The present invention relates to a novel AMPK-activating peptide and uses thereof. The novel peptide of the present invention exhibits excellent anti-aging, antioxidant, and anti-inflammatory effects, and can reduce wrinkles by promoting collagen synthesis. Accordingly, the peptide is highly applicable not only to a cosmetic composition and a food composition, but also to a pharmaceutical composition for treating/alleviating AMPK-related diseases.
C07K 5/097 - Tripeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp, e.g. thyroliberin, melanostatin
C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/107 - Tetrapeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
C07K 5/113 - Tetrapeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
3.
NOVEL PEPTIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MACULAR DEGENERATION COMPRISING SAME
The present invention provides: a novel peptide derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition comprising the novel peptide derivative or the pharmaceutically acceptable salt thereof as an active ingredient for the prevention or treatment of macular degeneration.
The present invention provides a pharmaceutical composition for preventing or treating a hand-foot syndrome or hand-foot skin reaction, comprising a specific peptide derivative or a mixture of specific peptide derivatives as an active ingredient.
The present invention relates to: a peptide that exhibits a similar effect to Botox by binding to SNAP -25 or VAMP to inhibit the formation of a snare complex; and a cosmetic composition comprising same.
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 5/09 - Tripeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
C07K 5/113 - Tetrapeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
C07K 5/113 - Tetrapeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
The present invention provides a specific peptide; and a cosmetic composition for inhibiting or alleviating excessive sebum secretion and a pharmaceutical composition for preventing, alleviating, or treating excessive sebum secretion, each comprising the peptide as an active ingredient. The peptide inhibits the interaction between FOXO4 and p53 and, as a result, significantly increases in the interaction between p53 and RNA Polymerase II (POLII), thereby inducing apoptosis of sebaceous cells.
C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/107 - Tetrapeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
The present invention provides a cosmetic composition for inhibiting or improving seborrhea and a pharmaceutical composition for preventing, improving or treating seborrhea, each composition comprising a specific peptide as an active ingredient. The peptide remarkably decreases the interaction between p53 and MDM2 and thus remarkably increases the interaction between p53 and RNA Polymerase II (POLII), thereby being able to induce expressions of the cytokines that cause apoptosis of sebocytes.
Provided is a method for preventing, ameliorating, or treating degenerative diseases caused by cellular senescence, preferably osteoarthritis or atherosclerosis, comprising a specific peptide as an active ingredient, where the peptide remarkably inhibits the interaction of p53 and FOXO4 (Forkhead box protein O4), thereby inhibiting the expression of a cellular senescence regulator.
KNU-INDUSTRY COOPERATION FOUNDATION (Republic of Korea)
Inventor
Hahn, Jang Hee
Kim, Min Seo
Abstract
The present invention relates to a peptide that can be used to alleviate skin troubles caused by fine dust and inhibits the activity of an aryl hydrocarbon receptor, and a cosmetic composition using the same.
C07K 5/113 - Tetrapeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
KNU-INDUSTRY COOPERATION FOUNDATION (Republic of Korea)
Inventor
Hahn, Jang Hee
Kim, Min Seo
Abstract
The present invention relates to peptides inhibiting androgen receptor activity, and a cosmetics composition using same that can be used to alleviate androgen-related diseases such as prostate cancer, skin diseases, alopecia, and the like.
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
A61Q 7/00 - Preparations for affecting hair growth
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
Goods & Services
Cosmetics; cosmetic preparations for skin care; body and beauty care cosmetics; cosmetics for spa; cosmetics for massage; cosmetic preparations for the hair and scalp; functional cosmetics; anti-wrinkle creams; skin whitening preparations; sun care preparations; lip balm; cleansers; make-up; multi-functional shampoo; body wash; perfumes; essential oils.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
Goods & Services
cosmetics; cosmetic preparations for skin care; body and beauty care cosmetics; cosmetics for spa in the nature of body mask cream and facial beauty masks; cosmetic massage creams; cosmetic preparations for the hair and scalp; functional cosmetics in the nature of cosmetic rouges, nail varnish for cosmetic purposes, and skin balsams; anti-wrinkle creams; skin whitening preparations; non-medicated sun care preparations; lip balm; skin cleansers; make-up; multi-functional hair shampoo; body wash; perfumes; essential oils; all of the foregoing containing peptides
15.
INSULIN A-CHAIN DERIVED PEPTIDE FRAGMENT AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETES OR DIABETIC WOUNDS, CONTAINING SAME
KNU-INDUSTRY COOPERATION FOUNDATION (Republic of Korea)
SUPADELIXIR INC. (Republic of Korea)
Inventor
Hahn, Jang-Hee
Kim, Chang-Gyum
Abstract
Provided in the present invention are an insulin A-chain derived peptide fragment and a pharmaceutical composition for preventing or treating diabetes or diabetic wounds, containing the same as an active ingredient. The peptide of the present invention induces endocytosis through insulin receptors, has activities of increasing glucose uptake of cells by translocating glucose transporters onto a cell membrane, and of increasing cell migration and proliferation. Therefore, the peptide of the present invention can be usefully applicable in the prevention or treatment of diabetes or diabetic wounds.
Provided is a peptide fragment derived from secreted frizzled protein 5 (Sfrp5), i.e., a peptide fragment selected from the group consisting of the peptides as set forth in SEQ ID NOs: 1 to 9 and a cosmetic composition for skin-whitening and/or inhibiting skin pigmentation comprising the same as an active ingredient. The peptide fragment inhibits melanin formation in melanocytes, thereby having an inhibitory activity against skin pigmentation. Further provided is a reagent for researching or analyzing the inhibition of Wnt signaling pathways comprising the peptide fragment.
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/11 - Tetrapeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
Provided is a peptide fragment derived from secreted frizzled protein 5 (Sfrp5), i.e., a peptide fragment selected from the group consisting of the peptides as set forth in SEQ ID NOs: 1 to 9 and a cosmetic composition for skin-whitening and/or inhibiting skin pigmentation comprising the same as an active ingredient. The peptide fragment inhibits melanin formation in melanocytes, thereby having an inhibitory activity against skin pigmentation. Further provided is a reagent for researching or analyzing the inhibition of Wnt signaling pathways comprising the peptide fragment.
A01N 61/00 - Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
A61K 31/00 - Medicinal preparations containing organic active ingredients
C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/11 - Tetrapeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
18.
Composition comprising peptide derived from adiponectin
Provided is a pharmaceutical or cosmetic composition comprising adiponectin-derived peptide fragments, i.e., the peptides of SEQ ID NOs: 1 to 6 as an active ingredient. The peptides facilitate skin regeneration and moisturization, inhibit skin wrinkle, and have inhibitory activities against allergy and inflammation as well as metastasis of cancer cells.
KNU-INDUSTRY COOPERATION FOUNDATION (Republic of Korea)
SUPADELIXIR INC. (Republic of Korea)
Inventor
Hahn, Jang-Hee
Lim, Dong-Young
Abstract
The present invention provides: a peptide fragment derived from secreted frizzled protein 5 (Sfrp5), that is, a peptide fragment selected from the group consisting of peptides composed of amino acid sequences of SEQ ID NOs: 1 to 9; and a cosmetic composition, containing the same as an active ingredient, for skin whitening and/or skin pigmentation suppression. The peptide fragment has an activity to suppress skin pigmentation by inhibiting melanogenesis in melanin cells. In addition, the present invention provides reagents for research or analysis, containing the peptide fragment to suppress Wnt signaling.
KNU-INDUSTRY COOPERATION FOUNDATION (Republic of Korea)
SUPADELIXIR INC. (Republic of Korea)
Inventor
Hahn, Jang-Hee
Ko, In-Young
Yoo, Yeon-Ho
Kim, Yu-Ri
Kim, Min-Seo
Abstract
Provided is a composition containing peptide fragments or small peptides derived from epidermal growth factor (EGF) for wound healing and inhibiting aging of the skin or formation of skin wrinkles. The peptides activate EGF receptors and have activities promoting keratinocyte proliferation and angiogenesis in the skin. Accordingly, the peptides can be utilized effectively in wound healing and inhibiting aging of the skin or formation of skin wrinkles.
Provided are small peptide fragments derived from microphthalmia-associated transcription factor (MITF) and a method for preventing or treating melanoma using the same as an active ingredient. Further provided is a method for skin-whitening and/or for inhibiting skin pigmentation, using the peptide fragments as an active ingredient.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
22.
Peptides having NF-κB inhibitory activity, or composition comprising same
Provided are small peptide fragments derived from the NF-κB p65 subunit and a pharmaceutical or cosmetic composition comprising the same. The peptides have a NF-κB inhibitory activity, through controlling the transcription-activation of NF-κB. The peptides inhibit the expressions of pro-inflammatory mediators, which are induced by NF-κB, and also inhibit the transmigration of leukocytes, thereby exhibiting an anti-inflammatory activity. Especially, the peptides have excellent inhibitory activities against dermatitis and skin aging. And also, the peptides inhibit base membrane invasion of cancer cells, thereby exhibiting an inhibitory activity against the growth and/or metastasis of cancer cells.
C07K 5/11 - Tetrapeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/09 - Tripeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
23.
COMPOSITION COMPRISING PEPTIDE DERIVED FROM ADIPONECTIN
KNU-INDUSTRY COOPERATION FOUNDATION (Republic of Korea)
SUPADELIXIR INC. (Republic of Korea)
Inventor
Hahn, Jang-Hee
Lim, Dong-Young
Abstract
Provided is a pharmaceutical or cosmetic composition comprising, as an active ingredient, a peptide fragment derived from adiponectin, that is, a peptide selected from the group consisting of peptides comprising amino acid sequences having sequence numbers 1-6. The peptide promotes skin regeneration and moisturization, and has a suppression activity for wrinkles of the skin, and additionally, has suppression activities for allergy or inflammation and metastasis of cancer cells.
The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX(or XG), which are a kind of transmembrane protein, or a fused protein thereof. The polypeptide or the fused protein thereof has an activating function of inhibiting the extravasation of white blood cells, or inhibiting the growth and/or metastasis of cancer cells. The present invention also provides a polynucleotide coding the polypeptide, a vector including same, and a transformant transformed by the vector. In addition, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof for preventing or treating inflammatory diseases. Further, the present invention provides a is pharmaceutical composition including the polypeptide or the fused protein thereof inhibiting the growth and/or metastasis of cancer cells, i.e., a pharmaceutical composition for preventing or treating cancer.
The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX (or XG), which are a kind of transmembrane protein, or a fused protein thereof. The polypeptide or the fused protein thereof has an activating function of inhibiting the extravasation of white blood cells, or inhibiting the growth and/or metastasis of cancer cells. The present invention also provides a polynucleotide coding the polypeptide, a vector including same, and a transformant transformed by the vector. In addition, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof for preventing or treating inflammatory diseases. Further, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof inhibiting the growth and/or metastasis of cancer cells, i.e., a pharmaceutical composition for preventing or treating cancer.
