An improved protocol for the synthesis of oligonucleotides is provided. A liquid composition for the cleavage of a di(p-methoxyphenyl)phenylmethyl protecting group from a hydroxyl group and the use thereof in chemical synthesis of oligonucleotides is disclosed.
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
The invention relates to a drying bag for drying a biological or pharmaceutical material, which comprises a bag shell, a bag interior cavity and a bag shell access opening, a double fixation tensioning belt and a closable bag access opening, wherein the bag shell is partly made of a pliable first plastic foil and partly made of a vapor permeable sheet, and the double fixation tensioning belt is detachably connected at a supporting tub, when the drying bag is positioned for drying in the supporting tub. Furthermore, a drying system comprising the drying bag positioned in the supporting tub is disclosed. Additionally, a method for drying of a material to be dried using the drying system is disclosed.
F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
The invention relates to a drying bag for drying a biological or pharmaceutical material, which comprises a bag shell, a bag interior cavity and a bag shell access opening, a plate connected to the bag shell and a closable bag access opening, wherein the bag shell is partly made of a pliable first plastic foil and partly made of a vapor permeable sheet, and the plate is detachably connected at a supporting tub, when the drying bag is positioned for drying in the supporting tub. Furthermore, a drying system comprising the drying bag positioned in the supporting tub is disclosed. Additionally, a method for drying of a material to be dried using the drying system is disclosed.
F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)#to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.
C07H 19/067 - Pyrimidine radicals with ribosyl as the saccharide radical
C07H 19/167 - Purine radicals with ribosyl as the saccharide radical
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
5.
LYSINE SALT AND METHOD OF MANUFACTURING A LYSINE DERIVATIVE
The invention relates to a Bsmoc-protected lysine salt of formula (1X), e.g., a hydrochloric acid salt (n = 1, HY = hydrochloric acid). It further relates to a method of manufacturing Bsmoc-protected lysine derivatives, which employs the Bsmoc-protected lysine salt of formula (1X) and comprises the step of reacting the epsilon amino group of lysine with an 10 activated carboxylic acid derivative. Some of the obtainable Bsmoc-protected lysine derivatives with their side chain modification are useful as starting materials in solid phase peptide synthesis.
C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
C07C 251/02 - Compounds containing nitrogen atoms doubly- bound to a carbon skeleton containing imino groups
C07D 333/50 - Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
6.
METHOD AND COMPOSITION FOR OLIGONUCLEOTIDE SYNTHESIS
The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.
C07H 19/067 - Pyrimidine radicals with ribosyl as the saccharide radical
C07H 19/167 - Purine radicals with ribosyl as the saccharide radical
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
7.
METHOD OF MANUFACTURING A PEPTIDE WITH A LYSINE DERIVATIVE
The invention relates to a method of manufacturing a peptide P, which comprises a step of condensing of an alpha amino acid derivative S-am, which has one unprotected alpha amino group or one unprotected alpha imino group, with a protected alpha amino acid derivative of formula (Pr-L), wherein the amino protecting group RL-N-1 is 1,1-dioxobenzo[b]thiophen-2-ylmethyloxycarbonyl (Bsmoc). The invention relates also to a method of manufacturing the alpha amino acid derivative of formula (Pr-L) and an involved lysine derivative with its alpha amino group being protected by 1,1-dioxobenzo[b]thiophen-2-ylmethyloxycarbonyl (Bsmoc).
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
C07C 221/00 - Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
The invention relates to a method for manufacturing a precipitated mixture, which contains liraglutide or a salt thereof (component (A)), comprising the steps of removing solid parts, mixing with an antisolvent, stirring precipitation suspension until an analytical HPLC sample results in a HPLC-UV chromatogram with a pre- defined area percentage of liraglutide (A) to N-terminally trifluoroacetylated liraglutide (B), and isolating the precipitation to obtain the precipitated mixture. Further, the present invention relates to a precipitated mixture, a method for manufacturing a purified liraglutide composition, and uses thereof. Furthermore, the invention relates to a method of analyzing the content of component (B).
A method for the solid-phase synthesis of a target oligonucleotide OTis disclosed, wherein said method comprises a step of incubating a nucleoside or oligonucleotide, which is covalently linked to a solid support and comprises a backbone hydroxyl moiety protected by a di(p-methoxyphenyl)phenylmethyl (DMT) protecting group, with a deprotection mixture, thereby cleaving said protecting group from said nucleoside or oligonucleotide, wherein said deprotection mixture is a liquid composition comprising a solvent, a protic acid having a pKa equal to or smaller than 4, and at least one alcohol of Formula (D), wherein in RD-1R,D-2R,D-3RD-4and RD-51616666-alkyl), F, Cl, Br, I, and CN. Such a method does not only suppress depurination, but also results in an acceptable product yield.
C07H 1/00 - Processes for the preparation of sugar derivatives
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
The invention pertains to a method for the synthesis of a peptide by condensing a first component and a second component, both independently selected from the group consisting of an amino acid and a peptide in the presence of a carbodiimide coupling agent, a first additive, and a second additive. The first additive is an optionally substituted 2-hydroxypyridine N-oxide. The second additive has a defined chemical structure and is used in a total molar amount of at least 1.0 to 5.0 equivalents relative to the first component. Further aspects of the invention relate to compositions comprising the aforementioned compounds.
A novel pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates are provided. The pseudo solid phase protecting group is represented by formula II wherein: * indicates the point of attachment to an oxygen atom of a hydroxyl moiety of the nucleoside, the nucleotide, the oligonucleotide, or of the conjugate of a nucleoside, a nucleotide or an oligonucleotide to be protected; c is 0 or 1; a is an integer of 1 to 12; R3 is H; R5 is O-R6 or H, where R6 is a C8-C40 aliphatic hydrocarbon group; each of R4 is independently O-R6, where R6 is at each occurrence independently a C8-C40 aliphatic hydrocarbon group; b is 1 to 3; with the proviso that if b is 1, at least one of R3 and R5 is not H; and with the further proviso that the sum of all carbon atoms contained in the R3, R4, and R5 moieties present is larger than 23 and smaller than 200.
C07H 19/073 - Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
C07H 19/173 - Purine radicals with 2-deoxyribosyl as the saccharide radical
C07H 23/00 - Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
An improved protocol for the synthesis of oligonucleotides is provided, which reduces the level of depurination. A liquid composition for the cleavage of a di(p-methoxyphenyl) phenylmethyl protecting group from a hydroxyl group and the use thereof in chemical synthesis of oligonucleotides is disclosed.
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
An improved protocol for the synthesis of oligonucleotides is provided, which reduces the level of depurination. A liquid composition for the cleavage of a di(p-methoxyphenyl) phenylmethyl protecting group from a hydroxyl group and the use thereof in chemical synthesis of oligonucleotides is disclosed.
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
A method and apparatus for the manufacture of disulfide bonded peptides is provided, wherein a solution of an oxidizing agent and a solution of a peptide comprising at least two sulfhydryl groups are added simultaneously into a reaction vessel under such conditions that the average concentration of the oxidizing agent inside the reaction vessel is essentially zero during simultaneous addition.
The invention relates to containers for the drying, especially the freeze-drying, of material. In particular, the invention relates to a lid of a drying container, said lid enabling to close the container body of the drying container so as to avoid i) contamination of the material to be dried inside the container and ii) spills of airborne solid particles of said material from the container to the environment. The lid comprises a lower and an upper frame with a vapor permeable sheet positioned in between. The invention further provides methods for the drying, especially the freeze-drying, of material.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals for use in industry and science; chemical
preparations for scientific purposes; chemical preparations
for use in industry; industrial chemicals; reagents for
research purposes; reagents for scientific purposes;
reagents for chemical analyses; chemical preparations for
scientific purposes, other than for medical or veterinary
purposes; chemical reagents, other than for medical or
veterinary purposes; chemicals for industry; chemical
reagents for scientific purposes; peptides for use in
industry and science; proteins for use in industry and
science; oligonucleotides for use in industry and science;
small molecules for use in industry and science;
oligopeptides for industrial purposes; proteins for
industrial purposes; oligonucleotides for industrial
purposes; proteins for use in manufacture; oligonucleotides
for use in manufacture; amino acids for industrial
purposes; amino acids for scientific purposes; peptide
substrates for scientific purposes; chemical preparations
for use in the manufacture of cosmetics; peptides for use in
the manufacture of cosmetics; proteins for use in the
manufacture of cosmetics; oligonucleotides for use in the
manufacture of cosmetics; small molecules for use in the
manufacture of cosmetics; chemical preparations for use in
the manufacture of medicines; chemical preparations for use
in the manufacture of pharmaceuticals; peptides for use in
the manufacture of pharmaceuticals; proteins for use in the
manufacture of pharmaceuticals; oligonucleotides for use in
the manufacture of pharmaceuticals; small molecules for use
in the manufacture of pharmaceuticals; chemical reagents for
use in genetic research; chemicals for use in
biotechnological manufacturing processes; chemicals for use
in biotechnological product development; active chemical
ingredients for use in the manufacture of pharmaceuticals;
active chemical ingredients for use in the manufacture of
anti-cancer drugs; active chemical ingredients for use in
the manufacture of anti-diabetes drugs; active chemical
ingredients for use in the manufacture of drugs against
metabolic diseases; active chemical ingredients for use in
the manufacture of drugs for wound healing; active chemical
ingredients for use in the manufacture of drugs against
genetic diseases; active chemical ingredients for use in
the manufacture of drugs against neurologic diseases;
amides for use in manufacture; chemical additives for use in
manufacture; chemical additives for use in the manufacture
of cosmetics; chemical additives for use in the manufacture
of medicines; chemical additives for use in the manufacture
of pharmaceuticals; diagnostic preparations for scientific
or research purposes; diagnostic preparations, other than
for medical or veterinary purposes; diagnostic reagents for
scientific or research purposes; diagnostic reagents, other
than for medical or veterinary purposes; biological
preparations for use in industry and science; biological
preparations, other than for medical or veterinary purposes;
adjuvants, other than for medical or veterinary purposes;
biochemical catalysts; biochemical precursors for scientific
purposes; biochemical preparations for scientific purposes;
oligonucleotides for scientific purposes; proteins for
scientific purposes; peptides for scientific purposes;
biochemicals for in vitro and in vivo scientific purposes;
emollients for industrial purposes; emollients for use in
the manufacture of cosmetics; emollients for use in the
manufacture of pharmaceuticals; enzyme stabilizers; enzyme
substrates; phosphoproteins. Chemical reagents for medical or veterinary purposes;
reagents for medical purposes; chemical preparations for
medical purposes; peptides for medical purposes; proteins
for medical purposes; oligonucleotides for medical purposes;
small molecules for medical purposes; amino acids for
medical purposes; chemical preparations for pharmaceutical
purposes; peptides for pharmaceutical purposes; synthetic
peptides for pharmaceutical purposes; proteins for
pharmaceutical purposes; oligonucleotides for pharmaceutical
purposes; small molecules for pharmaceutical purposes;
chemical preparations for veterinary purposes; peptides for
veterinary purposes; proteins for veterinary purposes;
oligonucleotides for veterinary purposes; small molecules
for veterinary purposes; amino acids for veterinary
purposes; pharmaceutical preparations; pharmaceutical
preparations containing amino acids; pharmaceutical
substances; chemico-pharmaceutical preparations; diagnostic
preparations for medical purposes; diagnostic preparations
for veterinary purposes; pharmaceutical and biological
preparations for diagnostic purposes; diagnostic test
reagents for medical or veterinary purposes; peptides for
diagnostic purposes; proteins for diagnostic purposes;
oligonucleotides for diagnostic purposes; small molecules
for diagnostic purposes; diagnostic kits comprising
diagnostic agents, preparations and substances for medical
purposes; chemical preparations for the diagnosis of
pregnancy; biochemical preparations for medical or
veterinary purposes; biological and chemical reagents for
medical or veterinary purposes; biological preparations for
diagnostic purposes; biological preparations for medical
purposes; biological preparations for veterinary purposes;
preparations against metabolic diseases; preparations for
wound healing; preparations against genetic diseases;
preparations against neurologic diseases; biological
reagents for medical purposes; biological reagents for
veterinary purposes; adjuvants for medical purposes;
adjuvants for veterinary purposes; antibacterial
preparations; anti-cancer preparations; antitumor drugs;
biopharmaceuticals for the treatment of cancer;
biotechnological preparations for medical purposes;
anti-cancer preparations; anti-diabetic preparations;
pharmaceutical preparations used in chemotherapy; clinical
diagnostic reagents; cosmeceuticals for therapeutic or
medical purposes; dermatological preparations; diagnostic
biomarker reagents for medical purposes; dietary
supplements with a cosmetic effect; dietetic substances
adapted for medical purposes; dietetic substances adapted
for veterinary purposes; drug delivery agents; injectable
solutions for medical purposes; in vitro diagnostic
preparations for medical purposes; medical diagnostic
reagents and assays for testing of body fluids; nucleic acid
sequences for medical and veterinary purposes; reagents for
use in medical genetic testing; reagents for use in
veterinary genetic testing. Custom manufacturing; custom manufacture of
pharmaceuticals; custom manufacture of biopharmaceuticals;
custom manufacturing of peptides; custom manufacturing of
proteins; custom manufacturing of oligonucleotides; custom
manufacturing of small molecules; processing of materials;
processing of chemicals; processing of chemical reagents;
processing of peptides; processing of proteins; processing
of oligonucleotides; processing of small molecules;
processing of medicinal materials; processing of
biopharmaceutical materials for others; refining services;
treatment of materials; treatment of biopharmaceutical
materials; treatment of materials upon request for third
parties; treatment of materials for third parties. Scientific research; chemical research; chemistry
services; chemical engineering; product research and
development; research and development of new products for
others; industrial research, development and testing;
research and development services in the field of chemistry;
research and development in the field of peptides; research
and development in the field of proteins; research and
development in the field of oligonucleotides; research and
development in the field of small molecules; research and
development services for the pharmaceutical industry;
research and development services in the field of
pharmaceutical preparations; research and development
services in the field of biochemistry; research and
development services in the field of cosmetics; research and
development services in the field of diagnostic
preparations; research and development services in the
field of gene expression systems; research in the fields of
chemistry and biology; development of methods of
manufacture; development of analytic methods; scientific
laboratory services; chemical and biological laboratory
services; scientific and industrial analysis and research
services; laboratory research and analysis; chemical
analysis; industrial analysis; analytical laboratory
services; chemical, biochemical, biological and
bacteriological research and analysis; analysis in the field
of molecular biology; computer-aided scientific research,
testing and analysis services; conducting of scientific
studies; preparation of reports relating to scientific
research; providing information about industrial analysis
and research services; Quality control; product testing;
evaluation of chemical analyses; evaluation of chemical
syntheses; evaluation of product development; advisory
services relating to material testing; consultancy in the
field of biochemistry; consultancy in the field of
chemistry; consultancy in the field of scientific and
industrial research; consultancy relating to laboratory
testing; consulting services in the field of recombinant DNA
technology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals intended for industry and science; chemical
preparations for scientific use; chemical preparations for
use in industry; industrial chemicals; reagents for
research purposes; reagents for scientific use; reagents
for chemical analyses; chemical preparations for scientific
use, other than for medical or veterinary use; chemical
reagents, other than for medical or veterinary use;
industrial chemicals; chemical reagents for scientific use;
peptides for use in industry and science; proteins for use
in industry and science; oligonucleotides for use in
industry and science; small molecules for use in industry
and science; oligopeptides for industrial use; proteins for
industrial use; oligonucleotides for industrial use;
proteins for use in manufacture; oligonucleotides for use
in manufacture; amino acids for industrial purposes; amino
acids for scientific use; peptide substrates for scientific
use; chemical preparations for use in the manufacture of
cosmetics; peptides for use in the manufacture of
cosmetics; proteins for use in the manufacture of
cosmetics; oligonucleotides for use in the manufacture of
cosmetics; small molecules for use in manufacture of
cosmetics; chemical preparations for use in the manufacture
of medicines; chemical preparations for use in the
manufacture of pharmaceuticals; peptides for use in the
manufacture of pharmaceuticals; proteins for use in the
manufacture of pharmaceuticals; oligonucleotides for use in
the manufacture of pharmaceuticals; small molecules for use
in manufacture of pharmaceutical products; chemical reagents
for genetic research; chemical products for use in
biotechnological manufacturing processes; chemical products
used in the development of biotechnological products; active
chemical ingredients for use in the manufacture of
pharmaceuticals; active chemical ingredients for use in the
manufacture of anti-cancer medicines; active chemical
ingredients for use in the manufacture of medicines against
diabetes; active chemical ingredients for use in the
manufacture of medicines against metabolic diseases; active
chemical ingredients for use in the manufacture of medicines
for wound healing; active chemical ingredients for use in
the manufacture of medicines against genetic diseases;
active chemical ingredients for use in the manufacture of
medicines against neurological diseases; amides for use in
manufacture; chemical additives for use in manufacture;
chemical additives for use in manufacture of cosmetics;
chemical additives for use in the manufacture of medicines;
chemical additives for use in the manufacture of
pharmaceuticals; diagnostic preparations for scientific or
research use; diagnostic preparations, other than for
medical or veterinary use; diagnostic reagents for
scientific or research use; diagnostic reagents, other than
for medical or veterinary use; biological preparations for
use in industry and science; biological preparations, other
than for medical or veterinary use; additives, other than
for medical or veterinary use; biochemical catalysts;
biochemical precursors for scientific use; biochemical
preparations for scientific use; oligonucleotides for
scientific use; proteins for scientific use; peptides for
scientific use; biochemical products for in-vitro and
in-vivo scientific use; emollients for industrial use;
emollients for use in the manufacture of cosmetics;
emollients for use in the manufacture of pharmaceutical
products; enzyme stabilizers; enzymatic substrates;
phosphoproteins. Chemical reagents for medical or veterinary use; reagents
for medical use; chemical preparations for medical use;
peptides for medical use; proteins for medical use;
oligonucleotides for medical use; small molecules for
medical use; amino acids for medical use; chemical
preparations for pharmaceutical use; peptides for
pharmaceutical use; synthetic peptides for pharmaceutical
use; proteins for pharmaceutical use; oligonucleotides for
pharmaceutical use; small molecules for pharmaceutical use;
chemical preparations for veterinary use; peptides for
veterinary use; proteins for veterinary use;
oligonucleotides for veterinary use; small molecules for
veterinary use; amino acids for veterinary use;
pharmaceutical preparations; pharmaceutical preparations
containing amino acids; pharmaceutical substances;
chemical-pharmaceutical preparations; diagnostic
preparations for medical purposes; diagnostic preparations
for veterinary use; biological and pharmaceutical
preparations for diagnostic purposes; diagnostic test
reagents for medical or veterinary use; peptides for
diagnostic purposes; proteins for diagnostic purposes;
oligonucleotides for diagnostic purposes; small molecules
for diagnostic purposes; diagnostic kits containing
diagnostic agents, preparations and substances for medical
use; chemical preparations for the diagnosis of pregnancy;
biochemical preparations for medical or veterinary use;
biological and chemical reagents for medical or veterinary
use; biological preparations for diagnostic purposes;
biological preparations for medical use; biological
preparations for veterinary use; preparations against
metabolic diseases; preparations for wound healing;
preparations against genetic diseases; preparations against
neurological diseases; biological reagents for medical use;
biological reagents for veterinary use; adjuvants for
medical use; adjuvants for veterinary use; antibacterial
preparations; anti-cancer preparations; anti-tumor
medicines; biopharmaceutical products for cancer treatment;
biotechnological preparations for medical use; anti-cancer
preparations; anti-diabetic preparations; pharmaceutical
preparations for use in chemotherapy; clinical diagnostic
reagents; cosmeceuticals for therapeutic or medical use;
dermatological preparations; diagnostic biomarker reagents
for medical use; food supplements with cosmetic effect;
dietetic substances adapted for medical use; dietetic
substances adapted for veterinary use; drug delivery
agents; injectable solutions for medical use; in-vitro
diagnostic preparations for medical use; medical diagnostic
reagents and assays for testing of body fluids; nucleic acid
sequences for medical and veterinary use; reagents for use
in medical genetic testing; reagents for use in veterinary
genetic testing. Custom manufacturing; custom manufacture of pharmaceutical
products; custom manufacture of biopharmaceutical products;
custom manufacture of peptides; custom manufacture of
proteins; custom manufacture of oligonucleotides; custom
manufacture of small molecules; treatment of materials;
treatment of chemical products; treatment of chemical
reagents; treatment of peptides; treatment of proteins;
treatment of oligonucleotides; treatment of small molecules;
treatment of medicinal materials; treatment of
biopharmaceutical materials for third parties; refining
services; treatment of materials; treatment of
biopharmaceutical materials; treatment of materials on
request for third parties; treatment of materials for third
parties. Scientific research; chemical research; chemistry
services; chemical engineer; research and development of
products; research and development of new products for
third parties; industrial research, development and
testing; research and development services in the field of
chemistry; research and development in the field of
peptides; research and development in the field of
proteins; research and development in the field of
oligonucleotides; research and development in the field of
small molecules; research and development services for the
pharmaceutical industry; research and development services
in the field of pharmaceutical preparations; research and
development services in the field of biochemistry; research
and development services in the field of cosmetics; research
and development services in the field of diagnostic
preparations; research and development services in the
field of gene expression systems; research in the fields of
chemistry and biology; development of manufacturing
processes; development of analytical methods; scientific
laboratory services; chemical and biological laboratory
services; scientific and industrial analysis and research
services; laboratory research and analysis; chemical
analysis; industrial analysis; laboratory analysis services;
chemical, biochemical, biological and bacteriological
research and analysis; analysis in the field of molecular
biology; computer-assisted scientific research, testing and
analysis services; conducting of scientific studies;
preparation of reports concerning scientific research;
provision of information on industrial analysis and research
services; quality control; product testing; evaluation of
chemical analyses; evaluation of chemical syntheses;
evaluation of product development; consulting services
relating to testing of materials; consultation in the field
of biochemistry; consultation in the field of chemistry;
consulting in the field of scientific and industrial
research; consultation relating to laboratory testing;
consulting services in the field of recombinant DNA
technology.
The present invention refers to a method of purifying a glucagon peptide, the method comprising a two dimensional reversed phase high performance liquid chromatography protocol, wherein the first step is carried out at using a mobile phase comprising a triethylammonium phosphate (TEAP) buffer and acetonitrile, and the second step is carried out at using a mobile phase comprising aqueous acetic acid and acetonitrile.
The present invention relates to methods and compounds for the solid phase synthesis of peptides carrying a substituent at an amino group of an amino acid side chain.
A method and apparatus for the manufacture of disulfide bonded peptides is provided, wherein a solution of an oxidizing agent and a solution of a peptide comprising at least two sulfhydryl groups are added simultaneously into a reaction vessel under such conditions that the average concentration of the oxidizing agent inside the reaction vessel is essentially zero during simultaneous addition.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals for use in industry and science; chemical
preparations for scientific use; chemical preparations for
use in industry; industrial chemicals; reagents for
research purposes; reagents for scientific use; reagents
for chemical analyses; chemical preparations for scientific
use, other than for medical or veterinary use; chemical
reagents, other than for medical or veterinary use;
chemicals for industry; chemical reagents for scientific
use; peptides for use in industry and science; proteins for
use in industry and science; oligonucleotides for use in
industry and science; small molecules for use in industry
and science; oligopeptides for industrial use; proteins for
industrial use; proteins for use in manufacture; amino
acids for industrial use; amino acids for scientific use;
peptide substrates for scientific use; chemical preparations
for use in the manufacture of cosmetics; peptides for use
in the manufacture of cosmetics; proteins for use in the
manufacture of cosmetics; oligonucleotides for use in the
manufacture of cosmetics; small molecules for use in the
manufacture of cosmetics; chemical preparations for use in
the production of medicines; chemical preparations for use
in the manufacture of pharmaceuticals; peptides for use in
the manufacture of pharmaceuticals; proteins for use in the
manufacture of pharmaceuticals; oligonucleotides for use in
the manufacture of pharmaceuticals; small molecules for use
in the manufacture of pharmaceuticals; chemical reagents for
use in genetic research; chemicals for use in
biotechnological manufacturing processes; chemicals for use
in biotechnological product development; active chemical
ingredients for use in the manufacture of pharmaceuticals;
active chemical ingredients for use in the manufacture of
anti-cancer drugs; active chemical ingredients for use in
the manufacture of anti-diabetes drugs; active chemical
ingredients for use in the manufacture of drugs against
metabolic diseases; active chemical ingredients for use in
the manufacture of drugs for wound healing; active chemical
ingredients for use in the manufacture of drugs against
genetic diseases; active chemical ingredients for use in
the manufacture of drugs against neurological diseases;
amides for use in manufacture; chemical additives for use in
manufacture; chemical additives for use in the manufacture
of cosmetics; chemical additives for use in the manufacture
of medicines; chemical additives for use in the manufacture
of pharmaceuticals; diagnostic preparations for scientific
or research use; diagnostic preparations, other than for
medical or veterinary use; diagnostic reagents for
scientific or research use; diagnostic reagents, other than
for medical or veterinary use; biological preparations for
use in industry and science; biological preparations, other
than for medical or veterinary use; adjuvants, other than
for medical or veterinary purposes; biochemical catalysts;
biochemical precursors for scientific use; biochemical
preparations for scientific use; biochemicals for in vitro
and in vivo scientific use; emollients for industrial use;
emollients for use in the manufacture of cosmetics;
emollients for use in the manufacture of pharmaceuticals;
enzyme stabilizers; enzyme substrates; phosphoproteins. Chemical reagents for medical or veterinary use; reagents
for medical use; chemical preparations for medical use;
peptides for medical use; proteins for medical use;
oligonucleotides for medical use; small molecules for
medical use; amino acids for medical use; chemical
preparations for pharmaceutical use; peptides for
pharmaceutical use; synthetic peptides for pharmaceutical
use; proteins for pharmaceutical use; oligonucleotides for
pharmaceutical use; small molecules for pharmaceutical use;
chemical preparations for veterinary use; peptides for
veterinary use; proteins for veterinary use;
oligonucleotides for veterinary use; small molecules for
veterinary use; amino acids for veterinary use;
pharmaceutical preparations; pharmaceutical preparations
containing amino acids; pharmaceutical substances;
chemico-pharmaceutical preparations; diagnostic preparations
for medical use; diagnostic preparations for veterinary
use; pharmaceutical and biological preparations for
diagnostic purposes; diagnostic test reagents for medical or
veterinary use; peptides for diagnostic purposes; proteins
for diagnostic purposes; oligonucleotides for diagnostic
purposes; small molecules for diagnostic purposes;
diagnostic kits comprising diagnostic agents, preparations
and substances for medical use; chemical preparations for
the diagnosis of pregnancy; biochemical preparations for
medical or veterinary use; biological and chemical reagents
for medical or veterinary use; biological preparations for
diagnostic purposes; biological preparations for medical
use; biological preparations for veterinary use;
preparations against metabolic diseases; preparations for
wound healing; preparations against genetic diseases;
preparations against neurologic diseases; biological
reagents for medical use; biological reagents for
veterinary use; adjuvants for medical use; adjuvants for
veterinary use; antibacterial preparations; anti-cancer
preparations; antitumor drugs; biopharmaceuticals for the
treatment of cancer; biotechnological preparations for
medical use; anti-cancer preparations; anti-diabetic
preparations; chemotherapeutics; clinical diagnostic
reagents; cosmeceuticals for therapeutic or medical use;
dermatological preparations; diagnostic biomarker reagents
for medical use; dietary supplements with a cosmetic
effect; dietetic substances adapted for medical use;
dietetic substances adapted for veterinary use; drug
delivery agents; injectable solutions for medical use; in
vitro diagnostic preparations for medical use; medical
diagnostic reagents and assays for testing of body fluids;
nucleic acid sequences for medical and veterinary use;
reagents for use in medical genetic testing; reagents for
use in veterinary genetic testing. Custom manufacturing; custom manufacture of
pharmaceuticals; custom manufacture of biopharmaceuticals;
custom manufacturing of peptides; custom manufacturing of
proteins; custom manufacturing of oligonucleotides; custom
manufacturing of small molecules; processing of materials;
processing of chemicals; processing of chemical reagents;
processing of peptides; processing of proteins; processing
of oligonucleotides; processing of small molecules;
processing of medicinal materials; processing of
biopharmaceutical materials for others; refining services;
treatment of materials; treatment of biopharmaceutical
materials; treatment of materials upon request for third
parties; treatment of materials for third parties. Scientific research; chemical research; chemistry
services; chemical engineering; product research and
development; research and development of new products for
others; industrial research, development and testing;
research and development services in the field of chemistry;
research and development in the field of peptides; research
and development in the field of proteins; research and
development in the field of oligonucleotides; research and
development in the field of small molecules; research and
development services for the pharmaceutical industry;
research and development services in the field of
pharmaceutical preparations; research and development
services in the field of biochemistry; research and
development services in the field of cosmetics; research and
development services in the field of diagnostic
preparations; research and development services in the
field of gene expression systems; research in the fields of
chemistry and biology; development of methods of
manufacture; development of analytic methods; scientific
laboratory services; chemical and biological laboratory
services; scientific and industrial analysis and research
services; laboratory research and analysis; chemical
analysis; industrial analysis; analytical laboratory
services; chemical, biochemical, biological and
bacteriological research and analysis; analysis in the field
of molecular biology; computer-aided scientific research,
testing and analysis services; conducting of scientific
studies; preparation of reports relating to scientific
research; providing information about industrial analysis
and research services; quality control; product testing;
evaluation of chemical analyses; evaluation of chemical
syntheses; evaluation of product development; advisory
services relating to material testing; consultancy in the
field of biochemistry; consultancy in the field of
chemistry; consultancy in the field of scientific and
industrial research; consultancy relating to laboratory
testing; consulting services in the field of recombinant DNA
technology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals for use in industry and science; chemical preparations for scientific use; chemical preparations for use in industry; industrial chemicals; reagents for research purposes; reagents for scientific use; chemical preparations for scientific use, other than for medical or veterinary use; chemical reagents, other than for medical or veterinary use; chemicals for industry; chemical reagents for scientific use; peptides for use in industry and science; proteins for use in industry and science; oligonucleotides for use in industry and science; oligopeptides for industrial use; proteins for industrial use; proteins for use in manufacture; amino acids for industrial use; amino acids for scientific use; peptide substrates for scientific use; chemical preparations for use in the manufacture of cosmetics; peptides for use in the manufacture of cosmetics; proteins for use in the manufacture of cosmetics; oligonucleotides for use in the manufacture of cosmetics; chemical preparations for use in the production of medicines; chemical preparations for use in the manufacture of pharmaceuticals; peptides for use in the manufacture of pharmaceuticals; proteins for use in the manufacture of pharmaceuticals; oligonucleotides for use in the manufacture of pharmaceuticals; chemical reagents for use in genetic research; chemicals for use in biotechnological manufacturing processes; chemicals for use in biotechnological product development; active chemical ingredients for use in the manufacture of anti-cancer drugs; active chemical ingredients for use in the manufacture of anti-diabetes drugs; active chemical ingredients for use in the manufacture of drugs against metabolic diseases; active chemical ingredients for use in the manufacture of drugs for wound healing; active chemical ingredients for use in the manufacture of drugs against genetic diseases; active chemical ingredients for use in the manufacture of drugs against neurological diseases; amides for use in manufacture; chemical additives for use in the manufacture of cosmetics; chemical additives for use in the manufacture of medicines; chemical additives for use in the manufacture of pharmaceuticals; diagnostic preparations for scientific or research use; diagnostic preparations, other than for medical or veterinary use; diagnostic reagents for scientific or research use; diagnostic reagents, other than for medical or veterinary use; biological preparations for use in industry and science; biological preparations, other than for medical or veterinary use; adjuvants, other than for medical or veterinary purposes; biochemical catalysts; biochemical preparations for scientific use; biochemicals for in vitro and in vivo scientific use; emollients for industrial use; emollients for use in the manufacture of cosmetics; emollients for use in the manufacture of pharmaceuticals; enzyme stabilizers; enzyme substrates; phosphoproteins Chemical reagents for medical or veterinary use; reagents for medical use; peptides for medical use; protein arrays for medical diagnostic use; oligonucleotides for medical use; amino acids for medical use; peptides for pharmaceutical use; synthetic peptides for pharmaceutical use; peptides for veterinary use; amino acids for veterinary use; diagnostic preparations for medical use; diagnostic preparations for veterinary use; biological and pharmaceutical preparations for diagnostic purposes; diagnostic test reagents for medical or veterinary use; peptides for diagnostic purposes; proteins for diagnostic purposes; oligonucleotides for diagnostic purposes; diagnostic kits containing diagnostic agents, preparations and substances for medical use; chemical preparations for the diagnosis of pregnancy; biological and chemical reagents for medical or veterinary use; biological preparations for diagnostic purposes; pharmaceutical preparations against metabolic diseases; pharmaceutical preparations for wound healing; pharmaceutical preparations against genetic diseases; pharmaceutical preparations against neurological diseases; biological reagents for medical use; biological reagents for veterinary use; adjuvants for medical use; adjuvants for veterinary use; anti-bacterial preparations for medical purposes; anti-cancer preparations; antitumor drugs; biopharmaceutical anti-tumor medicines; biopharmaceuticals for the treatment of cancer; anti-diabetic preparations; chemotherapeutics; cosmeceuticals for therapeutic or medical use, namely, medicated soap; dermatological preparations; diagnostic biomarker reagents for medical use; food supplements with cosmetic effect; dietetic preparations adapted for medical use; dietetic preparations adapted for veterinary use; drug delivery agents in the form of coatings for tablets that facilitate the delivery of pharmaceutical preparations; in vitro diagnostic preparations for medical use; medical diagnostic reagents and assays for testing of body fluids; nucleic acid sequences for medical and veterinary use; reagents for use in medical genetic testing; reagents for use in veterinary genetic testing Custom manufacture of pharmaceuticals; custom manufacture of biopharmaceuticals; custom manufacturing of peptides; custom manufacturing of proteins; custom manufacturing of oligonucleotides; processing of chemicals; processing of chemical reagents; processing of peptides; processing of proteins; processing of oligonucleotides; processing of medicinal materials; processing of biopharmaceutical materials for others; treatment of biopharmaceutical materials Scientific research; chemical research; chemical engineering; product research and development; research and development of new products for others; research and development services in the field of chemistry; research and development in the field of peptides; research and development in the field of proteins; research and development in the field of oligonucleotides; research and development services for the pharmaceutical industry; research and development services in the field of pharmaceutical preparations; research and development services in the field of biochemistry; research and development services in the field of cosmetics; research and development services in the field of diagnostic preparations; research and development services in the field of gene expression systems; research in the fields of chemistry and biology; development of methods of manufacture for peptides, proteins, oligonucleotides, pharmaceuticals, and cosmetics; development of analytic methods for developing for peptides, proteins, oligonucleotides, pharmaceuticals, and cosmetics; scientific laboratory services; chemical analysis; chemical, biochemical, biological and bacteriological research and analysis; analysis in the form of research in the field of molecular biology; conducting of scientific feasibility studies; providing information in the form of preparation of reports relating to scientific research; quality control; product testing; advisory services relating to material testing; consultancy in the field of biochemistry research; consultancy in the field of chemistry research; consultancy in the field of scientific and industrial research; consultancy relating to laboratory testing research; consulting services in the field of recombinant DNA technology research
The present invention refers to a method of purifying a glucagon peptide, the method comprising a two dimensional reversed phase high performance liquid chromatography protocol, wherein the first step is carried out at using a mobile phase comprising a triethylammonium phosphate (TEAP) buffer and acetonitrile, and the second step is carried out at using a mobile phase comprising aqueous acetic acid and acetonitrile.
The present invention relates to methods and compounds for the solid phase synthesis of peptides carrying a substituent at an amino group of an amino acid side chain.
The present invention refers to a method of purifying a glucagon-like peptide 1 analogs, the method comprising a two dimensional reversed phase high performance liquid chromatography protocol, wherein the first step is carried out at a pH value between 7.0 to 7.8 using a mobile phase comprising a phosphate buffer and acetonitrile, and the second step is carried out at a pH value below 3.0 using a mobile phase comprising trifluoroacetic acid and acetonitrile.
B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
C07K 2/00 - Peptides of undefined number of amino acidsDerivatives thereof
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
B01D 15/34 - Size-selective separation, e.g. size-exclusion chromatographyGel filtrationPermeation
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
The present invention refers to a method for preparing a glucagon-like peptide, comprising precipitation of the peptide or of a precursor peptide by means of mixing with an anti-solvent comprising diisopropyl ether and acetonitrile. Further, the present invention also relates to a peptide conjugated to a solid phase and a pharmaceutical composition comprising a Liraglutide peptide obtainable from a method according to the present invention.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Chemicals for use in industry and science, namely, amino acids, peptides, reagents for peptide synthesis, amino acid derivatives, cytokines, enzyme inhibitors, enzyme substrates, growth factors, peptide substrates, all for use as scientific and laboratory research reagents in the field of medicine and molecular biology; synthetic peptides and peptide derivatives for the use as a pharmaceutical intermediate; synthetic oligonucleotides and oligonucleotide derivatives for the use as a pharmaceutical intermediate
(2) Chemical specialities for compounds and reagents purposes in the field of peptide and oligonucleotide synthesis
(3) Peptides for use in research and the manufacture of reagents, diagnostic reagents for medical-science research use
(4) Chemical products for the fresh-keeping and preserving of foods; food preserving chemicals; chemical compositions for preserving foodstuffs; chemical preparations for preserving foodstuffs; biochemical used in the pharmaceutical industry as tools for pharmacological and physiological research of peptides and bioactive compounds in animals and humans, namely, biochemicals in the form of monoclonal antibodies for in vitro scientific use, biochemicals in the form of monoclonal antibodies for research use, polypeptide biochemicals for in vitro research use, agricultural biochemicals
(5) Synthetic peptides, synthetic peptide derivatives, synthetic oligonucleotides, and synthetic oligonucleotide derivatives for veterinary purposes, namely, for veterinary research use; biochemical in the form of synthetic peptides, synthetic peptide derivatives, synthetic oligonucleotides, and synthetic oligonucleotide derivatives for veterinary research use; biochemicals in the form of synthetic peptides, synthetic peptide derivatives, synthetic oligonucleotides, and synthetic oligonucleotide derivatives for in vitro scientific use; biochemicals in the form of synthetic peptides, synthetic peptide derivatives, synthetic oligonucleotides, and synthetic oligonucleotide derivatives for biological, chemical, medical-scientific and veterinary research use
(6) Pharmaceutical and veterinary products, namely, pharmaceutical preparations for use in the treatment of bleeding, premature labor, pulmonary hypertension, erectile disfunction, coronary syndromes, prostate cancer, endometriosis, central precocious puberty, uterine myoma, osteoporosis, hypercalcernia, Paget's disease, reflex sympathetic dystrophy, nocturnal enureses, central diabetes insipidus, polyuria, polydipsia, hemophilia A, von Willebrand disease, unstable angina, myocardial infarction, hypoglycemia, ovarian follicular cysts, cryptochism, breast cancer, growth hormone deficiency, acromegaly, carcinoid syndrome, thyrotrophic adenomas, diabetes II, VIPosmas, ulcer bleeding, hemorrhagic gastritis, postoperative pancreatic and duodenal fistulae, variceal hemorrhage, neurological diseases, namely, Alzheimer's, Huntington's disease, cerebral palsy, acute spinal cord injury, Amyotrophic Lateral Sclerosis (ALS), ataxia, bell's palsy, brain tumours, cerebral aneurysm, epilepsy and seizures, Guillain-Barré Syndrome, headache, head injury, hydrocephalus, lumbar disk disease (herniated disk), meningitis, multiple sclerosis, muscular dystrophy, neurocutaneous syndromes, Parkinson's disease, stroke, disautonomia, dementia, autism, Asperger syndrome, shingles, schizophrenia, rheumatic diseases, dermatological diseases, namely, acne, atopic dermatitis, melasma, vitiligo, psoriasis, uticaria, sunburn, dermatitis, eczema, rosacea, tinea pedis, skin cancers, skin pigmentation diseases, warts, diseases of the intestinal tract, cancer, conjunctivitis, glaucoma, ocular hypertension, transfusion-induced hemosiderosis, candidasis, dermatophytosis, pityriasis, congenital homocystinuria, hyperammonaemia, hepatic encephalopathy, ischemic heart disease, chorioretinal vascular disorders, hypertension, endema, insomnia, bipolar disorder, and schizophrenia; pharmaceutical preparations for use in the diagnosis of gastrinoma; veterinary preparations for use in the induction of ovulation in estrous mares, and reproduction control in dogs and cats; pharmaceutical preparations for use in the diagnosis of Cushing's syndrome, hypothalamic-pituitary-gonadal axis function, growth hormone deficiency, pancreatic exocrine dysfunction, gastrinoma, and adrenocortical insufficiency; dietetic food and substance for pharmaceutical or veterinary use, namely, synthetic peptides as tastemodulating food additives for medical use, appetite suppressors for medical use; food supplements for humans and animals consisting of amino acids; fungicides; herbicides
(7) Diagnostic preparations, namely, synthetic peptides, synthetic peptide derivatives, synthetic oligonucleotides, and synthetic oligonucleotide derivatives for medical purposes, diagnostic biochemical in the form of synthetic peptides, synthetic peptide derivatives, synthetic oligonucleotides, and synthetic oligonucleotide derivatives for medical laboratory use; synthetic peptides, synthetic peptide derivatives, synthetic oligonucleotides, and synthetic oligonucleotide derivatives for veterinary purposes, namely, for treating diseases in animals
The present invention refers to a method for preparing a glucagon-like peptide, comprising precipitation of the peptide or of a precursor peptide by means of mixing with an anti-solvent comprising diisopropyl ether and acetonitrile. Further, the present invention also relates to a peptide conjugated to a solid phase and a pharmaceutical composition comprising a Liraglutide peptide obtainable from a method according to the present invention.
The present invention refers to a method of purifying a glucagon-like peptide 1 analogs, the method comprising a two dimensional reversed phase high performance liquid chromatography protocol, wherein the first step is carried out at a pH value between 7.0 to 7.8 using a mobile phase comprising a phosphate buffer and acetonitrile, and the second step is carried out at a pH value below 3.0 using a mobile phase comprising trifluoroacetic acid and acetonitrile.
The present invention refers to a method of purifying a glucagon-like peptide 1 analogs, the method comprising a two dimensional reversed phase high performance liquid chromatography protocol, wherein the first step is carried out at a pH value between 7.0 to 7.8 using a mobile phase comprising a phosphate buffer and acetonitrile, and the second step is carried out at a pH value below 3.0 using a mobile phase comprising trifluoroacetic acid and acetonitrile.
The present invention refers to a method for preparing a glucagon-like peptide, comprising precipitation of the peptide or of a precursor peptide by means of mixing with an anti-solvent comprising diisopropyl ether and acetonitrile. Further, the present invention also relates to a peptide conjugated to a solid phase and a pharmaceutical composition comprising a Liraglutide peptide obtainable from a method according to the present invention.
The invention relates to containers for the drying, especially the freeze-drying,of material. In particular, the invention relates to a lid of a drying container, said lid enabling to close the container body of the drying container so as to avoid i) contamination of the material to be dried inside the container and ii) spills of airborne solid particles of said material from the container to the environment.The lid comprises a lower and an upper frame with a vapor permeable sheetpositioned in between. The invention further provides methods for the drying, especially the freeze-drying, of material.
F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
B65D 51/24 - Closures not otherwise provided for combined with auxiliary devices for non-closing purposes
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical products for use in industry and science; chemical
products used for preserving foodstuffs. Pharmaceutical and veterinary products; sanitary products
for medical purposes; dietetic food and substances for
medical or veterinary use; food supplements for humans and
animals; fungicides, herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals for use in industry and science, namely, amino acids, peptides, reagents for peptide synthesis, amino acid derivatives, cytokines, enzyme inhibitors, enzyme substrates, growth factors, peptide substrates, all for use as scientific and laboratory research reagents in the field of medicine and molecular biology; pharmaceutical intermediates for use in the further manufacture of pharmaceuticals; chemical products used for preserving foodstuffs Pharmaceutical and veterinary products, namely, pharmaceutical preparations for use in the treatment of bleeding, premature labor, pulmonary hypertension, erectile disfunction, coronary syndromes, prostate cancer, endometriosis, central precocious puberty, uterine myoma, osteoporosis, hypercalcernia, Paget's disease, reflex sympathetic dystrophy, nocturnal enureses, central diabetes insipidus, polyuria, polydipsia, hemophilia A, von Willebrand disease, unstable angina, myocardial infarction, hypoglycemia, ovarian follicular cysts, cryptochism, breast cancer, growth hormone deficiency, acromegaly, carcinoid syndrome, thyrotrophic adenomas, diabetes II, VIPosmas, ulcer bleeding, hemorrhagic gastritis, postoperative pancreatic and duodenal fistulae, variceal hemorrhage, neurological diseases, rheumatic diseases, skin diseases, diseases of the intestinal tract, cancer, conjunctivitis, glaucoma, ocular hypertension, Parkinson's disease, transfusion-induced hemosiderosis, candidasis, dermatophytosis, pityriasis, congenital homocystinuria, hyperammonaemia, hepatic encephalopathy, ischemic heart disease, chorioretinal vascular disorders, hypertension, endema, insomnia, bipolar disorder, and schizophrenia; pharmaceutical preparations for use in the diagnosis of gastrinoma; veterinary preparations for use in the induction of ovulation in estrous mares, and reproduction control in dogs and cats; pharmaceutical preparations for use in the diagnosis of Cushing's syndrome, hypothalamic-pituitary-gonadal axis function, growth hormone deficiency, pancreatic exocrine dysfunction, gastrinoma, and adrenocortical insufficiency; dietetic food and substances for medical or veterinary use, namely, taste-modulating food additives in the nature of peptides for medical use, appetite suppressors for medical use; food supplements for humans and animals; fungicides; herbicides
01 - Chemical and biological materials for industrial, scientific and agricultural use
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
PEPTIDES FOR USE IN RESEARCH AND THE MANUFACTURE OF REAGENTS, DIAGNOSTIC REAGENTS FOR SCIENCE AND RESEARCH USE CHEMIST SERVICES, NAMELY, CUSTOM SYNTHESIS OF CHEMICALS FOR OTHERS
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Chemical specialities for pharmaceutical and scientific use, pharmaceuticals, chemical products, namely, peptides, enzyme substrates; chemicals for use in the manufacture of pharmaceuticals and pharmaceutical specialities.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
biochemicals used in the pharmaceutical industry as tools for pharmacological and physiological research of peptides and bioactive compounds in animals and humans
