Abstract

This invention provides a measure that makes it possible to prevent more effectively, in comparison with the prior art, the invasion of germs from the gap between a dental prosthesis and the gingiva when the dental prosthesis is used in an oral cavity as well as the infection and inflammation associated therewith. There is a dental prosthesis or a component thereof, characterized in that: the dental prosthesis or the component thereof has hydroxyapatite fine particles on a surface of the dental prosthesis or the component thereof; the hydroxyapatite fine particles are sintered bodies; and the hydroxyapatite fine particles have a mean particle size of 10 to 1,000 nm.

IPC Classes  ?

• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereonDental implantsImplanting tools
• A61C 13/09 - Multilayer teeth
• A61K 6/838 - Phosphorus compounds, e.g. apatite
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/40 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material

Abstract

This invention has an object to provide a means for providing a calcium phosphate sintered body particle group that does not cause a phenomenon of bubble generation in any use mode thereof, and further has a smaller particle diameter. There is provided a ceramic particle group containing spherical ceramic particles, which is characterized in that the ceramic particle has a particle diameter within a range of 10 nm to 700 nm, and is a calcium phosphate sintered body particle, and further the ceramic particle group contains no calcium carbonate.

IPC Classes  ?

• C04B 35/447 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on phosphates
• A61K 6/838 - Phosphorus compounds, e.g. apatite
• A61L 27/32 - Phosphorus-containing materials, e.g. apatite
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• C04B 35/64 - Burning or sintering processes

Abstract

To provide a ceramic particle separable composite material having a calcium phosphate sintered body particle with which bioaffinity reduction and solubility change are suppressed as much as possible and which has a smaller particle diameter. A ceramic particle separable composite material comprising a ceramic particle and a substrate, wherein: the ceramic particle and the substrate are chemically bonded to each other, or the ceramic particle physically adheres to or is embedded in the substrate; the ceramic particle has a particle diameter within a range of 10 nm to 700 nm; the ceramic particle is a calcium phosphate sintered body particle; and the ceramic particle contains no calcium carbonate.

IPC Classes  ?

• A61L 31/02 - Inorganic materials
• A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
• A61L 27/10 - Ceramics or glasses
• A61L 29/02 - Inorganic materials
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• C04B 35/447 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on phosphates
• C04B 35/622 - Forming processesProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
• A61L 31/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
• A61L 29/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
• A61L 15/64 - Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
• A61L 27/40 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
• A61K 6/838 - Phosphorus compounds, e.g. apatite

Abstract

To provide a technology for sintering calcium phosphate to manufacture a calcium phosphate sintered body and suppressing generation of calcium oxide when calcium phosphate is sintered, there is provided a process for manufacturing a sintered calcium phosphate molded body is characterized by including a step for heating a composition containing at least a composite of calcium phosphate fine particles and polyether and sintering the calcium phosphate fine particles.

IPC Classes  ?

• C04B 35/447 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on phosphates
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• C04B 38/06 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof by burning-out added substances
• C04B 35/634 - Polymers
• C04B 35/626 - Preparing or treating the powders individually or as batches
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• A61L 31/00 - Materials for other surgical articles
• B01J 20/04 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
• C04B 111/00 - Function, property or use of the mortars, concrete or artificial stone

Abstract

[Problem] To provide a ceramic particle carrying medical tube and/or cuff that has excellent cell adhesiveness, etc. [Solution] A medical tube and/or cuff carrying ceramic particles in at least part thereof and characterized by: the particle size of the ceramic particles being 10-700 nm; the ceramic particles being calcium phosphate sintered particles; and the ceramic particles not containing calcium carbonate.

IPC Classes  ?

• A61L 29/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
• A61L 29/02 - Inorganic materials
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium

Abstract

[Problem] To provide a means whereby, regardless of the mode of use, calcium phosphate sintered particle groups having a smaller particle size can be provided without causing bubble generation events. [Solution] A ceramic particle group including spherical ceramic particles and characterized by: the particle size of the ceramic particles being 10-700 nm; the ceramic particles being calcium phosphate sintered particles; and the ceramic particle group not containing calcium carbonate.

IPC Classes  ?

• C04B 35/447 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on phosphates
• A61K 6/033 - Phosphorus compounds, e.g. apatite
• A61L 27/32 - Phosphorus-containing materials, e.g. apatite
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium

Abstract

[Problem] To provide a ceramic particle releasable composite material that reduces biocompatibility reduction and solubility changes as much as possible and has calcium phosphate sintered particles having a smaller particle size. [Solution] A ceramic particle releasable composite material characterized by: being a composite material including ceramic particles and a base material; being a ceramic particle composite material having the ceramic particles and the base material chemically bonded or the ceramic particles physically attached to or embedded in the base material; the particle size of the ceramic particles being 10-700 nm; the ceramic particles being calcium phosphate sintered particles; and the ceramic particles not containing calcium carbonate.

IPC Classes  ?

• A61L 27/10 - Ceramics or glasses
• A61K 6/033 - Phosphorus compounds, e.g. apatite
• A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
• A61L 15/64 - Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
• A61L 27/40 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
• A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
• A61L 29/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
• A61L 31/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• C04B 35/447 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on phosphates

Abstract

[Problem] To provide a novel stent having excellent cell adhesiveness, etc. [Solution] A stent carrying ceramic particles and characterized by: the particle size of the ceramic particles being 10-700 nm; the ceramic particles being calcium phosphate sintered particles; and the ceramic particles not containing calcium carbonate.

IPC Classes  ?

• A61L 31/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
• A61L 31/02 - Inorganic materials

Abstract

[Problem] To provide a means for producing a calcium phosphate sintered body particle group which does not cause the phenomenon of bubble generation regardless of the way the same is used and which has smaller particle sizes. [Solution] In the present invention, a ceramic particle group includes spherical ceramic particles, and is characterized in that the particle size of the ceramic particles is in the range of 10 to 700 nm, the ceramic particles are calcium phosphate sintered body particles, and the ceramic particle group does not include calcium carbonate.

IPC Classes  ?

• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium

Goods & Services

Chemicals for use as raw materials of cosmetics; reagents for research use. Toothpaste; skin care products. Dietary supplements. Medical equipment; medical apparatus; medical devices. Developing medical apparatus and medical devices; providing support for developing medical apparatus and medical devices; providing technical information; providing electronic microscope imaging services and providing electronic microscope images; Consulting services in the field of medical apparatus development.

Abstract

[Problem] To provide a means that, during the intraoral use of a dental prosthesis, can more effectively stop the invasion of bacteria from between the dental prosthesis and the gums and the infection as well as inflammation associated therewith, in comparison to the prior art. [Solution] A dental prosthesis or a component thereof characterized in that: the dental prosthesis or the component thereof has hydroxyapatite microparticles on the surface of the dental prosthesis or the component thereof; the hydroxyapatite microparticles are sintered bodies; and the average particle size of the hydroxyapatite microparticles is 10 to 1,000 nm.

IPC Classes  ?

• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereonDental implantsImplanting tools
• A61K 6/033 - Phosphorus compounds, e.g. apatite
• A61L 27/40 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material

Abstract

2/mL when measurement is carried out by mercury porosimetry.

IPC Classes  ?

• B01J 20/282 - Porous sorbents
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• C07K 1/16 - ExtractionSeparationPurification by chromatography
• C07K 16/06 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies from serum
• C12N 9/36 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-1, 4 bonds between N-acetylmuramic acid and 2-acetylamino 2-deoxy-D-glucose, e.g. lysozyme

Abstract

[Problem] To provide a technique for producing a calcium phosphate sintered body by sintering calcium phosphate such that calcium oxide generation is minimized when sintering. [Solution] A method for producing a sintered calcium phosphate body characterized by including a step of heating a composition which includes at least a composite of calcium phosphate particles and polyether and sintering the calcium phosphate particles together.

IPC Classes  ?

• C04B 35/447 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on phosphates
• A61L 31/00 - Materials for other surgical articles
• B01J 20/04 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• C04B 38/06 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof by burning-out added substances

Abstract

Provided is an improved biocompatible immune adjuvant. More specifically, provided are: an immune adjuvant that comprises calcium phosphate, preferably hydroxyapatite, having an average particle size of about 40 nm exclusive to about 1800 nm exclusive; a medicine that comprises this immune adjuvant; and a vaccine that comprises this immune adjuvant. Rod-shaped HAp induced inflammasome-dependent IL-1β production in vitro more strongly than spherical HAp. In WT mice, however, spherical HAp and rod-shaped HAp induced equivalent antigen responses.

IPC Classes  ?

• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

An inner surface-modified tube includes fine particles that are buried in an inner surface of a tube with part of surfaces of the fine particles exposed, wherein the fine particles are unevenly distributed such that more fine particles are distributed in a region from a center of the tube to the inner surface of the tube than in a region from the center of the tube to an outer surface of the tube based on a thickness direction of the tube, an arithmetic average roughness Ra of the inner surface of the tube is 1 nm or more and 100 μm or less, a particle diameter of each fine particle is 10 nm or more and 100 μm or less, and an inner diameter of the tube is 0.01 mm or more and 100 mm or less.

IPC Classes  ?

• B05B 7/14 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas designed for spraying particulate materials
• B05D 1/12 - Applying particulate materials
• B29C 48/32 - Extrusion nozzles or dies with annular openings, e.g. for forming tubular articles
• C23C 4/11 - Oxides
• F16L 58/04 - Coatings characterised by the materials used
• B29C 48/30 - Extrusion nozzles or dies
• C23C 24/02 - Coating starting from inorganic powder by application of pressure only
• B29L 23/00 - Tubular articles

Abstract

[Problem] To provide an inner face modified tube to which a surface modification treatment was implemented on the inner face of the tube in order to add prescribed functionality and which can exhibit sufficiently the added functionality and maintain the functionality over a long period. [Solution] An inner face modified tube (100) has particles (120) embedded in the inner face of a tube (110) in a state of partial exposure, wherein: the particles (120) are more unevenly distributed, on the basis of the thickness direction of the tube (110), in an area (A2) from the center (C) of the tube (110) toward the inner face of the tube (110) than in an area (A1) from the center (C) of the tube (110) toward the outer face of the tube (110); the material constituting the particles (120) is a material that does not bond covalently or ionically with the material constituting the inner face of the tube (110); the mean roughness (Ra) of the inner face of the tube (110) is no less than 1 nm and no more than 100 μm; the particle diameter of the particles (120) is no less than 10 nm and no more than 100 μm; and the inner diameter of the tube (110) is no less than 0.01 mm and no more than 100 mm.

IPC Classes  ?

• F16L 58/04 - Coatings characterised by the materials used
• F16L 11/12 - Hoses, i.e. flexible pipes made of rubber or flexible plastics with arrangements for particular purposes, e.g. specially profiled, with protecting layer, heated, electrically conducting

Abstract

[Problem] To provide a biodegradable material that has sufficient mechanical strength, considering in vivo use also, and that can suppress pH changes caused by an acidic degradation product. [Solution] Provided is a biodegradable material the base material of which is polyester, and that is characterized by comprising calcium phosphate particles having an average particle diameter of 10 to 1,000 nm.

IPC Classes  ?

• C08L 67/00 - Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chainCompositions of derivatives of such polymers
• A61L 29/00 - Materials for catheters or for coating catheters
• A61L 31/00 - Materials for other surgical articles
• C08K 3/32 - Phosphorus-containing compounds
• C08L 101/16 - Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable

Abstract

In the present invention, a mixed solution is manufactured by adding a thiol to a solution containing silver ions, and silver particles are manufactured by aggregating the silver ions using a method comprising the steps of adjusting the amount of the thiol added to the solution and adding a reducing agent to the mixed solution, whereby the particle size and antimicrobial activity of the silver particles are easily adjusted.

IPC Classes  ?

• B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
• A01N 25/12 - Powders or granules
• A01N 59/16 - Heavy metalsCompounds thereof
• A01P 3/00 - Fungicides
• B22F 1/00 - Metallic powderTreatment of metallic powder, e.g. to facilitate working or to improve properties
• B22F 1/02 - Special treatment of metallic powder, e.g. to facilitate working, to improve properties; Metallic powders per se, e.g. mixtures of particles of different composition comprising coating of the powder

Abstract

Provided is a functional nonwoven fabric that feels good in terms of drape (softness), texture, etc. when used and is capable of stably exhibiting the characteristics of hydroxyapatite (for example, microbe-adsorption, etc.). A functional nonwoven fabric in which fired hydroxyapatite particles are fixed by heat-sealing to the surface of a nonwoven fabric comprising fibers in which at least the surfaces are mainly obtained from a thermoplastic resin. The shearing rigidity of the functional nonwoven fabric is 8.5 gf/cm or less.

IPC Classes  ?

• D06M 11/71 - Salts of phosphoric acids
• A61C 17/00 - Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prosthesesSaliva removersDental appliances for receiving spittle
• B01J 20/04 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• D06M 23/08 - Processes in which the treating agent is applied in powder or granular form

Abstract

To provide a method for producing a porous calcium phosphate body that has micropores communicating with each other. A porous calcium phosphate body that has uniform micropores communicating with each other can be produced by a method for producing a porous calcium phosphate body, wherein calcium phosphate is electrostatically spun.

IPC Classes  ?

• D01F 9/08 - Man-made filaments or the like of other substancesManufacture thereofApparatus specially adapted for the manufacture of carbon filaments of inorganic material
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium

Abstract

The main purpose of the present invention is to provide: composite particles which can hold transplanted cells thereon satisfactorily for a period of time until the effect of the cells is developed; and a cell preparation comprising the composite particles and cells supported on the composite particles. The purpose can be achieved by composite particles each of which comprises inorganic particles adsorbed on the surface of a particle comprising an L-lactide-ε-caprolactone copolymer, wherein the constitutional molar ratio of L-lactide to an ε-caprolactone copolymer in the copolymer is approximately 75/25. The present invention also provides a cell preparation comprising cell-supported composite particles, which comprises cell-supported composite particles produced by supporting cells on the above-mentioned composite particles.

IPC Classes  ?

• C08J 3/12 - Powdering or granulating
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 47/02 - Inorganic compounds
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61L 27/00 - Materials for prostheses or for coating prostheses
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C08K 3/32 - Phosphorus-containing compounds
• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones

Abstract

[Problem] To provide a novel breast enhancement accelerator. [Solution] The present inventor perfected the present invention having discovered a novel attribute in which collagen production is accelerated when calcium phosphate microparticles come into contact with fibroblasts, and having further discovered a novel attribute in which breast enhancement effect is obtained by application of such microparticles to the breasts. More specifically, the present invention is a breast enhancement accelerator characterized by containing calcium phosphate microparticles.

IPC Classes  ?

• A61K 33/42 - PhosphorusCompounds thereof
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61P 17/00 - Drugs for dermatological disorders
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

Disclosed is a novel collagen production enhancer for increasing the amount of collagen contained in the skin tissues. The collagen production enhancer is characterized by containing calcium phosphate fine particles as an active ingredient.

IPC Classes  ?

• A61K 33/42 - PhosphorusCompounds thereof
• A61K 9/14 - Particulate form, e.g. powders
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein

Abstract

Disclosed is a means for immobilizing calcium phosphate on the surface of a metal through a treatment process which uses no acid and produces little residual materials. Specifically disclosed is a method for producing a calcium phosphate complex which comprises a base material and calcium phosphate bound to the surface of the base material.  The method comprises the following steps: a surface treatment step of contacting the surface of the base material with a surface-treating agent and subsequently contacting the surface with a silane coupling agent to treat the surface; a polymerization step, subsequent to the surface treatment step, of initiating the polymerization of the silane coupling agent with a polymerization initiator; and a binding step of binding calcium phosphate to the silane coupling agent present on the surface of the base material after the polymerization step, wherein the base material is a metal and the surface-treating agent is aqueous ozone.

IPC Classes  ?

• C23C 22/78 - Pretreatment of the material to be coated
• C23C 22/00 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals

Abstract

Provided is a tooth surface repairing material which can produce an effect in a short time while preventing fine particles from shedding. The tooth surface repairing material contains fine calcium phosphate particles, and is characterized in that the fine calcium phosphate particles are highly crystalline sintered calcium phosphate and have an average particle diameter in the range of 20-100 nm.

IPC Classes  ?

• A61K 6/00 - Preparations for dentistry