the topical composition are also disclosed. Furthermore, a topical composition delivering at least one pharmaceutically active ingredient or salts thereof comprising the at least one pharmaceutically active ingredient or salts thereof; at least one adhesive material; at least one backing material; and at least one hydrophilic polymer in an amount ranging from 5% (w/w)-10% (w/w); wherein, after application of the topical composition to keratin material of a subject, the adhesivity of the topical composition is reduced while wearing, such that after 24 hours an external force no greater than 2.4 N is required to remove the topical composition from the keratin material.
The invention relates to a transdermal therapy system (TTS) for the administration of rotigotine, which comprises at least partially dissolved rotigotine and at least a hygroscopic polymer or copolymer in the central layer.
The invention relates to an at least three-layer transdermal therapy system (TTS) which contains, in particular, rotigotine as an active ingredient. The TTS comprises an active substance-containing central layer which has at least one hygroscopic polymer or copolymer, an inner, substance-permeable layer and an outer layer.
Method for producing and monitoring oral active ingredient films with a base to which a solution containing at least one active ingredient is applied, the method comprising the steps: • metering and mixing the base formulation, • coating the base formulation onto a substrate, so that a strip results • if necessary, drying the base formulation strip coated on the substrate • printing a colorant solution containing at least one active ingredient onto the upper side of the base formulation strip according to the flexographic printing method, • drying the base formulation strip coated on the substrate together with the printed active ingredient solution, • penetrating the base formulation strip coated on the substrate together with the printed active ingredient solution from the upper and/or lower side by means of radiation from a radiation source, • measuring the transmission of the penetrating radiation by means of at least one reception unit on the opposite side of the base formulation strip coated on the substrate together with the printed active ingredient solution.
It has been found that phenyl carbamates, in particular Rivastigmine, can be formulated as a stable TTS by using a monolayer poly alkyl (meth)acrylates, wherein the poly alkyl (meth)acrylates are substantially free of free carboxylate groups.
A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
10.
ORODISPERSIBLE FILMS FOR THE MANUFACTURING OF INDIVIDUALISED MEDICINE OR FOR LARGE SCALE PRODUCTION
The present invention pertains to oral applicable therapeutic dosage forms, in particular to orodispersible films. The present invention especially is directed to orodispersible films comprising a base layer substantially free of therapeutically active agents and a top layer comprising the desired therapeutically active agents. The present invention also concerns suitable base layers for such orodispersible films as well as therapeutical uses thereof and methods for manufacturing them.
Orally disintegrating film dosage forms for delivering active pharmaceutical agents, methods of formulating the dosage forms to retard absorption through the oral mucosa, and methods of using the dosage forms for the treatment of various medical conditions are provided.
The invention relates to a laser-writable film having a substrate arrangement and a functional layer arrangement, the functional layer arrangement being configured as a hot laminate or as a hot stamping layer arrangement, and being connected to the substrate arrangement by hot laminating or hot stamping, and the functional arrangement being writable via laser irradiation, characterized in that the functional layer arrangement can be removed at least partially via laser irradiation, and forms the lettering by means of the partial removal.
B44C 1/22 - Removing surface-material, e.g. by engraving, by etching
B41M 5/24 - Ablative recording, e.g. by burning marksSpark recording
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
The invention relates to an electrode (100) for detecting electric signals on a body surface (4), comprising a carrier layer (2) facing away from the body and an electrolyte layer (3) facing the body, said layer being arranged on the carrier layer (2), wherein the carrier layer (2) has an opening (7) into which a pin-and-socket connector (5) can be inserted such that the pin-and-socket connector forms an electric contact with the electrolyte layer (2).
The invention relates to a carrier film, which is suited particularly for fibrillation, wherein the carrier film is stretched in the longitudinal direction at a stretch ratio of at least 1:7, a migratable, particularly not cross-linked silicon is introduced in the carrier film, and the carrier film is optionally provided on one side or both sides with an adhesive compound.
Disclosed is an adhesive tape comprising a backing which is composed of one or several backing foils. An adhesive material is at least partially applied to at least one side of the backing. Said adhesive tape is characterized in that at least one of the backing foils contains at least one propylene homopolymer, copolymer, or terpolymer while carbon nanotubes (CNT) are provided in at least one of the backing foils.
Heat-activable adhesive tape particularly for producing and further processing electronic components and conductor tracks, with an adhesive composed at least of a) a polyamide having terminal amino and/or acid groups, b) an epoxy resin, c) a compound having a long apolar chain with at least 6 carbon atoms and at least one reactive end capable of reacting with the epoxy resins, d) if desired, a plasticizer, the polyamide reacting with the epoxy resin at temperatures of at least 150°C, and the ratio in weight fractions of a) to b) lying between 50:50 to 99:1.
Heat-activable adhesive tape particularly for bonding electronic components and conductor tracks, with an adhesive composed at least of a) an acid-modified or acid anhydride-modified vinylaromatic block copolymer, b) an epoxide compound and c) a metal chelate.
Heat-activable adhesive tape particularly for producing and further processing electronic components and conductor tracks, with an adhesive composed at least of a) a polyamide having terminal amino and/or acid groups, b) an epoxy resin, c) if desired, a plasticizer, the polyamide reacting with the epoxy resin at temperatures of at least 150°C, and the ratio in weight fractions of a) to b) lying between 50:50 to 99:1.
For the production of a double-sided pressure-sensitive adhesive tape, having a closed and open side, possessing a carrier film (e) provided on both sides with a pressure-sensitive adhesive layer (c, c'), the carrier film (e) being a filmlike carrier film not based on rubber, and there being at least one release film located on the closed side, on the one pressure-sensitive adhesive layer (c), it is envisaged that, from the melt, two identical or different pressure-sensitive adhesives for the pressure-sensitive adhesive layers (c, c'), a film-forming polymer for the carrier film (e), and a film-forming polymer for the release film be formed, that these components be combined to form a composite, and that the pressure-sensitive adhesives be crosslinked by means of physical and/or radiation-chemical treatment.
A heat-activatedly bondable, substantially two-dimensional (旜2D”) diecutting element having a carrier, a first adhesive coating and a second adhesive coating is presented, its carrier taking the form of a carrier film having a first side and a second side, its first adhesive coating being disposed on the first side of the carrier film and comprising at least one heat-activable adhesive, and its second adhesive coating being disposed on the second side of the carrier film and comprising at least one heat-activable adhesive. The carrier film here has, over its two-dimensional extent, a multiplicity of openings which extend continuously through the carrier film from the first side of the carrier film through to the second side of the carrier film.
The invention relates to a peelable adhesive strip which is coated with a pressure-sensitive adhesive at least one side. Said adhesive strip is constituted of the following layers: a core layer having an elongation at tear of at least 300%, an external carrier layer having an elongation at tear of not more than 120% and at least some sections of which are connected to the core layer in such a manner that it becomes detached from the core layer when the same is stretched, a first adhesive layer at least some sections of which are applied to the side of the external carrier layer and which is opposite the side connected to the core layer.
Method for fastening of a component on a joining partner (3) to be enameled, wherein a section of a heat activated adhesive film (1) is heated, so that the adhesive film does not reach a complete cross-linked state, the component (2) being fastened with the section of the not completely cross-linked heat activated adhesive film on the joining partner, the joining partner being enameled together with the fastened component thereon, the enameled joining partner being dried with the fastened component thereon in a thermal drying, wherein the thermal energy leads to a complete cross-linking of the heat activated adhesive film, so that the component is permanently fastened on the joining partner.
The invention relates to the self-adhesive material of hydrogenated block copolymers or a mixture thereof, comprising polymer blocks of vinyl aromatics (A-blocks) and such made by polymerization of 1,3 dienes (B-blocks), mixing the self-adhesive material with 10 to 80 parts per weight, preferably with 10 to 40 parts per weight polyisobutylene with an average molecular weight Mw in relation to 100 parts by weight Mw of the blockcopolymeres.
C09J 153/02 - Vinyl aromatic monomers and conjugated dienes
C09J 153/00 - Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsAdhesives based on derivatives of such polymers
C08L 53/02 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers of vinyl aromatic monomers and conjugated dienes
C08L 53/00 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers
C09J 123/10 - Homopolymers or copolymers of propene
24.
SELF-ADHESIVE MATERIAL OF HYDROGENATED BLOCK COPOLYMERS AND PRODUCTIVE FILM FOR SMOOTH AND ROUGH SURFACES PRODUCED THEREOF
The invention relates to the self-adhesive material of hydrogenated block copolymers or a mixture thereof, comprising polymer blocks of vinyl aromatics (A-blocks) and such made by polymerization of 1,3 dienes (B-blocks), wherein the self-adhesive material is mixed with 25 to 100 parts per weight of polyisobutylene with an average molecular weight Mw > 200 000 g/mol, 3 to 40 phr (per hundred rubber = in relation to the blockcopolymeres) adhesive resin and 0,1 to 5 phr light protecting agent in relation to 100 parts per weight of the blockcopolymeres.
The invention relates to a method for producing stampings from thermally activatable adhesive films, said method being characterised in that a) a thermally activatable adhesive material is first applied to a first carrier material, and b) the thermally activatable layer of adhesive material is laminated onto a temporary carrier material ('release liner') under the action of heat, during a subsequent step. The release liner comprises at least one surface based on polyolefins, said surface being non-tacky at room temperature and activatable under the action of heat in such a way that it has adhesive properties. The method is also characterised in that c) the thermally activatable layer of adhesive material on the release liner is subjected to a stamping process.
The invention relates to an adhesive film comprising at least one carrier film and at least one layer of an adhesive material. The invention is characterised in that the carrier film has a tensile strength of at least 50 MPa, measured according to ASTM D882, a haze value of no more than 3 %, measured according to ASTM D1003, and a transmission of at least 80 %, measured according to ASTM D1003, in light with a wavelength of 550 nm; and in that the adhesive film has a transmission of at least 70 %, measured according to ASTM D1003. The invention also relates to the use of a corresponding single-sided or double-sided adhesive film, as an anti-splinter cover for glass windows, especially for electronic consumer items.
Pressure-sensitive adhesive based on a mixture of a chemically cross-linked polyurethane and at least one hydrocarbon resin, the chemically cross-linked polyurethane being composed of the following starting materials, which are reacted catalytically with one another in the ratios given in the presence of the hydrocarbon resin or resins: a) at least one aliphatic or alicyclic polyisocyanate, the functionality of which is less than or equal to three and preferably two, b) a combination of at least one polypropylene glycol diol and one polypropylene glycol triol, the ratio of the number of isocyanate groups to the total number of hydroxyl groups being between 0.8 and 1.15 and preferably between 0.95 and 1.05, the ratio of the number of hydroxyl groups of the diol component to the number of hydroxyl groups of the triol component being between 0.8 and 9.0 and preferably between 1.0 and 4.0, the diols and triols being selected and combined alternatively as follows: diols with a number-average molecular weight Mn of less than or equal to 1000 are combined with triols, the number-average molecular weight Mn of which is larger than or equal to 1000 and preferably larger than or equal to 3000, or diols with a number-average molecular weight of more than 1000 are combined with triols, the number-average molecular weight of which is smaller than 1000, characterized in that at least one hydrocarbon resin is a monomer resin of the styrene / α-methylstyrene type with a number-average molecular weight Mn of between 200 and 6000 and preferably between 500 and 2000, the proportion by weight of the resin in the mixture being more than 0% and extending at most up to and including 55%.
The invention relates to a sheet-like material, particularly for use in a diagnostic strip, comprising a carrier material having a one- or two-sided layer, which comprises at least a surfactant which - is nonionic, - has a critical micelle concentration (CMC) of 0.1 g/l or lower and - has a surface tension of the 0.1% by weight aqueous solution of < 30 mN/m.
The invention relates to the use of a halogen-free film composed of polyolefins in a single-sided adhesive masking tape used preferably in the two-tone painting of plastic components for external mounting, the film being composed of a mixture composed of a polypropylene or a polypropylene copolymer and of a further polymer, selected from the group of the polyethylenes or ethylene copolymers, the film, before or after coating with the adhesive, being irradiated with electron beams, with a dose between 5 and 100 kGy (kilograys), and the weight fraction of polypropylene or of polypropylene copolymer being at least 20%, based on the entirety of the polyolefins.
Bubble-free bonding adhesive coating with a bonding material and a channel element, whereby the channel element is formed, at least temporarily, with a fitted cavity for the transportation of fluids, the channel element hereto has one thread entity with at least one thread, the channel element and the thread entity are fundamentally parallel to the extent of the surface and aligned with the adhesive coating, and a section of the surface of the thread entity forms a section of the surface of that side of the adhesive coating that is the bubble-free bonding adhesive surface of the adhesive coating.
Pressure-relief valve (10) for a packaging container (1) having a base plate (11) which is fastened to the wall (2) of the packaging container (1) and has a central valve hole (15) which covers through holes (3) in the wall (2) of the packaging container (1), and having a lid film (13) which is fastened on the base plate (11), wherein a valve diaphragm (12) which releases a channel, covers the valve hole (15) and bears sealingly on the base plate (11) in the closed position of the pressure-relief valve (10) is provided between the base plate (11) and the lid film (13), characterized in that the valve diaphragm (12) has a thickness of at least 10 &mgr;m, preferably of from 20 to 70 &mgr;m, a film made preferably from PE, PP or PET is used as material for the valve diaphragm (12), the base plate (11) has a thickness of at least 100 &mgr;m, preferably of from 150 to 250 &mgr;m, and the lid film (13) has a thickness of at least 100 &mgr;m, preferably of from 150 to 250 &mgr;m.
The invention relates to adhesive masses containing at least one electroluminescent additive, single and double-sided adhesive strips which are provided with adhesive masses of said type, and to the use of said adhesive masses for sticking together electronic components.
Adhesive tape, which is suitable for the flying roll change of flat web material that is wound upon rolls and has nonpolar surfaces and which comprises an upper self-adhesive compound (1, 11), a splittable backing (2, 12) and a lower self-adhesive compound (3, 13) on the lower side of the splittable backing (2, 12), wherein a silicone-free self-adhesive compound with an adhesive strength on a polyethylene adherend surface of 1.5 N/cm or more (measuring method tesa test A) and a tackiness corresponding to a rolling distance of 200 mm or less (measuring method tesa test D) is used as the upper self-adhesive compound (1, 11) and a self-adhesive compound with an adhesive strength on a polyethylene adherend surface of 1.5 N/cm or more (measuring method tesa test A) and a complex viscosity of 10,000 Pa s or more at 1 rad/s and 40°C (measuring method tesa test F) is used as the lower self-adhesive compound (3, 13).
The invention relates to a label from at least one inflexible carrier layer and an adhesive layer. Said layer is characterized in that a reversibly flexible compensation layer is interposed between the carrier layer and the adhesive layer and is solid at temperatures up to 50 °C and softens or begins to melt at higher temperatures and is capable of balancing out occurring stress.
The invention relates to a label with improved antiforgery security, comprising an adhesive layer applied to the lower face of the support layer. The invention in is characterized in that in or on the bare face of the adhesive layer a plurality of discrete inclusions are present which contain at least one reversibly detective additive. When the label is bonded to a base, the discrete inclusions are forced into the adhesive mass to such a degree that the layers of the label present above the inclusions are deformed, thereby forming haptically distinguishable and optically visible bumps in the surface of the upper support layer.
The invention relates to a label with increased antiforgery security comprising a support laminate that is composed of at last two support layers, an adhesive layer being present on one of the bare faces of the support layers. The invention is characterized in that a separating layer, not applied to the entire surface, is present between the support layers of the support laminate, said separating layer reducing the interlaminar adhesion between the two support layers due to the fact that the adhesive forces of the separating layer in relation to at least one support layer are lower than the adhesive forces of the other support layer.
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