Tel Hashomer Medical Research Infrastructure and Services Ltd.

Israel

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2025 May 1
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IPC Class
A61B 5/00 - Measuring for diagnostic purposes Identification of persons 35
A61P 35/00 - Antineoplastic agents 23
A61F 9/007 - Methods or devices for eye surgery 22
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids 17
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer 17
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1.

Devices and methods for treating lung diseases

      
Application Number 17239880
Grant Number 12296094
Status In Force
Filing Date 2021-04-26
First Publication Date 2025-05-13
Grant Date 2025-05-13
Owner
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
  • Ramot at Tel-Aviv University Ltd. (Israel)
Inventor
  • Ashkenazi, Moshe
  • Sokol, Gil
  • Efrati, Ori
  • Mashiach, Itzik
  • Sverdlov, Diana
  • Shtayman, Ortal
  • Ben Avi, Imry
  • Sorkin, Daniel

Abstract

Pulmonary treatment methods and systems. During pulmonary treatment breath cycles, a hold period of elevated inspiration pressure may promote lung region filling (and potentially recruitment) via collateral airways. Expectoration is promoted by dropping from the inspiration pressure to an undershoot pressure; de-recruitment (e.g., by airway collapse) is mitigated by raising the undershoot pressure to a positive expiratory pressure (PEP) during expiration phase. Breath cycles with a period of post-PEP suction may also be administered. Respiratory therapy systems may be programmed or re-programmed to administer this pressure protocol. In some embodiments, a system includes a hand-held unit including a patient mouthpiece, a base unit which provides pressurized gas to the mouthpiece, an electronically controllable valve in the hand-held unit for providing therapy maneuvers such as PEP (Positive Expiratory Pressure) through the mouthpiece, and a computing unit which instructs the hand-held unit to perform therapy maneuvers.

IPC Classes  ?

  • A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
  • A61M 16/20 - Valves specially adapted to medical respiratory devices

2.

METHODS AND DEVICES SUITABLE FOR IMAGING BLOOD-CONTAINING TISSUE

      
Application Number 18583445
Status Pending
Filing Date 2024-02-21
First Publication Date 2024-08-15
Owner
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
  • RAMOT AT TEL AVIV UNIVERSITY LTD. (Israel)
Inventor
  • Kostenich, Genady
  • Orenstein, Arie
  • Belkin, Michael

Abstract

Disclosed are methods and devices useful for imaging blood-containing tissue, for example for angiography, especially retinal angiography, whereby an image is generated by dividing pixels of an image acquired at some wavelength range by corresponding pixels of an image acquired at a different wavelength range. In some embodiments, a first wavelength range includes predominantly light having wavelengths between about 400 nm and about 620 nm and a second wavelength range includes predominantly light having wavelengths between about 620 nm and about 800 nm.

IPC Classes  ?

  • A61B 5/026 - Measuring blood flow
  • A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
  • A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

3.

ENRICHED PELARGONIUM GRAVEOLENS EXTRACTS FOR THE TREATMENT OF TRAUMATIC BRAIN INJURIES

      
Application Number IL2024050049
Publication Number 2024/154119
Status In Force
Filing Date 2024-01-14
Publication Date 2024-07-25
Owner
  • THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) (Israel)
  • TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Elmann, Anat
  • Liraz Zaltsman, Sigal
  • Dudai, Nativ

Abstract

Pelargonium graveolensPgPg oil) enriched with a monoterpene or monoterpenoid.

IPC Classes  ?

  • A23L 27/12 - Natural spices, flavouring agents or condimentsExtracts thereof from fruit, e.g. essential oils
  • A61K 36/185 - Magnoliopsida (dicotyledons)
  • A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
  • A23L 33/115 - Fatty acids or derivatives thereofFats or oils
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
  • A23G 9/52 - Liquid productsSolid products in the form of powders, flakes or granules for making liquid products

4.

VALVE FRAME FOR PROSTHETIC TRICUSPID VALVE

      
Application Number 17906332
Status Pending
Filing Date 2022-06-16
First Publication Date 2024-06-27
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Orlov, Boris
  • Raanani, Ehud

Abstract

Apparatus and methods are described for use with a native tricuspid valve of a heart of a mammalian subject. A valve frame (22) includes a valve-frame body (32) that is configured to support prosthetic valve leaflets (20) within the native tricuspid valve. Chord-recruiting arms (30) are configured to extend from the valve-frame body at circumferential regions corresponding to the anterior leaflet and the posterior leaflet of the native tricuspid valve. An anchoring arm (28) is configured to extend from the valve-frame body at a circumferential region corresponding to the septal leaflet of the native tricuspid valve, the anchoring arm (28) being longer than each of the chord-recruiting arms (30). Other applications are also described.

IPC Classes  ?

5.

MACHINE LEARNING MODELS FOR PREDICTION OF UNPLANNED CESAREAN DELIVERY

      
Application Number 18280254
Status Pending
Filing Date 2022-03-03
First Publication Date 2024-05-23
Owner Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Tsur, Abraham
  • Meyer, Raanan
  • Eilenberg, Roni

Abstract

There is provided a computer implemented method of training a machine learning model for prediction of unplanned Cesarean Delivery (uCD), comprising: creating or receiving a multi-record training dataset, wherein a record comprises: at least one fetal biometric parameter of a sample fetus obtained by an ultrasonography device, at least one personal parameter of a sample mother of the sample fetus, and a ground truth indicating whether a birth of the sample fetus by the sample mother was a uCD, and training the machine learning model on the multi-record training dataset for generating an outcome indicating likelihood of uCD for a target mother in response to an input of at least one fetal biometric parameter of a target fetus of the target mother and at least one personal parameter of the target mother.

IPC Classes  ?

  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 8/08 - Clinical applications
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

6.

METHOD AND SYSTEM FOR ACCELERATING MAGNETIC RESONANCE IMAGING

      
Application Number IL2023051069
Publication Number 2024/079732
Status In Force
Filing Date 2023-10-11
Publication Date 2024-04-18
Owner
  • RAMOT AT TEL-AVIV UNIVERSITY LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Hod, Gali
  • Kiryati, Nahum
  • Mayer, Arnaldo
  • Nelkenbaum, Ilya
  • Nazarov, Alexander

Abstract

A method of magnetic resonance imaging (MRI) comprises: acquiring a first MRI scan having a first type of MR image contrast, and a second MRI scan having a second type of MR image contrast. The acquisition ensures that the two MRI scans are blurred along different phase encoding directions. The method also comprises feeding a machine learning procedure trained to deblur MR images with input data describing the first and the second MRI scans, and receiving from an output of the machine learning procedure output data corresponding to a deblurred MR image.

IPC Classes  ?

  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
  • G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
  • G06T 5/73 - DeblurringSharpening

7.

GATA6-AS1 lncRNA FOR USE IN THERAPY

      
Application Number 18310044
Status Pending
Filing Date 2023-05-01
First Publication Date 2024-02-29
Owner
  • Tel Hashomer Medical Research Infrastructure and Services Ltd. (Israel)
  • Ramot At Tel-Aviv University Ltd. (Israel)
Inventor
  • Haberman Ziv, Yael
  • Sosnovski, Katya Elinoy
  • Braun, Tzipi

Abstract

The present invention provides methods of treating or preventing chronic intestinal inflammation and/or inflammatory bowel disease (IBD) comprising administering GATA6-AS1 lncRNA to a patient in need thereof.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

8.

AURICULAR RECONSTRUCTION USING 3D PRINTED AUTOLOGOUS CARTILAGE TISSUE

      
Application Number 18270852
Status Pending
Filing Date 2022-01-04
First Publication Date 2024-02-29
Owner
  • Technion Research & Development Foundation Limited (Israel)
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Levenberg, Shulamit
  • Landau, Shira
  • Duvdevani, Shay

Abstract

An aspect of some embodiments of the invention relates to methods of manufacturing a 3D printed implant, comprising printing a mold of a scaffold, generating said scaffold from said mold, seeding cells on said scaffold, where said generating said scaffold comprises generating parts of said scaffold with different levels of stiffness.

IPC Classes  ?

9.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF UROTHELIAL CANCER

      
Application Number 18266029
Status Pending
Filing Date 2021-12-08
First Publication Date 2024-02-08
Owner
  • The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (Israel)
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Koltai, Hinanit
  • Anis, Omer

Abstract

Compositions capable of reducing viability, initiating apoptosis, inducing cell cycle arrest and/or reducing migration of urothelial carcinoma cells and methods of use thereof are provided. The compositions and uses thereof comprise cannabinoids.

IPC Classes  ?

  • A61K 31/00 - Medicinal preparations containing organic active ingredients
  • A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
  • A61P 35/00 - Antineoplastic agents

10.

COMPOUNDS FOR TREATING EYE DISEASES AND DISORDERS

      
Application Number 18256747
Status Pending
Filing Date 2021-12-09
First Publication Date 2024-02-01
Owner
  • The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organiza (Israel)
  • Tel Hashomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Elmann, Anat
  • Rotenstreich, Ygal
  • Sher, Ifat

Abstract

The invention concerns 3,5,4′-trihydroxy-6,7,3′-trimethoxyflavone (TTF) or a pharmaceutically acceptable salt or solvate thereof for use in treating, preventing, or ameliorating an eye disease or disorder, or for providing adjunct treatment to an ocular therapeutic procedure. The invention also concerns ophthalmic compositions comprising TTF.

IPC Classes  ?

  • A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
  • A61P 27/02 - Ophthalmic agents
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 36/28 - Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea

11.

URINE-DERIVED EPITHELIAL CELL CULTURES, NEPHROSPHEROIDS DERIVED THEREFROM AND METHODS OF PRODUCING AND USING SAME

      
Application Number 18249469
Status Pending
Filing Date 2021-10-19
First Publication Date 2023-12-07
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Dekel, Benjamin
  • Omer, Dorit
  • Harari-Steinberg, Orit

Abstract

A nephrospheroid comprising urine-derived epithelial cells, the nephrospheroid is capable of forming a tubular nephric tissue upon transplantation. Also provided are methods of producing the nephrospheroid and using same.

IPC Classes  ?

  • A61K 35/22 - UrineUrinary tract, e.g. kidney or bladderIntraglomerular mesangial cellsRenal mesenchymal cellsAdrenal gland
  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

12.

TREATMENT OF RETINAL DISORDERS

      
Application Number 18144968
Status Pending
Filing Date 2023-05-09
First Publication Date 2023-11-09
Owner Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Chapman, Joab
  • Shavit Stein, Efrat
  • Rotenstreich, Ygal
  • Sher Rosenthal, Ifat

Abstract

Ophthalmic formulations comprising a PAR1 antagonist and/or an agent that interferes with an interaction of PAR1 and a protease (e.g., thrombin), and an ophthalmically acceptable carrier, and uses thereof in treating or preventing retinal pathologies such as retinal degeneration, are provided. The agent can be, for example, a peptide conjugate represented by Formula I, as defined in the specification.

IPC Classes  ?

13.

METHOD AND SYSTEM FOR IMAGING EYE BLOOD VESSELS

      
Application Number 18223106
Status Pending
Filing Date 2023-07-18
First Publication Date 2023-11-09
Owner
  • Ramot at Tel-Aviv University Ltd. (Israel)
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Rotenstreich, Ygal
  • Sher Rosenthal, Ifat
  • Suchowski, Haim
  • Mrejen, Michael
  • Katz, Shahar

Abstract

A method of diagnosing a condition of a subject, comprises: receiving image data of an anterior of an eye of the subject, and analyzing the image data to detect at least one of: flow of individual blood cells in libmal or conjunctival blood vessels of the eye, morphology of limbal or conjunctival blood vessels. The method also comprises determining the condition of the subject based on the detection(s).

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 5/026 - Measuring blood flow
  • A61B 3/11 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring interpupillary distance or diameter of pupils

14.

DELAYING PRE-TERM BIRTH

      
Application Number 18212790
Status Pending
Filing Date 2023-06-22
First Publication Date 2023-10-19
Owner
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
  • The Trendlines Group Ltd. (Israel)
Inventor
  • Tsur, Abraham
  • Farber, Sharon
  • Mashiach, Roy
  • Hazan, Yosef
  • Shashar, David
  • Shenhav, Avshalom

Abstract

A device for retarding birth including an upper ring for surrounding a cervix, an anchoring component for anchoring the device, and an elastic component for attaching the upper ring to the anchoring component, wherein the elastic component pushes the upper ring and the anchoring component apart. A device for retarding birth including a sleeve for surrounding a cervix along a greater portion of a length of the cervix, a support strip on the sleeve directed along an axis of the sleeve, and a ring at least partially around the sleeve, in which when a top of the sleeve is pushed to expand radially, the support strip pivots on the ring, such that an end of the support strip near the top of the sleeve moves radially outward, and an end of the support strip near the bottom of the sleeve moves radially inward. Related apparatus and methods are also described.

IPC Classes  ?

  • A61B 17/122 - Clamps or clips, e.g. for the umbilical cord
  • A61B 17/42 - Gynaecological or obstetrical instruments or methods
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61F 6/08 - Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception
  • A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body

15.

A FALLOPIAN TUBE RETRIEVABLE DEVICE

      
Application Number 17927987
Status Pending
Filing Date 2021-05-27
First Publication Date 2023-10-05
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Cohen, Shlomi
  • Ben David, Tamir
  • Sivan, Tovy

Abstract

A contraceptive device is provided including an occluding component for deployment in a tubal lumen of a reproductive organ. The device includes an expandable frame reversibly expandable from a collapsed state to an expanded state and a barrier supported by the expandable frame. In the expanded state the barrier is disposed between the expandable frame and walls of the lumen to inhibit in-growth of cellular material into and onto the occluding component, and additionally the barrier is urged against walls of the tubal lumen to define at least two tube lumen sealing areas, disposed perpendicular to a longitudinal axis of the walls of the tube lumen such that (i) the expandable frame is disposed between the two tubal lumen sealing surface, and (ii) passage of reproductive cells through the expandable frame, and through the tube lumen is blocked, therefore, creating a the complete blockage for liquids from a first part of the tube to a second part of the tube, downstream the first part. Other applications are also described.

IPC Classes  ?

  • A61F 6/22 - Vas deferens occludersFallopian occluders implantable in tubes

16.

INJECTION DEVICE WITH BOTH LINEAR AND ROTARY INDEPENDENT MOTOR DRIVES

      
Application Number 18021622
Status Pending
Filing Date 2021-08-17
First Publication Date 2023-09-28
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor Rotenstreich, Ygal

Abstract

Embodiments pertain to an apparatus for injecting a medicament into a tissue, the apparatus comprising: a rotary motion drive having a motion drive rotary axis and which is configured to receive a needle and operable to rotate the needle about the motion drive rotary axis; and a linear motion drive comprising a drive screw and configured to translate the needle selectively in either proximal and distal direction along a translation axis, and further configured such that, when the apparatus is operably engaged with the tissue, the drive screw remains translationally stationary relative to the tissue during operation of the rotation motion drive to longitudinally translate the needle; and wherein the rotary motion drive and the linear motion drive are independently operatable.

IPC Classes  ?

  • A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
  • A61F 9/007 - Methods or devices for eye surgery
  • A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically

17.

MARKER FOR RESPONSE TO PD-1/PD-L1 IMMUNOTHERAPY

      
Application Number 18130852
Status Pending
Filing Date 2023-04-04
First Publication Date 2023-09-14
Owner
  • 4C BIOMED LIMITED (United Kingdom)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Greenberg, Eyal
  • Galore-Haskel, Gilli
  • Merhavi-Shoham, Efrat
  • Markel, Gal

Abstract

Methods of determining suitability of a subject to be treated with a PD-1/PD-L1 based immunotherapy, comprising receiving a sample from the subject and determining HVEM levels in the sample, wherein expression of HVEM above a predetermined threshold indicates the subject is suitable to be treated by the immunotherapy or of determining suitability of a subject non-responsive to a PD-1/PD-L1 based immunotherapy to be treated by an HVEM based immunotherapy, comprising receiving a sample from the subject and determining T cell levels in the sample, wherein T cell levels above a predetermined threshold indicates the subject is suitable to be treated by the HVEM based immunotherapy are provided.

IPC Classes  ?

  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

18.

METHOD OF DIAGNOSING BREAST CANCER

      
Application Number 18128260
Status Pending
Filing Date 2023-03-30
First Publication Date 2023-08-31
Owner
  • Yeda Research and Development Co. Ltd. (Israel)
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Lev, Sima
  • Vinik, Yaron
  • Ortega, Francisco Gabriel
  • Gutman Md, Mordechai

Abstract

A method of diagnosing breast cancer is disclosed. The method comprises lysing extracellular vesicles of a subject to generate a composition comprising components of extracellular vesicles; measuring the amount of MEK1 in the composition; and diagnosing the subject with breast cancer when a level of said MEK1 in said composition is above a predetermined threshold. Kits for breast cancer diagnosis are also disclosed.

IPC Classes  ?

  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
  • G01N 1/34 - PurifyingCleaning

19.

AN OCULAR ACOUSTIC DEVICE AND A METHOD THEREOF

      
Application Number 18005406
Status Pending
Filing Date 2021-07-14
First Publication Date 2023-08-24
Owner
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • BAR ILAN UNIVERSITY (Israel)
Inventor
  • Skaat, Alon
  • Leshno, Ari
  • Kenigsberg, Avraham
  • Shpaisman, Hagay

Abstract

The present invention enables assisting in manipulation and movement of intraocular particles in order to treat various ocular conditions. It enables controlling intra-ocular particles using acoustic wave forces. The novel technique of the present invention utilizes acoustic radiation forces for non-invasive control over movement of the pathologic intraocular particles, preventing them from unwanted accumulation and obstruction of intraocular structures, or causing visual disturbances. Acoustic forces can be harnessed to non-invasively organize various types of endogenous and exogenous particles within the anterior chamber of the eye, without any sign of tissue damage.

IPC Classes  ?

20.

LUNG AIRWAY CLEARANCE

      
Application Number 17919770
Status Pending
Filing Date 2021-04-22
First Publication Date 2023-07-20
Owner Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Ashkenazi, Moshe
  • Sokol, Gil
  • Efrati, Ori

Abstract

A system for providing treatment adapted to clear lung airways, the system including at least one pressure applicator adapted, when activated, to apply pressure at at least one specific location on a torso of a patient, and, when deactivated, to release the pressure, a sensor for sensing a signal associated with the patient, and, a controller, in communication with the sensor, adapted to analyze the signal and to control activation and deactivation of the at least one pressure applicator based, at least in part, on analyzing the signal. Related apparatus and methods are also described.

IPC Classes  ?

  • A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

21.

TARGETING G3BP AGGREGATION TO PREVENT NEURODEGENERATION

      
Application Number 17989817
Status Pending
Filing Date 2022-11-18
First Publication Date 2023-06-22
Owner
  • University of South Carolina (USA)
  • Ramot at Tel-Aviv University Ltd. (Israel)
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Kar, Amar N.
  • Sahoo, Pabitra
  • Twiss, Jeffery
  • Mcgill, Sean
  • Perlson, Eran
  • Altman, Topaz
  • Ionescu, Ariel Razvan
  • Gradus-Pery, Tal
  • Dori, Amir

Abstract

Testing peptides in in vitro models of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Frontotemporal dementia, Amyotrophic lateral sclerosis, to evaluate systems and methods of treatment therefore.

IPC Classes  ?

  • A61K 38/46 - Hydrolases (3)
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

22.

Device and method for creating a channel in soft tissue

      
Application Number 18098291
Grant Number 11974947
Status In Force
Filing Date 2023-01-18
First Publication Date 2023-05-18
Grant Date 2024-05-07
Owner
  • SANOCULIS LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND S (Israel)
Inventor
  • Lavi, Gilad
  • Glovinsky, Yoseph
  • Shmukler, Vadim
  • Israeli, Nir

Abstract

Medical devices and methods for removing a predetermined portion of soft tissue from a target tissue layer, thereby creating a channel between two side walls of the target tissue layer, are described. The medical device is a cutting tool comprising: an elongated round body extending along a longitudinal axis and having a uniform outer cross-section at a proximal side thereof; a cutting portion at a distal side of the elongated body, comprising at a distal end thereof a cutting edge of a first cross-section being smaller than said outer cross-section, and a distally and continuously decreasing outer cross-section; and a chamber extending along the longitudinal axis inside the cutting tool from said cutting portion, the chamber having dimensions enabling storing of the removed soft tissue portion inside the chamber thereby providing a validation to the channel creation.

IPC Classes  ?

23.

Apparatus for tissue removal

      
Application Number 17964299
Grant Number 12336935
Status In Force
Filing Date 2022-10-12
First Publication Date 2023-05-11
Grant Date 2025-06-24
Owner
  • SANOCULIS LTD (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Lavi, Gilad
  • Glovinsky, Yoseph
  • Shmukler, Vadim
  • Israeli, Nir

Abstract

An apparatus for use in tissue removal from a body organ is presented. The apparatus comprises a hand-held probe device, a rotating motor device and a connection assembly configured for removably interconnecting between the hand-held probe device and the rotating motor device. The hand-held probe device is disposable and comprises a housing having proximal and distal ends, a rotatable cutting tool extending distally from the distal end of the housing and being configured for cutting and removing tissue during rotation, and a transmission assembly passing inside the housing between the proximal and distal ends and being configured for transmitting rotational power to the rotatable cutting tool. The connection assembly is configured for engaging between the rotating motor device and the transmission assembly to thereby controllably rotate the cutting tool and remove tissue. In some embodiments, the apparatus includes a control unit for controlling operation of the apparatus, the control unit comprises an activation mechanism for activating the rotatable cutting tool, and a controller configured for operating the activation mechanism to generate a single fixed activation signal of a known intensity and duration during a predetermined time interval, thereby restricting operation of the cutting tool during the time interval to the single activation signal only.

IPC Classes  ?

  • A61F 9/007 - Methods or devices for eye surgery
  • A61B 17/00 - Surgical instruments, devices or methods
  • A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles

24.

DECOY TRANSCRIPTS FOR TREATMENT OF ssRNA VIRAL INFECTION

      
Application Number 17910293
Status Pending
Filing Date 2021-04-11
First Publication Date 2023-05-04
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Giat, Eitan
  • Giat, Yahel
  • Goldstein, Itamar

Abstract

There is provided a decoy transcript derived from a ssRNA virus (WV), the transcript comprising at least one of a 5′UTR of the WV, a genomic packaging signal (GPS) of the WV, a 3′UTR of the WV, and an exogenous stop codon.

IPC Classes  ?

  • A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
  • C12N 15/86 - Viral vectors
  • A61P 31/14 - Antivirals for RNA viruses

25.

Mammography apparatus

      
Application Number 18088569
Grant Number 11730436
Status In Force
Filing Date 2022-12-25
First Publication Date 2023-04-27
Grant Date 2023-08-22
Owner Tel HaShomer Medical Research, Infrastructure and Services Ltd. (Israel)
Inventor
  • Sklair-Levy, Miriam
  • Mayer, Arnaldo
  • Pfeffer, Shmuel Yitzhak

Abstract

A method of processing a given region of interest (ROI) of an X-ray image of a person's breast to determine presence of a malignancy, the X-ray image having X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image, the method comprising: for each given X-ray pixel in the given ROI and each of a selection of J(r) X-ray pixels at respective pixel radii PR(r), 1≤r≤R, from the given x-ray pixel, determining a binary number that provides a measure X-ray intensity indicated by the selected X-ray pixel relative to X-ray intensity indicated by the given X-ray pixel; using the determined binary numbers for the selected X-ray pixels at each pixel radius PR(r) to determine a decimal number for the pixel radius PR(r); histogramming the frequency of occurrence of values of the determined decimal numbers as a function of pixel radius for the given X-ray pixels in the given ROI; determining a texture feature vector, for the given ROI having components that are equal to the frequencies of occurrence for a selection of M histogrammed values; and processing the histogrammed frequencies of occurrence for the M values to determine whether the given ROI is malignant.

IPC Classes  ?

  • A61B 6/04 - Positioning of patientsTiltable beds or the like
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • G06T 7/00 - Image analysis
  • G06T 7/40 - Analysis of texture
  • G06T 7/11 - Region-based segmentation
  • G06T 7/13 - Edge detection
  • G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
  • G06V 10/42 - Global feature extraction by analysis of the whole pattern, e.g. using frequency domain transformations or autocorrelation
  • G06V 10/50 - Extraction of image or video features by performing operations within image blocksExtraction of image or video features by using histograms, e.g. histogram of oriented gradients [HoG]Extraction of image or video features by summing image-intensity valuesProjection analysis
  • G06T 7/44 - Analysis of texture based on statistical description of texture using image operators, e.g. filters, edge density metrics or local histograms
  • G06V 10/46 - Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]Salient regional features
  • A61B 6/12 - Arrangements for detecting or locating foreign bodies

26.

SECURE IDENTIFICATION OF AIR-GAPPED NETWORKS USING ONE-WAY COMMUNICATION

      
Application Number IL2022051089
Publication Number 2023/062637
Status In Force
Filing Date 2022-10-13
Publication Date 2023-04-20
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Friedman, Lavi
  • Shiloh, Edo
  • Shemesh, Shay
  • Inbar, Eyal

Abstract

Disclosed herein are receive-only network devices and methods for use for securely identifying a network. The receive-only network device comprised a network physical layer (PHY) circuit configured to establish a physical layer connection to a network via one or more wired transmission mediums and a controller electrically coupled to a receive channel of the PHY via a unidirectional hardware buffer configured to transfer electronic signals received from the PHY and block electronic signals received from the controller. The controller is configured to receive from the PHY one or more link layer frames transmitted by one or more network controllers of the network and intercepted by the PHY, extract one or more network attributes of the network from the one or more intercepted link layer frames, identify the network at least partially according to the one or more extracted network attributes, and present the identity of the network to a user.

IPC Classes  ?

  • H04L 9/40 - Network security protocols
  • H04L 45/02 - Topology update or discovery
  • G06F 21/30 - Authentication, i.e. establishing the identity or authorisation of security principals

27.

COMBINATIONS FOR RETAINING FOLLICLES RESERVE

      
Application Number IL2022051093
Publication Number 2023/062641
Status In Force
Filing Date 2022-10-16
Publication Date 2023-04-20
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor Meirow, Dror

Abstract

The present disclosure provides combinations inhibitors of phosphatidylinositol 3 -kinase (PI3K) pathway and agonists of anti-Mullerian hormone receptor type 2 (AMHR2), compositions and kits comprising the same, methods and uses thereof for retaining Primordial Follicle (PMF) reserve and increasing fertility.

IPC Classes  ?

  • A61K 38/22 - Hormones
  • A61K 38/24 - Follicle-stimulating hormone [FSH]Chorionic gonadotropins, e.g. HCGLuteinising hormone [LH]Thyroid-stimulating hormone [TSH]
  • A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
  • A61P 15/00 - Drugs for genital or sexual disordersContraceptives
  • A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

28.

MITOCHONDRIA-ENRICHED GENETICALLY ENGINEERED CELLS AND USES THEREOF

      
Application Number 17910304
Status Pending
Filing Date 2021-03-30
First Publication Date 2023-04-20
Owner
  • Minovia Therapeutics Ltd. (Israel)
  • Tel Hashomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Yivgi-Ohana, Natalie
  • Sher, Noa
  • Blumkin, Moriya
  • Jacoby, Elad

Abstract

The present invention is based on the discovery that cells enriched with mitochondria are useful for treating diseases and disorders. Disclosed are pharmaceutical compositions of mitochondrially-enriched genetically engineered T cells and methods of treatment using mitochondrially-enriched genetically engineered T cells.

IPC Classes  ?

  • A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
  • C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
  • C12N 15/86 - Viral vectors
  • A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
  • A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells

29.

DEVICE, SYSTEM AND METHOD FOR RESTORING TACTILE SENSATION USING A NANOGENERATOR

      
Application Number IL2022051009
Publication Number 2023/053110
Status In Force
Filing Date 2022-09-21
Publication Date 2023-04-06
Owner
  • RAMOT AT TEL AVIV UNIVERSITY LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Maoz, Ben Meir
  • Markovich, Gil
  • Arami, Amir
  • Shlomy, Iftach

Abstract

Provided herein are devices, systems and methods for restoring tactile sensation in a subject, using a subcutaneously implanted nanogenerator which is connected to at least one of the subject's sensory nerves and is configured to produce an electric signal upon external stimulus and provide the electric signal to the sensory nerve to thereby stimulate the nerve in accordance with the external stimulus.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators
  • H02N 1/04 - Friction generators

30.

SYSTEM AND METHOD FOR MONITORING TREATMENT THROUGH PET-CT COMBINATION IMAGING

      
Application Number IL2022050883
Publication Number 2023/021504
Status In Force
Filing Date 2022-08-15
Publication Date 2023-02-23
Owner
  • TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • A.Y.Y.T. - TECHNOLOGICAL APPLICATIONS AND DATA UPDATE LTD. (Israel)
Inventor
  • Davidson, Tima
  • Nissan, Johnatan
  • Melamed, Amit
  • Gindi, Moriel
  • Malka, Dror

Abstract

A system and method are presented for monitoring treatment of a patient. The system comprises data input and output utilities, memory, and a data processor, and is configured for data communication with an image data provider to receive therefrom image data indicative of combined PET-CT scan images including at least one first pre-treatment full body scan image of a patient and at least one second post-treatment full body scan image of said patient. The data processor comprises: an identifier utility configured to process the image data to identify matching first and second 2D regions in, respectively, first 2D slices forming the first pre- treatment full body scan image and second 2D slices forming the second post-treatment full body scan image, and locate at least one pair of corresponding first and second 3D regions in the first and second full body scan images, respectively; and an analyzer configured and operable to analyze each of said at least one pair of the first and second 3D regions and determine a change in at least one parameter of interest in the first and second 3D regions, and generate output data indicative of said change.

IPC Classes  ?

  • A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves

31.

COMPOSITION COMPRISING AN RNA THERAPEUTIC TARGETING FAT10 AND USES OF SAME FOR TREATING DISORDERS CHARACTERIZED BY ABNORMAL LIPID ACCUMULATION

      
Application Number IL2022050894
Publication Number 2023/021512
Status In Force
Filing Date 2022-08-17
Publication Date 2023-02-23
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Kamari, Yehuda
  • Kandel-Kfir, Michal
  • Harats, Dror
  • Dominissini, Dan
  • Rechavi, Gideon
  • Shaish, Aviv

Abstract

This disclosure is directed to compositions comprising an RNA therapeutic targeting FAT10 and uses of same.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
  • A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
  • A61P 3/06 - Antihyperlipidemics

32.

PROCESS FOR KIDNEY CELL MANUFACTURE AND TREATMENT

      
Application Number 17795270
Status Pending
Filing Date 2021-01-25
First Publication Date 2023-02-16
Owner
  • KIDNEYCURE LTD (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD (Israel)
Inventor
  • Simanovsky, Masha
  • Dekel, Benjamin

Abstract

Embodiments described herein relate to a method for preparing cultured cells, the method comprising: obtaining kidney tissue from a human subject; mechanically dissociating the tissue; subjecting the tissue to enzymatic digestion; incubating the tissue with media in a cell culture plate to form cultured cells.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • A61K 35/22 - UrineUrinary tract, e.g. kidney or bladderIntraglomerular mesangial cellsRenal mesenchymal cellsAdrenal gland
  • A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
  • A61K 9/00 - Medicinal preparations characterised by special physical form

33.

SYSTEM, DEVICE AND METHOD FOR DETERMINING AND/OR ASSESSING BRAIN RELATED CONDITIONS BASED ON PUPIL LIGHT RESPONSE

      
Application Number 17885812
Status Pending
Filing Date 2022-08-11
First Publication Date 2023-02-16
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Rotenstreich, Ygal
  • Sher, Ifat

Abstract

Provided herein are systems, devices and methods for monitoring the progression of, determining and/or assessing brain related conditions in a subject based on pupil light responses (PLRs) to focal central and peripheral chromatic light stimuli, in particular, by classifying the PLR based on one or more PLR parameter values, wherein the classifying allows monitoring the progression of, determining and/or assessing the brain related condition

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
  • A61B 3/11 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring interpupillary distance or diameter of pupils

34.

PATIENT REPOSITIONING APPARATUS AND METHOD

      
Application Number IB2022057414
Publication Number 2023/017414
Status In Force
Filing Date 2022-08-09
Publication Date 2023-02-16
Owner
  • TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • SAVION INDUSTRIES LTD. (Israel)
Inventor
  • Klein, Yoram
  • Zimbalista, Ran

Abstract

Apparatus (200) for turning a patient in a bed (100), is provided. The apparatus (200) includes a frame (280) that includes longitudinal poles (210) placed above the bed (100), and patient-rotating straps (220) extending from the longitudinal poles (210) toward the bed (100) configured to securely hold the patient, and to be movable to rotate the patient with respect to the bed from an initial position to a second position. The apparatus further includes a motor (260) that is operable to change a height of patient-rotating straps (220) on one side of the patient relative to a height of patient-rotating straps (220) on the second side of the patient, such as to cause the patient to turn between the supine and prone positions. Other applications are also described.

IPC Classes  ?

  • A61G 7/10 - Devices for lifting patients or disabled persons, e.g. special adaptations of hoists thereto

35.

PELARGONIUM GRAVEOLENS EXTRACT FOR THE TREATMENT OF TRAUMATIC BRAIN INJURIES

      
Application Number IL2022050836
Publication Number 2023/012795
Status In Force
Filing Date 2022-08-02
Publication Date 2023-02-09
Owner
  • THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Liraz Zaltsman, Sigal
  • Elmann, Anat
  • Dudai, Nativ

Abstract

The present invention provides methods and compositions comprising essential oil extracted from Pelargonium graveolens for treating, preventing, or ameliorating traumatic brain injury (TBI) in a subject, or for improving cognitive functions in a subject suffering from TBI.

IPC Classes  ?

  • A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

36.

DIAGNOSING INFLAMMATORY BOWEL DISEASES

      
Application Number IL2022050793
Publication Number 2023/002491
Status In Force
Filing Date 2022-07-21
Publication Date 2023-01-26
Owner
  • YEDA RESEARCH AND DEVELOPMENT CO. LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Itzkovitz, Shalev Shaul
  • Bahar Halpern, Keren
  • Egozi, Adi
  • Ben-Horin, Shomron Silan
  • Ungar, Bella
  • Ben-Moshe, Shani

Abstract

A method of diagnosing an inflammatory bowel disease (IBD) of a subject is disclosed. The method comprises analyzing the RNA expression level of particular human gene in a fecal RNA sample of the subject, wherein when the expression level is above a predetermined amount it is indicative of the inflammatory bowel disease.

IPC Classes  ?

  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

37.

DIAGNOSIS AND TREATMENT OF PANCREATIC CANCER

      
Application Number IL2022050700
Publication Number 2023/275872
Status In Force
Filing Date 2022-06-29
Publication Date 2023-01-05
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Yablecovitch, Doron
  • Laish, Ido

Abstract

A method of diagnosing pancreatic cancer in a subject in need thereof is provided. The method comprising determining a level of at least syndecan 1 (SDC1) in a blood sample or a fraction thereof of the subject, wherein when the level of SDC1 is above a predetermined threshold, the subject is diagnosed with pancreatic cancer.

IPC Classes  ?

  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61P 35/00 - Antineoplastic agents
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
  • G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
  • G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
  • C12Q 1/6813 - Hybridisation assays

38.

Ventricular structure reshaping atrio-ventricular valve

      
Application Number 17932014
Grant Number 12097114
Status In Force
Filing Date 2022-09-14
First Publication Date 2023-01-05
Grant Date 2024-09-24
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Raanani, Ehud
  • Orlov, Boris
  • Harari, Boaz
  • Meiri, Oded
  • Rozitsky, Lichen

Abstract

Apparatus and methods are described including placing a valve frame within a subject's heart. The valve frame includes a valve frame body that is configured to support the prosthetic valve within the native atrio-ventricular valve, and at least one arm that is configured to extend from a ventricular portion of the valve frame. The at least one arm is deployed among chords of the native atrio-ventricular valve. Subsequently, at least a portion of the valve frame is rotated in a direction in which an interior of the arm faces, such as to modify shapes of the native valve leaflets and the ventricular structures, by recruiting and deflecting at least a portion of the chords. The frame body of the valve frame is then radially expanded, such as to hold the native valve leaflets and the ventricular structures at least partially in the modified shapes. Other applications are also described.

IPC Classes  ?

39.

METHOD AND SYSTEM FOR DETERMINING CONDITION OF A SUBJECT BASED ON CONNECTOME

      
Application Number IL2022050671
Publication Number 2022/269613
Status In Force
Filing Date 2022-06-22
Publication Date 2022-12-29
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Livny-Ezer, Abigail
  • Meningher, Inbar
  • Berlinerblau, Gregory
  • Raizman, Reut Moran

Abstract

A method of determining a condition of a subject comprises receiving functional magnetic resonance (MR) data and structural MR data, each describing the brain of the subject. A subject-specific functional connectome (FC) is constructed using the functional MR data, and a subject-specific structural connectome (SC) is constructed using the structural MR data. A convolutional neural network (CNN) is fed with the subject-specific FC and SC. The CNN has a first set of layers that separately process the subject-specific FC and SC, and a second set of layers that process combined outputs from the first set of layers. An output indicative of the condition of the subject is received from the second set of layers of the CNN.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

40.

PERITONEAL SEPARATION APPARATUS

      
Application Number IL2022050674
Publication Number 2022/269614
Status In Force
Filing Date 2022-06-22
Publication Date 2022-12-29
Owner TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Hazzan, David
  • Lavi, Gilad

Abstract

The present disclosure relates to an apparatus for mechanically displacing tissue during laparoscopic procedures (e.g., hernia procedures). More specifically, the disclosure relates to an apparatus introduced into the space between the peritoneum and the muscle tissue; and, once in place, actively operated to separate thereof and generate working space therewithin.

IPC Classes  ?

  • A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors

41.

VALVE FRAME FOR PROSTHETIC TRICUSPID VALVE

      
Application Number IB2022055593
Publication Number 2022/264082
Status In Force
Filing Date 2022-06-16
Publication Date 2022-12-22
Owner TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Orlov, Boris
  • Raanani, Ehud

Abstract

Apparatus and methods are described for use with a native tricuspid valve of a heart of a mammalian subject. A valve frame (22) includes a valve-frame body (32) that is configured to support prosthetic valve leaflets (20) within the native tricuspid valve. Chord-recruiting arms (30) are configured to extend from the valve-frame body at circumferential regions corresponding to the anterior leaflet and the posterior leaflet of the native tricuspid valve. An anchoring arm (28) is configured to extend from the valve-frame body at a circumferential region corresponding to the septal leaflet of the native tricuspid valve, the anchoring arm (28) being longer than each of the chord-recruiting arms (30). Other applications are also described.

IPC Classes  ?

42.

SYSTEM AND METHOD FOR ANALYZING ABDOMINAL SCAN

      
Application Number IL2022050518
Publication Number 2022/244002
Status In Force
Filing Date 2022-05-18
Publication Date 2022-11-24
Owner
  • RAMOT AT TEL-AVIV UNIVERSITY LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Mayer, Arnaldo
  • Manor, Tamir
  • Halle, Asaf
  • Kiryati, Nahum
  • Konen, Eliahu
  • Pickovsky, Jana

Abstract

A method of analyzing an abdominal computed tomography (CT) scan comprises applying a colon segmentation machine learning procedure to the CT scan, and receiving from the colon segmentation machine learning procedure an output indicative of a plurality of colon segments. The method also comprises feeding the output into a colon lesion detection machine learning procedure, and receiving from the colon lesion detection machine learning procedure an output indicative of presence of at least one pathology in the colon.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 6/03 - Computed tomography [CT]
  • G06N 20/00 - Machine learning
  • G06N 3/00 - Computing arrangements based on biological models

43.

DISEASE CLASSIFIER AND DYSBIOSIS INDEX TOOLS

      
Application Number IL2022050521
Publication Number 2022/244005
Status In Force
Filing Date 2022-05-19
Publication Date 2022-11-24
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Haberman Ziv, Yael
  • Abbas, Haya
  • Braun, Tzipi
  • Amir, Amnon

Abstract

Herein disclosed are a computer-implemented method, a system, and a kit for assessing/classifying the health status associated with a microbiome profile of a gastrointestinal (GI) sample. The method includes receiving data regarding expression levels of amplicon sequence variants (ASVs) of a V4 region of 16S rRNA in a GI sample of a subject, and utilizing a machine learning algorithm that is trained to distinguish a healthy state from a sick state, a score is computed, and a prediction is made for the presence of a general microbial response that is shared by a large variety of diseases.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 10/00 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
  • G06N 5/00 - Computing arrangements using knowledge-based models
  • G06N 20/00 - Machine learning
  • G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
  • G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G16C 20/70 - Machine learning, data mining or chemometrics
  • G16B 30/10 - Sequence alignmentHomology search

44.

Chorda replacement apparatus and method

      
Application Number 17624437
Grant Number 12310852
Status In Force
Filing Date 2020-07-03
First Publication Date 2022-11-17
Grant Date 2025-05-27
Owner TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Serraf, Alain Elie
  • Tejman-Yarden, Mila Shai Raziel
  • Shafrir, Roey

Abstract

Apparatus for coupling a prosthetic chorda to an atrioventricular valve leaflet, the apparatus comprising: a neochorda delivery system comprising a steerable and pushable catheter housing a neochorda attached to a neochorda puncture needle, the catheter operable to push the puncture needle to puncture and thread the neochorda through a papillary muscle of a ventricle; a retriever system comprising a catheter housing a grabber operable to capture the neochorda puncture needle after being threaded through the papillary muscle and withdraw the neochorda puncture needle and neochorda from the ventricle; and a tissue clamping system comprising a catheter housing distal and proximal tissue clamps deployable to clamp a region of an atrioventricular valve between them and hold the region so that it may be punctured by the puncture needle to deliver the neochorda through the leaflet and to the papillary muscle.

IPC Classes  ?

  • A61F 2/24 - Heart valves
  • A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials

45.

SYSTEMS AND METHODS FOR RECONSTRUCTION OF 3D IMAGES FROM ULTRASOUND AND CAMERA IMAGES

      
Application Number IL2022050387
Publication Number 2022/219631
Status In Force
Filing Date 2022-04-13
Publication Date 2022-10-20
Owner
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • SAMI SHAMOON COLLEGE OF ENGINEERING (R.A) (Israel)
Inventor
  • Speter, Chen
  • Manzur, Doron
  • Giladi, Chen

Abstract

There is provided a method for reconstructing a 3D image, comprising: obtaining Doppler ultrasound images depicting a blood vessel and measurement of blood flow in the blood vessel, and 2D camera images captured by a camera depicting fiducial objects randomly distributed within a viscous material and spaced apart by random distances on a surface of the individual, computing 3D coordinates within a world coordinate system for pixels of the Doppler images using an external reference of an ultrasound transducer pose computed by analysis of relative changes in locations of the fiducial objects within sequential camera images, and computing a respective estimated blood flow for pixels of the Doppler images at locations within the blood vessel, reconstructing a 3D image from 3D voxels computed from the 3D coordinates of pixels of the Doppler images, including respective estimated blood flow, wherein the 3D image depicts the blood vessel and blood flow.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
  • A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
  • A61B 8/06 - Measuring blood flow
  • A61B 8/08 - Clinical applications
  • A61B 8/14 - Echo-tomography
  • A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

46.

METHOD AND SYSTEM FOR PROCESSING COMPUTERIZED TOMOGRAPHY IMAGES

      
Application Number IL2022050361
Publication Number 2022/215074
Status In Force
Filing Date 2022-04-06
Publication Date 2022-10-13
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Mardor, Yael
  • Last, David
  • Daniels Elmakias, Dianne
  • Sharabi, Shirley
  • Bar, Jair
  • Forie, Nadav
  • Levy, Liran
  • Marom, Edith Michelle

Abstract

A method of analyzing CT data comprises receiving data describing a pre-contrast administration CT scan from a body region of the subject, and a post-contrast administration CT scan acquired from the body region at least 1 minute after initiation of administration of a contrast agent to the subject. A subtraction map is formed by subtracting one of the scans from another. The subtraction map is displayed in a manner that identifies leaking of contrast agent out of blood vessels in the region.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/03 - Computed tomography [CT]
  • A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow

47.

Device and method for creating a channel in soft tissue

      
Application Number 17828749
Grant Number 11583442
Status In Force
Filing Date 2022-05-31
First Publication Date 2022-09-22
Grant Date 2023-02-21
Owner
  • SANOCULIS LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND S (Israel)
Inventor
  • Lavi, Gilad
  • Glovinsky, Yoseph
  • Shmukler, Vadim
  • Israeli, Nir

Abstract

Medical devices and methods for removing a predetermined portion of soft tissue from a target tissue layer, thereby creating a channel between two side walls of the target tissue layer, are described. The medical device is a cutting tool comprising: an elongated round body extending along a longitudinal axis and having a uniform outer cross-section at a proximal side thereof; a cutting portion at a distal side of the elongated body, comprising at a distal end thereof a cutting edge of a first cross-section being smaller than said outer cross-section, and a distally and continuously decreasing outer cross-section; and a chamber extending along the longitudinal axis inside the cutting tool from said cutting portion, the chamber having dimensions enabling storing of the removed soft tissue portion inside the chamber thereby providing a validation to the channel creation.

IPC Classes  ?

48.

METHODS AND KITS FOR IDENTIFYING THROMBUS ORIGIN AND OPTIMIZING POST-ISCHEMIC EVENT TREATMENT

      
Application Number 17631162
Status Pending
Filing Date 2020-07-23
First Publication Date 2022-09-22
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Orion, David
  • Itsekson-Hayosh, Zeev
  • Shavit-Stein, Efrat
  • Chapman, Joab

Abstract

Provided herein are method and kits for identifying thrombus origin based on temporal thrombin activity assay, and use thereof for optimizing post-ischemic event treatment, and further preventing recurrence of secondary ischemic events.

IPC Classes  ?

  • C12Q 1/56 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen

49.

XR-BASED PLATFORM FOR NEURO-COGNITIVE-MOTOR-AFFECTIVE ASSESSMENTS

      
Application Number IB2022052172
Publication Number 2022/190039
Status In Force
Filing Date 2022-03-10
Publication Date 2022-09-15
Owner TEL-HASHOMER - MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Plotnik-Peleg, Meir
  • Hagur-Bahat, Yotam
  • Ben-Gal, Oran
  • Kribus-Shmiel, Lotem
  • Arad, Evyatar
  • Wilf, Meytal
  • Galor, Noam

Abstract

A method of implementing an extended reality (XR) neuropsychological test of a person, including projecting onto an immersive display configured to display to the person three-dimensionally a series of virtual objects and conducting a cognitive test measuring executive functions using the virtual objects; simultaneously commanding sensors to monitor motor skills including at least one of: (i) gross hand movement by commanding a motion sensor, (ii) head movement by commanding a motion sensor, (iii) an eye movement of the person by commanding eye tracking, (iv) a gait by commanding at least one of mobility sensors, motion capture system sensors, force plate sensors or insole sensors and (v) postural stability by commanding at least one of mobility sensors, force plate sensors and insole sensors, and integrating the signals from the sensors so as to determine a neurocognitive and/or motor level of the person and produce output. Affect may also be measured.

IPC Classes  ?

  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

50.

MACHINE LEARNING MODELS FOR PREDICTION OF UNPLANNED CESAREAN DELIVERY

      
Application Number IL2022050244
Publication Number 2022/185320
Status In Force
Filing Date 2022-03-03
Publication Date 2022-09-09
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Tsur, Abraham
  • Meyer, Raanan
  • Eilenberg, Roni

Abstract

There is provided a computer implemented method of training a machine learning model for prediction of unplanned Cesarean Delivery (uCD), comprising: creating or receiving a multirecord training dataset, wherein a record comprises: at least one fetal biometric parameter of a sample fetus obtained by an ultrasonography device, at least one personal parameter of a sample mother of the sample fetus, and a ground truth indicating whether a birth of the sample fetus by the sample mother was a uCD, and training the machine learning model on the multi-record training dataset for generating an outcome indicating likelihood of uCD for a target mother in response to an input of at least one fetal biometric parameter of a target fetus of the target mother and at least one personal parameter of the target mother.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body
  • A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves

51.

METHOD AND SYSTEM FOR IMAGING EYE BLOOD VESSELS

      
Application Number IL2022050073
Publication Number 2022/153320
Status In Force
Filing Date 2022-01-18
Publication Date 2022-07-21
Owner
  • RAMOT AT TEL-AVIV UNIVERSITY LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Rotenstreich, Ygal
  • Sher Rosenthal, Ifat
  • Suchowski, Haim
  • Mrejen, Michael
  • Katz, Shahar

Abstract

A method of diagnosing a condition of a subject, comprises: receiving image data of an anterior of an eye of the subject, and analyzing the image data to detect at least one of: flow of individual blood cells in libmal or conjunctival blood vessels of the eye, morphology of limbal or conjunctival blood vessels. The method also comprises determining the condition of the subject based on the detection(s).

IPC Classes  ?

  • A61B 3/14 - Arrangements specially adapted for eye photography
  • A61B 5/026 - Measuring blood flow
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
  • A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes

52.

AURICULAR RECONSTRUCTION USING 3D PRINTED AUTOLOGOUS CARTILAGE TISSUE

      
Application Number IL2022050016
Publication Number 2022/144905
Status In Force
Filing Date 2022-01-04
Publication Date 2022-07-07
Owner
  • TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Levenberg, Shulamit
  • Landau, Shira
  • Duvdevani, Shay

Abstract

An aspect of some embodiments of the invention relates to methods of manufacturing a 3D printed implant, comprising printing a mold of a scaffold, generating said scaffold from said mold, seeding cells on said scaffold, where said generating said scaffold comprises generating parts of said scaffold with different levels of stiffness.

IPC Classes  ?

  • A61F 2/18 - Internal ear or nose parts, e.g. ear-drums
  • A61F 11/20 - Ear surgery
  • A61L 27/58 - Materials at least partially resorbable by the body
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells

53.

EMBOLIC PROTECTION DEVICE

      
Application Number 17604037
Status Pending
Filing Date 2020-04-16
First Publication Date 2022-06-30
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Nozyk, Ram
  • Halak, Moshe

Abstract

Apparatus and methods are described for capturing emboli during a medical procedure that is performed at a first location within a subjects body. An intravascular device (24) is configured to perform the medical procedure at the first location. An inner sheath (32) facilitates insertion of the intravascular device (24) into the subjects body, by the intravascular device being inserted via a lumen (31) of the inner sheath (32). A filter (34) extending from a distal-most portion (42) of the inner sheath (32) has a non-radially-constrained configuration in which the filter (34) is configured to prevent at least some emboli that are generated by the medical procedure from passing through the filter (34). Other applications are also described.

IPC Classes  ?

  • A61F 2/01 - Filters implantable into blood vessels
  • A61M 29/00 - Dilators with or without means for introducing media, e.g. remedies

54.

COMPOUNDS FOR TREATING EYE DISEASES AND DISORDERS

      
Application Number IL2021051470
Publication Number 2022/123573
Status In Force
Filing Date 2021-12-09
Publication Date 2022-06-16
Owner
  • THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) (Israel)
  • TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Elmann, Anat
  • Rotenstreich, Ygal
  • Sher, Ifat

Abstract

The invention concerns 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone (TTF) or a pharmaceutically acceptable salt or solvate thereof for use in treating, preventing, or ameliorating an eye disease or disorder, or for providing adjunct treatment to an ocular therapeutic procedure. The invention also concerns ophthalmic compositions comprising TTF.

IPC Classes  ?

  • A61K 36/28 - Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
  • A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 27/02 - Ophthalmic agents

55.

COMPOUNDS FOR TREATING EYE DISEASES AND DISORDERS

      
Document Number 03201534
Status Pending
Filing Date 2021-12-09
Open to Public Date 2022-06-16
Owner
  • TEL HASHOMER-MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT AGRICULTURAL RESEARCH ORGANIZATION (ARO) (Israel)
Inventor
  • Elmann, Anat
  • Rotenstreich, Ygal
  • Sher, Ifat

Abstract

The invention concerns 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone (TTF) or a pharmaceutically acceptable salt or solvate thereof for use in treating, preventing, or ameliorating an eye disease or disorder, or for providing adjunct treatment to an ocular therapeutic procedure. The invention also concerns ophthalmic compositions comprising TTF.

IPC Classes  ?

  • A61K 36/28 - Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
  • A61P 27/02 - Ophthalmic agents

56.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF UROTHELIAL CANCER

      
Application Number IL2021051462
Publication Number 2022/123566
Status In Force
Filing Date 2021-12-08
Publication Date 2022-06-16
Owner
  • THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI INSTITUTE) (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Koltai, Hinanit
  • Anis, Omer

Abstract

Compositions capable of reducing viability, initiating apoptosis, inducing cell cycle arrest and/or reducing migration of urothelial carcinoma cells and methods of use thereof are provided. The compositions and uses thereof comprise cannabinoids.

IPC Classes  ?

  • A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
  • A61P 35/00 - Antineoplastic agents
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines

57.

DUNALIELLA ALGA PREPARATION FOR PREVENTION AND/OR TREATMENT OF A NEURODEGENERATIVE DISEASE, A DISORDER ASSOCIATED WITH PROTEIN MISFOLDING AND COGNITIVE DECLINE

      
Application Number 17594084
Status Pending
Filing Date 2020-04-01
First Publication Date 2022-06-09
Owner
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • NIKKEN SOHONSHA CORPORATION (Japan)
Inventor
  • Shaish, Aviv
  • Harats, Dror
  • Beeri, Michal
  • Lubitz, Irit

Abstract

The present invention provides neuroprotective preparations, specifically, Dunaliella alga preparations and uses thereof in the treatment and prophylaxis of neurodegenerative disorders, protein misfolding and cognitive decline.

IPC Classes  ?

  • A61K 36/05 - Chlorophycota or chlorophyta (green algae), e.g. Chlorella
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

58.

Synthetic somatostatin receptor ligands

      
Application Number 17591620
Grant Number 11827687
Status In Force
Filing Date 2022-02-03
First Publication Date 2022-05-26
Grant Date 2023-11-28
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Kostenich, Genady
  • Oron-Herman, Mor
  • Orenstein, Arie
  • Shekhter Zahavi, Talia
  • Gazit, Ehud
  • Salitra, Yoseph
  • Buzhansky, Ludmilla

Abstract

Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.

IPC Classes  ?

  • C07K 14/655 - Somatostatins
  • A61K 38/08 - Peptides having 5 to 11 amino acids
  • A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
  • A61K 38/12 - Cyclic peptides
  • A61K 49/00 - Preparations for testing in vivo

59.

TREATMENT OF RETINAL DISORDERS

      
Application Number IL2021051330
Publication Number 2022/097156
Status In Force
Filing Date 2021-11-09
Publication Date 2022-05-12
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Chapman, Joab
  • Shavit Stein, Efrat
  • Rotenstreich, Ygal
  • Sher Rosenthal, Ifat

Abstract

Ophthalmic formulations comprising a PARI antagonist and/or an agent that interferes with an interaction of PARI and a protease (e.g., thrombin), and an ophthalmically acceptable carrier, and uses thereof in treating or preventing retinal pathologies such as retinal degeneration, are provided. The agent can be, for example, a peptide conjugate represented by Formula I, as defined in the specification.

IPC Classes  ?

  • A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
  • A61K 38/57 - Protease inhibitors from animalsProtease inhibitors from humans
  • A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
  • A61P 27/02 - Ophthalmic agents

60.

Device and method for spectral imaging

      
Application Number 17582741
Grant Number 12287240
Status In Force
Filing Date 2022-01-24
First Publication Date 2022-05-12
Grant Date 2025-04-29
Owner
  • Bar-Han University (Israel)
  • Tel HaShomes Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Garini, Yuval
  • Bronshtein-Berger, Irena
  • Barshack, Iris

Abstract

A spectral imaging device includes an imager, a scanning stage to establish relative motion between the imager and a sample in a scanning direction and an optical system controlling a light characteristic of a light beam constituting an image of the sample to the imager. The optical system includes a light varying element to receive the light beam and provide an output light beam with spatially varying light characteristic over a cross-section thereof. A set of redirecting optical elements direct light rays from the sample to form the light beam, and to focus the output light beam onto the imager. A controller controls the scanning stage and the imager to capture a plurality of image frames with an overlap including a defined shift that is greater than 1 pixel along the scanning direction between consecutive image frames. A computing device consolidates image data to provide an image of the sample.

IPC Classes  ?

  • G01J 3/28 - Investigating the spectrum
  • G01J 3/46 - Measurement of colourColour measuring devices, e.g. colorimeters
  • G01J 3/06 - Scanning arrangements

61.

DIAGNOSIS AND TREATMENT OF MEDULLOBLASTOMA

      
Application Number 17430072
Status Pending
Filing Date 2020-02-27
First Publication Date 2022-05-05
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD (Israel)
Inventor
  • Shai, Ruty
  • Freedman Picciotto, Shany
  • Toren, Amos

Abstract

Methods for classifying, identifying and monitoring of a medulloblastoma tumor in a subject are provided, based on lincRNA expression in the tumor and/or in a biological sample of the subject. Compositions and methods for treating medulloblastoma using inhibitors of the specific lincRNAs disclosed herein. Additionally, novel inhibitory nucleic acids targeting the specific lincRNAs are provided.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6851 - Quantitative amplification
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
  • A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
  • A61P 35/00 - Antineoplastic agents

62.

TRANSCATHETERAL DEPLOYMENT OF A MEDICAL DEVICE WITHOUT USE OF A NOSE CONE

      
Application Number IB2021059798
Publication Number 2022/090881
Status In Force
Filing Date 2021-10-24
Publication Date 2022-05-05
Owner TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor Orlov, Boris

Abstract

Apparatus and methods are described including a medical device (22, 90), and a delivery catheter (24) that is configured deliver the medical device (22, 90) to a portion of subject's body. An overtube (40) is configured to maintain a proximal portion of the medical device (22, 90) in a radially-constrained configuration, during delivery of the medical device (22, 90) to the portion of the subject's body. A string-rod constraining mechanism (41) includes a rod (44) disposed at least partially within the overtube (40), and at least one string (42). The string-rod mechanism (41) maintains a distal portion of the medical device (22, 90) in a radially-constrained configuration, when the overtube (40) is not covering the distal portion of the medical device (22, 90), by the at least one string (42) extending from the distal portion of the medical device to the rod (44). Other applications are also described.

IPC Classes  ?

  • A61F 2/24 - Heart valves
  • A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
  • A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

63.

ATRIOVENTRICULAR VALVE FRAME WITH OPPOSING SETS OF ARMS

      
Application Number IB2021059799
Publication Number 2022/090882
Status In Force
Filing Date 2021-10-24
Publication Date 2022-05-05
Owner TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor Orlov, Boris

Abstract

Apparatus and methods are described for use with a prosthetic valve (20) that is configured to be deployed within a native atrioventricular valve of a heart of a mammalian subject. A valve frame (22) includes a valve-frame body (24) that is configured to support the prosthetic valve (20) within the native atrioventricular valve. A first set of chord-recruiting arms (34) are configured to extend from the valve-frame body (24) and to curve around the valve-frame body (24) circumferentially in a first circumferential direction. A second set of chord-recruiting arms (34) are configured to extend from the valve-frame body (24) and to curve around the valve-frame body (24) circumferentially in a second circumferential direction that is an opposite direction from the first circumferential direction. Other applications are also described.

IPC Classes  ?

64.

URINE-DERIVED EPITHELIAL CELL CULTURES, NEPHROSPHEROIDS DERIVED THEREFROM AND METHODS OF PRODUCING AND USING SAME

      
Application Number IL2021051242
Publication Number 2022/084998
Status In Force
Filing Date 2021-10-19
Publication Date 2022-04-28
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Dekel, Benjamin
  • Omer, Dorit
  • Harari-Steinberg, Orit

Abstract

A nephrospheroid comprising urine-derived epithelial cells, the nephrospheroid is capable of forming a tubular nephric tissue upon transplantation. Also provided are methods of producing the nephrospheroid and using same.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • A61K 35/22 - UrineUrinary tract, e.g. kidney or bladderIntraglomerular mesangial cellsRenal mesenchymal cellsAdrenal gland
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

65.

MARKER FOR RESPONSE TO PD-1/PD-L1 IMMUNOTHERAPY

      
Application Number IL2021051196
Publication Number 2022/074648
Status In Force
Filing Date 2021-10-05
Publication Date 2022-04-14
Owner
  • 4C BIOMED LIMITED (United Kingdom)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Greenberg, Eyal
  • Galore-Haskel, Gilli
  • Merhavi-Shoham, Efrat
  • Markel, Gal

Abstract

Methods of determining suitability of a subject to be treated with a PD-1/PD-L1 based immunotherapy, comprising receiving a sample from the subject and determining HVEM levels in the sample, wherein expression of HVEM above a predetermined threshold indicates the subject is suitable to be treated by the immunotherapy or of determining suitability of a subject non-responsive to a PD-1/PD-L1 based immunotherapy to be treated by an HVEM based immunotherapy, comprising receiving a sample from the subject and determining T cell levels in the sample, wherein T cell levels above a predetermined threshold indicates the subject is suitable to be treated by the HVEM based immunotherapy are provided.

IPC Classes  ?

  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

66.

METHOD OF DIAGNOSING BREAST CANCER

      
Application Number IL2021051182
Publication Number 2022/070194
Status In Force
Filing Date 2021-09-30
Publication Date 2022-04-07
Owner
  • YEDA RESEARCH AND DEVELOPMENT CO. LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Lev, Sima
  • Vinik, Yaron
  • Ortega, Francisco Gabriel
  • Gutman Md, Mordechai

Abstract

A method of diagnosing breast cancer is disclosed. The method comprises lysing extracellular vesicles of a subject to generate a composition comprising components of extracellular vesicles; measuring the amount of MEK1 in the composition; and diagnosing the subject with breast cancer when a level of said MEK1 in said composition is above a predetermined threshold. Kits for breast cancer diagnosis are also disclosed.

IPC Classes  ?

  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

67.

Delftia

      
Application Number 17548662
Grant Number 12251417
Status In Force
Filing Date 2021-12-13
First Publication Date 2022-03-31
Grant Date 2025-03-18
Owner
  • Ministry of Health, State of Israel (Israel)
  • Sami Shamoon College of Engineering (R.A) (Israel)
  • Tel HaShomer Medical Research lnfrastructure and Services Ltd. (Israel)
Inventor
  • Nissan, Israel
  • Tejman-Yarden, Noa Lea
  • Rubinovitz, Chaim
  • Davidov, Yakov
  • Rahav, Galia
  • Robinson, Ari
  • Shotland, Yoram

Abstract

Delftia bacteria are disclosed. Antimicrobial agents derived therefrom are also disclosed.

IPC Classes  ?

  • A61K 38/08 - Peptides having 5 to 11 amino acids
  • A61K 33/242 - GoldCompounds thereof
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61P 31/04 - Antibacterial agents
  • C12N 1/20 - BacteriaCulture media therefor
  • C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

68.

A FACE SHIELD CONDENSATION REDUCTION DEVICE AND METHOD

      
Application Number IL2021051071
Publication Number 2022/054042
Status In Force
Filing Date 2021-09-01
Publication Date 2022-03-17
Owner TEL-HASHOMER - MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Shafferman, Eran
  • Sadan, Yair
  • Arbel, Elder
  • Davidov, Valery
  • Keizman, Dor

Abstract

A face shield system that comprises a condensation reduction device configured to provide a user with a face shield not susceptible to vapor condensation accumulating upon the face shield visor which may cause a significant visibility reduction and potential health hazards.

IPC Classes  ?

  • A42B 3/24 - Visors with means for avoiding fogging or misting
  • A41D 13/11 - Protective face masks, e.g. for surgical use, or for use in foul atmospheres
  • A61B 90/50 - Supports for surgical instruments, e.g. articulated arms

69.

SIMULTANEOUS ECMO AND CRRT

      
Application Number 17416508
Status Pending
Filing Date 2019-12-26
First Publication Date 2022-03-17
Owner TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor Kogan, Alexander

Abstract

A controller for controlling an apparatus comprising a blood pump, oxygenator, and blood filtering system connected together by blood flow tubing and to a patient to circulate blood from the patient through the apparatus and back to the patient, to oxygenate and filter the blood, the controller comprising at least one communication interface operable to receive signals generated responsive to monitored parameters characterizing blood flow and/or quality of blood from the patient circulating through the apparatus and configured to: determine values for the monitored parameters based on the monitoring signals; determine whether or not a value determined for a given monitored parameter for blood circulating through the apparatus is within a normative range for the parameter; and generate an alarm to alert an operator of the system if the value is not within the normative range.

IPC Classes  ?

  • A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
  • A61M 1/14 - Dialysis systemsArtificial kidneysBlood oxygenators
  • A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration

70.

INJECTION DEVICE WITH BOTH LINEAR AND ROTARY INDEPENDENT MOTOR DRIVES

      
Application Number IB2021057566
Publication Number 2022/038516
Status In Force
Filing Date 2021-08-17
Publication Date 2022-02-24
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor Rotenstreich, Ygal

Abstract

Embodiments pertain to an apparatus for injecting a medicament into a tissue, the apparatus comprising: a rotary motion drive having a motion drive rotary axis and which is configured to receive a needle and operable to rotate the needle about the motion drive rotary axis; and a linear motion drive comprising a drive screw and configured to translate the needle selectively in either proximal and distal direction along a translation axis, and further configured such that, when the apparatus is operably engaged with the tissue, the drive screw remains translationally stationary relative to the tissue during operation of the rotation motion drive to longitudinally translate the needle; and wherein the rotary motion drive and the linear motion drive are independently operatable.

IPC Classes  ?

  • A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
  • A61M 5/31 - Syringes Details
  • A61M 5/178 - Syringes
  • A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
  • A61F 9/007 - Methods or devices for eye surgery
  • A61M 5/34 - Constructions for connecting the needle
  • A61B 17/06 - NeedlesHolders or packages for needles or suture materials
  • A61M 5/24 - Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic

71.

AN OCULAR ACOUSTIC DEVICE AND A METHOD THEREOF

      
Application Number IL2021050862
Publication Number 2022/013871
Status In Force
Filing Date 2021-07-14
Publication Date 2022-01-20
Owner
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD (Israel)
  • BAR ILAN UNIVERSITY (Israel)
Inventor
  • Skaat, Alon
  • Leshno, Ari
  • Kenigsberg, Avraham
  • Shpaisman, Hagay

Abstract

The present invention enables assisting in manipulation and movement of intraocular particles in order to treat various ocular conditions. It enables controlling intra-ocular particles using acoustic wave forces. The novel technique of the present invention utilizes acoustic radiation forces for non-invasive control over movement of the pathologic intraocular particles, preventing them from unwanted accumulation and obstruction of intraocular structures, or causing visual disturbances. Acoustic forces can be harnessed to non-invasively organize various types of endogenous and exogenous particles within the anterior chamber of the eye, without any sign of tissue damage.

IPC Classes  ?

  • A61F 9/007 - Methods or devices for eye surgery
  • A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand

72.

Systems and methods for the segmentation of multi-modal image data

      
Application Number 17487082
Grant Number 11699236
Status In Force
Filing Date 2021-09-28
First Publication Date 2022-01-13
Grant Date 2023-07-11
Owner
  • Ramot at Tel-Aviv University Ltd. (Israel)
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Avital, Yitzhak
  • Kiryati, Nahum
  • Konen, Eli
  • Mayer, Arnaldo

Abstract

There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output. The intermediate outputs are inputted into a single common decoding-expanding component for computing the indication of segmented 3D ROI(s).

IPC Classes  ?

  • G06T 7/11 - Region-based segmentation
  • A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
  • A61B 34/32 - Surgical robots operating autonomously
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
  • G06N 3/08 - Learning methods

73.

A FALLOPIAN TUBE RETRIEVABLE DEVICE

      
Application Number IL2021050634
Publication Number 2021/245653
Status In Force
Filing Date 2021-05-27
Publication Date 2021-12-09
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Cohen, Shlomi
  • Ben David, Tamir
  • Sivan, Tovy

Abstract

A contraceptive device is provided including an occluding component for deployment in a tubal lumen of a reproductive organ. The device includes an expandable frame reversibly expandable from a collapsed state to an expanded state and a barrier supported by the expandable frame. In the expanded state the barrier is disposed between the expandable frame and walls of the lumen to inhibit in-growth of cellular material into and onto the occluding component, and additionally the barrier is urged against walls of the tubal lumen to define at least two tube lumen sealing areas, disposed perpendicular to a longitudinal axis of the walls of the tube lumen such that (i) the expandable frame is disposed between the two tubal lumen sealing surface, and (ii) passage of reproductive cells through the expandable frame, and through the tube lumen is blocked, therefore, creating a the complete blockage for liquids from a first part of the tube to a second part of the tube, downstream the first part. Other applications are also described.

IPC Classes  ?

  • A61F 6/22 - Vas deferens occludersFallopian occluders implantable in tubes
  • A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
  • A61F 2/30 - Joints
  • A61B 17/42 - Gynaecological or obstetrical instruments or methods

74.

METHOD FOR DELIVERY OF COMPOSITIONS TO THE EYE

      
Application Number 17391227
Status Pending
Filing Date 2021-08-02
First Publication Date 2021-11-18
Owner Tel Hashomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor Rotenstreich, Ygal

Abstract

The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.

IPC Classes  ?

  • A61F 9/009 - Auxiliary devices for making contact with the eyeball and coupling-in laser light
  • A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
  • A61F 9/008 - Methods or devices for eye surgery using laser

75.

System and method for determining oxygenated- blood content of biological tissue

      
Application Number 17272645
Grant Number 12262993
Status In Force
Filing Date 2019-08-27
First Publication Date 2021-11-04
Grant Date 2025-04-01
Owner Tel Hashomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Kostenich, Genady
  • Orenstein, Arie
  • Oron-Herman, Mor

Abstract

Some embodiments are directed to a system and method monitoring oxygenation in biological tissue, comprising a control unit configured and operable to receive data indicative of light response from a region of the biological tissue being subjected to illumination and/or collection at two separate wavelengths in two selected wavelength ranges and processing the data by comparing data indicative of each selected wavelength range to determine an oxygenated/deoxygenated status of the biological tissue. The two wavelength ranges include a first wavelength range in which the absorbance of the deoxyhemoglobin within the tissue is higher than the oxyhemoglobin, and a second wavelength range in which the absorbance of the oxyhemoglobin within the tissue is higher than the deoxyhemoglobin or vice versa. The two wavelengths in the two wavelength ranges include first and second wavelengths satisfying a predetermined condition of a ratio between the absorbance of the deoxyhemoglobin and oxyhemoglobin for each wavelength.

IPC Classes  ?

  • A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

76.

LUNG AIRWAY CLEARANCE

      
Application Number IL2021050457
Publication Number 2021/214769
Status In Force
Filing Date 2021-04-22
Publication Date 2021-10-28
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Ashkenazi, Moshe
  • Sokol, Gil
  • Efrati, Ori

Abstract

A system for providing treatment adapted to clear lung airways, the system including at least one pressure applicator adapted, when activated, to apply pressure at at least one specific location on a torso of a patient, and, when deactivated, to release the pressure, a sensor for sensing a signal associated with the patient, and, a controller, in communication with the sensor, adapted to analyze the signal and to control activation and deactivation of the at least one pressure applicator based, at least in part, on analyzing the signal. Related apparatus and methods are also described.

IPC Classes  ?

  • A61B 7/00 - Instruments for auscultation
  • A61H 23/04 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with hydraulic or pneumatic drive
  • A61H 9/00 - Pneumatic or hydraulic massage
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

77.

APPARATUS AND METHODS FOR CREATING AN ISOLATED PATIENT ENVIRONMENT

      
Application Number IB2021053217
Publication Number 2021/214634
Status In Force
Filing Date 2021-04-19
Publication Date 2021-10-28
Owner
  • TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • SYNERGY R.M LTD (Israel)
Inventor
  • Orkin, Dr. Dina
  • Librus, Michael

Abstract

Apparatus and methods are described for isolating at least a portion of a patient's body from the patient's surroundings. A patient-isolation device (20) includes a transparent screen (22) configured to be positioned in front of the patient's face. A flexible drape (26) is configured to hang around at least the portion of the patient's body, and to thereby isolate at least the portion of the patient's body from the patient's surroundings. Other applications are also described.

IPC Classes  ?

  • A61B 46/20 - Surgical drapes specially adapted for patients
  • A61B 46/00 - Surgical drapes
  • A61B 90/40 - Apparatus fixed or close to patients specially adapted for providing an aseptic surgical environment

78.

DECOY TRANSCRIPTS FOR TREATMENT OF ssRNA VIRAL INFECTION

      
Application Number IL2021050413
Publication Number 2021/209984
Status In Force
Filing Date 2021-04-11
Publication Date 2021-10-21
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Giat, Eitan
  • Giat, Yahel
  • Goldstein, Itamar

Abstract

There is provided a decoy transcript derived from a ss RNA virus (WV), the transcript comprising at least one of a 5'UTR of the WV, a genomic packaging signal (GPS) of the WV, a 3'UTR of the WV, and an exogenous stop codon.

IPC Classes  ?

79.

UPGRADING A BiPAP DEVICE TO A VENTILATOR SYSTEM FOR TREATING ACUTE RESPIRATORY DISTRESS SYNDROME

      
Application Number IL2021050417
Publication Number 2021/209988
Status In Force
Filing Date 2021-04-12
Publication Date 2021-10-21
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Sheps, Tal
  • Zabtani, Amit

Abstract

A system for ventilating a patient with an air and oxygen mix, the system including a BiPAP device, an oxygen source, and a monitoring unit for monitoring ventilation parameters. A method for providing an air and oxygen mix, the method including providing air using a BiPAP device, providing oxygen, mixing the air and the oxygen, monitoring ventilation parameters, and providing the air and oxygen mix. Related apparatus and methods are also described.

IPC Classes  ?

  • A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
  • A61M 16/10 - Preparation of respiratory gases or vapours
  • A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
  • A61M 16/20 - Valves specially adapted to medical respiratory devices

80.

METHODS OF DETERMINING ACTIVITY OF ACTIVATED PROTEIN C

      
Application Number IL2021050355
Publication Number 2021/199037
Status In Force
Filing Date 2021-03-29
Publication Date 2021-10-07
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Chapman, Joab
  • Shavit Stein, Efrat
  • Golderman, Valeria
  • Maggio, Nicola
  • Dori, Amir

Abstract

A method of determining activity of activated protein C (aPC) is provided. The method comprising: (a) contacting a biological sample with a substrate of the aPC, the substrate comprising a detectable moiety, and wherein the contacting is under conditions in which activity of thrombin and activity of Factor Xa (FXa) are inhibited; (b) determining an amount of the detectable moiety formed as a result of a catalytic hydrolytic action of the aPC, the amount being indicative of the activity of the aPC.

IPC Classes  ?

  • C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
  • C12N 15/52 - Genes encoding for enzymes or proenzymes
  • A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
  • G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
  • G01N 33/535 - Production of labelled immunochemicals with enzyme label
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
  • C12Q 1/25 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving enzymes not classifiable in groups
  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood coagulating time

81.

MITOCHONDRIA-ENRICHED GENETICALLY ENGINEERED CELLS AND USES THEREOF

      
Application Number IL2021050358
Publication Number 2021/199040
Status In Force
Filing Date 2021-03-30
Publication Date 2021-10-07
Owner
  • MINOVIA THERAPEUTICS LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Yivgi-Ohana, Natalie
  • Sher, Noa
  • Blumkin, Moriya
  • Jacoby, Elad

Abstract

The present invention is based on the discovery that cells enriched with mitochondria are useful for treating diseases and disorders. Disclosed are pharmaceutical compositions of mitochondrially-enriched genetically engineered T cells and methods of treatment using mitochondrially-enriched genetically engineered T cells.

IPC Classes  ?

  • A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
  • A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
  • A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
  • C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
  • C12N 5/22 - Human cells

82.

MITOCHONDRIA-ENRICHED GENETICALLY ENGINEERED CELLS AND USES THEREOF

      
Document Number 03172402
Status Pending
Filing Date 2021-03-30
Open to Public Date 2021-10-07
Owner
  • TEL HASHOMER-MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • MINOVIA THERAPEUTICS LTD. (Israel)
Inventor
  • Yivgi-Ohana, Natalie
  • Sher, Noa
  • Blumkin, Moriya
  • Jacoby, Elad

Abstract

The present invention is based on the discovery that cells enriched with mitochondria are useful for treating diseases and disorders. Disclosed are pharmaceutical compositions of mitochondrially-enriched genetically engineered T cells and methods of treatment using mitochondrially-enriched genetically engineered T cells.

IPC Classes  ?

  • A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
  • A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells

83.

SYSTEM, DEVICE AND METHOD FOR DETERMINING AND/OR ASSESSING BRAIN RELATED CONDITIONS BASED ON PUPIL LIGHT RESPONSE

      
Application Number IL2021050170
Publication Number 2021/161318
Status In Force
Filing Date 2021-02-11
Publication Date 2021-08-19
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Rotenstreich, Ygal
  • Sher, Ifat

Abstract

Provided herein are systems, devices and methods for monitoring the progression of, determining and/or assessing brain related conditions in a subject based on pupil light responses (PLRs) to chromatic light stimuli, in particular, by classifying the PLR based on one or more PLR parameter values, wherein the classifying allows monitoring the progression of, determining and/or assessing the brain related condition

IPC Classes  ?

  • A61B 3/11 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring interpupillary distance or diameter of pupils
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes

84.

PROCESS FOR KIDNEY CELL MANUFACTURE AND TREATMENT

      
Document Number 03164358
Status Pending
Filing Date 2021-01-25
Open to Public Date 2021-08-05
Owner
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • KIDNEYCURE LTD (Israel)
Inventor
  • Simanovsky, Masha
  • Dekel, Benjamin

Abstract

Embodiments described herein relate to a method for preparing cultured cells, the method comprising: obtaining kidney tissue from a human subject; mechanically dissociating the tissue; subjecting the tissue to enzymatic digestion; incubating the tissue with media in a cell culture plate to form cultured cells.

IPC Classes  ?

  • A61K 35/22 - UrineUrinary tract, e.g. kidney or bladderIntraglomerular mesangial cellsRenal mesenchymal cellsAdrenal gland
  • A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
  • A61L 27/38 - Animal cells
  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

85.

Compositions and methods for treating glioblastoma

      
Application Number 17050910
Grant Number 11497793
Status In Force
Filing Date 2019-04-16
First Publication Date 2021-07-29
Grant Date 2022-11-15
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Chapman, Joab
  • Shavit-Stein, Efrat

Abstract

Compositions and methods for treating malignant gliomas such as glioblastoma are provided, comprising a combination of a peptide conjugate comprising an amino acid sequence derived from the N-terminus of the receptor PAR-1, and the chemotherapeutic agent temozolomide.

IPC Classes  ?

  • A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
  • A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
  • A61P 35/00 - Antineoplastic agents
  • A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
  • A61K 38/06 - Tripeptides
  • A61K 38/08 - Peptides having 5 to 11 amino acids

86.

Ocular surgical instrument

      
Application Number 17271189
Grant Number 11911018
Status In Force
Filing Date 2019-08-29
First Publication Date 2021-06-24
Grant Date 2024-02-27
Owner TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor Leshno, Ari

Abstract

Apparatus for performing an ocular surgery, the apparatus comprising: a support housing having a bottom configured to be positioned on the sclera of an eye during performance of an ocular surgery; a muscle hook holder connected to the support housing and configured to hold an ocular muscle hook so that the ocular muscle hook is translatable to elevate an ocular muscle away from the eye during performance of the surgery; and a set of graduation markings on the support housing useable to determine a distance that the ocular muscle hook is translated to elevate the ocular muscle.

IPC Classes  ?

  • A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors
  • A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
  • A61B 17/00 - Surgical instruments, devices or methods

87.

Formation of functionalized cancer targeting nanoparticles by supramolecular co-assembly

      
Application Number 16071168
Grant Number 11389544
Status In Force
Filing Date 2017-01-19
First Publication Date 2021-06-10
Grant Date 2022-07-19
Owner
  • RAMOT AT TEL-AVIV UNIVERSITY LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Shekhter Zehavi, Talia
  • Gazit, Ehud
  • Herman-Oron, Mor
  • Kostenich, Genady
  • Orenstein, Arie

Abstract

The present invention provides nanoparticle conjugates incorporating the self-assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanospheres. The present invention further provides nanoparticles formed by supramolecular co-assembly of the conjugates with a diphenylalanine (FF) dipeptide or analog thereof, to generate bioactive self-assembled nanostructures.

IPC Classes  ?

  • A61P 35/00 - Antineoplastic agents
  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
  • A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
  • A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
  • A61K 38/31 - Somatostatins

88.

THREE DIMENSIONAL CLUSTERS OF TRANSDIFFERENTIATED CELLS, COMPOSITIONS AND METHODS THEREOF

      
Application Number 16978196
Status Pending
Filing Date 2019-03-06
First Publication Date 2021-06-10
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Assa Kunik, Efrat
  • Cohen, Smadar
  • Monsonego, Alon
  • Ferber, Sarah

Abstract

The present disclosure provides compositions and methods for providing a cell replacement therapy to treat various diseases, including pancreatic diseases and diabetes. Specifically, the disclosure provides three-dimensional (3D) cell clusters of transdifferentiated insulin producing cells attached to scaffolds, such as a polysaccharide matrix, in order to provide a cell replacement therapy.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
  • A61K 38/18 - Growth factorsGrowth regulators
  • A61K 38/20 - Interleukins

89.

Compositions targeting GABRA2 and methods for diagnosis and treatment of cancer

      
Application Number 17263251
Grant Number 12134650
Status In Force
Filing Date 2019-07-25
First Publication Date 2021-06-03
Grant Date 2024-11-05
Owner
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
  • Tageza Biopharmaceuticals Ltd. (Israel)
Inventor
  • Dekel, Benjamin
  • Harari-Steinberg, Orit
  • Goldberg, Sanja

Abstract

Methods of treating cancer are provided. Accordingly, there is provided a method of treating cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an agent capable of (i) specifically binding GABRA2, the agent comprising a therapeutic moiety; and/or (ii) downregulating activity and/or expression of said GABRA2. Also provided are compositions, article of manufactures and methods of diagnosing cancer and monitoring cancer treatment.

IPC Classes  ?

  • A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
  • A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

90.

Mammography apparatus

      
Application Number 17163934
Grant Number 11534126
Status In Force
Filing Date 2021-02-01
First Publication Date 2021-05-27
Grant Date 2022-12-27
Owner Tel HaShomer Medical Research, Infrastructure and Services Ltd. (Israel)
Inventor
  • Sklair-Levy, Miriam
  • Mayer, Arnaldo
  • Pfeffer, Shmuel Yitzhak

Abstract

Apparatus for diagnosing breast cancer, the apparatus comprising a controller having a set of instructions executable to: acquire a contrast enhanced region of interest (CE-ROI) in an X-ray image of a patient's breast, the X-ray image comprising X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image; determine a texture neighborhood for each of a plurality of X-ray pixels in the CE-ROI, the texture neighborhood for a given X-ray pixel of the plurality of X-ray pixels extending to a bounding pixel radius of BPR pixels from the given pixel; generate a texture feature vector (TF) having components based on the indications of intensity provided by a plurality of X-ray pixels in the CE-ROI that are located within the texture neighborhood; and use a classifier to classify the texture feature vector TF to determine whether the CE-ROI is malignant.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • G06T 7/11 - Region-based segmentation
  • G06T 7/13 - Edge detection
  • A61B 6/04 - Positioning of patientsTiltable beds or the like
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • G06V 10/46 - Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]Salient regional features
  • G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
  • G06V 10/50 - Extraction of image or video features by performing operations within image blocksExtraction of image or video features by using histograms, e.g. histogram of oriented gradients [HoG]Extraction of image or video features by summing image-intensity valuesProjection analysis
  • G06V 10/42 - Global feature extraction by analysis of the whole pattern, e.g. using frequency domain transformations or autocorrelation
  • G06T 7/44 - Analysis of texture based on statistical description of texture using image operators, e.g. filters, edge density metrics or local histograms
  • A61B 6/12 - Arrangements for detecting or locating foreign bodies

91.

Endotracheal tube cleaning device system and method

      
Application Number 16972601
Grant Number 11547525
Status In Force
Filing Date 2019-06-06
First Publication Date 2021-04-22
Grant Date 2023-01-10
Owner
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • THE MEDICAL RESEARCH INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER (Israel)
Inventor
  • Shinfeld, Amihay
  • Paz, Yoav
  • Mendes, Emanuel
  • Feldman, Joseph

Abstract

An endotracheal tube cleaning device, including a rod, and a cleaning head coupled to a distal end of the rod, including a low friction-generating surface; and a high friction-generating surface, wherein the low friction-generating surface contacts an inner surface of the endotracheal tube when moved along the tube in a first direction and the high friction-generating surface contacts the inner surface of the endotracheal tube when moved in a second, opposite direction.

IPC Classes  ?

  • A61B 90/70 - Cleaning devices specially adapted for surgical instruments
  • A61M 25/00 - CathetersHollow probes
  • B08B 9/043 - Cleaning the internal surfacesRemoval of blockages using cleaning devices introduced into and moved along the pipes moved by externally powered mechanical linkage, e.g. pushed or drawn through the pipes
  • A61M 16/04 - Tracheal tubes

92.

COMPOSITIONS TARGETING GPM6A AND METHODS FOR DIAGNOSIS AND TREATMENT OF CANCER

      
Application Number IL2020050864
Publication Number 2021/024263
Status In Force
Filing Date 2020-08-06
Publication Date 2021-02-11
Owner
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
  • TAGEZA BIOPHARMACEUTICALS LTD. (Israel)
Inventor
  • Dekel, Benjamin
  • Harari-Steinberg, Orit

Abstract

Methods of treating cancer are provided. Accordingly, there is provided a method of treating cancer in a subject in need thereof, wherein the cancer is not malignant rhabdoid tumor (MRT) and not atypical teratoid/rhabdoid tumor (ATRT), the method comprising administering to the subject an effective amount of an agent capable of (i) specifically binding GPM6A, the agent comprising a therapeutic moiety; and/or (ii) downregulating activity and/or expression of said GPM6A. Also provided a method of treating a metastatic, a relapsed and/or an aggressive cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an agent capable of (i) specifically binding GPM6A, the agent comprising a therapeutic moiety; and/or (ii) downregulating activity and/or expression of said GPM6A. Also provided are compositions, article of manufactures and methods of diagnosing cancer and monitoring cancer treatment.

IPC Classes  ?

  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 49/00 - Preparations for testing in vivo
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61P 35/04 - Antineoplastic agents specific for metastasis
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

93.

METHODS OF TREATING NON-INFECTIOUS INFLAMMATORY DISORDERS

      
Application Number IL2020050866
Publication Number 2021/024265
Status In Force
Filing Date 2020-08-06
Publication Date 2021-02-11
Owner
  • RAMOT AT TEL-AVIV UNIVERSITY LTD. (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Leor, Jonathan
  • Konfino, Tal
  • Rotem, Itai

Abstract

The present invention relates to an Osteopontin protein or a functional analog thereof, compositions and kits comprising the same and methods for the treatment of non-infectious inflammatory disorders.

IPC Classes  ?

  • A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
  • A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
  • A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
  • A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
  • A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
  • A61K 9/00 - Medicinal preparations characterised by special physical form

94.

METHODS AND KITS FOR IDENTIFYING THROMBUS ORIGIN AND OPTIMIZING POST-ISCHEMIC EVENT TREATMENT

      
Application Number IL2020050816
Publication Number 2021/019529
Status In Force
Filing Date 2020-07-23
Publication Date 2021-02-04
Owner TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Orion, David
  • Itsekson-Hayosh, Zeev
  • Shavit-Stein, Efrat
  • Chapman, Joab

Abstract

Provided herein are method and kits for identifying thrombus origin based on temporal thrombin activity assay, and use thereof for optimizing post-ischemic event treatment, and further preventing recurrence of secondary ischemic events.

IPC Classes  ?

  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood coagulating time
  • C12Q 1/56 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
  • G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper

95.

DEVICE AND METHOD FOR SPECTRAL IMAGING

      
Application Number IL2020050827
Publication Number 2021/014455
Status In Force
Filing Date 2020-07-24
Publication Date 2021-01-28
Owner
  • BAR-ILAN UNIVERSITY (Israel)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Garini, Yuval
  • Bronshtein-Berger, Irena
  • Barshack, Iris

Abstract

A spectral imaging device includes an imager, a scanning stage to establish relative motion between the imager and a sample in a scanning direction and an optical system controlling a light characteristic of a light beam constituting an image of the sample to the imager. The optical system includes a light varying element to receive the light beam and provide an output light beam with spatially varying light characteristic over a cross-section thereof. A set of redirecting optical elements direct light rays from the sample to form the light beam, and to focus the output light beam onto the imager. A controller controls the scanning stage and the imager to capture a plurality of image frames with an overlap including a defined shift that is greater than 1 pixel along the scanning direction between consecutive image frames. A computing device consolidates image data to provide an image of the sample.

IPC Classes  ?

  • G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
  • G01J 3/28 - Investigating the spectrum
  • H04N 5/33 - Transforming infrared radiation
  • A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion

96.

CHORDA REPLACEMENT APPARATUS AND METHOD

      
Application Number IL2020050745
Publication Number 2021/001837
Status In Force
Filing Date 2020-07-03
Publication Date 2021-01-07
Owner TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Serraf, Alain Elie
  • Tejman-Yarden, Mila Shai Raziel
  • Shafrir, Roey

Abstract

Apparatus for coupling a prosthetic chorda to an atrioventricular valve leaflet, the apparatus comprising: a neochorda delivery system comprising a steerable and pushable catheter housing a neochorda attached to a neochorda puncture needle, the catheter operable to push the puncture needle to puncture and thread the neochorda through a papillary muscle of a ventricle; a retriever system comprising a catheter housing a grabber operable to capture the neochorda puncture needle after being threaded through the papillary muscle and withdraw the neochorda puncture needle and neochorda from the ventricle; and a tissue clamping system comprising a catheter housing distal and proximal tissue clamps deployable to clamp a region of an atrioventricular valve between them and hold the region so that it may be punctured by the puncture needle to deliver the neochorda through the leaflet and to the papillary muscle.

IPC Classes  ?

97.

Systems and methods for the segmentation of multi-modal image data

      
Application Number 16959693
Grant Number 11170508
Status In Force
Filing Date 2019-01-03
First Publication Date 2020-12-03
Grant Date 2021-11-09
Owner
  • Ramot at Tel-Aviv University Ltd. (Israel)
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
Inventor
  • Avital, Yitzhak
  • Kiryati, Nahum
  • Konen, Eli
  • Mayer, Arnaldo

Abstract

There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output. The intermediate outputs are inputted into a single common decoding-expanding component for computing the indication of segmented 3D ROI(s).

IPC Classes  ?

  • G06T 7/11 - Region-based segmentation
  • G06N 3/08 - Learning methods
  • A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
  • A61B 34/32 - Surgical robots operating autonomously
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques

98.

Magnetic resonance maps for analyzing brain tissue

      
Application Number 16992160
Grant Number 11933866
Status In Force
Filing Date 2020-08-13
First Publication Date 2020-11-26
Grant Date 2024-03-19
Owner
  • Tel Hashomer Medical Research Infrastructure and Services Ltd. (Israel)
  • Ramot at Tel-Aviv University Ltd. (Israel)
Inventor
  • Mardor, Yael
  • Zach, Leor
  • Guez, David
  • Last, David
  • Daniels Elmakias, Dianne

Abstract

Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.

IPC Classes  ?

  • G01R 33/28 - Details of apparatus provided for in groups
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • G01R 33/48 - NMR imaging systems
  • G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
  • G06T 7/00 - Image analysis
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
  • A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
  • A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid

99.

Magnetic resonance maps for analyzing tissue

      
Application Number 16992163
Grant Number 11892530
Status In Force
Filing Date 2020-08-13
First Publication Date 2020-11-26
Grant Date 2024-02-06
Owner
  • Tel HaShomer Medical Research Infrastructure and Services Ltd. (Israel)
  • Ramot at Tel-Aviv University Ltd. (Israel)
Inventor
  • Mardor, Yael
  • Zach, Leor
  • Guez, David
  • Last, David
  • Daniels Elmakias, Dianne

Abstract

Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.

IPC Classes  ?

  • G01R 33/28 - Details of apparatus provided for in groups
  • G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
  • G01R 33/48 - NMR imaging systems
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/00 - Image analysis
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
  • A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
  • A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol

100.

ANTI-HVEM ANTIBODIES AND USE THEREOF

      
Document Number 03135536
Status Pending
Filing Date 2020-04-28
Open to Public Date 2020-11-05
Owner
  • 4C BIOMED LIMITED (United Kingdom)
  • TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. (Israel)
Inventor
  • Greenberg, Eyal
  • Galore-Haskel, Gilli
  • Merhavi-Shoham, Efrat
  • Markel, Gal
  • Schachter, Jacob

Abstract

Agents that bind HVEM, inhibit HVEM-BTLA interaction and activate downstream HVEM signaling are provided. Methods of treating disease with those agents and kits comprising those agents are also provided.

IPC Classes  ?

  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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