Disclosed herein is a catalyst including a multicomponent alloy including a seed and al least four elements. The seed includes at least one platinum group metal, wherein the platinum group metal includes platinum, ruthenium, iridium, palladium, or rhodium. Methods of preparing the catalyst are also provided herein.
B01J 23/54 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of noble metals combined with metals, oxides or hydroxides provided for in groups
A system and method for efficient sampling of ground-state and low-energy Ising configurations. The system may be implemented using the nonlinear stochastic dynamics of a measurement-feedback-based coherent Ising machine (MFB-CIM). A discrete-time Gaussian-state model of the MFB-CIM may capture the nonlinear dynamics. The system and method requires many fewer roundtrips to sample than for other known systems.
CENTRO DE INVESTIGACIONES ENERGÉTICAS, MEDIO AMBIENTASDS Y TECNOLÓGICAS O.A., M.P. (Spain)
CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED (Spain)
FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA FUNDACIÓN JIMÉNEZ DÍAZ (Spain)
STANFORD UNIVERSITY (USA)
Inventor
Bonafont Aragó, José
Larcher Laguzzi, Fernando
Murillas Angoiti, Rodolfo
Del Río Nechaevsky, Marcela
Mencía Rodriguez, Ángeles
García Díez, Marta
Escámez Toledano, María José
Porteus, Matthew
Abstract
The present invention relates to the treatment of Epidermolysis Bullosa, particularly the recessive dystrophic subtype (RDEB), using the Clustered- Regularly Interspaced Short Palindromic Repeats (CRISPR) system. This technology offers the possibility to design a single guide RNA (sgRNA) which is incorporated into a CRISPR- associated protein (Cas9) to recognize and induce DNA double-strand breaks at a specific target location. DNA double-strand breaks will be repaired by homologous recombination (HR) in the presence of a donor sequence for Epidermolysis Bullosa gene repair. In the context of Epidermolysis Bullosa, this allows to repair the mutation/s causing the disease.
Nanoparticles comprising a platinum group metal and a base metal, catalytic compositions comprising such nanoparticles and a support material, and methods of making such nanoparticles and catalytic compositions are disclosed. Catalytic articles and exhaust gas treatment systems, as well as methods of treating an exhaust gas stream comprising a pollutant using these catalytic articles and exhaust gas treatment systems, are also disclosed.
B01J 21/06 - Silicon, titanium, zirconium or hafniumOxides or hydroxides thereof
B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
A system and method for efficient sampling of ground-state and low-energy Ising configurations. The system may be implemented using the nonlinear stochastic dynamics of a measurement-feedback-based coherent Ising machine (MFB-CIM). A discrete-time Gaussian-state model of the MFB-CIM may capture the nonlinear dynamics. The system and method requires many fewer roundtrips to sample than for other known systems.
The present invention is directed to a balloon based system and method for measuring gastrointestinal motility. The balloon can be a stand-alone balloon with pressure sensing capabilities or the balloon can be deployed as a component of a catheter-based system. The balloon can be deployed in an uninflated state and can be inflated with fluid such as air, water, or other biocompatible fluid while disposed within the gastrointestinal tract. The pressure sensor can take the form of a pressure sensor disposed within the balloon or disposed on a surface of the balloon. Additional, sensors can also be applied to monitor other conditions, function, or disease state.
A61B 1/273 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
A lossy compression algorithm is described for performing data compression of high-frequency floating point time-series data, for example. The compression algorithm utilizes a prediction engine that employs at least one of a linear prediction model or a non-linear prediction model to calculate one-step-ahead prediction of a current data value at current sampling time t using N previous quantized data values, where N is the model order. A prediction error is determined between the predicted value and an actual value, and the prediction error is quantized. A quantized current data value is determined from the predicted value and the quantized prediction error. The quantized prediction error is sent from an edge device to a data decompressor on a cloud device. The decompressor reconstructs the quantized current data value using the received quantized prediction error and by generating the same predicted value as the compressor.
KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (Saudi Arabia)
STANFORD UNIVERSITY (USA)
Inventor
Ma, Xiaohua
Pinnau, Ingo
Lai, Holden W.H.
Xia, Yan
Abstract
Embodiments of the present disclosure feature an intrinsically microporous ladder-type Tröger's base polymer including a repeat unit based on a combination of W-shaped CANAL-type and V-shaped Tröger's base building blocks, methods of making the intrinsically microporous ladder-type Tröger's base polymer, and methods of using the intrinsically microporous ladder-type Tröger's base polymer to separate a chemical species from a fluid composition including a mixture of chemical species. Embodiments of the present disclosure further include ladder-type diamine monomers for reacting to form a Tröger's base in situ, and methods of making the ladder-type diamine monomers using catalytic arene-norbornene annulation.
GOTTFRIED WILHELM LEIBNIZ UNIVERSITÄT HANNOVER (Germany)
STANFORD UNIVERSITY (USA)
Inventor
Voges, Jan
Hernaez, Mikel
Ostermann, Jörn
Abstract
The invention relates to a method for encoding of quality values of a data structure, whereby said data structure includes a plurality of continuous fragments, each continuous fragment comprises a sequence of symbols derived from a symbol alphabet and corresponds to a segment of one reference sequence of one or more reference sequences, whereby each continuous fragment is aligned to locus indexes of one of said reference sequence and at least a portion of said continuous fragments overlap at an aligned locus index, and includes, further, a plurality of quality values, each quality value is derived from a quality value alphabet and is assigned to a corresponding symbol of one of the continuous fragments, whereby each quality value indicates a likelihood that the corresponding symbol in the corresponding continuous fragment is correct, wherein the method comprises the steps executable by a data processing system: - determine the quality values at a specific locus index, which are assigned to symbols of continuous fragments aligned to said specific locus index; - calculate an estimation certainty at the specific locus index based on the determined quality values, whereby said estimation certainty indicates a likelihood of correctness for each quality value of the determined quality values in relation to the corresponding symbols; and - encode the determined quality values by transform of each determined quality values into a transformed quality value based on the calculated estimation certainty.
G06F 19/22 - for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or Single-Nucleotide Polymorphism [SNP] discovery or sequence alignment
H03M 7/30 - CompressionExpansionSuppression of unnecessary data, e.g. redundancy reduction
11.
Peptide regulators of mitochondrial fusion and methods of use
Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2) and mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides for use in screening assays are also described.
KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (Saudi Arabia)
UNIVERSITY OF BRITISH COLUMBIA (Canada)
STANFORD UNIVERSITY (USA)
BONN UNIVERSITY (Germany)
Inventor
Heidrich, Wolfgang
Heide, Felix
Wetzstein, Gordon
Hullin, Matthias
Abstract
Systems and methods for imaging object velocity are provided. In an embodiment, at least one Time-of-Flight camera is used to capture a signal representative of an object in motion over an exposure time. Illumination and modulation frequency of the captured motion are coded within the exposure time. A change of illumination frequency is mapped to measured pixel intensities of the captured motion within the exposure time, and information about a Doppler shift in the illumination frequency is extracted to obtain a measurement of instantaneous per pixel velocity of the object in motion. The radial velocity information of the object in motion can be simultaneously captured for each pixel captured within the exposure time. In one or more aspects, the illumination frequency can be coded orthogonal to the modulation frequency of the captured motion. The change of illumination frequency can correspond to radial object velocity.
G01S 17/58 - Velocity or trajectory determination systemsSense-of-movement determination systems
G01S 17/32 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated
G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
13.
CARBONATE-PROMOTED CARBOXYLATION REACTIONS FOR THE SYNTHESIS OF VALUABLE ORGANIC COMPOUNDS
A method for synthesizing furan-2, 5-dicarboxylate (FDCA2-) is provided. Furan-2-carboxylic acid is provided. A CO32- salt is provided to form a mixture, which converts the furan-2-carboxylic acid to furan-2-carboxylate. CO2 gas is provided to a mixture of the furan-2-caboxylic acid and CO32- salt. The mixture is heated to a temperature to at least partially melt the furan-2-caboxylate.
The present invention provides a method of treating cancer with a combination of IL- 2 and an integrin-binding-Fc fusion protein. The methods of the invention can be applied to a broad range of cancer types.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
STANFORD UNIVERSITY (USA)
Inventor
Agaian, Sos
Mosquera-Lopez, Clara M.
Greenblatt, Aaron
Abstract
Described herein are systems and methods for performing multi-stage detection and classification of cancer regions from digitized images of biopsy slides. Novel methods for processing the digitized images to improve feature extraction and structure identification are disclosed, including but not limited to the use of quaternions, logarithmic mappings of color channels, and application of wavelets to logarithmic color channel mappings. The extracted features are utilized in improved machine learning algorithms that are further optimized to analyze multiple color channels in multiple dimensions. The improved machine learning algorithms include techniques for accelerating the training of the algorithms, making their application to biopsy detection and classification practical for the first time. The performance of the described systems and methods are further improved by the disclosure of a novel multistage machine learning scheme, in which additional classifiers are utilized to choose among the classes proposed by other classifiers in close cases.
Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface attachment features that are spaced apart on the surface such that when the analytes are labeled adjacent analytes are optically resolvable from each other. One way to express this concept is that binding elements should be spaced apart such that the Guassian point spread functions of adjacent labels do not overlap. Another way of expressing this concept is that the surface binding elements should be spaced apart by a distance equal to at least the diffraction limit for an optical label attached to the bound analytes.
The invention relates to chemerin peptides, pharmaceutical compositions containing these peptides and use of these peptides for treating pathological epithelium, in particular for use against bacterial and fungal infections and for treating diseases associated with injury or inflammation of the skin, lungs or gastrointestinal tract.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
The present invention provides a method, device and a computer program for haplotyping single cells, such that a sample taken from a pregnant female, without directly sampling the fetus, provides the ability to non-invasively determine the fetal genome. The method can be performed by determining the parental and inherited haplotypes, or can be performed merely on the basis of the mother's genetic information, obtained preferably in a blood or serum sample. The novel device allows for sequence analysis of single chromosomes from a single cell, preferably by partitioning single chromosomes from a metaphase cell into long, thin channels where a sequence analysis can be performed.
The invention provides a non-invasive technique for the differential detection of multiple genotypes and/or mutations for a plurality of target genes in a biological sample containing genetic material from different genomic sources. Methods are conducted using multiplex amplification of a plurality of target sequences from the biological sample, and sequencing is used to detect and enumerate genetic mutations and chromosomal abnormalities at the single nucleotide level.
The invention provides a non-invasive technique for the differential detection of multiple genotypes and/or mutations for a plurality of target genes in a biological sample containing genetic material from different genomic sources. Methods are conducted using multiplex amplification of a plurality of target sequences from the biological sample, and sequencing is used to detect and enumerate genetic mutations and chromosomal abnormalities at the single nucleotide level.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES (France)
STANFORD UNIVERSITY (USA)
Inventor
Tirouvanziam, Rabindra
Laval, Julie
Battini, Jean-Luc
Sitbon, Marc
Abstract
The invention relates to a method for the diagnosis and/or prognosis of inflammatory states. We describe the use of at least one soluble receptor-binding (RBD), for the identification and quantication of the expression of membrane receptors present on the surface of target granulocytes, said identification and quantification taking place at a given time or during a given time interval, and allowing the diagnosis and/or prognosis of inflammatory states in a mammal.
Various methods for tracking and recognition with rotation invariant feature descriptors are provided. One example method includes generating an image pyramid of an image frame, detecting a plurality of interest points within the image pyramid, and extracting feature descriptors for each respective interest point. According to some example embodiments, the feature descriptors are rotation invariant. Further, the example method may also include tracking movement by matching the feature descriptors to feature descriptors of a previous frame and performing recognition of an object within the image frame based on the feature descriptors. Related example methods and example apparatuses are also provided.
A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.
A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.
Techniques for radioablation of sympathetic nerves include positioning a subject on a support in view of a volume imaging system and an ionizing radiation source; and collecting volume image data. Location of a treatment portion of a sympathetic nerve in the subject is determined based on the volume image data. Movement of the source is determined to apply a therapeutic radiation dose to the treatment portion based on the location of the treatment portion and relative location of the source to the volume imaging system. The source is operated to deliver the therapeutic radiation dose. An apparatus includes a mounting structure, an X-ray source and a shield. The source produces an X-ray beam with photon energy above one million electron volts (MeV) and not above six MeV. The shield is mounted in opposition to the source to block the X-ray beam with photon energies not greater than about six MeV.
Various methods for tracking and recognition with rotation invariant feature descriptors are provided One example method includes generating an image pyramid of an image frame, detecting a plurality of interest points within the image pyramid, and extracting feature descriptors for each respective interest point According to some example embodiments, the feature descriptors are rotation invariant Further, the example method may also include tracking movement by matching the feature descriptors to feature descriptors of a previous frame and performing recognition of an object within the image frame based on the feature descriptors Related example methods and example apparatuses are also provided.
A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.
The disclosure relates to methods and materials useful for polymerizing a monomer. In one embodiment, for example, the disclosure provides a method for polymerizing a monomer containing a plurality of electrophilic groups, wherein the method comprises contacting the monomer with a nucleophilic reagent in the presence of a guanidine-containing catalyst. The methods and materials of the disclosure find utility, for example, in the field of materials science.
A method, apparatus and computer program product may be provided for generating a plurality of compressed feature descriptors that can be represented by a relatively small number of bits, thereby facilitating transmission and storage of the feature descriptors. A method, apparatus and computer program product may also be provided for permitting a compressed representation of a feature descriptor to be compared with a plurality of compressed representations of feature descriptors of respective predefined features. By permitting the comparison to be performed utilizing compressed representations of feature descriptors, a respective feature descriptor may be identified without having to first decompress the feature descriptor, thereby potentially increasing the efficiency with which feature descriptors may be identified.
G06F 17/30 - Information retrieval; Database structures therefor
G06K 9/46 - Extraction of features or characteristics of the image
G06K 9/64 - Methods or arrangements for recognition using electronic means using simultaneous comparisons or correlations of the image signals with a plurality of references, e.g. resistor matrix
A method of use of a cysteine labeling system including: providing a 2-cyano benzothial core with a covalently-linked biomolecule X in a reaction environment; and reacting the 2-cyano benzothial core to an N-terminal cystenine.
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 417/02 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings
A61K 31/541 - Non-condensed thiazines containing further heterocyclic rings
32.
ACTIVATABLE BIOLUMINESCENT PROBE SYSTEM AND METHOD OF USE THEREOF
A method of use of an activatable bioluminescent probe system includes: providing a bioluminescent protein and a quencher in a reaction environment; modifying a ligand between the quencher and the bioluminescent protein using a ligand interacting molecule; adding a bioluminescence initiating molecule to the reaction environment; and measuring light originating from the interaction between the bioluminescent protein and the bioluminescence initiating molecule.
Short hairpin RNA (shRNA) interference therapy targeting hypoxia inducible factor- lot (HIF-1 α) prolyl-4-hydroxylase protein (HIF-PHD2) is used for treatment of myocardial ischemia. This treatment can be followed noninvasively by molecular imaging. Provided are compositions comprising novel vectors encoding shRNA targeting the HIF-1α and asparaginyl hydroxylase genes. The vectors encoding shRNA are also useful for the treatment of cardiac diseases, peripheral vascular diseases and decubitis ulcers.
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61P 9/00 - Drugs for disorders of the cardiovascular system
34.
ACCELERATED MOLECULAR DYNAMICS OF PROTEINS AND OTHER BIOMOLECULES
Embodiments herein relate to the field of computational biochemistry, in particular to accelerated molecular dynamics of proteins and other biomolecules. Various embodiments disclosed herein include methods, systems, and apparatus for determining the state, for example the kinetics or thermodynamics, of a biomolecule system. In some embodiments, the methods include partitioning the system's degrees of freedom into a subspace and a subspace complement according to frequency using Normal Mode Analysis (NMA), determining a harmonic approximation to the system around an initial equilibrium structure using a Mass Reweighted Hessian (MRH) of a biomolecular force field, using the partitioning to construct a damping matrix for the Langevin equation that overdamps and propagates high frequency modes using Brownian dynamics, propagating the low frequency modes using full Langevin dynamics, and accelerating the Brownian dynamics on the high frequency modes using an energy minimization. A coarse-grained normal mode analysis (CNMA) is also presented that enables application of this approach to very large proteins and long timescales.
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
35.
System and method for using prospective evaluation of displacement and velocity of a respiratory trace in a five dimensional parameter space to reduce artifacts and dosage in four dimensional computed tomography
A displacement and velocity based prospective cine CT (PDV CT) method is disclosed for starting image acquisition if the displacement and velocity are simultaneously within predetermined tolerances, thus essentially sorting 2D CT images in a five dimensional parameter space, where displacement and the sign of the velocity are used for the temporal sorting, replacing the use of either phase or displacement as the temporal parameter during retrospective sorting, with velocity as a separate parameter correlating to some parameter of the system, e.g. the airflow rate, making it possible to do the image sorting in real-time.
The present disclosure provides for compounds, pharmaceutical preparations, kits and methods for the inhibition of the Hh pathway and the alleviation of cancer and developmental disorders associated with the Hh pathway.
Embodiments of the present disclosure provide: methods of imaging the location and survival of an engineered cell in a host (e.g., human) with an imaging reporter probe, methods of imaging the location and survival of an engineered cell in a host, and, kits, engineered cells, and methods of making the engineered cells, and the like.
Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
39.
SYSTEM AND METHOD FOR PROVIDING INFORMATION IN A VEHICLE
A system for providing information to a vehicle occupant includes a haptic control element which is provided in the vehicle and is configured to generate a haptic signal. An electronic control unit is operatively connected to the haptic control element and activates the haptic control element in order to indicate with a haptic signal that information is available for retrieval.
B60W 40/00 - Estimation or calculation of driving parameters for road vehicle drive control systems not related to the control of a particular sub-unit
B60W 40/08 - Estimation or calculation of driving parameters for road vehicle drive control systems not related to the control of a particular sub-unit related to drivers or passengers
B60W 40/10 - Estimation or calculation of driving parameters for road vehicle drive control systems not related to the control of a particular sub-unit related to vehicle motion
40.
METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION AND COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION
Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of treating HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3'UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.
A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, AND SCREENING ASSAYS FOR IDENTIFYING COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION
Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of identifying a candidate agent for the treatment of hepatitis C virus (HCV) infection, and the like.
A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
42.
MOLECULAR IMAGING OF LIVING SUBJECTS USING RAMAN SPECTROSCOPY AND LABELED RAMAN NANOPARTICLES
Methods of imaging a living host using Raman nanoparticles; methods of generating a true image of a living host having been administered Raman nanoparticles; methods of multiplex imaging of a living host using a plurality of Raman nanoparticles; methods of generating multimodality images by combining Raman images with other functional/anatomical images; labeled Raman nanoparticles; and the like, are provided.
A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.
Embodiments of the present disclosure provide for photoacoustic probes, methods of determining the presence and location of a specific target, methods of determining the presence and location of an enzyme, methods of determining the presence and location of a specific target and an enzyme, and the like.
Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface attachment features that are spaced apart on the surface such that when the analytes are labeled adjacent analytes are optically resolvable from each other. One way to express this concept is that binding elements should be spaced apart such that the Guassian point spread functions of adjacent labels do not overlap. Another way of expressing this concept is that the surface binding elements should be spaced apart by a distance equal to at least the diffraction limit for an optical label attached to the bound analytes.
The present invention is based, in part, on our discovery that EGF can be engineered to generate mutants that bind to the EGF receptor (EGFR) of a cell and that have a desirable effect on the activity of the cell. For example, the mutants can agonize the receptor (i.e., increase a biological activity of the receptor), or antagonize the receptor (i.e., decrease or inhibit a biological activity of the receptor). In turn, the rate at which the cell proliferates, for example, can be changed. Moreover, some of these mutants bind EGFR with a higher affinity than wild-type EGF exhibits. The affinity may increase by about, for example, 2-, 5-, 10-, 15-, 20-, 25-, 30-, 50-, or 100-fold relative to wild-type EGF.
A01N 37/18 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N, e.g. carboxylic acid amides or imidesThio-analogues thereof
C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
Described here are polymer compositions, methods, and systems for reinforcing a wall of a heart. The polymer compositions may be adapted to form networks, e.g., cross-linked networks, semi-interpenetrating networks, or interpenetrating networks, and placed within the pericardial space or on one or more pericardial tissues. The mechanical properties of the polymer compositions or networks derived therefrom may then be employed to reinforce a heart wall to prevent dilatation of a chamber of the heart and/or expansion of an infarct, e.g., to treat or prevent congestive or chronic heart failure.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
48.
BIOACTIVE MATERIAL DELIVERY SYSTEMS COMPRISING SOL-GEL COMPOSITIONS
Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed.
The invention encompasses methods for improving the level and/or suslainability of expression for a target nucleic acid in a eukaryotic cell comprising: (a) modifying the target nucleic acid to introduce or to comprise signals that limit or constrain the positions of nucleosome cores, and (b) introducing the modified target nucleic acid into the eukaryotic cell, wherein the modified target nucleic acid has improved levels and/ or sustainability of expression compared to original unmodified nucleic acid.
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
A01N 43/04 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom
A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
Generally, aspects of the present disclosure are directed to conjugate systems, self-illuminating quantum dot conjugates, methods of detecting a target in a host, methods of treating a disease in a host, and the like.
An improved method and apparatus for respiratory audio-visual biofeedback are disclosed. A guide patterned after a breathing cycle comfortable to the patient serves as a target. The target is displayed as a bar moving vertically upward during inhale and vertically downward during exhale, between fixed end ex-hale and end in-hale limits. The patient's current respiratory position is also displayed as a bar, oriented parallel to the target bar so that the difference between the current position and the target position is easy for the patient to see.
Computed axial tomography images of different respiratory phases of lungs are obtained, where the intensity of the image measures lung density. One image is deformed to the coordinate space of the other image, and the differences between the intensity values of the other image as compared to the mapped image are evaluated as measures of ventilation.
Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
C12N 15/52 - Genes encoding for enzymes or proenzymes
C07K 14/485 - Epidermal growth factor [EGF], i.e. urogastrone
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
A microwave imaging microscope and associated probe, or a read head. The probe or the read head includes a sensor unit with three fixed electrodes, preferably a stimulating electrode surrounding a sensing electrode and isolated by a grounded electrode. Circuitry couples the stimulating electrode to the probe signal variably selected in the range of 100 MHz to 100 GHz and couples the sensing electrode to a signal processor detecting in-phase and out-of-phase components of the current or voltage across the sensing electrode and the grounded electrode. A mechanical positioner moves the probe vertically towards the sample and scans it across the sample. The probe may be formed by semiconductor processing methods on a silicon chip.
G01R 27/04 - Measuring real or complex resistance, reactance, impedance, or other two-pole characteristics derived therefrom, e.g. time constant in circuits having distributed constants
G01R 31/02 - Testing of electric apparatus, lines, or components for short-circuits, discontinuities, leakage, or incorrect line connection
G01N 23/00 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or
55.
Methods for performing fast discrete curvelet transforms of data
The inventors have discovered a collection of proteinaceous biomarkers ("AD" biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels.
An agent that receives an input event and outputs Emotion_Response messages based on personality trait indices and emotional state indices is disclosed. The agent has a social response generator that receives an input event, an output from an emotional state register and an output from a predefined personality trait register, and updates at least one of a current state of the emotional state register or a Social_Response message stored an event buffer. The agent has an emotion generator that outputs an Emotion_Response message based on at least one of the Social_Response message stored in the event buffer, one or more outputs of the predefined personality trait register, or one or more outputs of the emotional state register. The agent operates within an environment server that provides contextual environment that facilitates interaction amongst a group of agents, which receive input events from the contextual environment and outputs emotional response messages thereto.
Novel double and triple fusion reporter gene constructs harboring distinct imageable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in living cells and in living animals using distinct imaging technologies.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 38/02 - Peptides of undefined number of amino acidsDerivatives thereof
C07K 2/00 - Peptides of undefined number of amino acidsDerivatives thereof
C12N 15/62 - DNA sequences coding for fusion proteins
patents
