Abstract

An extruder for hybrid microcatheters comprises an extrusion die, a commuter element and several resin sources, the commuter clement allowing for resin selection.

IPC Classes  ?

• B29C 48/49 - Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using two or more extruders to feed one die or nozzle
• A61M 25/00 - CathetersHollow probes
• B29C 48/09 - Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels
• B29C 48/19 - Articles comprising two or more components, e.g. co-extruded layers the components being layers the layers being joined at their edges
• B29C 48/50 - Details of extruders
• B29L 31/00 - Other particular articles

Abstract

The present invention relates to an extruder for hybrid microcatheters comprising an extrusion die, a commuter element and several resin sources, the commuter element allowing for resin selection.

IPC Classes  ?

• B29C 48/495 - Feedblocks
• B29C 48/325 - Extrusion nozzles or dies with annular openings, e.g. for forming tubular articles adjustable
• B29C 48/09 - Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels
• B29C 48/19 - Articles comprising two or more components, e.g. co-extruded layers the components being layers the layers being joined at their edges
• B29C 48/30 - Extrusion nozzles or dies
• A61M 25/00 - CathetersHollow probes

Abstract

The present invention relates to improved clot retrieval devices, wherein at least the part of the device intended to be in contact with a clot is coated with at least one chromatin binding agent selected from the group consisting of digoxigenin, a digoxigenin derivative, distamycin and a distamycin derivative. The present invention also relates to a method of producing said improved clot retrieval device. The present invention also relates to a method of prevention and/or treatment of stroke in a subject, comprising removing at least one clot using the clot retrieval device coated with said least one chromatin binding agent.

IPC Classes  ?

• A61B 17/221 - Calculus gripping devices in the form of loops or baskets
• A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
• C08K 5/3415 - Five-membered rings
• C09D 179/02 - Polyamines
• A61L 31/10 - Macromolecular materials

Abstract

Disclosed is a method for the modification of the surface of a metallic implantable device for interventional neuroradiology by grafting a CD31-derived peptide onto the surface of the device, wherein the CD31-derived peptide consists of a sequence selected from: SEQ ID NO: 2 to 8, SEQ ID NO: 12 to 79, and SEQ ID NO: 81, the method includes: a) coating a polydopamine layer onto the surface of the device in order to obtain a polydopamine coated surface; b) modifying the polydopamine coated surface by adding a linker including at least one reactive moiety chosen from alkyne functions, to obtain a modified polydopamine coated surface; and c) adding a CD31-derived peptide including an azide terminal group and its reaction with the alkyne function of the linker of step b), to obtain a polydopamine coated surface grafted by a CD31-derived peptide.

IPC Classes  ?

• A61L 31/02 - Inorganic materials
• A61L 31/10 - Macromolecular materials
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances

Abstract

The present invention relates to a method for the modification of the surface of a metallic implantable device for interventional neuroradiology by grafting a CD31 - derived peptide onto the surface of said device, wherein the CD31 -derived peptide consists of a sequence selected from the group consisting of: SEQ ID NO: 2 to 8, SEQ ID NO: 12 to 79, and SEQ ID NO: 81, said method comprising the following steps: a) the coating of a polydopamine layer onto the surface of the device in order to obtain a polydopamine coated surface; b) the modification of the polydopamine coated surface by the addition of a linker comprising at least one reactive moiety chosen from alkyne functions, in order to obtain a modified polydopamine coated surface; and c) the addition of a CD31 -derived peptide comprising an azide terminal group and its reaction with the alkyne function of the linker of step b), in order to obtain a polydopamine coated surface grafted by a CD31-derived peptide.

IPC Classes  ?

• A61L 31/02 - Inorganic materials
• A61L 31/10 - Macromolecular materials
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances

Abstract

A catheter includes a tubular body having a channel having its ends opening out respectively at the ends of the tubular body, injector element for injecting fluid into the channel, a tubular endpiece having a channel with ends opening out respectively at the ends of the tubular endpiece, and element for connecting the endpiece and the body together so that the end of the channel and the end of the channel are in alignment on an axis, the connection element being constituted essentially by a ring that partially covers the body and the endpiece, and being also arranged in such a manner that the connection can be broken by exerting a force couple of predetermined value respectively on the endpiece and on the body. The invention is applicable to safety catheters for performing endovascular treatments by injecting embolic fluid, for example for treating arteriovenous malfunctions.

IPC Classes  ?

• A61M 25/16 - Making or assembling not otherwise provided for

Abstract

The invention relates to catheters. The inventive catheter is essentially characterised by the fact that it consists of: a tubular body (1) comprising a channel (4), the ends (5, 6) of which open at the respective ends (2, 3) of the tubular body; injection means (10) for injecting fluid into the channel (4); a tubular end piece (20) comprising a channel (23), the ends (24, 25) of which open at the respective ends (21, 22) of the tubular end piece; and means (30) for connecting the end piece (20) and the body (1) such that the end (24) of one channel (23) and the end (6) of the other channel (4) are coaxial (40). The connection means (30) essentially comprise a ring (31) which partially covers the body and the end piece and are arranged such that, by exerting a couple of forces of pre-determined value in relation to the end piece (20) and the body (1), the aforementioned connection is broken. The invention is suitable for safety catheters for endovascular treatments involving the injection of an embolic liquid, for example for the treatment of arteriovenous malformations (AVM).

IPC Classes  ?

• A61M 25/00 - CathetersHollow probes
• A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord