A method of treating an isolated area of a sample with a liquid is disclosed. The method has the steps of generating an isolated area of a sample by a first fluid reservoir where the first fluid reservoir enclosing a distal end of a second fluid reservoir and the isolated area of the sample being sealed towards the remaining area of the sample, bringing the isolated area of the sample into fluid connection with the second fluid reservoir, dispensing a fluid from the second fluid reservoir into the first fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a first direction, and aspirating the fluid from the first fluid reservoir into the second fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a second direction.
A method for separating particles (64) with a laboratory automation device (10) comprises: mounting a particle separator (20) to a pipetting arm (14) of the laboratory automation device (10), wherein a first pipette tip (18a) and a second pipette tip (18b) are connected to the pipetting arm (14), wherein the particle separator (20) is mounted by inserting the first pipette tip (18a) into a first receptacle (40a) and the second pipette tip (18b) into a second receptacle (40b) of the particle separator (20); generating a pressure difference between a first chamber (58a) and a second chamber (58b) of the particle separator (20), such that a suspension (62) inside the first chamber (58a) and the second chamber (58b) is moved through a connection channel (60) interconnecting the first chamber (58a) and the second chamber (58b), wherein the first chamber (58a) is interconnected with the first receptacle (40a) and the second chamber (58b) is interconnected with the second receptacle (40b) and wherein different pressures are applied to the first chamber (58a) and the second chamber (58b) via the first pipette tip (18a) and the second pipette tip (18b), which are connected to at least one pressure generator (32) of the laboratory automation device (10); determining an impedance signal (76) indicative of an impedance of the suspension (62) inside the connection channel (60) with a measurement device (34) of the laboratory automation device (10); and detecting a particle (64) in the suspension (62) passing the connection channel (60) by evaluating the impedance signal (76).
G01N 15/12 - Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
A microfluidic device (22) for a laboratory automation device (10) comprises a first tapered receptacle (40a), a second tapered receptacle (40b) and a channel (48) interconnecting the first tapered receptacle (40a) and the second tapered receptacle (40b).
A solid phase extraction apparatus with a base plate and a shuttle horizontally moveable along the base plate configured to transport a labware component. A pressure manifold plate reciprocally moveable vertical thereby defining an elevator shaft; the shuttle being moveable into and out of the elevator shaft for positioning the labware component below the manifold plate. A reagent dispenser vertically moveable together with the manifold plate with a swivel arm and a hinge coupling one end of the swivel arm to the manifold plate. A dispensing tube located at the other end forming a lumen being fluidly coupled to the liquid reagent. A drive mechanism for rotating the one end of the swivel arm around the hinge thereby moving the dispensing tube from a position within the elevator shaft to a position outside the elevator shaft for dispensing liquid reagent into the labware component.
Multi-port rotary slide valve, comprising a port plate (1) with a central common port (100) and at least three peripheral ports (101; 102; 103) that are arranged on a circle around the common port (100), further comprising a connection plate (2), which can be rotated around a first axis (A1) by a first drive (5) and which comprises a connection channel (200), wherein the connection channel (200) extends from one side of the intersection of the first axis (A1) with the port plate to a side opposite thereof and has a minimal length that corresponds to the radius of the circle the peripheral ports (101;102;103) are arranged on, wherein an excentre mechanism (3) with a second drive (6) is provided, with which, a relative movement perpendicular to the first axis (A1) between the port plate (1) and the connection plate (2) can be effected.
F16K 11/078 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted and linearly movable closure members
F16K 31/52 - Mechanical actuating means with crank, eccentric, or cam
6.
PARTICLE SEPARATOR FOR A LABORATORY AUTOMATION DEVICE
A particle separator (20) for a laboratory automation device (10) comprises a first tapered receptacle (40a) and a second tapered receptacle (40b); a first chamber (58a) below the first tapered receptacle (40a) and a second chamber (58b) below the second tapered receptacle (40b); a connection channel (60) interconnecting the first chamber (58a) and the second chamber (58b); and an outlet channel (54) connected to the second chamber (58a).
G01N 15/12 - Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
A uniaxial coupling device comprising a head (1) and a holder (2) that are movable relative to each other, and a first abutment (24) and a second abutment (25) that that are stationary with respect to the holder (2), wherein the head (1) comprises at least one connector (12) that is displaceable between a first position (P12.1) and a second position (P12.2), wherein the holder (2) comprises at least one reception (23) for an attachment (3) to be coupled to the head (1) that is displaceable between a first position (P23.1) and a second position (P23.2), wherein when an attachment (3) is arranged on the reception (23), a magnetizable first coupling surface (120) of the connector (12) abuts a magnetic second coupling surface (330) on the attachment (3), while the connector (12) abuts the first abutment (24), when the connector (12) and the reception (23) are in their first positions.
A labware lift comprising a head lift (5) mounted on a base plate (40) that extends in a first horizontal direction (X) and in a second horizontal direction (Y) that is perpendicular to the first horizontal direction (X), wherein the head lift (5) comprises a first platform (50) that is movable in a vertical direction (Z) and that is guided by at least one lift rail (42), wherein the at least one lift rail (42) is mounted on one lateral side of the base plate (40) in the first horizontal direction (X), wherein the labware lift further comprising a stack lift (7) mounted on the base plate (40), wherein the stack lift (7) comprises a second platform (70) that is movable in the vertical direction (Z) between the base plate (40) and the first platform (50) and that is guided by the same at least one lift rail (42).
Multi-port linear slide valve, comprising a port plate (1) with at least three linear ports (100;101;102) that are arranged in a first direction (X), and extending through the port plate from a front surface to a back surface, a connection plate (2) with a common port (200), extending through the connection plate from the a frontal contact surface to a back surface, wherein the connection plate lies on the port plate, allowing a relative movement of the connection plate with respect to the port plate, a first drive (3), with which a relative movement in the first direction between the port plate and the connection plate can be effected, and a second drive (4), with which a relative movement in a second direction (Y) between the port plate and the connection plate can be effected.
F16K 11/065 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with linearly sliding closure members
10.
MICROPLATE PROCESSING APPARATUS AND LID PLACEMENT METHOD USING THE APPARATUS
A microplate processing apparatus comprising a working table, a microplate having a rectangular top surface, a rectangular lid for covering the top surface of the microplate with a rim adapted to surround the top surface of the microplate. A transfer mechanism with a gripper configured to grip and place the lid to different positions on the working table and a microcontroller for controlling the transfer mechanism. The microplate processing apparatus is configured to place the lid onto the microplate where the centers of the lid is misaligned with the center of the top surface of the microplate such that a part of the rim touches the top surface. The apparatus is configured to move the lid in the x-y plane on, or across the top surface thereby self-aligning the centers of the lid and the microplate such that the rim surrounds the microplate.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
The invention relates to a robotic sample handling apparatus for performing sample handling tasks in a laboratory environment, comprising a worktable for holding samples and a robot arm (130) which is controllable to be positioned in a horizontal XY plane parallel to the worktable and along a vertical Z-axis perpendicular to the worktable. The robot arm comprises a housing part (132) that is slidingly mounted to a support arm (120) of the apparatus and further comprises an upper assembly, which is mounted to the housing part (132) so as to be displaceable between a raised position and a lowered position. The upper assembly includes a top plate (133), a base plate (135) and an arrangement of at least one first guide rod (136, 137) and at least one second guide rod (138), which extend in vertical direction Z therebetween. The upper assembly is slidingly mounted to the housing part (132) via a corresponding at least one first linear bearing (141, 142) through which the corresponding first guide rod (136,137) extends. The robot arm further comprises a telescoping plate (150) that is slidingly mounted to the upper assembly via a corresponding at least one second linear bearing (143, 144) through which the corresponding second guide rod (138) extends.
METHOD, COMPUTER PROGRAM AND LABORATORY AUTOMATION DEVICE FOR TREATING TWO OR MORE PROBE SLICES, CONTROLLER FOR CONTROLLING THE LABORATORY AUTOMATION DEVICE, AND COMPUTER-READABLE MEDIUM
A method for treating a first probe slice (70) and at least a second probe slice (72) by a laboratory automation device (10) is described. The first probe slice (70) is arranged on a first object slide (54) and the second probe slice (72) is arranged on a second object slide (56). The first and second object slides (54, 56) are arranged on an upper surface (51, 53) of a carrier (50, 52), wherein the upper surface (51, 53) of the carrier (50, 52) defines a plane extending in a first direction (40) and in a second direction (42) perpendicular to the first direction (40). The laboratory automation device (10) comprises a handling system (15) having a treatment arm (20) and first and second treatment tool (30, 32) movably arranged at the treatment arm (20). The method comprises: determining positions of a first area of interest (74) of the first probe slice (70) and of a second area of interest (76) of the second probe slice (72) with respect to the first and second directions (40, 42); generating a handling signal and a movement signal depending on the determined positions of the areas of interest (74, 76); sending the handling signal to the handling system (15), wherein the handling signal and the handling system (15) are configured such that upon receiving the handling signal the handling system (15) moves the first object slide (54) in the first direction (40) until the first area of interest (74) overlaps the second area of interest (76) in the first direction (40); sending the movement signal to the handling system (15), wherein the movement signal and the handling system (15) are configured such that upon receiving the movement signal the handling system (15) moves the treatment arm (20) parallel to the first direction (40) until a first treatment spot (80) of the first treatment tool (30) overlaps the first area of interest (74) in the first direction (40) and a second treatment spot (82) of the second treatment tool (32) overlaps the second area of interest (76) in the first direction (40), moves the first treatment tool (30) in a second direction (42) perpendicular to the first direction (40) until the first TC-0842P-EP / T0038P-EP 47 treatment spot (80) overlaps the first area of interest (74) in the second direction (42), and moves the second treatment tool (32) parallel to the second direction (42) until the second treatment spot (82) overlaps the second area of interest (76) in the second direction (42); and sending a treatment signal to the handling system (15), wherein the treatment signal and the handling system (15) are configured such that upon receiving the treatment signal the handling system (15) treats the first probe slice (70) in the first area of interest (74) by the first treatment tool (30) and the second probe slice (72) in the second area of interest (76) by the second treatment tool (32).
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Robot arms with pipetting devices and sampling devices; dispensers, pumps and dosing apparatus for laboratory use; disposable pipette tips for laboratory use; disposable materials for use in laboratory apparatus. Disposable materials for use in analytical apparatus and instruments for clinical diagnostic use and for veterinary use; disposable pipette tips for use in analytical apparatus and instruments for clinical diagnostic use and for veterinary use.
A pipette tip (10) comprises an elongated tubular body (12) with a head (14) for mounting the pipette tip (10) into a receptacle (52) of a pipetting device; wherein the tubular body (12) comprises an orifice (20) opposite to the head (14), whereby orifice (20) is connected via the tubular body (12) with an opening (16) in the head (14); wherein the head (14) comprises a sealing collar (24) surrounding the head (14); and wherein the sealing collar (24) is connected to the head (14) opposite to the orifice (20) and runs along the head (14) in direction to the orifice (20).
In one aspect, the invention relates to a robotic sample handling system comprising a controller and a robotic arm which is controllable to be positioned in a horizontal XY plane parallel to a work area and along a vertical Z-axis perpendicular to the work area. The work area comprises a module which is provided with a moveable element (550) for interacting with a sample container (170). The module is equipped with a mechanism, which comprises: - a first linear element (210) and a second linear element (220) which extend in vertical direction Z, and which are mounted to the module in a manner which enables each linear element to be moved in a downward and upward direction between a raised position and a lowered position; and - at least one rotor element (230) which engages with each of the first and second linear elements such that the application of downward force on one of the first and second linear elements, when in a raised position, causes: • displacement of that linear element in downward direction; • rotation of the at least one rotor element; and • displacement of the other linear element in upward direction. The moveable element (550) is mounted in connection with the rotor element and is displaceable between a first position and a second position. The controller is configured to control the robotic arm to displace the moveable element by pushing downward in Z-direction on one of the first and second linear elements, when in a raised position.
A guiding frame for a laboratory automation device comprises: a bottom side for placing the guiding frame on a component of the laboratory automation device; a top side with a position detection area; and an opening for accessing a port of the component, which opening is arranged besides the position detection area. The position detection area has two recesses, each recess having two straight edges, which from a view direction onto the top side are arranged inclined with respect to each other. The bottom side comprises alignment means for aligning the guiding frame with respect to the component, the alignment means comprising a base surface for contacting a top surface of the component and/or guiding surfaces for contacting walls of the component.
The present invention resides in a multichannel head of a pipetting device for aspirating and dispensing liquid via a plurality of pipetting tips. The multichannel head comprises a connector block (110) having an array of m*n connectors (120), whereby each connector comprises an internal passageway (125) that is fluidically connectable to a pipetting tip, and further includes a plunger block having a corresponding array of m*n channels. Each channel accommodates a plunger and has an opening that is fluidically connected to the internal passageway (125) of a corresponding connector. The multichannel head further comprises a sealing mat (150) arranged between the connector block (110) and the plunger block, wherein the sealing mat comprises a corresponding array of men annular sealing elements for providing an airtight seal of the fluidic connection between the internal passageway of each connector and each opening of the corresponding plunger channel. The annular sealing elements are interconnected by a lattice of linkages that extend in lateral direction and in longitudinal direction, such that a cut-out region is formed between two opposing lateral linkages and two opposing longitudinal linkages. The sealing mat (150) is arranged on a receiving surface (116), which is provided with protrusions (117) that are shaped to pass through the cut-out regions of the sealing mat.
A cooling module for receiving a plurality of containers has a housing that includes at least one opening, a cooling block arranged into the housing, at least one compartment for receiving the containers via the opening, and at least one cover for covering the opening against the exterior.
A hollow needle for piercing a closure of a sample vessel, wherein the hollow needle has a cylindrical hollow profile extending along a longitudinal axis and having a tip at a first end thereof, where the hollow needle has a first section that has a tip and a second section that has a larger diameter than the first section, and a transition between the first section and the second section has at least one cutting edge that extends from the first section to the second section.
Some embodiments are directed to a method for detaching tissue from a tissue section on a tissue slide. The method may include applying a 3D printed mask on top of the tissue section, the mask comprising barriers that define a cavity surrounding an area of interest on the tissue section, the cavity being open at a side facing the area of interest on the tissue section, dispensing a detaching liquid to the cavity, and allowing the detaching liquid to detach tissue at the area of interest, and aspirating the detaching liquid with the detached tissue from the cavity, and forwarding the liquid for further processing.
A method for aspirating a liquid with a laboratory automation device comprises: lowering a pipette of the laboratory automation device into a vessel containing the liquid; during lowering, generating an underpressure or overpressure in the pipette with a pressure generating device of the laboratory automation device and measuring a pressure in a pressure distribution system interconnecting the pressure generating device with the pipette; detecting a liquid surface of the liquid in the vessel by evaluating a pressure change of the pressure; calculating a compensation volume from compartment volumes of compartments of the pressure distribution system and/or of the pipette and from pressure losses between the compartments; and aspirating the liquid from the vessel into the pipette by controlling the pressure generating device to aspirate a specific volume altered by the compensation volume.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Software for controlling apparatus and instruments for
laboratories, for controlling medical apparatus and for the
analysis of measurement results; software for analysis of
images from tissue and cell imaging devices. Providing temporary use of non-downloadable software for
controlling apparatus and instruments for laboratories, for
controlling medical apparatus and for the analysis of
measurement results; Software as a service [SaaS] featuring
software for controlling apparatus and instruments for
laboratories, for controlling medical apparatus and for the
analysis of measurement results; creating back-up copies of
electronic data from absorption measuring apparatus,
luminescence measuring apparatus, fluorescence measuring
apparatus and from tissue and cell imaging devices.
09 - Scientific and electric apparatus and instruments
Goods & Services
Robots, namely, automatic apparatus for collecting,
distributing or positioning objects and solid, liquid or
gaseous substances. Scientific apparatus and instruments, namely, robots for
collecting, distributing, transporting or positioning of
objects and solid, liquid and gaseous substances; Scientific
apparatus and instruments, namely, pipetting devices and
sampling devices, dispensers and dosing apparatus.
A mixing apparatus containing a drive unit having a drive and a shaft that is pivotable about a pivot axis and is operatively connected to the drive. A pivotable receptacle is arranged on the shaft, where the pivot axis is oriented essentially horizontally, and the pivotable receptacle has a base plate and at least one retainer spaced therefrom, and the pivotable receptacle is configured in such a way that holders for containers can be inserted between the base plate and the at least one retainer in the direction of the pivot axis.
A method accurately positions a robotic manipulator at a target position of a target object in an automated sample handling device. An optical reference object is detectable by imaging located at a first position at a worksurface and a capacitive reference object is located at a second position at the worksurface. A position of the robotic manipulator relative to the second position is detectable by measurements of the electrical impedance/capacitance between the capacitive reference object and the robotic manipulator acting as a measuring probe. An image is then taken of the first reference object together with the target object to determine the target position and a current position of the robotic manipulator is determined based on electrical impedance/capacitance measurements taken at different locations of the capacitive reference object. The robotic manipulator is then moved from the determined current position to the determined target position.
A pipette tip adapter (1) is detachably connectable between a pipetting device (10) and a pipette tip (15). The pipette tip adapter has a body (2) with an interior compartment (7) for holding a liquid (18), a recess (3) entering into a part of the body (2) for detachably receiving a connector (11) of the pipetting device (10) and having a first opening (5) pneumatically connected with the interior compartment (7). The pipette tip adapter (1) further has a tube section (4) projecting from the pipette tip adapter (1) detachably securable with a pipette tip (15) and having a second opening (6) hydraulically connected with the interior compartment (7). The pipette tip adapter (1) may be used in an automated pipetting system (100). An automated pipetting system (100) having a pipette tip adapter (1) for preparing liquid reactions is also disclosed.
A method is proposed for determining fluid path connectivity in a fluidic system comprising a fluidic device (2) having at least a first channel (3) that forms at least part of a fluid path comprising an upstream portion and a downstream portion. The method comprises measuring an electrical quantity of or across the fluid path, in particular between the upstream portion and a reference potential (GND), and determining a degree of fluid path connectivity based on the measured electrical quantity. Furthermore, a fluidic system provided with a measuring arrangement (1) for determining fluid path connectivity is suggested and apparatuses for testing and calibrating a rotary valve and a linear valve are proposed.
F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
30.
TEMPERATURE EQUALIZING PLATE FOR A MICROPLATE READER AND MICROPLATE READER WITH SUCH A TEMPERATURE EQUALIZING PLATE
A temperature equalizing plate (1) for a micro plate reader (4), onto which temperature equalizing plate (1) a microplate with wells can be removably arranged, the temperature equalizing plate (1) having a plate-shaped body, wherein a first vertical offset is provided between four upward facing corner surfaces (100) and four upward facing edge surfaces (110) and wherein a second vertical offset is provided between the four upward facing edge surfaces (110) and one upward facing center surface (120), resulting in gaps between at least some of the upward facing surfaces (100;110;120) of the temperature equalizing plate (1) and corresponding wells of the thereon arranged microplate.
The invention relates to a method of determining fluid path connectivity in a fluidic system comprising a fluidic device (210) having at least one channel (246, 248, 250) that forms at least part of a fluid path (280). The method comprises steps of: - generating an acoustic signal at one end of the fluid path; - receiving the generated acoustic signal at an opposite end of the fluid path; - measuring an acoustic intensity of the received signal; and - correlating the measured acoustic intensity with a degree of fluid path connectivity.
F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
A method for determining physical parameters of a liquid to be aspirated and/or dispensed by a laboratory automation device comprises: picking up of a pipette with the laboratory automation device; lowering the pipette into a sample container with the laboratory automation device, the sample container containing the liquid; aspirating and dispensing air and liquid with the laboratory automation device in such a way, that a liquid level in the pipette solely rises in a first step and solely lowers in a second step, such that an interior surface of the pipette is wetted with liquid solely one time; and during aspirating and dispensing air and liquid, measuring a pressure curve in the pipette and determining the physical parameters from the pressure curve, the physical parameters comprising at least one of a surface tension, a wetting angle and a viscosity.
An incubation cassette is disclosed for reducing liquid evaporation from wells of a microplate. A frame has a central first opening surrounded by an inner wall having dimensions designed for the placement of a microplate therein and an outer wall which extends substantially parallel to the inner wall. The outer wall adjoins the inner wall via an intermediate bottom such that a liquid reservoir is formed thereby. The liquid reservoir surrounds the first central opening. At least a portion of the incubation cassette that forms the liquid reservoir has a transparent portion. A microplate reader has a housing and a transport support which can be pulled out of the housing. The transport support has a bearing surface for placement of a microplate having a plurality of wells or such an incubation cassette, and a controller adapted to control a method for reducing liquid evaporation from wells of the microplate.
A method for determining physical parameters of an unknown liquid to be aspirated and/or dispensed by a laboratory automation device comprises: determining physical parameters of a pipette, the physical parameters including geometric parameters of the pipette, which at least include a tip radius of an orifice of the pipette; aspirating and/or dispensing the unknown liquid with a pipette of the laboratory automation device and measuring a measured pressure curve in the pipette during aspirating and/or dispensing; determining the physical parameters of the unknown liquid by minimizing an objective function depending on a difference between a simulated pressure curve and the measured pressure curve, wherein the simulated pressure curve simulates a pressure in the pipette during aspirating and/or dispensing and is calculated based on a physical model of the laboratory automation device including the physical parameters of the pipette.
A method for classifying a specific pipetting procedure of a laboratory automation device comprises: determining a plurality of pressure curves of a plurality of pipetting procedures, which are equivalent to the specific pipetting procedure; determining a median curve from the plurality of pressure curves, wherein for each time point of the median curve, a median value of the values of the plurality of pressure curves at this time point is calculated; determining a median curve range containing the median curve; controlling the laboratory automation device to perform the specific pipetting procedure and measuring a specific pressure curve during the specific pipetting procedure; determining a deviation value of the specific pressure curve with respect to the median curve range, wherein the deviation value is indicative of the specific pressure curve leaving the median range; and classifying the specific pipetting procedure as erroneous, when the deviation value is greater than a threshold.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Robots, namely, automatic apparatus for collecting,
distributing or positioning objects and solid, liquid or
gaseous substances. Scientific apparatus and instruments, namely, robots for
collecting, distributing, transporting or positioning of
objects and solid, liquid and gaseous substances; Scientific
apparatus and instruments, namely, pipetting devices and
sampling devices, dispensers and dosing apparatus. Analytical apparatus and instruments for clinical diagnostic
use and for veterinary use, including pipetting devices and
sampling devices and dispensers.
37.
METHOD FOR CLOSING INCOMPLETE AREA OF INTEREST MARKINGS AND FOR FACILITATING TISSUE TREATMENT
Some embodiments are directed to completing incomplete area of interest markings. An area of interest marking indicates an area of interest on an image of a tissue section. The method may include detecting in the image endpoints of the one or more contours, and drawing in the image a segment connecting the matching endpoints in a selected pair.
Some embodiments are directed to planning treatment of an area of interest on a tissue section with a motorized treatment tip. The planning may include computing for each pixel in the area of interest a distance to the nearest pixel in the tissue section outside the area of interest or in the background, and selecting a position for a treatment area from the result of the distance transform.
A storage device for storing one or more pipettor consumables contains a storage plate having an upper side and a lower side, and, on the upper side, a number of accommodation seats arranged in an array. Each accommodation seat is configured to receive a pipettor consumable in an upside-down orientation. The storage device has one or more positioning elements for positioning the storage device in relation to a carrier, and/or one or more stacking elements for stacking the storage device with another storage device.
The present invention resides in a multichannel head of a pipetting device for aspirating and dispensing liquid via a plurality of pipetting tips. The multichannel head comprises a connector block (110) having an array of m*n connectors (120), whereby each connector comprises an internal passageway (125) that is fluidically connectable to a pipetting tip, and further includes a plunger block having a corresponding array of m*n channels. Each channel accommodates a plunger and has an opening that is fluidically connected to the internal passageway (125) of a corresponding connector. The multichannel head further comprises a sealing mat (150) arranged between the connector block (110) and the plunger block, wherein the sealing mat comprises a corresponding array of m*n annular sealing elements for providing an airtight seal of the fluidic connection between the internal passageway of each connector and each opening of the corresponding plunger channel. The annular sealing elements are interconnected by a lattice of linkages that extend in lateral direction and in longitudinal direction, such that a cut-out region is formed between two opposing lateral linkages and two opposing longitudinal linkages. The sealing mat (150) is arranged on a receiving surface (116), which is provided with protrusions (117) that are shaped to pass through the cut-out regions of the sealing mat.
A cartridge for use in an electrowetting sample processing system, the cartridge having one or more inlet ports for introducing an input liquid into an internal gap of the cartridge, which has at least one hydrophobic surface for enabling an electrowetting induced movement of multiple microfluidic droplets separated from the input liquid. The cartridge further has at least one outlet port that is operably connected to the inlet port for providing a liquid flow through the cartridge, if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.
A method for minimizing the dead volume (Vd) in a vial (10) presenting a liquid (L) for aspiration is provided. The method comprises, after determining that the liquid volume (Vi) indicated to be available in the vial (10) is not sufficient for a further aspiration step, moving downward in direction towards the bottom of the vial (10) by means of a pipetting arm (20) presenting a pipetting tip (21) and along the z-axis of the pipetting arm (20) until the pipetting arm (20) comes to a stop in a first stop position (S1z). Then, the actual available liquid volume (Va) is calculated based i.a. on said first stop position (S1z). In case the calculated actual available liquid volume (Va) is sufficient, a further aspiration step can be executed. Furthermore, a liquid handling system for minimizing dead volume (Vd), a computer-implemented method for controlling a pipetting arm (20) of such a liquid handling system, and the use of a hysteresis determination method for minimizing dead volume (Vd) are provided.
09 - Scientific and electric apparatus and instruments
Goods & Services
Robots, namely, automatic apparatus for collecting, distributing or positioning objects and solid, liquid or gaseous substances Scientific apparatus and instruments, namely, robots for collecting, distributing, transporting or positioning of objects and solid, liquid and gaseous substances; scientific apparatus and instruments, namely, pipetting devices and sampling devices, dispensers and dosing apparatus
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Robots, namely, automatic apparatus for collecting, distributing or positioning objects and solid, liquid or gaseous substances Scientific apparatus and instruments, namely, robots for collecting, distributing, transporting or positioning of objects and solid, liquid and gaseous substances; scientific apparatus and instruments, namely, pipetting devices and sampling devices, dispensers and dosing apparatus Analytical apparatus and instruments for clinical diagnostic use and for veterinary use, namely, pipetting devices and sampling devices and dispensers
09 - Scientific and electric apparatus and instruments
Goods & Services
Robots, namely, automatic apparatus for collecting,
distributing, transporting, positioning objects and solid,
liquid and gaseous substances. Scientific apparatus and instruments, namely, robots for
collecting, distributing, transporting, positioning objects
and solid, liquid and gaseous substances; scientific
apparatus and instruments, namely, pipetting devices and
sample collection devices, dispensers and dosing apparatus.
09 - Scientific and electric apparatus and instruments
Goods & Services
Robots, namely automatic machines for collecting,
distributing, transporting or positioning objects and solid,
liquid or gaseous substances. Scientific apparatus and instruments, namely robots for
collecting, distributing, transporting or positioning
objects and solid, liquid or gaseous substances; Scientific
apparatus and instruments, namely pipetting and sampling
devices, dispensers and dosing devices.
48.
METHOD OF OPERATING A PIPETTING SYSTEM, A PIPETTING SYSTEM, A TOOL, AND A COMPUTER-IMPLEMENTED METHOD
A method is described of operating a pipetting system (10) that has a worktable (12), at least one manipulator arm (18), and first and second Z-rods (20′,20″) arranged on the at least one manipulator arm (18). The method involves receiving by the second Z-rod (20″) a tool (24) via an adapter attached to the second Z-rod (20″), wherein the tool (24) has a central axis and a working area, the working area being defined by a circle which center is located on the central axis of the tool (24) and which radius being a distance between the central axis and a largest extension of an outline of the tool (24) in a projection.
A method for aspirating a first liquid medium from a sample container with a laboratory automation device, wherein the first liquid medium is above a second liquid medium, which has a higher density and/or viscosity as the first liquid medium comprises: detecting a surface position of a surface of the first liquid medium; calculating an estimated interface position of an interface between the first liquid medium and the second liquid medium from the surface position and calculating a safety position between the surface position and the estimated interface position by adding a safety offset to the estimated interface position; and lowering a pipette of the laboratory automation device into the sample container and aspirating the first liquid medium from the sample container with the pipette by generating an underpressure in the pipette until a pipette tip of the pipette reaches the safety position.
A method for determining states of a laboratory automation device includes: receiving a log file from the laboratory automation device, the log file including entries of events that occurred during a procedure performed by the laboratory automation device, wherein the events have been created by components of the laboratory automation device and each entry includes at least an event time and an event type; providing a state machine of the laboratory automation device, the state machine encoding states of the laboratory automation device and transitions between the states, wherein each transition is starting at a state and points to another state and wherein each transition is associated with an entry scheme in the log file, the entry scheme including at least an event type; setting a current state of the laboratory automation device to a beginning state; moving through the entries of the log file along increasing event time and associating the entries with the current state; during the moving, when an entry scheme associated with a transition starting at the current state is identified in the log file, changing the current state to the state to which the transition (60) is pointing.
A method for generating a control program for a laboratory automation device includes receiving configuration data of the laboratory automation device, generating a three-dimensional model of the components of the laboratory automation device from the configuration data, the three-dimensional model additionally including a virtual pipette; displaying the three-dimensional model with a virtual reality headset; receiving movement data of a motion sensing controller controlled by a user wearing the virtual reality headset, the movement data indicating a three-dimensional movement of the motion sensing controller in space; determining a movement of the virtual pipette in the three-dimensional model from the movement data and updating the three-dimensional model according to the movement of the virtual pipette; and generating a control program for the laboratory automation device from the movement data.
G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
A rotary valve comprises a stator member with a stator face, the stator member having at least two stator channels for conducting a fluid and opening into the stator face; a rotor member with a rotor face facing and in contact with the stator face, the rotor member having a rotor channel in the rotor face, wherein the rotor member is rotatable with respect to the stator member about a rotation axis, such that in a conducting position, the rotor channel interconnects the at least two stator channels to be in fluid communication; and a rotary encoder assembly adapted for determining a rotary position of the rotor member, the rotary encoder assembly comprising an encoder member and an encoder module, which is adapted to sense a rotary position of the encoder member. The encoder member is rigidly connected to the rotor member and surrounds the rotor member.
F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
F16K 11/08 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only taps or cocks
F16K 31/04 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic using a motor
A pipette tip extension attachable to a pipette tip with the pipette tip extension having a proximal end, a distal end, and exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall having an outer side and inner side and forming at the proximal end a reception aperture for inserting a pipette tip, and at a distal end a dispense aperture. An inner cavity is enclosed by the inner side of the exterior wall and one or more distance elements connected to the inner side of the exterior wall. The distance element(s) being configured to position a pipette tip within the inner cavity and to establish fluid uptake area adjacent the inner side of the exterior wall with the fluid uptake area extending from the dispense aperture towards the reception aperture and being in fluid connection with the surrounding atmosphere at the reception aperture.
A robotic sample handling system (100) may be provided for performing sample handling tasks in a laboratory environment. The system may comprise at least one robotic arm (140), (142) which is controllable to be positioned in a plane parallel to a work area and along a Z-axis perpendicular to the work area, and a controller (180) configured to control the robotic arm to position and operate the robotic arm as part of a sample handling task. The work area may comprise a module (204) for use with one or more of the samples, wherein the module comprises a mechanism which is actuatable by downward force, and wherein the controller is configured to control the robotic arm to actuate the mechanism by pushing downward in Z-direction. For example, the module may be a stand (204) for a sample container which comprise a push-push mechanism which may be operated by the robotic arm to bring the sample in the sample container in a vicinity of an effector, such as a magnet or a heat source.
A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge contains an internal gap with at least one hydrophobic surface for enabling an electrowetting induced movement of a microfluidic droplet that has magnetic beads and further has a bead accumulation zone, into which the microfluidic droplet is transferable by electrowetting force and the magnetic beads are exposable to a magnetic force of a bead manipulation magnet. The internal gap has a bead extraction opening adjacent to the bead accumulation zone. The bead extraction opening provides a passage from the gap to an exterior space of the cartridge and is configured to removably receive the bead manipulation magnet for enabling an extraction of the magnetic beads from the microfluidic droplet by a removal of the bead manipulation magnet.
The invention relates to a multi-channel head (100) of a liquid handling apparatus for aspirating and dispensing a metered amount of liquid, comprising:
an array of connectors (130) for picking up an array of disposable tips, whereby a peripheral end of each connector is provided with an elastomeric seal (140);
an alignment plate (150) that is moveable in a z-direction and has a plurality of openings through which the connectors (130) extend,
a linear displacement mechanism (170b, 175), driven by a motor (180), for moving the alignment plate (150) in z-direction relative to the connectors, and a controller for controlling the motor.
The multi-channel head is configured to attach the array of disposable tips in a pick-up action, in which the multi-channel head (100) is lowered relative to the disposable tips so as to insert each connector into an internal passageway of a corresponding disposable tip by an amount sufficient to bring an upper collar of the disposable tips into contact with an underside (150s) of the alignment plate. This insertion deforms the elastomeric seal against the tip internal passageway so as to form a sealing contact therewith. The controller of the multi-channel head (100) is programmed such that once the pick-up action is complete, an alignment action is performed in which the alignment plate (150) is moved relative to connectors (130) by an amount sufficient to close any gap between the underside (150s) of the alignment plate and the upper surface of the tip collars that arises due to e.g. relaxation of the deformed seals (140).
A laboratory automation device comprises a workspace with liquid containers and a pipetting arm for moving liquids between the liquid containers; a housing enclosing the workspace; a door of the housing for accessing the workspace, wherein the door comprises a transparent display for displaying information and for allowing a person to view into the workspace and a tracking sensor for tracking an eye position of the person. The laboratory automation device is adapted for determining the eye position of the person from sensor data acquired with the tracking sensor; and for displaying information for a notification area in the workspace on the transparent display, such that the information is displayed from a perspective of the person in front of the notification area.
A cooling module (106' ) for receiving a plurality of containers (116), said cooling module (106' ) comprising a housing (122) including at least one opening (124), a cooling block arranged into the housing (122), at least one compartment for receiving the containers (116) via the opening (124), and at least one cover ( 108, 108 ', 108 ' ' ) for covering the opening (124) against the exterior.
Some embodiments are directed to a method for detaching tissue from a tissue section on a tissue slide. The method may include applying a 3D printed mask on top of the tissue section, the mask comprising barriers that define a cavity surrounding an area of interest on the tissue section, the cavity being open at a side facing the area of interest on the tissue section, dispensing a detaching liquid to the cavity, and allowing the detaching liquid to detach tissue at the area of interest, and aspirating the detaching liquid with the detached tissue from the cavity, and forwarding the liquid for further processing.
A method of measuring the alignment of one or more pipetting tips in an automated pipetting system where the one or more pipetting tips are mounted on one or more adapters of a pipetting head approximately perpendicular to the pipetting head mounting surface is disclosed. The orifices at the end of the one or more pipetting tips are mapped with an image capture device having a sensor placed in face and distant of the orifices. The method sends the acquired data from mapping the orifices of the one or more pipetting tips to the data processor, generating an image of the orifices of the one or more pipetting tips, determining the center positions of orifices, and delivering alignment information for the one or more pipetting tips.
A method for detecting contact of a pipette tip with a surface of a liquid in a pipetting device is disclosed. The method consists of moving the pipette tip in the direction of the surface of the liquid thereby measuring an absolute capacitance between the pipette tip and a reference potential and generating a sampled output signal. A predicted momentary sample value of the output signal is generated based on a plurality of past sample values of the output signal. A contact signal indicative of the pipette tip being in contact with the surface of the liquid is generated based on comparing a momentary sample value of the output signal with the predicted momentary sample value of the output signal. A corresponding pipetting device capable of performing the method as a laboratory system, in particular an automated liquid processing system, with one or more such pipetting devices are proposed.
09 - Scientific and electric apparatus and instruments
Goods & Services
Robot, namely Automated machines for the uptake, discharge, conveying or positioning of objects or solid, liquid and gaseous substances. Scientific apparatus and instruments, namely Robots for the uptake, discharge, conveying or positioning of objects and solid, liquid or gaseous substances; Scientific apparatus and instruments, namely Pipetting and sampling devices, dispensers and dosage dispensers.
09 - Scientific and electric apparatus and instruments
Goods & Services
Robot, namely Automated machines for the uptake, discharge, conveying or positioning of objects or solid, liquid and gaseous substances. Scientific apparatus and instruments, namely Robots for the uptake, discharge, conveying or positioning of objects and solid, liquid or gaseous substances; Scientific apparatus and instruments, namely Pipetting and sampling devices, dispensers and dosage dispensers.
65.
TRACKING OF LYSING AT A LOCATION ON A TISSUE SECTION
Some embodiments are directed to a method for tracking lysis progress in an automated lysing device. For example, the lysing device may be configured to execute multiple iterations of lysing at a defined location on the tissue section and imaging the defined location on the tissue section using a camera. From the images a lysing parameter may be determined to improve lysing.
Some embodiments are directed to image registration. A rotation angle is determined and subsequently a translation vector. The rotation angle and translation vector together defining an alignment transformation between a first image and a second image. Determining the rotation angle may include iterating over multiple potential rotation angles, and determining alignment.
A dark-field imaging system comprising a platform for holding biologic tissue or cells, constituting a plane forming two half-spaces. The dark-field imaging system further comprises a light source, which generates an incident light targeting the biologic tissue or cells, and a camera to detect diffuse reflection off the biologic tissue or cells. The light source is placed at a first angle (a) relative to the plane, and the camera is placed at a second angle (β) relative to the plane wherein the light source, the camera, and the biologic tissue or cells are arranged in the same one of the two half-spaces formed by the plane. The incident light that is not reflected by the biologic tissue or cells reaches the platform, which comprises a specularly reflecting material that reflects the incident light at least in part by specular reflection. Use of such a dark-field imaging system in an application for interacting with areas of interest of biological samples, where the dark-field imaging system takes high-contrast images of biologic tissue or cells in an automated laboratory system, and an automated laboratory system comprising such a dark-field imaging system.
An incubation cassette for reducing liquid evaporation from wells of a microplate with a frame for receiving a microplate with wells, the frame having a central first opening surrounded by an inner wall, the dimensions are designed for inserting a microplate, and the frame having an outer wall that runs essentially parallel to the inner wall and which is attached to the inner wall connects so that a liquid reservoir surrounding the first central opening for receiving a liquid is formed by the two walls and the intermediate base is disclosed. The incubation cassette also includes a float provided in the liquid reservoir that can be brought into fluid contact with the liquid held in the liquid reservoir in such a way that the float is in relation to the liquid level of the liquid in the liquid reservoir absorbed liquid experiences buoyancy.
C12M 1/32 - Inoculator or sampler multiple field or continuous type
C12M 1/00 - Apparatus for enzymology or microbiology
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
G01F 23/68 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by floats of the free float type using electrically actuated indicating means
37 - Construction and mining; installation and repair services
40 - Treatment of materials; recycling, air and water treatment,
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Installation, assembly, repair, maintenance, overhaul,
inspection and monitoring of robots, scientific, optical,
analytical, measuring, dosing, checking and control
apparatus and instruments, pipetting and sampling devices,
dispensers, pumps and dosing apparatus for laboratory use,
and imaging devices; providing information relating to all
the aforementioned services. Custom manufacturing to the order and requirements of a
customer with regard to scientific devices and instruments
or with regard to modules of scientific devices and
instruments; Custom manufacturing to the order and
requirements of a customer with regard to medical and
veterinary devices and instruments or with regard to modules
of medical and veterinary devices and instruments; custom
assembly to the order and requirements of a customer with
regard to scientific devices and instruments or with regard
to modules of scientific devices and instruments; custom
assembly to the order and requirements of a customer with
regard to medical and veterinary devices and instruments or
with regard to modules of medical and veterinary devices and
instruments; processing and treatment of plastics; molding
of plastics. Educational and training services, including provision of
data and materials for educational purposes for users of
laboratory apparatus; Providing training and educational
materials online. Planning and design of automated laboratory systems; Custom
development of laboratory automation equipment and analysis
instruments; development of computer software; technological
services with regard to product life cycle management for
technical products, including development, production,
product improvements, decommissioning and disposal;
providing temporary use of non-downloadable software for
controlling and monitoring apparatus and instruments for
laboratories, for controlling and monitoring medical
apparatus and for the analysis of measurement results;
providing temporary use of non-downloadable or
internet-based software for use in the automation of
laboratories; hosting internet platforms [software]; hosting
internet portals; hosting computerized data, files,
applications and information; providing computer programs in
data networks; providing software [Software as a service,
SaaS]; platform as a Service [PaaS]; installation, repair
and maintenance of software; backup of electronic data;
analysis and evaluation of products and services with regard
to possible future uses.
A pipette includes an end section, a first section, a second section and a third section aligned along a central axis of the pipette tip. The end section comprises an orifice for aspirating and dispensing a fluid. A first kink is formed in an inner surface of the pipette tip between the first section and the second section, such that an angle between the inner surface of the first section and the central axis is smaller than an angle between the inner surface of the second section and the central axis. A second kink is formed in the inner surface of the pipette tip between the second section and the third section, such that the angle between the inner surface of the second section and the central axis is smaller than an angle between the inner surface of the third section and the central axis.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Biochemical reagents for scientific or research purposes, in
particular for use related to nucleic acid analysis, protein
analysis, protein profiling and analysis of cell components. Biochemical reagents for clinical medical diagnostic use and
use in veterinary medicine, in particular for use related to
nucleic acid analysis, protein analysis, protein profiling
and analysis of cell components. Scientific apparatus and instruments, namely, devices for
pipetting, imaging, extraction from tissue samples and
purification of nucleic acids and proteins; Pipetting tip
extensions for use in laboratory apparatus; software for
image analysis; application software; software for
controlling scientific apparatus and instruments. Analytical apparatus and instruments for clinical diagnostic
use and veterinary diagnostic use, namely, devices for
pipetting, imaging, extraction from tissue samples and
purification of nucleic acids and proteins.
72.
Cartridge, electrowetting sample processing system and droplet formation
A cartridge for use in an electrowetting sample processing system, the cartridge having at least one inlet port for introducing an input liquid in an internal gap of the cartridge, wherein the gap has at least one hydrophobic surface and is configured to provide an electrowetting induced movement of a microfluidic droplet of input liquid, wherein the input liquid has a carrier liquid and a processing liquid and the gap has a capture zone that is configured to capture at least a part of the processing liquid as a microfluidic droplet by use of electrowetting force and the gap further has a transfer zone that is configured to provide a passage for the carrier liquid next to the microfluidic droplet, while processing liquid is captured in the capture zone.
A cover for a fluid container having an essentially plane cover plate for closing at least one opening of at least one fluid container and at least two ports, and each port has a through channel extending through the entire thickness of the cover plate and a fluid impermeable first membrane is arranged over the entire cross section of the through channel of the first port and an at least gas permeable second membrane is arranged over the entire cross section of the through channel of the second port is disclosed.
A rotary valve includes a stator member with a planar stator face, the stator member having a plurality of stator channels for conducting a fluid; and a rotor member with a planar rotor face facing and in contact with the stator face, the rotor member having a rotor channel; wherein the rotor member is rotatable with respect to the stator member about a rotation axis, such that in a conducting position, the rotor channel interconnects two of the stator channels and the two stator channels are in fluid communication; wherein at least one of the stator channels has a transverse channel section opening into the stator face and running transversely with respect to the rotation axis; wherein the rotor channel has a bottom, which at an intersection end of the rotor channel is inclined with respect to the rotation axis, such that the rotor channel elongates an inner surface of the stator channel, when the rotor member is in the conducting position.
F16K 11/074 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
A method is disclosed for controlling at least one of aspirating and of dispensing a liquid dose or of producing a liquid dose in a pipette or in receptacle, the method having the steps of first loading a first pipette with a first working medium at a first pressure having a first sign with respect to a reference pressure, thereby dispensing the liquid dose into the receptacle or aspirating the liquid dose into the first pipette, second loading a second pipette with a second working medium at a second pressure having a second sign with respect to the reference pressure, thereby dispensing the liquid dose into the receptacle or aspirating the liquid dose into the second pipette, discharging a pressure in the first working medium through a controlled valve arrangement to the reference pressure between first and second loadings. A pipetting device is also disclosed.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Biochemical reagents for scientific or research purposes, in particular for use related to nucleic acid analysis, protein analysis, protein profiling and analysis of cell components Biochemical reagents for clinical medical diagnostic use and use in veterinary medicine, in particular for use related to nucleic acid analysis, protein analysis, protein profiling and analysis of cell components Scientific apparatus and instruments, namely, devices for laboratory pipetting, non-medical imaging devices for imaging of cells, cell colonies, biological tissues, electrophoresis gels, protein arrays and nucleic acid arrays, laboratory devices for extraction from tissue samples, and laboratory apparatus for purification of nucleic acids and proteins; Disposable materials for use in laboratory apparatus, namely, Pipette tips and pipetting tip extensions for use in laboratory apparatus; Downloadable or recorded software for image analysis; Downloadable or recorded application workflow programming software; Downloadable or recorded computer software for controlling scientific apparatus and instruments Medical and veterinary analytical apparatus and instruments for clinical diagnostic use and veterinary diagnostic use, namely, medical and veterinary devices for pipetting, imaging, extraction from tissue samples and purification of nucleic acids and proteins; all the aforementioned products for clinical medical diagnostic and veterinary diagnostic purposes Providing online non-downloadable computer software for image analysis; Providing online non-downloadable application programming interface software; Providing online non-downloadable computer software for controlling scientific apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
37 - Construction and mining; installation and repair services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Custom manufacturing to the order and requirements of a customer with regard to scientific devices and instruments or with regard to modules of scientific devices and instruments; Custom manufacturing to the order and requirements of a customer with regard to medical and veterinary devices and instruments or with regard to modules of medical and veterinary devices and instruments; Custom assembly to the order and requirements of a customer with regard to scientific devices and instruments or with regard to modules of scientific devices and instruments; Custom assembly to the order and requirements of a customer with regard to medical and veterinary devices and instruments or with regard to modules of medical and veterinary devices and instruments; Processing and treatment of plastics; Molding of plastics Installation, assembly, repair, maintenance, and overhaul of robots, scientific, optical, analytical, measuring, dosing, checking and control apparatus and instruments, pipetting and sampling devices, dispensers, pumps and dosing apparatus for laboratory use, and imaging devices; providing information relating to all the aforementioned services Educational and training services, namely, conducting classes, seminars and workshops in the field of laboratory apparatus and the provision of data and materials in connection therewith for educational purposes for users of laboratory apparatus; providing online education and trainings, namely, conducting classes, seminars and workshops in the field of laboratory apparatus Planning and design of laboratory automation systems; order development of laboratory automation equipment and analysis instruments; development of computer software; Technological advisory services with regard to product life cycle management for technical products, namely, advisory services for the development, production, product improvements, decommissioning and disposal of technical products; providing temporary use of non-downloadable software for controlling and monitoring apparatus and instruments for laboratories, for controlling and monitoring medical apparatus and for the analysis of measurement results; providing temporary use of non-downloadable or internet-based software for use in the automation of laboratories; providing internet platforms, namely, providing on-line, non-downloadable, internet-based software for use in the automation of laboratories, and for use in controlling and monitoring apparatus and instruments for laboratories, in controlling and monitoring medical apparatus and in the analysis of measurement results; hosting internet portals for others; hosting computerized data, files, applications and information of others; providing computer programs in data networks, namely, on-line non-downloadable software programs for use in the automation of laboratories, and for use in controlling and monitoring apparatus and instruments for laboratories, in controlling and monitoring medical apparatus and in the analysis of measurement results; providing software as a service (SaaS) featuring software for use in the automation of laboratories, and for use in controlling and monitoring apparatus and instruments for laboratories, in controlling and monitoring medical apparatus and in the analysis of measurement results; Platform as a Service (PaaS) featuring computer software platforms for use in the automation of laboratories, and for use in controlling and monitoring apparatus and instruments for laboratories, in controlling and monitoring medical apparatus and in the analysis of measurement results; installation, repair and maintenance of software; backup of electronic data; analysis and evaluation of products and services with regard to possible future uses; Remote monitoring of the functioning and use of technology in the nature of robots, scientific, optical, analytical, measuring, dosing, checking and control apparatus and instruments, pipetting and sampling devices, dispensers, pumps and dosing apparatus for laboratory use, and imaging devices; Providing information in the field of remote monitoring of the functioning and use of technology in the nature of robots, scientific, optical, analytical, measuring, dosing, checking and control apparatus and instruments, pipetting and sampling devices, dispensers, pumps and dosing apparatus for laboratory use, and imaging devices
78.
Displacement device and method for displacing fluid volumes
A displacement device for displacing a displacement volume is disclosed. The device has a first fluid space and a second fluid space. A first piston is arranged in a movable manner within the first fluid space. The first fluid space is connectable to a pipetting device. The first piston is actuatable by an actuation volume of air or of liquid provided by the pipetting device. A second piston is arranged in a movable manner within the second fluid space. The second piston is constructed to displace a displacement volume of a fluid located within the second fluid space when the second piston is actuated. The second piston is actuated in dependence on the first piston that is actuated by the actuation volume. The actuation volume is different from the displacement volume, and a pipetting system has a displacement device and a method of displacing a displacement volume.
A method for minimizing the dead volume (Vd) in a vial (10) presenting a liquid (L) for aspiration is provided. The method comprises, after determining that the liquid volume (Vi) indicated to be available in the vial (10) is not sufficient for a further aspiration step, moving downward in direction towards the bottom of the vial (10) by means of a pipetting arm (20) presenting a pipetting tip (21) and along the z-axis of the pipetting arm (20) until the pipetting arm (20) comes to a stop in a first stop position (Slz). Then, the actual available liquid volume (Va) is calculated based i.a. on said first stop position (Slz). In case the calculated actual available liquid volume (Va) is sufficient, a further aspiration step can be executed. Furthermore, a liquid handling system for minimizing dead volume (Vd), a computer-implemented method for controlling a pipetting arm (20) of such a liquid handling system, and the use of a hysteresis determination method for minimizing dead volume (Vd) are provided.
A door for a laboratory workstation is disclosed. The laboratory workstation has a horizontally extending work surface for providing a working area. The door is movable in relation to the work surface in a vertical direction perpendicular to the work surface between a safety position, in which the door closes the working area for manual access of a user, an access position in which the working area is open for manual access of a user, and a loading position.
A method for aspirating a first liquid medium of two liquid media of different density from a sample container comprises: lowering a pipette of the laboratory automation device into the sample container until a pipette tip of the pipette has passed a lowering distance from the surface of the first liquid medium in the sample container, wherein the lowering distance is chosen, such that the pipette tip passes at least an aspiration volume in the sample container; aspirating liquid from the sample container during the lowering of the pipette by generating an underpressure in the pipette, wherein the first liquid medium is aspirated, and after the interface and the pipette tip pass each other, the second liquid medium of the two liquid media is aspirated; measuring a pressure in the pipette during the lowering of the pipette and detecting a position of the interface, when a slope of the pressure changes; when the lowering distance has been passed and no interface is detected, aspirating the aspiration volume from the first liquid medium and dispensing the aspiration volume of the first liquid medium into a further sample container.
A receiving frame for a support plate for pipette tips that is formed from two opposing longitudinal walls and two opposing transverse walls, each has an upper side and a lower side and laterally enclose an interior space is disclosed. The upper sides of the longitudinal walls and transverse walls together form a circumferential support surface on which a support plate for pipette tips can be reversibly placed. The receiving frame has a footprint on the lower side of the longitudinal walls and the transverse walls.
Arrangements of a gripper finger and a clamp for use in an automated parallel gripper are provided. The arrangements will include first and second gripper fingers that are moveable in a direction of translation (y), whereby the clamp is connected to the gripper finger at an underside thereof, so as to be rotational about a vertical axis of rotation. The clamp has a front face with a contact surface for engagement with a lateral edge of an item to be gripped and has a default orientation in which the front face is parallel to a lateral direction (x) that is perpendicular to the direction of translation (y) and to the vertical rotation axis. The arrangements are additionally provided with a self-alignment feature which includes first and second biasing mechanisms arranged at either side of the rotation axis in lateral direction (x). Each biasing mechanism has a first part connected to the finger and a second part connected to the clamp and is configured to exert a centering force that urges the first and second parts of each biasing mechanism into alignment with each other. When the clamp is in the default orientation, each biasing mechanism is preloaded to exert an equal moment load on the clamp in the direction of translation (y).
A robotic arm of an automated pipetting system has a pipetting tip adapter and a slide switch to detect the presence of pipetting tips on the pipetting tip adapter is disclosed. The slide switch has first support member and second support member configured to slide relative to one another between first and second positions along a movement axis, an electrically conducting contact pad arranged on the first support member, an electrically conducting terminal physically attached to second support member in physical contact with the contact pad when support members are in first position, where the terminal is a first resilient wiping member expanding along the movement axis, first wiping member is not in physical contact with the contact pad when support members are in second position, and an electric current can flow between first wiping member and the contact pad when support members are in first position.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
H01H 1/40 - Contact mounted so that its contact-making surface is flush with adjoining insulation
H01H 3/16 - Operating parts, i.e. for operating driving mechanism by a mechanical force external to the switch adapted for actuation at a limit or other predetermined position in the path of a body, the relative movement of switch and body being primarily for a purpose other than the actuation of the switch, e.g. for a door switch, a limit switch, a floor-levelling switch of a lift
A rotary valve (10) comprises a stator member (36) with a stator face (54), the stator member (36) having at least two stator channels (46, 48) for conducting a fluid and opening into the stator face (54); a rotor member (24) with a rotor face (52) facing and in contact with the stator face (54), the rotor member (24) having a rotor channel (50) in the rotor face (52), wherein the rotor member (24) is rotatable with respect to the stator member (36) about a rotation axis (A), such that in a conducting position, the rotor channel (50) interconnects the at least two stator channels (46, 48) to be in fluid communication; and a rotary encoder assembly (33) adapted for determining a rotary position of the rotor member (24), the rotary encoder assembly (33) comprising an encoder member (34) and an encoder module (35), which is adapted to sense a rotary position of the encoder member (34). The encoder member (34) is rigidly connected to the rotor member (24) and surrounds the rotor member (24).
F16K 11/072 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members
F16K 31/04 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic using a motor
F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
A robotic liquid handling system may be provided comprising a robotic arm and a controller configured to control the robotic arm to position and operate the robotic arm in a workspace of the robotic liquid handling system. The controller may be configured to, as part of a liquid handling task, control the robotic arm to open a reagent reservoir, wherein the reagent reservoir has an opening which is sealed by a foil. The controller may be configured to control the robotic arm to open the foil by controlling the robotic arm to, using a cutting tip (260), cut at least two flaps in the foil, and using a blunt protrusion, push the at least two flaps downwards into the reagent reservoir to clear at least part of the opening of the reagent reservoir. Further aspects of the invention relate to a computer-implemented method for controlling a robotic arm and to an opening tool (200) comprising the cutting tip and the blunt protrusion.
A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge has a liquid input port for introducing an input liquid into an internal gap of the cartridge, the input liquid providing for at least one droplet, directly or via a liquid separation process within the internal gap, and the internal gap having at least one hydrophobic surface, at least one processing zone for processing samples located in the processing zone, and a delivery zone for delivering the at least one droplet from the liquid input port to the at least one processing zone. The delivery zone is configured to provide a repeating pattern of interacting electrowetting force for simultaneously transporting the at least one droplet within the delivery zone.
A multichannel pipetting plate comprises a plurality of connectors arranged in a lattice; wherein each connector is fluidically connectable to a pipetting tip; wherein each connector comprises an interface at which a friction contact between the connector and a foot of the pipetting tip is established; wherein the interfaces of the connectors are arranged in different planes, such that, at least at a border region of the pipetting plate, along each row and along each column of the lattice, at least three consecutive interfaces are arranged in at least two different planes.
A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension also has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, and one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.
B03C 1/01 - Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
B03C 1/32 - Magnetic separation acting on the medium containing the substance being separated, e.g. magneto-gravimetric-, magnetohydrostatic-, or magnetohydrodynamic separation
A rotary valve (10) comprises a stator member (36) with a planar stator face, the stator member (36) having a plurality of stator channels (46, 48) for conducting a fluid; and a rotor member (24) with a planar rotor face (52) facing and in contact with the stator face, the rotor member (24) having a rotor channel (50); wherein the rotor member (24) is rotatable with respect to the stator member (36) about a rotation axis (A), such that in a conducting position, the rotor channel (50) interconnects two of the stator channels (46, 48) and the two stator channels (46, 48) are in fluid communication; wherein at least one of the stator channels (48) has a transverse channel section (74) opening into the stator face (54) and running transversely with respect to the rotation axis (A); wherein the rotor channel (50) has a bottom (64), which at an intersection end (62) of the rotor channel (50) is inclined with respect to the rotation axis (A), such that the rotor channel (50) elongates an inner surface of the stator channel (48), when the rotor member (24) is in the conducting position.
F16K 3/08 - Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with flat sealing facesPackings therefor with pivoted closure members in the form of closure plates arranged between supply and discharge passages with circular closure plates rotatable around their centres
F16K 11/074 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
A method of treating an isolated area of a sample with a liquid is disclosed. The method has the steps of generating an isolated area of a sample by a first fluid reservoir where the first fluid reservoir enclosing a distal end of a second fluid reservoir and the isolated area of the sample being sealed towards the remaining area of the sample, bringing the isolated area of the sample into fluid connection with the second fluid reservoir, dispensing a fluid from the second fluid reservoir into the first fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a first direction, and aspirating the fluid from the first fluid reservoir into the second fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a second direction.
A method for classifying liquid handling procedures comprises includes receiving measurement data encoding a measurement curve of measurements over time during at least a part of a liquid handling procedure; inputting the measurement data into a neural network; and calculating at least one quality value for the liquid handling procedure with the neural network.
A pipette tip extension attachable to a pipette tip having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip, and at the distal end a dispense aperture. The pipette tip extension further has an inner cavity, a distance element connected to the inner side of the exterior wall, and a constriction element.
B03C 1/01 - Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
B03C 1/32 - Magnetic separation acting on the medium containing the substance being separated, e.g. magneto-gravimetric-, magnetohydrostatic-, or magnetohydrodynamic separation
A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension further has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity, and a coating for interacting with a fluid present in a fluid uptake area.
B03C 1/01 - Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
B03C 1/32 - Magnetic separation acting on the medium containing the substance being separated, e.g. magneto-gravimetric-, magnetohydrostatic-, or magnetohydrodynamic separation
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
95.
LABORATORY AUTOMATION DEVICE WITH TRANSPARENT DISPLAY IN DOOR
A laboratory automation device (10) comprises a workspace (26) with liquid containers (16) and a pipetting arm (20) for moving liquids (18) between the liquid containers (16); a housing (28) enclosing the workspace (26); a door (30) of the housing (28) for accessing the workspace (26), wherein the door (30) comprises a transparent display (32) for displaying information (34) and for allowing a person to view into the workspace (26); and a tracking sensor (36) for tracking an eye position (46) of the person (42). The laboratory automation device (10) is adapted for determining the eye position (46) of the person (42) from sensor data acquired with the tracking sensor (36); and for displaying information (34b) for a notification area (48) in the workspace (26) on the transparent display (32), such that the information (34b) is displayed from a perspective of the person (42) in front of the notification area (48).
A robotic sample handling system (100) may be provided for performing sample handling tasks in a laboratory environment. The system may comprise at least one robotic arm (140), (142) which is controllable to be positioned in a plane parallel to a work area and along a Z-axis perpendicular to the work area, and a controller (180) configured to control the robotic arm to position and operate the robotic arm as part of a sample handling task. The work area may comprise a module (204) for use with one or more of the samples, wherein the module comprises a mechanism which is actuatable by downward force, and wherein the controller is configured to control the robotic arm to actuate the mechanism by pushing downward in Z-direction. For example, the module may be a stand (204) for a sample container which comprise a push-push mechanism which may be operated by the robotic arm to bring the sample in the sample container in a vicinity of an effector, such as a magnet or a heat source.
A pipette tip extension having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and encloses an inner cavity which is delimited by the inner side of the exterior wall. The exterior wall forms at the proximal end a reception aperture. The pipette tip extension further has one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.
A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface and a control unit for manipulating liquid droplets by electrowetting, providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface, providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit, actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.
A centrifugal processing unit for directing the movement of substances within a sample processing cartridge has a rotor with an accommodation for receiving the sample processing cartridge, the accommodation only allowing a free pivoting motion of the cartridge about a respective pivot axis, wherein each pivot axis is orthogonal to the rotor axis and to a respective force vector of a centrifugal force, a rotor drive to create the centrifugal force, a blocking element, allowing the free pivoting motion of the cartridge in a release position and preventing the free pivoting motion in a blocking position, wherein the blocking element is arranged on the rotor spaced apart above the accommodation is disclosed.
A cartridge configured to control and manipulate liquids and to be positioned at a cartridge accommodation site of a digital microfluidics system is disclosed. The digital microfluidics system has a number or array of individual electrodes attached to a first substrate or PCB, a central control unit in operative contact with individual electrodes for controlling selection and for providing a number of individual electrodes that define a path of individual electrodes with voltage for manipulating liquid portions or liquid droplets by electrowetting, and a cartridge accommodation site that is configured for taking up the cartridge.
